JP5916993B2 - Amino acid elution inhibitor - Google Patents

Description

The present invention relates to an amino acid elution inhibitor, and in particular, by suppressing the elution of skin amino acids when washing the face, body and hair, the skin barrier function and moisturizing function can be maintained, and healthy skin can be maintained. The present invention relates to an amino acid elution inhibitor that can be maintained.

The skin's stratum corneum contains essential biological components such as lipids and natural moisturizing factors (NMF), and maintains the barrier function and moisturizing function. Therefore, these components are retained without being eluted during washing. This is very important. The amount of amino acid, the main component of NMF in the stratum corneum, is known to have a very high correlation with the moisture retention and flexibility of the skin, and plays an important role in maintaining moist and healthy skin and scalp. Is responsible.

A skin cleanser is a cosmetic for washing away skin dirt by dissolving, solubilizing or dispersing it, usually using an aqueous carrier as a medium. On the other hand, in order to maintain moist and healthy skin and scalp, there is also a demand for a function (selectivity for removal) that does not excessively wash away vital components other than dirt. However, since the original function is to wash away dirt, the removal selectivity function is not often achieved sufficiently. Accordingly, when aqueous cleaning with a skin cleanser is performed, many biologically essential components such as NMF and lipids are eluted, and a person with a naturally low barrier function may further lower the skin barrier function.

For example, a method for limiting the contact between the skin and the cleaning material by increasing the foaming property with a foaming net, adsorbing dirt on the foam, and the like, for example, as a removal selectivity function in aqueous cleaning (see, for example, Patent Documents) 1), and a method for improving moisture retention by incorporating a herbal medicine component having high moisture retention (see, for example, Patent Document 2) has been proposed. However, the use of foaming can prevent the cleaning material from remaining on the skin and prevent the residual cleaning material from inducing inflammation, but it is difficult to prevent leakage of essential biological components. In particular, people with reduced skin barrier function sometimes see inflammation induced by such leakage of essential biological components. In addition, there is a limit to the amount of the moisturizing component added to the skin remaining in the cleansing agent, and the moisturizing property of the skin may not be improved as expected.

N-acetylglucosamine is one type of natural amino sugar obtained by decomposing high molecular polysaccharide chitin contained in the shell of crustaceans such as crabs and shrimps. In addition, it exists universally in the living body as a structural unit of the sugar chain part of mucopolysaccharides, glycoproteins, and glycolipids. Usually, it is produced in vivo by metabolism using glucose as a starting material, which is safe for humans. One of the high biological components. And as a physiological function of N-acetylglucosamine, the symptom improvement of arthritis, the growth promotion effect of bifidobacteria, etc. are known, and it is known that there exists a moisturizing effect also in skin (for example, patent document 3). reference.). Further, N-acetylglucosamine is blended in the cosmetic composition used for the cosmetic-impregnated laminate (see, for example, Patent Document 4). However, it has not been known that N-acetylglucosamine itself has a skin amino acid elution inhibitory effect.

JP 2002-12538 A Japanese Patent Laid-Open No. 2001-19994 JP 2004-339139 A JP 2008-208031 A

The present invention has been made in view of the background art described above, and by suppressing the elution of skin amino acids when washing the face, body and hair, the skin barrier function and moisturizing function can be maintained, and healthy skin An object of the present invention is to provide an amino acid elution inhibitor capable of maintaining the above.

As a result of intensive studies in view of the above problems, the present inventor has found that N-acetylglucosamine suppresses elution of skin amino acids (NMF) even by using a cleaning material, and has completed the present invention.

That is, the present invention is an amino acid elution inhibitor that suppresses elution of skin amino acids in washing with a surfactant , and is an amino acid elution inhibitor that contains N-acetylglucosamine as an active ingredient.

