JP2008169196A - External preparation for skin - Google Patents

Abstract

<P>PROBLEM TO BE SOLVED: To provide an external preparation for skin which utilizes a natural product and can be used safely, giving tension to the skin, preventing skin disease dermatosis, having higher skin beautifying effect and anti-aging effect, etc. <P>SOLUTION: The external preparation for skin is composed of appropriately formulated Folium Rhododendron anthopogonoises and honey, and contains components which give tension to the skin, improve skin function and prevent skin disease. The extract from the folium Rhododendron anthopogonoises contains components which suppress sebum, smell of aged person, itching, dandruff, head sebum, etc. The extract from the folium Rhododendron anthopogonoises is a component at least soluble in either one of water or alcohol. The extract from the folium Rhododendron anthopogonoises is formulated in a cream or a pack preparation or in a gel of the poultice preparation. <P>COPYRIGHT: (C)2008,JPO&INPIT

Description

  The present invention relates to an external preparation for skin which is applied or stuck to the skin to give a cosmetic effect or other medicinal effects.

  Conventionally, a skin external preparation having a cosmetic effect or the like includes various components according to the purpose. For example, the cosmetic of Patent Document 1 contains a cosmetic base material, honey, an extract of royal jelly with an organic solvent, and an organic solvent of propolis, water, or an extract by a supercritical method. As an effect of this cosmetic, a high skin roughness suppressing effect can be obtained due to high moisturizing property and high antioxidant property.

The anti-oxidant and external preparation for skin of Patent Document 2 contain an extract obtained from Reika Kozo or Kuranishiki. As an effect of this external preparation for skin, it is possible to obtain the effect of preventing skin aging phenomenon including wrinkles.
JP 2002-173413 A JP 2003-212779 A

  The above Patent Documents 1 and 2 disclose moisture retention and antioxidant action by honey, and disclose the antioxidant action of fiery persimmon, but give skin tension and prevent skin diseases, whitening effect Etc. are also disclosed, and a skin external preparation or the like that can achieve the effect of preparing a well-balanced skin is not disclosed or suggested. Therefore, an external preparation for skin that can meet these demands has been demanded.

  The present invention has been made in view of the above-mentioned problems of the prior art, can be used safely using natural products, gives skin tension, prevents skin diseases, and has a higher skin-beautifying effect. Another object is to provide an external preparation for skin having an anti-aging effect.

  The present invention is an external preparation for skin containing intense incense, particularly for imparting tension to the skin, improving skin function, suppressing sebaceous gland secretion and reducing melanin, and preventing skin diseases. Contains. Furthermore, it contains ingredients that suppress sebum, old man odor, itching, dandruff, head oil, and the like. Moreover, the thing containing the extract and honey and other components which can be obtained from a fragrant bud may be used.

  Examples of the extraction solvent for obtaining the extract of the fragrant potato include water or lower alcohols such as ethanol, propanol and butanol, and polyhydric alcohols such as 1,3-butylene glycol, propylene glycol, glycerin and dipropylene glycol. Or a mixture thereof. Extraction may be performed by heating at a low temperature and at a normal temperature. Extraction at a low temperature is preferable in terms of effect. The obtained extract may be appropriately purified and filtered, or may be a liquid concentrated by a conventional method, or may be solidified and powdered by dry solidification, freeze drying or the like and mixed.

  Skin external preparations are cosmetic liquids, creams, packs, poultices, and the like, and skin external preparation base materials suitable for each are used, and the skin external preparation base material contains incense and honey. When the skin external preparation is a cream, the blended amount of the extract of fragrance is 1% to 10% by weight, but the optimal amount is 2 to 4%, and the blended amount of honey is 0 to 1%. However, the optimum amount is 0-0.3%. When the external preparation for skin is a beauty pack, the blended amount of Gankou extract is 30% to 70%, the optimum amount is 40% to 60%, and the blended amount of honey is 30% to 70%, the optimum amount is 40%. ~ 60%. When the external preparation for skin is a poultice pack, the blending amount of the fragrant extract in the pack agent is 0.005% to 15%, the optimal amount is 0.05% to 10%, and the blending amount of honey is 0.00. 005% to 15%, optimum amount 0.05% to 10%. In addition to this, the external preparation for skin may be pharmaceuticals, hair materials, and the like. Moreover, you may mix | blend in the gel of a poultice.

