JP6474227B2 - Composition for toiletry products containing plant extract - Google Patents

Description

  The present invention relates to a composition for toiletry products containing a plant extract.

  Toiletries are daily necessities aimed at cleaning the body and adjusting personal tastes, and are also called personal care products. Toiletries include soap, lotion, bath preparation (bath). A toiletry product is a product with strong palatability among daily necessities, and there is an aspect in which a consumer selects a product according to a preference such as aroma and color. There are also toiletry products with added value using plant-derived raw materials and functional products that have effects such as whitening or moisturizing. An example of such a functional product is a bath agent having an anti-inflammatory effect (Patent Document 1). Patent document 1 describes the bath agent containing a garlic extract derivative.

In general, a bath agent has an effect of enhancing a warm bath effect (warming the body and / or promoting blood circulation) and a cleansing effect (cleaning the skin) obtained by bathing, but depending on the warm bath effect or bath agent obtained by bathing. The enhanced warm bath effect may exacerbate itching in users who suffer from pruritus, such as patients with atopic dermatitis.
It is described that the bath preparation described in Patent Document 1 has a pruritus-reducing action for certain atopic dermatitis patients.

JP-A-5-009110

The pruritus mitigating effect of conventional bath preparations may not be satisfactory. Moreover, in the bath preparation using a plant-derived raw material, it may be difficult to increase the content of the plant-derived raw material having an effect of reducing pruritus from the viewpoint of fragrance and the like. Functional products having an effect of reducing pruritus are desired not only for bath agents but also for all toiletry products. Accordingly, one object of the present invention is to provide a composition for toiletry products containing a plant-derived raw material having a good pruritus-reducing effect.
In addition, there have been cases where the conventional moisturizing effect, the protective effect on the skin barrier function, and the improving effect of toiletries such as bath preparations cannot be satisfied. Accordingly, one object of the present invention is to provide a composition for toiletry products having a good moisturizing effect, a protective effect on the skin barrier function, an improving effect and the like.

  As a result of intensive studies on combinations of various plant extracts to solve the above problems, the present inventors have found that a composition containing a citrus peel extract, a thyme extract and a rooibos tea extract has a good pruritus-reducing action and a good It has been found that it exhibits a moisturizing action, a protective action of the skin barrier function, an improving action, etc., and has completed the present invention.

That is, the present invention provides the following composition or toiletry product.
[1] A composition for toiletry products, comprising a citrus peel extract, a thyme extract and a rooibos tea extract.
[2] The composition according to [1], wherein the citrus peel extract is a chimpi extract.
[3] The composition according to [1] or [2], wherein the toiletry product is selected from the group consisting of soap, lotion, and bath preparation.
[4] The composition according to [1] or [2], wherein the toiletry product is a bath preparation.
[5] The composition contains 0.01 to 20% by mass of citrus peel extract, 0.01 to 10% by mass of thyme extract, and 0.01 to 10% by mass of rooibos tea extract, [1] to [4] The composition according to any one of [4].
[6] Containing 0.1 to 10% by mass of citrus peel extract, 0.05 to 3% by mass of thyme extract, and 0.01 to 1% by mass of rooibos tea extract per amount of the composition substance, according to [5] The composition as described.
[7] A toiletry product comprising the composition according to any one of [1] to [6].

The composition according to the present invention has a good pruritus-reducing action. The composition according to the present invention may have a good rash improving action. In addition, the composition according to the present invention can have a good moisturizing action, a good protective action for skin barrier function, and an improving action.
Furthermore, the composition according to the present invention can exert a sufficient effect on a subject (particularly a human) for which the conventional composition cannot sufficiently exhibit the above effect.

The measurement result of residual chlorine concentration in tap water is shown. About the test drug of Test example 4, the result of having calculated the measured value after application of the test drug with respect to the measured value before the rough skin treatment of the transepidermal water loss (hereinafter referred to as “TEWL”) is shown.

  In the present specification, “citrus fruits” means fruit trees of the genus Citrus or Citrus. The fruit tree of the mandarin genus includes, but is not limited to, fruit trees of oranges, citrus citrus fruits, and mandarin oranges. Examples of orange fruit trees include, but are not limited to, Bitter Orange. Examples of perfume citrus fruit trees include, but are not limited to, Kabos (Citrus sphaerocarpa), Sudachi (Citrus sudachi), Yuzu (Citrus junos), and Lemon (Citrus limon). Citrus fruit trees include, but are not limited to, Citrus unshiu, Citrus kinokuni, and Ponkan (Citrus tangerina). Examples of kumquat fruit trees include, but are not limited to, Nympho kumquat (Ningbo Kumquat Fortunella crassifolia) and Mulkin kumquat (Marukan Kumquat Furtunella Japonica).

