CN101062050A - Novel product for improving hair-growing based on nitric oxide and the preparing method thereof - Google Patents
Novel product for improving hair-growing based on nitric oxide and the preparing method thereof Download PDFInfo
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- CN101062050A CN101062050A CN 200610078011 CN200610078011A CN101062050A CN 101062050 A CN101062050 A CN 101062050A CN 200610078011 CN200610078011 CN 200610078011 CN 200610078011 A CN200610078011 A CN 200610078011A CN 101062050 A CN101062050 A CN 101062050A
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Abstract
The invention discloses a hair tonic appliance and health products, which is characterized by the following: constituting with nitrogen agent and acid agent; choosing the nitrogen from sodium nitrite (sodium nitrite density at 0. 02%-2. 0%) or plant extract of concentrated enriched nitrite; choosing the acid agent from organic acid or inorganic acid; combining the nitrogen agent and the acid agent; discharging effective element nitric oxide; diastolizing capillary blood of brain with nitric oxide; accelerating blood circulation; increasing local blood providing quantity and oxygen delivery. This invention can reach ideal germinal effect.
Description
Technical field:
The present invention relates to a kind of hair growth promoting articles for use and health product, particularly a kind of strong hair growth promoting preparation of sending out, preventing alopecia, hair growth promoting and beauty treatment based on nitric oxide.
Background technology:
Along with human living standard's raising, people more and more pay attention to the external image of oneself.But because now people's work and rhythm of life are accelerated, increasing the weight of and other reason of mental work load causes the phenomenon of alopecia more and more general, and that alopecia has hindered is attractive in appearance, makes many people agonize, even badly influenced some orthobiosis.
Alopecia can be divided into two kinds of temporary alopecia and permanent alopecias basically.Temporary alopecia mostly because have a high fever, malnutrition or dermatosis, the Chronic consumptions of some band inflammation, and endocrine disturbance's a variety of causes reduces the hair follicle blood supply, the temporary malnutrition of perhaps local nerve regulatory function generation obstacle, so that hair follicle and produce the alopecia phenomenon.And that permanent alopecia also can be described as the male is bald, comparatively common, owing to long-time impaired the causing of hair follicle.
The basic reason of alopecia is that hair follicle is impaired, and promptly hair follicle has caused alopecia in varying degrees atrophy, exactly because a wherein common seborrheic alopecia demodicid mite is decomposed a sebum hair follicle is blocked, and can't carry nutrition institute extremely to hair.
According to studies show that: normal scalp's blood flow about 9 times to other position of health, but the bald patient of alopecia, scalp blood flow and normal controls are in a ratio of 13.7: 53.7.
Product for improving hair-growing on the now market mostly just by stimulating blood capillary, increases the hair follicle oxygen-supplying amount, and for hair growth, but the mechanism of hair follicle own well do not improved, and therefore is easy to generate drug dependence.
Since finding that the mammal vascular endothelial cell can synthesize endogenous nitric oxide in 1987, this simple diatomic molecule free radical of nitric oxide just begins to show its infinite charm to common people, is chosen as " star molecule " (Molecule ofthe Year) in 1992 by the U.S. " Science " magazine.After 5 years, U.S. scientist Ignarro, Murad and Fuchgott etc. are owing to the Nobel Prize in medicine of the outstanding work of " nitric oxide is as the signaling molecule of cardiovascular system " being honoured with 1998 years.Their research has disclosed the signal conduction of gas molecule in organism, thereby has evoked global medical circle, biological educational circles and the nitric oxide production research boom of chemical bound pair.
Nitric oxide is a kind of vasodilation composition, can allow blood vessel loosen, and then strengthens blood flow, and blood circulation promoting promptly has the function that increases partial blood circulation and oxygen supply.NO is a kind of very little lipophilic molecule, spread rapidly through the biomembrane barrier by paracrine action, arrive in the contiguous different target cells, and partly link to each other with the ferrohemoglobin of guanylate cyclase in the cell, cause that enzyme activates, the conversion ratio that makes GTP (guanosine triphosphate) be converted into cyclic guanosine monophosphate (cGMP) increases 50-200 doubly, causes intracellular cGMP to increase.CGMP and then activate the GMP deopendent protein kinase or directly act on calcium channel on the cell membrane, cause the calcium ion outflow or quicken the combination of intracellular free calcium, thereby make smooth muscle cell diastole and vasodilation, in this process, cGMP plays a part the second message,second messenger.Simultaneously, but GMP also anticoagulant and platelet in the adhesion on blood vessel endothelium surface.
