JP6580018B2 - Transparent lotion - Google Patents

Description

  The present invention relates to a transparent lotion.

  Astaxanthin is known to have a high singlet oxygen scavenging ability and to have an effect of suppressing skin photoaging caused by singlet oxygen, and is often used in skin lotions. Astaxanthin has excellent antioxidant ability, but its own stability is poor. Therefore, when astaxanthin is blended with lotion, it has been attempted to improve stability by using it together with an antioxidant. As an antioxidant for stabilizing astaxanthin, an ionic antioxidant such as ascorbic acid phosphate is often used.

By the way, in general, a lotion requires a moisturizing feeling as an effect when applied to the skin. In a transparent lotion, it is known to use glycerin as a moisturizing agent in order to obtain a good moisturizing feeling without impairing transparency.
For example, Patent Document 1 discloses a skin care lotion containing astaxanthin, an ionic antioxidant, glycerin and the like as a lotion containing glycerin.

Japanese Patent No. 5046756

By the way, in transparent lotion containing astaxanthin, when a certain amount or more of an ionic antioxidant is included for improving the stability of astaxanthin, when the transparent lotion is applied to the skin as the salt concentration increases, There may be a sticky feeling when drying.
In addition, if a certain amount or more of glycerin is contained in a transparent lotion to obtain a good moisturizing feeling without impairing the transparency, a sticky feeling during drying may occur as the moisturizing feeling is improved.

For example, the lotion disclosed in Patent Document 1 contains a large amount of an ionic antioxidant for improving the stability of astaxanthin, or a large amount of glycerin for obtaining a good moisturizing feeling. It is assumed that a sticky feeling occurs.
That is, the transparent lotion containing astaxanthin, an ionic antioxidant, and glycerin is excellent in the stability of astaxanthin and has an effect of obtaining a good moisturizing feeling when applied to the skin. It is considered difficult to suppress the sticky feeling at the time of drying that may occur when applied to the skin.

  The present invention has been made in view of the circumstances as described above, and has excellent stability of astaxanthin, and when applied to the skin, a good moisturizing feeling is obtained, and the sticky feeling at the time of drying is suppressed. The object is to provide lotion.

Specific means for solving the above problems include the following modes.
<1> A transparent lotion containing (i) to (vi).
(I) Glycerin having a content of 2.3% to 3.7% by mass with respect to the total amount of the transparent skin lotion (ii) A content of 2.3% to 3.7% by mass with respect to the total amount of the transparent skin toner. Polyethylene glycol (iii) Astaxanthin (iv) The content of the clear skin lotion is 0.1% by mass to 3% by mass, and at least one selected from the group consisting of ascorbic acid, ascorbic acid derivatives, and salts thereof Seed compound (v) Ferulic acid (vi) Water having a content of 50% by mass or more based on the total amount of the transparent skin lotion

<2> The transparent lotion according to <1>, wherein the ratio of the glycerin content to the polyethylene glycol content in the transparent lotion is 0.6 to 1.2 on a mass basis.
<3> The transparent lotion according to <1> or <2>, which has a pH of 5.4 to 6.0.
<4> The transparent lotion according to any one of <1> to <3>, wherein the astaxanthin is krill-derived astaxanthin.
<5> At least one compound selected from the group consisting of ascorbic acid, ascorbic acid derivatives, and salts thereof is ascorbic acid, magnesium ascorbate phosphate, sodium ascorbate phosphate, magnesium ascorbate sulfate, The transparent lotion according to any one of <1> to <4>, which is at least one compound selected from the group consisting of sodium ascorbate sulfate sodium and sodium ascorbyl palmitate.

  ADVANTAGE OF THE INVENTION According to this invention, it is excellent in the stability of astaxanthin, When it applies to skin, a favorable moisturizing feeling is obtained and the transparent lotion in which the sticky feeling at the time of drying was suppressed can be provided.

It is a figure which shows the evaluation result of tack property. It is a figure which shows the correlation with a moisturizing feeling and the stickiness feeling at the time of drying when the transparent lotion of an Example and a comparative example is applied to skin. It is a figure which shows the verification result of the oxidation inhibitory effect of the fatty acid by ferulic acid.

  Hereinafter, specific embodiments of the present invention will be described in detail. However, the present invention is not limited to the following embodiments, and can be implemented with appropriate modifications within the scope of the object of the present invention.

In the present specification, a numerical range indicated using “to” means a range including the numerical values described before and after “to” as a minimum value and a maximum value, respectively.
In the present specification, the amount of each component in the transparent skin lotion is the amount of the plurality of types of substances present in the transparent skin lotion unless otherwise specified, when there are multiple types of substances corresponding to each component in the transparent skin lotion. It means the total amount.

In the present specification, the “aqueous phase” used when obtaining the emulsion is used as a term for the “oil phase” regardless of the type of the solvent. The aqueous phase is composed of water and water-soluble components.
The “water-soluble component” means a component having a solubility in water at 25 ° C. of 1% by mass or more, that is, 10 g / L or more.
In the present specification, the “oil component” means a component having a solubility in water at 25 ° C. of less than 1% by mass and generally used as an oil component in the cosmetic field.

[Transparent lotion]
The transparent lotion of the present invention has (i) glycerin whose content with respect to the total amount of the transparent lotion is 2.3% by mass to 3.7% by mass, and (ii) a content with respect to the total amount of the transparent lotion. Polyethylene glycol that is 3% by mass to 3.7% by mass, (iii) Astaxanthin, and (iv) Content of 0.1% by mass to 3% by mass with respect to the total amount of transparent lotion, ascorbic acid, ascorbic acid Derivatives and at least one compound selected from the group consisting of salts thereof (hereinafter, collectively referred to as “ascorbic acid compound” as appropriate), (v) ferulic acid, and (vi) inclusion with respect to the total amount of the clear skin lotion And water whose amount is 50% by mass or more.

The transparent lotion of the present invention contains astaxanthin. In transparent lotions containing astaxanthin, if a certain amount or more of an ionic antioxidant is included to improve the stability of astaxanthin, when the skin lotion is applied to the skin as the salt concentration increases, A sticky feeling may occur.
In the transparent skin lotion of the present invention, the content of the ascorbic acid compound is suppressed to a specific ratio, and the ascorbic acid compound and ferulic acid are used in combination to suppress the sticky feeling during drying that may occur when applied to the skin. Meanwhile, astaxanthin can be stabilized.

The transparent lotion of the present invention contains glycerin. In the case of a transparent lotion, if a certain amount or more of glycerin is contained in order to obtain a good moisturizing feeling without impairing the transparency, a sticky feeling at the time of drying may occur as the moisturizing feeling is improved.
The transparent skin lotion of the present invention is excellent in moisturizing power among moisturizers used in skin lotions, but glycerin that tends to be sticky, and polyethylene glycol that is less moisturized than glycerin but hardly sticky. By using together with specific content, a favorable moisturizing feeling can be obtained, suppressing the sticky feeling at the time of drying which may arise when it applies to skin.

Although glycerin and polyethylene glycol are different in degree, when the content in the transparent skin lotion increases, the sticky feeling at the time of drying tends to increase as the moisturizing feeling improves.
According to the study by the present inventors, when glycerin and polyethylene glycol are used in combination, it is possible to improve the moisturizing feeling without increasing the sticky feeling at the time of drying, which is different from the behavior of each of them alone. It became clear that there was a combination of quantities. Such knowledge has not been obtained in the past.

