KR20190040426A - Cosmetic composition for preventing scalp aging and hair loss - Google Patents

Abstract

The present invention relates to a cosmetic composition having effects of preventing and alleviating scalp aging and preventing hair loss and, more specifically, to an anti-hair loss agent composition containing menthol, salicylic acid, adenosine, and dexpanthenol. The use of an anti-hair loss agent containing menthol, salicylic acid, adenosine, and dexpanthenol of the present invention can prevent, alleviate, and avoid scalp aging, and improve the anti-hair loss effect thereby.

Description

TECHNICAL FIELD The present invention relates to a cosmetic composition having an effect of preventing and alleviating scalp aging,

The present invention relates to a cosmetic composition having an effect of preventing and alleviating scalp aging and preventing hair loss.

As modern medicine develops, medical technology has been developed to treat and cure a large number of diseases that have a life-threatening effect on life. However, as society becomes more and more aesthetic, hair loss becomes a social issue in recent years.

The hair of the human body has about 100,000 to 150,000 different cycles, and grows or falls through growth, regrowth, and pauses. Hair loss generally means that hair growth rate in the growing period is shortened and hair in the retrograde period or resting period is large And the number of abnormal hair dropouts is increased.

The cause of known hair loss may be influenced by various factors such as age, season, race, physiological factors, and disease, but it can be affected by 1) male hormone hyperactivity, 2) excessive sebaceous secretion, 3) 4) depression of the scalp due to peroxidation and bacteria, 5) genetic factors, 6) aging, and 7) stress.

In the early stages of hair loss, dandruff diseases such as dandruff and seborrheic dermatitis are widely known to be accompanied by typical early symptoms. In particular, scalp inflammation is caused by various pollutants, skin hypersensitivity to bacteria, The genetic factors such as nervous system disorder, blood circulation disorder, excessive sebum production caused by abnormal circulatory system, nutritional deficiency of hair follicle, allergy, bacterial infection, hormone effect, various pollution, It is known that a combination of mental and social factors and aging of modern people who are frequently exposed to environmental factors and excessive stress such as shampoo, soap, mousse, hair gel, hair spray, permer, dyeing, hair dryer and detergent are known.

These factors are expected to increase the demand for hair loss prevention and hair loss patients who want to keep wool as the hair loss patients are soaring.

However, there are various hair loss products including effective ingredients such as blood circulation promotion, hair root enhancement effect, scalp moisturizing effect, anti-dandruff effect, antioxidant effect, hair growth period extension effect and suppression of male hormone function. However, In terms of efficacy, it has not yet been proven to have significant effects, and side effects may be raised.

Accordingly, anti-hair-loss agents using natural extracts with less side effects have been developed.

Korean Patent No. 10-1780692 (Patent Document 1) can be exemplified as a conventional technology for an anti-hair loss agent using such a natural extract. The patent discloses a composition for preventing hair loss or promoting hair growth, comprising a mixed extract of green tea and amaranthus, or a mixed extract of green tea, green tea and hibiscus as an active ingredient, and discloses a natural combination extract. The effectiveness is significantly different.

KR 10-1780692 B1 (September 27, 2017)

Disclosure of the Invention The present invention has been made to solve the above-mentioned problems, and it is an object of the present invention to provide a hair loss prevention composition which prevents, alleviates and prevents hair loss by preventing, alleviating and preventing hair aging, And an anti-hair loss agent using the same.

SUMMARY OF THE INVENTION The present invention has been made to solve the above-mentioned problems of the prior art,

Menthol, salicylic acid, adenosine, and dexpanthenol.

In addition, in the present invention, the composition provides an anti-depressant composition having an effect of alleviating, preventing and preventing scalp aging.

In addition, the composition of the present invention may further comprise at least one surfactant selected from the group consisting of: 0.05-2 wt% menthol, 0.05-2 wt% salicylic acid, 0.01-0.5 wt% adenosine, and 0.05-15 wt% dexpanthenol, There is provided an anti-depilator composition for relieving pain.

