JP2003267856A - Wrinkle preventing cosmetic - Google Patents

Abstract

<P>PROBLEM TO BE SOLVED: To provide a stable wrinkle preventing cosmetic having excellent collagen synthesis promoting effects and collagen decomposition suppressing effects and carrying out prophylaxis or amelioration of a morphological change by aging of the skin. <P>SOLUTION: The wrinkle preventing cosmetic comprises ascorbic acid 2-phosphate and/or its salt and a higher fatty acid ester of the ascorbic acid 2-phosphate and/or its salt in combination. <P>COPYRIGHT: (C)2003,JPO

Description

Detailed Description of the Invention

[0001]

TECHNICAL FIELD The present invention relates to the following general formula (1)

[0002]

[Chemical 4]

Ascorbic acid-2-phosphate ester or / and salt thereof represented by: and (b) the following general formula (2)

[0004]

[Chemical 5]

Wrinkle prevention characterized by containing a higher fatty acid ester of ascorbic acid-2-phosphate ester represented by the formula (wherein R represents an acyl group of a higher fatty acid) or / and a salt thereof together. For cosmetics.
Wrinkle prevention means the overall effect of suppressing the formation of wrinkles, such as prevention and removal of wrinkles.

[0006]

2. Description of the Related Art The skin is constantly exposed to external stimuli, and wrinkles, sagging, dullness, pigmentation, etc. occur with age, and their properties change. Among them, the morphological changes such as wrinkles and sagging are considered to be mainly caused by the decrease of collagen fiber which is a main matrix component of the dermis.
Therefore, in order to prevent the generation of wrinkles and sagging of the skin, it is considered that effective promotion of collagen synthesis and inhibition of collagen degradation are effective means.

In recent years, prevention of morphological changes due to aging of the skin
Retinoids have been attracting attention as improving agents, and retinoic acid and retinol have come to be used as wrinkle-preventing cosmetics that promote collagen synthesis.

However, these agents are not only highly irritating to the skin but also extremely unstable substances, and can be compounded only with a special formulation technique and a special package. It was rare.

On the other hand, ascorbic acid phosphoric acid esters and salts thereof are known as agents having a collagen synthesis promoting effect. Ascorbic acid phosphate and its salts are transferred to the skin and converted to ascorbic acid, which promotes the synthesis of collagen and inhibits the activity of matrix metalloprotease (MMP) to suppress the degradation of collagen. Is. However, a sufficient effect on morphological changes due to aging has not yet been confirmed.

Further, Japanese Examined Patent Publication No. 5-28686 discloses a skin cosmetic containing a 6-O-higher acylascorbic acid phosphoric acid ester salt, which simultaneously exhibits a skin aging preventing effect and a whitening effect. There is a description.

However, there is no description as to whether the use of this skin cosmetic composition promotes or suppresses the synthesis of skin collagen, and it is not clear what mechanism the effect is based on.

[0012]

SUMMARY OF THE INVENTION An object of the present invention is to have an excellent effect of promoting collagen synthesis and an effect of suppressing collagen degradation, prevent and improve morphological changes due to aging of the skin, and prevent wrinkles from being stable. Is to provide a fee.

[0013]

Means for Solving the Problems As a result of intensive investigations by the present inventors in view of the above situation, the following general formula (1)

[0014]

[Chemical 6]

Ascorbic acid-2-phosphate ester or / and salt thereof represented by the following general formula (2)

[0016]

[Chemical 7]

Wrinkle prevention characterized by containing a higher fatty acid ester of ascorbic acid-2-phosphate ester represented by the formula (wherein R represents an acyl group of a higher fatty acid) or / and a salt thereof together. The cosmetics for cosmetics have been found to be useful, and have completed the present invention.