  The external preparation for skin of the present invention is applied to or stuck to the skin to give tension to the skin, prevent sagging of the skin, suppress sebum and head oil, and suppress the odor of old people. It also improves the condition of the scalp and reduces dandruff. Other skin functions are improved, skin diseases are prevented, itching is suppressed, skin beautifying effects and skin peeling are prevented. Further, by adding honey, whitening skin effect and tension can be imparted, drying can be prevented, and a bactericidal effect can also be obtained.

  According to the present invention, these different effects can be obtained simultaneously and synergistically, and the skin is effectively adjusted in a balanced manner. In addition, the incense and honey are natural products that can be used safely and give the user a sense of security.

  Hereinafter, embodiments of the present invention will be described in detail. The cosmetic which is an embodiment of the external preparation for skin of the present invention is a cream applied to the skin, and contains a base for external preparation for skin and an extract of intense incense. Moreover, it contains a honey suitably.

  Here, a description will be given of Reika. Reika is called Rhodendron anthopogonoides Maxim and has been treasured as a folk medicine in Tibet. In recent years, it has been confirmed that it has an excellent antioxidant effect.

  Examples of the extraction solvent for obtaining the extract of Gankou include lower alcohols such as water, ethanol, propanol and butanol, polyhydric alcohols such as 1,3-butylene glycol, propylene glycol, glycerin and dipropylene glycol, Or a mixture thereof or the like can be mentioned. Among these, water alone, a mixture of water and ethanol, a mixture of water and 1,3-butylene glycol is preferable, and the ratio of ethanol or 1,3-butylene glycol to water is 1: 1 to 1:99 ( The volume ratio) is more preferable. Extraction may be performed by heating at a low temperature and at a normal temperature. Extraction at a low temperature is preferable in terms of effect. The obtained extract may be appropriately purified and filtered, or may be concentrated and dried and solidified by a conventional method.

  Honey is a flower nectar collected by bees and is said to have a moisturizing effect or an effect of alleviating the adhesion of microorganisms, and has a whitening effect and a skin beautifying effect.

  Next, the components of the cream of this embodiment will be described. For example, the blending components include stearic acid (stearic acid 850, 750), beeswax, cetyl alcohol, lanolin, solid paraffin, petrolatum, jojoba oil, castor oil, squalane, oleic acid, olive oil, horse oil, liquid paraffin as oil components. Silicon oil, MOD (octyldodecyl myristate), etc. can be used. As the humectant, glycerin, 1.3 butylene glycol, sorbitol, propylene glycol or the like is used. As an emulsifier, stearyl alcohol, stearic acid monoglycerin ester, polyethylene glycol monostearate, ethylene glycol monostearate, polyoxyethylene cetyl ether, polyoxyethylene sorbitan monooleate and the like are blended, and these are mixed with purified water. Further, as appropriate thickeners, carboxyvinyl polymer, xanthan gum, polyvinyl alcohol, etc. may be blended, as preservatives, methyl paraben, butyl paraben, propyl paraben, etc., as other additives, arginine, trehalose, sodium hyaluronate, citric acid, etc. Acid, sodium citrate, sodium hydroxide, potassium hydroxide, calcium hydroxide, disodium edetate and the like are preferably blended. These blending ratios may be blended according to known examples in accordance with the intended use.

  In addition, although the compounding quantity of an intense perfume extract is 1%-10%, the optimal quantity is 2-4%. The amount of honey is 0 to 1%, but the optimum amount is 0 to 0.3%.

