JP2013209319A - Oil-in-water type emulsified composition incorporated with ascorbic acid derivative - Google Patents

Abstract

PROBLEM TO BE SOLVED: To provide an emulsified composition incorporated with a salt of a higher fatty acid ester of ascorbic acid-2-phosphate ester.SOLUTION: An oil-in-water type emulsified composition contains following components (a)-(f): (a) phospholipid and/or lysophospholipid; (b) monoalkyl glyceryl ether; (c) antioxidant containing sulphur selected from pyrosulfite, sulfite, hydrogen sulfite, dithionite and thiosulfate; (d) a chelating agent; (e) a salt of higher fatty acid ester of ascorbic acid-2-phosphate; and (f) a higher alcohol which is solid at 25 °C. The oil-in-water type emulsified composition can be used as a cosmetic material or an external skin agent as it is, and can be added to a cosmetic material or an external skin agent to give various forms.

Description

  The present invention relates to an oil-in-water emulsion composition containing a salt of a higher fatty acid ester of ascorbic acid-2-phosphate. The composition of the present invention can be used as a cosmetic or an external preparation for skin, and can also be used by adding to the cosmetic or an external preparation for skin.

  A higher fatty acid ester of ascorbic acid-2-phosphate which is a vitamin C derivative is used in various cosmetic compositions as an amphiphilic component having functions such as whitening, anti-inflammation and anti-aging. In order to improve the stability of this component, several techniques have been investigated.

Patent Document 1 describes a skin external preparation characterized by containing a salt of a higher fatty acid ester of ascorbic acid-2-phosphate and a polyhydric alcohol. According to this, ascorbic acid- It is stated that even when a salt of a higher fatty acid ester of 2-phosphate ester is formulated as a skin external preparation, turbidity and precipitation can be prevented over time. Patent Document 2 contains a fatty acid ester of L-ascorbic acid-2-phosphate and / or a salt thereof, a liquid oil having an IOB value of 0.07 to 0.65, a surfactant, and water. An oil-in-water composition is described, and according to this, hydrolysis of a fatty acid ester of L-ascorbic acid-2-phosphate which is an active ingredient and / or a salt thereof in the oil-in-water composition is suppressed. It is stated that stable blending is possible. Furthermore, in Patent Document 3, a composition containing a specific ascorbic acid-2-phosphate derivative, a nonionic surfactant and water is prepared, and this is mixed with a divalent or higher metal salt or an aqueous solution thereof. The composition characterized by having prepared by this is described, and it is stated that according to this, the stability of the ascorbic acid derivative can be remarkably improved. Further, Patent Document 4 is not related to an ascorbic acid ester, but relates to the blending of a retinoid having a common oil-soluble property, which includes at least a retinoid and a lipid bilayer film composed of hydrogenated phospholipid. A retinoid stabilizing composition characterized by containing retinoid-encapsulated particles encapsulating a hydrophobic antioxidant is described. Further, it is described that such a retinoid stabilizing composition can provide an aqueous preparation having excellent stability with time, non-stickiness and fresh feeling. Further, Patent Document 5 is characterized by containing a salt (A) of a higher fatty acid ester of ascorbic acid-2-phosphate, a water-soluble synthetic polymer compound (B), and water (C). A skin external preparation is described, and according to this, the decomposition and reduction of a higher fatty acid ester salt of ascorbic acid-2-phosphate ester represented by the above formula (1) in the preparation can be prevented, and the skin external preparation It is stated that coloring and / or precipitation (turbidity) can be suppressed.

JP 2005-336156 (Patent 0467328) JP2009-249325 JP2007-320858 JP 2009-256268 A JP-A-2005-187466

However, the conventional method cannot be said to have sufficient stability over time of the ascorbic acid derivative. In particular, there was a difficulty in stability over time at high temperatures. In the emulsified composition stored over time, thermal decomposition progressed in particular, and the problem of yellowing (or browning) due to discoloration of ascorbic acid as a decomposition product occurred.
In addition, the ascorbic acid derivative that behaves as a salt causes a problem of stability over time such as separation of the emulsion composition.

  As a result of studies by the present inventors, it has been found that when a salt of a higher fatty acid ester of ascorbic acid-2-phosphate is included, an emulsified composition based on phospholipid is suitable. Furthermore, it discovered that the thing which hold | maintained sufficient stability as an emulsion composition could be prepared by combining a specific component, and completed this invention.

