CN1732897A - Face-beautifying skin-caring lotion with leech extract and its preparation process - Google Patents
Face-beautifying skin-caring lotion with leech extract and its preparation process Download PDFInfo
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- CN1732897A CN1732897A CN 200510036509 CN200510036509A CN1732897A CN 1732897 A CN1732897 A CN 1732897A CN 200510036509 CN200510036509 CN 200510036509 CN 200510036509 A CN200510036509 A CN 200510036509A CN 1732897 A CN1732897 A CN 1732897A
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Abstract
The invention discloses a face-beautifying skin-caring lotion, which is prepared from leech extract, auxiliary material and clean water through dissolving the leech extract and auxiliary material completely into water.
Description
Technical field
The present invention relates to a kind of daily-use chemical industry articles for use, cosmetics of a kind of specifically cosmetics, specific use and preparation method thereof.
Background technology
Healthy and beauty is human unremitting pursuit, people are more and more stronger to the demand of cosmetics and skincare product, but a lot of people's cosmetics knowledge is very limited, judge the quality of cosmetics, only rest on the use feeling to cosmetics, and shortage is to the judgement of cosmetics result of use scientific rationality.Because cosmetics and skincare product is various in style at present, from raw material, people have used various raw materials to make cosmetics and skincare product, and are as milk, Placenta extract, albumen, lactic acid, various vitamin, various Chinese herbal medicine etc., that the past has even use virulent heavy metal lead.What have has better action to beauty and skin care, but has used deleterious raw material not only can not play beautification function, on the contrary human body is caused great harm, so the cosmetics and skincare product that everyone should select to oneself being fit to is necessary.In addition, except raw material, selecting suitable form also is an important factor, cosmetics and skincare product can be divided into cream kind by its form, the emulsion class, the powder class, liquid type etc., can be divided into the cleaning class according to purposes, skin type, whitewash class etc., the product that is used to improve looks generally is divided into cosmetics and skincare product and cosmetics two big series, producing cream kind, the emulsion class, in the cosmetics and skincare product of powder class or the process of cosmetics, a lot of oil preparationes that add a moisture-keeping function are arranged, these product oiliness that add oil preparation are big, feel greasy, after wash, washing off, just do not feel, life-time service can not have the improvement of essence to skin
In order to reach better cosmetic purpose, in recent years, along with science and technology development, particularly infiltration and the application of biological medicine technology in cosmetics manufacturing field, many in the world medicine and biotechnology expert throw oneself in the research of cosmetics, a feast for the eyes various beauty and skin care cosmetics have also appearred on the market, public publication has also been published the production method and the prescription of many beauty and skin care cosmetics, as Chinese patent＜application number〉92107760,＜denomination of invention〉fish oil cosmetics and preparation method, the composition of raw materials of changing piece product comprises: octadecanol, white oil, nipalgin second cheese, silicone oil, single sweet cheese and water, and added the fish oil of 5-10% therein, fish oil joins simultaneously with other composition of raw materials, mixes, heating, stir, mill, emulsifying, cooling, fill.Chinese patent＜application number〉92114173,＜denomination of invention〉freckle-removing cream and manufacture method thereof, its component and each components in proportions are: ascorbic acid benzene can 3-8%, stearic alkali 10%, glycerol 5%, octadecanol 1%, titanium dioxide are admired 2%, salicylic acid 0.5%, glycerol monostearate cheese 1%, ethanol: 3: 1 mixed solvent 77.5-72.5% of dimethyl sulfoxine.This product safety is nontoxic, and is without any side effects, goes the speckle ability strong, applied widely, is coated with 2-3 month, can eliminate the pigment obstacle speckle of facial influence beauty treatment, especially pigmentation after the laser surgery had fabulous removing spots and whitening effect.Chinese patent＜application number〉93H5858,＜denomination of invention〉formula for skin-refreshing lotion of evening primrose oil and manufacture method, adopt Radix Oenotherae erythrosepalae oil, the vitamin E of certain proportioning, stearic acid, octadecanol, glyceryl monostearate, essence, 12 ether nitrogen mile ketone, triethanolamine, liquid paraffin etc. are through heating, stir and be processed into the effect that it has softening skin blood capillary, skin keratin.
From open source literature; the present cosmetics raw material of producing; main by oils and fats, fatty acid or fatty acid cheese, organic solvent, spice, nutrient, have the one-tenth such as medicine of certain function to be grouped into; what have has also added some bioactive substances; make cosmetics can safeguard the normal physiological function of skin; and can promote cell metabolism, control or regulate the skin aging process, to delay skin aging, the protection damaged skin.