  In the present specification, “time” means Thusus vulgaris Linne '(Labiatae) belonging to the genus Lamiaceae.

  In the present specification, “Rooibos tea” means a dried leaf of Aspartus linearis.

In the present specification, the “citrus peel extract” means an extract obtained from the peel of a citrus fruit tree. The citrus peel extract may be a commercially available citrus peel extract or a peel extract extracted from citrus peel according to a conventional method. The peel of the fruit tree used for extraction may be the peel of a fruit tree before ripeness or the peel of a fully ripe fruit tree. For example, it may be an unripe Unshu mandarin peel (also referred to as “seed”) or an unripe Unshu mandarin peel (also referred to as “Chimpi”). In the extraction of the peel extract, the peel of the fruit tree may be used as it is, or the peel of the dried fruit tree may be used.
In the present specification, the “citrus peel extract” may be one or a mixture of two or more peel extracts of the fruit tree of the citrus fruit tree and the fruit tree of the kumquat fruit tree. A particularly preferred citrus peel extract is chimpi extract.

  In this specification, “time extract” means an extract obtained from thyme. The thyme extract may be a commercially available extract or may be an extract extracted from thyme leaves according to a conventional method. In extraction of thyme extract, thyme leaves may be used as they are, or dried thyme leaves may be used.

  As used herein, “Rooibos tea extract” means an extract obtained from leaves of rooibos. The rooibos tea extract may be a commercially available extract or may be an extract extracted from rooibos leaves according to a conventional method. In the extraction of rooibos tea extract, rooibos leaves may be used as they are, or dried rooibos leaves may be used.

A method for producing a plant extract such as citrus peel extract, thyme extract and rooibos tea extract may be a method of immersing in an extraction solvent, a steam distillation method, or a method using a supercritical fluid or a subcritical fluid. From the viewpoint of extraction efficiency, stirring may be performed, or homogenization may be performed in an extraction solvent. Furthermore, although it does not limit in the manufacturing process of a plant extract, you may combine suitably the separation method and purification methods by centrifugation, ultrafiltration, column chromatography, etc.
The plant extract obtained by the above extraction is a crudely purified product as long as it conforms to a standard that is allowed to be blended into a pharmaceutical, quasi-drug or cosmetic by the extraction method and exhibits the effects of the present invention. It may be.

  There are no particular limitations on the extraction solvent, and water, hot water, hot water; lower monohydric alcohols such as methanol, ethanol, propanol, and butanol; many solvents such as propylene glycol, dipropylene glycol, butylene glycol, glycerin, and 1,3-butanediol Monohydric alcohols; esters such as methyl acetate and ethyl acetate; ketones such as acetone and methyl ethyl ketone; halogenated hydrocarbons such as chloroform and carbon tetrachloride; ethers such as diethyl ether and tetrahydrofuran; hexane, heptane and cyclohexane The organic solvents generally used for extraction, such as hydrocarbons, may be used, and a single solvent selected from these or a mixture of two or more may be used.

  The plant extract is not particularly limited, but may be a liquid, a paste concentrated by vacuum concentration or the like, or a dried or lyophilized powder, or a liquid obtained by re-dissolving the powder in a solvent. In the case of a liquid, the solvent used for extraction or the solvent for redissolving the plant extract powder is preferably a solvent with low skin irritation such as water, ethanol, 1,3-butylene glycol, or a mixed solvent of these with water.

  What is necessary is just to use suitably the plant extract extract mix | blended with the composition of this invention what is marketed as an item as described in a quasi-drug raw material specification, a Japanese pharmacopoeia, a pharmaceutical additive specification, or a general cosmetic raw material.

  The composition of the present invention can be used as a toiletry product. Therefore, this invention provides the composition for toiletry products containing a citrus peel extract, a thyme extract, and a rooibos tea extract.

  As used herein, “toiletries” refers to daily products applied to the skin, including but not limited to bath preparations, soaps such as solid soaps, liquid soaps, cream soaps (mousse soaps), and the like. Skin care products such as lotions, body rinses and emulsions. In one embodiment of the present invention, soaps, lotions and bathing agents are preferred, and bathing agents are more preferred.

