CN105030601A - Taxus chinensis healthcare toothpaste and preparation method thereof - Google Patents
Taxus chinensis healthcare toothpaste and preparation method thereof Download PDFInfo
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Abstract
The invention relates to taxus chinensis healthcare toothpaste. The taxus chinensis healthcare toothpaste is prepared from, by mass, 1.5-2.5% of taxus chinensis powder, 40-50% of abrasive, 10-30% of excipient, 1-2% of thickener, 0.5-1.5% of essence, 1.5-2.5% of foaming agent, 0.1-0.5% of sweetening agent, 0.1-0.5% of preservative, 0.1-0.2% of humectant, 0.1-0.2% of other additives and the balance deionized water. The invention further relates to a preparation method of the taxus chinensis healthcare toothpaste. As taxol and other beneficial elements in the taxus chinensis powder are utilized, the phagocytic capacity of the mononuclear macrophages of the human body can be improved, so that the immunity of the immune system of the human body is enhanced, the anti-cancer capacity is improved, and the healthcare effect is achieved; the taxus chinensis powder in the toothpaste is scientifically matched with other ingredients, and the toothpaste can effectively avoid dental plaque, dental calculus, periodontitis and other oral inflammation, and can effectively solve the problems of gum bleeding, redness and swelling of the gum and oral malodor.
Description
Technical field
The present invention relates to dental care products, particularly relate to a kind of health taxad toothpaste and preparation method thereof.
Background technology
Toothpaste is used from cleaning teeth with toothbrush one, and protection oral hygiene is a kind of daily necessities of human-body safety.Along with the development of science and technology, present toothpaste is by single clean type toothpaste, develop into the multipurpose tooth paste of great variety of goods, diverse in function, up to a hundred brands, with the needs of satisfied different consumer, if: the patent No. is that " benefit is beneficial late Qing Dynasty fire combination ointment and benefit fire-clearing toothpaste in evening early, and the patent No. is the Chinese invention patent " cold prevention toothpaste " of ZL02135595.9 (Authorization Notice No. is CN1223335C) for the Chinese invention patent of ZL201210005856.9 (Authorization Notice No. is CN102512349B).
Ramulus et folium taxi cuspidatae is one of seeds of the valuable ingredients of traditional Chinese medicine the most of carrying over of 2,500,000 years pre-Quaternary glaciers, and be first-grade state protection rare plant, the paclitaxel extracted from Ramulus et folium taxi cuspidatae is the curing cancer drug that effect is best, the most expensive in the world at present.Ramulus et folium taxi cuspidatae has following effect: (1) cancer preventing and treating: Ramulus et folium taxi cuspidatae contains paclitaxel, it has the effect controlling growth of cancer cells and development, thus strengthen the anti-cancer ability of human body, improve circulation and the metabolic function of human body simultaneously, make to be deposited in virus in human body by urinating, the mode such as defecation is scavenged into external, thus reaches the effect of prophylaxis of cancer, to cancer obtain patient particularly postoperative patient, the side effect of radiotherapy chemotherapy can be reduced, play the effect of auxiliary treatment; (2) body immunity is improved, recover the natural functions of human body: 90 plurality of active ingredients containing needed by human body in Ramulus et folium taxi cuspidatae, the immunity of human body, anti-virus ability can be improved, not only to hyperglycemic patients, there is hypoglycemic effect,, the effect also highly significant such as nephropathy, hepatopathy and dysmenorrhea high to hypertension, hyperlipidemia, blood viscosity, the special urine protein that can reduce runs off, and make human body natural's functional rehabilitation, immunity strengthens; (3) inflammation-diminishing function: containing a large amount of tannins in Ramulus et folium taxi cuspidatae, tannin has antibacterial, antiinflammation, nephritis, hepatitis, gastritis, pharyngolaryngitis, gynecological inflammation, prostatitis, hemorrhoid and rheumatoid etc. is had to the therapeutical effect of highly significant.Ramulus et folium taxi cuspidatae whole body is precious, its leaf, skin, root, branch all contain paclitaxel, in addition also multiple water-soluble flavone is contained in Taxus leaf, as front blue and white element, simultaneously containing catechin, multiple unsaturated fatty acid etc., and the several mineral materials such as rich in proteins and calcium, phosphorus, ferrum in the fruit of Ramulus et folium taxi cuspidatae, and the material such as multivitamin.