Because the synthetic nonspecific defense that has participated in several cause of diseases of NO.Macrophages etc. are when activating or can synthesize release NO under some pathological conditions in a large number, cytotoxicity takes place, suppress in the target cell mitochondrion approach such as TCA, electron transport and cell DNA be synthetic antibacterial, fungus and tumor cell are produced lethal effect, promote to organize acute inflammatory reaction, participate in tissue injury and wound healing, thereby cause tissue injury and (or) necrocytosis, kill and wound antibacterial, virus, parasite and tumor cell etc.
Nitric oxide has lethal effect to antibacterial, fungus, parasite, oncocyte.And be a kind of animalcule that colonizes on the scalp as alopecia arch-criminal's a demodicid mite, they colonize in the human hair follicle, are food with the sebum, and secretion separates the fat ferment, corrode sebaceous gland, block hair follicle.Modal is pityrosporum furfur, and fungus a kind of causes one of reason of seborrheic alopecia.
At present, Shang Weijian is based on the report of nitric oxide production hair growth promoting articles for use.
The content of invention:
The purpose of this invention is to provide a kind of diastole that promotes the brain blood capillary by nitric oxide, increase the blood supply oxygen-supplying amount of hair follicle, simultaneously hair follicle is cleared up, repaired, thoroughly improve hair follicle self and surrounding, strengthen the whole upgrowth situation of head hair, and can not produce the strong hair growth promoting preparation of sending out, preventing alopecia, hair growth promoting and beauty treatment of drug dependence.
The present invention realizes with following technical scheme:
The present invention is based on health product and the special defects hair growth promoting articles for use that nitric oxide can improve the hair follicle quality, is made of nitrogen agent and sour agent.
Wherein: the nitrogen agent is a raw material with nitrite or the plant extraction liquid that contains nitrite;
The acid agent is a raw material with organic acid or mineral acid.
When nitrogen agent and sour agent in conjunction with the time, but the just release effective ingredient-nitric oxide of partial controllable system.
Double-formulation hair growth promoting preparation of the present invention and manufacturing process thereof:
Nitrogen agent of the present invention:
The nitrogen agent that the present invention is used for the hair growth promoting articles for use is nitrite or the spissated plant extraction liquid that is rich in nitrite of process, is equipped with corresponding substrate adjuvant and mixes, and emulsifying, sterilization, fill is the product for improving hair-growing of different dosage form, different efficacies.Wherein, the preferred sodium nitrite of nitrite.
Sour agent of the present invention:
The sour agent that the present invention is used for the hair growth promoting articles for use is organic acid, as citric acid monohydrate, maleic acid etc. or mineral acid, as boric acid etc., is equipped with corresponding substrate adjuvant to mix, stir, and sterilization, fill is the hair growth promoting preparation of different dosage form, different efficacies.
Above-mentioned nitrogen agent is identical with the used substrate adjuvant of sour agent with the component that existing product for improving hair-growing uses basically.For example use stearic acid, silicone oil, dimethyl siloxanes etc. are made softening agent, use glycerol, hyaluronic acid, Semen Tritici aestivi germ oil, propylene glycol etc. are made wetting agent, use hexadecanol, octadecanol, glyceryl monostearate, Calcium Disodium Versenate, octadecane oxygen base trimethyl silane (with) stearyl alcohol, aluminum starch succinic acid octene ester etc. is made emulsifying agent, use hydroxyethyl-cellulose, white oil, xanthan gum, castor oil hydrogenated, myristic acid octyldodecanol ester etc. is made thickening agent, use Bronopol, methyl hydroxybenzoate, propylparaben etc. are made antiseptic, use green tea essence etc. is made spice, uses the VE acetas to make antioxidant; Use extracting solution such as Radix Panacis Quinquefolii, Flos Carthami, Herba Menthae to be Chinese medicine extract etc.The consumption of each composition is also identical with existing hair growth promoting articles for use substantially in the substrate.
