JP2001199873A - Composition for external use - Google Patents

Abstract

PROBLEM TO BE SOLVED: To obtain a composition for external use capable of solving the problem that, although a melanin suppressing composition for external use in a conventional beautifying cosmetic or the like is compounded with a melanin formation suppressing component, the actual processes of the formation and distribution of melanin in the skin are very complicated, and even a cosmetic prepared by singly compounding a component which can effectively inhibit or suppress one mechanism of the formation of melanin cannot exhibit practical beautifying effect such as the discoloration or disappearance of pigment deposition effectively sufficiently in a short time. SOLUTION: A cosmetic prepared by compounding a component having melanin formation suppressing activity, a component having inflammatory effect and a component having keratin removal stimulating activity, together. This cosmetic can reduce or remove pigment deposition quickly and effectively.

Description

DETAILED DESCRIPTION OF THE INVENTION

[0001]

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to the external use of cosmetics, medicated cosmetics and the like, mainly for skin whitening, characterized by simultaneously combining a melanin production inhibitor, an anti-inflammatory agent and a keratin exfoliation promoter. Compositions and methods for whitening.

[0002]

2. Description of the Related Art Conventionally, whitening cosmetics have been solely blended with components that suppress the production of melanin.
However, the production and distribution process of melanin in the actual skin is very complicated, and even if a cosmetic contains only a component that can effectively inhibit or suppress one mechanism of melanin production, pigmentation may occur. There was still no satisfactory way to effectively exert the real whitening effect of fading or disappearing in a short period of time.

[0003]

SUMMARY OF THE INVENTION An object of the present invention is to provide a skin whitening agent capable of effectively fading or eliminating melanin pigmentation in a short period of time, which was impossible with conventional whitening preparations such as whitening cosmetics. And a whitening method using the same.

The present inventors have conducted intensive studies on the reduction or elimination of pigmentation. As a result, surprisingly, a component having an inhibitory action on melanin production, a component having an anti-inflammatory action and a component having an action on promoting exfoliation of keratin were simultaneously obtained. The present inventors have found that the formulated cosmetics can discolor or eliminate pigmentation as quickly and effectively as possible, and have completed the present invention.

[0005]

SUMMARY OF THE INVENTION The present invention provides a cosmetic composition containing a component having an inhibitory action on melanin production, a component having an anti-inflammatory action and a component having an action on promoting exfoliation at the same time. By reducing or eliminating pigmentation, the effect expected of whitening cosmetics can be fully exhibited.

The following mechanism is considered to make the composition for external use of the present invention more effective than conventional whitening agents. That is, the production of inflammatory signaling substances, which are greatly involved in the initial stage of the synthesis of melanin, the causative substance of color cord deposition, is suppressed by an anti-inflammatory agent, and the action of pigment cells, which are melanin-synthesizing cells, is suppressed by melanin production. In addition to controlling by the agent, the melanin already distributed from the pigment cells to the keratinocytes promotes exfoliation of the keratin itself from the skin with the keratin exfoliating agent, which results in the formation of pigmentation that is more prominent than conventional whitening agents. It has a reducing or eliminating effect.

[0007]

BEST MODE FOR CARRYING OUT THE INVENTION The cosmetic of the present invention is characterized in that a component having an inhibitory action on melanin production, a component having an anti-inflammatory action and a component having an action on promoting exfoliation of keratin are simultaneously added.

The melanogenesis inhibitors of the present invention include, for example, kojic acid, arbutin, vitamin C and derivatives thereof such as ascorbic acid-2-glucoside, magnesium or sodium ascorbic acid-2-phosphate, ascorbic acid palmitate or stearate, Ellagic acid, soybean sprouts, resorcinol derivatives, placenta extract, mulberry extract, rice haiga extract, chamomile extract, rice bran extract, etc. Vitamin C and its derivatives, rice bran extract.

[0009] The anti-inflammatory agent of the present invention includes a glycyrrhizic acid derivative, sodium or potassium glycyrrhizinate, licorice extract, indomethacin, aspirin, allantoin, licorice extract, peony extract, gentian extract, assembly extract, carrot extract and the like. It may be a simple substance or a compound selected from the components described above, and preferably a liquorice extract, a peony extract, and a carrot extract.

[0010] The exfoliating agent of the present invention includes glycolic acid,
Lactic acid, citric acid, succinic acid, tartaric acid, malic acid, α-hydroxy acids and salts thereof, may be a simple substance or a compound selected from components having a known exfoliating action such as fermented lactic acid bacteria, and preferably Lactic acid and a lactic acid-containing bacterial fermentation solution are preferred.

In the present invention, the addition concentration of the three components of the melanin production-inhibiting agent, the anti-inflammatory agent and the exfoliating agent is preferably in the range of 0.1 to 50.0% by weight in the external composition. Is good enough.

In order to obtain a good whitening effect such as prevention of spots and freckles due to sunburn with the composition for external use of the present invention, the external preparation of the present invention adjusted in the above range should be prepared in the following manner.
It is desirable to apply to the skin at a concentration of 0.01 to 1 ml / cm 2 per day per day.

The external preparation of the present invention includes ointments, creams, lotions, lotions, emulsions, essences, lip balms, gels, masks, packs, foundations,
It can be incorporated into various dosage forms such as lipstick, soap, body shampoo, shampoo, rinse, hair restorer, hair styling agent, hair dye, bath agent, toothpaste, mouthwash, adhesive plaster, patch and the like.