According to the amino acid elution inhibitor of the present invention, by suppressing the elution of skin amino acids when washing the face, body and hair, the skin barrier function and moisturizing function can be maintained, and healthy skin can be maintained. . Furthermore, by incorporating an amino acid elution inhibitor containing N-acetylglucosamine as an active ingredient, the elution of amino acids during washing is reduced, and the skin feel during use and after use, and washing with good foaming and washing effects Can provide a fee.

It is a graph which shows the result of the amino acid elution amount of this invention. It is a graph which shows the result of the variation | change_quantity of the same TEWL.

The configuration of the present invention will be described below.
The N-acetylglucosamine used for this invention should just be normally used as a cosmetic raw material. For example, it can be obtained by hydrolyzing natural polysaccharide chitin derived from the shell of crustaceans such as crabs and shrimps using known methods such as acids and enzymes. The production method is not particularly limited. For example, this includes Marine Sweet F and Marine Sweet YSK manufactured by Yaizu Fisheries Chemical Co., Ltd.

The amino acid elution inhibitor of the present invention is particularly effective when blended in a cleaning material. In this case, as the surfactant blended in the detergent, the detergent anionic surfactant is most preferable, and any anionic surfactant used in normal skin and hair detergents may be used alone. Even if it mix | blends, 2 or more types of combinations may be sufficient. Moreover, 1 or more types chosen from the nonionic surfactant and amphoteric surfactant which are surfactants other than anionicity may be included.

Examples of the anionic surfactant include fatty acid soaps (for example, sodium laurate, sodium palmitate, etc.); higher alkyl sulfates (for example, sodium lauryl sulfate, potassium lauryl sulfate, etc.); alkyl ether sulfates (for example, POE) -Triethanolamine lauryl sulfate, POE-sodium lauryl sulfate, etc.); N-acyl sarcosine acid (eg, sodium lauroyl sarcosine, etc.); higher fatty acid amide sulfonates (eg, sodium N-myristoyl-N-methyl taurate, coconut oil) Fatty acid methyl taurine sodium, lauryl methyl taurine sodium, etc .; phosphate ester salt (POE-oleyl ether sodium phosphate, POE-stearyl ether phosphate, etc.); sulfosuccinate (eg di Sodium 2-ethylhexyl sulfosuccinate, sodium monolauroyl monoethanolamide polyoxyethylene sodium sulfosuccinate, sodium lauryl polypropylene glycol sulfosuccinate, etc .; alkylbenzene sulfonates (for example, sodium lineardodecylbenzenesulfonate, triethanolamine lineardodecylbenzenesulfonate) Higher fatty acid ester sulfate (for example, hydrogenated coconut oil fatty acid sodium glyceryl sulfate, etc.); N-acyl glutamate (for example, monosodium N-lauroyl glutamate, disodium N-stearoyl glutamate, N-myristoyl-L-monosodium glutamate, etc.); sulfated oil (eg funnel oil); POE-alkyl Ether carboxylic acid; POE-alkyl allyl ether carboxylate; α-olefin sulfonate; higher fatty acid ester sulfonate; secondary alcohol sulfate ester; higher fatty acid alkylolamide sulfate ester; lauroyl monoethanolamide sodium succinate N-palmitoyl aspartate ditriethanolamine; sodium caseinate and the like.

