JP2005336156A - Skin preparation for external use comprising salt of ascorbic acid derivative, stabilizing method of skin preparation for external use, and stabilizer - Google Patents

Abstract

<P>PROBLEM TO BE SOLVED: To provide a stabilizing method of a skin preparation for external use comprising a salt of a higher fatty acid ester of ascorbic acid-2-phosphate and a stabilizer for the skin preparation for external use. <P>SOLUTION: The skin preparation for external use comprises the salt of the higher fatty acid ester of ascorbic acid-2-phosphate and a polyhydric alcohol. The stabilizing method prevents occurrence of turbidity or precipitation with the lapse of time even when the skin preparation for external use is prepared using the salt of the higher fatty acid ester of ascorbic acid-2-phosphate, and therefore can be usefully adopted for the general skin preparation for external use including cosmetics. <P>COPYRIGHT: (C)2006,JPO&NCIPI

Description

  The present invention relates to an ascorbic acid derivative represented by the following general formula (1)

(In the formula, R represents a higher fatty acid residue.)
It is related with the skin external preparation and cosmetics which are excellent in stability containing salt of this.

The present invention also relates to a method for stabilizing an external preparation for skin containing the salt of the ascorbic acid derivative and a stabilizer.

  Ascorbic acid and various derivatives thereof are known as compounds exhibiting effects such as whitening action, antioxidant action, and collagen synthesis promoting action, and are incorporated in pharmaceuticals, cosmetics, feeds and the like.

  In particular, among the ascorbic acid derivatives, the compounds and salts thereof in which the hydroxyl group at the 2-position is converted to a phosphate ester and the hydroxyl group at the 6-position is converted to a higher fatty acid ester are resistant to oxidation and stable and amphiphilic. It has a high affinity and is rapidly transferred to living tissues such as skin, and is expected to be applied to pharmaceuticals, cosmetics, feeds, and the like.

  However, when this higher fatty acid ester salt of ascorbic acid-2-phosphate is formulated as an external preparation for skin, the decomposition occurs in the preparation, and turbidity and precipitation occur over time and the appearance is remarkably impaired. There was a problem that it was.

  Conventionally, skin external preparations for whitening using ascorbic acid or higher fatty acid esters of ascorbic acid in cyclodextrin to improve stability and using polyhydric alcohol as a solvent have been disclosed (see Patent Document 1). However, Patent Document 1 does not describe any skin external preparations using higher fatty acid esters of ascorbic acid-2-phosphate and salts thereof.

  Moreover, the composition for outer_layer | skin which hold | maintains ascorbic acid, its ester derivative, its ether derivative, or those salts in the stable state in the aqueous medium which consists of water and glycol ethers is disclosed (refer patent document 2). However, Patent Document 2 does not describe any topical skin preparation using a salt of a higher fatty acid ester of ascorbic acid-2-phosphate.

  Patent Document 3 discloses a cosmetic material that is stable over time, comprising a water-soluble ascorbic acid derivative such as magnesium ascorbate phosphate, water, and 1,2-alkanediol. However, Patent Document 3 does not describe any topical skin preparation using a salt of a higher fatty acid ester of ascorbic acid-2-phosphate.

  Moreover, the present inventors suppressed decomposition | disassembly in an agent by adjusting the pH to 7-9 in the skin external preparation containing the salt of the higher fatty acid ester of ascorbic acid-2-phosphate ester. An external preparation for skin and cosmetics with improved stability and solubility have already been proposed (see Patent Document 4). In the examples, a lotion containing 10% by mass of propylene glycol in a skin external preparation containing a salt of a higher fatty acid ester of ascorbyl 2-phosphate is disclosed. It has been shown that decomposition of higher fatty acid ester salts of acid esters is inhibited. However, in this lotion, although the decomposition of the salt of the higher fatty acid ester of ascorbic acid-2-phosphate could be suppressed, the occurrence of turbidity could not be suppressed. Therefore, from the practical aspect of a topical skin preparation containing a salt of a higher fatty acid ester of ascorbic acid-2-phosphate, the creation of a topical skin preparation that effectively suppresses the occurrence of turbidity and precipitation over time. Life was still highly sought after.

JP-A-8-113525 JP 2002-348228 A JP 2002-3330 A JP 2003-176217 A

  Therefore, the present invention provides a higher fatty acid ester of ascorbic acid-2-phosphate represented by the following general formula (1) among ascorbic acid derivatives.

(In the formula, R represents a higher fatty acid residue.)
It is an object of the present invention to provide a skin external preparation and a cosmetic with improved stability against turbidity and precipitation over time.

  In addition, the present invention provides a method for stabilizing a skin external preparation containing a salt of a higher fatty acid ester of ascorbic acid-2-phosphate through provision of such a skin external preparation, and a stabilizer for the skin external preparation. It is also an issue to provide.

As a result of intensive studies in view of the above circumstances, the present inventors have made a salt of a higher fatty acid ester of ascorbic acid-2-phosphate and a polyhydric alcohol coexist, preferably a specific amount of a specific polyhydric alcohol. By coexisting, it discovered that the external preparation for skin which effectively suppressed generation | occurrence | production of the turbidity and precipitation with time could be provided, and it came to complete this invention.

  That is, the present invention relates to the following matters.

[1] A skin external preparation characterized by containing a salt of a higher fatty acid ester of ascorbic acid-2-phosphate represented by the following general formula (1) and a polyhydric alcohol;

(Wherein R represents a higher fatty acid residue).
[2] The external preparation for skin according to [1], wherein R in the general formula (1) is a residue of an aliphatic carboxylic acid having 10 to 20 carbon atoms.

  [3] The above [1] or [2], wherein R in the general formula (1) is a residue of lauric acid, myristic acid, palmitic acid, stearic acid, 2-hexyldecanoic acid or isostearic acid The skin external preparation described in 1.

  [4] The external preparation for skin according to any one of [1] to [3], wherein R in the general formula (1) is a residue of palmitic acid.

  [5] The external preparation for skin according to any one of [1] to [3], wherein R in the general formula (1) is a residue of 2-hexyldecanoic acid.

  [6] The salt of higher fatty acid ester of ascorbic acid-2-phosphate is Na salt, K salt, Mg salt or Zn salt, according to any one of [1] to [5], The skin external preparation as described.

  [7] The salt of higher fatty acid ester of the ascorbic acid-2-phosphate ester is contained in an amount of 0.01 to 20% by mass, according to any one of the above [1] to [6] Skin external preparation.

  [8] The polyhydric alcohol is a dihydric alcohol having 5 or 6 carbon atoms (provided that if the number of carbon atoms is 5 or 6, a heteroatom may be inserted in the carbon chain). The external preparation for skin according to any one of the above [1] to [7].

[9] The dihydric alcohol having 5 or 6 carbon atoms is triethylene glycol, dipropylene glycol, 3-methyl-1,3-butanediol, 1,2-pentanediol, 1,4-pentanediol, 1 , 5-pentanediol, 2,4-pentanediol,
2-methyl-2,4-pentanediol, 3-methyl-1,5-pentanediol, 1,
The external preparation for skin according to [8] above, which is at least one selected from the group consisting of 2-hexanediol and 1,6-hexanediol.

  [10] The skin according to [8] or [9], wherein the dihydric alcohol having 5 or 6 carbon atoms is contained in an amount of 0.05% by mass or more and less than 12% by mass. Topical agent.

  [11] The polyhydric alcohol is a divalent or higher alcohol having 2, 3, 4 or 7 carbon atoms (provided that a heteroatom is inserted in the carbon chain if the number of carbon atoms is 3, 4 or 7 or higher) The external preparation for skin according to any one of [1] to [7] above, wherein the alcohol is contained in an amount of 12 to 90% by mass.

  [12] Divalent or higher alcohol having 2, 3, 4 or 7 carbon atoms (provided that the number of carbon atoms is 3, 4 or 7 or more, a heteroatom may be inserted in the carbon chain) .) Is at least one selected from the group consisting of ethylene glycol, propylene glycol, glycerin, 1,3-butanediol, diethylene glycol, polyethylene glycol, polypropylene glycol and polyglycerin [11] The skin external preparation described in 1.

  [13] The external preparation for skin according to any one of [1] to [12], wherein water is contained.

  [14] A cosmetic comprising the external preparation for skin according to any one of [1] to [13].

  [15] A method for stabilizing a skin external preparation containing a salt of a higher fatty acid ester of ascorbic acid-2-phosphate represented by the following general formula (1), characterized by using a polyhydric alcohol;

(Wherein R represents a higher fatty acid residue).