The composition for toiletry products of the present invention may be prepared by blending citrus peel extract, thyme extract and rooibos tea extract into known formulations for various toiletry products, or by replacing a part of the known formulation with these extracts. Good.
The composition for toiletry products of the present invention is typically 1: 0.025 to 2.5: 0.01 to 1.0 (citrus fruits) with citrus peel extract, thyme extract and rooibos tea extract as a mixing ratio (mass ratio). (Fruit peel extract: time extract: rooibos tea extract), preferably 1: 0.1 to 1.0: 0.05 to 0.5. What is necessary is just to determine suitably the compounding quantity to the toiletry product of a citrus peel extract, a thyme extract, and a rooibos tea extract according to the characteristic of the product.
In addition, in this specification, the quantity of a plant extract shall show the quantity of solid content, unless there is particular notice.

  In the present invention, the total amount of the composition is 100% by mass, usually 0.01-20% by mass of citrus peel extract, 0.01-10% by mass of thyme extract and 0.01-10% by mass of rooibos tea extract. A composition for toiletry products is provided.

  The composition of the present invention can be used as a bath agent. In this case, the total amount of the composition in the bath preparation is 100% by mass, usually 0.1 to 10% by mass of the citrus peel extract, 0.05 to 3% by mass of the thyme extract and 0. 0% of the rooibos tea extract. 01 to 1% by mass, preferably 0.5 to 5% by mass of citrus peel extract, 0.2 to 1.5% by mass of thyme extract and 0.05 to 0.5% by mass of rooibos tea extract It is.

  When the bath preparation in the present invention is dissolved in bath water, the total amount of citrus peel extract, thyme extract and rooibos tea extract per 200 L of hot water is 0.3 to 30 g, preferably 0.54 to 13.5 g. Preferably, it can be adjusted to 1.08 to 6.75 g.

The bath agent in the present invention can be prepared by blending known optional components blended in conventional bath agents as components other than the citrus peel extract, thyme extract and rooibos tea extract according to a conventional method. Such optional ingredients include, but are not limited to, citrus peel extracts, plant extracts other than thyme extract and rooibos tea extract, carbonates, organic acids, inorganic pigments, humectants, preservatives, perfumes, inorganic salts, Examples include oil components, lubricants, water-soluble polymers, colorants, and the like. These components can be blended singly or in combination of two or more depending on the dosage form or application of the bath agent.
Although the specific example of the said component is given to the following, it is not limited to these.

  Plant extract extracts other than citrus peel extract, thyme extract and rooibos tea extract include garlic extract and chamomile extract.

  Examples of the carbonate include sodium carbonate, sodium bicarbonate, magnesium carbonate, potassium carbonate, potassium bicarbonate, sodium sesquicarbonate, and ammonium carbonate.

  Examples of the organic acid include succinic acid, fumaric acid, malic acid, adipic acid, tartaric acid, citric acid, malonic acid, and maleic acid.

  Examples of the inorganic pigment include titanium oxide, calcium carbonate, magnesium carbonate, zinc oxide, talc, calcium silicate, anhydrous silicic acid, kaolin, bentonite, and mica titanium.

  As the humectant, saccharides such as sorbitol, xylitol, maltitol, dextrin, glucose, maltose, lactose, saccharose, xylose, fructose, mannitol, lactitol; ethylene glycol, propylene glycol, 3-methyl-1,3-butanediol, Examples include polyhydric alcohols such as glycerin and 1,3-butylene glycol (BG); amino acids such as sodium pyrrolidonecarboxylate and sodium glutamate; and urea.

  Examples of the preservative include paraoxybenzoic acid ester (for example, methylparaben), benzoic acid, benzoate, and phenoxyethanol.

  Examples of the fragrances include natural fragrances such as lavender oil, jasmine oil, and lemon oil, and synthetic fragrances such as geraniol, citronellol, and phenethyl alcohol.

  Examples of inorganic salts include sodium sulfate, magnesium sulfate, sodium chloride, potassium chloride, sodium thiosulfate, magnesium oxide, aluminum sulfate, alum, and metasilicate.

  Oil components include soybean oil, nutka oil, jojoba oil, avocado oil, almond oil, olive oil, cacao butter, sesame oil, persic oil, castor oil, coconut oil, mink oil, beef tallow, pork fat, etc. Hardened oil obtained by hydrogenation of natural fats and oils, synthetic glycerides such as myristic acid glyceride and 2-ethylhexanoic acid glyceride, fats such as diglyceride; waxes such as carnauba wax, whale wax, beeswax, lanolin; liquid paraffin, petrolatum Hydrocarbons such as paraffin, microcrystalline wax, ceresin, squalane, pristane; higher grades such as lauric acid, myristic acid, palmitic acid, stearic acid, behenic acid, oleic acid, linoleic acid, linolenic acid, lanolinic acid, isostearic acid Fatty acids: lauryl alcohol, cetyl alcohol , Stearyl alcohol, oleyl alcohol, cholesterol, 2-hexyldecanol and other higher alcohols; cetyl octanoate, myristyl lactate, cetyl lactate, isopropyl myristate, isopropyl palmitate, isopropyl adipate, butyl stearate, decyl oleate, isostearic acid Esters such as cholesterol; essential oils; silicone oils.

