JP2000044459A - Skin preparation for external use - Google Patents

Abstract

PROBLEM TO BE SOLVED: To provide a highly safe skin preparation for external use, effective for the prevention and symptom improvement of skin pigmentation, especially stains and freckles. SOLUTION: This skin preparation for external use contains the hydrolysate of a rice bran extract and one or more kinds of agents selected from kojic acid and its derivatives, arbutin, ascorbic acid and its derivatives, ellagic acid, resorcinol derivatives, a placenta extract, a white mulberry root bark extract and a Saxifraga stolonifera extract.

Description

DETAILED DESCRIPTION OF THE INVENTION

[0001]

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to an external preparation for skin which has an excellent whitening effect and is effective for preventing skin pigmentation such as spots and freckles and improving symptoms.

[0002]

2. Description of the Related Art Various whitening agents such as kojic acid, ascorbic acid derivatives and hydroquinone derivatives have been conventionally proposed for the purpose of preventing pigmentation caused by sunburn or aging, especially spots and freckles, and improving symptoms. An external preparation for skin containing is marketed. However,
Those conventional whitening agents, in addition to the whitening effect itself is not always satisfactory, when the amount is increased to maximize the whitening effect, may cause skin irritation problems, There are still many points to be improved in terms of practicality.

[0003]

DISCLOSURE OF THE INVENTION In view of the problems of the prior art, the present inventors have conducted intensive studies to provide a skin external preparation having an excellent whitening effect and a high safety. When a hydrolyzate of rice bran extract is used in combination with an existing whitening agent such as arbutin and the like, a synergistic action of the combination significantly enhances the whitening effect, thereby further improving the skin whitening and skin whitening effect. Has been found to be able to provide a skin external preparation with little skin irritation and excellent safety because it can be expected to have an excellent whitening effect even at a low blending amount as a result of improving the whitening effect. The present invention has been completed.

[0004]

That is, the present invention relates to a hydrolyzate of rice bran extract and kojic acid and its derivatives, arbutin, ascorbic acid and its derivatives, ellagic acid, resorcinol derivatives, placental exudates, soybean extract and It is an external preparation for skin prepared by combining one or more whitening agents selected from Saxifraga extract.

Hereinafter, the present invention will be described in detail. The hydrolyzate of rice bran extract used in the present invention is obtained by hydrolyzing an extract obtained by extracting rice bran with a solvent such as water or alcohol with an acid, an alkali, an enzyme or the like.

Solvents used for extraction include water, alcohols such as methanol and ethanol, polyhydric alcohols such as ethylene glycol, propylene glycol, 1,3-butylene glycol and glycerin, ethyl acetate, and the like.
There are esters such as butyl acetate and methyl propionate, ketones such as acetone and methyl ethyl ketone, ethers such as ethyl ether and isopropyl ether, and hydrocarbon solvents such as hexane, toluene and chloroform. Or after adjusting the pH with an acid or an alkali. Among them, in the present invention, it is preferable to use water or a mixed solution of water and alcohols or water and polyhydric alcohols, and particularly, to use them with an alkali such as sodium hydroxide, potassium hydroxide, and sodium carbonate. PH 7.5 to 14, especially p
Most preferably, an alkaline aqueous medium adjusted to the range of H9 to 12 is used.

The extraction temperature and time vary depending on the solvent used and the like, but are generally about 4 hours to 40 ° C. for about 6 hours to 7 days. When the above-mentioned alkaline aqueous medium is used, 12 hours at 4 ° C. to 30 ° C. ~ 36 hours is preferred.

[0008] The hydrolysis of the rice bran extract obtained here
The reaction is carried out using an acid, an alkali or an enzyme. Above all, decomposition by an enzyme is preferred from the viewpoint of uniformity of the quality of the product, ease of process control, and the like. In the case of acid hydrolysis,
As the acid, hydrochloric acid, sulfuric acid, or the like is used, and the pH of the extract is usually adjusted to 5 or less, particularly 4 or less.
Heating may be performed for 6 hours. In the case of alkaline hydrolysis, the pH of the extract is generally adjusted to 9 to 13 using caustic soda, caustic potash, sodium carbonate, and the like, and heat treatment is generally performed at 60 to 90 ° C for 1 to 6 hours. is there.

In the case of enzymatic hydrolysis, the enzymes used include actinases, pepsins such as pepsin, and the like.
Trypsin such as trypsin, papain, papains such as chymopapain, glycylglycine peptidase,
Examples include peptidases such as carboxypeptidase and aminopeptidase, and bromelain, and these are usually used in combination of two or more. When enzymes are used in combination, the combination of actinase and pepsin or trypsin is most preferred.

