JPH0925213A - Skin preparation for external use - Google Patents

Abstract

PROBLEM TO BE SOLVED: To obtain a skin preparation for external use having excellent effects on the docolorizing and whitening of chromatosis, spot, freckle, chloasma, etc., after sunburn and having excellent in protease inhibiting effect by using an extract of a specific plant of family Sterculiaceae. SOLUTION: This preparation contains an extract of a plant belonging to genus Scapium in family Sterculiaceae. As the plant, especially Buah tempayang is preferable. The extract is obtained by dipping stalks, fruits and whole herbs containing leaves, barks and rhizomes of the plant in an extracting solvent or heat-refluxing together with the solvent, filtering and condensing. A mixing amount of the extract is preferably 0.005-20.0wt.% as a dry material based on the weight of the whole preparation for external use. The skin preparation for external use is useful as a preparation for whitening or for improvement of skin roughness.

Description

Detailed Description of the Invention

[0001]

FIELD OF THE INVENTION The present invention is applicable to the Aogiri (Sterculiacea).
e) An external preparation for the skin containing an extract of the genus Scapium, more specifically, it suppresses the production of melanin, and is effective in preventing and improving pigmentation, spots, freckles, chloasma, etc. after sunburn. And contact dermatitis,
The present invention relates to an external preparation for skin which has an improving / preventing effect on various skin diseases such as psoriasis as well as skin roughness and roughness caused by dryness, detergent and the like.

[0002]

BACKGROUND OF THE INVENTION Although there are some unclear points about the mechanism of the generation of skin spots and the like, it is generally caused by hormonal abnormalities and irritation of ultraviolet rays from sunlight. It is believed that melanin pigment is formed, which is abnormally deposited in the skin. This melanin pigment, which causes skin coloring, is produced in the melanin-producing granules (melanosomes) in the melanocytes (melanocytes) between the epidermis and the dermis, and the produced melanin diffuses into adjacent cells by osmotic action. . The biochemical reaction in this melanocyte is presumed to be as follows. That is, tyrosine, which is an essential amino acid, is converted into dopaquinone by the action of the enzyme tyrosinase, and the process in which it is converted to black melanin via a red pigment and a colorless pigment by an enzymatic or non-enzymatic oxidative action is a melanin pigment production process. Therefore, suppressing the action of tyrosinase, which is the first step of the reaction, is important for suppressing melanin production.

However, except for hydroquinone, the compounds that suppress the action of tyrosinase have extremely slow onset of their effects, and therefore the effect of improving skin pigmentation is not sufficient. On the other hand, although hydroquinone is recognized as having an effect, its use is generally restricted because of its sensitizing properties. In order to improve the safety, attempts have been made to use monoesters or alkyl monoethers of higher fatty acids (Japanese Patent Application Laid-Open No. 58-154507), but the esters are decomposed by hydrolytic enzymes in the body. For this reason, it is not always safe to say, and ethers have not been obtained that are sufficiently satisfactory in terms of safety.

On the other hand, in recent years, it has been revealed that proteases are involved in the pathological formation of various skin diseases. For example, in psoriasis, which is a representative of inflammatory dyskeratosis, high plasminogen activator (PA) activity is observed in the affected epidermis. While PA is one of the serine proteases, Haustein reports that strong PA activity is present in psoriatic epidermis, especially at the site of parakeratosis (Arch. Klin. Exp.
Dermatol; 234, 1969), Fraki and Hopsu-Ha
vu extracted PA activity from psoriatic scales using a high concentration salt solution (Arch. Dermatol. Res; 256,1976). Also,
In pemphigus vulgaris, a large amount of PA synthesized in epidermal cells is converted into extracellular plasminogen (Plasmini).
gen) to plasmin, which digests intercellular binders to store interstitial fluid between cells and form blisters in the epidermis.
itro) in experimental systems (Morioka
S. et al: J. Invest. Dermatol; 76,1981). Proteases are also considered to play an important role in the normal keratinization process of the epidermis such as stratum corneum formation (Ogaw
a H., Yoshiike T .: Int. J. Dermatol; 23, 1984), and attempts have been made to use protease inhibitors as agents for improving skin or treating skin diseases.