The present invention provides the following.
[1] The following components (a) to (f);
(A) Phospholipid and / or lysophospholipid (b) Monoalkyl glyceryl ether (c) Sulfur-containing antioxidant compound selected from pyrosulfite, sulfite, bisulfite, dithionate and thiosulfate (d) Chelating agent (e) Higher fatty acid ester salt of ascorbic acid-2-phosphate (f) An oil-in-water emulsion composition containing a higher alcohol that is solid at 25 ° C.
[2] The oil-in-water emulsion composition according to [1], wherein the component (b) is monostearyl glyceryl ether.
[3] The oil-in-water emulsion composition according to [1] or [2], wherein the component (d) is selected from disodium edetate and pentasodium diethylenetriaminepentaacetate.
[4] The component (f) is one or more selected from higher alcohols having 16 to 18 carbon atoms and one or more selected from higher alcohols having 20 to 24 carbon atoms. ] The oil-in-water emulsion composition as described in any one of [3].
[5] The oil-in-water type according to any one of [1] to [4], further comprising POE cholesteryl ether and / or POE phytosteryl ether having an HLB value of 7 or more and 10 or less as component (g) Emulsified composition.
[6] The oil-in-water emulsion composition according to any one of [1] to [5], which is a cosmetic or an external preparation for skin.
[7] A cosmetic or external preparation for skin containing the oil-in-water emulsion composition according to any one of [1] to [5].
[8] A cosmetic or external skin preparation comprising the steps of preparing the oil-in-water emulsion composition according to any one of [1] to [5] and adding the prepared oil-in-water emulsion composition Manufacturing method.

  ADVANTAGE OF THE INVENTION According to this invention, the stability at the high temperature in the emulsion composition of the salt of the higher fatty acid ester of ascorbic acid 2-phosphate ester improves.

  According to the present invention, an emulsified composition containing a salt of a higher fatty acid ester of ascorbic acid-2-phosphate, which is excellent in stability in an emulsified state at high temperature and stability in appearance properties at high temperature. A cosmetic or an external preparation for skin can be obtained.

The oil-in-water emulsion composition of the present invention contains the following components:
(A) Phospholipid and / or lysophospholipid (b) monoalkyl glyceryl ether (c) one of sulfur-containing antioxidant compounds selected from pyrosulfite, sulfite, bisulfite, dithionate and thiosulfate Or (d) a chelating agent (e) a salt of a higher fatty acid ester of ascorbic acid-2-phosphate (f) an oil-in-water emulsion composition containing a higher alcohol that is solid at 25 ° C.

  In addition, when a numerical range is represented by "X-Y" by this invention, both ends X and Y are included except the case where it describes. The term “salt” with respect to the component of the present invention refers to a salt acceptable as a cosmetic or an external preparation for skin unless otherwise specified, and includes sodium salt, potassium salt, magnesium salt, or Zinc salts and the like are included.

[Component (a)]
The emulsified composition of the present invention contains phospholipid and / or lysophospholipid.

  The phospholipid of component (a) is generally phospholipid such as soybean lecithin extracted from natural soybean or egg yolk, egg yolk lecithin and / or hydrogenated lecithin hydrogenated with these, hydrogenated soybean lecithin, hydrogenated egg yolk lecithin or synthetic phospholipid. Those known as lipids can be used. As the type of phospholipid, for example, phosphatidylcholine, phosphatidylethanolamine, phosphatidylserine, phosphatidic acid, phosphatidylinositol and the like are preferably used. Examples of the fatty acid constituting the phospholipid include saturated and unsaturated carboxylic acids having 7 to 22 carbon atoms. Examples of commercially available products include Resinol S-10E (Nikko Chemical Co., Ltd.), HSL-70 (YMC Corporation), Basis LS-60HR (Nisshin Oilio Group Co., Ltd.), and the like.

  The lysophospholipid of the component (a) of the present invention is one of enzyme-modified phospholipids and is obtained by hydrolyzing the phospholipid with an ester bond at the 2-position by phospholipase. Since lysophospholipids have only one fatty acid that is a hydrophobic group, HLB is higher than phospholipids having double-chain fatty acids. In many cases, lysophospholipids contain an unsaturated fatty acid in the structure thereof, and the unsaturated fatty acid portion is oxidized by light or oxygen to cause coloring, generation of off-flavor, and the like, which may deteriorate the quality. Therefore, in order to prevent these quality degradations, there are hydrogenated lysophospholipids in which unsaturated bonds are hydrogenated to form saturated bonds, which can be used as the component (a) of the present invention.

  The lysophospholipid of component (a) used in the present invention may contain a plurality of lysophospholipids such as lysophosphatidylcholine and lysophosphatidylethanolamine. Among these, at least lysophosphatidylcholine is preferably contained, more preferably 15% or more, and even more preferably 20% or more. When lysophosphatidylcholine is contained at 15% or more, it is preferable in terms of storage stability.

  The compounding amount of the component (a) of the present invention is not particularly limited, but is 0.1 to 5% by mass (hereinafter simply referred to as “%”) with respect to the total amount of the composition in terms of stability at high temperatures. (Omitted) is preferable, and 0.3 to 1.5% is more preferable.

[Component (b)]
The emulsified composition of the present invention contains a monoalkyl glyceryl ether. The component (b) of the present invention, together with the component (f), can act as an emulsification aid that improves emulsification.

  Component (b) monoalkyl glyceryl ether of the present invention refers to a nonionic surfactant in which the hydroxyl group at the 1-position in glycerin is etherified, and the alkyl chain preferably has 8 to 24 carbon atoms, and is a cosmetic or skin. If it is used for an external preparation, it will not specifically limit. Among these, 16 to 22 linear alkyl groups are more preferable from the viewpoint of stability at high temperatures. Specific examples include glycerin monostearyl ether, glycerin monocetyl ether, glycerin monooleyl ether, and the like, and one or more can be used as necessary. From the viewpoint of stability in the emulsified state, glyceryl monocetyl ether (chimyl alcohol) and glyceryl monostearyl ether (batyl alcohol) are preferable, and glycerin monostearyl ether is more preferable in terms of stability over time.