Therefore, Ramulus et folium taxi cuspidatae is applied in toothpaste and makes a kind of novel health-care toothpaste, the higher pursuit of people to toothpaste function can be met.
Summary of the invention
First technical problem to be solved by this invention provides a kind of health taxad toothpaste with anti-cancer efficacy.
Second technical problem to be solved by this invention is the preparation method providing the simple above-mentioned health taxad toothpaste of a kind of technique for prior art.
The present invention solves the problems of the technologies described above adopted technical scheme: a kind of health taxad toothpaste, is characterized in that, is made up of the component of following mass percent:
As preferably, described Ramulus et folium taxi cuspidatae powder comprises Taxus leaf powder and bark of Ramulus et folium taxi cuspidatae powder, and the mass ratio of described Taxus leaf powder and bark of Ramulus et folium taxi cuspidatae powder is 2 ~ 3:1, medicinal ingredient in Taxus leaf is higher than other positions of Chinese yew, not only containing abundant cancer-resisting substance---paclitaxel, also containing multiple water-soluble flavone, plant enzyme, Plant fiber, protein, unsaturated fatty acid and multiple-microorganism, and except the same paclitaxel that contains in bark of Ramulus et folium taxi cuspidatae, also containing new taxane, in this outer bark, Plant fiber's content is higher, bark fines to add in toothpaste except playing pharmacological action, the frictional force of toothpaste to dental surface can also be increased by physical action, thus optimize the tooth-cleaning action of toothpaste.
As preferably, described abrasivus is at least one in calcium phosphate dibasic dihydrate, hydrated silica, calcium carbonate, aluminium hydroxide or silicon dioxide;
Adding excipient is in order to can with certain form to form powder toothpaste, and excipient used in the present invention is at least one in xanthan gum, lactose;
Described thickening agent is at least one in sodium carboxymethyl cellulose, hydroxyethyl-cellulose or carrageenan;
Described foaming agent is at least one in sodium lauryl sulphate or sodium lauroyl sarcosine;
Described sweeting agent is at least one in xylitol, saccharin sodium or cyclamate, and above-mentioned sweeting agent can effective caries prevention while improving toothpaste mouthfeel;
Described antiseptic is at least one in methyl hydroxybenzoate or sodium diacetate;
Described wetting agent is mixed with volume ratio 1:1.5 ~ 2.5 by glycerol and sorbitol.
Further, other additives are the one in adjusting agent, sterilization adjuvant or brightening agent, and preferably, described adjusting agent is the one in sodium benzoate or tetrasodium pyrophosphate, described sterilization adjuvant is the one in trichlorophenol, Olibanum oil or propolis extract, and described brightening agent is hydroxyapatite.
The present invention solves the technical scheme that second technical problem adopt: the preparation method of above-mentioned health taxad toothpaste comprises the following steps:
(1) Ramulus et folium taxi cuspidatae powder preparation: get Taxus leaf and bark of Ramulus et folium taxi cuspidatae respectively, crushed after being dried, sieve particle diameter be 200 ~ 300 object Taxus leaf powder and particle diameter is 100 ~ 150 object bark of Ramulus et folium taxi cuspidatae powder respectively, Taxus leaf powder and bark of Ramulus et folium taxi cuspidatae powder are that 2 ~ 3:1 mix homogeneously obtains Ramulus et folium taxi cuspidatae powder with mass ratio;
(2) obtained Ramulus et folium taxi cuspidatae powder, wetting agent and antiseptic mixed by above-mentioned mass percent and add deionized water and stirring and evenly make aqueous solution, then abrasivus, excipient, foaming agent and other additives is added by above-mentioned mass percent to aqueous solution, send in vacuum Manufacturing medicine extract machine after mix homogeneously, high-speed stirred grinding 30 ~ 45min, vacuum outgas, then essence and sweeting agent is added, high-speed stirred grinding 10 ~ 15min again, obtain lotion of toothpaste, after sterile filling, packaging, obtain health taxad toothpaste.