The host of product of the present invention, substrates quantity scope by weight percentage:
1, nitrogen agent
(1) active component nitrite (sodium nitrite or contain the plant concentrated solution of nitrite) 0.01%～1.0%
(2) hair growth promoting articles for use substrate: 1～90%
(3) surplus is a water;
2, sour agent
(1) one or more in active component ascorbic acid, maleic acid, citric acid monohydrate, the boric acid 0.01%～2.0%
(2) hair growth promoting articles for use substrate: 1～90%
(3) surplus is a water.
Also can contain other hair growth promoting articles for use component commonly used, as: nertralizer, surfactant, wax, sunscreen, vitamins, crease-resistant active component etc.
Usage and dosage:
These hair growth promoting articles for use are divided into two parts, nitrogen agent and sour agent.
Cleaning alopecia place scalp, dry alopecia place scalp after, the nitrogen agent of beans size evenly is applied to alopecia place scalp, sour agent with the beans size evenly is applied to alopecia place scalp again, does slight massage with finger in the alopecia district simultaneously, to increase the infiltration of liquor, promote to absorb, be beneficial to the performance effect.
Application notice:
When using these hair growth promoting articles for use, agent contacts with nitrogen with sour agent, and guarantees that as far as possible sour agent is closely extraneous, the nearly skin of nitrogen agent.This be because:
1, sour agent just can discharge nitric oxide in the part after agent contacts with nitrogen, avoids bacterial infection, reaches antiinflammatory, when improving local skin immunity, alopecia-stopping effect, but again diastole local vascular, mediation hair follicle, promote the growth of hair.
2, because sour agent is closely extraneous, sour agent has reducing power, has reduced the oxidized probability of nitric oxide of new generation.
Storage:
Airtight, put shady and cool dry place and preserve.
The specific embodiment:
Embodiment only is preferred embodiment of the present invention, when not limiting scope of the present invention with this.Generally the equalization of being done according to the present patent application claim changes and modifies, and promptly dissolves in the nitric oxide generation technique in various product for improving hair-growing, and the different prescriptions that make, the product for improving hair-growing of different dosage form all should still belong in the scope that patent of the present invention contains.
Listed embodiment is one of best prescription of product of the present invention, and consumption remembers by weight percentage, wherein the plant extraction liquid of the effective ingredient of nitrogen agent also available Herba Spinaciae extracting solution that contains nitrite etc. except that the act sodium nitrite.
Scheme one: be applicable to beauty treatment, strong sending out
| The N agent | The acid agent | ||
| Composition title (%) | Consumption (%) | Composition title (%) | Consumption (%) |
| Sodium nitrite | 0.04 | Vc | 0.04 |
| EDTA | 0.2 | Salicylic acid | 0.5 |
| Glycerol | 3.0 | Propylene glycol | 0.1 |
| Hydroxyethyl-cellulose | 0.1 | Hydroxyethyl-cellulose | 0.1 |
| Essence | 0.1 | Essence | 0.1 |
| Deionized water | Surplus | Deionized water | Surplus |
Scheme two: at because work, life stress is big, psychentonia and the crowd of a large amount of alopecia:
| The N agent | The acid agent | ||
| Composition title (%) | Consumption (%) | Composition title (%) | Consumption (%) |
| Sodium nitrite | 0.2 | Vc | 0.4 |
| Menthol | 0.2 | Olive oil | 5.0 |
| Capsicum tincture | 0.2 | Glycyrrhizic acid | 0.1 |
