CN1522689A - Leech extract cosmetics and method for making same - Google Patents

Leech extract cosmetics and method for making same Download PDF

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CN1522689A
CN1522689A CN 03140487 CN03140487A CN1522689A CN 1522689 A CN1522689 A CN 1522689A CN 03140487 CN03140487 CN 03140487 CN 03140487 A CN03140487 A CN 03140487A CN 1522689 A CN1522689 A CN 1522689A
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leech
cosmetics
extract
leech extract
oil
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CN 03140487
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CN1259034C (en )
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周维海
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周维海
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Abstract

The present invention discloses a face-beautifying cosmetic, it includes leech extract, oil, aliphatic ester, organic solvent, perfume, nutrient and refined water, and its preparation method includes the following steps: mixing oil, aliphatic ester, organic solvent and refined water in a certain proportion, heating to 60-90 deg.C to make them molten, cooling to room temperature and adding leech extract and proper quantity of essence, fully stirring them and uniformly mixing them so as to obtain the invented product with the functions of eliminating marks and freckle, removing zits, moistening skin, preventing skin senility and raising skin elasticity, etc.

Description

水蛭提取物美容化妆品及其制备方法 Cosmetic composition and preparation method leech extract

技术领域 FIELD

本发明涉及一种日用化工用品,具体的说是一种美容化妆品、特殊用途美容化妆品及其制备方法。 The present invention relates to a household chemical products, specifically a cosmetics, cosmetics for special purposes and its preparation method.

背景技术 Background technique

自古以来,女人对于美丽最大的愿望就是希望自己能拥有漂亮的脸及细腻、光滑的皮肤,于是,美容、美发、化妆,让肌肤呈现柔滑洁白细嫩的质感,成为几千年来女性谈论不完的话题和永远追求的目标,美容护肤化妆品也一直以来都是女性们最喜爱的商品。 Since ancient times, beautiful woman for his own greatest wish is to have a beautiful face and delicate, smooth skin, so, hairdressing, makeup, allow your skin smooth and white and delicate texture, has become for thousands of years women still talk about the topic and always our goal, skin care cosmetics, women who have always been the most favorite products. 为了达到美容目的,人们使用了各种各样的原料做成美容护肤品,如牛奶、胎盘素、蛋白、乳酸、各种维生素、各种中草药、过去有的甚至使用有毒害的重金属铅。 In order to achieve cosmetic purposes, people use a variety of skin care products made of raw materials such as milk, placenta, protein, lactic acid, vitamins, various herbs, past and some even use of toxic heavy metals lead.

近年来,随着科学技术的发展,特别是生物医药技术向化妆品制造领域中的渗透及应用,国际上许多医药及生物工程技术专家投身于美容化妆品的研究中,市场上也出现了琳琅满目的各种各样的美容护肤化妆品,公开出版物也刊登了许多美容护肤化妆品的生产方法和配方,如中国专利<申请号>92107760,<发明名称>鱼油美容化妆品及制备方法,化妆品的原料配方包括:十八醇、白油、尼泊金乙酯、硅油、单甘酯和水,并在其中加入了5-10%的鱼油,鱼油与其他原料配方同时加入到一起,进行混合、加热、搅拌、碾磨、乳化、冷却、灌装。 In recent years, with the development of science and technology, especially in the field of biomedical technology to join the cosmetics manufactured in the penetration and application of many pharmaceutical and biotechnology experts in the world of cosmetics research, the market also appeared in an array of various species variety of skin care cosmetics, publication also published a number of production methods and formulations skin care cosmetics, such as Chinese Patent & lt; application No. & gt; 92.10776 million, & lt; Title & gt; fish oil cosmetics and preparation, cosmetics feed formulation comprising: stearyl alcohol, white oil, ethyl paraben, silicone oils, monoglycerides and water, and adding 5-10% fish oil, fish oil and other raw materials added to the formulation simultaneously with, mixing, heating, stirring, milling, emulsification, cooling, filling. 中国专利<申请号>95109796<发明名称>油松花粉美容品,它是由油松花粉浓缩液、硬脂酸、甘油、三乙醇胺、羊毛脂、精制水、防腐剂、香精组成。 Chinese Patent & lt; Application No. & gt; 95,109,796 & lt; Title & gt; of Pollen beauty products, which is composed of Pollen concentrate, stearic acid, glycerol, triethanolamine, lanolin, purified water, a preservative, a fragrance composition. 各组分配比为(重量百分比):花粉浓缩液10-20%,硬脂酸15-20%,甘油2-3%,三乙醇胺0.8-1%,羊毛脂1.5-2.5%,防腐剂0.5-1%,香精0.5-1%,精制水为余量。 Each group distribution ratio (weight percentage): 10-20% pollen concentrate, 15-20% stearic, 2-3% glycerol, triethanolamine 0.8-1%, 1.5-2.5% lanolin, preservative 0.5 1%, 0.5% flavor, purified water balance. 花粉浓缩液由精制花粉经浸泡、破壁、离心分离所得的花粉汁再经真空浓缩而制成的。 Pollen pollen concentrate was purified by a soaking, broken, resulting in centrifugal separation and then concentrated in vacuo pollen juice made of. 本发明具有绿色、天然、营养、保健功能,美容效果较好。 The invention has the green, natural, nutrition, health function, better cosmetic results. 中国专利<申请号>92114173,<发明名称>去斑霜及其制造方法,它的组分及各成分的比例为:抗坏血酸苯酯3~8%、硬脂酸10%、甘油5%、十八醇1%、二氧化钛2%、水杨酸0.5%、单硬脂酸甘油酯1%、酒精∶二甲亚砜3∶1混合溶剂77.5~72.5%。 Chinese Patent & lt; Application No. & gt; 92,114,173, & lt; Title & gt; spot cream and its manufacturing method, the ratio of its components and each component is: ascorbic acid phenyl ester 3 to 8%, 10% stearic acid, glycerol 5%, 1% stearyl alcohol, 2% titanium dioxide, 0.5% salicylic acid, 1% glycerol monostearate, alcohol: a mixed solvent of dimethylsulfoxide 3:1 77.5 ~ 72.5%. 该产品安全无毒,无任何副作用,去斑能力强,适用范围广,涂用2~3个月,即可消除面部影响美容的色素障碍性斑块,尤其对激光手术后色素沉着有极好的去斑增白作用。 The product is safe non-toxic, without any side effects, speckle strong ability, wide application, coated with 2 to 3 months, you can eliminate facial pigmentation disorders affect the beauty of plaques, especially for hyperpigmentation after laser surgery excellent speckle whitening effect. 中国专利<申请号>93115858,<发明名称>月见草油润肤露配方及制作方法,采用一定配比的月见草油、维生素E,硬脂酸、十八醇、单硬脂酸甘油脂、香精、十二醚基氮唑酮、三乙醇胺、液体石蜡等经加温、搅拌加工制成它具有软化皮肤毛细血管、皮肤角蛋白的作用。 Chinese Patent & lt; Application No. & gt; 93,115,858, & lt; Title & gt; evening primrose oil lotion formulations and production methods, using a certain ratio of evening primrose oil, vitamin E, stearic acid, stearyl alcohol, mono glyceryl stearate, flavor, dodecyl ether ketone triazole group, triethanolamine, liquid paraffin by heating, stir processing has made it softens skin capillary action, skin keratin.