  [16] The polyhydric alcohol is a dihydric alcohol having 5 or 6 carbon atoms (provided that if the number of carbon atoms is 5 or 6, a heteroatom may be inserted in the carbon chain). The method for stabilizing an external preparation for skin according to [15] above, wherein

[17] A stabilizer for external preparations for skin containing a salt of a higher fatty acid ester of ascorbic acid-2-phosphate represented by the following general formula (1), comprising a polyhydric alcohol;

(Wherein R represents a higher fatty acid residue).

  [18] The polyhydric alcohol is a dihydric alcohol having 5 or 6 carbon atoms (provided that if the number of carbon atoms is 5 or 6, a heteroatom may be inserted in the carbon chain). The stabilizer for external preparations for skin described in [17] above.

  According to the present invention, even when a salt of a higher fatty acid ester of ascorbic acid-2-phosphate is formulated as a skin external preparation, it is possible to prevent the occurrence of turbidity and precipitation over time, and to improve stability. Can do. Therefore, the present invention is useful for all external preparations for skin, and particularly useful for cosmetics.

  Hereinafter, the present invention will be specifically described.

<(A) Salt of higher fatty acid ester of ascorbic acid-2-phosphate>
First, the salt of the higher fatty acid ester of ascorbic acid-2-phosphate used in the present invention will be described.

  A higher fatty acid ester of ascorbic acid-2-phosphate serving as a base of the salt is a compound represented by the general formula (1). In the general formula (1), R is a higher fatty acid residue, that is, an acyl group derived from a higher fatty acid, and examples of the higher fatty acid include aliphatic carboxylic acids having 10 to 20 carbon atoms. Specifically, lauric acid, myristic acid, palmitic acid, stearic acid, 2-hexyldecanoic acid, isostearic acid and the like can be preferably mentioned. Of these, palmitic acid and 2-hexyldecanoic acid are more preferable.

  The salt of higher fatty acid ester of ascorbic acid-2-phosphate used in the present invention is such a higher fatty acid ester of ascorbic acid-2-phosphate, that is, phosphoric acid at the hydroxyl group at the 2-position of ascorbic acid. Is preferably a compound in which a phosphate residue and a base constituting a phosphate ester bond at the 2-position of a compound in which a higher fatty acid is ester-bonded to a hydroxyl group at the 6-position form a salt.

Specific examples of salts of higher fatty acid esters of ascorbic acid-2-phosphate include Na salts, K salts, Ca salts, Mg salts, and Zn salts. Among these, Na salts are preferable. Is more preferable. In the present invention, the salt of higher fatty acid ester of ascorbic acid-2-phosphate may be used alone or in combination of two or more.

  In the present invention, the salt of the higher fatty acid ester of ascorbic acid-2-phosphate is generally 0.01 to 20% by mass, preferably 0.05 to 12% by mass, more preferably 0.00% in the total amount of the external preparation for skin. It mix | blends so that it may be contained in the quantity of 2-10 mass%. In such an amount, when a salt of a higher fatty acid ester of ascorbic acid-2-phosphate is contained in the external preparation for skin, the transition to the skin is quick and the efficacy effect required for the external preparation for skin is demonstrated. This is preferable because it is possible.

<(B) Polyhydric alcohol>
In the present specification, the polyhydric alcohol means an alcohol having two or more hydroxyl groups in the molecule, and is a dihydric alcohol, a trihydric alcohol, an ether of a trihydric alcohol, a sugar alcohol, a monosaccharide, or an oligosaccharide. (2-10 sugars) and the like.

  Specific examples of the polyhydric alcohol include ethylene glycol, propylene glycol, 1,3-butanediol, 3-methyl-1,3-butanediol, 1,2-pentanediol, and 1,4-pentane. Diol, 1,5-pentanediol, 2,4-pentanediol, 2-methyl-2,4-pentanediol, 3-methyl-1,5-pentanediol, 1,2-hexanediol, 1,6-hexane Dihydric alcohols such as diol, diethylene glycol, triethylene glycol, polyethylene glycol, dipropylene glycol, and polypropylene glycol; trihydric alcohols such as glycerin; ethers of trihydric alcohols such as diglycerin and polyglycerin; mannitol, sorbitol, xylitol, maltitol , Erythritol, sugar alcohols such as pentaerythritol; glucose, fructose, monosaccharides such as xylose, sucrose, lactose, maltose, oligosaccharides, and the like, such as trehalose.

Of these, one of the preferred examples is a dihydric alcohol having 5 or 6 carbon atoms. The carbon chain constituting the dihydric alcohol may be branched, and if the number of carbon atoms is 5 or 6, a heteroatom may be inserted in the carbon chain. That is, the dihydric alcohol only needs to have a total of 5 or 6 carbon atoms, and the carbon chain constituted by these carbon atoms is an intermittent carbon having a hetero atom between carbon atoms. It may be a chain.

That is, a hetero atom may be sandwiched in the middle of the carbon chain constituting the dihydric alcohol, and examples of the hetero atom include oxygen, nitrogen, sulfur and the like.
Specific examples of the dihydric alcohol having 5 or 6 carbon atoms include, for example, triethylene glycol, dipropylene glycol, 3-methyl-1,3-butanediol, 1,2-pentanediol, 1,4 -Pentanediol, 1,5-pentanediol, 2,4-pentanediol, 2-methyl-2,4-pentanediol, 3-methyl-1,5-pentanediol, 1,2-hexanediol, 1,6- Examples include hexanediol.

  Of these, 1,2-pentanediol, 1,4-pentanediol, 1,5-pentanediol, 2,4-pentanediol, 1,2-hexanediol, and 1,6-hexanediol are preferable. More preferred are 1,2-pentanediol and 1,2-hexanediol.

These dihydric alcohols having 5 or 6 carbon atoms may be used alone or in combination of two or more.
In the external preparation for skin of the present invention, the dihydric alcohol having 5 or 6 carbon atoms may be blended in an amount suitable for suppressing the turbidity and precipitation of the obtained external preparation for skin. The total amount of the external preparation for skin is usually contained in an amount of 0.05% by mass or more and less than 12% by mass, preferably 0.5 to 11% by mass, more preferably 0.5 to 10% by mass. .

  When a specific dihydric alcohol is used in this way, the amount used can be suppressed to an amount within the above range, and the use of an external preparation for skin obtained as compared with the use of other polyhydric alcohols The feeling is good.

  Another preferred example is a divalent or higher alcohol having 2, 3, 4 or 7 or more carbon atoms. The carbon chain constituting the alcohol may be branched. If the number of carbon atoms is 3, 4 or 7 or more, a heteroatom may be inserted in the carbon chain. That is, the alcohol may have a total of 2, 3, 4 or 7 or more carbon atoms. When the total number of carbon atoms is 3, 4 or 7 or more, the alcohol is constituted by these carbon atoms. The carbon chain to be formed may be an intermittent carbon chain having a hetero atom between carbon atoms.

That is, a hetero atom may be interposed in the middle of the carbon chain constituting the alcohol, and examples of the hetero atom include oxygen, nitrogen, sulfur and the like.
Specific examples of the divalent or higher alcohol having 2, 3, 4 or 7 or more carbon atoms include, for example, ethylene glycol, propylene glycol, glycerin, 1,3-butanediol, diethylene glycol, polyethylene glycol, and polypropylene glycol. And polyglycerin.

  Of these, propylene glycol, glycerin, 1,3-butanediol, diethylene glycol, polyethylene glycol, and polyglycerin are preferable, and propylene glycol and 1,3-butanediol are more preferable.

  These divalent or higher alcohols having 2, 3, 4 or 7 or more carbon atoms may be used alone or in combination of two or more.

  The blending amount of the divalent or higher alcohol having 2, 3, 4 or 7 or more carbon atoms may be an amount suitable for suppressing the occurrence of turbidity and precipitation of the obtained external preparation for skin. Specifically, The total amount of the external preparation for skin needs to be 12 to 90% by mass, preferably 15 to 90% by mass, more preferably 20 to 90% by mass. When 12 to 90% by mass of a divalent or higher alcohol having 2, 3, 4 or 7 or more carbon atoms is contained, it effectively suppresses the occurrence of turbidity and precipitation over time of the obtained external preparation for skin. it can. On the other hand, when the amount is less than 12% by mass, the occurrence of turbidity and precipitation may not be sufficiently suppressed. Even when the amount is more than 90% by mass, the occurrence of turbidity and precipitation is sufficiently suppressed. It may not be possible and is not preferable.