  In the present specification, “transparent lotion” means a lotion that exhibits a transparent appearance. Absorbance is used as an index of transparency. In the case of the transparent lotion of the present invention, the term “transparent” means that the absorbance of light having a wavelength of 625 nm, which is an absorption wavelength of astaxanthin, measured using a spectrophotometer and a cell having an optical path length of 5 mm is 0.3 or less. 0.2 or less is preferable. As a spectrophotometer, U-3310 of Hitachi, Ltd. is mentioned, for example.

The transparent lotion of the present invention is in the form of an emulsion (hereinafter also referred to as “astaxanthin emulsion”) in which an oil component such as astaxanthin is dispersed in an aqueous phase in order to satisfy the transparency (absorbance). It is preferable to contain.
The content of the oil component in the transparent lotion of the present invention varies depending on the size of the emulsified particles dispersed in the aqueous phase, but is 3% by mass or less based on the total amount of the transparent lotion in order to satisfy the above-described absorbance. It is preferably 2% by mass or less.

  Hereinafter, the components contained in the transparent lotion of the present invention will be described in detail.

<Glycerin>
The transparent lotion of the present invention contains glycerin at a content of 2.3% by mass to 3.7% by mass with respect to the total amount of the transparent lotion.
Glycerin is frequently used as a moisturizer because it is transparent, has a large amount of water retention, is highly safe, and has excellent applicability to the skin. In the transparent lotion of the present invention, glycerin contributes to an improvement in moisturizing feeling when applied to the skin.

  Content of glycerol is 2.3 mass%-3.7 mass% with respect to the whole quantity of transparent lotion, It is preferable that it is 2.5 mass%-3.7 mass%, and 2.5 mass. From the viewpoint of a better balance between improvement in moisturizing feeling and suppression of stickiness during drying when applied to the skin, it is more preferably from 2.7% by mass to 3%. More preferably, it is 3% by mass.

<Polyethylene glycol>
The transparent lotion of the present invention contains polyethylene glycol (PEG) at a content of 2.3% by mass to 3.7% by mass with respect to the total amount of the transparent lotion.
Polyethylene glycol is often used as a humectant, like glycerin described above. In addition, although the effect as a moisturizer of polyethylene glycol in transparent lotion is inferior to glycerin, the stickiness at the time of drying felt when applied to the skin is less than that of glycerin.
In the transparent cosmetic composition of the present invention, in order to improve the moisturizing feeling when applied to the skin, a specific amount of glycerin is used in combination with a specific amount of polyethylene glycol, thereby suppressing an increase in stickiness during drying. However, the moisturizing feeling can be improved.

The average molecular weight of polyethylene glycol is not particularly limited. For example, from the viewpoint of moisturizing feeling when applied to the skin, it is preferably 800 or more, more preferably 1000 or more, and further preferably 1300 or more. preferable.
In addition, the average molecular weight of polyethylene glycol is preferably 10,000 or less, more preferably 8000 or less, more preferably 2000 or less, from the viewpoint of handleability in consideration of, for example, solubility in water and viscosity change at the time of blending. More preferably, it is as follows.

  The transparent lotion of the present invention may contain polyethylene glycol alone or in combination of two or more.

A commercially available product can be used as the polyethylene glycol.
Examples of commercially available products of polyethylene glycol include PEG # 1000 (trade name, standard component name: polyethylene glycol 1000, average molecular weight: 1000) of NOF Corporation, PEG # 1540 (trade name, standard component name: polyethylene glycol). 1540, average molecular weight: 1540), PEG # 2000 (trade name, standard component name: polyethylene glycol 2000, average molecular weight: 2000), PEG # 4000 (trade name, standard component name: polyethylene glycol 4000, average molecular weight: 3100), PEG # 6000 (trade name, standard component name: polyethylene glycol 6000, average molecular weight: 8800), etc. Toho Polyethylene Glycol 1000 (trade name, standard component name: polyethylene glycol 1000, average molecular weight: 1000) from Toho Chemical Industry Co., Ltd. Etc., and the like.

  The content of polyethylene glycol is 2.3% by mass to 3.7% by mass, preferably 2.5% by mass to 3.7% by mass, based on the total amount of the transparent lotion, From the viewpoint of a better balance between improvement in moisturizing feeling and suppression of stickiness during drying when applied to the skin, it is more preferably 2.7% by mass to 3.5% by mass. It is still more preferable that it is 3.3 mass%.

  The ratio of the content of glycerin to the content of polyethylene glycol in the transparent skin lotion (content of glycerin / content of polyethylene glycol) is not particularly limited. For example, the improvement in moisturizing feeling when applied to the skin From the viewpoint of a better balance with suppression of stickiness during drying, it is preferably 0.6 to 1.2, more preferably 0.7 to 1.2 on a mass basis, and More preferably, it is 8 to 1.2.

  As a preferred embodiment, the average molecular weight of polyethylene glycol is 1000 to 2000, and the ratio of the content of glycerin to the content of polyethylene glycol in the transparent lotion (content of glycerin / content of polyethylene glycol) is The aspect which is 0.7-1.2 on a mass basis is mentioned.

<Astaxanthin>
The transparent lotion of the present invention contains astaxanthin.
Astaxanthin encompasses at least one of derivatives such as astaxanthin and esters of astaxanthin. In the present invention, astaxanthin and its derivatives are collectively referred to as “astaxanthin” unless otherwise specified.

As astaxanthin, in addition to astaxanthin derived from natural products such as plants, algae, crustaceans, and bacteria, a synthetic product of astaxanthin obtained according to a conventional method can also be used.
Astaxanthin can be extracted from cultures such as red yeast Phaffia, green alga Hematococcus, marine bacteria, and krill.
In the transparent lotion of the present invention, astaxanthin may be contained as an astaxanthin-containing oil obtained as a natural product containing astaxanthin or a separated or extract from the culture.
Astaxanthin or astaxanthin-containing oil is, from the viewpoint of quality and productivity, an extract from Haematococcus algae (hereinafter referred to as “Hematococcus alga extract”) or an extract from krill (hereinafter referred to as “krill extraction”). Astaxanthin derived from a krill extract is particularly preferable.
Astaxanthin derived from the krill extract (krill-derived astaxanthin) can be used not only for lotions classified as cosmetics but also for lotions classified as quasi drugs.

A commercially available product can be used as astaxanthin.
Examples of commercially available products of Haematococcus alga extract include ASTOTS (registered trademark) -S, ASTOTS (registered trademark) -ST, ASTOTS (registered trademark) -2.5 O, and ASTOTS (registered trademark) of FUJIFILM Corporation. ) -5 O, ASTOTS (registered trademark) -10 O, etc., Fuji Chemical Industry Co., Ltd. Asteril (registered trademark) Oil 50F, Asteryl (registered trademark) Oil 5F, etc., Toyo Enzyme Chemical Co., Ltd. Registered trademark) SCE7.
Examples of commercially available krill extract include Astax-ST (trade name) of Marine Daio Co., Ltd.

  The content of astaxanthin in the astaxanthin-containing oil is preferably 0.001% by mass to 50% by mass, and preferably 0.01% by mass to 25% by mass from the viewpoint of handling during production of the transparent skin lotion. Is more preferable.

  The content of astaxanthin in the transparent lotion can be determined from the expression of singlet oxygen scavenging ability (antioxidant effect), the appearance (transparency) and the like. For example, the content of astaxanthin is preferably 0.000001% by mass to 0.01% by mass (0.01 ppm to 100ppm), and 0.000005% by mass to 0.0075% with respect to the total amount of the transparent lotion. It is more preferable that it is mass% (0.05 ppm-75 ppm), and it is still more preferable that it is 0.0001 mass%-0.005 mass% (1 ppm-50 ppm).