  Next, the adjustment method of this cream is demonstrated. A mixture of each component of a general oil phase and a mixture of each component of an aqueous phase are heated to 70 ° C. and completely dissolved. Then, the heat-dissolved oil phase component is added to the heat-dissolved oil phase component and emulsified with an emulsifier. The emulsion is cooled and filled into a container to obtain a cream product.

  According to the cream of this embodiment, it gives tension to the skin, stretches wrinkles, suppresses sebum, suppresses sebum, suppresses old man odor, improves scalp, removes sagging, suppresses dandruff Effects such as improvement of skin diseases, suppression of itchiness, effect of beautiful skin, prevention of skin peeling, etc. are expected.

  Furthermore, by adding honey to the fragrant cocoon extract, the two components efficiently act on the skin, and the anti-aging effect such as prevention of wrinkles and the skin whitening effect are enhanced. And the effect of reverberant candy and honey can be demonstrated synergistically and the skin can be well-balanced. Incense candy and honey are natural products and can be used safely, giving the user a sense of security.

  In addition, the skin external preparation of this invention is not limited to the said embodiment, Applications can be freely selected, such as the cosmetics used for a face, a scalp, and other skin, a beauty pack, or a poultice for poultice. In the case of a beauty pack, the blended amount of the extract of the incense persimmon is 30% to 70%, the optimum amount is 40% to 60%, and when blending honey, the optimum amount is 30% to 70%. 40% to 60%. In the case of a poultry pack, the blending amount of the perfume extract is 0.005% to 15%, the optimal amount is 0.05% to 10%, and when blending honey, 0.005% to 15%, The optimum amount is 0.05% to 10%. In addition, you may use for a pharmaceutical, a hair charge, etc.

  Next, a monitor test was performed on the cream according to the embodiment of the present invention. In the monitor test, 6 persons used the cream of the external preparation for skin of the present invention, and 16 persons used the external preparation for skin of the present invention for the pack. The average value of monitor evaluation when using cream is shown in FIG. The base material of the cream was a general one, and a base material having no special medicinal effect was used, and the base material containing 2% of the fragrant extract and 0.3% of honey was used. Moreover, the result of using the pack agent of this invention is similarly shown in FIG. The incense extract in the pack is 50% and honey 30%.

  The scoring method was evaluated by the degree of improvement (%) for 12 items such as moist feeling, whether the skin condition was improved by using this cream or pack. The content of improvement (%) is subjective, but no change or unknown range is 0 to 20%, almost no change is 20% to 40%, and 40% if you feel a little improvement The response was in the range of 60% to 80% when feeling improved, and 80% to 100% when feeling very improved.

  As a result, when cream is used, the average value (%) shows 50% or more in most items, indicating that many people feel that the skin condition has been improved. In addition, when used in a pack, almost all items showed 75% or more, indicating that many people feel that their skin condition has been greatly improved. Table 1 shows the effect of the questionnaire items.

  Next, a monitor test was performed on the essence containing the extract obtained from the perfume cake of the embodiment of the present invention. Fourteen men and women with skin problems such as dryness were divided into two groups, and each of the following A and B skin improvers was used for 8 days. The questionnaire was filled in with the following A and B skin-improving agents applied to the entire face after washing every night and washed off after 30 minutes.

  In addition, as a method of detecting odor, the sides of both noses were wiped with fingers before washing the face in the evening, and it was obtained. A questionnaire shows that the effectiveness with respect to an evaluation item is so high that a number becomes large in the stage of 1-5.

  As a result, it was confirmed that the skin improvement agent A containing honey has a greater effect on the questions 1 to 5. In addition, it was confirmed that the essence of the fragrant extract containing no honey is effective in improving itching and body odor.

  Next, a monitor test was performed on the essence containing the extract obtained from the perfume cake of the embodiment of the present invention. In the monitor test, 12 adult female healthy subjects (age 31-51 years old, mean age ± SD :) who fully explained the purpose of the test etc. to the subjects in writing and verbally and obtained written consent. 45.0 ± 6.9 years old).

  First, the effect of the essence of the perfume extract by a single application test was examined. The experimental method is as follows.