[0010] In the hydrolysis treatment with these enzymes, the enzyme is added in an amount of 0.0005 to 0.5 to 100 parts by weight of the rice bran extract.
The reaction is carried out by using 05 parts by weight, preferably 0.001 to 0.005 parts by weight, and reacting under conditions near the optimum pH and the optimum temperature of the enzyme used for 1 to 24 hours.

The obtained rice bran extract hydrolyzate solution is generally adjusted to pH 4 to 8 and then used as it is or after being further adjusted to an appropriate concentration by concentration. Powdered and used according to a conventional method such as a spray drying method and a freeze drying method.

In the present invention, among the whitening agents used in combination with the above-mentioned hydrolyzate of rice bran extract, the kojic acid derivatives include, for example, kojic acid monobutyrate, kojic acid monocaprate, kojic acid monopalmitate, kojic acid dibutyrate Examples of kojic acid esters such as kojic acid ethers and ascorbic acid derivatives include ascorbic acid ester salts (salts such as L-ascorbic acid-2-phosphate ester salt and L-ascorbic acid-2-sulfate ester salt). Is a sodium salt, a magnesium salt, etc.), L-
Ascorbic acids such as ascorbic acid-2-glucoside (2-O-α-D-glucopyranosyl-L-ascorbic acid) and L-ascorbic acid-5-glucoside (5-O-α-D-glucopyranosyl-L-ascorbic acid) Acid sugar derivatives and resorcinol derivatives include 4-n-butyl resorcinol, 4-isoamyl resorcinol and the like. In addition, as the placenta extract, those of cosmetic compounding grades listed in the official cosmetics certificate can be suitably used.

In the present invention, among the whitening agents used in combination with the rice bran extract hydrolyzate, particularly, kojic acid,
Arbutin, L-ascorbic acid-2-phosphate magnesium salt and L-ascorbic acid-2-glucoside are preferred from the viewpoint of the obtained whitening effect.

The blending ratio of the rice bran extract hydrolyzate and the whitening agent is generally in the range of 20: 1 to 1:20, preferably 10: 1 to 1:10, particularly preferably 10: 1 to 1:10 in terms of solids weight ratio. 5: 1 to 1: 5. The compounding ratio of the whitening agent to the rice bran extract is more than 1:20 or 2
When the ratio is less than 0: 1, the synergistic effect is hardly exhibited, and the merits of the combination are reduced.

The amount of the hydrolyzate of rice bran extract and the whitening agent in the external preparation for skin of the present invention is generally within the range of the above-mentioned mixing ratio. 0015 to 0.5% by weight, preferably 0.005 to
0.15% by weight, and in the case of a whitening agent it is generally in the range of 0.1 to 10% by weight, preferably 0.5 to 5% by weight. When the amount is less than the above range, it is difficult to obtain a sufficient whitening / skinning effect. On the other hand, even with the above range, not only a further improvement in the cosmetic effect cannot be expected, but also skin irritation based on a whitening agent, Alternatively, problems arise in terms of cost and the like, and both are not preferable.

The external preparation for skin of the present invention can be used as any of cosmetics, quasi-drugs and medicaments, and its dosage form is, for example, cream, emulsion, lotion, ointment,
Appropriate materials such as packs and cataplasms can be adopted according to the intended use and the application object.

The external preparation for skin of the present invention includes, in addition to the essential components, hydrolyzate of rice bran extract and whitening agent, oily components, surfactants, moisturizers, thickeners, and preservatives which are usually used in external preparations for skin. A bactericide, a powder component, an ultraviolet absorber, a dye, a fragrance and the like are appropriately compounded as required.

Here, as the oily component, olive oil,
Oils such as jojoba oil, castor oil, soybean oil, coconut oil, palm oil, cacao oil, mink oil, turtle oil; waxes such as beeswax, carnauba wax, lanolin; liquid paraffin;
Hydrocarbons such as petrolatum, paraffin wax and squalane; fatty acids such as myristic acid, palmitic acid, stearic acid, oleic acid and isostearic acid; higher alcohols such as lauryl alcohol and cetanol stearyl alcohol; isopropyl myristate and isopropyl palmitate And synthetic esters such as butyl oleate.