  Examples of the lubricant include kaolin, polyethylene glycol, talc, magnesium stearate, calcium stearate, silicone oil, oily component, and starch.

  Examples of water-soluble polymers include natural water such as glue, gelatin, collagen protein, casein, sodium alginate, carrageenan, farseleran, tamarind gum, pectin, gum arabic, guar gum, xanthan gum, tragacanth gum, locust bean gum, dextran, agar, starch, etc. Polymers: Semi-synthetic water-soluble polymers such as carboxymethylcellulose, methylcellulose, hydroxyethylcellulose, hydroxypropylcellulose, cellulose acetate phthalate, propylene glycol alginate, oxidized starch, esterified starch, etherified starch, and cationic starch; polyacrylic Examples thereof include synthetic water-soluble polymers such as sodium acid, polyethyleneimine, polyvinyl alcohol, polyethylene glycol, and polyvinylpyrrolidone.

Examples of the colorant include riboflavin (vitamin B ₂ ), carotene, and chlorophyll.

  What is necessary is just to select each component suitably according to prescription of the bath agent conventionally known. The bath preparation in the present invention can be produced by appropriately selecting and mixing the citrus peel extract, thyme extract and rooibos tea extract and the above-mentioned optional components. For example, there is a method for producing a bath agent in powder form by mixing citrus peel extract, thyme extract and rooibos tea extract in powder form with other powder ingredients, and then mixing with a small amount of oily component. Illustrated.

The composition of the present invention can be used as a skin care product (for example, lotion). In the case of lotion, it is prepared by blending known optional components blended in conventional lotions according to a conventional method as components other than citrus peel extract, thyme extract and rooibos tea extract. Known optional ingredients to be blended into the skin lotion include, but are not limited to, citrus peel extract, thyme extract and rooibos tea extract other than the plant extract, organic acid, humectant, preservative, Examples include a fragrance, the oily component (liquid oil, etc.), the lubricant, the water-soluble polymer, alcohols, and a surfactant (solubilizer). These optional components can be blended alone or in combination of two or more depending on the application or dosage form of the skin lotion.
Although the specific example of the said component is illustrated below, it is not limited to these.

  Examples of alcohols include ethanol, propanol, glycerin, propylene glycol, and 1,3-butylene glycol.

  As the surfactant (solubilizer), for example, polyoxyethylene fatty acid ether, polyoxyethylene fatty acid ester, polyoxyethylene alkyl ether, polyoxyethylene polyoxypropylene alkyl ether, polyoxyethylene alkylphenyl ether, polyoxyethylene Cholesteryl ether, polyoxyethylene phytosterol ether, polyoxyethylene polyoxypropylene phytosterol ether, polyoxyethylene hydrogenated castor oil, polyoxyethylene sorbitan fatty acid ester, polyoxyethylene sorbit fatty acid ester, polyoxyethylene fatty acid glycerin, polyglycerin fatty acid ester, Sucrose fatty acid ester, fatty acid soap, N-acyl glutamate, acyl taurate, acyl a Quiltaurine salts, higher alkyl sulfates, alkyl ether sulfates, N-acyl sarcosinates, higher fatty acid amide sulfonates, phosphate esters, sulfosuccinates, alkylbenzene sulfonates, polyoxyethylene methyl ether dimethicone and Examples include polyoxyethylene / methylpolysiloxane.

  Examples of the liquid oil include fats and oils, fatty acids, ester oils, hydrocarbon oils, higher alcohols, and silicone oils.

  Oils include linseed oil, camellia oil, macadamia nut oil, corn oil, olive oil, avocado oil, sasanqua oil, castor oil, safflower oil, kyounin oil, cinnamon oil, jojoba oil, grape oil, sunflower oil, almond oil, rapeseed Oil, sesame oil, wheat germ oil, rice germ oil, rice bran oil, cottonseed oil, soybean oil, peanut oil, teaseed oil and evening primrose oil.

  Examples of fatty acids include heptanoic acid, octanoic acid, nonanoic acid, decanoic acid, pentadecanoic acid, heptadecanoic acid, nonadecanoic acid, isostearic acid, oleic acid, linoleic acid, linolenic acid and arachidonic acid.