The content of astaxanthin in the transparent lotion of the present invention is not particularly limited. For example, astaxanthin can be blended at a high concentration, astaxanthin can be stably contained in the clear lotion, and the transparency of the lotion. Astaxanthin is preferably contained in the emulsified particles dispersed in the aqueous phase.
In particular, from the viewpoint of ease of production and the like, the transparent lotion of the present invention preferably contains astaxanthin in the form of an emulsion (astaxanthin emulsion) in which oily components including astaxanthin are dispersed in an aqueous phase.
Hereinafter, the components contained in the astaxanthin emulsion will be described.

(Astaxanthin emulsion)
-Oily components other than astaxanthin-
The astaxanthin emulsion preferably contains an oil component other than astaxanthin.
The oil component is preferably an oil component that is liquid at 25 ° C. Here, “liquid at 25 ° C.” means that the melting point or softening point at normal pressure is less than 25 ° C.
Examples of the oil component include fats and oils, hydrocarbons, waxes, higher fatty acids, higher fatty acid esters, and the like. Among these, liquid components at 25 ° C. are preferable.
The astaxanthin emulsion may contain oily components other than astaxanthin alone or in combination of two or more.

As fats and oils, avocado oil, almond oil, olive oil, cacao oil, cow oil, sesame oil, wheat germ oil, safflower oil, shea butter, turtle oil, coconut oil, persic oil, castor oil, grape oil, macadamia nut oil, mink oil , Egg yolk oil, palm oil, owl, rosehip oil, soybean oil, hardened oil (hardened castor oil, hardened palm oil, hardened cocoa oil, hardened turtle oil, hardened mink oil, etc.), lanolin (wool fat), medium chain fatty acid Examples include triglycerides (tri (caprylic acid / capric acid) glyceryl, etc.), tocopherols (mixed tocopherols) extracted from vegetable oils and fats, tocotrienols, and the like.
Examples of the hydrocarbon include liquid paraffin, isoparaffin, petrolatum, paraffin wax, ceresin, microcrystalline wax, squalane and the like.
Examples of the wax include carnauba wax, candelilla wax, montan wax, beeswax, lanolin, whale wax, jojoba oil, orange luffy oil, hydrogenated lanolin, hydrogenated jojoba oil, hydrogenated carnauba wax and the like.
The higher fatty acid is not particularly limited as long as it has 12 or more carbon atoms. Lauric acid, myristic acid, palmitic acid, stearic acid, oleic acid, behenic acid, oxystearic acid, linoleic acid, lanolin fatty acid, isopalmitin Examples include acids, isostearic acid, isotridecanoic acid and the like.

Examples of the higher fatty acid ester include an ester of a higher fatty acid and a lower alcohol, an ester of a higher fatty acid and an intermediate or higher alcohol, an ester of a higher fatty acid and a polyhydric alcohol, and a cyclic alcohol fatty acid ester.
Examples of esters of higher fatty acids and lower (2 to 4 carbon atoms) alcohols include ethyl linoleate, isopropyl myristate, and lanolin fatty acid isopropyl.
Examples of esters of higher fatty acids with intermediate (5 to 11 carbon atoms) or higher (12 or more carbon atoms) alcohols are hexyl laurate, myristyl myristate, cetyl myristate, octyldodecyl myristate, decyl oleate, oleic acid Examples thereof include octyldodecyl and cetyl palmitate.
Examples of the ester of a higher fatty acid and a polyhydric alcohol include glyceryl trimyristate, propylene glycol dioleate, and glyceryl triisostearate.
Examples of the cyclic alcohol fatty acid ester include cholesteryl stearate, cholesteryl isostearate, and cholesteryl 12-hydroxystearate.

  Among these, as the oil component, tri (caprylic acid / capric acid) glyceryl and tocopherol are preferable from the viewpoint of excellent compatibility with astaxanthin and stability, and tocopherol and tri (caprylic acid / capric acid) glyceryl are used in combination. It is preferable to do.

  The content of the oil component in the astaxanthin emulsion is not particularly limited. For example, from the viewpoint of stabilizing the dispersion of the astaxanthin emulsion, it is preferably 1 to 150 times the mass of the astaxanthin, More preferably, it is 5 times or more and 50 times or less.

-Lecithin-
The astaxanthin emulsion preferably contains lecithin.
Examples of lecithin include various lecithins derived from plants such as soybean, corn, peanut, rapeseed and wheat, animals such as egg yolk and cattle, and microorganisms such as Escherichia coli.
Specific examples of lecithin include phosphatidic acid, phosphatidylglycerol, phosphatidylinositol, phosphatidylethanolamine, phosphatidylmethylethanolamine, phosphatidylcholine, phosphatidylserine, bisphosphatidic acid, diphosphatidylglycerol (cardiolipin) and other glycerolecithins, sphingomyelin, etc. Sphingolecithin and the like.

  As lecithin, in addition to lecithin generally called high-purity lecithin with a lecithin purity of 80% or more (more preferably 90% or more), hydrogenated lecithin, enzymatically decomposed lecithin, enzymatically decomposed hydrogenated lecithin, hydroxylecithin, etc. are used. You can also

  The astaxanthin emulsion may contain lecithin alone or in combination of two or more.

  In the astaxanthin emulsion, the content of lecithin is preferably 0.1 to 10 times, more preferably 0.5 to 8 times the mass of astaxanthin. More preferably, the amount is 1 to 5 times.

  The content of lecithin in the transparent lotion of the present invention is preferably 0.0000001% by mass or more and 0.1% by mass or less, based on the total amount of the transparent lotion, from the viewpoint of preventing coloring over time. It is more preferable that it is 00015 mass% or more and 0.1 mass% or less.

-Water-soluble emulsifier-
The astaxanthin emulsion preferably contains a water-soluble emulsifier.
A water-soluble emulsifier is contained in the water-soluble component which comprises the aqueous phase of an astaxanthin emulsion.
The water-soluble emulsifier is not particularly limited as long as it is an emulsifier having a solubility in water at 25 ° C. of 1% by mass or more (10 g / L or more). For example, the water-soluble emulsifier is preferably a nonionic surfactant, and more preferably a nonionic surfactant having a HLB (Hydrophile Lipophile Balance) of 10 or more (preferably 12 or more) from the viewpoint of obtaining sufficient emulsifying power.

  HLB means the hydrophilic-hydrophobic balance usually used in the field of surfactants. The HLB can be calculated using a commonly used calculation formula, for example, the Kawakami formula. Kawakami's formula is shown below.

HLB = 7 + 11.7log (Mw / Mo)
Here, Mw represents the molecular weight of the hydrophilic group, and Mo represents the molecular weight of the hydrophobic group.

The HLB may adopt a numerical value described in a catalog or the like.
Further, as can be seen from the above formula, an emulsifier having an arbitrary HLB value can be obtained by utilizing the additivity of HLB.

Examples of nonionic surfactants include organic acid monoglycerides, polyglycerin fatty acid esters, propylene glycol fatty acid esters, polyglycerin condensed ricinoleic acid esters, sorbitan fatty acid esters, and sucrose fatty acid esters.
Among these, as the nonionic surfactant, at least one selected from the group consisting of polyglycerin fatty acid ester, sorbitan fatty acid ester, and sucrose fatty acid ester is preferable, and polyglycerin fatty acid ester and sucrose fatty acid ester are used in combination. It is particularly preferred.