In addition, studying and producing in the process of conventional cosmetics, people also recognize, the somebody also needs mottle, acne are treated except the needs beauty and skin care, so, open source literature has also been reported the cosmetics of some treatment mottles, acne, as Chinese patent＜application number〉02144666,＜denomination of invention〉acne ointment, cosmetics one acne ointment of the present invention is two kinds of components of A, B by erythromycin lactobionate 10-20 part, metronidazole 150-250 part, substrate; Substrate A component adopts: hexadecanol, white oil, sheep stearic acid glycerol, polyoxyethylene 20 units, antiseptic are an amount of: the B component adopts: glycerol, distilled water, dimension C, dimension A, dimension E, spice are an amount of.To staphylococcus, streptococcal infection, the skin infection pathogen that anthrax bacillus, anaerobe, propionibacterium acnes etc. cause has good antibacterial activity through clinical practice in the present invention.Can suppress to kill propionibacterium acnes and some other responsive strains, reduce the generation of lipase.
Make a general survey of the various cosmetics of selling in the market, the molecular weight that is characterized in active substance all several ten thousand to more than the hundreds of thousands, as SOD commonly used, its molecular weight is more than 30,000, hyaluronic acid is then up to more than 300,000, these materials can't be absorbed by skin, this be because, scientific research shows, under the normal condition, skin can only absorb the material of molecular weight≤8000, in view of this, the inventor gropes and puts into practice through secular, finally sum up Hirudo extract and preparation method thereof, and the patent of invention of having applied for " Hirudo extract cosmetics and preparation method thereof ",＜application number〉03140487, this disclosure of the Invention a kind of cosmetics, it comprises Hirudo extract, oils and fats, fatty acid ester, organic solvent, spice, nutrient and Purified Water, preparation method is a certain proportion of oils, fatty acid ester, after organic solvent and an amount of Purified Water mix, be heated to 60-90 ℃, it is merged, add Hirudo extract and an amount of essence when treating its cool to room temperature again, fully stir then and make it fully evenly to obtain product.But the weak point of these cosmetics is Hirudo extract will be joined in cosmetic base such as oils and fats, the fatty acid ester etc. to use, and with aftersensation greasy sensation is arranged on the face, and the crowd who so not too is fit to hot season and oily skin uses.
Summary of the invention
Technical problem to be solved by this invention is to design a kind of beauty and skin care formula of liquid, and to reach easy to use, to absorb soon, effect significantly and the problem that has solved the greasy feeling that cosmetics such as oils and fats, fatty acid ester exist.
Technical scheme of the present invention is achieved in that
Face-beautifying skin-caring lotion with leech extract comprises Hirudo extract, adjuvant and pure water, and it is composed as follows:
Hirudo extract 1～99%
Adjuvant 0～50%
The pure water surplus
Above-described Hirudo extract is based on natural hirudin, and concrete grammar is at first to extract its leachate or saliva from Hirudo stem body or live body, promptly obtains Hirudo extract then after centrifugal remove impurity, ultrafiltration, chromatography and sterilization.Its liquid Hirudo cellulose content is 15-150AT-U/ml, and its lyophilized powder hirudin content is 6000-20000AT-U/g.Also can be undertaken by the extracting method that the Chinese patent " cultural method of Hirudinaria manillensis and the extracting method of hirudin " (application number 03113566.8) of inventor's application is introduced, but Hirudinaria manillensis can also substitute with other Hirudo such as blood-eating hirudo, excellent stricture of vagina cattle trematodiasis, temmoku trematodiasis, haemadipsa japonica and Haemadipsa hainana etc., and this Hirudo extract also contains various active materials such as fibrinolytic enzyme, prostaglandin simultaneously.
The above Hirudo extract liquid can carry out this Hirudo extract liquid long preservation after the lyophilization, adds in the live vol ratio during use to get final product again.
Above-described adjuvant comprises the water-soluble non-oil substances raw material that is suitable on the cosmetics easily, as hyaluronic acid, heparin sodium, Chinese herbal medicine extract, trehalose, Margarita hydrolyzed solution, sheep placental extract liquid, protease etc.