The external preparation of the present invention may contain, if necessary, a surfactant (cation, anion, nonionic surfactant, etc.),
Moisturizer (glycerin, polyethylene glycol, 1,3
-Natural lipids such as butylene glycol, sodium lactate, pullulan, sodium alginate, sodium pyrrolidone carboxylate, chitosan, thickeners (xanthan gum, quince seed extract, tragacanth gum, pullulan, sodium alginate,) squalane, oils and fats ( DH
A, EPA, linoleic acid, avocado oil, olive oil, sesame oil, almond oil, etc., preservatives (methyl parahydroxybenzoate, ethyl paraoxybenzoate, propyl parahydroxybenzoate, sodium dehydroacetate, chlorobutanol, sorbic acid), ultraviolet absorption Agents, anti-inflammatory agents such as glycyrrhizic acid, analgesics, whitening agents (vitamin C derivatives, arbutin, ellagic acid, kojic acid, placenta extract, chamomile extract, soybeans, etc.), chelating agents (disodium edetate), pigments, anti-inflammatory agents Oxidizing agents (vitamin A, E derivatives, polyphenols, etc.), pH adjusters (organic acids such as citric acid, phosphoric acid, amino acids, etc.), medicinal ingredients (α-hydroxy acid, DNA, chitin, chitosan, crude drugs, vitamins,
Glycosphingolipids) and fragrances can be appropriately compounded in a range of 0.0001 to 90% by weight within a range that achieves the object of the present invention.

[0015] Bath agents include sodium sulfate, sodium hydrogen carbonate, borax, pigments (Yellow 202, anthocyanin-based natural pigments, turmeric pigments, red koji pigments, etc.) and humectants (glycerin, polyethylene glycol, 1,3-butylene). Glycol, sodium lactate, pullulan, sodium alginate, sodium pyrrolidone carboxylate, chitosan, etc.), an active ingredient and a fragrance in an amount of 0.0001 to 90% by weight within a range that achieves the object of the present invention. , Granule type and liquid type bath preparations can be produced.

Examples of the external preparation of the present invention and test examples of its effects are shown below.

Embodiment 1

Embodiment 2

Embodiment 3

Embodiment 4

[0017]

[Comparative Example] (1) Comparative lotion 1 Purified water was used in place of the rice bran extract, licorice extract, and fermented lactic acid bacterium of Formulation Example (1), and the whole amount was adjusted. . (1) Comparative lotion 2 Prepared according to Formulation Example (1) except that purified water was mixed in place of the rice bran extract and licorice extract of Formulation Example (1) to adjust the total amount. (1) Comparative lotion 3 Purified water was used instead of the rice bran extract and the lactic acid bacteria fermented solution of Formulation Example (1), and the whole amount was adjusted. (1) Comparative lotion 4 Purified water was used instead of the liquorice extract and lactic acid bacteria fermented solution of Formulation Example (1), and the whole amount was adjusted. (1) Comparative lotion 5 Purified water was used in place of the rice bran extract in Formulation Example (1), and the whole amount was adjusted, except that it was prepared according to Formulation Example (1). (1) Comparative lotion 6 Prepared according to Formulation Example (1) except that purified water was mixed instead of Licorice extract of Formulation Example (1) to adjust the total amount. (1) Comparative lotion 7 Purified water was used instead of the lactic acid bacteria fermented solution of Formulation Example (1), and the whole amount was adjusted, except that it was prepared according to Formulation Example (1).

Pigmentation lightening evaluation test Each of the cosmetics prepared in the prescription examples and the comparative prescription examples was divided into 8 groups of 20 healthy volunteers each having 160 pigmented individuals. Each of Comparative Lotions (1) to (7) and the lotion of the present invention of Formulation Example (1) was administered twice daily in the morning and evening to eight groups.
The pigment was used in the pigmented portion, and the degree of remission of pigmentation was evaluated 2 weeks and 4 weeks after the start of use, based on the criteria shown in Table 1. The final observation period was 8 weeks after the start of use. The results are shown in Table 2, and the formulation example (1) of the present invention
It was found that the lotion use group showed a quicker tendency for melanin pigmentation on the skin to appear faster than any of the use groups of the comparative prescription examples, and the effect at the final observation was remarkable.

Continued on the front page (51) Int.Cl. ⁷ Identification symbol FI Theme coat II (reference) A61K 7/00 A61K 7/00 H

Claims (4)

[Claims] A composition for external use characterized by simultaneously mixing three components of a melanin production inhibitor, an anti-inflammatory agent and a keratin exfoliating agent. 2. The melanin production-inhibiting agent is a simple substance or a compound selected from kojic acid, arbutin, vitamin C and its derivatives, ellagic acid, resorcinol derivatives, placenta extract, mulberry extract, licorice extract and rice bran extract. Inflammatory agents are glycyrrhizic acid derivatives, indomethacin, aspirin, allantoin, licorice extract,
Peony extract, gentian extract, assembly extract, or a carrot extract is a simple substance or a complex, and the exfoliating agent is selected from glycolic acid, lactic acid, citric acid, succinic acid, tartaric acid, and salts thereof, and fermented lactic acid bacteria. The composition for external use according to claim 1, which is a simple substance or a composite. 3. The composition according to claim 1, wherein the composition for external use is for preventing skin spots or freckles due to sunburn, suppressing the production of melanin in the skin, or fading or eliminating the melanin pigment to whiten the skin. 4. A whitening method comprising applying three components comprising a melanin production-inhibiting agent, an anti-inflammatory agent and an exfoliating agent to the skin simultaneously or within 24 hours.