The polyglycerol fatty acid ester has an average degree of polymerization of 2 or more, preferably 6 to 15, more preferably 8 to 10 and a fatty acid having 8 to 18 carbon atoms such as caprylic acid, capric acid, lauric acid, myristic. Examples thereof include esters with acids, palmitic acid, stearic acid, oleic acid, linoleic acid and the like.
Preferred examples of polyglycerol fatty acid esters include hexaglycerol monooleate, hexaglycerol monostearate, hexaglycerol monopalmitate, hexaglycerol monomyristate, hexaglycerol monolaurate, decaglycerol monooleate , Decaglycerin monostearic acid ester, decaglycerin monopalmitic acid ester, decaglycerin monomyristic acid ester, decaglycerin monolauric acid ester and the like.
A commercially available product can be used as the polyglycerol fatty acid ester.

As a sucrose fatty acid ester, those having 12 or more carbon atoms of fatty acids are preferable, and those having 12 to 20 carbon atoms are more preferable.
Preferred examples of sucrose fatty acid esters include sucrose dioleate, sucrose distearate, sucrose dipalmitate, sucrose dimyristic ester, sucrose dilaurate, sucrose monooleate, sucrose Examples thereof include sugar monostearate, sucrose monopalmitate, sucrose monomyristate, and sucrose monolaurate.
A commercial item can be used as sucrose fatty acid ester.

  The astaxanthin emulsion may contain a water-soluble emulsifier singly or in combination of two or more.

  The content of the water-soluble emulsifier in the astaxanthin emulsion is 1 time or more with respect to the mass of astaxanthin because it is easy to form fine emulsified particles, can stabilize the astaxanthin emulsion, and can suppress foaming. The amount is preferably 100 times or less, more preferably 2 times or more and 50 times or less, and still more preferably 5 times or more and 25 times or less.

  The content of the water-soluble emulsifier in the transparent lotion of the present invention is from 0.0001% by mass to 2% by mass with respect to the total amount of the transparent lotion, from the viewpoint of preventing irritation to the skin and suppressing foaming. Preferably, it is 0.001 mass% or more and 0.5 mass% or less.

  The transparent lotion of the present invention preferably contains at least one selected from the group consisting of lecithin and polyglycerin fatty acid ester, from the viewpoint of stability of the astaxanthin emulsion, and contains both lecithin and polyglycerin fatty acid ester. It is more preferable to use one or more.

-Water-
The astaxanthin emulsion preferably contains water.
The water used for the astaxanthin emulsion is the same water as that constituting the transparent lotion, which will be described later.
Water becomes one of the components constituting the aqueous phase.

  In the astaxanthin emulsion, the content of water is preferably 5 times or more and 1000 times or less, more preferably 10 times or more and 800 times or less, more preferably 20 times the amount of astaxanthin. More preferably, the amount is 100 times or less.

-Polyhydric alcohol-
The astaxanthin emulsion preferably contains a polyhydric alcohol as one of the water-soluble components constituting the aqueous phase.
Examples of the polyhydric alcohol include glycerin and divalent alcohol having 6 or less carbon atoms, which will be described later.
Among these, glycerin is preferably used because it reduces the average particle size of the emulsified particles containing astaxanthin and easily keeps the particle size stable for a long period of time while keeping the particle size small.

  In the astaxanthin emulsion, the content of the polyhydric alcohol is preferably 5 times or more and 1000 times or less, more preferably 10 times or more and 800 times or less, relative to the mass of astaxanthin, More preferably, the amount is not less than double amount and not more than 200 times amount.

<Ascorbic acid, ascorbic acid derivatives, and salts thereof>
The transparent lotion of the present invention contains at least one compound selected from the group consisting of ascorbic acid, ascorbic acid derivatives, and salts thereof in an amount of 0.1% by mass to 3% by mass with respect to the total amount of the transparent lotion. Including by content.
In the transparent lotion of the present invention, at least one compound selected from the group consisting of ascorbic acid, ascorbic acid derivatives, and salts thereof, together with ferulic acid described later, the antioxidant ability of ascorbic acid itself, or transparent makeup Astaxanthin can be stabilized by the antioxidant ability of ascorbic acid produced over time in water.

  In the present specification, the “ascorbic acid derivative” refers to a compound in which ascorbic acid is generated by decomposition caused by pH, heat, light, oxidation, enzyme, and the like. The ascorbic acid derivative is preferably water-soluble.

Examples of the salt of ascorbic acid include sodium ascorbate, potassium ascorbate, and calcium ascorbate.
Ascorbic acid derivatives and salts thereof include ascorbic acid phosphate and its salts (ascorbic acid magnesium phosphate (APM), ascorbic acid sodium phosphate, etc.), ascorbic acid sulfate and its salts (ascorbic acid magnesium sulfate) , Sodium ascorbyl sulfate, etc.), ascorbyl palmitate and its salts (sodium ascorbyl phosphate, etc.) and the like.

As at least one compound selected from the group consisting of ascorbic acid, ascorbic acid derivatives, and salts thereof, from the viewpoint of the stability of astaxanthin, ascorbic acid and its salt, ascorbic acid phosphate and its salt, It is preferably at least one compound selected from the group consisting of ascorbyl palmitate and its salt, ascorbic acid, magnesium ascorbate phosphate, sodium ascorbate phosphate, magnesium ascorbate sulfate More preferably, it is at least one compound selected from the group consisting of sodium ascorbate sulfate, and sodium ascorbyl palmitate.
Furthermore, as at least one compound selected from the group consisting of ascorbic acid, ascorbic acid derivatives, and salts thereof from the viewpoint of stability over time (for example, suppression of coloring over time) and generation of caramel-like odor, It is preferably at least one compound selected from the group consisting of magnesium ascorbate phosphate, sodium ascorbate phosphate sodium, and sodium ascorbyl palmitate.

In addition, the cosmetic ingredient display name of ascorbic acid phosphate magnesium is “ascorbyl phosphate Mg”, and the quasi-drug component display name is “L-ascorbyl magnesium phosphate”.
The cosmetic ingredient display name of sodium ascorbic acid phosphate ester is “ascorbyl phosphate Na”, and the quasi-drug component display name is “L-ascorbyl sodium phosphate”.
The cosmetic ingredient labeling name of sodium ascorbyl palmitate is “3Na ascorbyl phosphate palmitate”.

  The transparent lotion of the present invention may contain a compound selected from the group consisting of ascorbic acid, ascorbic acid derivatives, and salts thereof singly or in combination of two or more.

  The content of at least one compound selected from the group consisting of ascorbic acid, ascorbic acid derivatives, and salts thereof is 0.1% by mass to the total amount of the transparent lotion from the viewpoint of the stability of astaxanthin. From the viewpoint of suppressing precipitation of these compounds over time at low temperatures, it is preferably 0.1% by mass to 2% by mass, and preferably 0.1% by mass to 1% by mass. More preferably, it is still more preferable that it is 0.15 mass%-1 mass%.

<Ferula acid>
The transparent lotion of the present invention contains ferulic acid.
Ferulic acid is an organic compound present in the cell walls of plants and has an antioxidant ability.
In the transparent lotion of the present invention, ferulic acid contributes to the stability of astaxanthin together with the above ascorbic acid compound.
The ascorbic acid compound described above also contributes to the stability of astaxanthin. However, in the lotion containing astaxanthin, for example, when an ionic antioxidant such as a salt of ascorbic acid phosphate is frequently used, it is applied to the skin. Feel sticky.
In the transparent skin lotion of the present invention, the stability of astaxanthin can be ensured while suppressing stickiness when dried by applying ferulic acid and a specific amount of an ascorbic acid compound in combination to the skin. .