In the present invention, the composition according to the present invention may further comprise at least one selected from the group consisting of retinol, tocopherol, ascorbic acid, collagen, an extract of Fusarium oxysporum, an extract of Fusarium oxysporum, an extract of Fusarium oxysporum, an iris root extract, a thistle flower / leaf / stem extract, a propolis extract, Wherein the composition further comprises at least one additional component selected from the group consisting of hos < RTI ID = 0.0 > fats. ≪ / RTI >

Also in the present invention, the additional component provides an anti-depilatory composition having a total content of 0.01 to 20% by weight based on the total weight of the composition.

Also provided is a cosmetic product for preventing hair loss, which comprises the composition of the present invention and is manufactured from a cream, lotion, essence, serum, toner, tonic, and mist.

Use of an antioxidant containing menthol, salicylic acid, adenosine, and dexpanthenol of the present invention can prevent, alleviate or prevent scalp aging, thereby improving hair loss prevention effect.

1 is a graph showing changes in hair loss preventing effect, hair size, and hair density before and after use of the hair loss preventing agent of the present invention.

Hereinafter, embodiments of the present invention will be described in detail. However, it should be understood that the present invention is not limited thereto, and the present invention is only defined by the scope of the following claims.

In the following description of the present invention, a detailed description of known functions and configurations incorporated herein will be omitted when it may make the subject matter of the present invention rather unclear.

In describing the components of the present invention, the terms first, second, A, B, (a), (b), and the like can be used. These terms are intended to distinguish the constituent elements from other constituent elements, and the terms do not limit the nature, order or order of the constituent elements.

The terms " about, " " substantially, " and " degree ", etc. used to describe the present invention should be understood to include both manufacturing and material tolerances inherent to the stated meanings, And is used to prevent unauthorized use by an unscrupulous infringer of an explicit or absolute number for the purpose of facilitating the understanding of the present invention.

An anti-depressant composition for preventing, alleviating and preventing scalp aging according to an embodiment of the present invention may include menthol, salicylic acid, adenosine, and dexpanthenol.

The menthol is a component used for stomach cramps and toothache, and is good for pain and inflammation, and has an effect of cooling the scalp, so that the feeling of cooling of the scalp can be added.

The menthol preferably contains 0.05-2% by weight, more preferably 0.1-1.0% by weight, based on the total weight.

When the content of menthol is less than 0.05% by weight, the efficacy and the effect are insignificant. When the content of menthol is more than 2% by weight, excessive cooling or irritation may occur and the formulation may be unstable.

The salicylic acid is widely used for skin-related diseases such as acne, dandruff, keratin and corn, and has a property of softening the anti-inflammatory and scalp keratin so as to remove old keratin and waste products remaining inside the pores You can do it.

Salicylic acid preferably contains 0.05-2% by weight based on the total weight of the composition, and if it exceeds 0.1-1% by weight, skin irritation may occur.

The adenosine is a component which promotes the synthesis of collagen, alleviates wrinkles and improves skin elasticity.

The adenosine preferably contains 0.01-0.5 wt%, more preferably 0.02-0.2 wt%, based on the total weight.

If the content of adenosine is less than 0.01% by weight, the effect and the effect are insignificant and the effect of improving the elasticity of the scalp is insignificant. If the content exceeds 0.5% by weight, stability in the product deteriorates and the effect is not improved. There may be a possibility of occurrence.

Dex Panthenol is a protein that is converted into vitamins after being absorbed into the body. It can prevent inflammation and itching, soften hair, and enhance hair strength.

The dexpanthenol preferably contains 0.05 to 15% by weight, more preferably 0.1 to 10% by weight, based on the total weight.

When the content of dex-panthenol is less than 0.05% by weight, the efficacy and the effect are insignificant. When the content exceeds 15% by weight, the effect is not enhanced and the usability and stability may be poor.

