JPH0543428A - Cosmetic - Google Patents

Abstract

PURPOSE:To provide a cosmetic having high lipase activity-inhibitory effect, thus capable of thoroughly resolving troubles due to excessive sebum secretion, comprising a combination of specific surfactants. CONSTITUTION:The objective cosmetic containing (A) 0.01-10 (pref. 0.1-5) wt.% of a glucose fatty acid ester of formula I(R1CO-is 2-22C fatty acid residue; R2 is H or 1-4C alkyl), e.g. 6-0-octanoylglucose or ethyl-6-0-lauroylglucoside and (B) 0.01-10 (pref. 0.1-5) wt.% of a polyoxyalkylene compound of formula II. (R3 is H or 1-8C alkyl; m is 5-100; n is 1-100). High lipase activity-inhibitory effect developed by combination of both the components A and B will prevent hair odor and/or scalp odor.

Description

Detailed Description of the Invention

[0001]

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to a cosmetic having a high lipase activity inhibitory effect and preventing hair odor and scalp odor.

[0002]

2. Description of the Related Art Sebum secreted from the sebaceous gland has the effect of making skin fluff soft and smooth, and imparting a moisturizing effect to skin fluff. In addition, this sebum prevents the invasion of various stimulants from the outside of the body into the skin and also has an action of supplying an appropriate amount of oil to the hair in the scalp. However, if sebum that has such a significant effect is secreted too much, it may cause acne, or cause oil and oil on the skin and hair to cause pathogenic bacteria to propagate, causing troubles on skin and skin. It produces an odor. Conventionally, in order to eliminate the trouble caused by the excessive secretion of sebum, the skin is washed with soap, vitamin A and antibiotics,
Toner lotion containing animal and plant extracts (JP-A-63-179812)
No. 63-215612, No. 63-174915.
No. 63-77808, No. 63-1049, No. 6
No. 2-148427) has been proposed. Further, it has been proposed to use a lotion containing lipopolysaccharide that removes sebum (JP-A-1-63507). However, these methods cannot prevent the generation of hair odor and scalp odor, and still do not give satisfactory results. The occurrence of hair odor and scalp odor is caused by lower fatty acids such as capric acid and caproic acid produced when sebum is decomposed by lipase, and unless the lipase activity that decomposes sebum is inhibited, Occurrence cannot be prevented. For example, even if the scalp lipid is removed by washing with shampoo, 80% of the scalp lipid is recovered 6 hours after the washing (Nippon Kaihatsu, 87 (11),
671-688, 1971). Therefore, even with shampoo, the scalp and hair immediately become sticky or odor is generated. As described above, heretofore, a technique for fundamentally improving the trouble due to the excessive secretion of sebum as described above has not been proposed yet.

[0003]

SUMMARY OF THE INVENTION It is an object of the present invention to provide a cosmetic composition capable of fundamentally solving the trouble caused by excessive secretion of sebum.

[0004]

As a result of intensive studies to solve the above-mentioned problems, the inventors of the present invention can solve the above-mentioned problems by using a combination of two specific types of surfactants. The present invention has been completed and the present invention has been completed. That is, according to the present invention, the general formula

[0005]

[Chemical 1]

(Wherein R ₁ CO- represents a fatty acid residue having ₂ to 22 carbon atoms, and R ₂ represents hydrogen or an alkyl group having 1 to 4 carbon atoms). 10 wt% and the general formula R ₃ O (C ₂ H ₄ O) m (C ₃ H ₆ O) nH (2) (wherein R ₃ represents hydrogen or an alkyl group having 1 to 8 carbon atoms, m Is an integer of 5 to 100 and n is an integer of 1 to 100).
A cosmetic containing 1 to 10% by weight is provided.

As the glucose fatty acid ester (R = H in the general formula (1)) used as one component of the surfactant in the present invention, for example, 6-o-
Octanoyl glucose, 6-o-decanoyl glucose, 6-o-lauroyl glucose, 6-o-myristoyl glucose, 6-o-palmitoyl glucose, 6
Examples thereof include -o-oleyl glucose and 6-o-linoleoyl glucose. In addition, alkyl glucoside fatty acid ester (in the general formula (1), R = C 1
~ 4 alkyl group), methyl-6-o-octanoylglucoside, ethyl-6-o-octanoylglucoside, ethyl-6-o-lauroylglucoside, butyl-6-o-octanoylglucoside, ethyl- 6-o
-Palmitoyl glucoside, ethyl-6-o-oleyl glucoside, etc. are mentioned. These glucose fatty acid esters are used alone or in combination of two or more. The blending amount is 0.01 to 10% by weight, preferably 0.1.
~ 5% by weight. If the amount of glucose fatty acid ester is less than the above range, the effect of addition is insufficient, and if it exceeds the above range, the stability of the product is deteriorated and the product becomes sticky.