  In addition, the density | concentration in the skin external preparation of a polyhydric alcohol can be measured by general methods, such as the determination method using a gas chromatography.

<(C) Other ingredients>
In addition to the above-mentioned salts of higher fatty acid esters of ascorbic acid-2-phosphate and polyhydric alcohols, components generally used for skin external preparations can be blended in the external preparation for skin of the present invention.

Examples of such components include ozokerite, α-olefin oligomer, light isoparaffin, light liquid isoparaffin, squalene, squalane, synthetic squalane, plant squalane, ceresin, paraffin, polyethylene powder, polybutene, microcrystalline wax, liquid isoparaffin, Hydrocarbons such as liquid paraffin, mineral oil, petrolatum;

  Jojoba oil, carnauba wax, candelilla wax, rice bran wax, shellac, lanolin, mink sebum wax, whale wax, sugar cane wax, sperm whale oil, beeswax, montan wax and other natural waxes, avocado oil, almond oil, olive oil, extra virgin olive oil, Sesame oil, rice bran oil, rice oil, rice germ oil, corn oil, safflower oil, soybean oil, corn oil, rapeseed oil, persic oil, palm kernel oil, palm oil, castor oil, sunflower oil, high oleic sunflower oil, Grape seed oil, cottonseed oil, palm oil, hydrogenated palm oil, beef tallow, hardened oil, horse oil, mink oil, egg yolk oil, egg yolk fat oil, rosehip oil, cucumber nut oil, evening primrose oil, wheat germ oil, peanut oil, camellia oil Oil, sasanqua oil, cacao butter, owl, beef bone fat, beef leg oil, pork fat, horse fat, sheep fat, sheabata , Macadamia nut oil, natural fats and oils of meadowfoam oil, and the like;

Fatty acids such as lauric acid, myristic acid, palmitic acid, stearic acid, behenic acid, oleic acid, linoleic acid, linolenic acid, γ-linolenic acid, isostearic acid, 12-hydroxystearic acid, undecylenic acid, coconut oil fatty acid;
Higher monoalcohols such as isostearyl alcohol, octyldodecanol, hexyldecanol, cholesterol, phytosterol, lauryl alcohol, myristyl alcohol, cetanol, stearyl alcohol, oleyl alcohol, behenyl alcohol, cetostearyl alcohol;

  Alkyl glyceryl ethers such as batyl alcohol, chimyl alcohol, ceralkyl alcohol, isostearyl glyceryl ether;

  Isopropyl myristate, butyl myristate, isopropyl palmitate, ethyl stearate, butyl stearate, ethyl oleate, ethyl linoleate, isopropyl linoleate, cetyl caprylate, hexyl laurate, isooctyl myristate, decyl myristate, myristic acid Myristyl, cetyl myristate, octadecyl myristate, cetyl palmitate, stearyl stearate, decyl oleate, oleyl oleate, cetyl ricinoleate, isostearyl laurate, isotridecyl myristate, isocetyl myristate, isostearyl myristate, myristic acid Octyldodecyl, 2-ethylhexyl palmitate, isocetyl palmitate, isostearyl palmitate, 2-ethyl stearate Ruhexyl, isocetyl stearate, isodecyl oleate, octyldodecyl oleate, octyldodecyl ricinoleate, ethyl isostearate, isopropyl isostearate, cetyl 2-ethylhexanoate, cetostearyl 2-ethylhexanoate, stearyl 2-ethylhexanoate, Hexyl isostearate,

Ethylene glycol dioctanoate, ethylene glycol dioleate, propylene glycol dicaprylate, di (capryl / capric) propylene glycol, propylene glycol dicaprate, propylene glycol dioleate, neopentyl glycol dicaprate, neopentyl glycol dioctanoate, glyceryl tricaprylate Glyceryl tri-2-ethylhexanoate, glyceryl tri (capryl / capric acid), glyceryl tri (caprylic acid / capric acid / stearic acid), glyceryl triundecylate, glyceryl triisopalmitate, glyceryl triisostearate, tri-2-ethyl Hexanoic acid trimethylolpropane, triisostearic acid trimethylolpropane, tetra 2-ethylhexanoic acid pentaerythrityl Tetra myristate pentaerythrityl tetra isostearate pentaerythrityl, diglyceryl tetra isostearate, octyldodecyl neopentanoate, isocetyl octanoate, isostearyl octanoate,

2-ethylhexyl isoperargonate, hexyldecyl dimethyloctanoate, octyldodecyl dimethyloctanoate, 2-ethylhexyl isopalmitate, isocetyl isostearate, isostearyl isostearate, octyldodecyl isostearate, lauryl lactate, myristyl lactate, cetyl lactate, Octyldodecyl lactate, triethyl citrate, acetyl triethyl citrate, acetyl tributyl citrate, trioctyl citrate, triisocetyl citrate, trioctyl dodecyl citrate, diisostearyl malate, 2-ethylhexyl hydroxystearate, di-2-succinate Ethylhexyl, diisopropyl adipate, diisobutyl adipate, dioctyl adipate, diheptyl undecyl adipate, disebacate Chill, diisopropyl sebacate, dioctyl sebacate, cholesteryl stearate, cholesteryl isostearate, cholesteryl hydroxystearate, cholesteryl oleate, dihydrocholesteryl oleate, phytosteryl isostearate, phytosteryl oleate, isocetyl 12-stearoylhydroxystearate, 12- Stearoyl hydroxy stearate stearyl, 12-stearoyl hydroxy stearate isostearyl acetate, polyoxyethylene (3) polyoxypropylene (1) cetyl ether, polyoxyethylene acetate (3) polyoxypropylene (1) isocetyl ether, isononanoic acid Such as isononyl, octyl isononanoate, tridecyl isononanoate, isotridecyl isononanoate Ester compounds;

  Methylpolysiloxane, methylphenylpolysiloxane, methylhydrogenpolysiloxane, methylcyclopolysiloxane, octamethylcyclotetrasiloxane, decamethylcyclopentasiloxane, dodecamethylcyclohexasiloxane, octamethyltrisiloxane, decamethyltetrasiloxane, tetradeca Methyl hexasiloxane, highly polymerized methyl polysiloxane, dimethyl siloxane methyl (polyoxyethylene) siloxane methyl (polyoxypropylene) siloxane copolymer, dimethyl siloxane methyl (polyoxyethylene) siloxane copolymer, dimethyl siloxane methyl (Polyoxypropylene) siloxane copolymer, dimethylsiloxane / methylcetyloxysiloxane copolymer, dimethylsiloxane / Chill stearoxysiloxane copolymer, polyether-modified silicones, alcohol-modified silicones, alkyl-modified silicones, silicone oils such as amino-modified silicone;

  Sodium alginate, carrageenan, agar, fur celerin, guar gum, quince seed, konjac mannan, tamarind gum, tara gum, dextrin, starch, locust bean gum, gum arabic, gati gum, karaya gum, tragacanth gum, arabinogalactan, pectin, quince, chitosan, card Orchid, xanthan gum, gellan gum, cyclodextrin, dextran, pullulan, microcrystalline cellulose, methylcellulose, ethylcellulose, hydroxyethylcellulose, hydroxypropylcellulose, hydroxypropylmethylcellulose, carboxymethylcellulose, carboxystarch, cationized cellulose, starch phosphate ester, cationized guar gum , Carboxymethyl hydroxyp Pills guar gum, hydroxypropylated guar gum, albumin, casein, gelatin, sodium polyacrylate, polyacrylic acid amide, carboxyvinyl polymers, polyethylene imine,

Highly polymerized polyethylene glycol, polyvinyl alcohol, polyvinyl pyrrolidone, polyvinyl ether, polyacrylamide, acrylic acid polymer, methacrylic acid polymer, maleic acid polymer, vinyl pyridine polymer, ethylene / acrylic acid copolymer, vinyl pyrrolidone polymer, Vinyl alcohol / vinyl pyrrolidone copolymer, nitrogen-substituted acrylamide polymer, amino-modified silicone, cationized polymer, dimethylacrylammonium polymer, acrylic acid-based anion polymer, methacrylic acid-based anion polymer, modified silicone, alkyl methacrylate ( C ₁₀ ~ ₃₀₎ copolymers, polyoxyethylene /
Macromolecules such as polyoxypropylene copolymer;
Monoalcohols such as ethanol, isopropyl alcohol, 1-butanol, 2-butanol, benzyl alcohol;

