CN109431857A - A kind of toothpaste and preparation method thereof containing hyaluronic acid - Google Patents
A kind of toothpaste and preparation method thereof containing hyaluronic acid Download PDFInfo
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- CN109431857A CN109431857A CN201910001282.XA CN201910001282A CN109431857A CN 109431857 A CN109431857 A CN 109431857A CN 201910001282 A CN201910001282 A CN 201910001282A CN 109431857 A CN109431857 A CN 109431857A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
- A61K8/735—Mucopolysaccharides, e.g. hyaluronic acid; Derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
- A61K8/25—Silicon; Compounds thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
- A61K8/26—Aluminium; Compounds thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
- A61K8/345—Alcohols containing more than one hydroxy group
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/48—Thickener, Thickening system
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Abstract
A kind of toothpaste containing hyaluronic acid is disclosed, hyaluronic acid, rubbing agent, foaming agent, sweetener, preservative, essence, the D-sorbite, deionized water for being 500KDa-1500KDa comprising molecular weight.Toothpaste of the present invention containing hyaluronic acid so that the wetting of toothpaste mouthfeel, moisture retention and stability are strong, and can substantially reduce the content of D-sorbite, increase the safety of toothpaste using polymer hyaluronic acid as thickener and moisturizer.
Description
Technical field
This application involves oral care implement fields, and relate more particularly to a kind of toothpaste and its system containing hyaluronic acid
Preparation Method.
Background technique
Toothpaste is a kind of mixed system of complexity, therefore to guarantee that a kind of uniform, dispersion, the good cream of appearance is made in toothpaste
Shape object, and keep relative stability within a certain period of time, there is certain difficulty.Thickener and moisturizer in toothpaste is to lotion
It is most important for stability.
Toothpaste belongs to solid phase dispersion in one of liquid phase suspended substance, there is very big boundary between decentralized medium and dispersed phase
Face energy, the aggregation sedimentation of dispersed particle, needs to be added thickening binder in order to prevent, they disperse, swell in toothpaste liquid phase, change
The rheological characteristic and viscosity of kind toothpaste, form stable colloid is prevented toothpaste Solid-Liquid Separation, but is not produced with the toothpaste solid phase that suspends
Raw " wire drawing " phenomenon, to be readily produced, filling and use.Existing frequently-used thickening binder have carboxymethyl cellulose (CMC),
Methylcellulose MC, hydroxyethyl cellulose, xanthan gum etc..However they are non-natural prods, there is certain secondary work to human body
With.
When toothpaste is exposed to air, the moisture in lotion will evaporate, and toothpaste is gradually dry and hard and is difficult to squeeze out and use,
After the moisturizer such as glycerol, D-sorbite are added, due to their hygroscopicity, the evaporation of moisture is slowed down, lotion is made to keep paste.
Glycerol frost resistance is poor, and if the paste stability of only making moisturizer with D-sorbite is poor, be required to other moisturizer or
Thickener compounding.
Hyaluronic acid is glued by the macromolecular acidity that D-Glucose aldehydic acid and N-acetylglucosamine dissacharide units form
Polysaccharide, is called sodium hyaluronate, and Columbia Univ USA's ophthalmology professor Meyer in 1934 etc. is isolated from bovine vitreous body first
The substance.Hyaluronic acid shows a variety of important physiological functions with its unique molecular structure and physicochemical property in body,
Such as lubricating joint, the permeability of vascular wall, regulatory protein matter, Water-Electrolyte diffusion and operating are adjusted, wound healing etc. is promoted.Especially
For importantly, hyaluronic acid is the substance that moisture retention is best in presently found nature, quilt with special water retention
Referred to as ideal natural moisturizing factor (Natural moisturizing factor, NMF, such as: 2% pure hyaluronic acid water
Solution can firmly hold 98% moisture).
Hyaluronic acid has been used in oral care product at present, as patent CN104666112B discloses D-sorbite pair
Hyaluronic acid activity acts synergistically with good synergy, but the amount of D-sorbite is up to 30-70%, and research shows that mistake
The D-sorbite of amount can cause diarrhea and digestive disorders, and the people of the content D-sorbite toothpaste is used for a long time, and health will receive sternly
The influence of weight, is harmful to the human body.
Summary of the invention
In order to solve the above-mentioned technical problem, the application is proposed.Embodiments herein provides a kind of containing hyaluronic acid
Toothpaste and preparation method thereof, which has good Water-saving effect, and can substantially reduce sorb
The usage amount of sugar alcohol.
To achieve the above object, the present invention adopts the following technical scheme that.