  Although the compounding quantity of the component (b) of this invention is not specifically limited, It is preferable that it is 0.05 to 2% with respect to the whole quantity of a composition, and 0.1-. 5% is more preferable.

[Component (c)]
The emulsified composition of the present invention contains one or more sulfur-containing compounds selected from pyrosulfite, sulfite, bisulfite, dithionite and thiosulfate. The component (c) of the present invention can exhibit an antioxidant action and can prevent oxidative degradation of the component (e).

  As the component (c), one or two or more kinds can be used as necessary, and at least pyrosulfite or thiosulfate is preferably used, and sodium pyrosulfite or sodium thiosulfate is more preferably used. From the viewpoint of particularly suppressing discoloration of the appearance, sodium pyrosulfite is preferably used, and from the viewpoint of stability over time, sodium thiosulfate is preferably used.

  The amount of the component (c) of the present invention is not particularly limited, but is preferably 0.0003 to 0.03% with respect to the total amount of the composition. -0.01% is more preferable.

[Component (d)]
The emulsified composition of the present invention contains a chelating agent.

  As a component (d), 1 type (s) or 2 or more types can be used as needed. Examples of component (d) are ethylenediaminetetraacetic acid (EDTA), ethylenetriaminepentaacetic acid (DTPA), ethylene glycol bis (2-aminoethyl ether) tetraacetic acid, 1-hydroxyethylidene-1,1-diphosphonic acid (HEDP) , Ethylenediaminetetra (methylenephosphonic acid), ditartaric acid, citric acid, polyphosphoric acid, metaphosphoric acid, or salts thereof. Among these, one or more selected from ethylenediaminetetraacetic acid (EDTA), ethylenetriaminepentaacetic acid (DTPA), or salts thereof are preferable. A preferred example of ethylenetriaminepentaacetic acid (DTPA) is DTPA 5Na.

  The compounding amount of the component (d) of the present invention is not particularly limited, but is preferably 0.01 to 1% with respect to the total amount of the composition. .3% is more preferred.

[Component (e)]
In the present invention, “a salt of a higher fatty acid ester of ascorbic acid-2-phosphate” refers to a phosphoric acid ester-bonded to the hydroxyl group at the 2-position of ascorbic acid, and the hydroxyl group at the 6-position, unless otherwise specified. A compound in which a higher fatty acid is ester-bonded, wherein a phosphate residue ester-bonded to the hydroxyl group at the 2-position forms a salt.

  The ester-linked higher fatty acid residue is preferably an aliphatic carboxylic acid residue having 10 to 20 carbon atoms, and more preferably lauric acid, myristic acid, palmitic acid, stearic acid, 2-hexyldecanoic acid or isostearic acid. More preferably, it is a residue of palmitic acid.

  Examples of the salt are not particularly limited as long as they are acceptable as cosmetics or skin external preparations. Examples include salts of alkali metals, alkaline earth metals, tertiary amines, and the like. Preferred examples include the sodium salt, potassium salt, magnesium salt, or zinc salt described above.

  A preferable example of a salt of a higher fatty acid ester of ascorbyl 2-phosphate used in the present invention is a salt of ascorbyl palmitate, more specifically, a sodium salt or magnesium salt of ascorbyl palmitate. is there. An example of a salt of a higher fatty acid ester of ascorbic acid-2-phosphate particularly preferably used in the present invention is ascorbyl palmitate (chemical name: trisodium L-ascorbate-2-phosphate). ascorbyl 2-phosphate)).

  In the present invention, as a salt of a higher fatty acid ester of ascorbic acid-2-phosphate, only one type may be used, or two or more types may be used in combination.

  The salt of higher fatty acid ester of ascorbic acid-2-phosphate is obtained by adding lipophilicity to the water-soluble ascorbic acid derivative by further introducing a higher fatty acid residue into the phosphate ester of ascorbic acid. It is medium. Compared to existing ascorbic acid derivatives, it has superior skin permeability, promotes collagen synthesis in the skin, and can be expected to have an anti-aging effect.

  The blending amount of the higher fatty acid ester salt of ascorbic acid-2-phosphate in the oil-in-water emulsion composition of the present invention can be 0.01 to 5%, and 0.05 to 3%. Is preferred.

[Component (f)]
The emulsified composition of the present invention contains a higher alcohol that is solid at 25 ° C. If a solid higher alcohol is blended at 25 ° C., the interface of the emulsified droplets can be stabilized, and the stability at high temperature can be further improved.

  Component (f) is preferably a monohydric alcohol having 12 to 24 carbon atoms, and specifically includes cetyl alcohol, stearyl alcohol, behenyl alcohol and the like, and these higher alcohols are used singly or in combination as required. be able to. From the viewpoint of increasing the stability, two or more types are preferably used in combination. Specifically, the component (f) preferably comprises at least one selected from higher alcohols having 16 to 18 carbon atoms and one or more selected from higher alcohols having 20 to 24 carbon atoms.