As preferably, described abrasivus is calcium phosphate dibasic dihydrate, hydrated silica, calcium carbonate, at least one in aluminium hydroxide or silicon dioxide, described excipient is the one in xanthan gum or lactose, described thickening agent is sodium carboxymethyl cellulose, at least one in hydroxyethyl-cellulose or carrageenan, described foaming agent is at least one in sodium lauryl sulphate or sodium lauroyl sarcosine, described sweeting agent is xylitol, at least one in saccharin sodium or cyclamate, described antiseptic is at least one in methyl hydroxybenzoate or sodium diacetate, described wetting agent is mixed with volume ratio 1:1.5 ~ 2.5 by glycerol and sorbitol.
As preferably, other additives described are the one in adjusting agent, sterilization adjuvant or brightening agent, wherein said adjusting agent is the one in sodium benzoate or tetrasodium pyrophosphate, and described sterilization adjuvant is the one in trichlorophenol, Olibanum oil or propolis extract, and described brightening agent is hydroxyapatite.
Compared with prior art, the invention has the advantages that: in the health taxad toothpaste in the present invention, add Ramulus et folium taxi cuspidatae powder, utilize the multiple beneficial composition such as paclitaxel in Ramulus et folium taxi cuspidatae powder, human monocytic's macrophages phagocytic capacity can be increased, thus strengthen the immunity of human immune system, improve cancer-resisting ability, reach health-care effect; In addition, Ramulus et folium taxi cuspidatae powder and other composition science assembly in this toothpaste, effectively can avoid occurring without oral inflammations such as the generation of dental plaque and dental calculus and periodontitis, effectively can improve gingival hemorrhage, red swelling of gingiva and halitosis problem.
Detailed description of the invention
Below in conjunction with embodiment, the present invention is described in further detail.
Embodiment 1:
Health taxad toothpaste is made up of the component of following mass percent:
Preparation process is as follows:
(1) Ramulus et folium taxi cuspidatae powder preparation: get Taxus leaf and bark of Ramulus et folium taxi cuspidatae, crushed after being dried, sieve particle diameter be 200 object Taxus leaf powder and particle diameter is 100 object bark of Ramulus et folium taxi cuspidatae powder respectively, Taxus leaf powder and bark of Ramulus et folium taxi cuspidatae powder are that 2:1 mix homogeneously obtains Ramulus et folium taxi cuspidatae powder with mass ratio;
(2) obtained Ramulus et folium taxi cuspidatae powder, glycerol and sorbitol mixture and methyl hydroxybenzoate mixed by above-mentioned mass percent and add deionized water and stirring and evenly make aqueous solution, then calcium carbonate, xanthan gum, sodium lauryl sulphate and tetrasodium pyrophosphate is added by above-mentioned mass percent to aqueous solution, send in vacuum Manufacturing medicine extract machine after mix homogeneously, high-speed stirred grinding 30min, vacuum outgas, then essence and sweeting agent is added, high-speed stirred grinding 10min again, obtain lotion of toothpaste, after sterile filling, packaging, obtain health taxad toothpaste.
Embodiment 2:
Health taxad toothpaste is made up of the component of following mass percent:
Preparation process is as follows:
(1) Ramulus et folium taxi cuspidatae powder preparation: get Taxus leaf and bark of Ramulus et folium taxi cuspidatae, crushed after being dried, sieve particle diameter be 300 object Taxus leaf powder and particle diameter is 150 object bark of Ramulus et folium taxi cuspidatae powder respectively, Taxus leaf powder and bark of Ramulus et folium taxi cuspidatae powder are that 3:1 mix homogeneously obtains Ramulus et folium taxi cuspidatae powder with mass ratio;
(2) obtained Ramulus et folium taxi cuspidatae powder, wetting agent and antiseptic mixed by above-mentioned mass percent and add deionized water and stirring and evenly make aqueous solution, then abrasivus, excipient, foaming agent and other additives is added by above-mentioned mass percent to aqueous solution, send in vacuum Manufacturing medicine extract machine after mix homogeneously, high-speed stirred grinding 45min, vacuum outgas, then essence and sweeting agent is added, high-speed stirred grinding 15min again, obtain lotion of toothpaste, after sterile filling, packaging, obtain health taxad toothpaste.