  Palm oil fatty acid potassium, coconut oil fatty acid sodium, coconut oil fatty acid triethanolamine, potassium laurate, sodium laurate, triethanolamine laurate, potassium myristate, sodium myristate, isopropanolamine myristate, potassium palmitate, palmitic acid Sodium, isopropanolamine palmitate, potassium stearate, sodium stearate, triethanolamine stearate, potassium oleate, sodium oleate, castor oil fatty acid sodium, zinc undecylenate, zinc laurate, zinc myristate, magnesium myristate, Zinc palmitate, zinc stearate, calcium stearate, magnesium stearate, aluminum stearate, myristi Calcium oxide, magnesium myristate, aluminum dimyristate, aluminum isostearate, polyoxyethylene lauryl ether acetic acid, sodium polyoxyethylene lauryl ether acetate, polyoxyethylene tridecyl ether acetic acid, sodium polyoxyethylene tridecyl ether acetate, stearoyl lactic acid Sodium, sodium isostearoyl lactate, sodium lauroyl sarcosine, coconut oil fatty acid sarcosine, coconut oil fatty acid sarcosine sodium, coconut oil fatty acid sarcosine triethanolamine,

Lauroyl sarcosine, lauroyl sarcosine potassium, lauroyl sarcosine triethanolamine, oleoyl sarcosine, sodium myristoyl sarcosine, sodium stearoyl glutamate, coconut oil fatty acid acyl glutamate, coconut oil fatty acid acyl glutamate potassium, coconut oil fatty acid acyl glutamate sodium, coconut oil fatty acid acyl glutamate Triethanolamine, lauroyl acylglutamate, potassium lauroyl acylglutamate, sodium lauroyl acylglutamate, triethanolamine lauroylacylglutamate, myristoylacylglutamic acid, potassium myristoylacylglutamate, myristoylacylglutamate sodium, stearoylacylglutamic acid, stearoy Potassium acyl glutamate, disodium stearoyl acyl glutamate, hardened tallow fatty acid sodium acyl glutamate, coconut oil fatty acid / hardened tallow fatty acid sodium acyl glutamate, coconut oil fatty acid sodium methylalanine, lauroylmethylalanine, lauroylmethylalanine sodium, lauroylmethylalanine triethanolamine , Sodium myristoylmethylalanine, sodium lauroylmethyltaurine,

Palm oil fatty acid methyl taurine potassium, coconut oil fatty acid methyl taurine sodium, palm oil fatty acid methyl taurine magnesium, myristoyl methyl taurine sodium, palmitoyl methyl taurine sodium, stearoyl methyl taurine sodium, oleoyl methyl taurine sodium, sodium alkane sulfonate, tetradecene sulfone Sodium sulfate, dioctyl sodium sulfosuccinate, disodium lauryl sulfosuccinate, sodium coconut oil fatty acid ethyl ester sulfonate, sodium lauryl sulfate, lauryl sulfate triethanolamine, sodium cetyl sulfate, alkyl (11,13,15) triethanolamine sulfate, Alkyl (12,13) sodium sulfate, alkyl (12,13) triethanolamine sulfate, alkyl (1 , 14, 16) sulfate, alkyl (12-13) diethanolamine sulfate, alkyl (12-14) sulfate, triethanolamine alkyl (
12-15) Triethanolamine sulfate,

Coconut oil alkyl magnesium sulfate / triethanolamine, ammonium lauryl sulfate, potassium lauryl sulfate, magnesium lauryl sulfate, monoethanolamine lauryl sulfate, diethanolamine lauryl sulfate, sodium myristyl sulfate, sodium stearyl sulfate, sodium oleyl sulfate, triethanolamine oleyl sulfate, poly Sodium oxyethylene lauryl ether sulfate, polyoxyethylene lauryl ether sulfate triethanolamine, polyoxyethylene (1) alkyl (11,13,15) ether sodium sulfate, polyoxyethylene (1) alkyl (11,13,15) ether Triethanolamine sulfate, polyoxyethylene (3) alkyl (11-15) ether sodium sulfate, polyoxyethylene ( ) Alkyl (12,13) ether sodium sulfate, polyoxyethylene (3) alkyl (12-14) sodium ether sulfate, polyoxyethylene (3) alkyl (12-15) sodium ether sulfate, polyoxyethylene (2) lauryl Sodium ether sulfate, polyoxyethylene (3) sodium myristyl ether sulfate,

Higher fatty acid alkanolamide sulfate sodium ester, lauryl phosphate, sodium lauryl phosphate, potassium cetyl phosphate, diethanolamine cetyl phosphate, polyoxyethylene oleyl ether phosphate, polyoxyethylene lauryl ether phosphate, sodium polyoxyethylene lauryl ether phosphate, Polyoxyethylene cetyl ether phosphate, sodium polyoxyethylene cetyl ether phosphate, polyoxyethylene stearyl ether phosphate, sodium polyoxyethylene oleyl ether phosphate, polyoxyethylene alkylphenyl ether phosphate, polyoxyethylene alkylphenyl ether phosphate Acid sodium, polyoxyethylene alkyl phenyl ether triethanolamine phosphate, polyoxyethylene Octyl ether phosphate, polyoxyethylene (10) alkyl (12,13) ether phosphate, polyoxyethylene alkyl (12-15) ether phosphate, polyoxyethylene alkyl (12-16) ether phosphate, polyoxyethylene Anionic surfactants such as lauryl ether phosphate triethanolamine and polyoxyethylene oleyl ether phosphate diethanolamine;

Dioctylamine, dimethylstearylamine, trilaurylamine, diethylaminoethylamide stearate, lauryltrimethylammonium chloride, cetyltrimethylammonium chloride, cetyltrimethylammonium bromide, cetyltrimethylammonium saccharin, stearyltrimethylammonium chloride, alkyl chloride (20-22) Trimethylammonium, lauryltrimethylammonium bromide, alkyl (16,18) trimethylammonium chloride, stearyltrimethylammonium bromide, stearyltrimethylammonium saccharin, alkyl (28) trimethylammonium chloride, di (polyoxyethylene) oleylmethylammonium chloride (2EO) ), Dipolyoxyethylene stearylmethylammonium chloride Polyoxyethylene chloride (1) polyoxypropylene (
25) Diethylmethylammonium chloride, tri (polyoxyethylene) stearylammonium chloride (5EO), distearyldimethylammonium chloride, dialkyl (12-15) dimethylammonium chloride, dialkyl (12-18) dimethylammonium chloride, dialkylchloride (14- 18) Dimethyl ammonium, dicocoyl dimethyl ammonium chloride, dicetyl dimethyl ammonium chloride, isostearyl lauryl dimethyl ammonium chloride, benzalkonium chloride, myristyl dimethyl benzyl ammonium chloride, lauryl dimethyl (ethyl benzyl) ammonium chloride, stearyl dimethyl benzyl ammonium chloride, Laurylpyridinium chloride, cetylpyridinium chloride, lauroylcholaminoformylmethylpyridinium chloride, salt Cationic surfactants such as stearoylcoraminoformylmethylpyridinium bromide, alkylisoquinolium bromide, methylbenzethonium chloride, benzethonium chloride;

2-alkyl-N-carboxymethyl-N-hydroxyethylimidazolinium betaine, alkyldiaminoethylglycine hydrochloride, sodium lauryldiaminoethylglycine, undecylhydroxyethylimidazolium betaine sodium, undecyl-N-carboxymethylimidazolium betaine Coconut oil fatty acid acyl-N-carboxyethyl-N-hydroxyethylethylenediamine disodium, coconut oil fatty acid acyl-N-carboxyethoxyethyl-N-carboxyethylethylenediamine disodium, coconut oil fatty acid acyl-N-carboxymethoxyethyl-N -Carboxymethylethylenediamine disodium, sodium laurylaminopropionate, sodium laurylaminodipropionate, laurylaminopropyl Triethanolamine pionate, palm oil fatty acid acyl-N-carboxyethyl-N-hydroxyethylethylenediamine sodium, lauryl dimethylaminoacetic acid betaine, coconut oil alkyldimethylaminoacetic acid betaine, stearyldimethylaminoacetic acid betaine, stearyldimethylbetaine sodium, coconut oil Amphoteric surfactants such as fatty acid amidopropyl betaine, palm oil fatty acid amidopropyl betaine, lauric acid amidopropyl acetic acid betaine, ricinoleic acid amidopropyl betaine, stearyl dihydroxyethyl betaine, lauryl hydroxysulfo betaine;