  The blending amount of the component (f) is preferably 0.15 to 15% from the viewpoint that an oil-in-water emulsified cosmetic having good stability at high temperature over a long period of time can be obtained, and 0.3 to 5 % Is more preferable.

[Ingredient (g)]
In the composition of the present invention, polyoxyethylene cholesteryl ether and / or polyoxyethylene phytosteryl ether having an HLB value of 7 or more and 10 or less may be used (hereinafter, polyoxyethylene may be abbreviated as “POE”). The following are synonymous). It is preferable to add the component (g) because the stability over time is further improved. Specific examples of such component (g) include POE (5) phytosterols, POE (10) phytosterols, POE (20) phytosterols, POE (25) phytosterols, POE (30) phytosterols and other polyoxyethylene glycol phytosterols. Polyoxyethylene cholesteryl ethers such as POE (5) cholesteryl ether, POE (10) cholesteryl ether, POE (15) cholesteryl ether, POE (20) cholesteryl ether, POE (24) cholesteryl ether, POE (30) cholesteryl ether Selected from.

  A component (g) can be used individually or in combination of 2 or more types, respectively. As a preferable compounding quantity, it is 0.005-0.5%, More preferably, it is 0.01-0.3%. When it mix | blends in this range, since stability in high temperature becomes favorable, it is preferable.

[Oil phase]
The composition of the present invention is an oil-in-water emulsion composition and uses an oil agent for the oil phase. The oil agent is an essential component for constituting the emulsified composition, and the oil component can exert an action of softening the skin and imparting a moist feeling to the skin.

  As the oil used in the present invention, the origin of animal oils, vegetable oils, synthetic oils and the like commonly used in cosmetics and the properties of solid oils, semi-solid oils, liquid oils, volatile oils, hydrocarbons, Fats, waxes, hardened oils, ester oils, fatty acids, silicone oils, fluorine oils, lanolin derivatives, oily gelling agents, lipophilic surfactants, oil-soluble UV absorbers, etc. Is mentioned. Specifically, hydrocarbons such as liquid paraffin, squalane, petrolatum, polyisobutylene, polybutene, paraffin wax, ceresin wax, microcrystalline wax, montan wax, fish trops wax, olive oil, castor oil, jojoba oil, mink oil , Vegetable oils such as macadamian nut oil, beeswax, carnauba wax, candelilla wax, waxes such as gay wax, owl, cetyl isooctanoate, isopropyl myristate, isopropyl palmitate, octyldodecyl myristate, glyceryl trioctanoate, Polyglyceryl diisostearate, diglyceryl triisostearate, glyceryl tribehenate, pentaerythritol ester of rosin acid, neopentyl glycol dioctanoate, Esters of terol fatty acid esters, N-lauroyl-L-glutamic acid di (cholesteryl, behenyl, octyldodecyl), fatty acids such as stearic acid, lauric acid, myristic acid, behenic acid, isostearic acid, oleic acid, rosin acid, Silicones such as low polymerization dimethylpolysiloxane, high polymerization dimethylpolysiloxane, methylphenylpolysiloxane, decamethylcyclopentasiloxane, octamethylcyclotetrasiloxane, polyether-modified polysiloxane, cross-linked organopolysiloxane, fluorine-modified silicone Fluorine oils such as perfluoropolyether, perfluorodecane, perfluorooctane, lanolin derivatives such as lanolin, lanolin acetate, lanolin fatty acid isopropyl, lanolin alcohol, Oily gelling agents such as string fatty acid ester, sucrose fatty acid ester, starch fatty acid ester, 12-hydroxystearic acid, aluminum stearate, calcium stearate, lipophilicity such as glyceryl monostearate, sorbitan tristearate, sorbitan sesquioleate Surfactants, ethyl paraaminobenzoate, paramethoxycinnamate-2-ethylhexyl, oil-soluble UV absorbers such as 4-tert-butyl-4'-methoxydibenzoylmethane, oxybenzone, and the like Can be used singly or in combination of two or more.

  1-20% is preferable and, as for the compounding quantity of an oil agent, 3-10% is more preferable. Within this range, the oil-in-water liquid composition is excellent in stability at high temperatures, and the skin effect is preferred when used on the skin.

[Water phase]
The composition of the present invention is an oil-in-water emulsified composition, and water is used as an aqueous phase medium. Water is an essential component for constituting the emulsified composition, and can impart a fresh feel to the skin during and after use.

  The water that can be used is not particularly limited as long as it is acceptable as a cosmetic or an external preparation for skin. For example, in addition to purified water, hard water, soft water, natural water, tap water, seawater, deep ocean water, electrolysis Alkaline ion water, electrolytic acid ion water, ion water, and cluster water can be used. The blending amount of water is not particularly limited, and can be blended appropriately according to the amount of other components.