[0005]

In view of the above situation, the present inventors have investigated a melanin production inhibitory effect and a protease inhibitory activity for a wide variety of substances. As a result, the Scapium (Scapiu) family of the Sterculiaceae family has been investigated.
It was found that the extracts of m) plants have melanin production inhibitory action and protease inhibitory action. Furthermore, it has been found that the plant extract very effectively improves rough skin. There has been no report about the melanin production inhibitory action of an extract of a plant of the genus Scapium of the family Asteraceae (Sterculiaceae), and its application to a whitening agent or a skin roughening agent has not been known at all. Further, there is no example in which an external preparation for the skin is mixed with an extract of a plant of the genus Scapium of the family Sterculiaceae. The present inventors have completed the present invention based on the above findings.

[0006] That is, the present invention is based on Aoiri (Sterculiac
The external preparation for skin is characterized by containing an extract of a plant belonging to the genus Scapium of the family eae).

Hereinafter, the configuration of the present invention will be described in detail. Examples of plants belonging to the genus Scapium of the family Sterculiaceae used in the present invention include, for example, Buah tempayang, scientific name: Scapium.
affinis Pierre) is preferred. This is a plant that grows especially on dry grasslands, pastures and the like in Indonesia. The extract used in the present invention is obtained by immersing or heating and refluxing whole plants such as leaves, bark, stems including rhizomes, fruits, etc. with an extraction solvent, filtering and concentrating. The extraction solvent used in the present invention is not particularly limited as long as it is a solvent usually used for extraction. In particular, an organic solvent such as alcohols such as methanol and ethanol, aqueous alcohols, acetone, and ethyl acetate is used alone or in combination. Can be.

In the present invention, Aogiri (Sterculiacea)
e) The compounding amount of the extract of the genus Scapium is 0.005 to 20.0 as a dried product in the total amount of the external preparation.
%, Preferably 0.01-10.0% by weight.
If the amount is less than 0.005% by weight, the effects of the present invention are not sufficiently exhibited, and if the amount is more than 20.0% by weight, it is not preferable because formulation is difficult. Further, even if the content is 10.0% by weight or more, the effect is not so much improved.

The external preparation for skin of the present invention is preferably applied as a whitening agent, a rough skin improving agent and a protease inhibitor. Protease, which is a protease inhibitor, is a general term for enzymes that catalyze the hydrolysis of peptide bonds, and this protease is classified into peptidases and proteinases. The former is an enzyme that cleaves a peptide bond from the outside of the amino group terminal or the carboxyl group terminal of the peptide chain, and the latter is an enzyme that cleaves a specific bond inside the peptide chain. The latter proteinases are further roughly classified into four types, serine, cysteine, aspartic acid, and metal, depending on the type of active catalytic group, and each has a specific inhibitor. The protease inhibitor in the present invention is characterized by exhibiting inhibitory activity against serine protease among them.

The external preparation for skin of the present invention contains, in addition to the above-mentioned essential components, components that are usually used in external preparations for skin such as cosmetics and pharmaceuticals, for example, other whitening agents, moisturizing agents, antioxidants,
An oily component, an ultraviolet absorber, a surfactant, a thickener, an alcohol, a powder component, a coloring material, an aqueous component, water, various skin nutritional agents and the like can be appropriately blended as necessary.

Other metal sequestering agents such as disodium edetate, trisodium edetate, sodium citrate, sodium polyphosphate, sodium metaphosphate, gluconic acid, caffeine, tannin, verapamil, tranexamic acid and its derivatives, licorice extraction Substance, glabridin, hot water extract of fruits of fire thorns, various crude drugs, tocopherol acetate,
Drugs such as glycyrrhizic acid and its derivatives or salts thereof, vitamin C, magnesium ascorbate phosphate,
Other whitening agents such as ascorbic acid glucoside, arbutin, kojic acid, glucose, fructose, mannose,
Sugars such as sucrose and trehalose can also be appropriately blended.