从公开文献看,目前生产的美容化妆品原料,主要由油脂、脂肪酸或脂肪酸酯、有机溶剂、香料、营养素、有一定功能的药物等成分组成,有的还加入了一些生物活性物质,使化妆品能够维护皮肤的正常生理功能,并且能够促进细胞新陈代谢、控制或调节皮肤老化进程,对延缓皮肤老化,保护受损皮肤。 See the publication, the current production of cosmetics ingredients raw materials, mainly oil, fatty acids or fatty acid esters, organic solvents, perfumes, nutrients, drugs have a certain function, etc., and some also added a number of biologically active substances, the cosmetic It can maintain the normal physiological function of the skin, and can promote cell metabolism, control or regulate the skin aging process, to delay skin aging, protect the damaged skin.

另外,在研究和生产常规的美容化妆品的过程中,人们也了解到,有的人除了需要美容护肤外,也需要对色癍、痤疮进行治疗,于是,公开文献也报道了一些治疗色癍、痤疮的化妆品,如中国专利<申请号>02144666,<发明名称>粉刺霜,本发明的美容化妆品—粉刺霜由乳糖酸红霉素10~20份、甲硝唑150~250份、基质为A、B两种组份;基质A组份采用:十六醇、白油、羊硬脂酸甘油、聚氧乙烯20单位、防腐剂适量;B组份采用:甘油、蒸馏水、C维A酸、E维、香料适量。 In addition, the research and production of conventional cosmetics in the process, it is also learned that some people in addition to skin care, but also the need for color plaques, acne treatment, then, publications have reported some color therapy Ban, acne cosmetics, Chinese Patent & lt; application No. & gt; 02,144,666, & lt; Title & gt; acne creams, cosmetics of the present invention - acne cream 10 to 20 parts of erythromycin lactobionate, metronidazole 150 to 250 parts by , the matrix A, B, both components; use of a matrix A component: cetyl alcohol, white oil, sheep glycerol stearate, polyoxyethylene 20 units, a preservative amount; component B adopted: glycerine, distilled water, C Vitamin A acid, E-dimensional, spices amount. 本发明经临床应用对葡萄球菌、链球菌感染,炭疽杆菌、厌氧菌、痤疮丙酸杆菌等引起的皮肤感染病原菌有良好的抗菌活性。 Clinical application of the present invention of pathogens good antibacterial activity against the skin staphylococcus, streptococcus infection, Bacillus anthracis, anaerobic bacteria, Propionibacterium acnes caused. 能抑制杀灭痤疮丙酸杆菌及其它一些敏感菌种,减少脂肪酶的生成。 Can inhibit killing P. acnes and other sensitive species, reducing the generation of lipase. 对脸部痤疮、脂溢性皮炎、酒渣鼻及其它多种细菌性皮肤感染的治疗和预防有独特的疗效。 Facial acne, seborrheic dermatitis, rosacea and many other bacterial skin infection treatment and prevention have a unique effect. 其消除痤疮、脂溢性皮炎的作用是基于容化妆品中包含有抗生素和杀菌剂,使用后能抗击痤疮棒状杆菌,消除毛囊皮脂腺管内的炎症,使之恢复皮肤的健康。 Which eliminates acne, seborrheic dermatitis is based on the role of receiving a cosmetic contains antibiotics and fungicides, can be used to combat the Corynebacterium acne, inflammation of the pilosebaceous eliminating pipe, so as to restore healthy skin.