That is, the present invention relates to the following items. [1] (a) The following general formula (1)

[0019]

[Chemical 8]

Ascorbic acid-2-phosphate ester and / or salt thereof represented by: and (b) the following general formula (2)

[0021]

[Chemical 9]

Wrinkle prevention characterized by containing a higher fatty acid ester of ascorbic acid-2-phosphate ester represented by the formula (wherein R represents an acyl group of higher fatty acid) and / or a salt thereof. Cosmetics. [2] The cosmetic for preventing wrinkles according to the above [1], wherein the salt of ascorbic acid-2-phosphate ester is a sodium salt, a potassium salt, a magnesium salt or a zinc salt. [3] The following general formula (2)

[0023]

[Chemical 10]

(Wherein R represents an acyl group of a higher fatty acid), R is lauric acid, myristic acid, palmitic acid or stearic acid. In the above [1] or [2], The described wrinkle-preventing cosmetic. [4] The salt of a higher fatty acid ester of ascorbic acid-2-phosphate ester is a sodium salt, a potassium salt, a magnesium salt or a zinc salt, and the above-mentioned [1] to [3]. Cosmetics for preventing wrinkles.

[5] The cosmetic for preventing wrinkles according to the above [1] to [4], which contains an ultraviolet protective agent. [6] At least one selected from the group consisting of organic UV protection agents and inorganic UV protection agents as a UV protection agent
The cosmetic for preventing wrinkles according to the above [5], characterized in that one or more kinds are used.

[7] The organic UV protective agent is at least one selected from the group consisting of benzoic acid ester-based, salicylic acid-based, cinnamic acid-based, urocanic acid-based, benzophenone-based and oxybenzone-based UV protective agents. The cosmetic for preventing wrinkles according to the above [6], characterized by: [8] The cosmetic for preventing wrinkles according to any one of [1] to [7] above, which has a collagen synthesis promoting action.

[9] When the collagen synthesis promoting effect is measured by measuring the hydroxyproline content in the skin tissue by an amino acid analysis method and used as an index of the collagen synthesis promoting effect, the amount of hydroxyproline in the test group is 1 of the control group. The cosmetic for wrinkle prevention according to the above [8], which is in a range of 2 to 2 times. [10] The cosmetic for preventing wrinkles according to any one of the above [1] to [9], which has a wrinkle suppressing effect.

[0028]

BEST MODE FOR CARRYING OUT THE INVENTION In the present invention, the following general formula (1) is used.

[0029]

[Chemical 11]

Ascorbic acid-2-phosphate ester represented by and / or a salt thereof can be used, but a salt is preferable, and the salt will be described below.

Ascorbic acid-2-2 used in the present invention
The phosphoric acid ester may be any of D-form, L-form and DL-form, and is preferably the L-form, and as the salt, the phosphoric acid ester is bound to the 2-position of ascorbic acid, and the phosphoric acid group of the phosphoric acid ester is present. And a base to form a salt.

Ascorbic acid-2-phosphate ester salts include alkali metal salts, alkaline earth metal salts, and Zn.
Salt, Al salt, Ti salt and the like can be mentioned, but preferably,
Examples thereof include Na salt, K salt, Mg salt, and Zn salt. More preferred are Na salt and Mg salt. These may be used alone or in combination of two or more.

In the wrinkle-preventing cosmetic composition of the present invention, the amount of the ascorbic acid-2-phosphate ester salt is 0.01 to 20% by mass, preferably 0.03 to 20% by mass based on the total amount of the wrinkle-preventing cosmetic composition. 20% by mass, more preferably 0.05 to
It is 12 mass%.

Next, in the present invention, the following general formula (2)

[0035]

[Chemical 12]

A higher fatty acid ester of ascorbic acid-2-phosphate ester represented by and / or a salt thereof can be used, but a salt is preferable, and the salt will be described below.

In the above general formula (2), R represents an acyl group of a higher fatty acid. The higher fatty acid represents a C8 to C21 linear higher fatty acid, and examples thereof include caprylic acid, capric acid, lauric acid, myristic acid, palmitic acid, stearic acid, arachidic acid, and behenic acid. Among these, capric acid, lauric acid, myristic acid, palmitic acid, and stearic acid are preferable, and palmitic acid is particularly preferable.