Embodiment 3:
Health taxad toothpaste is made up of the component of following mass percent:
Preparation process is as follows:
(1) Ramulus et folium taxi cuspidatae powder preparation: get Taxus leaf and bark of Ramulus et folium taxi cuspidatae, crushed after being dried, sieve particle diameter be 250 object Taxus leaf powder and particle diameter is 120 object bark of Ramulus et folium taxi cuspidatae powder respectively, Taxus leaf powder and bark of Ramulus et folium taxi cuspidatae powder are that 2.5:1 mix homogeneously obtains Ramulus et folium taxi cuspidatae powder with mass ratio;
(2) obtained Ramulus et folium taxi cuspidatae powder, wetting agent and antiseptic mixed by above-mentioned mass percent and add deionized water and stirring and evenly make aqueous solution, then abrasivus, excipient, foaming agent and other additives is added by above-mentioned mass percent to aqueous solution, send in vacuum Manufacturing medicine extract machine after mix homogeneously, high-speed stirred grinding 37min, vacuum outgas, then essence and sweeting agent is added, high-speed stirred grinding 12min again, obtain lotion of toothpaste, after sterile filling, packaging, obtain health taxad toothpaste.
Embodiment 4:
Health taxad toothpaste is made up of the component of following mass percent:
Preparation process is as follows:
(1) Ramulus et folium taxi cuspidatae powder preparation: get Taxus leaf and bark of Ramulus et folium taxi cuspidatae, crushed after being dried, sieve particle diameter be 280 object Taxus leaf powder and particle diameter is 120 object bark of Ramulus et folium taxi cuspidatae powder respectively, Taxus leaf powder and bark of Ramulus et folium taxi cuspidatae powder are that 2.8:1 mix homogeneously obtains Ramulus et folium taxi cuspidatae powder with mass ratio;
(2) obtained Ramulus et folium taxi cuspidatae powder, wetting agent and antiseptic mixed by above-mentioned mass percent and add deionized water and stirring and evenly make aqueous solution, then abrasivus, excipient, foaming agent and other additives is added by above-mentioned mass percent to aqueous solution, send in vacuum Manufacturing medicine extract machine after mix homogeneously, high-speed stirred grinding 42min, vacuum outgas, then essence and sweeting agent is added, high-speed stirred grinding 15min again, obtain lotion of toothpaste, after sterile filling, packaging, obtain health taxad toothpaste.
Embodiment 5:
Health taxad toothpaste is made up of the component of following mass percent:
Preparation process is as follows:
(1) Ramulus et folium taxi cuspidatae powder preparation: get Taxus leaf and bark of Ramulus et folium taxi cuspidatae, crushed after being dried, sieve particle diameter be 300 object Taxus leaf powder and particle diameter is 150 object bark of Ramulus et folium taxi cuspidatae powder respectively, Taxus leaf powder and bark of Ramulus et folium taxi cuspidatae powder are that 2:1 mix homogeneously obtains Ramulus et folium taxi cuspidatae powder with mass ratio;
(2) obtained Ramulus et folium taxi cuspidatae powder, wetting agent and antiseptic mixed by above-mentioned mass percent and add deionized water and stirring and evenly make aqueous solution, then abrasivus, excipient, foaming agent and other additives is added by above-mentioned mass percent to aqueous solution, send in vacuum Manufacturing medicine extract machine after mix homogeneously, high-speed stirred grinding 40min, vacuum outgas, then essence and sweeting agent is added, high-speed stirred grinding 10min again, obtain lotion of toothpaste, after sterile filling, packaging, obtain health taxad toothpaste.
Comparative example:
Toothpaste in comparative example is made up of the component of following mass percent:
Preparation process is as follows:
Wetting agent and antiseptic are mixed by above-mentioned mass percent and adds deionized water and stirring and evenly make aqueous solution, then abrasivus, excipient, foaming agent and other additives is added by above-mentioned mass percent to aqueous solution, send in vacuum Manufacturing medicine extract machine after mix homogeneously, high-speed stirred grinding 45min, vacuum outgas, then adds essence and sweeting agent, then high-speed stirred grinding 15min, obtain lotion of toothpaste, after sterile filling, packaging, obtain the toothpaste in comparative example.
Experimenter 60 people choosing outpatient service health tests, the each half of men and women, subject age span is 40 ~ 60 years old, 48 years old mean age, be divided into six groups at random, be respectively matched group and test group 1,2,3,4,5, wherein test group 1 ~ 5 uses the health taxad toothpaste of preparation in embodiment 1 ~ 5 (adding Ramulus et folium taxi cuspidatae powder) respectively, and matched group uses the toothpaste (not adding Ramulus et folium taxi cuspidatae powder) prepared in comparative example.In process of the test, experimenter respectively brushes teeth once sooner or later.