技术内容本发明人长期从事生物活性物质研究工作,对目前利用生物活性物质进行美容护肤有一定的了解,认识到一些氨基酸、多肽类物质、海洋生物、壳聚糖、水蛭提取物、中药提取物在一定程度上对人体皮肤有着延缓衰老和调理人体新陈代谢的作用,还有抗皱、美白、消炎、消肿、杀菌的功能,所以本发明人特别对多肽类物质、海洋生物、壳聚糖、水蛭提取物进行了专门对比试验,发现水蛭提取物具有祛斑、祛痘、润肤、嫩肤、美白、预防皮肤衰老、增强皮肤弹性之功效,所以以水蛭提取物为主要原料,试制了一种美容化妆品,取得了初步的成效。 The technical content of the present inventors engaged in research of biologically active substances, skin care for ongoing use of biologically active substances have a certain understanding, recognizing that some amino acids, peptide material, marine life, chitosan, leech extract, herbal extract to a certain extent to human skin with anti-aging and conditioning role of human metabolism, as well as anti-wrinkle, whitening, inflammation, swelling, sterilization function, so the present invention is particularly for peptide material, marine life, chitosan, leech extract special comparative tests, it was found leech extracts freckle, acne, skin, skin rejuvenation, whitening, skin aging prevention, enhanced elasticity of the skin effect, so to leech extract as the main raw material, a cosmetic trial cosmetics, achieved initial results.

本发明的技术方案是这样实现的:美容护肤化妆品包括水蛭提取物、油脂、脂肪酸酯、有机溶剂、香料、营养素,其原料的主要成分和重量百分含量如下:水蛭提取物 0.1-20%油脂 1-15%脂肪酸酯 1-25%有机溶剂 1-8%香料 0.1-1%精制水 余量其它营养成分,根据实际情况加入。 Aspect of the present invention is implemented as follows: skin care cosmetics include leech extract, fat, fatty acid esters, organic solvents, perfumes, nutrients, and the main component of the weight percentage of raw materials as follows: 0.1 to 20% leech extract oil fatty acid ester 1-25% 1-15% organic solvent 1-8% perfume 0.1-1% purified water balance other nutrients were added according to the actual situation.

特殊医药物质,根据实际情况加入。 Special medicinal substances added according to the actual situation.

以上所述的水蛭提取物以天然水蛭素为主,是从水蛭干体提取的物质或者从水蛭中提取唾液腺分泌物粗品进行深加工,具体方法是首先从水蛭活体、干体中提取天然水蛭、透明质酸酶等多种生物活性物质,然后经离心除杂、层析和灭菌过滤后,取离心分离后的上清液,用无菌蒸馏水调配后,得到水蛭提取物。 The above-described leech extract natural hirudin based, is extracted salivary secretions of crude product for further processing from the leech from the substance leech dry material extracted or specific method is to first extract natural hirudin from leeches living body, dry body, transparent hyaluronic acid enzymes and various biologically active substances, and purify by centrifugation, chromatography and sterile filtration, the supernatant after centrifugation, after formulation with sterile distilled water to give a leech extract.

具体从水蛭中提取唾液腺分泌物的方法可以按本发明人申请的中国专利《菲牛蛭的养殖方法及水蛭素的提取方法》介绍的提取方法进行,以下再复述该方法:1、其中分离和纯化的方法是:将从上述水蛭体内提取出的唾液腺分泌物提取液干水蛭提取物粗品中加4倍置冰箱中预冷的含水15%的丙酮,搅拌后置冰箱中过夜,吸出上清丙酮并离心,在沉淀中加入预冷的三氯乙酸使其溶解,离心除去残渣,待上样进行柱层析。 "Extraction manillensis farming methods hirudin" DETAILED extracted from the salivary secretions of leeches of the present invention may be by Chinese patent application describes extraction method is performed, and then repeat this method the following: 1, and wherein the separation purification methods are: extracted from the salivary secretions of the leech body extract of leech dry crude extracts was added 4 times in refrigerator-cold 15% aqueous acetone, followed by stirring overnight in refrigerator, the supernatant was aspirated acetone and centrifuged in a prechilled trichloroacetic acid to dissolve the precipitate, the residue was removed by centrifugation, the sample to be subjected to column chromatography.

2、阴离子交换柱层析的方法是:取适量DEAE-C加蒸馏水使其膨胀,按常规方法依次用NaOH-NaCl混合液、HCl及NaOH-NaCl混合液各浸泡30分后用蒸馏水洗涤至中性。 2, the method is anion exchange column chromatography: DEAE-C was added an appropriate amount of distilled water to inflate sequentially with NaOH-NaCl mixture in a conventional manner, HCl and NaOH-NaCl mixture was washed with distilled water after each soaking 30 minutes to sex. 装柱至所需高度,用柠檬酸-柠檬酸钠缓冲液平衡,5ml的唾液腺分泌物浓缩液或上述三氯乙酸溶液上样进行梯度洗脱并用记录仪绘出洗脱曲线,分段收集洗脱液,经检测,将有活力部分集中于透析袋中用甘油浓缩,再测总蛋白含量,继续以下的柱层析。 Packed to the desired height, citric acid - sodium citrate buffer equilibrium, salivary secretions 5ml sample was concentrated on the gradient elution liquid or trichloroacetic acid solution and the above-described recording apparatus depicted in the elution curve, wash collected segment deliquored, after testing, the dynamic part concentrated in a dialysis bag with concentrated glycerin, and then measuring the total protein content, continue with the following column chromatography.