Ascorbic acid-2-2 used in the present invention
Higher fatty acid ester of phosphoric acid ester is D-form, L-form,
Any of DL-form is preferable, and L-form is preferable, and as the salt, a phosphate ester is bound to the 2-position, a higher fatty acid is ester-bonded to the 6-position, and a phosphate group of the phosphate ester and a base are combined. It is a salt-forming compound.

Examples of salts of higher fatty acid ester of ascorbic acid-2-phosphate ester include alkali metal, alkali metal, Zn salt, Al salt, Ti salt and the like. Preferable ones include Na salt, K salt, Mg salt, Zn salt and the like, but Na salt is most preferable. These may be used alone or in combination of two or more.

In the cosmetic for preventing wrinkles of the present invention, the amount of the higher fatty acid ester salt of ascorbic acid-2-phosphate ester to be added is 0.01 to 20% by mass, preferably 0.0.
3 to 20% by mass, more preferably 0.05 to 12% by mass
Is.

The UV protective agent used in the wrinkle-preventing cosmetic of the present invention will be described. The ultraviolet protective agent used in the present invention is not particularly limited as long as it is usually blended with a skin external preparation, for example, benzoic acid ester-based, salicylic acid-based, cinnamic acid-based, urocanic acid-based, benzophenone-based, oxybenzone. It is selected from the group consisting of organic UV absorbers composed of a system or the like and inorganic UV protectors composed of an inorganic pigment or the like.

Examples of the UV protective agent used in the present invention include paraaminobenzoic acid, ethyl paraaminobenzoate, glyceryl paraaminobenzoate, amyl paradimethylaminobenzoate, octyl paradimethylaminobenzoate, and paradimethylaminobenzoic acid 2 -Ethylhexyl, 4- [N, N-di (2-hydroxypropyl)
Amino] benzoic acid ester such as ethyl benzoate; salicylate such as ethylene glycol salicylate, phenyl salicylate, octyl salicylate, 2-ethylhexyl salicylate, benzyl salicylate, p-tert-butylphenyl salicylate, homomentyl salicylate; benzyl cinnamate, 2-Ethoxyethyl paramethoxycinnamate, octyl paramethoxycinnamate, etc .; 2-ethylhexyl paramethoxycinnamate, glyceryl mono-2-ethylhexanoate diparamethoxycinnamate, paramethoxycinnamate Cinnamic acid-based compounds such as isopropyl cinnamate / diisopropyl cinnamic acid ester mixture, urocanic acid-based compounds such as urocanic acid and ethyl urocanate; hydroxymethoxybenzophenone, hydroxymethoxybenzophenone sulfonic acid, hyaluronan B carboxymethyl methoxybenzophenone sodium sulfonate,

Dihydroxydimethoxybenzophenone,
Examples thereof include benzophenone-based compounds such as sodium dihydroxydimethoxybenzophenone disulfonate, dihydroxybenzophenone, and tetrahydroxybenzophenone, and 4-tert-butyl-4′-methoxy-dibenzoylmethane, 2,4 as other organic UV protection agents.
6-trianilino-p- (carbo-2'-ethylhexyl-1'-oxy) -1,3,5-triazine, menthyl anthranilate, 2- (2-hydroxy-5-methylphenyl) benzotriazole and the like can be mentioned. .

Further, as an inorganic UV protection agent, red iron oxide, titanium oxide, chromium oxide, black iron oxide, zirconium oxide, yellow iron oxide, zinc oxide, alumina, magnesium oxide, barium sulfate, mica, talc, sericite,
Examples include dark blue, kaolin, aluminum hydroxide, ultramarine blue, montmorillonite, calcium carbonate, and silicic acid anhydride.

The blending amount of the UV protective agent used in the present invention is appropriately selected depending on the required UV protective effect, but is 0.01 to 40 relative to the total amount of the wrinkle preventing cosmetic composition.
It is mass%, preferably 0.03 to 30 mass%, preferably 0.05 to 20 mass%.