  Polyoxyethylene (10) alkyl (12,13) ether, polyoxyethylene lauryl ether, polyoxyethylene cetyl ether, polyoxyethylene stearyl ether, polyoxyethylene oleyl ether, polyoxyethylene (3, 7, 12) alkyl ( 12-14) ether, polyoxyethylene tridecyl ether, polyoxyethylene myristyl ether, polyoxyethylene-sec-alkyl (14) ether, polyoxyethylene isocetyl ether, polyoxyethylene cetostearyl ether, polyoxyethylene (2 , 10, 20) Isostearyl ether, polyoxyethylene oleyl cetyl ether, polyoxyethylene (20) aralkyl ether, polyoxyethylene octyldodecyl ether Polyoxyethylene behenyl ether, polyoxyethylene octyl phenyl ether, polyoxyethylene nonyl phenyl ether, polyoxyethylene dinonyl phenyl ether, polyoxyethylene (1) polyoxypropylene (1,2,4,8) cetyl ether, poly Oxyethylene (5) polyoxypropylene (1,2,4,8) cetyl ether, polyoxyethylene (10) polyoxypropylene (1,2,4,8) cetyl ether, polyoxyethylene (20) polyoxypropylene (1,2,4,8) cetyl ether, polyoxyethylene polyoxypropylene lauryl ether, polyoxyethylene (3) polyoxypropylene (34) stearyl ether, polyoxyethylene (4) polyoxypropylene (30) Allyl ether, polyoxyethylene (34) polyoxypropylene (23) stearyl ether, polyoxyethylene polyoxypropylene cetyl ether, polyoxyethylene polyoxypropylene decyl tetradecyl ether,

Polyethylene glycol monolaurate, ethylene glycol monostearate, polyethylene glycol monostearate, polyethylene glycol monooleate, ethylene glycol fatty acid ester, self-emulsifying ethylene glycol monostearate, diethylene glycol laurate, polyethylene glycol myristate, polyethylene glycol palmitate , Diethylene glycol stearate, self-emulsifying polyethylene glycol monostearate (2), polyethylene glycol isostearate, ethylene glycol dioctanoate, diethylene glycol dilaurate, polyethylene glycol dilaurate, polyethylene glycol dipalmitate (150), ethylene glycol distearate, Distearic acid Tylene glycol, polyethylene glycol distearate, ethylene glycol dioleate, polyethylene glycol dioleate, polyethylene glycol diricinoleate, polyoxyethylene (20) sorbitan monolaurate, polyoxyethylene (20) sorbitan monopalmitate, polyoxy monostearate Ethylene (6) sorbitan, polyoxyethylene (20) sorbitan monostearate, polyoxyethylene (20) sorbitan tristearate, polyoxyethylene (6) sorbitan monooleate, polyoxyethylene (20) sorbitan monooleate, Polyoxyethylene trioleate (20) sorbitan, polyoxyethylene (20) coconut fatty acid sorbitan, polyoxyethylene monolaurate (10 to 80) sorbitan,
Polyoxyethylene sorbitan tristearate, polyoxyethylene (20) sorbitan isostearate, polyoxyethylene (150) sorbitan tristearate,

Polyoxyethylene castor oil, polyoxyethylene hydrogenated castor oil, polyoxyethylene (10) hydrogenated castor oil, polyoxyethylene (20) hydrogenated castor oil, polyoxyethylene (40) hydrogenated castor oil, polyoxyethylene (50) hydrogenated Castor oil, polyoxyethylene (60) hydrogenated castor oil, lipophilic glyceryl monostearate, lipophilic glyceryl monooleate, glyceryl monostearate, palm oil fatty acid glyceryl, glyceryl laurate, glyceryl myristate, Glyceryl isostearate, glyceryl ricinoleate, glyceryl monohydroxystearate, glyceryl oleate, glyceryl linoleate, glyceryl erucate, glyceryl behenate, wheat germ oil fatty acid glyceride, safflower oil fatty acid glyceryl Hydrogenated soybean fatty acid glyceryl, saturated fatty acid glycerides, cottonseed oil fatty acid glyceryl, monoisostearate monomyristate, mono bovine fatty acid glycerides, mono-lanolin fatty acid glyceryl, sesquioleate, glyceryl distearate, diisostearate, glyceryl Jiarakin glyceryl

Sorbitan monolaurate, sorbitan monopalmitate, sorbitan monostearate, sorbitan monoisostearate, sorbitan monooleate, sorbitan sesquistearate, sorbitan sesquioleate, sorbitan tristearate, sorbitan trioleate, coconut fatty acid sorbitan, isostearin Sorbitan acid, sorbitan sesquiisostearate, sorbitan distearate, diglyceryl isopalmitate, poly (4-10) glyceryl monolaurate, poly (10) glyceryl monomyristate, poly (2-10) glyceryl monostearate, monoisostearate Poly (2-10) glyceryl acid, poly (2-10) glyceryl monooleate, diglyceryl sesquioleate, poly (2) diisostearate 10) Glyceryl, poly (6-10) glyceryl distearate, diglyceryl triisostearate, poly (10) glyceryl tristearate, poly (10) glyceryl trioleate, poly (2) glyceryl tetraisostearate, pentastearic acid Decaglyceryl, poly (6 to 10) glyceryl pentaoleate, poly (10) glyceryl heptearate, decaglyceryl decastearate, poly (10) glyceryl decaoleate, poly (6) glyceryl condensed ricinoleate, sucrose fatty acid ester Coconut oil fatty acid sucrose ester, alkyl glucoside, coconut oil alkyl dimethylamine oxide, lauryl dimethylamine oxide, dihydroxyethyl lauryl dimethylamine oxide, stearyl dimethylamine oxy De, oleyl dimethyl amine oxide, and nonionic surfactants such as polyoxyethylene coconut oil alkyldimethylamine oxide;

  Saponin, lecithin, soybean phospholipid, hydrogenated soybean phospholipid, soybean lysophospholipid, hydrogenated soybean lysophospholipid, egg yolk lecithin, hydrogenated egg yolk lysophosphatidylcholine, phosphatidylcholine, phosphatidylethanolamine, phosphatidylserine, sphingophospholipid, sphingomyelin, ganglioside Natural surfactants such as bile acid, cholic acid, deoxycholic acid, sodium cholate, sodium deoxycholate, spicrispolic acid, rhamnolipid, trehalose lipid, sophorolipid, mannosylerythritol lipid;

Paraaminobenzoic acid, ethyl paraaminobenzoate, glyceryl paraaminobenzoate, amyl paradimethylaminobenzoate, paraaminobenzoic acid derivatives such as 2-ethylhexyl paradimethylaminobenzoate, benzyl cinnamate, diparamethoxycinnamic acid mono-2 -Glyceryl ethylhexanoate, methyl 2,4-diisopropylcinnamate, ethyl 2,4-diisopropylcinnamate, potassium paramethoxycinnamate, sodium paramethoxycinnamate, isopropyl paramethoxycinnamate, paramethoxycinnamate Cinnamic acid derivatives such as 2-ethylhexyl cinnamate, 2-ethoxyethyl paramethoxycinnamate, ethyl paraethoxycinnamate, urocanic acid derivatives such as urocanic acid, ethyl urocanate,

2,4-dihydroxybenzophenone, 2,2 ′, 4,4′-tetrahydroxybenzophenone, sodium 2-hydroxy-4-methoxy-5-sulfobenzophenone, 2-hydroxy-4-methoxybenzophenone-5-sulfonic acid, 2 -Hydroxy-4-methoxybenzophenone, 2,2'-dihydroxy-4,4'-dimethoxybenzophenone, benzophenone derivatives such as sodium 2,2'-dihydroxy-4,4'-dimethoxy-5-sulfobenzophenone, ethylene glycol salicylate , Salicylic acid derivatives such as 2-ethylhexyl salicylate, phenyl salicylate, benzyl salicylate, p-tert-butylphenyl salicylate, homomenthyl salicylate, salicylic acid-3,3,5-trimethylcyclohexyl, 2- ( '- hydroxy-5'-methoxyphenyl) benzotriazole, ultraviolet absorbers such as 4-tert-butyl-4'-methoxybenzoyl methane;

  Kaolin, anhydrous silicic acid, magnesium aluminum silicate, sericite, talc, boron nitride, mica, montmorillonite, hemp cellulose powder, wheat starch, silk powder, corn starch, nitro dye, azo dye, nitroso dye, triphenyl Methane dyes, xanthene dyes, quinoline dyes, anthraquinone dyes, indigo dyes, pyrene dyes, phthalocyanine dyes, flavonoids, quinone, porphyrin, water-soluble anato, squid powder, caramel, guaiazulene, gardenia blue, gardenia yellow , Cochineal, shikonin, copper chlorophyllin sodium, paprika dye, safflower red, safflower yellow, lacqueric acid, riboflavin butyrate, and other natural dyes, carbon black, yellow iron oxide, black iron oxide, red rose, conger, group , Zinc oxide, chromium oxide, titanium oxide, black titanium oxide, zirconium oxide, chromium hydroxide, alumina, magnesium oxide, barium sulfate, aluminum hydroxide, calcium carbonate, lithium cobalt titanate, manganese violet, pearl pigment powder, etc. And coloring materials;