3、凝胶过滤柱层析的方法是:取适量的加蒸馏水浸泡4h,按常规方法用NaOH-NaCl混合液浸泡0.5h,抽滤除去碱液并用蒸馏水洗涤至中性,加热煮沸除去气泡。 3, gel filtration column chromatography methods are: Apply soaked in distilled water is added 4h, in a conventional manner with NaOH-NaCl mixture soaked 0.5h, filtered off with suction and washed with distilled water to remove alkaline to neutral, heated to boiling to remove bubbles. 装柱至所需高度,用TRIS-HCl-NaCl缓冲液平衡,将上述有活力洗脱液的浓缩液上样、洗脱并用记录仪绘出洗脱曲线,分段收集洗脱液,分别检测活力,将有活力部分集中于透析袋中用甘油浓缩。 Packed to the desired height, with the TRIS-HCl-NaCl buffer equilibration, the samples have the above activity eluate was concentrated, and eluted with the elution curve plotted recorder, segment eluate were detected activity, the dynamic part concentrated in a dialysis bag and concentrated glycerol. 再则活力后,待用DU-70贝克曼分光光度计在200nm至400nm波长范围内扫描。 Furthermore the activity, stand Beckman DU-70 spectrophotometer scanning the 200nm to 400nm wavelength range.

以上所述的油脂包括无毒无害的矿物油、动物油、植物油,如甘油、橄榄油、白油、凡士林、石蜡油、月桂油、杏仁油等,及其它们之间的混合物。 The above fat or oil comprises a non-toxic mineral oils, animal oils, vegetable oils, such as glycerol, olive oil, white oil, petrolatum, paraffin oil, bay oil, almond oil, and mixtures between them.

以上所述的脂肪酸酯包括甘油三硬脂酸酯、甘油单硬脂酸酯、曲酸单硬脂酸酯、羊毛酯等,可以选用单组分或混合物。 The above fatty acid esters include glycerol tristearate, glycerol monostearate, kojic acid monostearate, lanolin and the like, may use a single component or a mixture thereof.

以上所述的有机溶剂包括乙醇、十六醇、十八醇、丙二醇等。 The above organic solvents include alcohol, cetyl alcohol, stearyl alcohol, propylene glycol, and the like.

以上所述的香料为医药或食品中常用的植物香料或动物香料、混合香料。 The above-described pharmaceutical or food flavor is a commonly used animal or botanical flavors perfume, mixed perfume.

以上所述的其它营养成分包括维生素类、珍珠水解液、氨基酸、多肽类物质、牛奶、胎盘素、蛋白、乳酸、各种微量元素;所述的特殊医药物质包括各种中草药、西药、如消炎抗菌药、防皱祛斑药等。 The above-described other nutrients include vitamins, pearl hydrolyzate, amino acid, peptide material, milk, placenta, protein, lactic acid, trace elements; the specific substances include various herbal medicine, medicine, such as anti-inflammatory antibiotics, anti-wrinkle cream medicine.

以上所述的精制水为重蒸馏水、纯净水,或蒸馏后再用离子交换法制取。 The above-described purified water re-distilled water, purified water, or distillation and then with ion exchanged Preparation.

以上所述的美容化妆品可以是膏状体产品或液体状产品或嗜哩状产品。 Above may be the cosmetics product into paste or liquid product or product Shili like.

以下介绍本发明的美容化妆品生产方法:一、膏状体美容化妆品生产方法先按一定比例的油类、脂肪酸酯、有机溶剂和适量的精制水混合,加热至60-90℃,使其融合,直至显出柔和的膏体,冷却到50℃时边搅拌边加入其它营养成分或特殊医药物质,待其冷却到室温时再加入水蛭提取物和适量的香精,然后充分搅拌使之完全均匀得到产品。 The following describes the method of producing cosmetics according to the present invention: a method for producing pasty body cosmetics press a certain percentage of oil, a fatty acid ester, an organic solvent and an appropriate amount of purified water were mixed and heated to 60-90 deg.] C, which are fused until showing a soft paste, with stirring upon cooling to 50 deg.] C is added with other nutrients or special pharmaceutical substance, and then add an appropriate amount of leech extract flavor when let it cool to room temperature and then sufficiently stirred to obtain completely uniform product.

二、液体状美容护肤化妆品生产方法把一定比例的油类、脂肪酸酯、有机溶剂和适量的精制水混合后,加热至60-90℃,使其融合,待其冷却到室温时再加入水蛭提取物和适量的香精,然后充分搅拌使之完全均匀得到产品。 Second, the liquid cosmetic skin care method for producing a certain percentage of oil, after mixing the organic solvent purified water appropriate amount of fatty acid ester and heated to 60-90 deg.] C, which are fused, was added when the leech let it cool to room temperature extract and an appropriate amount of flavor, and then sufficiently stirred to obtain completely uniform product.