  The ester oils include pentaerythritol tetraoctanoate, cetyl octanoate, hexyl laurate, isopropyl myristate, octyldodecyl myristate, octyl palmitate, isopropyl istearate, octyl isopalmitate, isodecyl oleate and cetyl ethylhexanoate. Is mentioned.

  Hydrocarbon oils include liquid paraffin, squalane, squalene, paraffin, isoparaffin, octane, decane, dodecane, isododecane, hexadecane and isohexadecane.

  Higher alcohols include octyl alcohol, isostearyl alcohol and oleyl alcohol.

  Examples of the silicone oil include chain silicones such as dimethylpolysiloxane, methylphenylpolysiloxane, and methylhydrogenpolysiloxane, and cyclic silicones such as octamethylcyclotetrasiloxane, decamethylcyclopentasiloxane, and dodecamethylcyclohexasiloxane. .

The composition of the present invention can be used as a soap. In this case, soap is prepared by blending known optional components blended in conventional soap as components other than citrus peel extract, thyme extract and rooibos tea extract according to a conventional method. Known optional ingredients to be blended in the soap include, but are not limited to, the plant extract extract other than the citrus peel extract, thyme extract and rooibos tea extract, the moisturizer, the preservative, the fragrance, and the oil component. The lubricant, the water-soluble polymer, soap base, chelating agent, surfactant, higher alcohols, antioxidant, metal sequestering agent, anti-inflammatory agent and the like are exemplified. These optional components can be blended in one or more kinds depending on the use or dosage form of the soap.
Although the specific example of these components is illustrated below, it is not limited to this.

  For example, the soap base may be saponified with caustic soda, for example, animal oils such as beef tallow and sheep fat, vegetable oils such as coconut oil, palm oil, palm kernel oil, soybean oil, olive oil, and cottonseed oil. It can be obtained by neutralizing each or a mixture of fatty acids obtained by decomposing oil and fat with caustic soda, caustic potash, alkanolamine and the like.

  Soap base can be applied without particular limitation as long as it is a generally known solid soap, and it is mainly composed of acylated sodium glutamate as well as solid soaps mainly composed of fatty acid sodium soap and triethanolamine soap. It can also be applied to soap. Also, it can be applied to ordinary opaque solid soap and transparent solid soap.

  Examples of the chelating agent include EDTA, DTPA (diethylenetriaminetetraacetic acid), hydroxyethanediphosphonic acid, and the like.

  Surfactants include anionic surfactants such as sodium lauryl sulfate and alkylsulfosuccinates, cationic surfactants such as quaternary alkylamine salts, polyoxyethylene cetyl ether, polyethylene glycol monostearate, glyceryl monostearate, Polyoxyethylene sorbitan monolaurate, polyoxyethylene lauryl ether, polyoxyethylene polyoxypropylene glycol, fatty acid monoglyceride, polyoxyethylene hydrogenated castor oil, polyoxyethylene sorbitan fatty acid ester, polyoxyethylene stearyl ether, polyoxyethylene oleyl Ether, polyoxyethylene higher alcohol ether, polyoxyalkyl allyl ether, polyoxyethylene distyrenated Nyl ether, polyoxyethylene derivative, sorbitan monolaurate, sorbitan monooleate, sorbitan sesquioleate, sorbitan monolaurate, polyoxyethylene monolaurate, polyoxyethylene sorbitan laurate, polyoxyethylene sorbitan monostearate, Polyoxyethylene sorbitan monooleate, 1-polyoxyethylene sorbitan monolaurate, polyoxyethylene sorbitan monooleate, polyoxyethylene sorbitan tetraoleate, polyethylene glycol monolaurate, polyethylene glycol monooleate, polyoxythielen castor Nonionic surfactant such as oil, polyoxyethylene lanolin, alkylbetaine, glycine type, alkylaminobetaine, imidazo Emission type, L- arginine and amphoteric surfactants such as L- lysine-type, monostearate polyoxyethylene sorbitan, nonionic surfactants such as polyoxyethylene stearic acid amide.

  Examples of higher alcohols include cetanol, stearyl alcohol, capryl alcohol, lauryl alcohol, myristyl alcohol, cetyl alcohol, cholesterol, phytosterol, hexyl decanol, octyldodecanol and behenyl alcohol.

  Antioxidants include vitamin E and butylhydroxytoluene (BHT).

  Examples of metal sequestering agents include disodium edetate, trisodium edetate, tetrasodium edetate, sodium citrate, sodium polyphosphate, sodium metaphosphate and gluconic acid.