The external preparation for skin of the present invention may be any ointment, cream, milky lotion, lotion, pack, bath agent or the like as long as it is a conventional external preparation for skin, and its form is not particularly limited.

[0013]

Next, the present invention will be described in more detail by way of examples. Note that the present invention is not limited by this. The compounding amount is% by weight. Prior to the examples, test methods and results of the melanin suppressing effect, tyrosinase activity inhibiting effect and whitening effect, and protease inhibiting effect and skin roughening improving effect of the plant extract of the present invention will be described.

Test methods for melanin inhibitory effect, tyrosinase activity inhibitory effect and whitening effect and their results 1. Preparation of sample 50 g of fruit portion of Buah tempayang was immersed in ethanol at room temperature for 1 week,
The extract was concentrated to obtain 2.7 g of ethanol extract. This extract was dissolved in DMSO at 1%, the concentration was adjusted by diluting this solution, and the following experiment was performed using this.

2. Cell culture method B16 melanoma cultured cells derived from mice were used. 1
0% FBS and theophylline (0.09 mg / ml)
The cells were cultured in an Eagle MEM medium containing C. in a CO ₂ incubator (95% air, 5% carbon dioxide) at 37 ° C. After 24 hours of culturing, the sample solution was added so as to have a final concentration (concentration of extracted dry matter) of 10 ^-2 to 10 ^-5 % by weight, culturing was continued for another 3 days, and the melanin production amount was visually sensed by the following method. The determination and the tyrosinase activity inhibitory effect were measured.

3. Visual measurement of melanin amount A diffuser plate was placed on the lid of the plate of the well, the intracellular melanin amount was observed with an inverted microscope, and compared with the case of the sample (standard) to which the plant extract was not added. Table 1 shows the results.
Displayed in. In addition, as a reference example, the same test as above was carried out on an extract of Kaigai (Lamiaceae, Odorikosou Subfamily), which is already known to have an action of suppressing melanin production. Table 1 also shows the results.

<Judgment Criteria> ◯: White (amount of melanin) Δ: Slightly white (amount of melanin) ×: Reference (amount of melanin)

4. Measurement of tyrosinase activity Before measurement, the medium in the wells is removed and washed twice with 100 μl of PBS. 45 μl of 1% Triton-X in each well
(Rohm and Haas product name, surfactant) containing PBS is added. Shake the plate for 1 minute, break the cell membrane well, and use a microplate reader for 475n.
The absorbance at m was measured, and this was taken as the absorbance at 0 minutes. Then, 5 μl of 10 mM L-DOPA solution was quickly added, and the mixture was transferred to an incubator at 37 ° C. and reacted for 60 minutes. The plate was shaken for 1 minute, and the absorbance (475 nm) at 60 minutes was measured. The tyrosinase activity ratio (%) was defined as the ratio of the absorbance difference of the sample with the plant extract to the absorbance difference between the time of 0 minute and the time of 60 minutes in the case of the sample to which no plant extract was added (control). Table 1 shows the results. Further, as a reference example, the same test as above was carried out on an ethanol extract of mussel, which is already known to have a tyrosinase activity inhibitory action. Table 1 also shows the results. In addition,-in a table | surface means that the significant difference was not recognized within 5% of the risk ratio compared with the control.