[Other ingredients, other]
In the composition of the present invention, a pH adjusting agent may be used. The pH of the composition can be adjusted to 6.0 to 8.0 in consideration of the hydrolysis of the phospholipid and considering the stability of the emulsified state (stability with time). The pH adjuster is not particularly limited as long as it is acceptable as a component for external use on the skin. Examples of the pH adjusting agent that can be used in the present invention include citric acid and / or a salt thereof, phosphoric acid and / or a salt thereof, tartaric acid and / or a salt thereof, lactic acid and / or a salt thereof. In addition, when mentioning pH by this invention, it is a measured value at 25 degreeC except the case where it describes especially.

  Examples of whitening agents include arbutin, vitamin C and its derivatives, hawthorn extract, Inchinkou (Kawara mugwort) extract, licorice extract, Clara extract, wheat extract, saicin extract, rice and rice bran extract, black Examples include currant extract, Ibukitorano extract, Neubara (Agetsu) extract, Ezocogi extract, Sakuhakuhi extract, Toki extract, coffee extract, pearl barley (Yokuinin) extract and the like.

  Antioxidants include coenzyme Q10, alpha lipoic acid, vitamin E and derivatives thereof, carotenoids, dibutylhydroxytoluene, butylhydroxyanisole, rutin and derivatives thereof, glutathione and derivatives thereof, superoxide dismutase, mannitol, caquette extract, geno shoco Extract, Peonies extract, Superoxide Dismutase, Ginkgo biloba extract, Scarab (Ogon) extract, Mikaika (Maikai, Hermanus) extract, Tormentilla extract, Grape extract, Yashajitsu (Yasha) extract, Yukinoshita extract, Examples include rosemary (mannenro) extract, tea extract (Oolong tea, black tea, green tea, etc.) and the like.

  Furthermore, the composition of the present invention can be blended with an electrolyte that has been difficult to be blended stably into an emulsion. Specifically, for example, glycine, alanine, valine, leucine, isoleucine, phenylalanine, tyrosine, threonine, serine, proline, hydroxyproline, tryptophan, thyroxine, methionine, cystine, cysteine, aspartic acid, glutamic acid, asparagine, glutamine, lysine , Amino acids such as arginine and histidine and water-soluble derivatives of amino acids such as trimethylglycine and N-acetyl-glutamic acid, hydroxyacetic acid, lactic acid, β-hydroxypropionic acid, α-hydroxybutyric acid, α-hydroxyisobutyric acid, α-hydroxy Isocaproic acid, oxalic acid, malonic acid, succinic acid, glutaric acid, adipic acid, pimelic acid, suberic acid, azelaic acid, fumaric acid, maleic acid, malic acid, tartronic acid, citric acid, tartaric acid Sodium salt such as pyrrolidonecarboxylic acid, potassium salt, triethanolamine salt, ammonium salt, dipotassium glycyrrhizinate, urea, L-ascorbic acid-2-sodium phosphate, L-ascorbic acid-2-magnesium phosphate, ascorbic acid glucoside , Phenylbenzimidazole sulfonate, and hydroxymethoxybenzophenone sulfonate. The blending amount of the electrolyte is more preferably 0.1% to 5% from the viewpoint of cosmetic effects and stability at high temperatures.

  In the composition of the present invention, optional components blended in the usual cosmetics or external preparations for skin, specifically alcohols, powders, water-soluble polymers, and film formations, as long as the effects of the present invention are not hindered. Agents, surfactants, oil-soluble gelling agents, organically modified clay minerals, resins, ultraviolet absorbers, preservatives, antibacterial agents, fragrances, antioxidants, pH adjusters, chelating agents and the like can be added.

  The oil-in-water emulsified composition of the present invention can be directly used as the cosmetic or skin external preparation of the present invention, and the oil-in-water type emulsion composition in the production process of the cosmetic or external skin preparation An emulsified composition may be prepared. Moreover, it is also possible to mix | blend the arbitrary components mix | blended with general cosmetics or a skin external preparation with this oil-in-water type emulsion composition 0.1-95%, and it can also be set as cosmetics or a skin external preparation.

  In the form of cosmetics or skin external preparations obtained by the present invention (including the case of an oil-in-water emulsion composition itself and the case of a cosmetic or skin external preparation containing an oil-in-water emulsion composition). There is no particular limitation, and examples thereof include skin care cosmetics such as skin lotions, milky lotions, creams, eye creams, beauty essences, massages, packs, hand creams, body creams, and the like. Moreover, the usage method includes a method of using by hand and fingers, a method of using it by impregnating a nonwoven fabric and the like.

Hereinafter, the present invention will be described in more detail with reference to examples. Note that these do not limit the present invention.
An oil-in-water emulsion composition having the composition shown in the following table was prepared.

[Preparation method]
A: Components (1) to (4) are heated to 75 ° C., and stirred at 4000 rpm for 3 minutes with a disper mixer.
B: Ingredients (5) to (15) are heated to 75 ° C., added to A, and stirred at 4000 rpm for 3 minutes with a disper mixer.
C: Components (16) and (17) mixed and stirred at room temperature are added to B and stirred at 4000 rpm for 3 minutes with a disper mixer. Here, a part of the component (17) is left.
D: The remaining component (17) and components (18) to (23) were added to C and stirred with a disper mixer at 4000 rpm for 3 minutes to obtain an oil-in-water emulsion composition.

