JPH0278611A - Skin cleaning agent - Google Patents
Skin cleaning agentInfo
- Publication number
- JPH0278611A JPH0278611A JP22909788A JP22909788A JPH0278611A JP H0278611 A JPH0278611 A JP H0278611A JP 22909788 A JP22909788 A JP 22909788A JP 22909788 A JP22909788 A JP 22909788A JP H0278611 A JPH0278611 A JP H0278611A
- Authority
- JP
- Japan
- Prior art keywords
- skin
- ascorbic acid
- acid
- kojic acid
- kojic
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000012459 cleaning agent Substances 0.000 title abstract description 6
- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 claims abstract description 48
- BEJNERDRQOWKJM-UHFFFAOYSA-N kojic acid Chemical compound OCC1=CC(=O)C(O)=CO1 BEJNERDRQOWKJM-UHFFFAOYSA-N 0.000 claims abstract description 40
- WZNJWVWKTVETCG-UHFFFAOYSA-N kojic acid Natural products OC(=O)C(N)CN1C=CC(=O)C(O)=C1 WZNJWVWKTVETCG-UHFFFAOYSA-N 0.000 claims abstract description 29
- 229960004705 kojic acid Drugs 0.000 claims abstract description 29
- 235000010323 ascorbic acid Nutrition 0.000 claims abstract description 25
- 239000011668 ascorbic acid Substances 0.000 claims abstract description 24
- 229960005070 ascorbic acid Drugs 0.000 claims abstract description 21
- 150000000996 L-ascorbic acids Chemical class 0.000 claims abstract description 15
- 125000003289 ascorbyl group Chemical class [H]O[C@@]([H])(C([H])([H])O*)[C@@]1([H])OC(=O)C(O*)=C1O* 0.000 claims 1
- 230000000694 effects Effects 0.000 abstract description 17
- 230000002087 whitening effect Effects 0.000 abstract description 12
- 206010014970 Ephelides Diseases 0.000 abstract description 10
- 208000003351 Melanosis Diseases 0.000 abstract description 10
- 238000004140 cleaning Methods 0.000 abstract description 4
- 230000002195 synergetic effect Effects 0.000 abstract description 4
- 150000003839 salts Chemical class 0.000 abstract 2
- 239000003795 chemical substances by application Substances 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 239000000344 soap Substances 0.000 description 18
- 239000006071 cream Substances 0.000 description 14
- 239000003599 detergent Substances 0.000 description 12
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 description 9
- 239000002537 cosmetic Substances 0.000 description 9
- 239000007788 liquid Substances 0.000 description 9
- 150000000994 L-ascorbates Chemical class 0.000 description 7
- 239000006260 foam Substances 0.000 description 7
- 239000003205 fragrance Substances 0.000 description 6
- -1 packs Substances 0.000 description 6
- 239000011786 L-ascorbyl-6-palmitate Substances 0.000 description 5
- 239000004166 Lanolin Substances 0.000 description 5
- 230000002354 daily effect Effects 0.000 description 5
- 230000001815 facial effect Effects 0.000 description 5
- 238000009472 formulation Methods 0.000 description 5
- 235000019388 lanolin Nutrition 0.000 description 5
- 229940039717 lanolin Drugs 0.000 description 5
- 239000000203 mixture Substances 0.000 description 5
- TVMQDNRQQWQICK-UHFFFAOYSA-M sodium;6-(hydroxymethyl)-4-oxopyran-3-olate Chemical compound [Na+].OCC1=CC(=O)C([O-])=CO1 TVMQDNRQQWQICK-UHFFFAOYSA-M 0.000 description 5
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 5
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 4
- QAQJMLQRFWZOBN-LAUBAEHRSA-N L-ascorbyl-6-palmitate Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@H](O)[C@H]1OC(=O)C(O)=C1O QAQJMLQRFWZOBN-LAUBAEHRSA-N 0.000 description 4
- 206010040829 Skin discolouration Diseases 0.000 description 4
- 238000003287 bathing Methods 0.000 description 4
- POULHZVOKOAJMA-UHFFFAOYSA-N dodecanoic acid Chemical compound CCCCCCCCCCCC(O)=O POULHZVOKOAJMA-UHFFFAOYSA-N 0.000 description 4
- 239000004615 ingredient Substances 0.000 description 4
- 239000006210 lotion Substances 0.000 description 4
- 238000000034 method Methods 0.000 description 4
- 239000002674 ointment Substances 0.000 description 4
- 239000003755 preservative agent Substances 0.000 description 4
- 239000008213 purified water Substances 0.000 description 4
- 235000010378 sodium ascorbate Nutrition 0.000 description 4
- 229960005055 sodium ascorbate Drugs 0.000 description 4
- PPASLZSBLFJQEF-RKJRWTFHSA-M sodium ascorbate Substances [Na+].OC[C@@H](O)[C@H]1OC(=O)C(O)=C1[O-] PPASLZSBLFJQEF-RKJRWTFHSA-M 0.000 description 4
- PPASLZSBLFJQEF-RXSVEWSESA-M sodium-L-ascorbate Chemical compound [Na+].OC[C@H](O)[C@H]1OC(=O)C(O)=C1[O-] PPASLZSBLFJQEF-RXSVEWSESA-M 0.000 description 4
- 238000005406 washing Methods 0.000 description 4
- CSTRPYAGFNTOEQ-MGMRMFRLSA-N (2r)-2-[(1s)-1,2-dihydroxyethyl]-3,4-dihydroxy-2h-furan-5-one;octadecanoic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O.CCCCCCCCCCCCCCCCCC(O)=O CSTRPYAGFNTOEQ-MGMRMFRLSA-N 0.000 description 3
- 235000000072 L-ascorbyl-6-palmitate Nutrition 0.000 description 3
- KWYUFKZDYYNOTN-UHFFFAOYSA-M Potassium hydroxide Chemical compound [OH-].[K+] KWYUFKZDYYNOTN-UHFFFAOYSA-M 0.000 description 3
- 239000002253 acid Substances 0.000 description 3
- 229940072107 ascorbate Drugs 0.000 description 3
- 235000014113 dietary fatty acids Nutrition 0.000 description 3
- 239000000839 emulsion Substances 0.000 description 3
- 238000011156 evaluation Methods 0.000 description 3
- 239000000194 fatty acid Substances 0.000 description 3
- 229930195729 fatty acid Natural products 0.000 description 3
- 239000000463 material Substances 0.000 description 3
- 239000003352 sequestering agent Substances 0.000 description 3