The wrinkle-preventing cosmetic of the present invention comprises alcohols such as ethanol and propylene glycol; preservatives such as methyl parahydroxybenzoate, ethyl parahydroxybenzoate, butyl parahydroxybenzoate and propyl parahydroxybenzoate. It can be obtained by blending purified water or the like with ascorbic acid-2-phosphate ester and its salt and higher fatty acid ester of ascorbic acid-2-phosphate ester and its salt.

The present invention relates to a cosmetic for preventing wrinkles, which comprises both ascorbic acid-2-phosphate ester and its salt and higher fatty acid ester of ascorbic acid-2-phosphate ester and its salt. It is characterized by having a collagen synthesis promoting action and a wrinkle formation inhibiting action. In the present invention, the collagen synthesis promoting effect means that when the hydroxyproline content in skin tissue is measured by an amino acid analysis method and used as an index of the collagen synthesis promoting effect, the amount of hydroxyproline in the test group is at least 1 of the control group. .2 to 2 times the range.

With regard to the effect of suppressing the formation of wrinkles, the effect of promoting the synthesis of collagen in skin tissue inhibits the activity of matrix metalloprotease (MMP) to suppress the decomposition of collagen and consequently suppress the formation of wrinkles. It is a thing.

Examples of wrinkle-preventing cosmetics include skin milk, skin cream, foundation cream,
Massage cream, cleansing cream, shaving cream, cleansing foam, lotion, lotion, pack, shampoo, conditioner, hair restorer, hair nourishing agent,
Hair dyes, hair styling agents, toothpastes, mouthwashes, permanent waving agents, ointments, bath agents, body soaps, etc. are broadly included, and there is no limitation as long as they come into contact with the skin during use. Also, it does not matter the sex or age of the user.

Further, the wrinkle-preventing cosmetic composition of the present invention may contain other components generally used in external preparations for the skin, as long as the effects of the present invention are not impaired. For example, known ingredients effective against skin aging, known ingredients effective for suppressing wrinkles, known whitening agents and the like can be mentioned.

Specifically, tea extract, L-lysine, L-
Arginine, caffeine, tannin, verapamil, tranexamic acid, tranexamic acid derivative, licorice extract, glabridin, hot water extract of karin fruit, various herbal medicines, tocopherol acetate, glycyrrhizic acid, glycyrrhizic acid derivative, arbutin, kojic acid, etc. Whitening agents; saccharides such as glucose, fructose, mannose, sucrose, trehalose; vitamin A derivatives such as retinoic acid, retinol, retinol acetic acid, retinol palmitic acid, and the like.

Further, various base ingredients and the like can be added depending on the dosage form of the dermatological agent. Specifically, liquid oils, solid oils, waxes, ester oils, hydrocarbon oils, silicone resins, silicones, anionic surfactants, anionic surfactants, cationic surfactants, amphoteric surfactants, Nonionic surfactant, lower alcohol, sterols,
Water-soluble polymers, sequestering agents (disodium edetate, trisodium edetate, sodium citrate, sodium polyphosphate, sodium metaphosphate, gluconic acid, etc.), neutralizers, pH adjusters, antibacterial agents, and fragrances Can be blended according to the specific use and purpose.

[0053]

The present invention will be described in detail below with reference to examples, but the present invention is not limited to these examples.

[Example 1] Human skin tissue three-dimensional model (TESTSKIN ^™ LSD-d, Toyobo Co., Ltd.)
Dulbecco P with the test substances of 1) to 3) below on the tissue surface of
Add 40 μL of the solution dissolved in BS (-), 37 ° C,
The cells were cultured in the presence of 5% CO ₂ for 2 hours. Thereafter, the test substance solution was aspirated, 37 ° C., 5% CO ₂ presence in 2,
It was cultured for 6 to 12 hours.

The skin model sampled at each culture time was washed with Dulbecco's PBS (-), the surface of the tissue on which the test substance was placed was punched out with a φ6 mm punch, and homogenized in HEPES buffer (pH 7.2) to obtain a skin model. Quantitative analysis of ascorbic acid in the mixture was performed using high performance liquid chromatography. The protein content in the skin model is L
Quantitative analysis was carried out by the owry method.