1, a kind of toothpaste containing hyaluronic acid, which is characterized in that the hyalomitome for being 500KDa-1500KDa comprising molecular weight
Acid, rubbing agent, foaming agent, sweetener, preservative, essence, D-sorbite, deionized water.
2, containing the toothpaste of hyaluronic acid according to item 1, which is characterized in that the molecular weight of the hyaluronic acid is
800KDa-1200KDa。
3, containing the toothpaste of hyaluronic acid according to item 1, which is characterized in that the group relative to 100 parts by weight of total weight
Object is closed, the content of the hyaluronic acid is 0.1-10 parts by weight；The content of the D-sorbite is 1-5 parts by weight.
4, containing the toothpaste of hyaluronic acid according to item 3, which is characterized in that the group relative to 100 parts by weight of total weight
Object is closed, the content of the hyaluronic acid is 0.1-1 parts by weight；The content of the D-sorbite is 2 parts by weight.
5, containing the toothpaste of hyaluronic acid according to item 1, which is characterized in that the group relative to 100 parts by weight of total weight
Close object, the content of the rubbing agent is 10-25 parts by weight, and the rubbing agent be selected from aluminium hydroxide, silica, calcium carbonate with
And at least one of calcium bicarbonate.
6, containing the toothpaste of hyaluronic acid according to item 1, which is characterized in that the group relative to 100 parts by weight of total weight
It closes object, the 1.5-2.5 parts by weight of the foaming agent, and the foaming agent and is selected from sldium lauryl sulfate, lauryl sodium sulfate, N-
At least one of sodium lauroyl sarcosine.
7, containing the toothpaste of hyaluronic acid according to item 1, which is characterized in that the group relative to 100 parts by weight of total weight
Object is closed, the content of the sweetener is 0.1-0.5 parts by weight, and the sweetener is selected from saccharin sodium, maltitol, cyclohexylamine sulphur
Sour sodium is at least one.
8, containing the toothpaste of hyaluronic acid according to item 1, which is characterized in that the group relative to 100 parts by weight of total weight
Close object, the content of the preservative is 0.1-0.5 parts by weight, and the preservative in potassium sorbate, sodium benzoate extremely
Few one kind.
9, containing the toothpaste of hyaluronic acid according to item 1, which is characterized in that the group relative to 100 parts by weight of total weight
Object is closed, the content of the essence is 0.5-1.5 parts by weight, and the essence is selected from least one of peppermint oil, wintergreen.
10, a kind of preparation method of the toothpaste containing hyaluronic acid, the preparation method are characterised by comprising following steps:
The hyaluronic acid, D-sorbite and sweetener of 500KDa-1500KDa are added in deionized water and obtain the first mixing
Solution；
Foaming agent is added in rubbing agent and obtains mixed-powder；
The mixed-powder is added in first mixed solution and obtains lotion；
Heating water bath in essence is added in preservative, obtains the second mixed solution；
Second mixed solution is added in the lotion, vacuum suction, obtains the toothpaste containing hyaluronic acid.
11, the preparation method of the toothpaste according to item 10 containing hyaluronic acid, which is characterized in that the hyaluronic acid
Molecular weight is 800KDa-1200KDa.
12, the preparation method of the toothpaste according to item 10 containing hyaluronic acid, which is characterized in that relative to total weight
The composition of 100 parts by weight, the content of the hyaluronic acid are 0.1-10 parts by weight；The content of the D-sorbite is 1-5 weight
Measure part.
13, the preparation method of the toothpaste according to item 12 containing hyaluronic acid, which is characterized in that relative to total weight
The composition of 100 parts by weight, the content of the hyaluronic acid are 0.1-1 parts by weight；The content of the D-sorbite is 1-2 weight
Part.
14, the preparation method of the toothpaste according to item 10 containing hyaluronic acid, which is characterized in that relative to total weight
The composition of 100 parts by weight, the content of the rubbing agent is 10-25 parts by weight, and the rubbing agent is selected from aluminium hydroxide, dioxy
At least one of SiClx, calcium carbonate and calcium bicarbonate.
15, the preparation method of the toothpaste according to item 10 containing hyaluronic acid, which is characterized in that relative to total weight
The composition of 100 parts by weight, the content of the foaming agent is 1.5-2.5 parts by weight, and the foaming agent is selected from laruyl alcohol sulfuric acid
At least one of sodium, lauryl sodium sulfate, N- sodium lauroyl sarcosine.