  Anti-inflammatory agents include β-glycyrrhetinic acid and tranexamic acid.

  The composition for toiletry products of the present invention has a good pruritus-reducing action and can improve dermatitis, for example, rash in patients with atopic dermatitis.

  In the present specification, “pruritus” or “itch” means a sensation of the skin mucosa different from pain. The cause of pruritus is said to be an increase in the amount of histamine, an increase in the number of mast cells, an abnormality in acetylcholine secretion, etc., and itching can occur with skin diseases such as dermatitis. Skin diseases with pruritus or itching include, but are not limited to, atopic dermatitis, senile pruritus (pruritus senilis), and cutaneous pruritus in dialysis patients. Itching or itching can be caused by excessive drying of the skin.

  As used herein, “skin rash” or “rash” refers to skin changes observed with the naked eye and includes, but is not limited to, rashes that appear with dermatitis such as atopic dermatitis.

  Moreover, the composition for toiletry products of this invention has a favorable moisturizing effect while reducing pruritus. It is presumed that the good moisturizing action that can be achieved by the toiletry product composition according to the present invention is brought about by the improvement of the water content in the stratum corneum. Increased moisture content in the stratum corneum results in improved skin barrier function and reduces itching or itching that can be caused by external stimuli.

  Furthermore, the bath preparation of the present invention is a causative substance of skin irritation and exhibits an action of removing free chlorine, which is supposed to reduce the barrier function of the skin.

  The present invention will be described in detail by the following examples, but the present invention is not limited to these examples.

ａ）チンピ（Citrus unshiu Markovich）の粉末１ｋｇに対して水１５Ｌを加え、撹拌抽出した。得られた抽出液をろ過し、そのろ液を減圧下にて濃縮した。濃縮液に、濃縮液の固形分に応じてデキストリンを加え、乾燥してチンピエキス散を得た。
ｂ）タイム（Thymus vulgaris Linne’(Labiatae)）の全草の粉末１ｋｇに水２０Ｌを加え、撹拌抽出した。得られた抽出液をろ過し、そのろ液を減圧下にて濃縮し、乾燥してタイムエキス末を得た。
ｃ）ルイボス（Aspalathus Linearis）の葉の粗末１ｋｇに水１０Ｌを加え、１時間加熱抽出した。得られた抽出液をろ過し、そのろ液を減圧下にて濃縮し、乾燥してルイボスティーエキス末を得た。 Examples 1-3 Manufacture of the composition for bath preparations containing a plant extract The component amount of Table 1 was measured, and each component was stirred and mixed and manufactured.

a) 15 L of water was added to 1 kg of powder of chimpi (Citrus unshiu Markovich), and the mixture was extracted with stirring. The obtained extract was filtered, and the filtrate was concentrated under reduced pressure. To the concentrate, dextrin was added according to the solid content of the concentrate and dried to obtain a chimpi extract powder.
b) 20 L of water was added to 1 kg of whole plant powder of thyme (Thymus vulgaris Linne '(Labiatae)) and extracted with stirring. The obtained extract was filtered, and the filtrate was concentrated under reduced pressure and dried to obtain a thyme extract powder.
c) 10 L of water was added to 1 kg of crude powder of rooibos (Aspalathus Linearis), and the mixture was extracted by heating for 1 hour. The obtained extract was filtered, and the filtrate was concentrated under reduced pressure and dried to obtain a rooibos tea extract powder.

Example 4 Manufacture of the composition for skin lotions containing a plant extract It manufactured by mix | blending ingredients other than the water of Table 2 with water. In Table 2, chimpi extract powder, thyme extract powder and rooibos tea extract powder are the same as in Table 1.

ａ）ＰＥＧ＃４０００Ｋ、ライオン株式会社
Example 5 Manufacture of the composition for soap containing a plant extract It manufactured by mix | blending and shape | molding components other than the soap base | substrate of Table 3 in soap base. In Table 3, Chimpi extract powder, thyme extract powder and rooibos tea extract powder are the same as in Table 1.

a) PEG # 4000K, Lion Corporation

Test Example 1 Reduction of itching and improvement of skin eruption It was tested for reduction of itching and improvement of skin rash in patients with atopic dermatitis. Thirty patients with atopic dermatitis were subjects. All subjects were over 13 years old.
Test hot water was prepared by dissolving 30 grams of the composition of Example 1 in about 200 liters of hot water (about 40 ° C.). The test period was 2 weeks. Subjects used internal and external medications as usual during the study period. The degree of stagnation was determined using the five-step criteria shown in Table 4 below.