- VBICKXHEKHSIBG-UHFFFAOYSA-N 1-monostearoylglycerol Chemical compound CCCCCCCCCCCCCCCCCC(=O)OCC(O)CO VBICKXHEKHSIBG-UHFFFAOYSA-N 0.000 description 2
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 2
- 239000005639 Lauric acid Substances 0.000 description 2
- 235000021355 Stearic acid Nutrition 0.000 description 2
- GSEJCLTVZPLZKY-UHFFFAOYSA-N Triethanolamine Chemical class OCCN(CCO)CCO GSEJCLTVZPLZKY-UHFFFAOYSA-N 0.000 description 2
- 235000010385 ascorbyl palmitate Nutrition 0.000 description 2
- MOTZDAYCYVMXPC-UHFFFAOYSA-N dodecyl hydrogen sulfate Chemical compound CCCCCCCCCCCCOS(O)(=O)=O MOTZDAYCYVMXPC-UHFFFAOYSA-N 0.000 description 2
- 229940043264 dodecyl sulfate Drugs 0.000 description 2
- 150000004665 fatty acids Chemical class 0.000 description 2
- 235000011187 glycerol Nutrition 0.000 description 2
- IPCSVZSSVZVIGE-UHFFFAOYSA-N hexadecanoic acid Chemical compound CCCCCCCCCCCCCCCC(O)=O IPCSVZSSVZVIGE-UHFFFAOYSA-N 0.000 description 2
- 238000002156 mixing Methods 0.000 description 2
- QIQXTHQIDYTFRH-UHFFFAOYSA-N octadecanoic acid Chemical compound CCCCCCCCCCCCCCCCCC(O)=O QIQXTHQIDYTFRH-UHFFFAOYSA-N 0.000 description 2
- OQCDKBAXFALNLD-UHFFFAOYSA-N octadecanoic acid Natural products CCCCCCCC(C)CCCCCCCCC(O)=O OQCDKBAXFALNLD-UHFFFAOYSA-N 0.000 description 2
- 239000003921 oil Substances 0.000 description 2
- 235000019198 oils Nutrition 0.000 description 2
- 239000000843 powder Substances 0.000 description 2
- 230000002335 preservative effect Effects 0.000 description 2
- 230000002265 prevention Effects 0.000 description 2
- 230000001603 reducing effect Effects 0.000 description 2
- 230000001953 sensory effect Effects 0.000 description 2
- 229910052708 sodium Inorganic materials 0.000 description 2
- 239000011734 sodium Substances 0.000 description 2
- 239000013042 solid detergent Substances 0.000 description 2
- PRAKJMSDJKAYCZ-UHFFFAOYSA-N squalane Chemical compound CC(C)CCCC(C)CCCC(C)CCCCC(C)CCCC(C)CCCC(C)C PRAKJMSDJKAYCZ-UHFFFAOYSA-N 0.000 description 2
- 239000008117 stearic acid Substances 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
- 229940088594 vitamin Drugs 0.000 description 2
- 229930003231 vitamin Natural products 0.000 description 2
- 235000013343 vitamin Nutrition 0.000 description 2
- 239000011782 vitamin Substances 0.000 description 2
- ALSTYHKOOCGGFT-KTKRTIGZSA-N (9Z)-octadecen-1-ol Chemical compound CCCCCCCC\C=C/CCCCCCCCO ALSTYHKOOCGGFT-KTKRTIGZSA-N 0.000 description 1
- WRIDQFICGBMAFQ-UHFFFAOYSA-N (E)-8-Octadecenoic acid Natural products CCCCCCCCCC=CCCCCCCC(O)=O WRIDQFICGBMAFQ-UHFFFAOYSA-N 0.000 description 1
- TWJNQYPJQDRXPH-UHFFFAOYSA-N 2-cyanobenzohydrazide Chemical compound NNC(=O)C1=CC=CC=C1C#N TWJNQYPJQDRXPH-UHFFFAOYSA-N 0.000 description 1
- LQJBNNIYVWPHFW-UHFFFAOYSA-N 20:1omega9c fatty acid Natural products CCCCCCCCCCC=CCCCCCCCC(O)=O LQJBNNIYVWPHFW-UHFFFAOYSA-N 0.000 description 1
- QSBYPNXLFMSGKH-UHFFFAOYSA-N 9-Heptadecensaeure Natural products CCCCCCCC=CCCCCCCCC(O)=O QSBYPNXLFMSGKH-UHFFFAOYSA-N 0.000 description 1
- 239000005995 Aluminium silicate Substances 0.000 description 1
- 241000228212 Aspergillus Species 0.000 description 1
- KCXVZYZYPLLWCC-UHFFFAOYSA-N EDTA Chemical compound OC(=O)CN(CC(O)=O)CCN(CC(O)=O)CC(O)=O KCXVZYZYPLLWCC-UHFFFAOYSA-N 0.000 description 1
- FYYHWMGAXLPEAU-UHFFFAOYSA-N Magnesium Chemical compound [Mg] FYYHWMGAXLPEAU-UHFFFAOYSA-N 0.000 description 1
- 235000021360 Myristic acid Nutrition 0.000 description 1
- TUNFSRHWOTWDNC-UHFFFAOYSA-N Myristic acid Natural products CCCCCCCCCCCCCC(O)=O TUNFSRHWOTWDNC-UHFFFAOYSA-N 0.000 description 1
- AOMUHOFOVNGZAN-UHFFFAOYSA-N N,N-bis(2-hydroxyethyl)dodecanamide Chemical compound CCCCCCCCCCCC(=O)N(CCO)CCO AOMUHOFOVNGZAN-UHFFFAOYSA-N 0.000 description 1
- 239000005642 Oleic acid Substances 0.000 description 1
- ZQPPMHVWECSIRJ-UHFFFAOYSA-N Oleic acid Natural products CCCCCCCCC=CCCCCCCCC(O)=O ZQPPMHVWECSIRJ-UHFFFAOYSA-N 0.000 description 1
- 229910019142 PO4 Inorganic materials 0.000 description 1
- 235000021314 Palmitic acid Nutrition 0.000 description 1
- 241000286209 Phasianidae Species 0.000 description 1
- 229920003171 Poly (ethylene oxide) Polymers 0.000 description 1
- 239000002202 Polyethylene glycol Substances 0.000 description 1
- ZLMJMSJWJFRBEC-UHFFFAOYSA-N Potassium Chemical compound [K] ZLMJMSJWJFRBEC-UHFFFAOYSA-N 0.000 description 1
- 239000004260 Potassium ascorbate Substances 0.000 description 1
- KEAYESYHFKHZAL-UHFFFAOYSA-N Sodium Chemical compound [Na] KEAYESYHFKHZAL-UHFFFAOYSA-N 0.000 description 1
- QAOWNCQODCNURD-UHFFFAOYSA-L Sulfate Chemical compound [O-]S([O-])(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-L 0.000 description 1
- 206010042496 Sunburn Diseases 0.000 description 1
- GWEVSGVZZGPLCZ-UHFFFAOYSA-N Titan oxide Chemical compound O=[Ti]=O GWEVSGVZZGPLCZ-UHFFFAOYSA-N 0.000 description 1
- 230000002378 acidificating effect Effects 0.000 description 1
- 239000000654 additive Substances 0.000 description 1
- 235000012211 aluminium silicate Nutrition 0.000 description 1
- 235000013871 bee wax Nutrition 0.000 description 1
- 239000012166 beeswax Substances 0.000 description 1
- 238000004061 bleaching Methods 0.000 description 1
- 239000003518 caustics Substances 0.000 description 1
- 229960000541 cetyl alcohol Drugs 0.000 description 1
- ALSTYHKOOCGGFT-UHFFFAOYSA-N cis-oleyl alcohol Natural products CCCCCCCCC=CCCCCCCCCO ALSTYHKOOCGGFT-UHFFFAOYSA-N 0.000 description 1