[Evaluation method]
About what was stored for one month in a 50 degreeC thermostat, and the Example and comparative example which were stored for one month at room temperature, it determined by the expert about the emulsification state and discoloration by visual observation according to the following.

Emulsified state ◎: No change at all ○: Slight change is observed, but there is no problem △: Separation is seen slightly and quality is problematic ×: Separation is considerably seen
Discoloration ◎: No change at all ○: Slight change is observed, but there is no problem △: Discoloration is slightly seen, causing quality problems ×: Discoloration is considerably seen

  From the results shown in the table, those of the examples were not particularly problematic even in the emulsified state and appearance properties (discoloration) even after one month at 50 ° C. On the other hand, in Comparative Examples 1 to 4 which did not contain any of the components of the present invention, separation was significantly observed, and discoloration was considerably observed except for Comparative Example 3.

Example 9: Emulsion (component) (%)
1. Hydrogenated soybean phospholipid 0.2
2. 1,3-butylene glycol 8.0
3. Glycerin 8.0
4). Behenyl alcohol 0.2
5. Polyoxyethylene (60) hydrogenated castor oil 0.2
6). Cetanol 1.0
7). Batyl alcohol 0.6
8). Polyoxyethylene (20) phytosterol (HLB15.5) 0.3
9. Purified water 30.0
10. Ascorbyl palmitate trisodium 0.2
11. Sodium thiosulfate 0.03
12 Citric acid 3Na 0.1
13. Monohydrogen phosphate Na proper amount14. Purified water remaining amount 15. Edetate disodium 0.02
16. Soybean extract 0.5

(Production method)
A: Ingredients 1 to 3 are heated to 75 ° C. and stirred with a disper mixer at 4000 rpm for 3 minutes.
B: Ingredients 4 to 8 are heated to 75 ° C., added to A, and stirred at 4000 rpm for 3 minutes with a disper mixer.
C: Components 9 and 10 mixed and stirred at room temperature are added to B, and stirred at 4000 rpm for 3 minutes with a disper mixer.
D: Components 11 to 16 were added to C and stirred at 4000 rpm for 3 minutes with a disper mixer to obtain an emulsion.

The emulsion of Example 9 had no problem in both the emulsified state and appearance properties (discoloration) after one month at 50 ° C.

Example 10: Nonwoven fabric impregnated type pack (component) (%)
1. Hydrogenated soybean phospholipid 2.0
2. Propylene glycol 10.0
3. Diglycerin 8.0
4). Stearyl alcohol 0.2
5. Cetanol 0.2
6). Polyoxyethylene (25) Phytostanol (HLB14.5) 1.0
7). Liquid paraffin 1.0
8). Kimyl alcohol 1.0
9. Microcrystalline wax 0.5
10. Purified water 30.0
11. Ascorbyl palmitate trisodium 4.0
12 Sodium pyrosulfite 0.03
13. Citric acid 3Na 0.1
14 Monohydrogen phosphate Na adequate amount15. Purified water remaining amount 16. Edetate disodium 0.01

(Production method)
A: Ingredients 1 to 3 are heated to 75 ° C. and stirred with a disper mixer at 4000 rpm for 3 minutes.
B: Ingredients 4 to 9 are heated to 75 ° C., added to A, and stirred with a dispersion mixer at 4000 rpm for 3 minutes.
C: Components 10 and 11 mixed and stirred at room temperature are added to B and stirred at 4000 rpm for 3 minutes with a disper mixer.
D: Components 12 to 16 were added to C, and a nonwoven solution was impregnated with a stock solution stirred at 4000 rpm for 3 minutes with a disper mixer to obtain a nonwoven fabric-impregnated type pack.

  The nonwoven fabric impregnated type pack material of Example 10 had no problem in both the emulsified state and appearance properties (discoloration) after one month at 50 ° C.

Example 11: Cosmetic liquid (component) (%)
1. Hydrogenated soybean phospholipid 0.2
2. 1,3-butylene glycol 8.0
3. Glycerin 8.0
4). Behenyl alcohol 0.2
5. Conor 5.0
6). Batyl alcohol 0.08
7). Polyoxyethylene (20) phytosterol (HLB15.5) 0.3
8). Squalane 1.0
9. Dipentaglycol neopentyl glycol 0.5
10. Purified water 30.0
11. Ascorbyl palmitate trisodium phosphate 0.04
12 Clara extract 1.0
12 Citric acid 0.1
13. Sodium citrate 0.2
14 Edetate disodium 0.03
15. SIMULGEL EG (Note 1) 1.0
16. Sodium pyrosulfite 0.0005
(Note 1) Sodium acrylate / acryloyldimethyltaurate sodium copolymer (SEPPIC)

(Production method)
A: Ingredients 1 to 3 are heated to 75 ° C. and stirred with a disper mixer at 4000 rpm for 3 minutes.
B: Ingredients 4 to 9 are heated to 75 ° C., added to A, and stirred with a dispersion mixer at 4000 rpm for 3 minutes.
C: Components 10 and 11 mixed and stirred at room temperature are added to B and stirred at 4000 rpm for 3 minutes with a disper mixer.
D: Components 12 to 17 were added to C, and stirred at 4000 rpm for 3 minutes with a disper mixer to obtain a serum.