In the polyoxyalkylene compound represented by the general formula (2) used as the other surfactant component in the present invention, the number of moles m of ethylene oxide added is 5 to
100, preferably 10 to 60, and the number of moles n of propylene oxide added is 1 to 100, preferably 5 to 30.
Is. The sum of m and n (m + n) is 10 to 200, preferably 15 to 90, and the ratio of m and n (m / n) is 1 /
It is 6 to 6/1, preferably 1/2 to 6/1. Among the polyoxyalkylene compounds represented by the general formula (2), those of the pluronic type in which R ₃ is hydrogen are known to have an oil removing effect (SPC).
November, 1985, P. Alexande
r, P623-625, 628). However, such a polyoxyalkylene compound shows only a temporary effect by itself and does not have a long-lasting effect. Therefore, such a thing cannot prevent hair odor and scalp odor. On the other hand, when a glucose fatty acid ester is combined with this polyoxyalkylene compound, a high lipase activity inhibitory effect is produced, hair odor and scalp odor can be prevented, and troubles due to excess sebum can be fundamentally solved. The compounding amount of the polyoxyalkylene compound is 0.01 to 10
%, Preferably 0.1 to 5% by weight. The polyoxyalkylene compounds can be used alone or in combination. In the present invention, it is preferable to use a polyoxyalkylene compound which is liquid at room temperature. In the present invention, conventional auxiliary components used in cosmetics can be blended. Examples of such auxiliary components include cationic, anionic, nonionic or amphoteric surfactants and polymers, vitamins, amino acids, higher alcohols, hydrocarbons, ester oils, colorants, and fragrances.

[0009]

EFFECT OF THE INVENTION The cosmetic composition of the present invention has a high lipase activity inhibitory effect which is exhibited by the combination of two kinds of surfactants contained therein, and fundamentally solves the trouble caused by excessive secretion of sebum. be able to. The cosmetics of the present invention include shampoo, rinse, hair foam, face wash,
Includes lotion, face wash, and the like.

[0010]

EXAMPLES Next, the present invention will be described in more detail by way of examples.

Example 1 A solution having the component composition (% by weight) shown in Table 1 was prepared, and its lipase activity inhibitory effect was evaluated as follows. (Lipase activity inhibitory effect test) The lipase activity inhibitory effect was measured by Candida cylin manufactured by Seikagaku Corporation.
Dracea origin lipase [10000 U / mg protein]
Was used, and the measurement was performed with a lipase kit S manufactured by Dainippon Pharmaceutical Co., Ltd. (1) The color developing solution [5,5′-dithiobis (2-
(Nitrobenzoic acid), 98 μg / ml] 1 ml, lipase [10 U / ml] 30 μl, specimen 5 adjusted to a predetermined concentration
After adding 0 μl and mixing, 20 μl of phenylmethylsulfonyl fluoride [3.48 mg / ml] was added.
After mixing, after preheating at 30 ± 1 ° C. for 5 minutes, 100 μl of the substrate solution [dimercaprol tributyrate 6.69 mg / ml] was added, and further incubated at 30 ± 1 ° C. for 30 minutes,
2 ml of the reaction stop solution [sodium dodecyl sulfate solution] was added, and the absorbance A at 412 nm was measured for purified water within 1 hour. (2) At the same time, as a blind test, the absorbance B was measured in the same manner as above except that the substrate solution was added after the reaction stop solution was added. (3) For the control of the lipase activity, 50 μl of purified water was added instead of the sample, and the absorbances SA and SB were measured in the same manner as above. From the absorbance obtained as described above, the lipase activity inhibition rate R (%) is calculated by the following formula. The specific contents of the activators (1) and (2) shown in Table 1 are as follows. (1) Activator (1) Methyl-6-o-octanoylglucoside (2) Activator (2) HO (C ₂ H ₄ O) ₂₀ (C ₃ H ₆ O) ₃₀ H (3) Activator (3 ) C ₈ H ₁₆ O (C ₂ H ₄ O) ₅₀ (C ₃ H ₆ O) ₂₀ H

[0012]

[Table 1]