- 239000002781 deodorant agent Substances 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 239000003623 enhancer Substances 0.000 description 1
- 230000003203 everyday effect Effects 0.000 description 1
- 238000000605 extraction Methods 0.000 description 1
- 238000000855 fermentation Methods 0.000 description 1
- 230000004151 fermentation Effects 0.000 description 1
- 239000000499 gel Substances 0.000 description 1
- 125000005456 glyceride group Chemical group 0.000 description 1
- 229940075507 glyceryl monostearate Drugs 0.000 description 1
- BXWNKGSJHAJOGX-UHFFFAOYSA-N hexadecan-1-ol Chemical compound CCCCCCCCCCCCCCCCO BXWNKGSJHAJOGX-UHFFFAOYSA-N 0.000 description 1
- IPCSVZSSVZVIGE-UHFFFAOYSA-M hexadecanoate Chemical compound CCCCCCCCCCCCCCCC([O-])=O IPCSVZSSVZVIGE-UHFFFAOYSA-M 0.000 description 1
- 239000003906 humectant Substances 0.000 description 1
- 230000000774 hypoallergenic effect Effects 0.000 description 1
- QXJSBBXBKPUZAA-UHFFFAOYSA-N isooleic acid Natural products CCCCCCCC=CCCCCCCCCC(O)=O QXJSBBXBKPUZAA-UHFFFAOYSA-N 0.000 description 1
- NLYAJNPCOHFWQQ-UHFFFAOYSA-N kaolin Chemical compound O.O.O=[Al]O[Si](=O)O[Si](=O)O[Al]=O NLYAJNPCOHFWQQ-UHFFFAOYSA-N 0.000 description 1
- 125000000400 lauroyl group Chemical group O=C([*])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
- 239000011777 magnesium Substances 0.000 description 1
- 229910052749 magnesium Inorganic materials 0.000 description 1
- 239000002075 main ingredient Substances 0.000 description 1
- 229910052751 metal Inorganic materials 0.000 description 1
- 239000002184 metal Substances 0.000 description 1
- 244000005700 microbiome Species 0.000 description 1
- 239000001788 mono and diglycerides of fatty acids Substances 0.000 description 1
- WQEPLUUGTLDZJY-UHFFFAOYSA-N n-Pentadecanoic acid Natural products CCCCCCCCCCCCCCC(O)=O WQEPLUUGTLDZJY-UHFFFAOYSA-N 0.000 description 1
- JXTPJDDICSTXJX-UHFFFAOYSA-N n-Triacontane Natural products CCCCCCCCCCCCCCCCCCCCCCCCCCCCCC JXTPJDDICSTXJX-UHFFFAOYSA-N 0.000 description 1
- 230000007935 neutral effect Effects 0.000 description 1
- 230000037311 normal skin Effects 0.000 description 1
- ZQPPMHVWECSIRJ-KTKRTIGZSA-N oleic acid Chemical compound CCCCCCCC\C=C/CCCCCCCC(O)=O ZQPPMHVWECSIRJ-KTKRTIGZSA-N 0.000 description 1
- 239000004006 olive oil Substances 0.000 description 1
- 235000008390 olive oil Nutrition 0.000 description 1
- 239000003960 organic solvent Substances 0.000 description 1
- 239000010452 phosphate Substances 0.000 description 1
- 239000000049 pigment Substances 0.000 description 1
- 229920001223 polyethylene glycol Polymers 0.000 description 1
- 229910052700 potassium Inorganic materials 0.000 description 1
- 239000011591 potassium Substances 0.000 description 1
- 235000019275 potassium ascorbate Nutrition 0.000 description 1
- 229940017794 potassium ascorbate Drugs 0.000 description 1
- CONVKSGEGAVTMB-RXSVEWSESA-M potassium-L-ascorbate Chemical compound [K+].OC[C@H](O)[C@H]1OC(=O)C(O)=C1[O-] CONVKSGEGAVTMB-RXSVEWSESA-M 0.000 description 1
- 230000005855 radiation Effects 0.000 description 1
- 239000002994 raw material Substances 0.000 description 1
- 238000001953 recrystallisation Methods 0.000 description 1
- FSYKKLYZXJSNPZ-UHFFFAOYSA-N sarcosine Chemical group C[NH2+]CC([O-])=O FSYKKLYZXJSNPZ-UHFFFAOYSA-N 0.000 description 1
- UQDJGEHQDNVPGU-UHFFFAOYSA-N serine phosphoethanolamine Chemical compound [NH3+]CCOP([O-])(=O)OCC([NH3+])C([O-])=O UQDJGEHQDNVPGU-UHFFFAOYSA-N 0.000 description 1
- 239000002453 shampoo Substances 0.000 description 1
- 230000037075 skin appearance Effects 0.000 description 1
- 159000000000 sodium salts Chemical class 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 229940032094 squalane Drugs 0.000 description 1
- 238000010189 synthetic method Methods 0.000 description 1
- 239000000454 talc Substances 0.000 description 1
- 229910052623 talc Inorganic materials 0.000 description 1
- 235000012222 talc Nutrition 0.000 description 1
- 235000010215 titanium dioxide Nutrition 0.000 description 1
- 229920003169 water-soluble polymer Polymers 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/02—Preparations for care of the skin for chemically bleaching or whitening the skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
- A61K8/4973—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with oxygen as the only hetero atom
- A61K8/498—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with oxygen as the only hetero atom having 6-membered rings or their condensed derivatives, e.g. coumarin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/67—Vitamins
- A61K8/676—Ascorbic acid, i.e. vitamin C
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Birds (AREA)
- Epidemiology (AREA)
- Dermatology (AREA)
- Cosmetics (AREA)
- Detergent Compositions (AREA)
Abstract
Description
【発明の詳細な説明】
［産業上の利用分野］
本発明は、コウジ酸またはコウジ酸塩配合皮膚洗浄料に
アスコルビン酸またはアスコルビン酸塩、アスコルビン
酸誘導体を配合し、コウジ酸とアスコルビン酸の相乗効
果により色白効果を高めることができる皮膚洗浄料に関
するものである。Detailed Description of the Invention [Industrial Application Field] The present invention involves blending ascorbic acid, an ascorbate salt, or an ascorbic acid derivative into a skin cleanser containing kojic acid or a kojic acid salt, thereby achieving a synergistic effect between kojic acid and ascorbic acid. The present invention relates to a skin cleansing agent that can enhance skin whitening effects.