Moreover, ferulic acid contributes to the oxidation suppression of the fatty acid contained in the krill-derived astaxanthin.
Krill-derived astaxanthin has an odor derived from fatty acids contained in krill as a raw material. This odor is exacerbated by fatty acid oxidation over time. Therefore, krill-derived astaxanthin may be difficult to use as astaxanthin to be blended into the skin lotion.
In the transparent lotion of the present invention containing ferulic acid, since ferulic acid suppresses the oxidation of fatty acid, even astaxanthin derived from krill can be used without any problem.

Moreover, ferulic acid can suppress oxidation of fatty acids other than fatty acids derived from astaxanthin.
Fatty acids contained in phospholipids constituting cell membranes are oxidized under the influence of active oxygen generated by ultraviolet rays and the like to generate lipid peroxides, and further, acrolein, 4 through the generated lipid peroxides. -It is known that metabolites such as hydroxynonenal are produced. Since these metabolites have an aldehyde group, they bind to constituent proteins such as collagen and elastin in the skin and denature the proteins. When such protein denaturation occurs in the skin, wrinkles, sagging, and skin color changes are caused in the skin.
Ferulic acid is a compound that exhibits amphipathic properties and has good affinity with fatty acids. Therefore, by applying the transparent lotion of the present invention containing ferulic acid to the skin, the effect of suppressing the oxidation of fatty acids as described above, particularly the change in skin color caused by the generation of the above metabolites in the dermis (so-called dermal It can be expected to reduce yellowing.

The content of ferulic acid is not particularly limited. For example, from the viewpoint of the stability of astaxanthin, it is preferably 0.000001% by mass or more and 0.000007% by mass or more with respect to the total amount of the transparent lotion. More preferably, it is 0.00001% by mass or more.
Moreover, it is preferable that content of ferulic acid is 1 mass% or less with respect to the whole quantity of transparent lotion from a coloring viewpoint, for example.

<Water>
The transparent lotion of the present invention contains water.
There is no restriction | limiting in particular as water, Natural water, purified water, distilled water, ion-exchange water, pure water, ultrapure water (Milli-Q water etc.), etc. can be used. In addition, Milli-Q water is the ultrapure water obtained with the Milli-Q water manufacturing apparatus of Merck Co., Ltd. Merck Millipore.
The water contained in the transparent lotion of the present invention is preferably purified water, distilled water, ion exchange water, pure water, or ultrapure water from the viewpoint of few impurities.

The water content in the transparent lotion of the present invention is 50% by mass or more, preferably 55% by mass or more, more preferably 60% by mass or more, based on the total amount of the transparent lotion. More preferably, it is 65 mass% or more.
Moreover, it is preferable that content of the water in the transparent lotion of this invention is 85 mass% or less with respect to the whole quantity of a transparent lotion from a viewpoint of provision of a favorable moisturizing feeling.
The content of water described above means the total content of water contained in the transparent lotion, and includes water used for the preparation of the aforementioned astaxanthin emulsion.

<Other ingredients>
The transparent lotion of the present invention may contain components other than the above-described components as necessary within a range not impairing the effects of the present invention.
Examples of other components include divalent alcohols and various additives.

(Divalent alcohol)
The transparent skin lotion of the present invention preferably contains a divalent alcohol having 6 or less carbon atoms from the viewpoint of improving moisturizing feeling and suppressing stickiness.
Examples of the divalent alcohol having 6 or less carbon atoms include 1,3-butylene glycol (BG), propylene glycol, pentylene glycol, 1,2-hexanediol, dipropylene glycol (DPG), and the like.
Among these, the divalent alcohol having 6 or less carbon atoms is preferably at least one selected from 1,3-butylene glycol (BG) and dipropylene glycol (DPG) from the viewpoint of irritation to the skin.

  When the transparent lotion of the present invention contains a divalent alcohol having 6 or less carbon atoms, it may contain one or more divalent alcohols having 6 or less carbon atoms alone or in combination.

  When the transparent lotion of the present invention contains a dihydric alcohol having 6 or less carbon atoms, the content of the divalent alcohol having 6 or less carbon atoms is a transparent lotion from the viewpoint of improving moisturizing feeling and suppressing stickiness. It is preferable that it is 3 mass%-20 mass% with respect to the whole quantity of, and it is more preferable that it is 5 mass%-15 mass%.

When the transparent lotion of the present invention contains a divalent alcohol having 6 or less carbon atoms, the total content of water and the divalent alcohol having 6 or less carbon atoms is 55% by mass with respect to the total amount of the transparent lotion. % Or more, more preferably 65% by mass or more, and still more preferably 70% by mass or more.
Moreover, it is preferable that the sum total content of water and the C6 or less divalent alcohol in the transparent lotion of this invention is 95 mass% or less with respect to the whole amount of transparent lotion.

(Additive)
The transparent lotion of the present invention may contain various additives.
As the additive, various components that can be usually added to the skin lotion can be used depending on the purpose.

Specific additives include functional ingredients that exhibit useful cosmetic effects (such as anti-acne agents, whitening agents, keratin softeners, anti-inflammatory agents, blood circulation promoters), and moisturizing ingredients (water-soluble collagen, hydrolysis). Collagen, seaweed extract, camellia extract, sodium hyaluronate, etc.), chelating agents, pH adjusters, pH buffers, ultraviolet absorbers, fragrances, colorants, organic solvents, preservatives (phenoxyethanol, etc.), and the like. As the functional component, carotenoids other than astaxanthin such as β-carotene, zeaxanthin, lycopene, and lutein may be used.
The additive may be a water-soluble component or an oily component. When the additive is a water-soluble component, the additive is added in a form contained in the aqueous phase. When the additive is an oil-based component, it is added in a form solubilized in the aqueous phase, or emulsified particles (oil phase). It is preferably added in the form contained therein.
When the transparent lotion of the present invention contains an additive, the content of the additive needs to be an amount that can maintain the transparency of the lotion.

Specific examples of functional components such as whitening agents and anti-inflammatory agents used as additives and chelating agents include the following components.
Examples of whitening agents that can be used in the clear skin lotion of the present invention include tranexamic acid, dimers of tranexamic acid, amides of tranexamic acid, esters of tranexamic acid and hydroquinone, esters of tranexamic acid and gentisic acid, arbutin , Placenta extract, ellagic acid, kojic acid, lucinol and the like.
Among these, arbutin is particularly preferable as the whitening agent.

Anti-inflammatory agents that can be used in the clear skin lotion of the present invention include glycyrrhizic acid and its salts, glycyrrhetinic acid and its salts, aminocaproic acid, hydrocortisone, methyl salicylate, allantoin, azulene, licorice extract, chicone extract, aloe extract and the like. Can be mentioned.
Among these, as the anti-inflammatory agent, at least one component selected from the group consisting of dipotassium glycyrrhizinate, methyl salicylate, licorice extract, and aloe extract is preferable, and dipotassium glycyrrhizinate is more preferable.

Examples of the chelating agent that can be used in the transparent lotion of the present invention include citric acid, ethylenediaminetetraacetic acid (EDTA), etidronic acid, polyphosphoric acid, phytic acid, and the like. These chelating agents can also act as pH adjusting agents depending on the amount added.
Among these, citric acid is particularly preferable as the chelating agent.

<Physical properties of transparent lotion>
The pH of the transparent lotion of the present invention is preferably 5.4 to 6.0 from the viewpoint of astaxanthin stability.
Compounds selected from the group consisting of ascorbic acid, ascorbic acid derivatives, and salts thereof that contribute to the stability of astaxanthin when the pH of the transparent skin lotion of the present invention is in the range of 5.4 to 6.0, In addition, since ferulic acid can be stably contained in the transparent skin lotion, the stability of astaxanthin is further improved.
The method for measuring the pH of the transparent skin lotion of the present invention is not particularly limited. The pH of the transparent lotion of the present invention can be measured using, for example, HM-30R type (trade name) manufactured by Toa DKK Co., Ltd., and the value measured at 25 ° C. is adopted.