1) 2% Ascorbic acid-2-phosphate sodium salt 2) 1% Ascorbic acid-2-phosphate-6-
Palmitate sodium salt 3) 1% Ascorbic acid-2-phosphate sodium salt, 0.5% Ascorbic acid-2-phosphate ester-6-palmitate sodium salt

Measurement conditions for high performance liquid chromatography <ascorbic acid> Column: Shodex (registered trademark of Showa Denko KK)
Asahipak NH2P-50 4E Temperature: 40 ° C. Eluent: Acetonitrile: 60 mM H ₃ PO ₄ = 8
0:20 Flow rate: 0.8 ml / min Detection: UV245nm

<Ascorbic acid derivative> Column: Shodex (registered trademark of Showa Denko KK)
OHpak SB802.5 HQ Temperature: 40 ° C Eluent: 0.03M Na ₂ SO ₄ + 0.03MH
₃ PO ₄ / tetrahydrofuran = 1: 2 Flow rate: 0.5 ml / min Detection: UV 270 nm

The amount of ascorbic acid (unit: nmol / mg skin protein) at each test substance and each culture time was as follows. After 2 hours of culturing After 6 hours of culturing After 12 hours of culturing 1) 30 24 5 2) 6 10 23 3) 30 30 26

Ascorbic acid-2-phosphate sodium salt and ascorbic acid-2-phosphate-6-
When palmitate sodium salt is administered at the same time, it is possible to efficiently enrich the tissue concentration of ascorbic acid, which is effective in promoting collagen synthesis, for a long time immediately after the administration, as compared with the case where each of them is administered alone. all right.

[Example 2] Using a guinea pig wound model system, the following 1) to 3) test substances were compared for their collagen synthesis promoting effects. The base in which each test substance was dissolved was purified water containing 20% ethanol and 3% propylene glycol.

1) 2% Ascorbic acid-2-phosphate sodium salt 2) 1% Ascorbic acid-2-phosphate-6-
Palmitate sodium salt 3) 1% Ascorbic acid-2-phosphate sodium salt, 0.5% Ascorbic acid-2-phosphate ester-6-palmitate sodium salt

Two 2 cm incisions were created symmetrically around the back of the guinea pig, and 0.2 ml of the test substance solution was administered twice a day for 4 days. After the final administration, the skin was excised in a 2 cm square centering on the incised portion, and the tension required for peeling the incised surface was measured. Five guinea pigs were used for one test substance.

The cut portion of the skin after the tension measurement was taken from the cross section 5
mm width and homogenized in 0.5 M acetic acid. Diethyl ether-ethanol (volume ratio 1: 3) was added to the homogenate solution in a volume of 2 times, the mixture was stirred and mixed, and the solvent layer was removed after centrifugation. Add pepsin here and add 16 at 15 ℃
After reacting for a time and centrifuging, the supernatant was freeze-dried. The protein component of the skin thus obtained was hydrolyzed with hydrochloric acid and analyzed for amino acids.

The peeling tension and the hydroxyproline content of the cut portion coated with each test substance were as follows. Hydroxyproline is a substance that serves as an index for collagen.

[0066]           Peeling tension Hydroxyproline content         (G / cm) (nmol / wet weight of skin) 1) 123 5.1 2) 181 7.0 3) 208 9.0

Ascorbic acid-2-phosphate sodium salt and ascorbic acid-2-phosphate-6-
When palmitate sodium salt is administered at the same time, it promotes collagen synthesis as compared with the administration of each of them alone,
It was revealed that it has an effect of promoting recovery of the cut surface.

Example 3 The following creams (1) and (2) were prepared, spread on a watch glass, and irradiated with 200 kJ / m ² of ultraviolet rays in an ultraviolet irradiation device. Then, the ascorbic acid-2-phosphate sodium salt and the ascorbic acid-2-phosphate-6-palmitic acid sodium salt in the cream were analyzed by high performance liquid chromatography.