［従来の技術］
従来、コウジ酸は、漂白１色白効果を有する成分として
知られ、色白成分として軟膏、あるいは、クリーム類、
パック類、乳液・乳剤類、ローション類等の化粧料に配
合され、効果を発揮している（特公昭３２−８１００、
特開昭５３−３５３８、特公昭６１−１０４４７号広報
など）。[Prior Art] Kojic acid has conventionally been known as a component that has bleaching and skin-lightening effects, and is used as a skin-lightening component in ointments, creams,
It has been incorporated into cosmetics such as packs, emulsions, emulsions, lotions, etc. and has been shown to be effective (Special Publication No. 32-8100,
(Japanese Patent Application Publication No. 53-3538, Publication No. 10447 of 1983, etc.)
また、アスコルビン酸またはアスコルビン酸塩、アスコ
ルビン酸誘導体も、色白効果を有する成分として古くか
ら知られている。（骨内はか、ビタミン、２８巻、５０
１頁、１９６３）コウジ酸、コウジ酸塩、アスコルビン
酸、アスコルビン酸塩、アスコルビン酸誘導体から選ば
れる少なくとも１種を含有する軟膏及び化粧料は、一般
に顔、身体の一部に塗布され、主に顔、身体の一部に生
じるシミ、ソバカス等の防止のために用いられている。Furthermore, ascorbic acid, ascorbate salts, and ascorbic acid derivatives have long been known as ingredients that have a skin-whitening effect. (Intraosseous tissue, vitamins, vol. 28, 50
1, 1963) Ointments and cosmetics containing at least one selected from kojic acid, kojic acid salts, ascorbic acid, ascorbates, and ascorbic acid derivatives are generally applied to the face and other parts of the body, and are mainly used for It is used to prevent spots and freckles that appear on the face and parts of the body.
ところがシミ、ソバカスは全身に生ずるものであり、こ
れら軟膏、化粧料を全身に塗布することは実際上むつか
しい、また、化粧料をあまり使用しない女性、及び子供
や男性などはこれらの軟膏やクリーム、バック等の化粧
料を日常的に使用することを好まない、そこで、日常的
に簡単な方法により、顔・全身のシミ、ソバカスの発生
防止効果、顔・全身の肌の色白効果、日光浴で生じた日
焼は後のシミ・ソバカスの発生防止効果、顔・全身を温
和に正常な皮膚の色に戻す効果等が得られる皮膚洗浄料
が求められている。However, spots and freckles occur all over the body, and it is actually difficult to apply these ointments and cosmetics all over the body.Furthermore, women, children, and men who do not use cosmetics often do not use these ointments, creams, or cosmetics. People who don't like to use cosmetics such as bags on a daily basis can use a simple method to prevent the appearance of spots and freckles on the face and whole body, whiten the skin of the face and whole body, and improve skin appearance caused by sunbathing. There is a need for a skin cleansing agent that has the effect of preventing the appearance of spots and freckles after sunburn, as well as the effect of gently returning the face and whole body to its normal skin color.
本発明者らは、前記した効果を発揮する皮膚洗浄料を開
発すべく、コウジ酸またはコウジ酸塩を皮膚洗浄料に配
合したところ、色白効果が見られシミ・ソバカスの防止
等に効果があることを確認したが、コウジ酸またはコウ
ジ酸塩のみでは、その色白効果は弱く、皮膚洗浄料を毎
日使用しても効果が現われるまでに１ケ月以上もかかる
という欠点があることがわかった。アスコルビン酸、ア
スコルビン酸塩、アスコルビン酸誘導体もコウジ酸同様
色白効果が見られるが、その色白効果はコウジ酸よりも
弱かった。In order to develop a skin cleansing agent that exhibits the above-mentioned effects, the present inventors added kojic acid or kojic acid salts to a skin cleansing agent, which resulted in a skin whitening effect and was effective in preventing age spots and freckles. However, it was found that using kojic acid or kojic acid salt alone has a weak skin whitening effect, and that it takes more than a month for the effect to appear even if the skin cleanser is used daily. Like kojic acid, ascorbic acid, ascorbate salts, and ascorbic acid derivatives also have a skin-lightening effect, but the skin-lightening effect was weaker than that of kojic acid.