| Liquid paraffin | 10.0 | Ethanol | 50.0 |
| Methyl hydroxybenzoate | 0.1 | Methyl hydroxybenzoate | 0.1 |
| Essence | 0.1 | Essence | 0.1 |
| Deionized water | Surplus | Deionized water | Surplus |
Scheme three: be applicable to bald slightly crowd:
| The N agent | The acid agent | ||
| Composition title (%) | Consumption (%) | Composition title (%) | Consumption (%) |
| Sodium nitrite | 0.4 | Vc | 0.8 |
| Biotin | 0.005 | Boric acid | 5.0 |
| D-panthenol | 0.2 | Vitamin E Nicotinate | 0.01 |
| Camphora | 0.1 | Concentrate glycerol | 50.0 |
| Propylparaben | 0.1 | Propylparaben | 0.1 |
| Herba Menthae essence | 0.1 | Herba Menthae essence | 0.1 |
| Deionized water | Surplus | Deionized water | Surplus |
Scheme four: be applicable to chaff baldness (focusing on antiinflammatory):
| The N agent | The acid agent | ||
| Composition title (%) | Consumption (%) | Composition title (%) | Consumption (%) |
| Sodium nitrite | 0.6 | Vc | 1 |
| Minoxidil | 0.005 | The L-cystine | 0.01 |
| Hard paraffin | 3.0 | Allantoin | 0.03 |
| Butoben | 0.1 | Salicylic acid fat silanol | 0.1 |
| C | |||
| Herba Menthae essence | 0.1 | Butoben | 0.1 |
| Deionized water | Surplus | Herba Menthae essence | 0.1 |
| Deionized water | Surplus |
Scheme five: be applicable to the serious crowd's (being commonly called as Mediterranean) of alopecia:
| The N agent | The acid agent | ||
| Composition title (%) | Consumption (%) | Composition title (%) | Consumption (%) |
| Sodium nitrite | 1 | Vc | 1.5 |
| Oleum Vitis viniferae | 3.0 | Maleic acid | 0.6 |
| Ethanol | 2.0 | Liquid paraffin | 10.0 |
| Ethyl hydroxybenzoate | 0.1 | Ethyl hydroxybenzoate | 0.1 |
| Essence | 0.1 | Essence | 0.1 |
| Deionized water | Surplus | Deionized water | Surplus |
Scheme six: be applicable to the alopecia totalis crowd:
| The N agent | The acid agent | ||
| Composition title (%) | Consumption (%) | Composition title (%) | Consumption (%) |
| Sodium nitrite | 2 | Vc | 1.2 |
| The Placenta Hominis hydrosol | 15.0 | Isopropyl alcohol | 21.7 |
| Ethanol | 22.0 | Hydroxyethyl-cellulose | 0.4 |
| Ethyl hydroxybenzoate | 0.1 | Aliphatic alcohol | 50.0 |
| Essence | 0.1 | Ethyl hydroxybenzoate | 0.1 |
| Hydroxyethyl-cellulose | 0.4 | Essence | 0.1 |
| Deionized water | Surplus | Deionized water | Surplus |
Scheme seven: be applicable to the seborrhea symptom
| The N agent | The acid agent | ||
| Composition title (%) | Consumption (%) | Composition title (%) | Consumption (%) |
| Sodium nitrite | 1.8 | Vc | 2.0 |
| Pantothenylol | 0.15 | VB6 | 0.15 |
| The adenosine triphosphate hydrochlorate | 0.01 | Salicylic acid | 0.2 |
| Inositol | 0.1 | Menthol | 0.1 |
| Ethyl hydroxybenzoate | 0.1 | Ethyl hydroxybenzoate | 0.1 |
| Essence | 0.1 | Essence | 0.1 |
| Deionized water | Surplus | Deionized water | Surplus |
The preparation process of listed nitrogen agent of above embodiment and sour agent is: by listed order from top to bottom in the table, each component is added in the entry successively, the mixed stirring dissolved it fully, leaves standstill then and makes the solution becomes clarification, carries out packing under aseptic condition.
Claims (9)
1. based on nitric oxide production novel hair growth promoting articles for use, it is characterized in that: the hair growth promoting articles for use comprise nitrogen agent and sour agent, when nitrogen agent and sour agent combine, and the local nitric oxide that discharges.
2. according to claim 1 based on nitric oxide production novel hair growth promoting articles for use, wherein, the nitrogen agent is nitrite or the plant extraction liquid that is rich in nitrite; The acid agent is organic acid or mineral acid.