[0019]

[Table 1] ─────────────────────────────────── Test Melanin production Visual evaluation Tyrosinase activity rate (% ) ──────── ─────────── ──────────── Concentration (wt%) 10 ^-5 10 ^-4 10 ^-3 10 ^-2 10 ^-5 10 ^-4 10 ^-3 10 ^-2 ─────────────────────────────────── Bua Tempayan extraction Material × × × ○ 72 72 75 47 Kaigai Extract × × × × − − − 55 ─────────────────────────────── ─────

[5] Whitening test [Test method] 40 subjects exposed to sunlight in summer for 4 hours (2 hours per day for 2 days) each sample from 5 days after the day of sun exposure to the skin of the upper arm inner skin Was applied once each morning and evening for 4 weeks. The panel was divided into 8 groups, and 5 groups were prepared, and the tests were conducted according to the formulations shown below. (Alcohol phase) 95% Ethyl alcohol 55.0% by weight Polyoxyethylene (25 mol) hydrogenated castor oil ether 2.0 Antioxidant / preservative proper amount Fragrance proper amount drug (listed in Table 2) (water phase) glycerin 5.0 Sodium hexametaphosphate Suitable amount Ion-exchanged water Residue <Production method> An aqueous phase and an alcohol phase are prepared, respectively, and then both are mixed and solubilized.

[Evaluation Method] The lightening effect after use was judged based on the following judgment criteria. <Judgment criteria> ：: When the ratio showing significant effect and effectiveness among the subjects is 80% or more 割 合: The ratio showing significant effect and effectiveness among the subjects is 50% or more
Less than 80% △: The proportion of the test subjects showing excellent and effective is 30% or more
When less than 50% x: When the ratio of markedly effective or effective among the subjects is less than 30%

Samples having the blending composition described in the above test method were prepared and the whitening effect was compared using the agents shown in Table 2.
The results are shown in Table 2.

[0023]

[Table 2] ──────────────────────────────────────────────────────────────── ─────────────── No additive − × Hydroquinone 1.0 △ Bua Tempayan extract 0.1 ○ Bua Tempayan extract 1.0 ○ Bua Tempayan extract 10.0 ◎ ──────────────────────────

The Bua Tempayan extract of Table 2 is
It is obtained by heating and reducing the fruits of Bua Tempayan in ethanol, filtering and concentrating and drying.

As is clear from Table 2, the effect after exposure to sunlight is that the addition of the Bua Tempayan extract can prevent excessive melanin pigment deposition and prevent darkening. Admitted.

Test method for protease inhibitory effect and rough skin improving effect and its results 1. Protease inhibitory effect test The inhibitory activity on plasmin and trypsin was evaluated as two representative serine proteases.

(1) Preparation of Sample The fruit portion of Buah tempayang was immersed in ethanol for 1 week at room temperature, and the extract was concentrated to dryness. Dissolve this solid in ethanol again,
A 1% solution was made.

(2) Measurement of plasmin inhibitory activity The inhibition rate was determined by the fibrin plate method. That is, As
Prepare a fibrin plate according to the method of trup et al. (Arch. B-iochem .; 40,346,1952), and use the sample prepared as above diluted with ethanol to 0.1% and 0.01%. did. The results are shown in Table 3.

(3) Measurement of trypsin inhibitory activity Muramatu et al. (J. Bioche) using casein as a substrate.
m .; 58, 214, 1965) and the inhibition rate was determined. Samples were also diluted to 0.1% and 0.01%, and the results are shown in Table 3. In addition, as a reference example, Kunyi (Zingiberaceae), which is a plant whose application is already known for rough skin, is
t, scientific name: Curcuma domestica), ginger (Zingibera)
Lempuyang (scientific name: Zi)
ngiber aromaticum Mal.) and the ethanolic extract of mugwort were subjected to the same test as above. Table 3 also shows the results.