16, the preparation method of the toothpaste according to item 10 containing hyaluronic acid, which is characterized in that relative to total weight
The composition of 100 parts by weight, the content of the sweetener is 0.1-0.5 parts by weight, and the sweetener is selected from saccharin sodium, malt
Sugar alcohol, cyclohexylamine sulfonic acid sodium are at least one.
17, the preparation method of the toothpaste according to item 10 containing hyaluronic acid, which is characterized in that relative to total weight
The composition of 100 parts by weight, the content of the preservative is 0.1-0.5 parts by weight, and the preservative is selected from potassium sorbate, benzene
At least one of sodium formate.
18, the preparation method of the toothpaste according to item 10 containing hyaluronic acid, which is characterized in that relative to total weight
The content of the composition of 100 parts by weight, the essence is 0.5-1.5 parts by weight, and the essence is in peppermint oil, wintergreen
At least one.
Toothpaste of the present invention containing hyaluronic acid is made using polymer hyaluronic acid as thickener and moisturizer
It is strong to obtain the wetting of toothpaste mouthfeel, moisture retention and stability, and the content of D-sorbite can be substantially reduced, increases the peace of toothpaste
Quan Xing.
The specific embodiment of invention
Toothpaste provided by the invention containing hyaluronic acid, comprising molecular weight be 500KDa-1500KDa hyaluronic acid, rub
Liniment, foaming agent, sweetener, preservative, essence, D-sorbite, deionized water.Combination relative to 100 parts by weight of total weight
Object, the content of the hyaluronic acid are 0.1-10 parts by weight；The content of the D-sorbite is 1-5 parts by weight.
For hyaluronic acid universally present in biological cell interstitial, no species difference and immunogenicity are safe and non-toxic,
With fine biocompatibility.Polymer hyaluronic acid aqueous solution is in gel, and aqueous solution has preferable moisture retention, and (1g is saturating
Bright matter acid can keep the moisture of 1000g), also having good viscoelasticity, (dynamic viscosity of 1% hyaluronic acid solution is reachable
10000~50000mPas), thixotropy and pseudoplastic behavior, toothpaste moisturizer, thickener can be used as to use simultaneously, so that the tooth
Cream taste lubrication, moisture retention are strong and compatibility is strong, but also lotion of toothpaste drying can be prevented to be hardened.
The content in the present invention being more preferably the hyaluronic acid is 0.1-1 parts by weight；The D-sorbite contains
Amount is 1-2 parts by weight, and the molecular weight of hyaluronic acid can be more preferably 800KDa-1200KDa, using the transparent of the molecular weight
Toothpaste made of matter acid, water-retaining property is best, and the dosage of D-sorbite is less, and D-sorbite has a moisture absorption, water retention, still
Excessive D-sorbite can cause diarrhea and digestive disorders, and health will receive serious influence, therefore the application greatly reduces
The content of D-sorbite, securely and reliably.
Rubbing agent is not particularly limited in the present invention, relative to the composition of 100 parts by weight of total weight, the rubbing agent
Content is 10-25 parts by weight, preferably at least one of aluminium hydroxide, silica, calcium carbonate and calcium bicarbonate.Tradition
Abrasive be all calcium containing compound, such as calcium monohydrogen phosphate, calcium carbonate, due to similar to sclerous tissues' ingredient of tooth, also recognized
To play the role of supplementing dental tissue defect.After nineteen sixty, there is non-calcium compound as abrasive, such as precipitated silica
Silicon, aluminium hydroxide etc., the rubbing agent are mainly the tartar for wiping dental surface, and it is external to mitigate tooth stain, plaque, calculus dentalis etc.
Substance.
Foaming agent is not particularly limited in the present invention, relative to the composition of 100 parts by weight of total weight, the foaming agent
At least one of 1.5-2.5 parts by weight, preferably sldium lauryl sulfate, lauryl sodium sulfate, N- sodium lauroyl sarcosine.
Foaming agent (also known as surfactant) be can reduce in toothpaste surface tension of liquid, have it is good wetting, foaming, emulsification,
The material composition of detergent action；Foaming agent is one of integral component of toothpaste.Its emulsification facilitates the oil-solubles object such as essence
Other components in matter and lotion are uniformly combined into stable system.The abundant foam generated when brushing teeth, can suspend tartar etc.,
Removing is flush with water when gargling, to achieve the purpose that remove tartar, cleaning oral cavity.