3. according to claim 1 based on nitric oxide production novel hair growth promoting articles for use, wherein, the nitrogen agent is a sodium nitrite; The acid agent is one or more in ascorbic acid, citric acid monohydrate, maleic acid, the boric acid.
4. according to claim 2 based on nitric oxide production novel hair growth promoting articles for use, wherein, the plant of being rich in nitrite is Herba Spinaciae, Fructus Solani melongenae.
5. according to claim 1 based on nitric oxide production novel hair growth promoting articles for use, wherein also comprise hair growth promoting articles for use substrate.
6. according to claim 4 based on nitric oxide production novel hair growth promoting articles for use, wherein, hair growth promoting articles for use substrate is one or more in antiseptic, spice, antioxidant, nertralizer, surfactant, the Chinese medicine extract.
7. according to claim 5 based on nitric oxide production novel hair growth promoting articles for use, wherein, hair growth promoting articles for use substrate is stearic acid, silicone oil, dimethyl siloxane, glycerol, hyaluronic acid, Semen Tritici aestivi germ oil, propylene glycol, hexadecanol, octadecanol, glyceryl monostearate, Calcium Disodium Versenate, octadecane oxygen base trimethyl silane and stearyl alcohol, aluminum starch succinic acid octene ester, hydroxyethyl-cellulose, white oil, xanthan gum, castor oil hydrogenated, myristic acid octyldodecanol ester, Bronopol, methyl hydroxybenzoate, propylparaben, green tea essence, Radix Polygoni Multiflori, Radix Ginseng, Radix Angelicae Sinensis, Flos Carthami, Radix Scutellariae, in the extracting solution such as Semen Ginkgo one or more.
8. according to claim 6 based on nitric oxide production novel hair growth promoting articles for use, wherein, each composition weight percentage composition is:
A. nitrogen agent
(1) active component: nitrite 0.02%～2.0%
(2) hair growth promoting articles for use substrate: 1～90%
(3) surplus is a water;
B. sour agent
(1) active component:
In ascorbic acid, maleic acid, citric acid monohydrate, the boric acid one or more 0.5～4%
(2) hair growth promoting articles for use substrate: 1～90%
(3) surplus is a water.
9. according to claim 1 based on nitric oxide production novel hair growth promoting articles for use, usage is for smearing the nitrogen agent earlier, and repaste is smeared sour agent.
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| Application Number | Priority Date | Filing Date | Title |
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| CN 200610078011 CN101062050A (en) | 2006-04-29 | 2006-04-29 | Novel product for improving hair-growing based on nitric oxide and the preparing method thereof |
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| CN 200610078011 CN101062050A (en) | 2006-04-29 | 2006-04-29 | Novel product for improving hair-growing based on nitric oxide and the preparing method thereof |
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Cited By (12)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN105640790A (en) * | 2014-11-28 | 2016-06-08 | 株式会社爱茉莉太平洋 | Hair cosmetic composition comprising maleic acid as active ingredient |
| CN106389457A (en) * | 2016-11-30 | 2017-02-15 | 胡立志 | Medicine for treating alopecia and application of PPAR-gamma agonist to preparation of medicine for treating alopecia |
| CN108096297A (en) * | 2017-10-11 | 2018-06-01 | 河北京鼎生物医药科技有限公司 | Microencapsulation powder and acid microencapsulation powder based on spinach extract, which extend, generates nitric oxide production system and articles for use |
| CN108096296A (en) * | 2017-10-11 | 2018-06-01 | 河北京鼎生物医药科技有限公司 | Microencapsulation powder and acid gel based on spinach extract, which extend, generates nitric oxide production system and articles for use |