[0069]   Cream (1)   Condensed ricinoleate hexaglyceryl 1.0%   Fine particle titanium oxide 5.0%   2-Octyldodecyl pivalate 8.0%   Tri (caprylic acid / capric acid) glyceryl 3.0%   Methylphenyl polysiloxane 7.0%   Decamethylcyclopentasiloxane 2.0%   Cetanol 2.0%   2-Methylhexyl paramethoxycinnamate 6.0%   4-tert-butyl-4-methoxybenzoylmethane 2.0%   Decaglyceryl monoisostearate 3.0%   Xanthan gum 0.3%   Ascorbic acid-2-phosphate sodium salt 2.0%   Ascorbic acid-2-phosphate-6-palmitic acid sodium salt                                                         2.0%   Adjusted to 100% with purified water

[0070]   Cream (2)   Condensed ricinoleate hexaglyceryl 1.0%   2-Octyldodecyl pivalate 8.0%   Tri (caprylic acid / capric acid) glyceryl 3.0%   Methylphenyl polysiloxane 7.0%   Decamethylcyclopentasiloxane 2.0%   Cetanol 2.0%   Decaglyceryl monoisostearate 3.0%   Xanthan gum 0.3%   Ascorbic acid-2-phosphate sodium salt 2.0%   Ascorbic acid-2-phosphate-6-palmitic acid sodium salt                                                         2.0%   Adjusted to 100% with purified water

The ascorbic acid-2-phosphate sodium salt and ascorbic acid-2-phosphate-6-palmitic acid sodium salt remaining in each cream were as follows. The addition of fine particles of titanium oxide, 2-ethylhexyl para-methoxycinnamate, and 4-tert-butyl-4-methoxybenzoylmethane, which are UV protectors, was added to the ascorbic acid-2-
It was confirmed that it is effective for stabilizing the sodium phosphate salt and the ascorbic acid-2-phosphate-6-palmitate sodium salt.

[0072]                                     Cream (1) Cream (2) Ascorbic acid-2-phosphate sodium salt                                       98.7% 90.1% Ascorbic acid-2-phosphate-6-palmitic acid sodium salt                                       95.6% 87.3%

[Formulation Example 1] Lotion Lotion Ascorbic acid-2-phosphate sodium salt 2.0% Ascorbic acid-2-phosphate-6-palmitic acid sodium salt 2.0% Citric acid 0.016% Citric acid Sodium acid 2.0% 1,3-butylene glycol 3.0% Ethanol 3.0% Adjust the total amount to 100% with purified water (manufacturing method) Dissolve by heating at 50 ° C and cool with stirring 30
Stop stirring at ℃ and let stand.

[0074] [Prescription example 2] cream   Ascorbic acid-2-phosphate sodium salt 2.0%   Ascorbic acid-2-phosphate-6-palmitic acid sodium salt                                                         2.0%   Cetanol 5.0%   Cyclomethicone 4.0%   Cetyl octanoate 4.0%   Trioctanoin 2.0%   Palmityl alcohol 1.0%   Dimethicone 0.3%   Butylene glycol 7.0%   Hydrogenated lecithin 1.0%   Polyglyceryl myristate-10 1.0%   Sodium citrate 2.0%   Methylparaben 0.15%   Propylparaben 0.05%   Xanthan gum 0.1%   Adjusted to 100% with purified water

(Production Method) 80% excluding ascorbic acid-2-phosphate sodium salt and ascorbic acid-2-phosphate-6-palmitic acid sodium salt
Dissolve by heating at 0 ° C, cool with stirring, and gradually add ascorbic acid-2-phosphate sodium salt and ascorbic acid-2-phosphate-6-palmitic acid sodium salt at 50 ° C. Stop stirring at ℃ and let stand.