Sweetener is not particularly limited in the present invention, relative to the composition of 100 parts by weight of total weight, the sweetener
Content is 0.1-0.5 parts by weight, and preferably saccharin sodium, maltitol, cyclohexylamine sulfonic acid sodium are at least one.Sweetener type compared with
It is more, natural sweetener and artificial synthesis edulcorant can be divided by its source；It is divided into nutritive sweetener and non-by its nutritive value
Nutritive sweetener；It is divided into carbohydrate and non-sugar sweetener by its chemical structure and property.Sweet taste is sweetener molecule pungent taste
Physics, chemistry and the physiology course for a kind of complexity that flower bud generates.The height of sweet taste is known as sugariness, is the important indicator of sweetener.
Sugariness cannot use the method quantitative determination of physics, chemistry, can only carry out sense organ judgement by the sense of taste of people, the sweet taste in toothpaste
Agent is primarily used to cover the bad taste that other compositions generate, so that toothpaste is good in taste.
Preservative is not particularly limited in the present invention, relative to the composition of 100 parts by weight of total weight, the preservative
Content is 0.1-0.5 parts by weight, preferably at least one of potassium sorbate, sodium benzoate.Toothpaste is in production, conveying, storage
During be easy to can pollution due to the factors such as ambient enviroment, raw material by microorganism, in addition the carbon hydrate in toothpaste
Object, carbohydrate, alcohols etc. can provide energy and nutriment for growth, the breeding of microorganism, therefore, it is difficult to meet national standard
To the control of toothpaste microorganism requirement, so add preservative in toothpaste, the preservative in toothpaste can not only inhibit bacterium,
The metabolism of mould and saccharomycete, but also its growth can be inhibited, therefore the toothpaste after addition preservative is more pacified
Entirely.
Essence is not particularly limited in the present invention, relative to the composition of 100 parts by weight of total weight, the content of the essence
For 0.5-1.5 parts by weight, preferably at least one of peppermint oil, wintergreen.The toothpaste perfume (or spice) that essence is referring to natural plants
Taste is deployed using natural perfume material and synthetic perfume, the material composition with natural flavour mountaineous and various odor type.Toothpaste essence
The fragrance of the certain type of toothpaste is not only assigned, and to assign the taste of certain type, making consumer, oral cavity is felt when in use
It is comfortable to happiness, while refrigerant frankness.And certain ingredients in toothpaste have special aroma and flavor, and essence can be hidden
These peculiar smell allow consumer giocoso to receive and use.In addition certain flavouring ingredients in essence have bacteriostasis efficacy, in hundred
Fragrant phenol, eugenol, peppermint oil etc. have certain auxiliary curative effect to mouth diseases such as periodontosis, halitosis.
The preparation method of toothpaste provided by the present invention containing hyaluronic acid, includes the following steps:
Step 1: the hyaluronic acid, D-sorbite and sweetener of 500KDa-1500KDa is added in deionized water and obtains the
One mixed solution；
Step 2, foaming agent is added in rubbing agent and obtains mixed-powder；
Step 3, the mixed-powder is added in first mixed solution and obtains lotion；
Step 4, heating water bath in essence is added in preservative, obtains the second mixed solution；
Step 5, second mixed solution is added in the lotion, vacuum suction, obtains described containing hyaluronic acid
Toothpaste.
In step 1, the charging sequence of the hyaluronic acid, D-sorbite and sweetener can be sequentially add it is described
In deionized water；
It is also possible to for the hyaluronic acid, D-sorbite and sweetener being uniformly mixed, is then added in deionized water.
In step 2, the foaming agent is added in the rubbing agent, stirs evenly under room temperature, obtains mixed-powder.
In step 3, first mixed solution is stirred on side, and it is molten that first mixing is added to while by the mixed-powder
It in liquid, is stirred evenly after charging, obtains lotion, do not limited specifically generally for mixing time and revolving speed, only
It wants that lotion can be obtained.
In step 4, the preservative is added in the essence, 10-40min is heated in 40-60 DEG C of water-bath, sufficiently
Dissolution, obtains the second mixed solution.The time of above-mentioned bath temperature and heating can determine that sufficiently dissolution is according to the actual situation
It can.
In steps of 5, second mixed solution is added slowly in the lotion when stirring the lotion, stirring is equal
After even, vacuum suction, vacuum degree (relative pressure) is -0.096~-0.1Mpa, obtains the toothpaste containing hyaluronic acid.
By adding hyaluronic acid, D-sorbite, sweetener, friction with the ratio limited in preparation method of the invention
Agent, foaming agent, preservative, essence can prepare moisture retention, the higher toothpaste containing hyaluronic acid of safety.
In one preferred embodiment, the molecular weight of the hyaluronic acid is 800KDa-1200KDa；The molecular weight
Hyaluronic acid in range has stronger water-retaining property, is hardened so that the toothpaste will not dry out.