To further improve the efficacy of the antioxidant composition capable of preventing, alleviating and preventing the scalp aging, retinol, tocopherol, ascorbic acid, collagen, an extract of anthocyanin, an extract of a common ginseng root, an extract of an iris, a thistle flower / Extract, propolis extract, horseradish extract, Jeju balsam extract, and hosepat.

The retinol is a kind of vitamin A, and plays an important role in maintaining the original function of the epidermal cells of the skin. Especially, it is an effective ingredient for improving wrinkles and preventing skin aging.

The tocopherol is a kind of vitamin E which is a fat-soluble vitamin. It has an antioxidant effect and inhibits the oxidation of the unsaturated fatty acid constituting the cell membrane, thereby preventing damage to the cell membrane and further damage to the tissue. It is a highly effective ingredient.

Ascorbic acid is one of the water-soluble vitamins and is an antioxidant that is vitamin C. It protects the body from active oxygen to prevent oxidation of the cells and also plays an important role in protecting the skin from ultraviolet rays.

When the collagen is added to cosmetics, the moisturizing power is remarkably increased, and in particular, the texture is improved and the composition can improve the feeling of use.

The above-mentioned Ishigaki is an Araliaceae plant which is a reclaimed land of Jeju Island.

It has been known that it is used for medicinal purposes since the Goryeo period, and the shells of roots, stems and branches are called ogapi, the leaves are called ogabi, Acanthopanax nucifera extract has excellent antioxidant and anti-inflammatory properties.

The extracts of the common astringent ginseng have no cytotoxicity, and are excellent in anti-inflammatory effect by inhibiting various cytokines and NO activity mediated by inflammatory reaction, and can be effective in preventing skin aging and strengthening skin barrier due to high antioxidant effect .

The iris is distributed in Korea, Japan, and China. It is a perennial herb that grows in a pond or a ditch. In oriental medicine, the function of an organ such as eyes, nose, mouth, ear, urethra and anus in our body Helps to release toxins from the body and has a detoxifying function, antimicrobial and anti-inflammatory effect, "a tradition of bathing hair with boiled water by putting irises on a monolayer". Especially, the root of iris is excellent for the improvement of fragile constitution, and it is known that essential oil of iris can solve blood circulation, pain, fatigue, and especially antioxidant efficacy is excellent.

The thistle is a perennial plant of Asteraceae. The flower / leaf / stem extract is applied to the skin by applying a thistle outpost extract that promotes ARE protein activity related to the antioxidant protein Nrf-2, Maintains homeostasis and prevents skin aging by active oxygen.

The propolis is excellent in organic matter and minerals. Especially, minerals, vitamins, amino acids, fats, organic acids, flavonoids and the like play an important role in cell metabolism, terpenes and the like have anticancer activities, and flavonoids help health promotion give. This propolis has anti-inflammatory, antioxidant, immunity enhancing effects.

The Mahi-hyeon is also called a horsetail, in other words, a leaf-shaped horsetail that hits the teeth of a horse and eats salmon. It is known that there are many omega - 3 fatty acids, which are a type of unsaturated fatty acid, and this extract has excellent antioxidative and anti - inflammatory properties.

The bamboo sage is a monocotyledonous plant of the paddy field distributed in Korea and Japan. In particular, the bamboo sage berry in Jeju is cold and snowy, has a life span of 60-120 years, and is effective in preventing cancer, antioxidation and obesity It is known, and especially has a very high moisturizing effect.

The hose fat is an excellent antioxidant and anti-inflammatory ingredient, and can maintain skin homeostasis and prevent skin aging by promoting ARE activity associated with antioxidant protein Nrf-2.

In addition, the extracts of the above-mentioned extracts such as anthocyanin extracts, common astringent extracts, iris root extracts, thistle flower / leaf / stem extracts, propolis extracts, It is desirable that Jeju Island, which is a clean area designated as Biosphere Reserve Area, is a native area.