| CN108936667A (en) * | 2018-08-29 | 2018-12-07 | 福建千叶百肽生物科技有限公司 | A kind of multi-functional compound fruit and vegetable nitric oxide donors nutrient and preparation method thereof |
| CN109437134A (en) * | 2018-10-26 | 2019-03-08 | 中国核电工程有限公司 | The preparation method and device of nitrogen oxides |
| CN111315348A (en) * | 2017-10-10 | 2020-06-19 | Ucl有限公司 | Cosmetic composition with effects of preventing and relieving scalp aging and preventing alopecia |
| WO2020245573A1 (en) | 2019-06-04 | 2020-12-10 | Thirty Holdings Limited | Methods and compositions for generating nitric oxide and uses thereof |
| WO2020245574A1 (en) | 2019-06-04 | 2020-12-10 | Thirty Respiratory Limited | Methods and compositions for generating nitric oxide and uses thereof to deliver nitric oxide via the respiratory tract |
| WO2021214439A1 (en) | 2020-04-23 | 2021-10-28 | Thirty Respiratory Limited | Methods and compositions for treating and combatting tuberculosis |
| WO2021214440A1 (en) | 2020-04-23 | 2021-10-28 | Thirty Respiratory Limited | Nitric oxide or nitric oxide releasing compositions for use in treating sars-cov and sars-cov-2 |
| CN115400144A (en) * | 2022-09-26 | 2022-11-29 | 杭州泽德医药科技有限公司 | Boric acid and nitrite-containing anti-pathogenic microorganism composition and application thereof |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105640790A (en) * | 2014-11-28 | 2016-06-08 | 株式会社爱茉莉太平洋 | Hair cosmetic composition comprising maleic acid as active ingredient |
| CN105640790B (en) * | 2014-11-28 | 2021-04-13 | 株式会社爱茉莉太平洋 | Cosmetic composition for hair containing maleic acid as active ingredient |
| CN106389457A (en) * | 2016-11-30 | 2017-02-15 | 胡立志 | Medicine for treating alopecia and application of PPAR-gamma agonist to preparation of medicine for treating alopecia |
| CN111315348A (en) * | 2017-10-10 | 2020-06-19 | Ucl有限公司 | Cosmetic composition with effects of preventing and relieving scalp aging and preventing alopecia |
| CN111315348B (en) * | 2017-10-10 | 2023-04-28 | Ucl有限公司 | Cosmetic composition with effects of preventing and relieving scalp aging and preventing alopecia |
| CN108096296A (en) * | 2017-10-11 | 2018-06-01 | 河北京鼎生物医药科技有限公司 | Microencapsulation powder and acid gel based on spinach extract, which extend, generates nitric oxide production system and articles for use |
| CN108096296B (en) * | 2017-10-11 | 2020-10-16 | 河北京鼎生物医药科技有限公司 | System and article for prolonged nitric oxide production based on microencapsulated powders and acidic gels of spinach extracts |
| CN108096297A (en) * | 2017-10-11 | 2018-06-01 | 河北京鼎生物医药科技有限公司 | Microencapsulation powder and acid microencapsulation powder based on spinach extract, which extend, generates nitric oxide production system and articles for use |
| CN108936667A (en) * | 2018-08-29 | 2018-12-07 | 福建千叶百肽生物科技有限公司 | A kind of multi-functional compound fruit and vegetable nitric oxide donors nutrient and preparation method thereof |
| CN109437134A (en) * | 2018-10-26 | 2019-03-08 | 中国核电工程有限公司 | The preparation method and device of nitrogen oxides |
| WO2020245573A1 (en) | 2019-06-04 | 2020-12-10 | Thirty Holdings Limited | Methods and compositions for generating nitric oxide and uses thereof |
| WO2020245574A1 (en) | 2019-06-04 | 2020-12-10 | Thirty Respiratory Limited | Methods and compositions for generating nitric oxide and uses thereof to deliver nitric oxide via the respiratory tract |
| WO2021214439A1 (en) | 2020-04-23 | 2021-10-28 | Thirty Respiratory Limited | Methods and compositions for treating and combatting tuberculosis |
| WO2021214440A1 (en) | 2020-04-23 | 2021-10-28 | Thirty Respiratory Limited | Nitric oxide or nitric oxide releasing compositions for use in treating sars-cov and sars-cov-2 |
| CN115400144A (en) * | 2022-09-26 | 2022-11-29 | 杭州泽德医药科技有限公司 | Boric acid and nitrite-containing anti-pathogenic microorganism composition and application thereof |
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