In the said washing | cleaning material, the arbitrary component normally used with a washing | cleaning material other than the illustrated component can be contained. Examples of such optional ingredients include macadamia nut oil, avocado oil, corn oil, olive oil, rapeseed oil, sesame oil, castor oil, safflower oil, cottonseed oil, jojoba oil, coconut oil, palm oil, liquid lanolin, and hardened coconut oil. Oil, wax, oils such as beeswax, molasses, hydrogenated castor oil, beeswax, candelilla wax, carnauba wax, ibotarou, lanolin, reduced lanolin, hard lanolin, jojoba wax; , Hydrocarbons such as microcrystalline wax; higher fatty acids such as oleic acid, isostearic acid, lauric acid, myristic acid, palmitic acid, stearic acid, behenic acid, undecylenic acid; cetyl alcohol, stearyl alcohol, isostearyl Higher alcohols such as alcohol, behenyl alcohol, octyldodecanol, myristyl alcohol, cetostearyl alcohol; cetyl isooctanoate, isopropyl myristate, hexyldecyl isostearate, diisopropyl adipate, di-2-ethylhexyl sebacate, cetyl lactate, malic acid Diisostearyl, di-2-ethylhexanoic acid ethylene glycol, dicaprate neopentyl glycol, di-2-heptylundecanoic acid glycerin, tri-2-ethylhexanoic acid glycerin, tri-2-ethylhexanoic acid trimethylolpropane, tri Synthetic ester oils such as trimethylolpropane isostearate and pentane erythritol tetra-2-ethylhexanoate; dimethylpolysiloxane, methylphenylpoly Linear polysiloxanes such as oxane and diphenylpolysiloxane; cyclic polysiloxanes such as octamethylcyclotetrasiloxane, decamethylcyclopentasiloxane, and dodecamethylcyclohexanesiloxane; amino-modified polysiloxane, polyether-modified polysiloxane, alkyl-modified polysiloxane, Oil agents such as silicone oils such as modified polysiloxanes such as fluorine-modified polysiloxanes; Anionic surfactants such as fatty acid soap (sodium laurate, sodium palmitate, etc.), potassium lauryl sulfate, triethanolamine ether of alkyl sulfates; Cationic surfactants such as stearyltrimethylammonium, benzalkonium chloride, laurylamine oxide; imidazoline-based amphoteric surfactants (2-cocoyl-2-imida Zolinium hydroxide-1-carboxyethyloxy disodium salt, etc.), betaine surfactants (alkyl betaine, amide betaine, sulfobetaine, etc.), and amphoteric surfactants such as acylmethyltaurine; sorbitan fatty acid esters (sorbitan) Monostearate, sorbitan sesquioleate, etc.), glycerin fatty acids (eg, glyceryl monostearate), propylene glycol fatty acid esters (eg, propylene glycol monostearate), hardened castor oil derivatives, glycerin alkyl ethers, POE sorbitan fatty acid esters (POE sorbitan monooleate, polyoxyethylene sorbitan monostearate, etc.), POE sorbite fatty acid esters (POE-sorbitol monolaurate, etc.), POE glycerin fatty acid ester Tells (POE-glycerol monoisostearate, etc.), POE fatty acid esters (polyethylene glycol monooleate, POE distearate, etc.), POE alkyl ethers (POE2-octyldodecyl ether, etc.), POE alkylphenyl ethers (POE nonylphenyl) Ethers, etc.), Pluronic types, POE / POP alkyl ethers (POE / POP2-decyltetradecyl ether, etc.), Tetronics, POE castor oil / hardened castor oil derivatives (POE castor oil, POE hardened castor oil, etc.), Nonionic surfactants such as sucrose fatty acid esters and alkyl glucosides; acyl (poly) amino acids such as bis (N-lauroylglutamic acid) lysine and / or salts thereof; polyethylene glycol, glycerin, 1,3-buty Glycol, erythritol, sorbitol, xylitol, maltitol, propylene glycol, dipropylene glycol, diglycerin, isoprene glycol, 1,2-pentanediol, 2,4-hexanediol, 1,2-hexanediol, 1,2- Polyhydric alcohols such as octanediol; moisturizing ingredients such as sodium pyrrolidonecarboxylate, lactic acid, sodium lactate; surface-treated mica, talc, kaolin, synthetic mica, calcium carbonate, magnesium carbonate, anhydrous silica Powders such as acid (silica), aluminum oxide, barium sulfate, etc .; the surface may be treated, bengara, yellow iron oxide, black iron oxide, cobalt oxide, ultramarine, bitumen, titanium oxide, zinc oxide inorganic Pigments: Mica titanium whose surface may be treated Pearl agents such as fish phosphorus foil, bismuth oxychloride; red 202, red 228, red 226, yellow 4, blue 404, yellow 5, red 505, red, which may be raked Organic dyes such as 230, red 223, orange 201, red 213, yellow 204, yellow 203, blue 1, green 201, purple 201, red 204; polyethylene powder, polymethacrylic acid Organic powders such as methyl, nylon powder, organopolysiloxane elastomer; paraaminobenzoic acid UV absorbers; anthranilic acid UV absorbers; salicylic acid UV absorbers; cinnamic acid UV absorbers; benzophenone UV absorbers Agent; sugar ultraviolet absorber; 2- (2′-hydroxy-5′-t-octylphenyl) benzotriazole, 4-methoxy-4′-t UV absorbers such as butyldibenzoylmethane; lower alcohols such as ethanol and isopropanol; vitamin A or a derivative thereof, vitamin B6 hydrochloride, vitamin B6 tripalmitate, vitamin B6 dioctanoate, vitamin B2 or a derivative thereof, vitamin B12, Vitamin B such as vitamin B15 or a derivative thereof; vitamin E such as α-tocopherol, β-tocopherol, γ-tocopherol, vitamin E acetate, vitamin D, vitamin H, pantothenic acid, panthetin, pyrroloquinoline quinone Preferred examples include antibacterial agents such as phenoxyethanol.