[0030]

[Table 3] ───────────────────────────────── Inhibition rate (%) Sample addition concentration ───── ────────── Plasmin trypsin ───────────────────────────────── BUA Tempayan 0.1% 46.3 40.0 0.01% 22.9 20.1 Khun-it 0.1% 3.0 0 0.01% 0 0 Rempuyang 0.1% 0 0 0.01% 0 0 Artemisia 0.1% 18.6 0 0.01% 5.8 0 ───────────────── ────────────────

2. Skin roughness improvement effect test (1) Practical use test The effect of the external preparation of the present invention applied to the skin was evaluated based on the improvement rate against skin roughness, razor loss and pigmentation, and skin irritation. Using the face of a panel of 60 women suffering from rough skin, of the lotions having the composition (% by weight) shown in Table 4, the sample was placed on one of the left and right cheeks, and the other cheek was a control twice a day for 2 weeks. After application, the skin condition after that was visually evaluated. Further, a panel of 30 men who lost razors was applied with a lotion having the composition shown in Table 4 immediately after shaving, and the effect on razor loss was evaluated.
Each criterion was as follows. As samples, two kinds of products of the present invention with different concentrations of methanol extract of Bua Tempayan were used, and as a comparative product, ginger (Zingiber) which is a plant already known to be applied to rough skin.
Kyunit of the aceae family (scientific name: Curcuma
domestica) and ginger (Zingiberaceae) family Lempuyang (scientific name: Zingiber aroma)
ticum Mal.) mixed with a methanol extract was used. The results are shown in Table 5.

Criteria for the improvement effect on rough skin: Remarkable effect: symptom disappeared. Effective: those with reduced symptoms. Somewhat effective: Somewhat weakened symptoms. Ineffective: No change in symptoms.

Criteria for Improvement Effect on Razor Loss Remarkable effect: Razor loss disappeared. Effective: Razor loser weakened. Somewhat effective: Razor losing slightly weakened. Invalid: No change in razor loss.

Improvement Effect on Skin Roughness and Razor Loss ⊚: The rate at which the test subject is markedly effective, effective and slightly effective (effective rate) is 80% or more. ：: The proportion (effective rate) at which the test subject shows a remarkable effect, an effective effect and a somewhat effective effect is 50% or more and less than 80%. Δ: The ratio (effective rate) at which the test subject showed remarkable, effective, and somewhat effective (effective rate) was 30% or more and less than 50%. ×: The ratio (effective rate) at which the subject exhibited significant, effective, and somewhat effective (effective rate) was less than 30%.

Skin irritation ⊚: 0% of the subjects recognized tingling on the skin. ：: The proportion of subjects who felt tingling on the skin was less than 5%. Δ: The ratio of subjects who felt burning on the skin was less than 10%. ×: The proportion of subjects who felt burning on the skin was 10% or more.

[0036]

[Table 4] ──────────────────────────────── Inventive product Comparative product Test product ─────── ─────── 1 2 1 2 ──────────────────────────────── Bua Tempayan Methanol extract 1.0 0.5 --- Khun-it methanol extract --- 1.0- Rempuyan methanol extract ----1.0 Glycerin 10.0 10.0 10.0 10.0 1,3-butylene glycol 4.0 4.0 4.0 4.0 Ethanol 7.0 7.0 7.0 7.0 Polyoxyethylene (20 mol) Oleyl alcohol 0.5 0.5 0.5 0.5 Purified water Residual Residual Residual ──────────────────────────────────

[0037]

[Table 5] ──────────────────────────────── Comparative product of the present invention Sample ──────── ─────── 1 2 1 2 1 2 ──────────────────────────────── Skin roughening improvement effect ◎ ○ △ △ Razor loss prevention effect ◎ ○ △ △ Skin irritation ◎ ◎ ○ △ ──────────────────────────────────

As is apparent from Table 5, the sample of the present invention containing the Bua Tempayan extract showed a better effect on rough skin and razor loss than the sample of the comparative product, and further had an effect on skin irritation. Was not recognized.