三、嗜哩状美容化妆品生产方法嗜哩状美容化妆品生产方法是先把基质做成嗜哩状,然后在室温下添加一定数量的水蛭提取物,然后充分搅拌使之完全均匀得到产品。 Third, the production method of producing cosmetics Shi Li Shi Li-like shaped first substrate is made of cosmetics Shi Li shape, and then add a certain amount of leech extract at room temperature and then sufficiently stirred to obtain completely uniform product.

本发明的实质性特点和显著的进步是:水蛭提取物美容化妆品是采用名贵中药水蛭,借助现代生物科技技术,从天然生物中提取得到水蛭提取物、透明质酸酶等多种生物活性物质经精制而成,具有祛斑、祛痘、润肤、嫩肤、美白、预防皮肤衰老、增强皮肤弹性之功效,为高效、绿色美容护肤品。 And essential characteristics of the present invention is a significant advance: leech extracts is the use of cosmetics leech valuable medicine, the use of modern biotechnology techniques, obtained from natural biological extract of leech extract, hyaluronic acid by enzymes and biologically active substances refined, with freckle, acne, skin, skin rejuvenation, whitening, prevent skin aging, enhance skin elasticity effect of, for the efficient, green beauty skin care products.

科学研究表明,生物活性物质是皮肤护理的最佳物质,它不但能够维护皮肤的正常生理功能,而且能够促进细胞新陈代谢,能够控制或调节皮肤老化进程,对延缓皮肤老化,保护受损皮肤具有重要作用。 Scientific research shows that the biologically active substance in skin care is the best material, it will not only be able to maintain the normal physiological function of the skin, and can promote cell metabolism, to control or regulate the skin aging process, to delay skin aging, damaged skin protection is important effect. 水蛭提取物具有活血化淤、增加皮肤弹性、延缓衰老和调理人体新陈代谢的作用,还有抗皱、美白、消炎、消肿、杀菌的功能,适合于任何年龄的人群使用。 Leech extracts with blood circulation, increase skin elasticity, anti-aging and conditioning role of human metabolism, as well as anti-wrinkle, whitening, inflammation, swelling, sterilization function, suitable for people of any age to use.

另外,水蛭提取物不象以往的美容产品需要依靠其它助渗剂的辅助作用渗透皮肤,由于它分子量小,本身能直接渗透皮肤深层,加速细胞新陈代谢,疏通毛细血管,改善面部微循环,抑制和减少黑色素细胞的生长,具有消退面部色素沉着的作用。 Further, unlike the conventional leech extract cosmetic products rely on other supporting role of skin penetration aids penetration, because of its small molecular weight, can directly penetrate deep skin itself, accelerate cell metabolism, and clear the blood vessels, improving microcirculation of the face, and inhibition reducing the growth of melanoma cells, having a face pigmentation fade effect. 经常使用水蛭提取物不但能使皮肤细腻、光滑、美白,还具有特别优异的抗衰老作用,无任何毒副作用等特点。 Leech extracts are often used not only to make the skin smooth, smooth, white, also has a particularly excellent anti-aging effects, no side effects and so on.

本发明的美容化妆品最重要的特点是能够治疗痤疮。 The most important feature of the cosmetics of the present invention is able to treat acne. 痤疮是一种常见病和多发病,普遍在青年人中出现,又俗称“青春痘”,本病一般常发生于脸、胸、背部,初起为位于毛囊口的白头粉刺或黑头粉刺,并可挤出黄白色半透明脂栓,以后可出现炎性红色丘疹、胞疮、结节、脓肿、囊肿等皮损,皮损消退后可留有暂时性色素沉着或小坑凹状疤痕,由于青年人尤其其注重容貌,脸上产生痤疮时极为苦恼,有的影响了工作学习,甚至羞于见人,为了治疗这种疾病,目前医院也只用一些消炎药,治疗效果不好,有的城市设立美容店,用一些中药或有机药物进行外用,但也只对不严重的粉刺起到一些作用,过1-2天又会复发。 Acne is a common and frequently-occurring disease, the prevalence among young people, also commonly known as "acne", the disease often occurs generally in the face, chest, back, beginning as a whitehead or blackhead is located in the mouth of the hair follicle, and yellow-white translucent extrudable aliphatic bolt, can occur after an inflammatory red papules, sores cells, nodules, abscesses, cysts and other skin lesions, skin lesions subsided after leaving temporary pigmentation or scar small crater-like, since the youth people, especially its emphasis on appearance, extremely distressed when produce acne on the face, and some affect the work and study, even ashamed to see people, to treat the disease, the hospital only a few anti-inflammatory drugs, bad treatment, some cities set up a beauty shop, a topical use some organic medicine or drugs, but also play some role in not only severe acne, over 1-2 days will relapse. 本发明的美容化妆品由于加入了水蛭提取物,水蛭提取物的主要成分是天然水蛭素,它是存在于吸血水蛭比如菲牛蛭(俗称金边蚂蟥)唾液腺里的一种生物活性物质,具有其它生物酶所没有的独特活性。 Cosmetics of the present invention due to the addition of leech extract, the main component is a natural extract of leech hirudin, which is present in such blood-sucking leeches manillensis (commonly known as rim leech) salivary glands in a biologically active substance, with other organisms the enzyme activity is not unique. 1904年被发现,经科学研究证实,它是由65个氨基酸组成的低分子量多肽,对凝血酶有极强的抑制作用,是公认的迄今为止世界已知抗凝血物质中最强的抗凝血酶物质,扩张血管、增加血液循环的作用十分显著。 Was discovered in 1904, the research confirmed that it is a low molecular weight polypeptide consisting of 65 amino acids, have a strong inhibition of thrombin, a substance is recognized by far the world's known anticoagulant strongest anticoagulation thrombin substance, dilate blood vessels, increases blood circulation is very significant. 天然水蛭素之所以被称为世界已知物质中最强的抗凝血酶物质,不但由于它所含有的生物活性成分的活性特别强,还因为它是一种低分子多肽,其分子量仅为7000,比起通常分子量为几万至十几万的其它蛋白质等生物活性物质要低得多,因而表现出非凡的渗透能力。 Natural hirudin is known as the world's strongest materials known antithrombin substances, not only due to the biological activity of the active ingredient it contains particularly strong, but also because it is a low molecular peptide having a molecular weight of only 7000, other than the usual molecular weight of tens of thousands of ten thousands of proteins and other biologically active substances is much lower, and thus demonstrated extraordinary ability to penetrate. 它不象以往的美容产品需要依靠其它助渗剂的辅助作用渗透皮肤,它本身能直接渗透皮肤深层,加速细胞新陈代谢,疏通毛细血管,改善面部微循环,抑制和减少黑色素细胞的生长,具有消炎、消肿、消退面部色素沉着的作用,尤其是对粉刺、痤疮及细腻皮肤、收缩毛孔、增白防晒具有独特效果。 It is not like the conventional cosmetic products rely on secondary effects of other penetration aids penetration of the skin, which itself can directly penetrate deep skin, accelerate cell metabolism, and clear the blood vessels, improving microcirculation of the face, and reduce the growth inhibition of melanoma cells, has anti-inflammatory , swelling, faded effect facial pigmentation calm, especially for acne, acne and delicate skin, shrink pores, whitening sunscreen has a unique effect. 有透明质酸酶,具有活血化淤的性质,能软化皮肤,强化细胞活力,刺激上皮细胞的分裂,加速皮肤细胞的再生,促进伤口的愈合,所以对治疗痤疮有较好的疗效。 There hyaluronidase has a property of blood stasis, to soften the skin, to strengthen the cell viability, stimulating division of epithelial cells, skin cells accelerated regeneration, wound healing, it has a good effect on the treatment of acne.