Examples of the surfactant include polyoxyethylene alkyl ether, polyoxyethylene fatty acid ester, polyoxyethylene sorbitan fatty acid ester, glycerin fatty acid ester, polyglycerin fatty acid ester, polyoxyethylene glycerin fatty acid ester, and polyoxyethylene hydrogenated castor oil. Nonionic surfactants such as fatty acid esters of polyoxyethylene sorbitol, fatty acid salts, alkyl sulfates, alkylbenzene sulfonates, polyoxyethylene alkyl ether sulfates, polyoxyethylene fatty amine sulfates, polyoxyethylene alkyl phenyl ether sulfates Polyoxyethylene alkyl ether phosphates, α-sulfonated fatty acid alkyl ester salts, polyoxyethylene alkyl phenyl ether phosphates, etc. On surfactant; quaternary ammonium salts, primary to tertiary fatty amine salts, trialkyl benzyl ammonium salts, alkyl pyridinium salts, 2
Cationic surfactants such as -alkyl-1-alkyl-1-hydroxyethylimidazolinium salts, N, N-dialkylmorphonium salts and polyethylenepolyamine fatty acid amide salts; N, N-dimethyl-N-alkyl-N
-Carboxymethylammoniobetaine, N, N, N-
Zwitterionic surfactants such as trialkyl-N-alkyleneammoniocarboxybetaine and N-acylamidopropyl-N'N'-dimethyl-N'-β-hydroxypropylammoniosulfobetaine are exemplified.

Examples of humectants include glycerin, propylene glycol, dipropylene glycol, 1,3-
Butylene glycol, polyethylene glycol, sorbitol, xylitol, pyrrolidone carboxylate and the like.

Examples of the thickener include tragacanth gum,
Examples include sodium alginate, pectin, sodium carboxymethylcellulose, polyvinyl alcohol, carboxyvinyl polymer, polyacrylic acid and its derivatives, gelatin, polyvinylpyrrolidone, veegum, methylpolysiloxane, and dextran.

Examples of the antiseptic disinfectant include urea, methyl parahydroxybenzoate, ethyl paraoxybenzoate, propyl paraoxybenzoate, butyl paraoxybenzoate,
Phenoxyethanol, dichlorophen, hexachlorophen, chlorhexidine hydrochloride, benzalkonium chloride, salicylic acid, ethanol and the like.

Examples of the powder component include titanium oxide, talc, kaolin, bentonite, zinc oxide, magnesium carbonate, magnesium oxide, zirconium oxide, barium sulfate, silicic anhydride, mica, nylon powder, silk powder and the like.

Examples of the ultraviolet absorbent include ethyl paraaminobenzoate, ethylhexyl paradimethylaminobenzoate, amyl salicylate, ethylhexyl paramethoxycinnamate, octyl cinnamate, 2,4-dihydroxybenzophenone and 2-hydroxy-4-methoxybenzophenone-. 5-sulfonate, 2- (2-hydroxy-5-
Methylphenyl) benzotriazole, urocanic acid,
And ethyl urocanate.

The external preparation for skin of the present invention may further contain known active ingredients as long as the effectiveness of the combination component of the present invention is not impaired. Examples thereof include vitamin E derivatives such as vitamin E nicotinate and vitamin E linoleate; diisopropylamine dichloroacetate; γ-amino-β-hydroxybutyric acid; citric acid;
α-hydroxy acids such as α-hydroxyoctanoic acid; crude drug extracts such as gentian extract;

Next, the present invention will be described more specifically with reference to Production Examples, Examples and Test Examples, but the present invention is not limited thereto. In the following, parts means parts by weight.

Production Example 1 Preparation of Rice Bran Extract Hydrolyzate Solution 200 g of rice bran was added to a 0.1 N sodium hydroxide aqueous solution 8
The sample was immersed in 00 ml at room temperature for 24 hours. Next, insoluble materials were removed by filtration, and the filtrate was sequentially treated with actinase, pepsin and trypsin. Enzyme treatment, each enzyme 10mg
Each enzyme was maintained at 40 ° C. for 2 hours at the optimum pH for each enzyme. The enzyme-treated solution obtained here was filtered to give a yellow transparent rice bran extract hydrolyzate solution (solid content: about 1.0% by weight, weight average molecular weight: 25%).
300 ml).

Production Example 2 Preparation of Rice Bran Extract Hydrolyzate Solution In the same manner as in Production Example 1 except that papain was used instead of pepsin, a rice bran extract hydrolyzate solution (solid content: about 1.0%) was used. Weight%, weight average molecular weight: 2500 or less)
300 ml were obtained.