In a specific embodiment, the composition relative to 100 parts by weight of total weight, the hyaluronic acid contain
Amount is 0.1-10 parts by weight；The content of the D-sorbite is 1-5 parts by weight.
In one preferred embodiment, the composition relative to 100 parts by weight of total weight, the hyaluronic acid contain
Amount is 0.1-1 parts by weight；The content of the D-sorbite is 1-2 parts by weight.Sorb greatly reduces compared with prior art
The content of sugar alcohol, so that the safety of the toothpaste is higher.
Following embodiment of the invention is only used to illustrate realization a specific embodiment of the invention, these embodiments cannot
It is not understood as limitation of the present invention.It is other it is any change made by without departing from the spirit and principles of the present invention,
Modification, combination, simplifies substitution, is accordingly to be regarded as equivalent substitute mode, falls within the scope and spirit of the invention.
Embodiment
Experimental method used in following embodiments is such as conventional method without particular/special requirement.
Material as used in the following examples, reagent etc., are commercially available unless otherwise specified.
Embodiment 1
Weighing the hyaluronic acids of 0.2g (0.2 parts by weight of parts by weight of the total amount relative to composition) respectively, (molecular weight is
1200KDa), the D-sorbite of 2g and 0.2g saccharin sodium are added stirring and dissolving in 84.6g deionized water to obtain the first mixing molten
Liquid；
It takes 2g sldium lauryl sulfate to be added in the silica of 10g, is uniformly mixing to obtain mixed-powder；
Above-mentioned mixed-powder is added in first mixed solution, stirs evenly, obtains lotion；
0.5g sodium benzoate is added in 0.5g peppermint oil, 40 DEG C of heating water bath 20min, stirring and dissolving obtains the second mixing
Solution；
Second mixed solution is added in the lotion, vacuum suction, vacuum degree is -0.096Mpa, is obtained described
The component of toothpaste containing hyaluronic acid, the embodiment is shown in Table 1.
Comparative example 1
Weigh respectively the xanthan gum of 2g (2 parts by weight of parts by weight of the total amount relative to composition), 2g D-sorbite with
And 0.2g saccharin sodium is added stirring and dissolving in 82.8g deionized water and obtains the first mixed solution；
It takes 2g sldium lauryl sulfate to be added in the silica of 10g, is uniformly mixing to obtain mixed-powder；
Above-mentioned mixed-powder is added in first mixed solution, stirs evenly, obtains lotion；
0.5g sodium benzoate is added in 0.5g peppermint oil, 40 DEG C of heating water bath 20min, stirring and dissolving obtains the second mixing
Solution；
Second mixed solution is added in the lotion, vacuum suction, vacuum degree is -0.096Mpa, is obtained described
The component of toothpaste containing hyaluronic acid, the embodiment is shown in Table 1.
Comparative example 2
The D-sorbite and 0.2g saccharin sodium for weighing 60g respectively are added stirring and dissolving in 21.6g deionized water and obtain the
One mixed solution；
It takes 2g sldium lauryl sulfate to be added in the hydrated silica of 15g, is uniformly mixing to obtain mixed-powder；
Above-mentioned mixed-powder is added in first mixed solution, stirs evenly, obtains lotion；
0.5g sodium benzoate is added in 0.5g peppermint oil, 40 DEG C of heating water bath 20min, stirring and dissolving obtains the second mixing
Solution；
Second mixed solution is added in the lotion, vacuum suction, vacuum degree is -0.096Mpa, is obtained described
The component of toothpaste containing hyaluronic acid, the embodiment is shown in Table 1.
Comparative example 3
Weighing the hyaluronic acids of 0.2g (0.2 parts by weight of parts by weight of the total amount relative to composition) respectively, (molecular weight is
1200KDa), 0.2g saccharin sodium is added stirring and dissolving in 86.6g deionized water and obtains the first mixed solution；
It takes 2g sldium lauryl sulfate to be added in the silica of 10g, is uniformly mixing to obtain mixed-powder；
Above-mentioned mixed-powder is added in first mixed solution, stirs evenly, obtains lotion；
0.5g sodium benzoate is added in 0.5g peppermint oil, 40 DEG C of heating water bath 20min, stirring and dissolving obtains the second mixing
Solution；
Second mixed solution is added in the lotion, vacuum suction, vacuum degree is -0.096Mpa, is obtained described
The component of toothpaste containing hyaluronic acid, the embodiment is shown in Table 1.