As can be seen from the results shown in Table 1, the compositions of the present invention (Experiment Nos. 4, 5, 6) show a high lipase activity inhibition rate R. Next, α-olefin sulfonate: 10% by weight, polyoxyethylene (added mole number =
5) Lauryl ether sulfate: 10% by weight, stearyltrimethylammonium chloride: 1% by weight, coconut oil fatty acid diethanolamide: 2% by weight, sodium sulfate: 2% by weight, fragrance: 0.5% by weight, pigment: trace amount, table A shampoo consisting of the active agent shown in No. 2 in the ratio (% by weight) shown in Table 2 and water: balance was prepared, and the hair was washed with this shampoo to remove the hair odor or scalp odor one and two days after washing. It investigated as follows. The results are shown in Table 2. (Evaluation method of hair odor or scalp odor) Panel 10 people (21-
35 years old man) is shampooed,
Hair odor and scalp odor one day and two days after the treatment were evaluated according to the following criteria. ◎: 8 people or more do not smell ○: 6 people or more do not smell △: 4 people or less do not smell ×: 2 people or less do not smell

[0014]

[Table 2]

The specific contents of Activator A and Activator B shown in Table 2 are as follows. (Activator A) Ethyl -6-o-lauroyl glucoside (activator _{B) C 4 H 9 O (} C 2 H 4 O) 30 (C 3 H 6 O) 10 H

Next, the following various cosmetics were prepared,
When the hair odor and the scalp odor one day after the treatment were examined in the same manner as in Example 1, all showed good results. In addition, POE shown below shows an ethylene oxide component, and POP shows a propylene oxide component.

Example 2 (rinsing agent) Alkyltrimethylammonium chloride 1 (wt%) cetostallyl alcohol 3 propylene glycol monostearate 1 POE (20) hydrogenated castor oil triisostearate 0.7 POE (15) glyceryl monoisolate Stearate 0.5 Ethyl-6-o-oleoyl glucoside 5 POE (30) POP (5) Hexyl ether 2 Highly polymerized silicone (MW = 1 million) 2 Glycerin 5 Perfume 0.2 Dye Trace amount Purified water balance

Example 3 (Hair Foaming Agent) Stearyl trimethyl ammonium chloride 0.3 (wt%) Cationized cellulose 0.7 Polymethacrylic acid ester (trade name: Yukafomer 204W) 10 (wt%) Coconut oil fatty acid diethanolamide 0 .5 POE (30) stearyl ale 1 ethanol 15 methylparaben 0.1 butyl-6-o-octanoyl glucoside 0.05 POE (50) POP (30) glycol ether 0.1 perfume 0.2 purified water balance the above composition As a stock solution and propellant (LPG) as a stock solution / LP
A hair foam agent is prepared by filling so that G = 93/7.

Example 4 (Facial cleanser) Potash soap 33 (% by weight) Myristic acid 7 Beeswax 2 Polyethylene glycol 20 Potassium β-glycyrrhetinate 0.2 POE (40) POP (10) glycol 0.5 Ethyl-6-o -Lauroyl glucoside 1.5 Glycerin 9 Propylene glycol 3 Perfume 0.3 Purified water balance

Example 5 (Facial cleansing foam) Sodium N-cocoyl glutamate 10 (wt%) myristic acid 1 cetostearyl alcohol 2 POE (20) sorbitan monopalmitate 1 (wt%) glycerin 3 POE (40) POP (20) ) Glycol 5 Methyl-6-o-octanoyl glucoside 8 Perfume 0.3 Purified water balance The above composition was used as a stock solution, and a propellant (LPG) was filled so that the stock solution / propellant (LPG) = 95/5. Make a facial cleansing foam.

Example 6 (Lotion) POE-modified silicone 0.5 (wt%) Aloe extract 1.0 Cucumber extract 0.5 Sodium pyrrolidonecarboxylate 0.3 Sorbit 1.5 POE (10) POP (20) 2-Ethylhexyl ether 0.05 Methyl-6-o-oleoyl glucoside 0.1 POE (60) hydrogenated castor oil 0.7 Methylparaben 0.1 Ethanol 10 Citric acid 0.1 Perfume 0.2 Purified water balance

Claims (1)

[Claims] 1. A general formula: (In the formula, R ₁ CO- represents a fatty acid residue having ₂ to 22 carbon atoms, and R ₂ represents hydrogen or an alkyl group having 1 to 4 carbon atoms)
Glucose fatty acid ester represented by 0.01 to 10
And weight%, of the general formula _{R 3 O (C 2 H 4} O) m (C 3 H 6 O) nH ( wherein, R ₃ represents an alkyl group having 1 to 8 carbon hydrogen or carbon, m is 5-100 And n is an integer of 1 to 100) polyoxyalkylene compound 0.0
A cosmetic containing 1 to 10% by weight.