(2) Actual Use Test by Replica Method Using lotions of the present invention products 1 and 2 and comparative products 1 and 2,
A human body panel was tested for the effect of improving rough skin. That is, the replica of the skin surface of a healthy female person (face) was sampled using a replica method with a millisin resin, and a microscope (17) was used.
Doubled). Based on the criteria shown in Table 6, the skin roughness was evaluated as 1 or 2 based on the condition of the skin pattern and the peeling condition of the stratum corneum.
The lotions of the products 1 and 2 of the present invention and the comparative products 1 and 2 were applied to the left and right half of the face twice a day for 2 weeks using 20 persons judged to be "poor skin". Two weeks later, the skin condition was observed again according to the above-mentioned replica method, and evaluated according to the criteria shown in Table 6. Table 7 shows the results.

[0040]

[Table 6] ───────────────────────────────── Rating Standards of Rating ──────── ─────────────────────────── 1 Disappearance of skin crevices, cuticles, and wide-ranging horny layer are observed. 2 Unsmooth skin groove and crust, and horny turn of the stratum corneum. 3 There are pits and ridges, but they are flat. 4 Clear skin grooves and ridges. 5 Crusts and ridges are clear and well organized. ─────────────────────────────────

[0041]

[Table 7] ──────────────────────────────── Replica evaluation Inventive product 1 Inventive product 2 Comparative product 1 Comparative Product 2 ──────────────────────────────── 1 0 0 1 0 2 0 1 3 4 3 4 3 6 6 13 13 11 4 15 13 3 5 5 1 0 0 0 ──────────────────────────────────

As can be seen from Table 7, the lotion of the product of the present invention had a remarkable effect of improving rough skin as compared with the lotion of the comparative product.

Example 1 Cream (formulation) Stearic acid 5.0% by weight Stearyl alcohol 4.0 Isopropyl myristate 18.0 Glycerin monostearate 3.0 Propylene glycol 10.0 Bua Tempayan methanol extract 0. 01 Caustic potassium 0.2 Sodium bisulfite 0.01 Preservative Suitable amount Perfume Suitable amount Ion-exchanged water Residual (production method) Propylene glycol and bua
Add Tempayan methanol extract and caustic potash to dissolve,
Heat and maintain at 70 ° C. (aqueous phase). The other components are mixed, melted by heating and kept at 70 ° C. (oil phase). The oil phase is gradually added to the water phase, and after the addition is completed, the temperature is maintained for a while to cause a reaction. After that, homogenize with a homomixer,
Cool to 30 ° C with good stirring.

Example 2 Cream (Formulation) Stearic acid 2.0% by weight Stearyl alcohol 7.0 Hydrogenated lanolin 2.0 Squalane 5.0 2-Octyldodecyl alcohol 6.0 Polyoxyethylene (25 mol) cetyl alcohol ether 3.0 Glycerin monostearate 2.0 Propylene glycol 5.0 Bua Tempayan ethanol extract 0.05 Sodium bisulfite 0.03 Ethylparaben 0.3 Perfume suitable amount Ion-exchanged water Residual (production method) To ion-exchanged water Add propylene glycol,
Heat and maintain at 70 ° C. (aqueous phase). The other components are mixed, melted by heating and kept at 70 ° C. (oil phase). The oil phase is added to the aqueous phase to carry out preliminary emulsification, and the mixture is uniformly emulsified with a homomixer and then cooled to 30 ° C. with thorough stirring.

Example 3 Cream (Formulation) Solid paraffin 5.0% by weight Beeswax 10.0 Vaseline 15.0 Liquid paraffin 41.0 Glycerin monostearate 2.0 Polyoxyethylene (20 mol) sorbitan monolaurate 2 0.0 Soap powder 0.1 Borax 0.2 Bua Tempayan acetone extract 0.1 Sodium bisulfite 0.03 Ethylparaben 0.3 Fragrance suitable amount Ion-exchanged water Residual (production method) Soap powder and borax in ion-exchanged water In addition, the mixture was heated and melted and maintained at 70 ° C. (aqueous phase). The other components are mixed, melted by heating and kept at 70 ° C. (oil phase). The oil phase is gradually added to the aqueous phase while stirring to carry out the reaction. After the reaction is completed, the mixture is uniformly emulsified with a homomixer, and after emulsification, the mixture is cooled to 30 ° C. with thorough stirring.