具体实施方式 detailed description

实施例1把甘油(5%)、甘油三硬脂酸酯(15%)、甘油单硬脂酸酯(12%)、维生素C(1%)、珍珠液(5%)、十六醇(4%)和适量的精制水混合后,加热至80-90℃,使其融合,直至显出柔和的膏体,待其冷却到30℃时再加入20%的水蛭提取物,然后充分搅拌使之完全均匀即可。 Example 1 Glycerin (5%), glycerol tristearate (15%), glyceryl monostearate (12%), vitamin C (1%), pearl solution (5%), cetyl alcohol ( 4%) and a suitable amount of refined water, mixed and heated to 80-90 deg.] C, which are fused, until the show soft paste, let it cool to 30 deg.] C was added 20% when leech extract, and then sufficiently stirred completely evenly.

实施例2把甘油(5%)、甘油三硬脂酸酯(8%)、甘油单硬脂酸酯(6%)、石蜡(4%)、十六醇(4%)和适量的精制水混合后,加热至80-90℃,使其融合,直至显出柔和的膏体,待其冷却到30℃时再加入8%的水蛭提取物和适量的香精,然后充分搅拌使之完全均匀即可。 Glyceryl tristearate (8%), glyceryl monostearate (6%), paraffin wax (4%), cetyl alcohol (4%) and an appropriate amount of purified water Example 2 Glycerin (5%), after the mixture was heated to 80-90 deg.] C, which are fused, until the show soft paste, let it cool to 30 deg.] C was added 8% of extract of leech and when an appropriate amount of flavor, and then sufficiently stirred to make completely uniform i.e. can.

实施例3把甘油(5%)、白油(15%)、曲酸单硬脂酸酯(2%)、硬脂酸10%、羊毛酯(2%)、无水亚硫酸钠(1%)、十二烷硫酸钠(0.1%)和适量的精制水混合后,加热至80-90℃,使其融合,直至显出柔和的膏体,冷却到50℃时边搅拌边加入芦荟提取液,待其冷却到30℃时再加入0.1%的水蛭提取物,然后充分搅拌使之完全均匀即可。 Embodiment Example 3 Glycerol (5%), white oil (15%), kojic acid monostearate (2%), 10% stearic acid, lanolin (2%), anhydrous sodium sulfite (1%), sodium dodecyl sulfate (0.1%) and a suitable amount of refined water, mixed and heated to 80-90 deg.] C, which are fused, until a soft paste show, stirring cooling to 50 deg.] C while adding aloe extract to be it was cooled at 30 ℃ was added to 0.1% of extract of leech and then sufficiently stirred to make it completely evenly.