Above-described adjuvant also comprises various facial mask powders, as spot-removing facemask powder, face pack powder for skin whitening etc., and the subsides of various facial film, as the subsides of wrinkle removal facial film, the bean flour film subsides etc. of dispelling.
Above-described clean water comprises the pure water after water for injection, distilled water, double distilled water or the sterilization.
Below introduce the production method of face-beautifying skin-caring lotion with leech extract of the present invention:
By weight percentage, at room temperature, earlier Hirudo extract is mixed with water or, fully mix with adjuvant again or dissolving fully, promptly obtain product of the present invention with behind the water dissolution Hirudo extract lyophilized powder.
The present invention compared with prior art, its outstanding substantive distinguishing features and obvious improvement is:
1, cosmetics of the present invention have speckle dispelling, anti-acne, skin moistening, skin care, whiten, prevent skin aging, strengthen the effect of skin elasticity, and the treatment and the prevention of face's acne, seborrheic dermatitis, rosacea had unique effect.Its effect of eliminating acne, seborrheic dermatitis is based on the effective ingredient of hirudin, can eliminate the inflammation in the pilosebaceous unit pipe after the use, makes it to recover the health of skin, is a kind of safe, efficient, green pure natural cosmetics.
2, at present traditional aqueous cosmetic and the general oil content of oil-based cosmetic preparation are higher, they mainly are by forming one deck oil film at skin surface, play the physics skin care effect, a lot of people get used to this class oil-based cosmetic preparation, the shopgirl often hears that customer response cosmetics oiliness is arranged is low, yet there is the people of cosmetics knowledge all to know slightly, the breathability of oil film is poor, cutaneous eupnea and physiological activity, produce vexed greasy not well sensation, its moisturizing effect also only limits to skin surface, now high in technological content cosmetics all are aqueouss, product of the present invention be with water miscible material as substrate, its skin corium that can directly penetrate to the skin, automatically pin the thin film of moisture in subcutaneous formation, the powerful moisture-keeping function of tool, competent moisture is sparkling and crystal-clear bright by skin, and does not stop up pore, salubrious especially nature after using allows the people have that Mu Haifeng's is happy.Making skin still keep bright and beautiful in windy and exsiccant season moistens.
3, skin protection and skin care be we can say, traditional cosmetics can only play general skin care effect, oiliness is big, feel greasy, after wash, washing off, just do not feel, life-time service can not have the improvement of essence to skin, and product of the present invention has three kinds of effects simultaneously: 1. molecular weight is little, except that itself can own skin permeation deep layer, also help the infiltration of other material, thereby play the effect of fast Absorption; 2. hirudin is a kind of low molecular polypeptide, can provide nutrient substance for skin, and easily be absorbed utilization; 3. can blood viscosity lowering, accelerate blood flow rate, improve blood circulation, promote the metabolism of cell, make skin obtain prescribing adequate nutrition, thereby the skin pale delicacy that becomes, play the effect of skin protection skin care wrinkle removing.
The specific embodiment
Below be embodiments of the invention:
Embodiment 1
Hirudo extract (natural hirudin content 30AT-U/ml) 100ml
Distilled water 1400ml
Promptly become face-beautifying skin-caring lotion with leech extract (natural hirudin content is 20AT-U/ml) after above-mentioned two kinds of liquid are fully mixed.
Embodiment 2
Hirudo extract lyophilized powder (natural hirudin content 16000AT-U/g) 0.5g (8000AT-U)
Sterile purified water 4000ml
Method for making: with Hirudo extract lyophilized powder 0.5 gram (8000AT-U) put into the 4000ml sterile purified water make it to dissolve fully face-beautifying skin-caring lotion with leech extract.
Embodiment 3
Hirudo extract 100ml, seaweed extracted liquor 150ml, Radix Salviae Miltiorrhizae extract 150ml, sterile purified water 1100ml, with after above-mentioned four kinds of liquid mixing face-beautifying skin-caring lotion with leech extract.
Embodiment 4
Hirudo extract 50ml, hyaluronate sodium 1.5 grams, Margarita hydrolyzed solution 100ml, sheep placental extract liquid 30ml, liquid compound preservative 20ml, double distilled water 600ml.After hyaluronate sodium being dissolved fully earlier, add three kinds of remaining liquid more respectively with double distilled water, fully stir face-beautifying skin-caring lotion with leech extract.
Embodiment 5
Hirudo extract 100ml, Hydrolyzed protein liquid 100ml, Ganoderma extracting solution 200ml, liquid compound preservative 20ml, water for injection 1080ml promptly become face-beautifying skin-caring lotion with leech extract after aforesaid liquid fully mixed.