The said washing | cleaning material points out what is applied to these skins for the purpose of washing | cleaning the skin for bodies, scalp and hair, a face, etc., The dosage form can also take a wide form, such as aqueous solution system, an emulsion system, and a gel system.

EXAMPLES Next, although an Example demonstrates this invention in detail, this invention is not limited by these. Test methods and evaluation methods employed in the examples will be described.

In Vivo Cleaning Test Using a human forearm inner part, a glass cup was attached, and a surfactant solution was applied to reproduce the cleaning liquid state. The amino acid elution amount and TEWL value were measured with or without N-acetylglucosamine with respect to the surfactant solution. At this time, potassium laurate was used as an anionic surfactant. The results of the amino acid elution amount are shown in FIG. Moreover, the result of the change amount of TEWL is shown in FIG. In any figure, LK represents potassium laurate and NAG represents N-acetylglucosamine. The amount of amino acid eluted was measured by HPLC (manufactured by Shimadzu Corporation) for the amount of amino acid in the washing solution. The column was Wakopak Wakosil-PTC (4.0 mm × 20.0 mm) (manufactured by Wako), and the mobile layer was PTC-Amino Acids Mobile Phase A, B (manufactured by WAko). TEWL conditioned the skin for 20 minutes before and after the cleaning test under the conditions of 22 ° C. and RH 50%. Measurement was performed using a TEWL measuring apparatus (Courage + Kazaka Electronic GmbH “Tewameter TM210”), and a difference between before and after (ΔTEWL) was calculated.

The obtained data was subjected to data significance test using t-test. * (P <0.05) at 5% significance level.

As is clear from the results shown in FIGS. 1 and 2, it can be seen that the coexistence of N-acetylglucosamine suppresses the change in TEWL before and after washing and suppresses elution of amino acids during washing.

Examples of the skin cleanser containing N-acetylglucosamine of the present invention are shown below. The composition is expressed in wt%.

Example 1 (body shampoo)
(%) Arginine of N-lauroyl-L-glutamate [10/12] 5.0 Arginine laurate 10.0 Arginine myristate 2.0 Palm oil fatty acid amidopropyl betaine 3.0 Dimethylpolysiloxane (1 1,000,000 cSt; 25 ° C.) 1.0. Dimethylpolysiloxane (100 cSt; 25 ° C.) 2.0. Ethylene glycol distearate 1.0. Propylene glycol 1.0. N-acetylglucosamine 1.0. Dye. Perfume proper amount / water adjustment