[0076] [Prescription example 3] Emulsion   Ascorbic acid-2-phosphate sodium salt 2.0%   Ascorbic acid-2-phosphate-6-palmitic acid sodium salt                                                         2.0%   Glycerin 8.0%   Butylene glycol 2.0%   Hydrogenated lecithin 0.1%   Sodium hyaluronate 0.05%   Hydroxyethyl cellulose 0.3%   Xanthan gum 0.3%   Sodium citrate 1.0%   Polyethylene glycol-50 Hydrogenated castor oil 0.5%   Methylparaben 0.2%   Adjusted to 100% with purified water

(Production Method) 80% excluding ascorbic acid-2-phosphate sodium salt and ascorbic acid-2-phosphate-6-palmitic acid sodium salt
Dissolve by heating at 0 ° C, cool with stirring, slowly add ascorbic acid-2-phosphate sodium salt and ascorbic acid-2-phosphate-6-palmitic acid sodium salt at 50 ° C, and add 40-35. Stop stirring at ℃ and let stand.

[0078]

EFFECTS OF THE INVENTION The cosmetic for preventing wrinkles of the present invention has an excellent effect of promoting collagen synthesis and an effect of suppressing collagen degradation, and can prevent / improve morphological changes due to aging of the skin. It can be widely applied to external products and cosmetics.

─────────────────────────────────────────────────── ─── Continuation of front page (51) Int.Cl. ⁷ Identification code FI theme code (reference) A61K 31/665 A61K 31/665 A61P 17/16 A61P 17/16 43/00 43/00 (72) Inventor Toshi Tsuzuki, 1-1 1-1 Onodai, Midori-ku, Chiba-shi, Chiba Showa Denko Co., Ltd. Research Institute F-term (reference) 4C083 AB242 AC012 AC072 AC102 AC122 AC211 AC212 AC311 AC341 AC342 AC352 AC422 AC432 AC482 AC851 AC902 AD152 AD172 AD282 AD332 AD352 AD572 AD641 AD642 BB46 CC02 CC04 CC05 DD23 DD27 DD31 EE12 4C086 AA01 AA02 DA37 MA02 MA04 MA16 MA22 MA28 MA63 NA14 ZA89 ZC41

Claims (10)

[Claims] (A) The following general formula (1): An ascorbic acid-2-phosphate ester and / or salt thereof represented by: and (b) the following general formula (2): (Wherein R represents an acyl group of a higher fatty acid), a higher fatty acid ester of ascorbic acid-2-phosphate ester and / or a salt thereof are also contained together, and a cosmetic for preventing wrinkles. . 2. The cosmetic for preventing wrinkles according to claim 1, wherein the salt of ascorbic acid-2-phosphate ester is a sodium salt, a potassium salt, a magnesium salt or a zinc salt. 3. The following general formula (2): In the formula (wherein R represents an acyl group of a higher fatty acid), R is lauric acid, myristic acid, palmitic acid or stearic acid, and the anti-wrinkle cosmetic according to claim 1 or 2, Fee. 4. A salt of higher fatty acid ester of ascorbic acid-2-phosphate ester is sodium salt, potassium salt,
The wrinkle-preventing cosmetic material according to any one of claims 1 to 3, which is a magnesium salt or a zinc salt. 5. The wrinkle-preventing cosmetic composition according to claim 1, which further comprises an ultraviolet protection agent. 6. The cosmetic for preventing wrinkles according to claim 5, wherein at least one selected from the group consisting of organic UV protection agents and inorganic UV protection agents is used as the UV protection agent. 7. The organic UV protection agent is one or more selected from the group consisting of benzoic acid ester-based, salicylic acid-based, cinnamic acid-based, urocanic acid-based, benzophenone-based and oxybenzone-based UV protection agents. The wrinkle-preventing cosmetic composition according to claim 6. 8. The cosmetic for preventing wrinkles according to any one of claims 1 to 7, which has a collagen synthesis promoting action. 9. The effect of promoting collagen synthesis is obtained by measuring the content of hydroxyproline in skin tissue by an amino acid analysis method,
The wrinkle-preventing cosmetic composition according to claim 8, wherein the amount of hydroxyproline in the test group is 1.2 to 2 times that of the control group when used as an index of the collagen synthesis promoting effect. 10. The cosmetic for preventing wrinkles according to claim 1, which has a wrinkle suppressing effect.