CN107854326A - A kind of hirudin moistens face moisturizing maintenance Essence - Google Patents

A kind of hirudin moistens face moisturizing maintenance Essence Download PDF

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Publication number
CN107854326A
CN107854326A CN201711371054.9A CN201711371054A CN107854326A CN 107854326 A CN107854326 A CN 107854326A CN 201711371054 A CN201711371054 A CN 201711371054A CN 107854326 A CN107854326 A CN 107854326A
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CN
China
Prior art keywords
hirudin
skin
moisturizing maintenance
face moisturizing
maintenance essence
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Pending
Application number
CN201711371054.9A
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Chinese (zh)
Inventor
许小林
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Rushan Huanhai Biological Technology Co Ltd
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Rushan Huanhai Biological Technology Co Ltd
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Priority to CN201711371054.9A priority Critical patent/CN107854326A/en
Publication of CN107854326A publication Critical patent/CN107854326A/en
Pending legal-status Critical Current

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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/64Proteins; Peptides; Derivatives or degradation products thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/40Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
    • A61K8/42Amides
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/49Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
    • A61K8/494Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with more than one nitrogen as the only hetero atom
    • A61K8/4946Imidazoles or their condensed derivatives, e.g. benzimidazoles
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/63Steroids; Derivatives thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/64Proteins; Peptides; Derivatives or degradation products thereof
    • A61K8/65Collagen; Gelatin; Keratin; Derivatives or degradation products thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/68Sphingolipids, e.g. ceramides, cerebrosides, gangliosides
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/72Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
    • A61K8/84Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions otherwise than those involving only carbon-carbon unsaturated bonds
    • A61K8/86Polyethers
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/96Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
    • A61K8/97Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61QSPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00Preparations for care of the skin
    • A61Q19/02Preparations for care of the skin for chemically bleaching or whitening the skin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61QSPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00Preparations for care of the skin
    • A61Q19/08Anti-ageing preparations
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/40Chemical, physico-chemical or functional or structural properties of particular ingredients
    • A61K2800/59Mixtures
    • A61K2800/592Mixtures of compounds complementing their respective functions

Abstract

The invention belongs to cosmetics specialty skin care industry, and in particular to a kind of hirudin moistens face moisturizing maintenance Essence.Hirudin profit face moisturizing maintenance Essence contains:5% 20% skin conditioning agent;3~10% NMF;0.5% 10% patent hirudin;1% 10% emollient;Surplus is water.The present invention can also the antioxidant containing mass percent≤1%;Mass percent < 1% chelating agent;The preservative of mass percent≤0.5%;The present invention uses the hirudin of small molecule, the Sodium Hyaluronate of ultrahigh concentration, a variety of natural plants quintessences etc. as raw material, coordinate skin from infiltration technology, skin is penetrated into time and is supplied to nutrition needed for skin, stimulate circulation function, smooth aging microgroove, the dark and gloomy skin of brightening, plays a part of moisturizing, releives.