<Use of transparent lotion>
The use of the transparent lotion of the present invention is not particularly limited.
The transparent lotion of the present invention can be applied as cosmetics or quasi drugs.
The transparent lotion of the present invention can be suitably used for skin care, body care, scalp care and the like.

<Method for preparing transparent lotion>
The method for preparing the clear skin lotion of the present invention is not particularly limited. The transparent lotion of the present invention can be prepared according to a known method.

As an example of the method for preparing the transparent skin lotion of the present invention, a method for preparing when the transparent skin lotion of the present invention contains astaxanthin in the form of an emulsion will be described.
First, an oil-in-water emulsion (astaxanthin emulsion) in which emulsion particles (oil phase) containing astaxanthin are dispersed in an aqueous phase is prepared.
Astaxanthin emulsion obtained, glycerin, polyethylene glycol, at least one compound selected from the group consisting of ascorbic acid, ascorbic acid derivatives, and salts thereof, ferulic acid, water, and as required , And other ingredients.
A transparent lotion can be prepared by the above method.

-Preparation method of astaxanthin emulsion-
The astaxanthin emulsion can be prepared by a production method including mixing an oil phase composition containing astaxanthin and an aqueous phase composition and emulsifying by an ordinary method.
The oil phase composition preferably contains an oil component other than astaxanthin and lecithin together with astaxanthin.
On the other hand, the water phase composition preferably contains water, a water-soluble emulsifier, and a polyhydric alcohol.

An example of a preferred method for preparing an astaxanthin emulsion will be described.
First, water, a polyhydric alcohol, and a water-soluble emulsifier are mixed and dissolved to obtain an aqueous phase composition. Astaxanthin, an oil component other than astaxanthin, and lecithin are mixed and dissolved to obtain an oil phase composition.
Under stirring, the aqueous phase composition and the oil phase composition are mixed and emulsified and dispersed.
Astaxanthin emulsion can be prepared by the above method.

  The emulsification dispersion may be performed by a one-step emulsification operation, but it is preferable to perform the emulsification operation of two or more steps from the viewpoint of obtaining uniform and fine dispersed particles. For example, after emulsification using a normal emulsifier using a shearing action such as a stirrer, impeller agitation, homomixer, continuous flow type shearing device, etc. It is preferable to perform the high-pressure emulsification treatment used. By using a high-pressure emulsifying device, the emulsified particles can be made more uniform in particle size. For the purpose of further uniforming the particle size, emulsification and dispersion may be performed a plurality of times.

Examples of the chamber type high-pressure homogenizer include a microfluidizer (Microfluidics), a nanomizer (Yoshida Kikai Kogyo Co., Ltd.), an optimizer (Sugino Machine Co., Ltd.), and the like.
The homogeneous valve type high-pressure homogenizer includes Gorin type homogenizer (APV), Lanier type homogenizer (Ranie), high-pressure homogenizer (Niro Soabi), homogenizer (Sanwa Machinery Co., Ltd.), and high-pressure homogenizer (Izumi Food Machinery ( Co.), ultra-high pressure homogenizer (Ika).

The pressure of the high-pressure homogenizer is preferably 50 MPa or more, more preferably 50 MPa or more and 250 MPa or less, and still more preferably 100 MPa or more and 250 MPa or less.
From the viewpoint of maintaining the particle size of the emulsified particles, the emulsified and dispersed emulsion is preferably cooled through some cooler within 30 seconds, preferably within 3 seconds immediately after passing through the chamber.

  EXAMPLES Hereinafter, the present invention will be described more specifically with reference to examples. However, the present invention is not limited to the following examples unless it exceeds the gist thereof.

[Preparation of astaxanthin emulsion]
The following components were heated at 70 ° C. for 1 hour and dissolved to obtain an aqueous phase composition A.
-Composition of aqueous phase composition A-
・ Sucrose stearate (HLB = 16) 33.0 g
・ Decaglyceryl monooleate (HLB = 12) 67.0 g
・ Glycerin 450.0g
・ Pure water 300.0g

The following components were heated at 70 ° C. for 1 hour and dissolved to obtain an oil phase composition A.
-Composition of oil phase composition A-
・ Astaxanthin-containing oil 15.0g
(Krill extract, trade name: Astax-ST, Marine Daio Co., Ltd., containing 5% by mass of astaxanthin)
・ Mixed tocopherol 32.0g
(RIKEN E Oil 800, Riken Vitamin Co., Ltd.)
・ Medium chain fatty acid triglyceride 93.0 g
(Coconard (registered trademark) MT, tri (caprylic acid / capric acid) glyceryl, Kao Corporation)
・ Lecithin 10.0g
(Resion (registered trademark) P, derived from soybean, Riken Vitamin Co., Ltd.)

The obtained aqueous phase composition A was stirred at 10,000 rpm (round per minute) using an ultrasonic homogenizer (model: HP93, SMT Co., Ltd.) while maintaining the temperature at 70 ° C., and the stirred aqueous phase composition A Oil phase composition A was added to obtain a crude emulsion.
Next, the obtained crude emulsion was cooled to about 40 ° C., and high pressure emulsification was performed at a pressure of 200 MPa using an ultrahigh pressure emulsifier (model name: Ultimateizer HJP-25005, Sugino Machine Co., Ltd.). Thereafter, the obtained high-pressure emulsion was filtered using a microfilter having an average pore diameter of 1 μm to obtain an astaxanthin emulsion (astaxanthin content: 0.3% by mass).

  The obtained astaxanthin emulsion is diluted with ultrapure water so as to have a concentration of 1% by mass, and the particle size of the emulsified particles is determined using a particle size analyzer (model: FPAR-1000, Otsuka Electronics Co., Ltd.). When measured, it was 58 nm (median diameter (d)).

[Preparation of transparent lotion: Examples 1 to 8, Comparative Examples 1 to 26]
Transparent lotions were prepared by mixing and dissolving the components described in Tables 1 to 6 below. Of the components listed in Tables 1 to 6, those solid at room temperature were heated to about 60 ° C. and dissolved, and then mixed with other components.

Details of main components described in Tables 1 to 6 are as follows.
・ Glycerin (Concentrated glycerin for cosmetics, Kao Corporation)
Polyethylene glycol 1540 (standard component name, product name: PEG # 1540, average molecular weight: 1540, NOF Corporation)
-Polyethylene glycol 1000 (standard component name, product name: Toho polyethylene glycol 1000, average molecular weight: 1000, Toho Chemical Industry Co., Ltd.)
Polyethylene glycol 4000 (standard component name, product name: PEG # 4000, average molecular weight: 3100, NOF Corporation)
Polyethylene glycol 6000 (standard component name, product name: PEG # 6000, average molecular weight: 8800, NOF Corporation)
Ascorbic acid phosphate magnesium (NIKKOL (registered trademark) VC-PMG, Nikko Chemicals Co., Ltd.)
・ Ferula acid (Tsukino Food Industry Co., Ltd.)
Methyl Gluces-20 (Macbiobride (registered trademark) MG-20E, NOF Corporation)
PEG-60 hydrogenated castor oil (NIKKOL (registered trademark) HCO-60, Nikko Chemicals, HLB value: 14)
・ Water-soluble collagen (collagen P (PF), Nitta Gelatin Co., Ltd.)