  Regarding the sebaceous gland secretion inhibitory action, each subject who had completed sufficient face washing and wiping was kept quiet for 30 minutes in an environment of room temperature 22-23 ° C. and indoor humidity 50%, and then the CUTOMETER MPA 580 was placed on each subject's forehead 2 cm square. The Sebumeter SM815 probe attached to (Integral Co., Ltd.) was brought into close contact for 30 seconds, and the secretion amount of fat was measured. Then, after applying 1 g of the essence of the fragrant extract similar to the skin improving agent B of Example 2 to each subject's forehead 2 cm square and keeping it still in the same room for 30 minutes, after sufficiently wiping off, The amount of fat secretion at the application site and the non-application site was measured with the same measuring device. The measurement was performed three times for each part.

  Next, it experimented about the whitening effect | action of a perfume extract. Each of the subjects who had finished washing and wiping both hands with the same essence as the skin improving agent B of Example 2 was applied to each subject under the environment of room temperature 22-23 ° C. and indoor humidity 50%. After being kept quiet for a minute, the Mexometer probe attached to the CUTERTER MPA580 was brought into close contact with 2 cm square of the back of each subject's left hand for several seconds, and the melanin value was measured. Then, after applying 1 g of the essence of the fragrance extract similar to the skin improving agent B of Example 2 to each subject's 2 cm back of the left hand and keeping it in the same room for 30 minutes, it was thoroughly wiped off. The melanin value of the former part of the application site and the non-application part of the right hand was measured with the same measuring device. The measurement was performed three times for each part.

  Next, it experimented about the skin elasticity increase | augmentation effect | action of a perfume extract. In the same manner as in the above experiment, each subject after sufficient washing and wiping of both hands was kept at room temperature of 22-23 ° C. and indoor humidity of 50% for 30 minutes, and then placed on the back of the subject's left hand 2 cm square. A probe for measuring skin viscoelasticity of CUTERTER MPA580 was brought into close contact for several seconds, and the elasticity was measured. Then, after applying 1 g of a essence of a perfume extract similar to the skin improver B of Example 2 to each subject's 2 cm square on the back of the left hand and keeping it resting in the same room for 30 minutes, after sufficiently wiping off The elasticity of the application site and the back of the non-application part of the right hand was measured with the same measuring device. The measurement was performed three times for each part.

  Next, a continuous coating test was performed. From the day when the single application test was carried out, before going to bed at night in each subject's home, 1 g of a beauty liquid of the same incense extract as the skin improver B of Example 2 was applied to each of the forehead and back of the left hand. The coating was applied to a 2 cm square for 7 consecutive days, and the following measurements were performed on the day after the final coating date.

  Regarding the sebaceous gland secretion inhibitory action, each subject who has completed sufficient facial cleansing and wiping has been kept calm for 30 minutes in an environment of room temperature 22-23 ° C. and indoor humidity 50%. The Seumeter SM815 probe attached to the CUTERTER MPA580 (manufactured by Integral Co., Ltd.) is closely attached to the 2 cm square of the forehead where 1 g of the salmon extract cosmetic liquid 1 g has been applied and the 2 cm square of the non-applied part of the forehead for 30 seconds. The amount of secretion was measured. The measurement was performed three times for each part.

  Regarding the whitening effect, each subject who had sufficiently cleaned and wiped both hands was kept at a room temperature of 22 to 23 ° C. and an indoor humidity of 50% for 30 minutes. In addition to the 2cm square of the back of the left hand that continued to be applied with the same essence as the skin improver B of the skin improvement agent B, the Mexometer probe attached to the CUMETER MPA580 is closely attached to the 2cm square of the back of the right hand, which is not applied. The melanin value was measured. The measurement was performed three times for each part.