Test after one month, get experimenter's blood sample, separating periphery blood monocytic cell, gives recombinant humangranulocyte---M-CSF (GM-CSF), turn out mononuclear phagocyte, the phagocytic activity of mononuclear phagocyte is detected by Flow Cytometry and confocal microscopy, result is as shown in table 1, and from table 1, health taxad toothpaste can strengthen mononuclear phagocyte phagocytic activity, thus strengthen the immunity of human immune system, improve cancer-resisting ability.In addition, compared with matched group, after the experimenter of test group uses the health taxad toothpaste in the present invention, breath freshening, tooth brilliant white, without the generation of the oral inflammation such as generation and periodontitis of dental plaque and dental calculus, effectively can improve gingival hemorrhage, red swelling of gingiva and halitosis problem.
Table 1 health taxad toothpaste is on the impact of experimenter's mononuclear phagocyte phagocytic activity
| Group | Number of subjects | Grazing rate (K) | Phagocytic index (α) |
| Matched group | 10 | 0.028±0.011 | 3.56±0.59 |
| Test group 1 | 10 | 0.028±0.015 | 3.89±0.52 |
| Test group 2 | 10 | 0.044±0.034 | 4.65±1.02 |
| Test group 3 | 10 | 0.036±0.009 | 4.70±1.09 |
| Test group 4 | 10 | 0.033±0.041 | 4.23±0.89 |
| Test group 5 | 10 | 0.037±0.018 | 4.56±0.67 |
Claims (9)
1. a health taxad toothpaste, is characterized in that, is made up of the component of following mass percent:
2. health taxad toothpaste as claimed in claim 1, it is characterized in that, described Ramulus et folium taxi cuspidatae powder comprises Taxus leaf powder and bark of Ramulus et folium taxi cuspidatae powder, and the mass ratio of described Taxus leaf powder and bark of Ramulus et folium taxi cuspidatae powder is 2 ~ 3:1.
3. health taxad toothpaste as claimed in claim 2, it is characterized in that, the particle diameter of described Taxus leaf powder is 200 ~ 300 orders, and the particle diameter of described bark of Ramulus et folium taxi cuspidatae powder is 100 ~ 150 orders.
4. the health taxad toothpaste as described in claim 1 or 2 or 3, it is characterized in that, described abrasivus is calcium phosphate dibasic dihydrate, hydrated silica, calcium carbonate, at least one in aluminium hydroxide or silicon dioxide, described excipient is the one in xanthan gum or lactose, described thickening agent is sodium carboxymethyl cellulose, at least one in hydroxyethyl-cellulose or carrageenan, described foaming agent is at least one in sodium lauryl sulphate or sodium lauroyl sarcosine, described sweeting agent is xylitol, at least one in saccharin sodium or cyclamate, described antiseptic is at least one in methyl hydroxybenzoate or sodium diacetate, described wetting agent is mixed with volume ratio 1:1.5 ~ 2.5 by glycerol and sorbitol.
5. health taxad toothpaste as claimed in claim 4, is characterized in that, other additives described are the one in adjusting agent, sterilization adjuvant or brightening agent.
6. health taxad toothpaste as claimed in claim 5, is characterized in that, described adjusting agent is the one in sodium benzoate or tetrasodium pyrophosphate, and described sterilization adjuvant is the one in trichlorophenol, Olibanum oil or propolis extract, and described brightening agent is hydroxyapatite.
7. a preparation method for health taxad toothpaste as claimed in claim 1, is characterized in that comprising the following steps:
(1) Ramulus et folium taxi cuspidatae powder preparation: get Taxus leaf and bark of Ramulus et folium taxi cuspidatae respectively, crushed after being dried, sieve particle diameter be 200 ~ 300 object Taxus leaf powder and particle diameter is 100 ~ 150 object bark of Ramulus et folium taxi cuspidatae powder respectively, Taxus leaf powder and bark of Ramulus et folium taxi cuspidatae powder are that 2 ~ 3:1 mix homogeneously obtains Ramulus et folium taxi cuspidatae powder with mass ratio;
(2) obtained Ramulus et folium taxi cuspidatae powder, wetting agent and antiseptic mixed by above-mentioned mass percent and add deionized water and stirring and evenly make aqueous solution, then abrasivus, excipient, foaming agent and other additives is added by above-mentioned mass percent to aqueous solution, send in vacuum Manufacturing medicine extract machine after mix homogeneously, high-speed stirred grinding 30 ~ 45min, vacuum outgas, then essence and sweeting agent is added, high-speed stirred grinding 10 ~ 15min again, obtain lotion of toothpaste, after sterile filling, packaging, obtain health taxad toothpaste.