Example 4 Emulsion (formulation) Stearic acid 2.5 wt% Cetyl alcohol 1.5 Vaseline 5.0 Liquid paraffin 10.0 Polyoxyethylene (10 mol) monooleate 2.0 Polyethylene glycol 1500 3. 0 Triethanolamine 1.0 Carboxyvinyl polymer 0.05 (Brand name: Carbopol 941, BFGoodrich Chemical company) Bua Tempayan Acetic acid ethyl ester extract 0.01 Sodium bisulfite 0.01 Ethylparaben 0.3 Perfume proper amount Ion Exchanged water Residue (production method) A carboxyvinyl polymer is dissolved in a small amount of ion exchanged water (phase A). Polyethylene glycol 1500 and triethanolamine are added to the remaining ion-exchanged water, dissolved by heating, and kept at 70 ° C. (aqueous phase). The other components are mixed, melted by heating and kept at 70 ° C. (oil phase). The oil phase is added to the water phase to perform preliminary emulsification, the phase A is added, and the mixture is uniformly emulsified with a homomixer. After the emulsification, the mixture is cooled to 30 ° C. while stirring well.

Example 5 Emulsion (formulation) Microcrystalline wax 1.0 wt% Beeswax 2.0 Lanolin 20.0 Liquid paraffin 10.0 Squalane 5.0 Sorbitan sesquioleate 4.0 Polyoxyethylene (20 mol) ) Sorbitan monooleate 1.0 Propylene glycol 7.0 Bua Tempayan acetone extract 10.0 Sodium hydrogen sulfite 0.01 Ethylparaben 0.3 Perfume suitable amount Ion-exchanged water Residual (production method) Propylene glycol in ion-exchanged water And add
Heat and maintain at 70 ° C. (aqueous phase). The other components are mixed, heated and melted and kept at 70 ° C. (oil phase). While stirring the oil phase, the aqueous phase is gradually added thereto, and the mixture is uniformly emulsified with a homomixer. After emulsification, cool to 30 ° C with good stirring.

Example 6 Jelly (formulation) 95% ethyl alcohol 10.0 wt% dipropylene glycol 15.0 polyoxyethylene (50 mol) oleyl alcohol ether 2.0 carboxyvinyl polymer 1.0 (trade name: Carbopol 940, BFGoodrich Chemical company) Caustic soda 0.15 L-arginine 0.1 Bua Tempayan 50% ethanol aqueous solution extract 7.0 2-Hydroxy-4-methoxybenzophenone sodium sulfonate 0.05 Ethylenediaminetetraacetate-3 sodium-2 Water 0.05 Methylparaben 0.2 Perfume Suitable amount Ion-exchanged water Residual (production method) Carbopol 940 is uniformly dissolved in ion-exchanged water, while Bua Tempayan 50 is dissolved in 95% ethanol.
% Ethanol aqueous solution extract, polyoxyethylene (50
Mol) oleyl alcohol ether is dissolved and added to the aqueous phase. Next, after adding other components, the mixture is neutralized with caustic soda and L-arginine to increase the viscosity.

Example 7 Beauty Serum (Formulation) (Phase A) Ethyl Alcohol (95%) 10.0% by Weight Polyoxyethylene (20 mol) Octyldodecanol 1.0 Pantotenyl Ethyl Ether 0.1 Bua Tempayan Methanol extract 1.5 Methylparaben 0.15 (Phase B) Potassium hydroxide 0.1 (Phase C) Glycerin 5.0 Dipropylene glycol 10.0 Sodium hydrogen sulfite 0.03 Carboxyvinyl polymer 0.2 (trade name: Carbopol 940, BFGoodrich Chemical company) Purified water Residual (manufacturing method) Phases A and C are uniformly dissolved, and A is added to phase C
Add phases and solubilize. Next, after adding the phase B, filling is performed.