Production Example 3 Preparation of Rice Bran Extract Hydrolyzate Solution 100 g of rice bran was immersed in 400 ml of 0.25 N aqueous sodium hydroxide at room temperature for 24 hours. Next, the insolubles were removed by filtration, and the filtrate was adjusted to pH 10 with a 2N aqueous sodium hydroxide solution, and then kept at 80 ° C. for 2 hours. The treatment liquid obtained here was filtered to obtain 200 ml of a yellow transparent rice bran extract hydrolyzate solution (solid content: about 1.0% by weight, weight average molecular weight: 2500 or less).

Preparation Example 4 Preparation of Rice Bran Extract Hydrolyzate Powder 200 ml of the rice bran extract hydrolyzate solution prepared in the same manner as in Preparation Example 1 was concentrated and freeze-dried. 0 g was obtained.

Example 1 Cream [Component A] Part Liquid paraffin 5.0 Hexalan (Glyceryl trioctanoate manufactured by Technoble Co., Ltd.) 4.0 Paraffin 5.0 Glyceryl monostearate 2.0 Polyoxyethylene (20) sorbitan Monostearate 6.0 butylparaben 0.1 [Component B] Solution of hydrolyzate of rice bran extract obtained in Production Example 1 3.0 Kojic acid 1.0 Glycerin 5.0 Carboxymethyl monostearate 0.1 Methylparaben 0.1 Moiston C (NMF component manufactured by Technoble Co., Ltd.) 1.0 Amount of purified water to make the total amount 100 parts [Component C] Perfume Appropriate amount After heating the above components A and B to 80 ° C. or higher, respectively. , Mixed and stirred. After cooling to 50 ° C., the C component was added and further stirred and mixed to prepare a cream.

Example 2 Emulsion [Component A] Part Liquid paraffin 6.0 Hexalan (Glyceryl trioctanoate manufactured by Technoble Co., Ltd.) 4.0 Jojoba oil 1.0 Polyoxyethylene (20) sorbitan monostearate 2.0 Soybean lecithin 1.5 Methylparaben 0.15 Ethylparaben 0.03 [Component B] Rice bran extract hydrolyzate solution obtained in Production Example 2 3.0 Kojic acid 1.0 Glycerin 3.0 1,3-butylene glycol 2.0 Carboxymethylcellulose 0.3 Sodium hyaluronate 0.01 Purified water Amount that makes the total amount 100 parts [Component C] Fragrance Appropriate amount The above components A and B were each heated to 80 ° C. or higher, and then mixed and stirred. After cooling to 50 ° C., the C component was added and further stirred and mixed to prepare an emulsion.

Example 3 Lotion [Components] Part Hydrolyzate solution of rice bran extract obtained in Preparation Example 3.0 Arbutin 1.0 Ethanol 10.0 Glycerin 3.0 1,3-butylene glycol 2.0 Methylparaben 0.2 Citric acid 0.1 Sodium citrate 0.3 Carboxyvinyl polymer 0.1 Perfume Appropriate amount Purified water Amount to make the total amount 100 parts The above components were mixed to prepare a lotion.

Example 4 Pack [Components] Part Polyvinyl alcohol 15.0 Hydroxymethylcellulose 5.0 Propylene glycol 5.0 Ethanol 10.0 Methylparaben 0.2 Hydrolyzate of rice bran extract obtained in Production Example 3 0 Magnesium L-ascorbic acid-2-phosphate ester 1.0 Perfume Appropriate amount Purified water An amount that gives a total amount of 100 parts The above components were mixed and stirred to prepare a pack.

Example 7 Cream A cream was prepared in the same manner as in Example 1 except that 1.0 part of arbutin was used instead of 1.0 part of kojic acid.

Example 8 Cream In Example 1, instead of 1.0 part of kojic acid, magnesium salt of L-ascorbic acid-2-phosphate ester was used.
A cream was prepared in the same manner as in Example 1 except that 0 part was used.

Example 9 Cream A cream was prepared in the same manner as in Example 1, except that 1.0 part of L-ascorbic acid-2-glucoside was used instead of 1.0 part of kojic acid. .

Example 10 Cream In Example 1, 4-n was used in place of 1.0 part of kojic acid.
A cream was prepared in the same manner as in Example 1 except that 1.0 part of -butylresorcinol was used.

Example 11 A cream was prepared in the same manner as in Example 1, except that 1.0 part of kojic acid was used instead of 1.0 part of ellagic acid.