  The cosmetic liquid of Example 11 had no problem in both the emulsified state and appearance properties (discoloration) after one month at 50 ° C.

Example 12: Cosmetic liquid (component) (%)
1. Hydrogenated soybean phospholipid 4.0
2. 1,3-butylene glycol 8.0
3. Glycerin 8.0
4). Behenyl alcohol 0.2
5. Polyoxyethylene (20) phytosterol (HLB15.5) 0.3
6). Cetanol 5.0
7). Kimyl alcohol 1.5
8). Liquid paraffin 0.7
9. Dipentaglycol neopentyl glycol 0.5
10. Coenzyme Q10 0.01
11. Purified water 30.0
12 Ascorbyl palmitate trisodium 5
13. Arbutin 3.0
14 Citric acid 0.1
15. Sodium citrate 0.2
16. Sodium thiosulfate 0.03
17. Edetate disodium 1.0
18. Sodium carboxymethylcellulose 0.3
19. Purified water remaining

(Production method)
A: Ingredients 1 to 3 are heated to 75 ° C. and stirred with a disper mixer at 4000 rpm for 3 minutes.
B: Ingredients 4 to 10 are heated to 75 ° C., added to A, and stirred with a dispersion mixer at 4000 rpm for 3 minutes.
C: Components 11 and 12 mixed and stirred at room temperature are added to B and stirred at 4000 rpm for 3 minutes with a disper mixer.
D: Components 13 to 19 were added to C, and stirred at 4000 rpm for 3 minutes with a disper mixer to obtain a serum.

  The cosmetic liquid of Example 12 had no problems in both the emulsified state and appearance properties (discoloration) after one month at 50 ° C.

Example 13: Cosmetic liquid (ingredient) (%)
1. Hydrogenated soybean lysophospholipid 0.3
2.1,2-Pentanediol 8.0
3. Glycerin 8.0
4). Stearyl alcohol 0.2
5. Polyoxyethylene (20) phytosterol (HLB15.5) 0.3
6). Cetostearyl alcohol 5.0
7). Batyl alcohol 0.1
8). Vegetable squalane 0.7
9. Triglyceryl 2-ethylhexanoate 0.5
10. Astaxanthin 0.01
11. Purified water 30.0
12 Ascorbyl palmitate trisodium 5
13. Hamamelis extract 3.0
14 Citric acid 0.1
15. Sodium citrate 0.2
16. Sodium thiosulfate 0.001
17. Edetate disodium 0.1
18. Hydroxypropyl methylcellulose 0.3
19. Purified water remaining

A: Ingredients 1 to 3 are heated to 75 ° C. and stirred with a disper mixer at 4000 rpm for 3 minutes.
B: Ingredients 4 to 10 are heated to 75 ° C., added to A, and stirred with a dispersion mixer at 4000 rpm for 3 minutes.
C: Components 11 and 12 mixed and stirred at room temperature are added to B and stirred at 4000 rpm for 3 minutes with a disper mixer.
D: Components 13 to 19 were added to C, and stirred at 4000 rpm for 3 minutes with a disper mixer to obtain a serum.

  The cosmetic liquid of Example 13 had no problems in both the emulsified state and appearance properties (discoloration) after one month at 50 ° C.

Example 14: Cream (ingredient) (%)
1. Hydrogenated soybean phospholipid 2.0
2. Propylene glycol 10.0
3. Diglycerin 8.0
4). Stearyl alcohol 0.2
5. Cetanol 0.2
6). Polyoxyethylene (25) Phytostanol (HLB14.5) 1.5
7). Liquid paraffin 2.0
8). Lauroyl glutamate di (phytosteryl / octyldodecyl) 2.0
9. Dimer linoleic acid (phytosteryl / isostearyl / cetyl / stearyl / behenyl) 1.0
10. Kimyl alcohol 1.0
11. Microcrystalline wax 5.0
12 Purified water 30.0
13. Ascorbyl palmitate trisodium 3.0
14 Sodium pyrosulfite 0.03
15. Citric acid 3Na 0.1
16. Monohydrogen phosphate Na proper amount17. Purified water remaining amount 18. Edetate disodium 0.01
19. Tranexamic acid 2.0
20. Sodium hyaluronate 0.1
21. Xanthan gum 0.5

(Production method)
A: Ingredients 1 to 3 are heated to 75 ° C. and stirred with a disper mixer at 4000 rpm for 3 minutes.
B: Ingredients 4 to 11 are heated to 75 ° C., added to A, and stirred with a dispersion mixer at 4000 rpm for 3 minutes.
C: Components 12 and 13 mixed and stirred at room temperature are added to B and stirred at 4000 rpm for 3 minutes with a disper mixer.
D: Components 14 to 21 were added to C, and stirred at 4000 rpm for 3 minutes with a disper mixer to obtain a cream.

  The cream of Example 14 had no problem in both the emulsified state and appearance properties (discoloration) after one month at 50 ° C.