Embodiment 2
Weighing the hyaluronic acids of 0.2g (0.2 parts by weight of parts by weight of the total amount relative to composition) respectively, (molecular weight is
1500KDa), the D-sorbite of 2g and 0.2g saccharin sodium are added stirring and dissolving in 84.6g deionized water to obtain the first mixing molten
Liquid；
It takes 2g sldium lauryl sulfate to be added in the silica of 10g, is uniformly mixing to obtain mixed-powder；
Above-mentioned mixed-powder is added in first mixed solution, stirs evenly, obtains lotion；
0.5g sodium benzoate is added in 0.5g peppermint oil, 40 DEG C of heating water bath 20min, stirring and dissolving obtains the second mixing
Solution；
Second mixed solution is added in the lotion, vacuum suction, vacuum degree is -0.096Mpa, is obtained described
The component of toothpaste containing hyaluronic acid, the embodiment is shown in Table 1.
Embodiment 3
Weighing the hyaluronic acids of 0.2g (0.2 parts by weight of parts by weight of the total amount relative to composition) respectively, (molecular weight is
800KDa), the D-sorbite of 2g and 0.2g saccharin sodium are added stirring and dissolving in 84.6g deionized water to obtain the first mixing molten
Liquid；
It takes 2g sldium lauryl sulfate to be added in the silica of 10g, is uniformly mixing to obtain mixed-powder；
Above-mentioned mixed-powder is added in first mixed solution, stirs evenly, obtains lotion；
0.5g sodium benzoate is added in 0.5g peppermint oil, 40 DEG C of heating water bath 20min, stirring and dissolving obtains the second mixing
Solution；
Second mixed solution is added in the lotion, vacuum suction, vacuum degree is -0.096Mpa, is obtained described
The component of toothpaste containing hyaluronic acid, the embodiment is shown in Table 1.
Embodiment 4
Weighing the hyaluronic acids of 0.2g (0.2 parts by weight of parts by weight of the total amount relative to composition) respectively, (molecular weight is
500KDa), the D-sorbite of 2g and 0.2g saccharin sodium are added stirring and dissolving in 84.6g deionized water to obtain the first mixing molten
Liquid；
It takes 2g sldium lauryl sulfate to be added in the silica of 10g, is uniformly mixing to obtain mixed-powder；
Above-mentioned mixed-powder is added in first mixed solution, stirs evenly, obtains lotion；
0.5g sodium benzoate is added in 0.5g peppermint oil, 40 DEG C of heating water bath 20min, stirring and dissolving obtains the second mixing
Solution；
Second mixed solution is added in the lotion, vacuum suction, vacuum degree is -0.096Mpa, is obtained described
The component of toothpaste containing hyaluronic acid, the embodiment is shown in Table 1.
Embodiment 5
Weighing the hyaluronic acids of 0.2g (0.2 parts by weight of parts by weight of the total amount relative to composition) respectively, (molecular weight is
1000KDa), the D-sorbite of 2g and 0.2g saccharin sodium are added stirring and dissolving in 84.6g deionized water to obtain the first mixing molten
Liquid；
It takes 2g sldium lauryl sulfate to be added in the silica of 10g, is uniformly mixing to obtain mixed-powder；
Above-mentioned mixed-powder is added in first mixed solution, stirs evenly, obtains lotion；
0.5g sodium benzoate is added in 0.5g peppermint oil, 40 DEG C of heating water bath 20min, stirring and dissolving obtains the second mixing
Solution；
Second mixed solution is added in the lotion, vacuum suction, vacuum degree is -0.096Mpa, is obtained described
The component of toothpaste containing hyaluronic acid, the embodiment is shown in Table 1.
Embodiment 6
Weighing the hyaluronic acids of 10g (10 parts by weight of parts by weight of the total amount relative to composition) respectively, (molecular weight is
1000KDa), the D-sorbite of 5g and 0.5g maltitol are added stirring and dissolving in 55g deionized water to obtain the first mixing molten
Liquid；
It takes 2.5g lauryl sodium sulfate to be added in the calcium carbonate of 25g, is uniformly mixing to obtain mixed-powder；
Above-mentioned mixed-powder is added in first mixed solution, stirs evenly, obtains lotion；
0.5g potassium sorbate is added in 1.5g wintergreen, 40 DEG C of heating water bath 20min, stirring and dissolving obtains the second mixing
Solution；
Second mixed solution is added in the lotion, vacuum suction, vacuum degree is -0.096Mpa, is obtained described
The component of toothpaste containing hyaluronic acid, the embodiment is shown in Table 1.