そこで、本発明者らは、さらに色白効果が優れ、前記し
た効果を発揮する皮膚洗浄料を開発すべく鋭意研究を重
ねた結果、コウジ酸またはコウジ酸塩を配合せしめた皮
膚洗浄料に、アスコルビン酸またはアスコルビン酸塩、
アスコルビン酸誘導体を配合し、コウジ酸とアスコルビ
ン酸の相乗効果°により、さらに高い色白効果を得るこ
とができることを見い出し、本発明を完成するに至った
。Therefore, the present inventors have conducted intensive research to develop a skin cleansing agent that has an even better skin whitening effect and exhibits the above-mentioned effects.As a result, the present inventors have found that ascorbic acid or ascorbate,
The present inventors have discovered that an even higher skin whitening effect can be obtained by blending an ascorbic acid derivative and the synergistic effect of kojic acid and ascorbic acid, leading to the completion of the present invention.
すなわち、本発明は、コウジ酸またはコウジ酸塩と、ア
スコルビン酸、アスコルビン酸塩およびアスコルビン酸
誘導体から選ばれる少なくとも１種を含有することを特
徴とする皮膚洗浄料に関するものである。That is, the present invention relates to a skin cleanser characterized by containing kojic acid or kojic acid salts and at least one selected from ascorbic acid, ascorbate salts, and ascorbic acid derivatives.
以下に本発明の詳細な説明する。The present invention will be explained in detail below.
本発明に適用されるコウジ酸は、化学名が５−オキシ−
２−才キジメチル−γ−ピロンＣＣ６Ｈ、０４）であり
、主として、アスペルギルス属等の微生物の発酵液より
抽出又は再結晶等を行なって得られるものであるが、も
ちろん合成的手法によって得られるものも使用可能であ
る。Kojic acid applied to the present invention has a chemical name of 5-oxy-
2-year-old pheasant methyl-γ-pyrone CC6H, 04) is obtained mainly by extraction or recrystallization from the fermentation liquid of microorganisms such as Aspergillus, but of course it can also be obtained by synthetic methods. Available for use.
本発明においてはコウジ酸だけでなくコウジ酸塩も用い
ることができる。In the present invention, not only kojic acid but also kojic acid salts can be used.
本発明に使用するアスコルビン酸、アスコルビン酸塩お
よびアスコルビン酸誘導体は、０体、Ｌ体、ラセミ体の
どれを用いてもかまわない。アスコルビン酸塩としては
、アスコルビン酸ナトリウム、アスコルビン酸カリウム
が一般に用いられるが、還元作用があり、色白効果が認
められるものであれば特に指定されるものではない。ま
たアスコルビン酸誘導体としては、脂溶性のアスコルビ
ン酸パルミチン酸エステル、アスコルビン酸ステアリン
酸エステル、アスコルビン酸２．６パルミテート、アス
コルビン酸の安定な誘導体として３位のＯＨ基をリン酸
エステル化したアスコルビン酸−３−リン酸エステルマ
グネシウムなどが一般的に用いられるが、還元作用があ
り、色白効果が認められるものであれば特に指定される
ものではない。Ascorbic acid, ascorbate, and ascorbic acid derivatives used in the present invention may be any of the 0-form, L-form, and racemic form. As the ascorbate salt, sodium ascorbate and potassium ascorbate are generally used, but as long as it has a reducing effect and a skin whitening effect is observed, it is not particularly specified. Examples of ascorbic acid derivatives include fat-soluble ascorbic acid palmitate, ascorbic acid stearate, ascorbic acid 2.6 palmitate, and ascorbic acid as a stable derivative of ascorbic acid in which the 3-OH group is phosphorylated. Magnesium 3-phosphate ester or the like is generally used, but it is not particularly specified as long as it has a reducing effect and has a whitening effect.
本発明により提供される皮膚洗浄料は、顔、全身を洗浄
するための洗浄料を言う０例えば、化粧石けん、透明石
けん、浮石けん、薬用石けん、デオドラント石けんなど
の固形洗浄料、さらにはコンバーあるいは、シンプツト
バーと呼ばれる脂肪酸モＱグリセリド硫酸、脂肪酸メタ
ルタウリッド、脂肪酸イセチオン酸エステル、ドデシル
硫酸などのナトリウム塩をそれぞれ主原料として単独、
あるいは石けんに配合した中性の固形洗浄料、Ｎ−アシ
ルグルタミン酸モノナトリウム塩を主剤とした弱酸性の
低刺激性固形洗浄料、ラウリル硫酸エステルのトリエタ
ノールアミン塩、ラウリルポリオキシエチレン硫酸エス
テルのラウロイルサルコシン塩などを主剤とし、一般に
°゛ボデイーシヤンプー°゛゛°洗浄料°°゛°全身洗
浄料゛。The skin cleansing agent provided by the present invention refers to a cleansing agent for cleaning the face and whole body.For example, solid cleaning agents such as cosmetic soap, transparent soap, floating soap, medicated soap, and deodorant soap, as well as combor and , fatty acid mo-Q glyceride sulfate, fatty acid metal tauride, fatty acid isethionate ester, dodecyl sulfate and other sodium salts are used as main raw materials.
Or a neutral solid detergent blended into soap, a weakly acidic hypoallergenic solid detergent based on monosodium N-acylglutamate, triethanolamine salt of lauryl sulfate, lauroyl polyoxyethylene sulfate The main ingredient is sarcosine salt, etc., and it is generally used as a body shampoo.
と称される液状又はクリーム状洗浄料、特殊舞台化粧料
の洗浄に用いられる有機溶剤含有の液体クレンジング、
無水油性クリームで、映画・演劇などで使用されるドー
ランをおとすために使われるリクイファイングクリーム
、メイクアップ化粧の主流を占めている油性化粧料をお
とすのに適しているＷ２Ｏ型及びＯ／Ｗ型クレンジング
クリーム、クレンジングクリームを乳液状にした乳化系
クレンジングローション、化粧水クイブのクレンジング
ローション、石けんの洗浄作用を保持しながら、メイク
アップや肌のよごれを洗いおとすクレンジングフオーム
などである。皮膚洗浄料は、特にその成分を指定される
ものではなく、顔・全身の洗浄に用いられるものであれ
ばよい、また皮膚洗浄料は、顔・全身の洗浄に用いられ
るものであれば、固形、液状、クリーム状、乳液状、泡
状、ゲル状、粉末状のいずれでもよい。liquid or cream-like cleansing agents, liquid cleansers containing organic solvents used for cleaning special stage cosmetics,
Anhydrous oil-based cream that is suitable for removing oil-based cosmetics used in movies and plays, as well as W2O type and O/W. These products include molded cleansing creams, emulsified cleansing lotions made from emulsified cleansing creams, cleansing lotions from Quive lotion, and cleansing foams that remove make-up and dirt from the skin while retaining the cleansing properties of soap. The ingredients of skin cleansing agents are not specified in particular, and any skin cleansing agent that is used for cleaning the face and whole body may be used. It may be in the form of liquid, cream, emulsion, foam, gel, or powder.