In Tables 1 to 6, “ascorbic acid phosphate magnesium” is abbreviated as “APM”.
"-" Described in the column of composition in Tables 1 to 6 means that the corresponding component is not included.
Example 1 described in Table 1, Table 2, Table 3, and Table 6 is redundantly described for convenience of comparison, and all are the same. The same applies to Comparative Example 11 described in Tables 4 and 5 and Comparative Example 3 described in Tables 1 and 5.

[Evaluation]
1. Stability of astaxanthin Each transparent lotion obtained above was stored in the dark at 60 ° C. for 2 weeks, and the residual ratio (%) of astaxanthin after storage when the amount of astaxanthin before storage was taken as 100 was obtained. It was.
The amount of astaxanthin in the transparent lotion was analyzed using high performance liquid chromatography (HPLC) manufactured by Shimadzu Corporation and quantified by an absolute calibration curve method.
The analysis conditions are as follows.

-Analysis conditions-
Column: Capsule pack C8 (inner diameter: 4.6 mm × length: 150 mm, Shiseido Co., Ltd.)
Mobile phase: Liquid A) Methanol: Water = 75: 25, Liquid B) Methanol = 100
Gradient cycle: A liquid + B liquid = 100%, composition of B liquid is shown.
B liquid = 20% → 100% (0 minutes → 15 minutes)
Liquid B = 100% → 100% (15 minutes → 20 minutes)
Liquid B = 100% → 20% (20 minutes → 21 minutes)
Liquid B = 20% → 20% (21 minutes → 30 minutes)
Flow rate: 1 mL / min Column temperature: 40 ° C
Injection volume: 1 μL
Detection wavelength: 470 nm

Based on the obtained residual rate, the stability of astaxanthin was evaluated according to the following evaluation criteria. The results are shown in Tables 1-6.
“A” in the following evaluation criteria is a practically acceptable level.

-Evaluation criteria-
A: The residual rate of astaxanthin after storage is 90% or more.
B: The residual rate of astaxanthin after storage is 80% or more and less than 90%.
C: The residual ratio of astaxanthin after storage is less than 80%.

2. Feeling of use (1) Moisturizing feeling Each transparent skin lotion 50 μl obtained above was applied to the inside of the upper arm by 10 professional panelists for cosmetic evaluation, and after 5 minutes, the degree of moisturizing feeling was measured. I was judged. The panelists scored “1” when they felt that the moisturizing feeling was insufficient, and “2” when they felt that the moisturizing feeling was slightly insufficient. In this case, it was scored as “3”, when it was felt that the moisturizing feeling was slightly high, it was scored as “4”, and when it was felt that the moisturizing feeling was high, it was scored as “5”.
Average the scoring values of 10 professional panelists, round down the second decimal place, and based on the value obtained to the first decimal place (average value of scoring values) evaluated. The results are shown in Tables 1-6. In Tables 1 to 6, the average value of the scoring values is also shown.
“AA” and “A” in the following evaluation criteria are practically acceptable levels.

-Evaluation criteria-
AA: The average value of scoring values is 4.0 or more.
A: The average value of scoring values is 3.0 or more and less than 4.0.
B: The average value of scoring values is 2.5 or more and less than 3.0.
C: The average value of scoring values is less than 2.5.

  The skin moisture content inside the upper arm before and after the application of transparent skin lotion was measured using a Corneometer (trade name, Integral) for one paneler selected from the 10 panelists. In the application of the transparent skin lotion of Example 1 whose average value was “3.3”, the skin moisture content change was 20, and the average value of the scoring value was “1.1”. In the application of the transparent skin lotion, the skin water content change was 12.

(2) Feeling of stickiness when drying 50 μl of each of the transparent lotions obtained above was applied to the inside of the upper arm by 10 specialist panelists for cosmetic evaluation, and the degree of stickiness when drying was judged. . And if the panelist feels that it is not sticky when dry, it will be scored “1”, if it feels less sticky when dry, it will be scored “2”, and if it feels sticky when dry Was scored as “3”, and when it felt sticky when dry, it was scored as “4”.
Based on the value obtained by averaging the scoring values of 10 professional panelists, rounding off the second decimal place, and obtaining the first decimal place (average value of scoring values) according to the following evaluation criteria, The stickiness was evaluated. The results are shown in Tables 1-6. In Tables 1 to 6, the average value of the scoring values is also shown.
“AA” and “A” in the following evaluation criteria are practically acceptable levels.

-Evaluation criteria-
AA: The average value of scoring values is less than 2.0.
A: The average value of scoring values is 2.0 or more and less than 2.3.
B: The average value of the scoring values is 2.3 or more and less than 2.6.
C: The average value of scoring values is 2.6 or more.

3. Tackiness The stickiness (tackiness) when the transparent lotion dries on the skin was confirmed by measuring the normal stress of the skin to which the transparent lotion was applied.
Applying 10 μl of the transparent lotion of Example 1, Comparative Example 3, Comparative Example 5 and Comparative Example 6 obtained above to the inner side of the upper arm of one professional panel for cosmetic evaluation, It was measured with a static friction measuring machine (Tribomaster, Type: TL-201Ts, Trinity Lab Co., Ltd.).
The drive unit of the static friction measuring machine is slid in the vertical direction, the contact cycle speed between the contact and the coating part is set to 4 sec / cycle (cycle), and the vertical stress (tack force) when the contact is pulled up is set. It was measured.
The vertical stress was measured for 300 seconds after the start of measurement, and the maximum value of the vertical stress in one cycle was extracted. FIG. 1 shows a plot of the values obtained by averaging the maximum values of the extracted normal stress between 240 seconds and 300 seconds from the start of measurement.
If the average value of normal stress in 240 seconds to 300 seconds from the start of measurement is 20 gf (196.133 mN, 1 gf = 9.80665 mN) or less, it can be judged that the stickiness does not stick during drying or the sticky feeling during drying is small. .
In FIG. 1, the normal stress is expressed in “gf” units.

4). Transparency The absorbance at a wavelength of 625 nm of each of the transparent lotions obtained above was measured as follows.
2 ml of the transparent cosmetic material was placed in a cell having an optical path length of 5 mm, and the absorbance at 625 nm was measured with a spectrophotometer U-3310 manufactured by Hitachi, Ltd. using the cell having an optical path length of 5 mm. The measurement was performed under a temperature condition of 25 ° C. The results are shown in Tables 1-6.
In addition, as above-mentioned, in this invention, the lotion whose absorbance in wavelength 625nm is 0.3 or less is called transparent lotion, and it shows that it is a transparent lotion with high transparency, so that the numerical value of absorbance is small.

5). Scent The transparent lotion of Example 1 and the transparent lotion of Comparative Example 9 obtained above were stored in the dark at 40 ° C. for 1 month. About the transparent skin lotion after storage, one panelist was asked to confirm the presence or absence of a smell. In addition, the transparent lotion before storage does not feel a scent due to the effect of the fragrance.
As a result, the clear lotion of Example 1 did not feel the smell of live smell, but the clear lotion of Comparative Example 9 containing no ferulic acid felt the smell of fresh smell.
From the above results, it was found that in the case of a transparent lotion containing krill-derived astaxanthin, the use of krill-derived astaxanthin and ferulic acid together suppresses the generation of a raw odor.