Embodiment 6
Hirudo extract lyophilized powder (natural hirudin content 16000AT-U/g) 1g, hyaluronate sodium 3g, liquid compound preservative 20ml, distilled water 2880ml.Hirudo extract freeze-dried powder, hyaluronic acid are fully dissolved successively earlier with distilled water, and then mix with the liquid compound preservative face-beautifying skin-caring lotion with leech extract.
Embodiment 7
Hirudo extract lyophilized powder (natural hirudin content 16000AT-U/g) 1g, heparin sodium 3g, liquid compound preservative 20ml, distilled water 2500ml.Earlier with distilled water with Hirudo extract freeze-dried powder, heparin sodium fully dissolving successively, and then mix with the liquid compound preservative face-beautifying skin-caring lotion with leech extract.
Embodiment 8
Hirudo extract 50ml, hyaluronate sodium 1.5 grams, papain 10 grams, sheep placental extract liquid 30ml, liquid compound preservative 20ml, double distilled water 800ml.Add three kinds of remaining liquid after hyaluronate sodium being dissolved fully earlier more respectively with double distilled water, fully stir face-beautifying skin-caring lotion with leech extract.
Embodiment 9
Hirudo extract 100ml, clean water 900ml, face pack powder for skin whitening 800g with after Hirudo extract and the clean water mixing, put into facial mask powder again and stir earlier, promptly become the Hirudo extract beauty skin-care face mask.
Embodiment 10
Hirudo extract 100ml, clean water 100ml, freckle-removing mask paste 40, earlier Hirudo extract and clean water are mixed, and again facial film are pasted to put into wherein and soak, and promptly become the Hirudo extract beauty skin-care face mask and paste.
Product skin effect of the present invention
Application Example 1
Liao, man, 18 years old, middle school, Nanning Senior Two student.Grow a lot of acne before 3 months on the face, once used the erythromycin ointment treatment, poor effect.Skin care liquid through adopting present embodiment one prescription to make, every day early, middle and late respectively smearing once, be coated with three times at every turn, every all over being separated by 3～10 minutes, use 3 days continuously after, acne diminish, color is thin out, after using 10 days continuously again, the acne complete obiteration, face becomes and is rich in gloss, does not stay any cicatrix markings.
Application Example 2
Mrs Guo, 40 years old, the laboratorian of Pingguo, Guangxi aluminum company, skin is greyish black on the face, once tried out much to brighten skin care liquid, but effect is not really desirable, the skin care liquid of making through the prescription that adopts present embodiment three, every day, early, middle and late respectively smearing once was coated with three times at every turn, and be every all over being separated by 3～10 minutes, use after 15 days continuously, color is thin out, use 30 days continuously again after, face's grey black has been eliminated half.
Application Example 3
Tan XX, the man, 38 years old, Beihai, Guangxi civil servant, because operating pressure is big, often worked overtime the late into the night in evening over the past two years.Lethargy, facial skin dimness, shortage gloss.Use skincare liquid of the present invention just to produce effect after 5 days, facial skin is full after 15 days, progressively recovers gloss.
Application Example 4
Dragon XX, the woman, 18 years old, the Guangxi Yulin worker of enterprise, facial skin is coarse, and pore is bigger, uses skincare liquid of the present invention just to produce effect after 3 days, and skin becomes fine and smooth gradually and is rich in gloss.
Application Example 5
Yellow XX, the man, 20 years old, Nanning people from city, face head goes up a lot of acne the year before, and through treating with methods such as antibiotic, its effect is relatively poor, also stays the black vestige simultaneously.Facial film through making with the prescription of this patent pastes, and once a day, after one week of logotype, acne gradually reduce and disappear, and continues to use after one month again, and all acne have disappeared and left no trace on the face.
Application Example 6
Leaf XX, woman, 25 years old, people from Zhuhai City, Guangdong Province, full face is all grown red small pox, and left cheek limit is more serious, fat secretion is many, through the facial mask powder that the prescription that uses this patent is made, per two days once, continuously after fortnight, small pox has disappeared many, serious place slowly moves back red, and skin is more glossy than in the past, exquisiteness.