The following criteria were used to reduce itching:
“Very effective”: The evaluation shown in the criteria of Table 4 is improved by 3 levels;
“Effective”: The evaluation shown in the criteria of Table 4 is improved by two levels;
“Slightly effective”: The evaluation shown in the criteria of Table 4 is improved by one level;
“Invalid”: No change or deterioration in the evaluation shown in the judgment criteria of Table 4.
Regarding the improvement of skin eruption, the condition of the skin before the test (skin rash) was compared with the condition of the skin after the test (skin eruption). Judgment was made.

  Regarding the reduction of itching compared to before use by using the composition of Example 1, 3 (10%) of 30 subjects were “very effective” and 11 (36.7%) were “ Eight (26.7%) were judged as “slightly valid” and eight (26.7%) were judged as “invalid”. Regarding the improvement of skin eruption by using the composition of Example 1 compared to before use, 26 (86.7%) of 30 subjects were “effective” and 4 (13.3%) were “ "Invalid".

  In the determination of effectiveness against itching, out of the 8 “invalid” subjects, 4 subjects had improved rashes. In 22 subjects who were judged to be “slightly effective” in the determination of effectiveness against itching, the reduction of pruritus and the improvement of rash were almost correlated.

  The composition of Example 1 showed an effect of reducing pruritus in patients with atopic dermatitis. Moreover, the composition of Example 1 showed the improvement effect of the rash in atopic dermatitis patients.

  According to the results of Test Example 1, the composition according to the present invention can improve the symptoms of atopic dermatitis, such as pruritus and rash. Many of the subjects said that the feeling of use was generally relaxing with a refreshing scent.

Test Example 2 Epidermis horny layer moisture content The skin dryness improving effect was tested. A certain amount of moisture is retained in the stratum corneum outside the skin. The stratum corneum that retains sufficient moisture has a barrier function that prevents external stimuli. In skin where the moisture content of the stratum corneum has decreased, that is, dry skin (dry skin), the barrier function of the skin is reduced, and it becomes easy to receive external irritation and to feel itching.

  The test subjects were 24 healthy people. The test subjects were divided into two groups of 12 persons, which were used as a test group and a control group, respectively. Test hot water was prepared by dissolving 30 grams of the composition of Example 1 in about 200 liters of hot water (about 40 ° C.). The control hot water was about 200 liters of hot water (about 40 ° C.) without the composition of Example 1. The test period was 4 weeks. The moisture content of the epidermal stratum corneum was measured by SKICON-200.

平均値±標準偏差（S.D.）、ｎ＝１２
前値： 試験１日前の測定結果である
＊ ： ｐ＜０．０５ （対、前値 対応のないt-test）
＊＊： ｐ＜０．０１ （対、前値 対応のないt-test）
♯ ： ｐ＜０．０５ （対、対照湯 対応のないt-test）
♯♯： ｐ＜０．０１ （対、対照湯 対応のないt-test） For example, Hachiro Tagami et al., “Measurement of moisture content of the epidermal stratum corneum by resistance measurement against high frequency”, Nisshakai, Vol. 90 (5), 445-447 1980. Table 5 shows the measurement results.

Mean value ± standard deviation (SD), n = 12
Previous value: Measurement result one day before the test *: p <0.05 (vs. t-test with no corresponding previous value)
**: p <0.01 (vs. t-test with no corresponding previous value)
#: P <0.05 (vs. t-test without control hot water)
##: p <0.01 (vs. t-test without control hot water)

  As shown in Table 5, the test water showed significantly higher values at the second and third weeks after the test than the measurement results at the second and third weeks of the control water (P < 0.05). In addition, the test water showed a significantly higher value than the measurement result of the fourth week of the control hot water at 4 weeks after the test (P <0.01). The composition of Example 1 showed the effect of increasing the moisture content of the epidermis stratum corneum.

  According to the results of Test Example 2, the composition of the present invention can improve skin dryness. Thus, the composition according to the present invention has a good moisturizing action and can improve skin pruritus caused by dry skin.

Test Example 3 Residual chlorine removal action The removal effect of free chlorine in tap water was tested. It is known that free chlorine causes skin irritation and causes a decrease in skin barrier function.
Control water was prepared by adding sodium hypochlorite solution to 40 ° C. tap water so that the free chlorine was 2 mg / L. Test water was prepared by dissolving 0.3 grams of the composition of Example 1 in about 300 milliliters of control water. Residual free chlorine concentration, combined chlorine concentration and total chlorine concentration in each solution were measured at each time point by diethyl-p-phenylenediamine (DPD) method according to the hygiene test method.