Example 12 Cream A cream was prepared in the same manner as in Example 1 except that 1.0 part of placental extract was used instead of 1.0 part of kojic acid.

Example 13 Cream In Example 1, instead of 1.0 part of kojic acid, 1.0 part of L-ascorbic acid-2-glucoside and gentian extract [Infran-AT, manufactured by Technoble Co., Ltd.] , Solid content 2.3%] A cream was prepared in the same manner as in Example 1 except that 1.0 part was used.

Comparative Example 1 Cream The preparation of the cream of Example 1 was the same as that of Example 1 except that the hydrolyzate of rice bran extract and kojic acid (1.0 part) were used alone instead of kojic acid. A cream was prepared in the same manner.

Comparative Example 2 Cream In the preparation of the cream of Example 7, instead of the hydrolyzate of rice bran extract and arbutin, arbutin (1.0 part) was used.
A cream was prepared in the same manner as in Example 7, except that lipstick was used alone.

Comparative Example 3 Cream In preparing the cream of Example 8, instead of the hydrolyzate of rice bran extract and magnesium L-ascorbic acid-2-phosphate, L-ascorbic acid-2-phosphate was used. A cream was prepared in the same manner as in Example 8, except that the ester magnesium salt (1.0 part) was used alone.

Comparative Example 4 Cream In the preparation of the cream of Example 9, L-ascorbic acid-2-glucoside (1.0 part) was used instead of the rice bran extract hydrolyzate and L-ascorbic acid-2-glucoside. )
A cream was prepared in the same manner as in Example 9 except that the cream was used alone.

Comparative Example 5 Cream In the preparation of the cream of Example 10, the rice bran extract hydrolyzate and 4-n-butylresorcinol were replaced with 4-
A cream was prepared in the same manner as in Example 10, except that n-butyl resorcinol (1.0 part) was used alone.

Comparative Example 6 The procedure of Example 11 was repeated, except that ellagic acid (1.0 part) was used alone in place of the hydrolyzate of rice bran extract and ellagic acid in the preparation of the cream of Example 11. To prepare a cream.

Comparative Example 7 Cream In the preparation of the cream of Example 12, the placenta extract (1.0%) was used instead of the rice bran extract hydrolyzate and the placenta extract.
A cream was prepared in the same manner as in Example 12 except that (Part) was used alone.

Test Example 1 Pigmentation Inhibition Test The synergistic effect of using a combination of a rice bran extract hydrolyzate and various whitening agents was examined by a pigmentation inhibition test using a colored guinea pig.

[Sample] An aqueous solution containing each component at the solid content concentration (% by weight) shown in Table 1 was used as a sample.

[Table 1]

In Table 1, RH, KA, AL, AP
M, AG, EA, BR and PE mean the following, respectively. RH: Rice bran extract hydrolyzate, KA: Kojic acid, AL:
Arbutin, APM: L-ascorbic acid-2-phosphate magnesium salt, AG: L-ascorbic acid-
2-glucoside, EA: ellagic acid, BR: 4-n-butylresorcinol, PE: placenta extract

[Test Method] The body of a colored guinea pig (♂, 8-week-old) with a length of 60 mm in the center of the back and a width of 30 mm was shaved, and this part was divided into four parts, namely front and rear, left and right. The sample of the present invention was placed in one of the sections, and any of Comparative Samples A, B, and C to F was placed in the remaining three sections, twice each in the morning and evening.
μl was applied for 6 days, and the applied site was irradiated with UV-B of 500 mJ / cm ² once daily immediately before application in the morning, and the pigmentation state of the irradiated site was visually observed on the evening of the sixth day. Was evaluated according to the following criteria. [Criteria for judging pigmentation]-: No pigmentation observed ±: Minor pigmentation observed +: Mild pigmentation observed 2+: Moderate pigmentation observed 3+: Severe pigmentation observed

[Results] The results are shown in Table 2.

[Table 2]

From the results in Table 2, it can be seen that when the hydrolyzate of rice bran extract and the existing whitening agent are used in combination, the effect of inhibiting pigmentation is remarkably improved as compared with the case where these components are used alone.
It can be seen that the whitening effect is synergistically enhanced by the combined use.

Test Example 2 Monitor Test 1 The creams of Examples 1, 7 to 12 and Comparative Examples 1 to 7 were examined for their inhibitory effects on skin pigmentation. [Test Method] Thirty randomly selected females aged 18 to 55 were used as subjects, and each cream was applied twice a day (morning,
Evening) The composition was applied to the left and right armpits for one month, the state of pigmentation of the applied area was visually observed, and evaluated based on the following evaluation criteria.