Example 8 Pack (formulation) (Phase A) 5.0% by weight dipropylene glycol Polyoxyethylene (60 mol) hydrogenated castor oil 5.0 (Phase B) Bua Tempayan methanol extract 0.01 Olive oil 5.0 Tocopherol acetate 0.2 Ethylparaben 0.2 Perfume 0.2 (C phase) Sodium hydrogen sulfite 0.03 Polyvinyl alcohol 13.0 (Saponification degree 90, degree of polymerization 2,000) Ethanol 7.0 Purified water Residual (manufacturing method) Phases A, B, and C are uniformly dissolved,
Add phase B to phase and solubilize. Next, this is added to the C phase and then filled.

Example 9 Solid foundation (formulation) Talc 43.1% by weight Kaolin 15.0 Sericite 10.0 Zinc white 7.0 Titanium dioxide 3.8 Yellow iron oxide 2.9 Black iron oxide 0.2 Squalane 8 0.0 Isostearic acid 4.0 POE sorbitan monooleate 3.0 Isocetyl octoate 2.0 Bua Tempayan ethanol extract 1.0 Preservative appropriate amount Fragrance appropriate amount (manufacturing process) Talc to black iron oxide powder component with a blender After thoroughly mixing and adding to it an oily component of squalane to isocetyl octoate, an extract of Bua Tempayan ethanol, a preservative and a fragrance, the mixture is well kneaded and then filled into a container and molded.

Example 10 Emulsion type foundation (cream type) (Formulation) (Powder part) Titanium dioxide 10.3% by weight Sericite 5.4 Kaolin 3.0 Yellow iron oxide 0.8 Bengala 0.3 Black iron oxide 0.2 (Oil phase) Decamethylcyclopentasiloxane 11.5 Liquid paraffin 4.5 Polyoxyethylene-modified dimethylpolysiloxane 4.0 (Aqueous phase) Purified water 50.0 1,3-Butylene glycol 4.5 Bua -Tempayan ethanol extract 1.5 Sorbitan sesquioleate 3.0 Preservative proper amount Perfume proper amount (Production method) After heating and stirring the aqueous phase, the powder portion thoroughly mixed and pulverized is added and treated with a homomixer. Further, the oil phase mixed by heating is added, and the mixture is treated with a homomixer. Then, a fragrance is added with stirring, and the mixture is cooled to room temperature.

[0053]

Industrial Applicability As described above, the external preparation for skin of the present invention has a melanin production inhibitory action and a tyrosinase activity inhibitory action, and it causes lightening of pigmentation, stains, freckles, melasma etc. after sunburn. In addition to having an excellent whitening effect, it also has an excellent effect of improving rough skin, and also has an excellent effect of improving various skin diseases, rough skin, rough skin, and the like.

─────────────────────────────────────────────────── ─── Continuation of the front page (51) Int.Cl. ⁶ Identification code Internal reference number FI Technical indication location A61K 35/78 ADS A61K 35/78 ADS AED AEDC C12N 9/99 C12N 9/99 (72) Inventor Yoshihiro Yokokawa 1050 Shinba-cho, Kohoku-ku, Yokohama-shi, Kanagawa Inside Shiseido Daiichi Research Center, Inc.

Claims (5)

[Claims] 1. An external preparation for skin, which comprises an extract of a plant of the genus Scapium of the family Sterculiaceae. 2. A plant belonging to the genus Scapium of the family Sterculiaceae is Buah Temph.
The external preparation for skin according to claim 1, which is empayang, scientific name: Scapium affinis Pierre). 3. The external preparation for skin according to claim 1, which is an external preparation for whitening. 4. The external preparation for skin according to claim 1, which is an external preparation for improving rough skin. 5. The compounding amount of the extract of the Scapium genus plant of the family Sterculiaceae is 0.005 to 5.
The external preparation for skin according to any one of claims 1 to 4, which is 20.0% by weight.