  Regarding the skin elasticity increasing effect, each subject who had sufficiently washed and wiped both hands was kept at room temperature of 22 to 23 ° C. and an indoor humidity of 50% for 30 minutes. The skin viscoelasticity of CUTERTER MPA580 is applied to the 2 cm square of the back of the left hand and the 2 cm square of the back of the right hand of the non-applied part. The measurement probe was brought into close contact for several seconds, and the elasticity was measured. The measurement was performed three times for each part.

  About the skin stratum corneum water retention ability increasing effect, after each subject who had sufficiently washed and wiped both hands was kept at room temperature of 22-23 ° C. and indoor humidity of 50% for 30 minutes, over the past 7 days The skin stratum corneum moisture of SKICON-200EX (made by IBS Co., Ltd.) was applied to each 2 cm square of the back of the left hand in which each subject continued to apply 1 g of a beauty essence of a perfume extract similar to the skin improver B of Example 2. The probe for measurement was brought into close contact for several seconds, and the conductivity of the skin stratum corneum was measured. The measurement was performed three times for each part.

  Statistical analysis of the above experiments is based on the average values of 12 cases obtained at the same site before and after application in the single application test, and each of the application site and the non-application site in the continuous application test. The Student t test was performed on the average values of the 12 cases obtained in the above.

  As a result, the following was found. First, as to the sebaceous gland secretion inhibitory action, as shown in FIG. 3, the amount of fat secretion in the forehead is about 40% significant by applying the intense incense extract in both the single application test and the continuous application test. Declined.

  In addition, as shown in FIG. 4, the melanin value lowering action, which is a whitening effect, was not significantly changed by a single application of the incense extract essence, In the continuous application, the melanin value was reduced by about 10% compared to the non-application part.

  As for the skin elasticity increasing action, as shown in FIG. 5, no significant change was observed in the skin elasticity in both the single application and the continuous application.

  Further, as shown in FIG. 6, the stratum corneum water retention ability of the left back after continuous application is about 20% higher than that of the non-application area, although it is not statistically significant. The tendency to do was recognized.

  As a result of the single and continuous application tests in this experiment, a remarkable suppression of fat secretion was observed, and the melanin value was also significantly reduced by continuous application. It was found that it has the effect of suppressing excessive secretion. Since excessive secretion of sebum is considered to cause acne, seborrheic eczema, dandruff, oily skin, oily hair, alopecia, etc., it is extremely useful in preventing the above-mentioned various skin symptoms and whitening. Judged to be high.

  On the other hand, although it was not statistically significant, it was suggested that it was effective for the firmness and moisture of the skin because the stratum corneum water retention ability tended to increase by continuous application of the extract of fragrant potato. .

It is a graph which shows the average of each evaluation item as a result of using the cream of one Example of this invention. It is a graph which shows the average of each evaluation item as a result of using the pack of one Example of this invention. It is a graph which shows the influence of the amount of skin fat secretion of the result of using the intense perfume extract cosmetic liquid of the other Example of this invention. It is a graph which shows the melanin value of skin as a result of using the intense perfume extract cosmetic liquid of the other Example of this invention. It is a graph which shows the influence on skin elasticity of the result of using the intense perfume extract cosmetic liquid of the other Example of this invention. It is a graph which shows the influence of the conductance (conductance) of a skin stratum corneum as a result of using the intense perfume extract cosmetics of another Example of this invention.

Claims (7)

  An external preparation for skin characterized by containing incense and honey.   An external preparation for skin containing an extract obtained from Gankou and having at least one of sebaceous gland secretion inhibitory action, skin melanin value reducing action, and skin elasticity increasing action.   The external preparation for skin according to claim 1, which contains an extract obtained from Gankou.   The external preparation for skin according to claim 2 or 3, wherein the extract obtained from the incense persimmon is a component that dissolves in at least one of water and alcohol.   The external preparation for skin according to claim 4, wherein the extract obtained from the incense persimmon is blended in a cosmetic liquid.   The external preparation for skin according to claim 4, wherein the extract obtained from the incense persimmon is blended with a cream or a pack.   The external preparation for skin according to claim 4, wherein the extract obtained from the incense persimmon is blended in a gel of a poultice.

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