  The measurement results are shown in FIG. In the control water, the free chlorine concentration was almost constant (FIG. 1a). In the test water, a rapid decrease in the free chlorine concentration was confirmed (FIG. 1b). Thus, the composition of Example 1 showed the effect of removing free chlorine in water.

  According to the results of Test Example 3, the composition of the present invention has an effect of removing free chlorine. Thus, the composition according to the present invention suppresses a decrease in the skin barrier function that may occur due to free chlorine, and as a result, may have a protective effect on the skin barrier function.

Example 6 and Comparative Example 1
Each composition in Table 6 was prepared by dissolving chimpi extract powder, thyme extract powder and rooibos tea extract powder in purified water so as to have the composition shown in Table 6. In Table 6, chimpi extract powder, thyme extract powder and rooibos tea extract powder are the same as in Table 1.

Test Example 4 Skin moisturizing effect
The skin moisturizing effect was tested. Transepidermal water transpiration (TEWL) was used as an index of the skin moisturizing effect. Since TEWL indicates the amount of moisture transpiration, the lower the value, the more moisture transpiration from the skin is suppressed, and it can be evaluated that the skin barrier function is maintained.

  Ten healthy subjects aged 20 to 70 were used as subjects. Purified water was used as a negative control, and 0.2% acetylated hyaluronate Na (AcH: “sodium acetylated hyaluronate”, manufactured by Shiseido Co., Ltd.), which has been used in moisturization, was used as a positive control (Genji Imokawa, Selective Recovery) of Deranged Water-Holding Properties by Stratum Corneum Lipids. December, Vol. 87, No. 6 (1986): hereinafter referred to as “Document 1”). As the test drug, the compositions of Example 6 and Comparative Example 1 were used.

The TEWL measurement was performed according to the following procedure.
-A test subject sits in a chair in a temperature-controlled room at a temperature of 20 ± 2 ° C. and a humidity of 45-55%, and gently adjusts the skin condition for 20 minutes (Reference 1).
-After the skin is stabilized, TEWL before rough skin treatment is measured with an instrument (Tewameter, Cutometer MPA 580 (Integral Co., Ltd.)).
・ Inject 5 mL of 5% sodium lauryl sulfate (SDS) into a well, fix it on the forearm test site, and apply for 10 minutes by immersion (treatment of rough skin) (T. OKA, M, Skin-softening effect of acetylhyaluronate on stratum corneum. J. cosmet, Sci, 50, 171-184 (May / June 1999): hereinafter referred to as “Document 2”).
-After rough skin treatment, all wells are removed from the forearm test site, the application site is washed thoroughly with water until the slime of the SDS disappears, and the moisture is wiped off with a towel.
-Immediately thereafter, 5 mL each of the test drug or the like is injected into the well, fixed to the forearm test site, and dipped for 10 minutes (Reference 2).
-After dip coating, all wells are removed from the forearm test site, and the test drug or the like on the coating site is wiped off with a Kimwipe.
・ Measure TEWL 10 minutes after removal of the test drug.

The evaluation of TEWL was performed by calculating a measured value after applying the test drug ((measured value after applying the test drug) / (measured value before rough skin treatment)) with respect to the measured value before the rough skin treatment. The results are shown in Table 7 and FIG.

  As shown in Table 7 and FIG. 2, the TEWL of the composition according to the present invention (Example 6) is higher than that of the positive control (acetylated hyaluronic acid Na) and Comparative Example 1 (two types of chimpi and thyme). Also showed a statistically significantly lower value.

  According to the results of Test Example 4, the composition according to the present invention is higher in moisturizing action and skin barrier function than acetylated hyaluronic acid Na, which is known as a moisturizing component, and two combinations of chimpi and thyme. Has protective and improving effects.

Claims (7)

  A composition for toiletry products comprising citrus peel extract, thyme extract and rooibos tea extract.   The composition according to claim 1, wherein the citrus peel extract is a chimpi extract.   The composition according to claim 1 or 2, wherein the toiletry product is selected from the group consisting of soap, lotion, and bath preparation.   The composition according to claim 1 or 2, wherein the toiletry product is a bath preparation.   The citrus peel extract contains 0.01 to 20% by mass, thyme extract 0.01 to 10% by mass, and rooibos tea extract 0.01 to 10% by mass per composition amount. A composition according to claim 1.   The composition according to claim 5, comprising 0.1 to 10% by mass of citrus peel extract, 0.05 to 3% by mass of thyme extract, and 0.01 to 1% by mass of rooibos tea extract per amount of the composition material. object.   A toiletry product comprising the composition according to any one of claims 1 to 6.

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