实施例4把凡士林(10%)、羊毛酯(5%)、甘油单硬脂酸酯(12%)、丙二醇(4%)、聚乙二醇200(30)%、液体石蜡(4%)和适量的精制水混合后,加热至80-90℃,使其融合,直至显出柔和的膏体,待其冷却到30℃时再加入12%的水蛭提取物,然后充分搅拌使之完全均匀即可。 Example 4 vaseline (10%), lanolin (5%), glyceryl monostearate (12%), propylene glycol (4%), polyethylene glycol 200 (30)%, liquid paraffin (4%) after mixing and an appropriate amount of purified water was heated to 80-90 deg.] C, which are fused, until the show soft paste, let it cool to 30 deg.] C was added 12% when leech extract, and then sufficiently stirred and completely uniform It can be.

实施例5把甘油(5%)、杏仁油(2%)、甘油三硬脂酸酯(5%)、甘油单硬脂酸酯(3%)、维生素C(1%)、乙醇(3%)、氨基酸(5%)、水杨酸(0.5%)和适量的精制水混合后,加热至60-70℃,使其融合,待其冷却到30℃时再加入12%的水蛭提取物,然后充分搅拌使之完全均匀即可。 Example 5 Glycerin (5%), almond oil (2%), glycerol tristearate (5%), glyceryl monostearate (3%), vitamin C (1%), ethanol (3% ), the amino acid (5%), the acid (0.5%) and a suitable amount of purified water, mixed and heated to 60-70 deg.] C, which are fused, to let it cool at 30 ℃ added 12% leech extract, and then sufficiently stirred to completely evenly.

实施例6把甘油(5%)、甘油三硬脂酸酯(5%)、芦荟提取液(5%)、乙醇(5%)、氨基酸(15%)、水杨酸(0.5%)和适量的精制水混合后,加热至60-70℃,使其融合,待其冷却到30℃时再加入2%的水蛭提取物,然后充分搅拌使之完全均匀即可。 Example 6 Glycerin (5%), glyceryl tristearate (5%), Aloe extract (5%), ethanol (5%), amino acids (15%), salicylic acid (0.5%) and appropriate amounts after mixing the purified water and heated to 60-70 deg.] C, which are fused, until cooling to 30 deg.] C was added 2% of leech extract, and then sufficiently stirred to make it completely evenly.

实施例7把甘油(5%)、橄榄油(3%)、人参提取液(1%)、甘油三硬脂酸酯(5%)、甘油单硬脂酸酯(3%)、维生素C(1%)、羊胎盘液、氨基酸(5%)和适量的精制水混合后,加热至60-70℃,使其融合,待其冷却到30℃时再加入4%的水蛭提取物和适量的香精,然后充分搅拌使之完全均匀即可。 Example 7 Glycerin embodiment (5%), olive oil (3%), ginseng extract (1%), glycerol tristearate (5%), glyceryl monostearate (3%), vitamin C ( 1%), sheep placenta solution, the purified water mixed acid (5%) and the amount of heated to 60-70 deg.] C, which are fused, was added 4% of the leech extract, and when the amount of let it cool to 30 deg.] C flavor, then thoroughly stirred to completely evenly.

实施例8把甘油(5%)、甘油三硬脂酸酯(5%)、甘油单硬脂酸酯(3%)、维生素C(1%)、氨基酸(5%)、薰衣草(5%)、香薰精华油(1%)和适量的精制水混合后,加热至60-70℃,使其融合,待其冷却到30℃时再加入8%的水蛭提取物,然后充分搅拌使之完全均匀即可。 Example 8 Glycerin (5%), glyceryl tristearate (5%), glyceryl monostearate (3%), vitamin C (1%), amino acids (5%), lavender (5%) aromatherapy essential oil (1%) and a suitable amount of refined water, mixed and heated to 60-70 deg.] C, which are fused, let it cool to 30 deg.] C was added 8% when leech extract, and then sufficiently stirred and completely uniform It can be.

本发明产品的的美容护肤效果:应用实施例1:陈**,女,25岁,因16岁起脸上长满痤疮,皮肤粗糙,经多种中西药治疗,几年一直未好,很苦恼,后使用本发明的美容护肤产品,一天后便有效果,三天痤疮去除30%,一周基本消除,且不留任何痕印。 Beauty skin care products according to the invention: Application Example 1: ** Chen, female, 25 years old, due to the age of 16 face covered with acne, rough skin, through a variety of Chinese and Western medicine treatment, a few years has not been good, very distress, the use of skin care products of the present invention, a day after effective three days to remove 30% of acne, a week basically eliminated, without leaving any marks printed.

应用实施例2:张**,女,26岁,原来脸部皮肤比较粗糙,使用本发明的美容护肤产品,一周后便有效果,皮肤变得细腻、光滑。 Application Example 2: Zhang **, female, 26 years old, had a rough skin of the face, the use of skin care products of the present invention, effective after one week, the skin becomes fine and smooth.

应用实施例3:李**,男,65岁,原来脸部长有许多老人斑,曾使用过数种祛斑霜,均无明显的效果,在使用本发明的美容祛斑产品,约10天后老人斑便开始淡化。 Application Example 3: Lee **, M, 65 years old, former minister faces many age spots, had used Guoshuo kinds freckle cream, no significant effect, in the present invention is used beauty cream product, about 10 days old spot began to fade.

应用实施例4:刘**,男,28岁,因长期在高速公路上上班工作,经常暴晒在太阳下,因此皮肤比较黑,在使用使用本发明的美容护肤产品,一周后便有效果,皮肤变得细腻、光滑和美白。 Application Example 4: Liu **, M, 28 years old, due to long-term work on the highway work, often in the sun, so the skin is black, use skin care products using the present invention, a week after effective, the skin becomes delicate, smooth and white.