[Evaluation Criteria] A: Pigmentation disappeared B: Pigmentation was clearly reduced C: Pigmentation was less than before using cream D: Almost no change from before using cream No E: More pigmentation than before using the cream

[Results] The results are shown in Table 3.

[Table 3]

As shown in Table 3, the combined use of the hydrolyzate of rice bran extract of the present invention and an existing whitening agent can provide a higher pigmentation preventing effect as compared with the case where the whitening agent is used alone.

Test Example 3 Monitor Test No. 2 The creams of Examples 1, 7 to 12 and Comparative Examples 1 to 7 were examined for their effects on the suppression of erythema and pigmentation during ultraviolet irradiation.

[Test Method] Age randomly selected from 18
Thirty-five-year-old female subjects were the subjects, and one
Two UV irradiation sections of cm × 1 cm were set. UV-
Using a B-lamp (FL20-SE, manufactured by Toshiba Corporation), ultraviolet rays of an amount corresponding to the minimum erythema volume (MED) of each subject measured in advance once a day (morning) for three consecutive days And irradiated. One month after the UV irradiation start date, during the UV irradiation period (first three days), immediately after UV irradiation and twice a day in the evening, and after the UV irradiation period (after the fourth day), in the morning and evening. Example 1, 7 to 2 times a day
12 or the creams of Comparative Examples 1 to 7 were applied. After one month, the erythema development and pigmentation of the ultraviolet-irradiated part of each subject were visually observed and evaluated based on the following evaluation criteria.

[Evaluation Criteria] A: No erythema and no pigmentation B: Clearly reduced erythema and pigmentation C: Less erythema and pigmentation than before use of cream D: Little change from before cream use E: Erythema and pigmentation increased more than before cream use

[Results] The results are shown in Table 4.

[Table 4]

As shown in Table 4, when the rice bran extract hydrolyzate is used in combination with an existing whitening agent, the effects of inhibiting erythema and pigmentation are significantly enhanced.

[0064]

Effect of the Invention According to the external preparation for skin of the present invention comprising a combination of an existing whitening agent and a hydrolyzate of rice bran extract, the whitening effect is markedly enhanced by the synergistic effect of the components, and the whitening agent alone As compared with the case of (1), the pigmentation of the skin is more remarkably suppressed, and an excellent effect of preventing spots and freckles and improving symptoms is exhibited. In addition, by enhancing the whitening effect, the amount of the whitening agent required to obtain the desired effect can be adjusted, and there is no side effect such as skin irritation often observed when the whitening agent is highly blended, and safety. It is possible to provide an external preparation for skin having a high level.

──────────────────────────────────────────────────の Continued on the front page (51) Int.Cl. ⁷ Identification symbol FI Theme coat ゛ (Reference) A61K 7/00 A61K 7/00 CH 35/78 ADA 35/78 ADAW F-term (Reference) 4C083 AA011 AA071 AA072 AA111 AA112 AA122 AC012 AC022 AC102 AC122 AC302 AC311 AC312 AC352 AC422 AC442 AC471 AC472 AC482 AC841 AC842 AD092 AD112 AD272 AD282 AD332 AD391 AD392 AD471 AD472 AD572 AD641 AD642 CC02 CC04 CC05 CC07 DD23 DD31 EE10 EE16 FF01 AB03MA03 AB03MA03 MA63 NA14 ZA89

Claims (4)

[Claims] 1. A whitening agent selected from the hydrolyzate of rice bran extract and kojic acid and its derivatives, arbutin, ascorbic acid and its derivatives, ellagic acid, resorcinol derivatives, placental extracts, soybean extract and yukinoshita extract. An external preparation for skin, comprising one or more of the following. 2. The external preparation for skin according to claim 1, wherein the hydrolyzate of the rice bran extract is obtained by treating an alkaline extract of rice bran with two or more proteases. 3. The method according to claim 1, wherein the protease is a combination of (a) actinase and (b) one or more selected from the group consisting of pepsins, trypsins, papains, peptidases and bromelain. Item 3. An external preparation for skin according to item 2. 4. A whitening agent comprising kojic acid, arbutin, L-ascorbic acid-2-phosphate magnesium salt,
-Ascorbic acid-2-glucoside, ellagic acid and 4-
The external preparation for skin according to claim 1, wherein the external preparation is selected from n-butyl resorcinol, an extract of somaria, and an extract of saxifrage.