皮膚洗浄料には、−射的な成分や添加剤を必要に応じて
配合することはもちろん、従来から公知の使用性向上剤
を併用することも可能である。すなわち、ラノリン等の
油性成分、プロピレングリコール等の保湿剤、水溶性高
分子物質、タルク、カオリン、チタン白等の粉末類、ビ
タミン等の薬剤、防腐剤、金属イオン封鎖剤、殺菌剤９
色素。The skin cleansing agent may not only contain radiation ingredients and additives as necessary, but also use conventionally known usability enhancers. In other words, oily ingredients such as lanolin, humectants such as propylene glycol, water-soluble polymer substances, powders such as talc, kaolin, and titanium white, drugs such as vitamins, preservatives, sequestrants, and bactericides9.
Pigment.
香料等を含有せしめることができる。当然のことながら
、これらは本発明の効果を損なわない質的・量的範囲内
で使用されなければならな、い。It can contain fragrances and the like. Naturally, these must be used within a qualitative and quantitative range that does not impair the effects of the present invention.
前記のコウジ酸、コウジ酸塩とアスコルビン酸、アスコ
ルビン酸誘導体とは、どのような組み合わせで用いても
かまわない。また、組み合わせが１種類と１種類、１種
類と多種類、多種類と１種類、多種類と多種類であって
もかまわない。The above-mentioned kojic acid, kojic acid salts, ascorbic acid, and ascorbic acid derivatives may be used in any combination. Moreover, the combination may be one type and one type, one type and many types, many types and one type, or many types and many types.
コウジ酸およびアスコルビン酸の配合量は、皮膚洗浄料
の性質に応じて任意に選択されるが、通常は該皮膚洗浄
材全重量に対しコウジ酸またはコウジ酸塩が０．００２
〜１５重量％、好ましくは、０．１５〜５．０重量％、
アスコルビン酸、アスコルビン酸塩、アスコルビン酸誘
導体の配合量は、一般には０．０１〜１５重量％、好ま
しくは、０．４〜５．０重量％の範囲である。かかる特
定範囲内でコウジ酸、コウジ酸塩およびアスコルビン酸
、アスコルビン酸塩、アスコルビン酸誘導体を配合した
場合、それぞれを単独で用いるよりも、より大きい色白
効果を得ることができる。The amount of kojic acid and ascorbic acid to be blended is arbitrarily selected depending on the properties of the skin cleansing material, but usually the amount of kojic acid or kojic acid salt is 0.002% of the total weight of the skin cleansing material.
~15% by weight, preferably 0.15-5.0% by weight,
The amount of ascorbic acid, ascorbate, and ascorbic acid derivatives is generally in the range of 0.01 to 15% by weight, preferably 0.4 to 5.0% by weight. When kojic acid, kojic acid salts, ascorbic acid, ascorbate salts, and ascorbic acid derivatives are blended within such specific ranges, a greater skin whitening effect can be obtained than when each is used alone.
皮膚洗浄料は、主に入浴・洗顔などに恒常的に使用され
るものである。使用後、水等によって洗い落とされるた
めに、シミ・ソバカスの予防・除去、顔・全身の肌の色
白効果は、温和に現われる。しかしながら、恒常的に使
用することで、その効果を顕著に得ることができる。Skin cleansers are used regularly for bathing, face washing, etc. After use, it is washed off with water, etc., so the prevention and removal of stains and freckles and the whitening effect on the skin of the face and whole body appear mildly. However, by using it regularly, its effects can be significantly obtained.
［実施例］
以下本発明を実施例によって示すが、本発明はもとより
これらの実施例のみに限定されるものではない。[Examples] The present invention will be illustrated below by Examples, but the present invention is not limited to these Examples.
実施例１ （固形石けん）
ラノリン ２．５重量％オリーブ
油 ４．０コウジ酸
１．０アスコルビン酸 １．０
エチレンジアミン四酢酸 適量香料
適量実施例２ （液状全身洗浄料）
ラウリン酸 ２．５重量％ミリスチ
ン酸 ７．５パルミチン酸
２．５オレイン酸 ２・
５ラウロイルジエタノールアミド ５．０重量％プロ
ピレングリコール １Ｏ１０グリセリン
５，０
砂糖 ５．０苛性カリ
３．６コウジ酸ナトリウム
０．５香料 適量染料
適量防腐剤
適量金属イオン封鎖剤
適量精製水 ５５．４実施例３
（クレンジングフオーム）
ステアリン酸 １０００重量％バルミチ
ン酸 １０．０ミルスチン酸
１２．０ラウリン酸 ４．
０オレインアルコール １．５ラノリン誘導
体 １．０グリセリン
１８．０重量％水酸化カリウム ６．
０コウジ酸 １．０アスコルビン
酸ナトリウム ｌＯ
香料 ０． ５防腐剤
適量精製水
３５．０実施例４ （クリーム状洗顔石けん）
ラウロイルジェタノールアミド ５，０グリセリンモノ
パルミチン酸
エステル １．０ラノリン誘導体
２．０コウジ酸ナトリウム
０． ５アスコルビン酸パルミチン酸
エステル １．０ポリエチレング
リコール ５．０香料
適量染料 適量防腐剤
適量金属イオン封鎖剤
適量精製水 ２５．
５試験１
固形石けんの色白効果試験を行った。Example 1 (bar soap) Lanolin 2.5% by weight Olive oil 4.0 Kojic acid
1.0 Ascorbic acid 1.0
Ethylenediaminetetraacetic acid (appropriate amount) Fragrance
Appropriate amount Example 2 (Liquid whole body cleanser) Lauric acid 2.5% by weight Myristic acid 7.5 Palmitic acid
2.5 Oleic acid 2.
5 lauroyl diethanolamide 5.0% by weight propylene glycol 1O10 glycerin
5.0 Sugar 5.0 Caustic Potassium
3.6 Sodium kojate
0.5 fragrance, appropriate amount dye, appropriate amount preservative
Appropriate amount of sequestering agent
Appropriate amount of purified water 55.4 Example 3
(Cleansing foam) Stearic acid 1000% by weight Valmitic acid 10.0 Myrstic acid
12.0 Lauric acid 4.
0 Oleic alcohol 1.5 Lanolin derivative 1.0 Glycerin
18.0% by weight potassium hydroxide 6.