The total content of retinol, tocopherol, ascorbic acid, collagen, jujube extract, common astringent juice extract, iris root extract, thistle flower / leaf / stem extract, propolis extract, 0.01-20% by weight, more preferably 0.1-10% by weight, is further included.

In summary, the anti-depressant composition according to the present invention is excellent in efficacy as an anti-depilation agent, and can prevent or alleviate the aging of the scalp, thereby alleviating and alleviating hair loss which can be accelerated thereby. Will be self-evident.

Also, the anti-depressant composition is prepared in the form of a cream, lotion, essence, serum, toner, tonic, mist, etc., and is applied to the scalp to make the scalp healthy. Especially, the anti-depilator composition can prevent, Can be used.

Hereinafter, the present invention will be described further by way of Production Examples and Test Examples. These examples are for further illustrating the present invention, and the scope of the present invention is not limited to these examples.

Manufacturing example

Preparation of Example 1-7 and Comparative Example 1-2

According to the composition ratios of Production Example 1-7 and Comparative Example 1-2 described in the following Table 1, purified water, glycerin, butylene glycol, 1,2hexanediol, disodium edetate were dissolved and heated to about 70 ° C To prepare solution 1, and the solution 1 was mixed with a mixture of caprylic / capric triglyceride, triethylhexanone, cetearyl alcohol, cyclopentasiloxane, palmitic acid, stearic acid, cyclohexasiloxane, Sorbate 60, PGI-100 stearate, glyceryl stearate, and sorbitan stearate were added and heated to about 70 ° C to dissolve them to prepare solution 2. The solution 2 thus prepared was added to Solution 1, mixed and emulsified. After cooling, components 3 were added and uniformly mixed to prepare an anti-depilation composition having an effect of alleviating scalp aging.

Test Example  One

The hair loss inhibitor, which has the effect of preventing, alleviating and preventing scalp, prepared according to the above Table 1 was applied to 18 adult male and female subjects each morning and evening. After 6 months, , Hair thickness and hair density were measured according to a predetermined evaluation method, and the average value was calculated and evaluated. The results are shown in Table 3 below.

1) Measurement of rate of change of hair loss after hair washing

The total amount of hair removed after hair washing after 6 months of use and before use was 2 for each of 18 male and female adults who had hair loss phenomenon in the hair loss prevention agent having the effect of preventing, And evaluated according to the evaluation criteria shown in Table 2 below. The results are shown in Tables 3 to 5.

As can be seen from the above Table 3, it can be seen that Examples 1 to 7 using the anti-hair loss agent capable of preventing, alleviating, and preventing scalp aging of the present invention significantly reduced the number of dropouts than Comparative Examples 1 and 2 .

2) Hair diameter (nm)

Folliscope 4.0 (Lead M, Korea), a device for analyzing the characteristics of hair based on photographs taken using a high resolution digital close-up camera, was used to measure the thickness of the hair by phototrichogram. Was used to measure the test site.

The measurement method used the scalp of a certain area (1 cm 2), and the average value of the thicknesses of five hairs in the area was used as evaluation data. The results are shown in Table 4 and FIG.

As can be seen from the above Table 4, it can be seen that the hair thicknesses of Examples 1 to 7 using the hair loss preventing agent that can prevent, mitigate and prevent the scalp aging of the present invention are significantly larger than those of Comparative Examples 1 and 2.

3) Hair density measurement (Hair diameter, nm)

Folliscope 4.0 (Lead M, Korea), a device for analyzing the characteristics of hair based on photographed photographs using a high-resolution digital close-up camera, was used to measure the hair density, which was measured by phototrichogram. Was used to measure the test site.

The number of hairs in the area was used as the evaluation data. The results are shown in Table 5.

As can be seen from Table 5, it can be seen that the hair densities of Examples 1 to 7 using the anti-hair loss agents that prevent, mitigate and prevent the scalp aging of the present invention are significantly higher than those of Comparative Examples 1 and 2. In the case of the comparative example, the density of the hair was not changed before use and after 6 months of use, while Examples 1 to 7 increased to 101-122% from the initial value.