Description

A kind of hirudin moistens face moisturizing maintenance Essence
Technical field
The invention belongs to professional skin care industry, and in particular to a kind of hirudin moistens face moisturizing maintenance elite.
Background technology
Due to reasons such as age, environment and animations, skin can engender aging, drying, wrinkle and dark It is heavy to wait skin problem, so as to cause to lack confidence, influence attractive in appearance.Therefore to focus on skin care, improve the conventional product of these problems For essence, essence is by keeping the skin wet and Nutritional Nursing Care skin.But common essence with the addition of conditioning and moisturizing into Point, skin can only be maintained moist, but can not fundamentally solve various skin problems.
In order to which essence product has persistently smooth moisturizing effect, it will usually add the material of a variety of opsonic activities. Have very well to skin if addition and the same or similar NMF of skin itself secretion and nutritional ingredient in essence Conditioning and moisturizing effect, make it on the basis of skin moisture-keeping moistens, further conditioning protection skin, makes skin feel soft flat It is sliding, shine healthy brilliance.
Hirudin (hirudin) is that activity has been extracted in various active composition in leech (Leech) and its salivary gland most A kind of significant composition, the small protein (polypeptide) that it is made up of 65-66 amino acid.Available for treating various blood Bolt disease, may be added in skin care item, improve skin.
The content of the invention
It is an object of the invention to provide a kind of hirudin to moisten face moisturizing maintenance Essence, using the hirudin of small molecule, surpasses The Sodium Hyaluronate of high concentration, a variety of natural plants quintessences etc. are raw material, in conjunction with skin from infiltration technology so that product energy Skin is penetrated into time and is supplied to nutrition needed for skin, stimulate circulation function, smooth aging microgroove, the dark and gloomy skin of brightening, Help maintains and recovers skin self-regeneration function, makes skin health elastic.
Technical scheme is as follows:
A kind of hirudin moistens face moisturizing maintenance Essence, and it includes following component:5%~20% skin conditioning agent;3~ 20% NMF;0.5%~10% hirudin;1%~8% emollient;Surplus is water.
As the preferred of technical solution of the present invention, Essence includes following component:5%~10% skin conditioning agent;10 ~20% NMF;1%~5% hirudin;4%~6% emollient;Surplus is water.
The elite liquid product of the present invention also includes the antioxidant of mass percent≤1%;Mass percent < 1% chela Mixture;The preservative of mass percent≤1%.
Skin conditioning agent be selected from Gotu Kola P.E, collagen, purslane extract, dipotassium glycyrrhizinate, peppermint leaf extract, Pelargonium roseum extract, kuh-seng root extract, golden yellow camomile extract, aloe barbadensis Miller leaf extract, allantoin, oxybenzene More than four kinds in base propionamide benzoic acid, ceramide -3, saccharomycete lysis thing are combined.
The present invention NMF be selected from polyalcohols, ethoxy urea, DL- pyrrolidone sodium carboxylates (PCA-Na), glycine betaine, One or more combinations in Sodium Hyaluronate and serine.
The emollient of the present invention is polyalcohols, the glycerine of PEG/PPG/ polytetramethylene glycols 8/5/3, PEG/PPG-14/7 dimethyl Three kinds of combination of the above in ether, ceramide -3.Polyalcohols include 1,2- hexylene glycols, 1,2- pentanediol, 1,3-PD and Butanediol.
The emollient of the present invention is using the glycerine of PEG/PPG/ polytetramethylene glycols 8/5/3, PEG/PPG-14/7 dimethyl ethers, nerve When acid amides -3 is coordinated, mass ratio is 40~50:40~50:1.These three emollients have good amphipathic property, energy Enough skin cares, under this proportioning can the fine moistness that must control product, maintain the normal oil-water balance of skin surface, reduce It is sticky to feel and help to penetrate into skin.
The mass ratio of hirudin and saccharomycete lysis thing in the present invention is 1~5:1.Containing a variety of in saccharomycete lysis thing Amino acid (threonine, glycine, valine etc.) and disodium succinate, can shine obscure skin living, wake up skin itself strength, add Fast skin cell renewal, strengthen cell viability, improve oxygen uptake.Disodium succinate, enhancing mitochondria produce biological energy source.Oxygen uptake Increase is because have stimulated two kinds of main modes for producing energy in cellular respiration system, sugar degraded and the circulation of tricarboxylic acids.Cross Journey is exactly the chemical energy that glucose metabolism and mitochondria produce ATP forms.By hirudin and saccharomycete lysis thing in proportion Collocation uses, the effect of can speed up molecule infiltration and blood circulation, significantly more efficient promotion activating cell energy, purification row Poison, repair impaired skin.