  Ashitaba extract, Acacia extract, Avocado extract, Achacha extract, Achachazul extract, Altea extract, Arnica extract, Oil-soluble Arnica extract, Almond extract, Aloe extract, Anthony extract, Ginkgo biloba extract, Nettle extract, Iris root extract, Fennel extract , Turmeric extract, Ages extract, Echinacea leaf extract, Ogon extract, Oat extract, Prunus extract, Barley extract, Okra extract, Hypericum extract, Oil-soluble Hypericum extract, Adriatic extract , Orange flower water, seaweed extract, oyster tannin, cuckoo extract, valerian extract, cattail extract, chamomile extract, oil-soluble chamomile extract, chamomile Water, oat extract, carrot extract, oil-soluble carrot extract, carrot oil, pearl millet extract, licorice extract, licorice extract powder, licorice flavonoids, cantalis tincture, raspberry extract, kiwi extract, quina extract, cucumber extract, kyonin extract, quince seed extract Gardenia extract, Kumazasa extract, Clara extract, Walnut shell extract, Grapefruit extract, Clematis extract, Brown sugar extract, Chlorella extract, Mulberry extract, Keihi extract,

Gentian extract, Gentian pepper extract, black tea extract, corn plant extract, burdock extract, oil-soluble burdock extract, wheat germ extract, hydrolyzed wheat powder, rice bran extract, rice bran ferment extract, comfrey extract, saicin extract, saffron extract, savon extract, oil Soluble Salvia Extract, Hawthorn Extract, Salamander Extract, Shiitake Extract, Shiitake Extract Powder, Giant Extract, Shikon Extract, Oil-soluble Citrus Extract, Perilla Extract, Linden Extract, Oil-soluble Linden Extract, Citrus Extract, Peonies Extract, Jujudama Extract, Pepper Extract, Oil Soluble Pepper extract, Pepper tincture, Pepper root extract, Birch extract, Oil-soluble birch extract, Birch sap, Honeysuckle extract,
Horse chestnut extract, oil-soluble horsetail extract, scordinin, stevia extract, horseshoe extract, hawthorn extract, horse elder extract, horse chestnut extract, oil yarrow extract, oil soluble yarrow extract, mint extract, sage extract, oil soluble sage extract, Sage water, mallow extract, celery extract, senkyu extract, senkyu water, senbu extract, soybean extract, taisou extract, thyme extract, tea extract, tea dry extract, tea seed extract, clove extract, chimpi extract, camellia extract, camellia extract, oil-soluble teigurumi Extract, Duke extract, Terminaria extract, chili pepper, toki extract, oil-soluble toki extract,

Toki water, Tokin-Senka extract, oil-soluble Toki-Senka extract, soybean milk powder, Tounin extract, Spruce extract, Dokudami extract, Tomato extract, Tormentilla extract, Natto extract, Carrot extract, Oil-soluble carrot extract, Garlic extract, Novara extract, Oil-soluble Novara extract, Bakuga extract, Bakuga root extract, Bakumondo extract, Parsley extract, Hadakamugi leaf juice concentrate, Distilled peppermint water, Hamelis water, Hamelis extract, Rose extract, Parietalia extract, Toad extract, Biwa leaf extract, Oil soluble loquat leaf Extract, dandelion extract, butterfly extract, butcher bloom extract, butcher bloom extract powder, grape extract, grape leaf extract, grape water, hay flower extract, loofah extract, loofah water, safflower extract, oil-soluble body Juice extract, Bodaiju water, Button extract, Hop extract, Oil-soluble hop extract, Pine extract, Maria thistle extract, Maronie extract, Oil-soluble Maronie extract, Mukuroji extract, Melissa extract, Melilot extract, Peach leaf extract, Oil-soluble Peach leaf extract, Prunus Extract, cornflower extract, cornflower water, eucalyptus extract, yukinoshita extract, lily extract, yokoinin extract, oil-soluble yokuinin extract, mugwort extract, mugwort water, lavender extract, lavender water, apple extract, litchi extract, lettuce extract, lemon extract, forsythia extract , Plant extracts such as rose water, rosemary extract, oil-soluble rosemary extract, roman chamomile extract, bitumen extract;

  Glycine, alanine, valine, leucine, isoleucine, serine, threonine, phenylalanine, tyrosine, tryptophan, cystine, cysteine, methionine, proline, hydroxyproline, aspartic acid, asparagine, glutamic acid, glutamine, arginine, histidine, lysine, γ-aminobutyric acid Amino acids and peptides such as DL-pyrrolidonecarboxylic acid, ε-aminocaproic acid, hydrolyzed elastin, water-soluble elastin, hydrolyzed collagen, water-soluble collagen, casein, glutathione, wheat peptide, soybean peptide;

  Vitamin A such as retinol, retinal, retinoic acid, retinol acetate, retinol palmitate, etc., carotenoids such as α-carotene, β-carotene, γ-carotene, δ-carotene, lycopene, zeaxanthin, cryptoxanthine, echinone, astaxanthin, Vitamin B1 such as thiamine, vitamin B2 such as riboflavin, vitamin B6 such as pyridoxine, pyridoxal, pyridoxamine, vitamin B12 such as cyanocobalamin,

Folic acid, nicotinic acid, nicotinic acid amide, pantothenic acid, biotins, L-ascorbic acid, sodium L-ascorbate, L-ascorbyl stearate, L-ascorbyl palmitate, L-ascorbyl dipalmitate, tetraisopalmitic acid Vitamin C such as L-ascorbyl, L-ascorbic acid sulfate disodium, L-ascorbyl magnesium phosphate, sodium L-ascorbyl phosphate, L-ascorbic acid-2-glucoside, ergocalciferol, cholecalciferol, etc. Vitamin E such as vitamin Ds, d-α-tocopherol, DL-α-tocopherol, dl-α-tocopherol acetate, dl-α-tocopherol succinate, β-tocopherol, γ-tocopherol, d-δ-tocopherol, Bikinon acids, vitamin K, carnitine, ferulic acid, .gamma.-oryzanol, alpha-lipoic acid, vitamins and vitamin-like agents such as orotic acid;

  Benzoic acid, sodium benzoate, undecylenic acid, salicylic acid, sorbic acid, potassium sorbate, dehydroacetic acid, sodium dehydroacetate, isobutyl parahydroxybenzoate, isopropyl parahydroxybenzoate, ethyl parahydroxybenzoate, butyl parahydroxybenzoate, Preservatives such as propyl parahydroxybenzoate, benzyl parahydroxybenzoate, methyl parahydroxybenzoate, methyl sodium parahydroxybenzoate, phenoxyethanol, photosensitizer 101, photosensitizer 201, photosensitizer 401;

  Antioxidants such as butylhydroxyanisole, butylhydroxytoluene, propyl gallate, erythorbic acid, sodium erythorbate, parahydroxyanisole, octyl gallate;

  Metal ion sequestering agents such as trisodium ethylenediaminehydroxyethyl triacetate, edetic acid, disodium edetate, trisodium edetate, tetrasodium edetate, sodium citrate, gluconic acid, phytic acid, sodium polyphosphate, sodium metaphosphate ;

  Moisturizers such as hyaluronic acid, sodium hyaluronate, sodium chondroitin sulfate, sodium lactate, sodium pyrrolidonecarboxylate, betaine, lactic acid bacteria culture, yeast extract, ceramide;

  Anti-inflammatory agents such as glycyrrhizic acid, trisodium glycyrrhizinate, dipotassium glycyrrhizinate, monoammonium glycyrrhizinate, β-glycyrrhetinic acid, glyceryl glycyrrhetinate, stearyl glycyrrhetinate, lysozyme chloride, hydrocortisone, allantoin;

PH adjusters such as sodium hydroxide, potassium hydroxide, triethanolamine;
Salts such as sodium chloride, potassium chloride, magnesium chloride, sodium sulfate;

  Α-hydroxy acids such as citric acid, glycolic acid, tartaric acid, lactic acid;

  Whitening agents such as arbutin, α-arbutin, placenta extract;