Embodiment 7
Weighing the hyaluronic acids of 0.1g (0.1 parts by weight of parts by weight of the total amount relative to composition) respectively, (molecular weight is
1000KDa), the D-sorbite of 1g and 0.1g cyclohexylamine sulfonic acid sodium are added stirring and dissolving in 86.2g deionized water and obtain first
Mixed solution；
It takes 1.5gN- sodium lauroyl sarcosine to be added in the aluminium hydroxide of 10g, is uniformly mixing to obtain mixed-powder；
Above-mentioned mixed-powder is added in first mixed solution, stirs evenly, obtains lotion；
0.1g potassium sorbate is added in 1g wintergreen, 40 DEG C of heating water bath 20min, it is molten that stirring and dissolving obtains the second mixing
Liquid；
Second mixed solution is added in the lotion, vacuum suction, vacuum degree is -0.096Mpa, is obtained described
The component of toothpaste containing hyaluronic acid, the embodiment is shown in Table 1.
Embodiment 8
Weighing the hyaluronic acids of 1g (1 parts by weight of parts by weight of the total amount relative to composition) respectively, (molecular weight is
1000KDa), the D-sorbite of 2g and 0.3g cyclohexylamine sulfonic acid sodium are added stirring and dissolving in 78.2g deionized water and obtain first
Mixed solution；
It takes 2gN- sodium lauroyl sarcosine to be added in the calcium bicarbonate of 15g, is uniformly mixing to obtain mixed-powder；
Above-mentioned mixed-powder is added in first mixed solution, stirs evenly, obtains lotion；
0.3g potassium sorbate is added in 1.2g wintergreen, 40 DEG C of heating water bath 20min, stirring and dissolving obtains the second mixing
Solution；
Second mixed solution is added in the lotion, vacuum suction, vacuum degree is -0.096Mpa, is obtained described
The component of toothpaste containing hyaluronic acid, the embodiment is shown in Table 1.
Embodiment 9
Weighing the hyaluronic acids of 5g (5 parts by weight of parts by weight of the total amount relative to composition) respectively, (molecular weight is
1000KDa), the D-sorbite of 3g and 0.4g cyclohexylamine sulfonic acid sodium are added stirring and dissolving in 75.1g deionized water and obtain first
Mixed solution；
It takes 2.3gN- sodium lauroyl sarcosine to be added in the calcium bicarbonate of 13g, is uniformly mixing to obtain mixed-powder；
Above-mentioned mixed-powder is added in first mixed solution, stirs evenly, obtains lotion；
0.4g potassium sorbate is added in 0.8g wintergreen, 40 DEG C of heating water bath 20min, stirring and dissolving obtains the second mixing
Solution；
Second mixed solution is added in the lotion, vacuum suction, vacuum degree is -0.096Mpa, is obtained described
The component of toothpaste containing hyaluronic acid, the embodiment is shown in Table 1.
Embodiment 10
Weighing the hyaluronic acids of 2g (2 parts by weight of parts by weight of the total amount relative to composition) respectively, (molecular weight is
1000KDa), the D-sorbite of 3g and 0.4g cyclohexylamine sulfonic acid sodium are added stirring and dissolving in 78.1g deionized water and obtain first
Mixed solution；
It takes 2.3gN- sodium lauroyl sarcosine to be added in the calcium bicarbonate of 13g, is uniformly mixing to obtain mixed-powder；
Above-mentioned mixed-powder is added in first mixed solution, stirs evenly, obtains lotion；
0.4g potassium sorbate is added in 0.8g wintergreen, 40 DEG C of heating water bath 20min, stirring and dissolving obtains the second mixing
Solution；
Second mixed solution is added in the lotion, vacuum suction, vacuum degree is -0.096Mpa, is obtained described
The component of toothpaste containing hyaluronic acid, the embodiment is shown in Table 1.
Comparative's table of each embodiment of table 1
1) water retention test
15g lotion is weighed respectively, is placed in plate, keeps lotion equal with air contact area, is 20 DEG C in temperature, phase
Under conditions of being 60% to humidity, with the fluid loss of weight method measurement toothpaste.
Test measurement three times in parallel, average value is shown in Table 2 three times.