8. the preparation method of health taxad toothpaste as claimed in claim 7, it is characterized in that, described abrasivus is calcium phosphate dibasic dihydrate, hydrated silica, calcium carbonate, at least one in aluminium hydroxide or silicon dioxide, described excipient is xanthan gum, at least one in lactose, described thickening agent is sodium carboxymethyl cellulose, at least one in hydroxyethyl-cellulose or carrageenan, described foaming agent is at least one in sodium lauryl sulphate or sodium lauroyl sarcosine, described sweeting agent is xylitol, at least one in saccharin sodium or sorbitol, described antiseptic is at least one in methyl hydroxybenzoate or sodium diacetate, described wetting agent is mixed with volume ratio 1:1.5 ~ 2.5 by glycerol and sorbitol.
9. the preparation method of health taxad toothpaste as claimed in claim 8, it is characterized in that, other additives described are the one in adjusting agent, sterilization adjuvant or brightening agent, wherein said adjusting agent is the one in sodium benzoate or tetrasodium pyrophosphate, described sterilization adjuvant is at least one in trichlorophenol, Olibanum oil or propolis extract, and described brightening agent is hydroxyapatite.
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| CN105853274A (en) * | 2016-04-18 | 2016-08-17 | 李红霞 | Toothpaste containing chelidonium majus extract |
| CN106667800A (en) * | 2016-08-25 | 2017-05-17 | 江玉成 | Taxus chinensis toothpaste and preparation method thereof |
| CN107028829A (en) * | 2017-04-25 | 2017-08-11 | 攀枝花学院 | Compound mango leaf extract anti-inflammatory health toothpaste and preparation method thereof |
| CN108464963A (en) * | 2018-04-12 | 2018-08-31 | 弘美制药（中国）有限公司 | It is a kind of for the composition in oral cavity and its application and preparation method |
| CN109431857A (en) * | 2019-01-02 | 2019-03-08 | 华熙福瑞达生物医药有限公司 | A kind of toothpaste and preparation method thereof containing hyaluronic acid |
| CN110859779A (en) * | 2019-11-29 | 2020-03-06 | 重庆登康口腔护理用品股份有限公司 | Oral care product containing plant fiber abrasive and preparation method thereof |
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| CN101919795A (en) * | 2009-06-12 | 2010-12-22 | 粟时献 | Nano-taxaceae series health care daily necessities and manufacturing method thereof |
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Cited By (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105853274A (en) * | 2016-04-18 | 2016-08-17 | 李红霞 | Toothpaste containing chelidonium majus extract |
| CN106667800A (en) * | 2016-08-25 | 2017-05-17 | 江玉成 | Taxus chinensis toothpaste and preparation method thereof |
| CN107028829A (en) * | 2017-04-25 | 2017-08-11 | 攀枝花学院 | Compound mango leaf extract anti-inflammatory health toothpaste and preparation method thereof |
| CN107028829B (en) * | 2017-04-25 | 2020-07-21 | 攀枝花学院 | Compound mango leaf extract anti-inflammatory health-care toothpaste and preparation method thereof |
| CN108464963A (en) * | 2018-04-12 | 2018-08-31 | 弘美制药（中国）有限公司 | It is a kind of for the composition in oral cavity and its application and preparation method |
| CN108464963B (en) * | 2018-04-12 | 2020-06-16 | 弘美制药（中国）有限公司 | Composition for oral cavity and application and preparation method thereof |
| CN109431857A (en) * | 2019-01-02 | 2019-03-08 | 华熙福瑞达生物医药有限公司 | A kind of toothpaste and preparation method thereof containing hyaluronic acid |
| CN109431857B (en) * | 2019-01-02 | 2021-10-01 | 华熙生物科技股份有限公司 | Toothpaste containing hyaluronic acid and preparation method thereof |
| CN110859779A (en) * | 2019-11-29 | 2020-03-06 | 重庆登康口腔护理用品股份有限公司 | Oral care product containing plant fiber abrasive and preparation method thereof |
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