As can be seen from Tables 1 and 2, the transparent skin lotions of Examples 1 to 8 are excellent in the stability of astaxanthin, and when applied to the skin, a good moisturizing feeling is obtained, and when dried. It was a transparent lotion with reduced stickiness.
On the other hand, as can be seen from Table 1 and Tables 3 to 6, the transparent skin lotions of Comparative Examples 1 to 26 are at least one of the stability of astaxanthin, the moisturizing feeling, and the suppression of stickiness when dried. It was inferior compared with Example 1- Example 8 by the above point.
As shown in FIG. 1, the transparent lotion of Example 1 shows that the sticky feeling at the time of drying is suppressed also from the tackiness result. In addition, it turns out that the result of Example 1, the comparative example 3, the comparative example 5, and the comparative example 6 shown in FIG. 1 correlates with the evaluation result (sensory evaluation by a professional monitor) of the stickiness feeling at the time of drying.

FIG. 2 shows the correlation between the moisturizing feeling and the sticky feeling during drying when the transparent lotions of the examples and comparative examples are applied to the skin.
From the results of Comparative Examples 11 to 17 shown in Table 4 and FIG. 2, in the transparent lotion not containing glycerin, when polyethylene glycol is used instead of glycerin, a moisturizing feeling can be obtained, but the moisturizing feeling is improved. It can be seen that the stickiness during drying increases.
In addition, from the results of Comparative Example 3, Comparative Example 11, and Comparative Examples 18 to 22 shown in Table 5 and FIG. 2, in transparent lotion that does not contain polyethylene glycol, when glycerin is used instead of polyethylene glycol, moisture retention A feeling can be obtained, but it can be seen that the sticky feeling at the time of drying increases as the moisturizing feeling improves.
From these results, it is considered that it is difficult to achieve both a good moisturizing feeling and a feeling of stickiness during drying with a transparent lotion containing only one of glycerin and polyethylene glycol.

  However, from the results of Comparative Examples 1 to 7 shown in Table 1 and Comparative Examples 23 to 26 shown in Table 6, even though the transparent lotion contains both glycerin and polyethylene glycol, When the content of at least one is less than 2.3% by mass or more than 3.7% by mass with respect to the total amount of the transparent lotion, a good moisturizing feeling cannot be obtained, or It can be seen that the sticky feeling during drying is not suppressed.

  That is, it can be seen from the results of the graph shown in FIG. 2 that by using a specific amount of glycerin and a specific amount of polyethylene glycol in combination, it is possible to improve the moisturizing feeling while suppressing an increase in stickiness during drying. .

As can be seen from Table 3, the clear lotion of Comparative Example 8 not containing ferulic acid and the clear lotion of Comparative Example 9 not containing magnesium ascorbate phosphate were both ferulic acid and magnesium ascorbate phosphate. Astaxanthin was inferior in stability to the transparent lotion of Example 1 containing
The transparent lotion of Comparative Example 10 containing both ferulic acid and magnesium ascorbate phosphate but containing 3% by mass of magnesium ascorbate phosphate with respect to the total amount of the transparent lotion is an example. Like the transparent lotion of No. 1, the sticky feeling at the time of drying could not be suppressed.

6). Verification of fatty acid oxidation inhibitory effect by ferulic acid By the method shown below, the oxidation inhibitory effect of fatty acid by ferulic acid was verified. In the verification, arachidonic acid was used as the fatty acid, and the concentration of acrolein (derived from lipid peroxide generated by ultraviolet irradiation of arachidonic acid) was used as an index of the fatty acid oxidation inhibitory effect.
(1) Arachidonic acid (Tokyo Chemical Industry Co., Ltd.) was added to ethanol and mixed to prepare an ethanol solution containing 50 mM arachidonic acid. Further, by adding arachidonic acid and ferulic acid (Tsukino Food Industry Co., Ltd.) to ethanol and mixing them, an ethanol solution containing 50 mM arachidonic acid and 50 mM ferulic acid, 50 mM arachidonic acid and 100 mM ferulic acid are mixed. An ethanol solution containing an acid was prepared.
(2) Four wells each in a well of a 12-well plate (Costar (registered trademark) cell culture plates 3513, Corning), an ethanol solution containing 50 mM arachidonic acid prepared above, 50 mM arachidonic acid and 50 mM ferula An ethanol solution containing acid and an ethanol solution containing 50 mM arachidonic acid and 100 mM ferulic acid are collected, and then the wells are sealed using a microplate seal (trade name: Titerstick HE, Kajix Co., Ltd.). A verification sample was prepared. In addition, the microplate seal | sticker used what has ultraviolet (UV) permeability | transmittance for the below-mentioned pseudo sunlight irradiation.
(3) A total of three verification samples were produced according to the procedures of (1) and (2) above.
(4) Next, using a solar simulator (trade name: Q-SUN Xe-1-BC Xenon Test Chamber, Q-LABab Corporation) for each verification sample, simulated sunlight is emitted for a certain period of time. Specifically, the irradiation was performed so that the total irradiation time was 0.5 hr, 1 hr, and 3 hr, respectively. The concentration of acrolein in each ethanol solution before irradiation (total irradiation time: 0 hr) and after irradiation (total irradiation time: 0.5 hr, 1 hr, 3 hr) was measured using high performance liquid chromatography (HPLC ) And quantified by the absolute calibration curve method. The results are shown in FIG.
The analysis conditions are as follows.

-Analysis conditions-
Column: Capsule pack C18 (inner diameter: 4.6 mm x length: 250 mm, Shiseido Co., Ltd.)
Mobile phase: Liquid A) 0.1% by mass phosphoric acid aqueous solution
Liquid B) Acetonitrile containing 0.1% by mass phosphoric acid Gradient cycle: liquid A + liquid B = 100%, and the composition of liquid B is shown.
B liquid = 0% → 20% (0 minutes → 10 minutes)
Liquid B = 20% → 80% (15 minutes → 23 minutes)
B liquid = 80% → 100% (23 minutes → 40 minutes)
Liquid B = 100% → 0% (41 minutes → 65 minutes)
Flow rate: 1 mL / min Column temperature: 40 ° C
Injection volume: 20 μL
Detection wavelength: 210 nm
Detector: UV-Vis (ultraviolet visible spectroscopy) detector

In FIG. 3, arachidonic acid is expressed as “AA” and ferulic acid is expressed as “Fer”.
In FIG. 3, the total irradiation time of the simulated sunlight is simply expressed as “light irradiation time”.

  As shown in FIG. 3, according to ferulic acid, it became clear that the production | generation of acrolein from arachidonic acid by irradiation of the sunlight containing an ultraviolet-ray can be suppressed.

Claims (2)

A transparent lotion containing (i) to (vi), wherein the ratio of the content of glycerin to the content of polyethylene glycol in the transparent cosmetic is 0.7 to 1.2 on a mass basis, (Iv) at least one compound selected from the group consisting of ascorbic acid, ascorbic acid derivatives, and salts thereof is ascorbic acid, magnesium ascorbate phosphate, sodium ascorbate phosphate, magnesium ascorbate sulfate A transparent lotion having a pH of 5.4 to 6.0, which is at least one compound selected from the group consisting of sodium sulfate ascorbate and sodium ascorbyl palmitate .
(I) Glycerin having a content of 2.3% to 3.7% by mass with respect to the total amount of the transparent skin lotion (ii) A content of 2.3% to 3.7% by mass with respect to the total amount of the transparent skin toner. Polyethylene glycol (iii) Astaxanthin (iv) The content of the clear skin lotion is 0.1% by mass to 3% by mass, and at least one selected from the group consisting of ascorbic acid, ascorbic acid derivatives, and salts thereof Seed compound (v) Ferulic acid (vi) Water having a content of 50% by mass or more based on the total amount of the transparent skin lotion   The transparent lotion according to claim 1, wherein the astaxanthin is krill-derived astaxanthin.