Table 2
| Sample | 12h fluid loss | Fluid loss for 24 hours | 48h fluid loss |
| Embodiment 1 | 2.31 | 3.69 | 5.17 |
| Embodiment 2 | 2.63 | 4.01 | 5.81 |
| Embodiment 3 | 2.42 | 3.91 | 5.41 |
| Embodiment 4 | 2.69 | 4.02 | 5.63 |
| Embodiment 5 | 2.25 | 3.58 | 5.09 |
| Embodiment 6 | 2.45 | 4.13 | 5.89 |
| Embodiment 7 | 2.26 | 3.54 | 5.11 |
| Embodiment 8 | 2.27 | 3.51 | 5.09 |
| Embodiment 9 | 2.38 | 3.71 | 5.28 |
| Embodiment 10 | 2.36 | 3.70 | 5.25 |
| Comparative example 1 | 4.88 | 5.61 | 6.53 |
| Comparative example 2 | 4.10 | 5.47 | 6.62 |
| Comparative example 3 | 3.09 | 4.25 | 5.95 |
As can be seen from Table 2, the fluid loss compared with comparative example 1- comparative example 3 of embodiment 1- embodiment 10 is lower, to say
The bright toothpaste water-retaining property containing hyaluronic acid prepared through the invention is preferable, without add hyaluronic acid toothpaste fluid loss compared with
It is high.
2) stability test
Toothpaste prepared by embodiment 1- embodiment 10 and comparative example 1- comparative example 3 is stablized according to GB8372-2017
Property detection, stored 8 hours using -8 DEG C of refrigerators, take out and place 45 DEG C baking oven 8 hours, restore room temperature.
The results are shown in Table 3.
Table 3
As can be seen from Table 3, it after embodiment 1- embodiment 10 and comparative example 1 are tested 3 months, has good stability, and passes through
Comparative example 2,3 is found out, only adds D-sorbite and only addition polymer hyaluronic acid stability is poor, be unfavorable for the storage of toothpaste
It deposits.
Claims (10)
1. a kind of toothpaste containing hyaluronic acid, which is characterized in that comprising molecular weight be 500KDa-1500KDa hyaluronic acid, rub
Liniment, foaming agent, sweetener, preservative, essence, D-sorbite, deionized water.
2. the toothpaste according to claim 1 containing hyaluronic acid, which is characterized in that the molecular weight of the hyaluronic acid is
800KDa-1200KDa。
3. the toothpaste according to claim 1 containing hyaluronic acid, which is characterized in that relative to 100 parts by weight of total weight
Composition, the content of the hyaluronic acid are 0.1-10 parts by weight；The content of the D-sorbite is 1-5 parts by weight.
4. the toothpaste according to claim 3 containing hyaluronic acid, which is characterized in that relative to 100 parts by weight of total weight
Composition, the content of the hyaluronic acid are 0.1-1 parts by weight；The content of the D-sorbite is 1-2 parts by weight.
5. the toothpaste according to claim 1 containing hyaluronic acid, which is characterized in that relative to 100 parts by weight of total weight
Composition, the content of the rubbing agent is 10-25 parts by weight, and the rubbing agent is selected from aluminium hydroxide, silica, calcium carbonate
And at least one of calcium bicarbonate.
6. the toothpaste according to claim 1 containing hyaluronic acid, which is characterized in that relative to 100 parts by weight of total weight
Composition, the content of the foaming agent is 1.5-2.5 parts by weight, and the foaming agent is selected from sldium lauryl sulfate, dodecyl
At least one of sodium sulphate, N- sodium lauroyl sarcosine.
7. the toothpaste according to claim 1 containing hyaluronic acid, which is characterized in that relative to 100 parts by weight of total weight
Composition, the content of the sweetener is 0.1-0.5 parts by weight, and the sweetener is selected from saccharin sodium, maltitol, cyclohexylamine
Sodium sulfonate is at least one.
8. the toothpaste according to claim 1 containing hyaluronic acid, which is characterized in that relative to 100 parts by weight of total weight
The content of composition, the preservative is 0.1-0.5 parts by weight, and the preservative is in potassium sorbate, sodium benzoate
It is at least one.
9. the toothpaste according to claim 1 containing hyaluronic acid, which is characterized in that relative to 100 parts by weight of total weight
Composition, the content of the essence is 0.5-1.5 parts by weight, and the essence is selected from least one of peppermint oil, wintergreen.
10. a kind of preparation method of the toothpaste containing hyaluronic acid, the preparation method are characterised by comprising following steps:
It is molten by the first mixing is obtained in hyaluronic acid, D-sorbite and sweetener the addition deionized water of 500KDa-1500KDa
Liquid；
Foaming agent is added in rubbing agent and obtains mixed-powder；
The mixed-powder is added in first mixed solution and obtains lotion；
Heating water bath in essence is added in preservative, obtains the second mixed solution；
Second mixed solution is added in the lotion, vacuum suction, obtains the toothpaste containing hyaluronic acid.
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