0 Kojic acid 1.0 Sodium ascorbate lO Fragrance 0. 5 preservatives
Appropriate amount of purified water
35.0 Example 4 (Cream facial soap) Lauroylgetanolamide 5,0 Glycerin monopalmitate ester 1.0 Lanolin derivative 2.0 Sodium kojate
0. 5 Ascorbic acid palmitate ester 1.0 Polyethylene glycol 5.0 Fragrance
Appropriate amount of dye Appropriate amount of preservative Appropriate amount of sequestering agent
Appropriate amount of purified water 25.
5 Test 1 A skin fairing effect test of bar soap was conducted.
８月、海岸で背部を３時間曝露した男子４０名を各１０
名ずつ、Ａ、Ｂ、Ｃ，Ｄの４群に分けた。In August, 40 men who exposed their backs on the beach for three hours were diagnosed with 10
The participants were divided into four groups: A, B, C, and D.
Ａ群
実施例１より、コウジ酸、アスコルビン酸を除いた固形
石けんで、１０週間、入浴の際、全身を洗浄した。Group A The whole body was washed with the same bar soap as in Example 1 except for kojic acid and ascorbic acid during bathing for 10 weeks.
Ｂ群
実施例１より、アスコルビン酸を除いた固形石けんで、
１０週間、入浴の際、全身を洗浄した。From Group B Example 1, bar soap excluding ascorbic acid,
For 10 weeks, the whole body was washed during bathing.
Ｃ群
実施例１よりコウジ酸を除いた固形石けんで、１０週間
、入浴の際、全身を洗浄した。Group C The whole body was washed with the same bar soap as in Example 1 except for kojic acid when taking a bath for 10 weeks.
０群
実施例１の固形石けんで、１０週間、入浴の際、全身を
洗浄した。Group 0 The whole body was washed with the bar soap of Example 1 during bathing for 10 weeks.
その後、表１に示す方法で官能評価試験を行った６
表１
表２
表２に示すように、本発明による。皮膚洗浄材は、Ａ、
Ｂ、Ｃ群、すべてと比較して評点が高い結果になってい
る。Ｂ、Ｃ群両方の効果を兼ね合わせており、特に肌の
はり、くすみに対しては顕著な効果を確認することがで
きた。Thereafter, a sensory evaluation test was conducted according to the method shown in Table 1. As shown in Table 2, according to the present invention. The skin cleansing material is A,
The score was higher than that of Groups B and C. It combines the effects of both groups B and C, and was particularly effective against firmness and dullness of the skin.
試験２ シミ・ソバカスの発生予防効果試験を行った。Exam 2 A test was conducted to prevent the appearance of age spots and freckles.
女性６０名を各１５名ずつＡ、Ｂ、Ｃ，Ｄの４群に分け
た。Sixty women were divided into four groups, A, B, C, and D, each with 15 participants.
Ａ群
実施例２より、コウジ酸ナトリウム、アスコルビン酸ス
テアリン酸エステルを除いた液状全身洗浄料と、実施例
３よりコウジ酸、アスコルビン酸ナトリウムを除いたク
レンジングフオームを４月から６ケ月間、毎日使用した
。Group A The liquid whole body cleanser from Example 2 excluding sodium kojic acid and ascorbic acid stearate and the cleansing foam from Example 3 excluding kojic acid and sodium ascorbate were used daily for 6 months starting from April. did.
Ｂ群
実施例２よりアスコルビン酸ステアリン酸エステルを除
いた液状洗浄料と、実施例３よりアスコルビン酸ナトリ
ウムを除いたクレンジングフオームを４月から６ケ月間
、毎日使用した。Group B A liquid cleanser from Example 2 except ascorbic acid stearate and a cleansing foam from Example 3 except sodium ascorbate were used daily for 6 months starting from April.
Ｃ群
実施例２よりコウジ酸ナトリウムを除いた液状洗浄料と
、実施例３よりコウジ酸を除いたクレンジングフオーム
を、４月より６ケ月間、毎日使用した。Group C: A liquid cleaning agent from Example 2 except for sodium kojic acid and a cleansing foam from Example 3 from which kojic acid was removed were used daily for 6 months starting from April.
Ｄ群
実施例２の液状全身洗浄料と実施例３のクレンジングフ
オームを４月より６ケ月間、毎日イ重用した。Group D The liquid whole body cleanser of Example 2 and the cleansing foam of Example 3 were used heavily every day for 6 months from April.
その後、表３に示す方法で、シミ・ソバカスの発生予防
効果の評価試験を行った。Thereafter, an evaluation test for the prevention effect of age spots and freckles was conducted using the method shown in Table 3.
表３
表４ ゛
表４に示すように、本発明による皮膚洗浄料はＡ、Ｂ、
Ｃ群、すべてと比較して、評点が高い結果となっている
。Ｂ、Ｃ群両方の効果を兼ね合わせており、シミ・ソバ
カスの発生予防効果に優れていることがわかった。Table 3 Table 4 ゛As shown in Table 4, the skin cleansing agent according to the present invention includes A, B,
Group C has a higher score than all other groups. It was found that it combines the effects of both groups B and C, and is excellent in preventing the appearance of age spots and freckles.
試験３
クリーム状洗顔石けんの色白効果
処方例１（クリーム）
ステアリン酸 １０００重量％ミツロウ
３．０セタノール
８．０スクワラン １０．０
モノステアリン酸グリセリン ３．０ポリオキシエチ
レンモノウラ
レート ３．０ラノリン誘導
体 ２．０プロピレングリコール
１０．０トリエタノールアミン １．０香料
０．５コウジ酸
０．５精製水 ４９
．０女性５０名を各１０名ずつＡ、Ｂ、Ｃ，Ｄ、Ｈの５
群に分けた。Test 3 Creamy facial soap with whitening effect Prescription example 1 (cream) Stearic acid 1000% by weight Beeswax 3.0 Cetanol
8.0 Squalane 10.0
Glyceryl monostearate 3.0 Polyoxyethylene monourarate 3.0 Lanolin derivative 2.0 Propylene glycol
10.0 Triethanolamine 1.0 Fragrance 0.5 Kojic acid
0.5 Purified water 49
．． 0 50 women, 10 each A, B, C, D, H
divided into groups.