  Angelica oil, Ylang-Ylang oil, Elemi oil, Orange oil, Chamomile oil, Roman chamomile oil, Cardamom oil, Calamus oil, Galvanum oil, Camphor oil, Carrot seed oil, Clarage sage oil, Grapefruit oil, Clove oil, Keihi oil, Coriander oil , Cypress oil, Sandalwood oil, Cedarwood oil, Citronella oil, Cinnamon leaf oil, Jasmine absolute, Juniper berry oil, Ginger extract, Spearmint oil, Sage oil, Cedar oil, Geranium oil, Thyme oil, Tea tree oil, Nutmeg oil , Near uri oil, neroli oil, pine oil, basil oil, peppermint oil, patchouli oil, palmarosa oil, fennel oil, petitgren oil, black pepper oil, frankincense oil, vetiver oil, peppermint oil, bergamot oil Zoin oil, Boad Rose oil, Marjoram oil, Mandarin oil, Myrrh oil, Melissa oil, Eucalyptus oil, Yuzu oil, Lime oil, Lavensara oil, Lavandin oil, Lavender oil, Linden oil, Lemon oil, Lemongrass oil, Rose oil, Rose Essential oils such as wood oil, rosemary oil, lobe oil;

  Terpenes such as limonene, pinene, terpinene, terpinolene, myrcene, longiferin, etc .;

  Perfume; water etc.

  These components can be contained in the external preparation for skin as long as the effects of the present invention are not impaired, but are usually 0.01 to 90% by mass, preferably 0.1 to 25% by mass in the total amount of external preparation for skin. More preferably, it can be contained in an amount of 0.3 to 10% by mass.

<External preparation for skin, cosmetics>
The skin external preparation of the present invention contains a salt of a higher fatty acid ester of ascorbic acid-2-phosphate and a polyhydric alcohol, and further contains the above-described other components as necessary. However, cosmetics are the most common embodiment as a skin external preparation.

  In the present specification, the cosmetic is any kind of skin milk, skin cream, foundation cream, massage cream, cleansing cream, shaving cream, cleansing foam, lotion, as long as it is in contact with the skin during use. It has a broad meaning including lotion, pack, shampoo, rinse, hair restorer, hair nourishing agent, hair dye, hair conditioner, toothpaste, mouthwash, permanent wave agent, ointment, bathing agent, body soap, etc. Regardless of old or young.

  In addition, when the skin external preparation of this invention is cosmetics, what can generally be used as cosmetics can be used among other components (C) mentioned above, In addition to these, other components Existing cosmetic raw materials other than (C) can also be used.

  For example, Cosmetic Material Standards Second Edition Annotation, edited by Japan Standards Association, 1984 (Pharmaceutical Daily Report), Cosmetic Raw Material Standards Ingredient Standard, Ministry of Health and Welfare Pharmaceutical Affairs Bureau Examination Division Supervision, 1993 (Pharmaceutical Daily Report), Cosmetic Raw Material Standards Ingredients Standards supplement, supervised by the Ministry of Health and Welfare Pharmacy Examination Division, 1993 (Pharmaceutical Daily), permission standards by cosmetic type, supervision by the Ministry of Health and Welfare Pharmacy Examination Division, 1993 (Pharmaceutical Daily), formulation standard by cosmetic product, Ministry of Health and Welfare All cosmetic raw materials described in supervision, 1997 (Pharmaceutical Daily), cosmetic raw material dictionary, 1991 (Nikko Chemicals), etc. can be used.

  These cosmetic raw materials are a total amount combined with the other component (C) described above, and are 0.01 to 90% by mass, preferably 0.1 to 25% by mass, more preferably 0.3% in the total amount of the cosmetic. It can be made to contain in the quantity of -10 mass%.

  The external preparation for skin and cosmetics of the present invention can be produced by using the above-described components so as to have a predetermined content, and dissolving, mixing, or dispersing in accordance with a conventional method according to the mode.

<Method and method for stabilizing skin external preparation containing salt of higher fatty acid ester of ascorbic acid-2-phosphate>
As described above, in the external preparation for skin of the present invention, a higher fatty acid ester salt of ascorbic acid-2-phosphate and a higher fatty acid ester of ascorbic acid-2-phosphate are contained together with a polyhydric alcohol. Even when a salt of a fatty acid ester is formulated as a skin external preparation, turbidity and precipitation over time can be suppressed.

  In other words, by using a polyhydric alcohol as a stabilizer and coexisting a polyhydric alcohol and a salt of a higher fatty acid ester of ascorbic acid-2-phosphate, a higher fatty acid of ascorbic acid-2-phosphate is used. It is possible to stabilize a skin external preparation containing an ester salt. Therefore, the polyhydric alcohol can be suitably used as a stabilizer for an external preparation for skin containing a salt of a higher fatty acid ester of ascorbic acid-2-phosphate.

  EXAMPLES Hereinafter, although this invention is demonstrated further more concretely based on an Example, this invention is not limited to these Examples. The glycerin listed below was glycerin content of 98% by mass or more. The numerical value in a table | surface is the mass%, and the total of each component is 100 mass%.

In the following examples, turbidity and precipitation were evaluated according to the following criteria.
(1) Evaluation of turbidity Visual evaluation was performed according to the following evaluation criteria.

-: No turbidity is observed at all. ±: Slight turbidity is observed. +: The turbidity is significant. (2) Precipitation evaluation Visual evaluation was performed according to the following evaluation criteria.

-: No precipitation is seen ±; Slight precipitation is seen +; Precipitation is remarkable

[Examples 1 to 4, Comparative Example 1]

  According to the blending ratio shown in Table 1, the components 1 to 6 were mixed, stirred, and dissolved uniformly to obtain the lotions of Comparative Example 1 and Examples 1 to 4. The obtained lotion was allowed to stand at 40 ° C., and turbidity and precipitation were examined over time. The evaluation of turbidity and precipitation was visually performed according to the above evaluation criteria. The evaluation results after 1 month of standing at 40 ° C. are shown in Table 1.

  From Table 1, it turns out that generation | occurrence | production of turbidity and precipitation is suppressed compared with the comparative example 1 in Examples 1-4, and the stability of lotion is improving.

The propylene glycol concentrations in Example 1 and Comparative Example 1 were quantified by gas chromatography as follows.
1 g of a sample was diluted with acetone, and the volume was adjusted to 10 ml to obtain a sample solution. A calibration curve was prepared from a gas chromatogram of a standard solution of propylene glycol, and the amount of propylene glycol in the sample solution was quantified from the calibration curve. The conditions for gas chromatography are as follows.

Device: HP6890
Column: J & W Scientific DB-1 (inner diameter 0.32 mm, length 30 m,
(Film thickness 5μm)
Column oven temperature: 50 ° C (1 minute), temperature rise at 20 ° C / minute, 320 ° C (10 minutes)
Carrier gas: He
Column flow rate: 1.5 ml / min Injection mode: Split (1:50)
Injection volume: 1 μl
FID temperature: 320 ° C
As a result, the propylene glycol concentrations in Example 1 and Comparative Example 1 were 5% by mass and 0% by mass, respectively.

[Examples 5 to 9, Comparative Example 2]
According to the blending ratio shown in Table 2, the components 1 to 5 were mixed, stirred, and uniformly dissolved to obtain the lotions of Comparative Example 2 and Examples 5 to 9. The obtained lotion was allowed to stand at 40 ° C., and turbidity and precipitation were examined over time. The evaluation of turbidity and precipitation was visually performed according to the above evaluation criteria. The evaluation results after 1 month of standing at 40 ° C. are shown in Table 2.

  From Table 2, it turns out that generation | occurrence | production of turbidity and precipitation is suppressed in Examples 5-9 compared with the comparative example 2, and the stability of lotion is improving.

[Examples 10 to 12, Comparative Example 3]
According to the compounding ratio shown in Table 3, 1 to 10 components were mixed, stirred, and uniformly dissolved to obtain the lotions of Comparative Example 3 and Examples 10 to 12. The obtained lotion was allowed to stand at 40 ° C., and turbidity and precipitation were examined over time. The evaluation of turbidity and precipitation was visually performed according to the above evaluation criteria. Table 3 shows the evaluation results after 1 month of standing at 40 ° C.

  From Table 3, it turns out that generation | occurrence | production of turbidity and precipitation is suppressed in Examples 10-12 compared with the comparative example 3, and the stability of lotion is improving.