Claims (5)
1, a kind of face-beautifying skin-caring lotion with leech extract is characterized in that: it is made up of Hirudo extract, adjuvant and clean water, and its material composition and quality percentage composition are as follows:
Hirudo extract 1～99%
Adjuvant 0～50%
The pure water surplus
Above-described Hirudo extract is based on natural hirudin, and it is to extract its leachate or saliva, the Hirudo extract liquid that promptly obtains after centrifugal remove impurity, ultrafiltration, chromatography and sterilization then from Hirudo stem body or live body;
Described adjuvant comprises the non-oil substances raw material that is suitable on the cosmetics soluble in water.
2, face-beautifying skin-caring lotion with leech extract according to claim 1 is characterized in that: Hirudo extract is to extract from the class Hirudo of sucking blood, and this Hirudo extract liquid can be carried out preserving after the lyophilization.
3, face-beautifying skin-caring lotion with leech extract according to claim 1, it is characterized in that: the described non-oil substances raw material that is suitable on the cosmetics soluble in water comprises hyaluronic acid, heparin sodium, Chinese herbal medicine extract, trehalose, Margarita hydrolyzed solution, sheep placental extract liquid or protease, comprises also that simultaneously various facial mask powders or facial film paste.
4, face-beautifying skin-caring lotion with leech extract according to claim 1 is characterized in that: described pure water comprises the pure water after water for injection, distilled water, double distilled water or the sterilization.
5, the production method of face-beautifying skin-caring lotion with leech extract as claimed in claim 1 is characterized in that: by weight percentage, and at room temperature, earlier Hirudo extract is mixed with water or with behind the water dissolution Hirudo extract lyophilized powder, fully mix with adjuvant again, or dissolving fully, product promptly obtained.
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Cited By (17)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN101332211B (en) * | 2008-08-06 | 2010-09-29 | 山东大学 | Leech extract and preparation method and use thereof |
| CN102178635A (en) * | 2011-04-27 | 2011-09-14 | 重庆时珍阁普生药业有限公司 | Use of leech for cleaning skin, skin cleaning composition and preparation method thereof |
| CN102188360A (en) * | 2011-04-27 | 2011-09-21 | 重庆时珍阁普生药业有限公司 | Application of leech to improvement of black eyes or eye puffiness, composition and preparation method of composition |
| CN102188359A (en) * | 2011-04-27 | 2011-09-21 | 重庆时珍阁普生药业有限公司 | Application of leech to nursing of hair or scalp of head, composition and preparation method |
| CN103961304A (en) * | 2014-05-26 | 2014-08-06 | 路明芳 | Traditional Chinese medicine mask for removing freckles |
| CN104784063A (en) * | 2015-04-07 | 2015-07-22 | 巫远程 | Compound for beauty and skincare product as well as manufacturing method of the compound |
| CN105078802A (en) * | 2014-05-15 | 2015-11-25 | 钱如力 | Acidic polypeptide transdermal caring agent and method for preparing same |
| CN106265462A (en) * | 2016-10-20 | 2017-01-04 | 荆州市民康生物科技有限公司 | A kind of component-type freckle-removing beauty cream and preparation method |
| CN106344483A (en) * | 2016-08-29 | 2017-01-25 | 重庆志微生物技术有限公司 | Hirudo nipponia acne removal face cream, preparation method and application of hirudo nipponia acne removal face cream |
| CN106726804A (en) * | 2016-12-16 | 2017-05-31 | 张新 | A kind of skin care bacterium peptide liquid and preparation method thereof |
| CN107308099A (en) * | 2017-08-15 | 2017-11-03 | 广西壮族自治区药用植物园 | Leech ultra micro powder cosmetic of anti-wrinkle whitening and preparation method thereof |
| CN107823637A (en) * | 2017-11-29 | 2018-03-23 | 安徽中医药大学 | A kind of leech peptide albumen cream and its preparation method and application |
| CN107854326A (en) * | 2017-12-19 | 2018-03-30 | 乳山寰海生物科技有限公司 | A kind of hirudin moistens face moisturizing maintenance Essence |