Ａ群
３０日間、実施例４よりコウジ酸ナトリウム９アスコル
ビン酸パルミチン酸エステルを除いたクリーム状洗顔石
けんで洗顔後、処方例１よリコウジ酸を除いたクリーム
を顔面に塗布した。Group A was washed for 30 days with a creamy facial soap prepared from Example 4 except for sodium kojate and 9 ascorbyl palmitate, and then a cream prepared from Formulation Example 1 except for lykojic acid was applied to the face.
Ｂ群
３０日間、実施例４よりコウジ酸ナトリウム、アスコル
ビン酸パルミチン酸エステルを除いたクリーム状洗顔石
けんで洗顔後、処方例１によるクリームを顔面に塗布し
た。Group B: After washing their faces for 30 days with a creamy facial soap from Example 4 except for sodium kojate and ascorbyl palmitate, the cream according to Formulation Example 1 was applied to their faces.
Ｃ群
３０日間、実施例４よりアスコルビン酸パルミチン酸エ
ステルを除いたクリーム状洗顔石けんで洗顔後、処方例
１によるクリームを顔面に塗布した。Group C washed their faces for 30 days with the creamy facial soap of Example 4 except ascorbic acid palmitate, and then applied the cream according to Formulation Example 1 to their faces.
Ｄ群
３０日間、実施例４よりコウジ酸ナトリウムを除いたク
リーム状石けんで洗顔後、処方例１によるクリームを顔
面に塗布した。For 30 days in Group D, after washing their face with the creamy soap of Example 4 except for sodium kojate, the cream according to Formulation Example 1 was applied to the face.
Ｅ群
３０日間、実施例４によるクリーム状洗顔料で洗顔後、
処方例１によるクリームを顔面に塗布した。Group E: After washing the face with the creamy face wash according to Example 4 for 30 days,
The cream according to Formulation Example 1 was applied to the face.
その後、表１に示す方法で、官能評価試験を行った。Thereafter, a sensory evaluation test was conducted using the method shown in Table 1.
表５
表５に示すように、本発明による皮膚洗浄料はＡ、Ｂ、
Ｃ，Ｄ群すべてと比較して、評点が高い結果になってい
る。Ｃ，Ｄ群の効果を兼ね合わせ、さらにコウジ酸を含
有せしめたクリームと併用することにより、肌のはり、
くすみに対して相乗的に効果があることが確認でき、色
白効果を確認することができた。Table 5 As shown in Table 5, the skin cleanser according to the present invention includes A, B,
This results in higher scores than both groups C and D. Combining the effects of groups C and D, when used in combination with a cream containing kojic acid, the skin becomes firmer and firmer.
It was confirmed that the product had a synergistic effect on dullness, and a skin whitening effect was confirmed.
Claims (1)
スコルビン酸塩およびアスコルビン酸誘導体から選ばれ
る少なくとも１種を含有することを特徴とする皮膚洗浄
料。1. A skin cleanser containing kojic acid or kojic acid salts and at least one selected from ascorbic acid, ascorbate salts and ascorbic acid derivatives.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP22909788A JPH0278611A (en) | 1988-09-13 | 1988-09-13 | Skin cleaning agent |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP22909788A JPH0278611A (en) | 1988-09-13 | 1988-09-13 | Skin cleaning agent |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| JPH0278611A true JPH0278611A (en) | 1990-03-19 |
Family
ID=16886708
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP22909788A Pending JPH0278611A (en) | 1988-09-13 | 1988-09-13 | Skin cleaning agent |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPH0278611A (en) |
Cited By (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2050074A1 (en) * | 1991-08-23 | 1994-05-01 | Fischer Pharma Ltd | Compositions containing flavonoids |
| GB2282325A (en) * | 1993-09-30 | 1995-04-05 | Sansho Seiyaku Kk | Epidermal preparation comprising kojic acid and a surfactant |
| JPH0940543A (en) * | 1995-07-25 | 1997-02-10 | L'oreal Sa | Stable composition containing water-oversensitive make-up and/or dermatological activator |
| JPH0940545A (en) * | 1995-07-25 | 1997-02-10 | L'oreal Sa | Stable composition containing ascorbic acid |
| WO2001082884A1 (en) * | 2000-05-03 | 2001-11-08 | Unilever Plc | Detergent bar composition with benefit agents |
| JP2004352627A (en) * | 2003-05-28 | 2004-12-16 | Kuraray Co Ltd | External preparation for skin |
| US8158570B2 (en) | 2005-10-07 | 2012-04-17 | The Sun Products Corporation | Stain removal |
| JP2012211105A (en) * | 2011-03-31 | 2012-11-01 | Kose Corp | Oily solid composition, method for producing the same, and oily solid product |
-
1988
- 1988-09-13 JP JP22909788A patent/JPH0278611A/en active Pending
Cited By (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2050074A1 (en) * | 1991-08-23 | 1994-05-01 | Fischer Pharma Ltd | Compositions containing flavonoids |
| GB2282325A (en) * | 1993-09-30 | 1995-04-05 | Sansho Seiyaku Kk | Epidermal preparation comprising kojic acid and a surfactant |
| GB2282325B (en) * | 1993-09-30 | 1997-12-10 | Sansho Seiyaku Kk | Preparation for epidermis |
| JPH0940543A (en) * | 1995-07-25 | 1997-02-10 | L'oreal Sa | Stable composition containing water-oversensitive make-up and/or dermatological activator |
| JPH0940545A (en) * | 1995-07-25 | 1997-02-10 | L'oreal Sa | Stable composition containing ascorbic acid |
| WO2001082884A1 (en) * | 2000-05-03 | 2001-11-08 | Unilever Plc | Detergent bar composition with benefit agents |
| JP2004352627A (en) * | 2003-05-28 | 2004-12-16 | Kuraray Co Ltd | External preparation for skin |
| US8158570B2 (en) | 2005-10-07 | 2012-04-17 | The Sun Products Corporation | Stain removal |
| JP2012211105A (en) * | 2011-03-31 | 2012-11-01 | Kose Corp | Oily solid composition, method for producing the same, and oily solid product |
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