Example 15: Emulsion (component) (%)
1. Hydrogenated soybean phospholipid 3.0
2. Propylene glycol 12.0
3. Diglycerin 9.0
4). Stearyl alcohol 0.2
5. Cetanol 0.2
6). Polyoxyethylene (25) Phytostanol (HLB14.5) 1.5
7). Squalane 2.0
8). Dimethicone 0.5
9. Cetyl ethylhexanoate 1.0
10. Batyl alcohol 1.5
11. Candelilla wax 1.0
12 Purified water 30.0
13. Ascorbyl palmitate trisodium 3.0
14 Sodium pyrosulfite 0.02
15. Citric acid 3Na 0.1
16. Monohydrogen phosphate Na proper amount17. Purified water remaining amount 18. Edetate disodium 0.02
19. L-ascorbic acid 2-glucoside 2.0
20. Sodium hydroxide 0.25
21. Xanthan gum 0.5
22. Water-soluble collagen 0.005

(Production method)
A: Ingredients 1 to 3 are heated to 75 ° C. and stirred with a disper mixer at 4000 rpm for 3 minutes.
B: Ingredients 4 to 11 are heated to 75 ° C., added to A, and stirred with a dispersion mixer at 4000 rpm for 3 minutes.
C: Components 12 and 13 mixed and stirred at room temperature are added to B and stirred at 4000 rpm for 3 minutes with a disper mixer.
D: Ingredients 14 to 22 were added to C, and stirred at 4000 rpm for 3 minutes with a disper mixer to obtain an emulsion.

  The emulsion of Example 15 had no problem in both the emulsified state and appearance properties (discoloration) after one month at 50 ° C.

Example 16: Daytime serum (component) (%)
1. Hydrogenated soybean phospholipid 1.0
2. Propylene glycol 8.0
3. Diglycerin 7.0
4). Behenyl alcohol 0.2
5. Cetanol 0.3
6). Polyoxyethylene (20) phytosterol (HLB15.5) 1.5
7). Octyl salicylate 1.0
8). Ethylhexyl methoxycinnamate 8.0
9. Diethylaminohydroxybenzoyl hexyl benzoate 1.0
10. Bisethylhexyloxyphenol methoxyphenyltriazine 1.0
11. t-Butylmethoxydibenzoylmethane 0.5
12 Octyl rearzone 0.5
13. Octocrylene 1.0
14 Polysilicone-15 1.0
15. Kimyl alcohol 0.8
16. Purified water 30.0
17. Ascorbyl palmitate trisodium 3.0
18. Sodium pyrosulfite 0.0003
19. Citric acid 3Na 0.1
20. Monohydrogen phosphate Na proper amount21. Purified water remaining amount 22. Edetate disodium 0.03
23. Methylenebisbenzotriazolyltetramethylbutylphenol 0.5
24. Decyl glucoside 0.075
25. Propylene glycol 0.004
26. Xanthan gum 0.7
27. Phenylbenzimidazolesulfonic acid 1.0
28. Triethanolamine 0.6

(Production method)
A: Ingredients 1 to 3 are heated to 75 ° C. and stirred with a disper mixer at 4000 rpm for 3 minutes.
B: Ingredients 4 to 15 are heated to 75 ° C., added to A, and stirred with a disper mixer at 4000 rpm for 3 minutes.
C: Components 16 and 17 mixed and stirred at room temperature are added to B, and stirred at 4000 rpm for 3 minutes with a disper mixer.
D: Components 18 to 28 were added to C, and stirred at 4000 rpm for 3 minutes with a disper mixer to obtain a cream.

  The daytime cosmetic liquid of Example 16 had no problem in both the emulsified state and appearance properties (discoloration) after one month at 50 ° C.

Claims (8)

The following components (a) to (f);
(A) Phospholipid and / or lysophospholipid (b) Monoalkyl glyceryl ether (c) Sulfur-containing antioxidant compound selected from pyrosulfite, sulfite, bisulfite, dithionate and thiosulfate (d) Chelating agent (e) Higher fatty acid ester salt of ascorbic acid-2-phosphate (f) An oil-in-water emulsion composition containing a higher alcohol that is solid at 25 ° C.   The oil-in-water emulsion composition according to claim 1, wherein the component (b) is monostearyl glyceryl ether.   The oil-in-water emulsion composition according to claim 1 or 2, wherein the component (d) is selected from edetate disodium and diethylenetriaminepentaacetic acid pentasodium.   The component (f) is one or more selected from higher alcohols having 16 to 18 carbon atoms and one or more selected from higher alcohols having 20 to 24 carbon atoms. The oil-in-water emulsion composition according to any one of the above.   Furthermore, the oil-in-water emulsion composition of any one of Claims 1-4 with which the POE cholesteryl ether and / or POE phytosteryl ether whose HLB values are 7-10 are mix | blended as a component (g).   The oil-in-water emulsion composition according to any one of claims 1 to 5, which is a cosmetic or an external preparation for skin.   Cosmetics or a skin external preparation by which the oil-in-water emulsion composition of any one of Claims 1-5 was mix | blended.   The manufacturing method of cosmetics or a skin external preparation including the process of preparing the oil-in-water emulsion composition of any one of Claims 1-5, and adding the prepared oil-in-water emulsion composition.