| CN108619069A (en) * | 2018-06-25 | 2018-10-09 | 周美英 | A kind of artificial tooth thimerosal and preparation method thereof |
| CN109381357A (en) * | 2018-12-13 | 2019-02-26 | 广州宝莱生物科技有限公司 | A kind of anti-acne moisturizing leech freeze-dried powder |
| CN109602681A (en) * | 2019-01-15 | 2019-04-12 | 昆明学院 | Application of the leech body surface secretion in preparation anti-inflammatory anti-acne skin care item |
| CN115177639A (en) * | 2022-08-01 | 2022-10-14 | 海南医学院 | Application of leech extract in preparation of analgesic |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN101332211B (en) * | 2008-08-06 | 2010-09-29 | 山东大学 | Leech extract and preparation method and use thereof |
| CN102178635A (en) * | 2011-04-27 | 2011-09-14 | 重庆时珍阁普生药业有限公司 | Use of leech for cleaning skin, skin cleaning composition and preparation method thereof |
| CN102188360A (en) * | 2011-04-27 | 2011-09-21 | 重庆时珍阁普生药业有限公司 | Application of leech to improvement of black eyes or eye puffiness, composition and preparation method of composition |
| CN102188359A (en) * | 2011-04-27 | 2011-09-21 | 重庆时珍阁普生药业有限公司 | Application of leech to nursing of hair or scalp of head, composition and preparation method |
| CN102188359B (en) * | 2011-04-27 | 2012-05-30 | 重庆时珍阁普生药业有限公司 | Application of leech to nursing of hair or scalp of head, composition and preparation method |
| CN102188360B (en) * | 2011-04-27 | 2012-06-06 | 重庆时珍阁普生药业有限公司 | Application of leech to improvement of black eyes or eye puffiness, composition and preparation method of composition |
| CN102178635B (en) * | 2011-04-27 | 2012-10-10 | 重庆时珍阁普生药业有限公司 | Use of leech for cleaning skin, skin cleaning composition and preparation method thereof |
| CN105078802A (en) * | 2014-05-15 | 2015-11-25 | 钱如力 | Acidic polypeptide transdermal caring agent and method for preparing same |
| CN103961304A (en) * | 2014-05-26 | 2014-08-06 | 路明芳 | Traditional Chinese medicine mask for removing freckles |
| CN103961304B (en) * | 2014-05-26 | 2016-04-13 | 王东海 | A kind of face mask of traditional Chinese medicine for speckle dispelling |
| CN104784063A (en) * | 2015-04-07 | 2015-07-22 | 巫远程 | Compound for beauty and skincare product as well as manufacturing method of the compound |
| CN106344483A (en) * | 2016-08-29 | 2017-01-25 | 重庆志微生物技术有限公司 | Hirudo nipponia acne removal face cream, preparation method and application of hirudo nipponia acne removal face cream |
| CN106265462A (en) * | 2016-10-20 | 2017-01-04 | 荆州市民康生物科技有限公司 | A kind of component-type freckle-removing beauty cream and preparation method |
| CN106265462B (en) * | 2016-10-20 | 2020-11-27 | 荆州市民康生物科技有限公司 | Component type spot-removing beauty cream and preparation method thereof |
| CN106726804A (en) * | 2016-12-16 | 2017-05-31 | 张新 | A kind of skin care bacterium peptide liquid and preparation method thereof |
| CN107308099A (en) * | 2017-08-15 | 2017-11-03 | 广西壮族自治区药用植物园 | Leech ultra micro powder cosmetic of anti-wrinkle whitening and preparation method thereof |
| CN107823637A (en) * | 2017-11-29 | 2018-03-23 | 安徽中医药大学 | A kind of leech peptide albumen cream and its preparation method and application |
| CN107854326A (en) * | 2017-12-19 | 2018-03-30 | 乳山寰海生物科技有限公司 | A kind of hirudin moistens face moisturizing maintenance Essence |
| CN108619069A (en) * | 2018-06-25 | 2018-10-09 | 周美英 | A kind of artificial tooth thimerosal and preparation method thereof |
| CN108619069B (en) * | 2018-06-25 | 2021-06-08 | 上海典硕生物科技有限公司 | Denture disinfectant and preparation method thereof |
| CN109381357A (en) * | 2018-12-13 | 2019-02-26 | 广州宝莱生物科技有限公司 | A kind of anti-acne moisturizing leech freeze-dried powder |
| CN109381357B (en) * | 2018-12-13 | 2021-09-03 | 广州宝莱生物科技有限公司 | Leech freeze-dried powder capable of removing acne and moisturizing skin |
| CN109602681A (en) * | 2019-01-15 | 2019-04-12 | 昆明学院 | Application of the leech body surface secretion in preparation anti-inflammatory anti-acne skin care item |
| CN115177639A (en) * | 2022-08-01 | 2022-10-14 | 海南医学院 | Application of leech extract in preparation of analgesic |
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