Antioxidant in the present invention is parahydroxyacet-ophenone;The wherein mass ratio of parahydroxyacet-ophenone and 1,2 hexylene glycols For 1:1~5, both raw materials, which coordinate, has good antioxidation, and prevents bacteria breed, does not stimulate gently.
Chelating agent is EDETATE SODIUM, can chelate stabilized formulations, is not in situations such as product is layered.
The preservative of the present invention is that one or both of methyl hydroxybenzoate, Phenoxyethanol combine, its dosage≤0.5%.
The present invention can be produced using existing conventional Essence production method, and product meets national standard《QBT 2660-2004 toners》.
The hirudin of the present invention has following feature.
(a) autonomous directly infiltration, Transdermal absorption:The molecular weight of hirudin is only 7000 dalton, can be independently directly rapid Penetrate to the skin deep layer, is easily absorbed by Skin Cell.
(b) blood circulation is improved:Natural hirudin only needs external application independently to penetrate into blood microcirculation so as to reduce blood Viscosity, accelerate blood flowing speed, dredge capillary, improve blood vessel microcirculation, skin body of gland and pore is kept clear, promote Enter skin metabolism, nutritional ingredient necessary to be provided for skin, reduce moisture loss, maintain the normal physiological function of skin, Cell is obtained the nutrient of abundance, promote the self-regeneration of cell, make the pore that skin is fine and smooth, contraction is thick, especially to powder Thorn, acne, redness, facial pigmentation deposition, Skin indentation reparation, whitening have effect unique.Thus fundamentally solve all kinds of skins Skin problem, reach the purpose of blood beauty, skin cell is become health, clean, turgor, rich in life vigor so as to being in U.S. of existing health.
(c) nutrition skin:Hirudin is polypeptides matter.Polypeptide is by Amino acid profile but in different fourth protein Between material, it has the characteristic of protein, but simpler from matter than egg, and molecular weight is small, is easily absorbed by organisms, and hirudin activity Height, using micro with regard to its unique physiological action can be played.
(d) help and ooze, carry:Hirudin molecular weight is 7000 dalton, and it itself independently directly can not only be penetrated into rapidly Deep skin, easily absorbed by Skin Cell, also assist in the nutriment for being not easy to permeate and penetrate into deep skin, made up so as to play The due beauty and skin care effect of product.Promote skin blood circulation, accelerate metabolism, adhering to can light using a period of time skin It is sliding, it is delicate.Using to after on skin, layer of transparent, the elastic biological film of transparent gas can be quickly formed, improves the glossy of skin Degree, makes skin smooth fine and smooth, flexible.Simultaneously can anti-lipid peroxidation, effectively remove interior free yl, nutrition skin is light Change microgroove.
PCA- sodium is the natural moisture preserving agent in skin, is a kind of natural moisture preserving because of (Natural Moisturizing Factor, NMF).There is excellent hygroscopicity, give skin comfort and water moisture feeling, increase flexibility and elasticity.Even in highly concentrated Under degree, the stimulation to skin and eye mucosa is seldom, colorless and odorless, is stable at low temperature and high temperature, can be biodegradable rapidly.
Glycine betaine NMF green organic certification, osmotic protection, water balance is adjusted, mitigate the ultraviolet line loss of skin Wound, fibroblast vigor is stimulated, promote collagen synthesis, improved skin elasticity, effectively remove free radical, while flesh of releiving Skin, give skin care.
Configuration and hybrid technology of the preparation method of the present invention for routine, reference and the existing Essence technology of preparing of reference , do not elaborate herein.
Compared with prior art, the invention has the advantages that:
1st, the present invention hirudin of certain content and a variety of extracted form natural plant compositions are with the addition of in raw material components, respectively into Divide synergy so that the hirudin profit face moisturizing maintenance elite produced can promote active component effectively quickly to absorb, and be Skin cell provides a variety of nutritions, improves the glossy degree of skin, makes the smooth fine and smooth effectively removing interior free yl of skin, battalion Support glossy skin, desalinate microgroove, have moisturizing it is anti-ageing repair skin the effect of.
2nd, the leech cellulose content added in raw material of the present invention is controlled within 10%, can play its skin care, is controlled Or regulation skin aging process, damaged skin is protected, controls being produced into for product again while the effect of delay skin aging This.Because hirudin is expensive, dosage less effective at least, it is too high that dosage crosses at most cost.
3rd, the emollient used in the present invention is respectively provided with good amphipathic property, can reduce sticky sense, water profit skin And keep human body skin oil-water balance.The present invention is also to the glycerine of PEG/PPG/ polytetramethylene glycols 8/5/3, PEG/PPG-14/7 bis- simultaneously Proportioning during methyl ether, ceramide -3 are used in conjunction with each other optimizes so that the emollient of product is more preferable, moistens and makees With obvious.
4th, NMF of the present invention, hirudin and emollient can supplement skin in time while cleaning skin Skin nutrition, careful skin is moistened, gives skin gently soft and moist care.
Brief description of the drawings
Fig. 1 is the lost figure of moisture of skin;
Fig. 2 is product sensory figure.
Embodiment
Embodiments of the invention are described in detail below, so that advantages and features of the invention are easier to be understood, Apparent clearly defined so as to be made to protection scope of the present invention.
The hirudin profit face moisturizing maintenance Essence of the present invention can use existing conventional elite liquid and preparation method thereof, will stir Pot is cleaned up, and the solid constituent in raw material then is added into agitated kettle, maintains the temperature at 90 DEG C, mixing speed control exists 100r/min stirrings insulation 25 minutes, then opening cooling water makes temperature be reduced to less than 70 degree, then adds Sodium Hyaluronate etc. Pulvis raw material stirring and dissolving to it is transparent, without graininess, then open cooling water temperature to 45 DEG C, add extracted form natural plant composition, stir Mix uniformly.Temperature is down to 35~38 DEG C of filtering and dischargings, is detected after standing 24 hours, and it is small then to place into 8-10 DEG C of standing 48 When, the filling hirudin that can obtain is carried out after product is stable and moistens face moisturizing maintenance Essence.
Using above-mentioned preparation method prepare hirudin profit face moisturizing maintenance Essence, specific composition of raw materials for example table 1, table 2, Table 3 (unless otherwise instructed, refers both to mass ratio, surplus is water).
Table 1:
Table 2:
Table 3:
The hirudin profit face moisturizing maintenance Essence that the present invention is prepared meets national standard《QBT 2660-2004ization Adornment water》, provide it to consumer and tried out, and product is evaluated, evaluation table such as following table:
The consumer of table 4 is to skin-toning effects evaluation score of releiving
Note:The assessment result that consumer evaluation obtains.It is obviously improved effect:10 points best, and 0 point worst.
Assessment result shows that hirudin of the present invention profit face moisturizing maintenance elite can be brought to consumer and is full of damp elasticity, activation flesh The effect of skin.
Volunteer is to moistening moistening effect evaluation
Experiment number:30 (man 15, female 15), experimental period is 4 hours, by case study on implementation 1 and commercially available well-known production Product 1, commercially available hit product 2 under equal conditions test the improvement using rear skin, are surveyed with moisture of skin tester Amount, obtain the lost figure of moisture of skin, such as Fig. 1;And establish product sensory figure, such as Fig. 2.
According to assessment result, show that hirudin profit face moisturizing maintenance elite of the present invention has the anti-ageing skin lightening reparation of good moisturizing Effect is well more many than commercially available moisturizing essence effect.