[Examples 13 to 15, Comparative Example 4]
According to the compounding ratio shown in Table 4, 1 to 10 components were mixed, stirred, and uniformly dissolved to obtain lotions of Comparative Example 4 and Examples 13 to 15. The obtained lotion was allowed to stand at 40 ° C., and turbidity and precipitation were examined over time. The evaluation of turbidity and precipitation was visually performed according to the above evaluation criteria. Table 4 shows the evaluation results after 1 month of standing at 40 ° C.

  From Table 4, it turns out that generation | occurrence | production of turbidity and precipitation is suppressed in Examples 13-15 compared with the comparative example 4, and the stability of lotion is improving.

[Examples 16 to 21, Comparative Example 5]
According to the blending ratio shown in Table 5, 1 to 10 components were mixed, stirred, and uniformly dissolved to obtain cosmetic liquids of Comparative Example 5 and Examples 16 to 21. The obtained cosmetic liquid was allowed to stand at 40 ° C., and turbidity and precipitation were examined over time. The evaluation of turbidity and precipitation was visually performed according to the above evaluation criteria. Table 5 shows the evaluation results after 1 month of standing at 40 ° C.

  From Table 5, it turns out that generation | occurrence | production of turbidity and precipitation is suppressed in Examples 16-21 compared with the comparative example 5, and the stability of a cosmetic liquid is improving.

[Examples 22 to 27, Comparative Example 6]
According to the blending ratio shown in Table 6, components 1 to 10 were mixed, stirred, and dissolved uniformly to obtain the cosmetic liquids of Comparative Example 6 and Examples 22 to 27. The obtained cosmetic liquid was allowed to stand at 40 ° C., and turbidity and precipitation were examined over time. The evaluation of turbidity and precipitation was visually performed according to the above evaluation criteria. Table 6 shows the evaluation results after 1 month of standing at 40 ° C.

  From Table 6, it turns out that generation | occurrence | production of turbidity and precipitation is suppressed in Examples 22-27 compared with the comparative example 6, and the stability of a cosmetic liquid is improving.

[Examples 28 to 33, Comparative Example 7]
According to the blending ratio shown in Table 7, the components 1 to 8 were mixed, stirred, and dissolved uniformly to obtain the lotions of Comparative Example 7 and Examples 28 to 33. The obtained lotion was allowed to stand at 40 ° C., and turbidity and precipitation were examined over time. The evaluation of turbidity and precipitation was visually performed according to the above evaluation criteria. Table 7 shows the evaluation results after one month of standing at 40 ° C.

  From Table 7, it turns out that generation | occurrence | production of turbidity and precipitation is suppressed in Examples 28-33 compared with the comparative example 7, and the stability of lotion is improving.

[Examples 34 to 39, Comparative Example 8]
According to the blending ratio shown in Table 8, the components 1 to 8 were mixed, stirred, and uniformly dissolved to obtain lotions of Comparative Example 8 and Examples 34 to 39. The obtained lotion was allowed to stand at 40 ° C., and turbidity and precipitation were examined over time. The evaluation of turbidity and precipitation was visually performed according to the above evaluation criteria. The evaluation results after 1 month of standing at 40 ° C. are shown in Table 8.

  From Table 8, it turns out that generation | occurrence | production of turbidity and precipitation is suppressed in Examples 34-39 compared with the comparative example 8, and the stability of lotion is improving.

[Examples 40 to 41, Comparative Example 9]
According to the blending ratio shown in Table 9, the components 1 to 9 were mixed, stirred, and dissolved uniformly to obtain the cosmetic liquids of Comparative Example 9 and Examples 40 to 41. The obtained cosmetic liquid was allowed to stand at 40 ° C., and turbidity and precipitation were examined over time. The evaluation of turbidity and precipitation was visually performed according to the above evaluation criteria. Table 9 shows the evaluation results after 1 month of standing at 40 ° C.

  From Table 9, it turns out that generation | occurrence | production of turbidity and precipitation is suppressed compared with the comparative example 9 in Examples 40-41, and the stability of a cosmetic liquid is improving.

[Examples 42 to 43, Comparative Example 10]
According to the blending ratio shown in Table 10, the components 1 to 9 were mixed, stirred, and dissolved uniformly to obtain the cosmetic liquids of Comparative Example 10 and Examples 42 to 43. The obtained cosmetic liquid was allowed to stand at 40 ° C., and turbidity and precipitation were examined over time. The evaluation of turbidity and precipitation was visually performed according to the above evaluation criteria. Table 10 shows the evaluation results after 1 month of standing at 40 ° C.

  From Table 10, it turns out that generation | occurrence | production of turbidity and precipitation is suppressed compared with the comparative example 10 in Examples 42-43, and the stability of a cosmetic liquid is improving.

Claims (18)

A skin external preparation characterized by containing a salt of a higher fatty acid ester of ascorbic acid-2-phosphate represented by the following general formula (1) and a polyhydric alcohol;

(Wherein R represents a higher fatty acid residue).   The skin external preparation according to claim 1, wherein R in the general formula (1) is a residue of an aliphatic carboxylic acid having 10 to 20 carbon atoms.   The external skin preparation according to claim 1 or 2, wherein R in the general formula (1) is a residue of lauric acid, myristic acid, palmitic acid, stearic acid, 2-hexyldecanoic acid or isostearic acid. .   The external preparation for skin according to any one of claims 1 to 3, wherein R in the general formula (1) is a residue of palmitic acid.   R of the said General formula (1) is a residue of 2-hexyl decanoic acid, The skin external preparation in any one of Claims 1-3 characterized by the above-mentioned.   The skin external preparation according to any one of claims 1 to 5, wherein the salt of the higher fatty acid ester of ascorbic acid-2-phosphate is Na salt, K salt, Mg salt or Zn salt.   The skin external preparation according to any one of claims 1 to 6, comprising a salt of a higher fatty acid ester of the ascorbic acid-2-phosphate ester in an amount of 0.01 to 20% by mass.   The polyhydric alcohol is a dihydric alcohol having 5 or 6 carbon atoms (however, if the number of carbon atoms is 5 or 6, a heteroatom may be inserted in the carbon chain). The skin external preparation in any one of Claims 1-7 to do. The dihydric alcohol having 5 or 6 carbon atoms is triethylene glycol, dipropylene glycol, 3-methyl-1,3-butanediol, 1,2-pentanediol, 1,4-pentanediol, 1,5- Selected from the group consisting of pentanediol, 2,4-pentanediol, 2-methyl-2,4-pentanediol, 3-methyl-1,5-pentanediol, 1,2-hexanediol and 1,6-hexanediol The skin external preparation according to claim 8, wherein the skin external preparation is at least one kind.   The skin external preparation according to claim 8 or 9, wherein the dihydric alcohol having 5 or 6 carbon atoms is contained in an amount of 0.05% by mass or more and less than 12% by mass.   The polyhydric alcohol is a divalent or higher alcohol having 2, 3, 4 or 7 carbon atoms (provided that if the carbon atom number is 3, 4 or 7 or more, a heteroatom is inserted in the carbon chain) The skin external preparation according to any one of claims 1 to 7, wherein the alcohol is contained in an amount of 12 to 90% by mass.   The divalent or higher alcohol having 2, 3, 4 or 7 or more carbon atoms (however, if the number of carbon atoms is 3, 4 or 7 or more, a hetero atom may be inserted in the carbon chain). The skin according to claim 11, wherein the skin is at least one selected from the group consisting of ethylene glycol, propylene glycol, glycerin, 1,3-butanediol, diethylene glycol, polyethylene glycol, polypropylene glycol, and polyglycerin. Topical agent.   Water is contained, The skin external preparation in any one of Claims 1-12 characterized by the above-mentioned.   Cosmetics containing the skin external preparation in any one of Claims 1-13. A method for stabilizing a skin external preparation containing a salt of a higher fatty acid ester of ascorbic acid-2-phosphate represented by the following general formula (1), characterized by using a polyhydric alcohol;

(Wherein R represents a higher fatty acid residue).   The polyhydric alcohol is a dihydric alcohol having 5 or 6 carbon atoms (provided that a heteroatom may be inserted in the carbon chain if the number of carbon atoms is 5 or 6). The method for stabilizing an external preparation for skin according to claim 15. A stabilizer for external preparations for skin containing a salt of a higher fatty acid ester of ascorbic acid-2-phosphate represented by the following general formula (1), comprising a polyhydric alcohol;

(Wherein R represents a higher fatty acid residue).   The polyhydric alcohol is a dihydric alcohol having 5 or 6 carbon atoms (however, if the number of carbon atoms is 5 or 6, a heteroatom may be inserted in the carbon chain). The stabilizer for external skin preparations according to claim 17.