Example 2 (face washing foam)
(%) N-coconut oil fatty acid acyl-L-glutamic acid arginine [10/22] 20.0, arginine palmitate 5.0, arginine myristic acid 5.0, polyethylene glycol monostearate 1.0, polyoxyethylene Cetyl ether 1.0, new oil type glyceryl monostearate 1.0, glycerin 5.0, sorbitol 5.0, ethylene glycol distearate 3.0, polyethylene glycol 7.0, peach leaf extract 0.3, l- Menthol 0.1, Polyethylene powder 1.0, N-acetylglucosamine 1.0, Fragrance 0.5, Water adjustment

Example 3 (hand soap)
(%) N-lauroyl-L-glutamic acid arginine [10/20] 5.0, potassium myristate 6.0, potassium palmitate 2.0, POE (3) sodium lauryl ether sulfate 10.0 palm oil Fatty acid amidopropyl betaine 0.5
-Lauryldimethylamine oxide 2.0-Acrylamide-Acrylic acid-Dimethyldiallylammonium chloride copolymer liquid 5.0-Dimethyldiallylammonium chloride-acrylamide copolymer liquid 1.0-Ethylene glycol distearate 1.5-Hydroxyethyl cellulose 0. 3. Lemon extract 0.3. Carrot extract 0.1. Hydrolyzed silk solution 0.1. Glycerin 5.0. 1,3-butylene glycol 5.0. N-acetylglucosamine 1.0. EDTA 0.1. Triclosan 0.1 / Dye / Flavoring / Water / Water

(Comparative Examples 1-3)
Except not mix | blending N-acetylglucosamine, it carried out similarly to Examples 1-3, and obtained the body shampoo, face-wash foam, and hand soap of Comparative Examples 1-3. The usability of the cleaning materials of Examples and Comparative Examples was evaluated.

"Evaluation (1): Touch evaluation"
An actual use test was conducted by 10 expert panelists to evaluate the feel after washing.
◎ ... More than 8 professional panelists recognized that the feel after washing was good.
○ ... 6 or more and less than 8 professional panelists recognized that the feel after washing was good.
Δ: 3 or more and less than 6 professional panelists recognized that the feel after washing was good.
X: Less than 3 expert panelists recognized that the touch after washing was good.

"Evaluation (2): Cleaning effect"
An actual use test was conducted by 10 professional panelists to determine whether or not there was a cleaning effect after cleaning.
A: More than 8 professional panelists recognized that there was a cleaning effect after cleaning.
○… More than 6 panelists and less than 8 professional panelists recognized that there was a cleaning effect after cleaning.
Δ: 3 or more and less than 6 professional panelists recognized that there was a cleaning effect after cleaning.
X: Less than three professional panelists recognized that there was a cleaning effect after cleaning.

"Evaluation (3): Foaming during cleaning"
An actual use test was conducted by 10 expert panelists to determine whether or not foaming occurred during washing.
A: More than 8 professional panelists recognized that foaming was good during cleaning.
○… More than 6 expert panelists and less than 8 people recognized that foaming was good during cleaning.
Δ: 3 or more and less than 6 specialist panelists recognized that foaming was good during washing.
X: Less than 3 professional panelists recognized that foaming was good during washing.

Examples 1 to 3 of N-acetylglucosamine blending and cleaning agents of Comparative Examples 1 to 3 that are not blended are manufactured by a conventional method, and the above evaluations (1), (2), and (3) are subjected to an evaluation test. The results are shown in Table 1.

(Table 1)

The evaluation of touch is a comprehensive evaluation such as a refreshing feeling after washing, a moist feeling, a crispness, and a crispness. The cleaning materials shown in the examples had a better feel during use and after use than the comparative examples. This is considered to be a property that the amount of amino acid elution from the skin by the surfactant is low, there is no protein denaturation, and the water retention amount of the skin after washing is large.

Regarding detergency and foaming, the low elution amount of amino acids is considered not to have a detrimental effect on the detergency, and is thought not to have any effect on the inhibition of foaming.

Claims (1)

An amino acid elution inhibitor that suppresses elution of skin amino acids during washing with a surfactant, comprising N-acetylglucosamine as an active ingredient.