Claims (10)

1. a kind of hirudin moistens face moisturizing maintenance Essence, it is characterised in that:It includes following component:5%~20% skin Conditioner;3~20% NMF;0.5%~10% hirudin;1%~8% emollient;Surplus is water.
2. hirudin according to claim 1 moistens face moisturizing maintenance Essence, it is characterised in that:It includes following component: 5%~10% skin conditioning agent;10~20% NMF;1%~5% hirudin;4%~6% emollient;Surplus For water.
3. hirudin according to claim 1 or 2 moistens face moisturizing maintenance Essence, it is characterised in that:Also include quality hundred Divide the antioxidant of ratio≤1%;Mass percent < 1% chelating agent;The preservative of mass percent≤1%.
4. hirudin according to claim 3 moistens face moisturizing maintenance Essence, it is characterised in that:The skin conditioning agent choosing Self asiatic extract, collagen, purslane extract, dipotassium glycyrrhizinate, peppermint leaf extract, Pelargonium roseum extract, hardship Join root extract, golden yellow camomile extract, aloe barbadensis Miller leaf extract, allantoin, hydroxy phenylpropionyl amine benzoic acid, nerve More than four kinds in acid amides -3, saccharomycete lysis thing are combined.
5. hirudin according to claim 3 moistens face moisturizing maintenance Essence, it is characterised in that:The NMF is selected from more First alcohols, ethoxy urea, DL- pyrrolidone sodium carboxylates (PCA-Na), glycine betaine, Sodium Hyaluronate and one kind in serine or Multiple combinations;The emollient be polyalcohols, the glycerine of PEG/PPG/ polytetramethylene glycols 8/5/3, PEG/PPG-14/7 dimethyl ethers, Three kinds of combination of the above in ceramide -3.
6. hirudin according to claim 4 moistens face moisturizing maintenance Essence, it is characterised in that:The hirudin and yeast The mass ratio of bacterium lysis thing is 1~5:1.
7. hirudin according to claim 5 moistens face moisturizing maintenance Essence, it is characterised in that:The polyalcohols include 1,2- hexylene glycol, 1,2- pentanediol, 1,3-PD and butanediol.
8. hirudin according to claim 5 moistens face moisturizing maintenance Essence, it is characterised in that:The poly- fourths of PEG/PPG/ The glycerine of glycol 8/5/3, PEG/PPG-14/7 dimethyl ethers, the mass ratio of ceramide -3 are 40~50:40~50:1.
9. hirudin according to claim 5 moistens face moisturizing maintenance elite, it is characterised in that:The antioxidant is to hydroxyl Benzoylformaldoxime;The chelating agent is EDETATE SODIUM, and the preservative is one or both of methyl hydroxybenzoate, Phenoxyethanol group Close, its dosage≤0.5%.
10. hirudin according to claim 9 moistens face moisturizing maintenance Essence, it is characterised in that:Parahydroxyacet-ophenone with The mass ratio of 1,2 hexylene glycols is 1:1~5.
CN201711371054.9A 2017-12-19 2017-12-19 A kind of hirudin moistens face moisturizing maintenance Essence Pending CN107854326A (en)

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Cited By (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN108403483A (en) * 2018-06-02 2018-08-17 杭州兰茜化妆品有限公司 It is a kind of element face frost and its preparation process
CN109260046A (en) * 2018-09-28 2019-01-25 重庆雅素生物科技有限公司 Hirudin repairs application, composition and the preparation method of skin red capillary or hormone face
CN109350564A (en) * 2018-11-02 2019-02-19 广州丽彦妆生物科技有限公司 A kind of resurrection is careless to repair stoste and preparation method thereof
CN109771324A (en) * 2019-03-29 2019-05-21 华熙生物科技股份有限公司 A kind of eye skin care compositions of hirudin and hyaluronic acid substance
CN110227050A (en) * 2019-07-26 2019-09-13 嘉兴言肌草生物技术有限公司 A kind of anti-aging maintenance sustained release Essence and the anti-aging Face-protecting mask using its preparation
CN110393690A (en) * 2019-08-07 2019-11-01 义乌市安彤医药科技有限公司 A kind of maintenance essence and preparation method thereof slowing down skin saccharification
CN110840811A (en) * 2019-11-15 2020-02-28 杭州倍荣生物科技有限公司 Repair essence
CN112057398A (en) * 2020-09-12 2020-12-11 荣鼎(广东)生物科技有限公司 Energy-emitting myoprotein liquid cosmetic and preparation method thereof

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CN108403483A (en) * 2018-06-02 2018-08-17 杭州兰茜化妆品有限公司 It is a kind of element face frost and its preparation process
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CN109771324B (en) * 2019-03-29 2021-12-10 华熙生物科技股份有限公司 An eye skin care composition containing hirudin and hyaluronic acid
CN110227050A (en) * 2019-07-26 2019-09-13 嘉兴言肌草生物技术有限公司 A kind of anti-aging maintenance sustained release Essence and the anti-aging Face-protecting mask using its preparation
CN110227050B (en) * 2019-07-26 2022-08-09 嘉兴言肌草生物技术有限公司 Anti-aging repairing slow-release essence and anti-aging repairing mask prepared from same
CN110393690A (en) * 2019-08-07 2019-11-01 义乌市安彤医药科技有限公司 A kind of maintenance essence and preparation method thereof slowing down skin saccharification
CN110840811A (en) * 2019-11-15 2020-02-28 杭州倍荣生物科技有限公司 Repair essence
CN112057398A (en) * 2020-09-12 2020-12-11 荣鼎(广东)生物科技有限公司 Energy-emitting myoprotein liquid cosmetic and preparation method thereof

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