Test Example  2

The hair loss preventive agent having the effect of preventing, alleviating and preventing scalp produced according to the above Table 1 was applied to each of nine adult males and females in the morning and evening after their hair was wound. After 6 months, Moisture content was measured according to a predetermined evaluation method, and the results were as shown in Tables 6 and 7 below.

1) Hairline elasticity measurement

Using the point that the scalp becomes less elastic as the scalp ages and the hairline, which is the boundary between the forehead and the head, is hit, the evaluation method for scalp elasticity measures the hairline elasticity. As a measuring instrument Cutometer CM580 was used and the area of the forehead hairline was measured.

The measurement was performed at the same site before and after the use of the hair loss preventing agent to prevent, mitigate and prevent the scalp aging according to the present invention, and R ² (skin re-elasticity) value was used as skin elasticity evaluation data. The R ² value is the overall elasticity, which means that the closer to 1 the more elastic the skin.

As shown in Table 6, it can be seen that Examples 1 to 7 using the antioxidant preventing, mitigating and preventing anti-aging agent of the present invention significantly increased the elasticity of the hairline as compared with Comparative Examples 1 and 2. In the case of Comparative Examples 1 and 2, the density of the hair was changed to 98% and 108% before use and 6 months after use, whereas Examples 1 to 7 increased to 112-147%.

2) Scalp Moisture Specific

The moisture content of the scalp was measured using a Corneometer CM825 (Courage-Khazaka electronic GmbH, Germany). Measurements were made three times through a sensor with a corneometer probe on the skin, and the average value was used as the skin moisture content evaluation data.

The Corneometer is a device that basically treats skin as a non-conductive material and applies electricity with a higher water content. It measures the capacitance at the point where the probe touches. Therefore, the moisture content and the capacitance are proportional to each other, and the higher the measured value, the higher the moisture content. The water content, which is within 30-40 micrometer depth downward from the stratum corneum of the skin, is constantly measured, and the unit is the unit constant, the arbitrary unit (A.U).

In the case of the human body, as the water content becomes smaller, the speed of progress of aging is accelerated. Table 7 shows that when the compositions of Comparative Examples 1 and 2 were used, the moisture content increased before use, but Examples 1 to 7 using the hair restoration composition for alleviating scalp skin of the present invention showed 300-900% The water content of the scalp increased.

When the anti-depressant effect of Test Examples 1 and 2 and the results of preventing, mitigating and preventing the scalp aging are combined, the decline of hair loss, hair thickness and hair density are increased by using the hair loss preventing composition of the present invention. And the scalp aging such as an increase in the elasticity of the hair line is expected to be alleviated and improved.

Claims (6)

Menthol, salicylic acid, adenosine, and dexpanthenol. The anti-depilatory composition according to claim 1, wherein the composition has an effect of alleviating, preventing and preventing scalp aging. The composition of claim 1, wherein the composition is selected from the group consisting of scalp aging comprising 0.05-2 weight percent menthol, 0.05-2 weight percent salicylic acid, 0.01-0.5 weight percent adenosine, and 0.05-15 weight percent dexpanthenol, The anti-depilator composition for relief. The method according to claim 1,
Wherein said composition is selected from the group consisting of retinol, tocopherol, ascorbic acid, collagen, an extract of anthocyanin, an extract of a common myrtle, an extract of an iris, an extract of a thistle flower / leaf / stem, a propolis extract, a marjoram extract, An anti-depilator composition for alleviating scalp aging comprising at least one kind of additional components. The anti-depilatory composition of claim 4, wherein the additional ingredient is present in an amount of 0.01-20% by weight based on the total weight of the composition. A cosmetic product for preventing hair loss, which comprises the composition of claim 1 and is manufactured from a cream, a lotion, an essence, a serum, a toner, a tonic, and a mist.

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