Claims (10)

  1. 1.一种水蛭提取物美容化妆品,其特征在于:该美容化妆品包括水蛭提取物、油脂、脂肪酸酯、有机溶剂、香料、营养素,其原料的主要成分和重量百分含量如下:水蛭提取物 0.1-20%油脂 1-15%脂肪酸酯 1-25%有机溶剂 1-8%香料 0.1-1%精制水 余量 A leech extract cosmetics, characterized in that: the cosmetics comprising a leech extract, fat, fatty acid esters, organic solvents, perfumes, nutrients, and the main component of the raw material weight percentage as follows: leech extract 0.1-20% oil fatty acid ester 1-25% 1-15% organic solvent 1-8% perfume 0.1-1% purified water balance
  2. 2.根据权利要求1所述水蛭提取物美容化妆品,其特征在于:所述的水蛭提取物以天然水蛭素为主,是从水蛭干体提取的物质或者从水蛭中提取出的唾液腺分泌物粗品进行深加工,具体方法是首先从水蛭活体、干体中提取天然水蛭、透明质酸酶等多种生物活性物质,然后经离心除杂、层析和灭菌过滤后,取离心分离后的上清液,用无菌蒸馏水调配后,得到水蛭提取物。 1 according to the leech extract cosmetics as claimed in claim wherein: said leech extract natural hirudin based, is extracted from the material body or a dry leech extracted from the leech salivary gland secretion crude further processing, the specific method is first extracted from the leech Hirudo natural living, dry body, hyaluronidase enzymes bioactive substances, and purify by centrifugation, chromatography and sterile filtration, the supernatant after centrifugation solution, after formulation with sterile distilled water to give a leech extract.
  3. 3.根据权利要求1所述水蛭提取物美容化妆品,其特征在于:所述的油脂包括无毒无害的矿物油、动物油、植物油,选自甘油、橄榄油、白油、凡士林、石蜡油、月桂油、杏仁油及其它们之间的混合物。 3. The method of claim 1 cosmetics leech extract, wherein: said grease comprises a non-toxic mineral oils, animal oils, vegetable oils, selected from glycerol, olive oil, white oil, petrolatum, paraffin oil, bay oil, almond oil and mixtures between them.
  4. 4.根据权利要求1所述水蛭提取物美容化妆品,其特征在于:所述的脂肪酸酯包括甘油三硬脂酸酯、甘油单硬脂酸酯、曲酸单硬脂酸酯、羊毛酯等,可以选用单组分或混合物。 4. The method of claim 1 leech extract cosmetics, characterized in that: the fatty acid esters include esters of glycerol tristearate, glyceryl monostearate, kojic acid monostearate, lanolin and the like , you can use a single component or a mixture thereof.
  5. 5.根据权利要求1所述水蛭提取物美容化妆品,其特征在于:所述的有机溶剂选用乙醇、十六醇、十八醇、丙二醇。 5. The method of claim 1 leech extract cosmetics, characterized in that: said organic solvent is selected alcohol, cetyl alcohol, stearyl alcohol, propylene glycol.
  6. 6.根据权利要求1所述水蛭提取物美容化妆品,其特征在于:所述的香料为医药或食品中常用的植物香料或动物香料、混合香料。 According to claim 1 leech extract cosmetics, characterized in that: said fragrance is a pharmaceutical or food animals or plants commonly used perfume flavor, spice mix.
  7. 7.根据权利要求1所述水蛭提取物美容化妆品,其特征在于:所述的其它营养成分包括维生素类、珍珠水解液、氨基酸、多肽类物质、牛奶、胎盘素、蛋白、乳酸、各种微量元素;所述的特殊医药物质包括各种中草药、西药、如消炎抗菌药、防皱祛斑药。 7. The method of claim 1 leech extract cosmetics, characterized in that: the other nutrients include vitamins, pearl hydrolyzate, amino acid, peptide material, milk, placenta, protein, lactic acid, various trace elements; the specific substances include various herbal medicine, medicine, such as anti-inflammatory antimicrobial agents, anti-wrinkle cream medicine.
  8. 8.一种如权利要求1所述水蛭提取物美容化妆品的制备方法,其特征在于:膏状体美容护肤化妆品生产方法是:先按一定比例的油类、脂肪酸酯、有机溶剂和适量的精制水混合,加热至60-90℃,使其融合,冷却到50℃时边搅拌边加入其它营养成分或特殊医药物质,待其冷却到室温时再加入水蛭提取物和适量的香精,然后充分搅拌使之完全均匀得到产品。 8. A method of preparing the extract of a leech cosmetics claim, wherein: paste body skin care cosmetics production methods: press a certain percentage of oil, fatty acid esters, and the amount of the organic solvent purified water were mixed and heated to 60-90 deg.] C, which are fused, cooled with stirring to 50 deg.] C when added with other nutrients or special pharmaceutical substance, and then add an appropriate amount of leech extract flavor when let it cool to room temperature and then sufficiently stirring to obtain a completely uniform product.
  9. 9.一种如权利要求1所述水蛭提取物美容化妆品的生产方法,其特征在于:液体状美容护肤化妆品制备方法是把一定比例的油类、脂肪酸酯、有机溶剂和适量的精制水混合后,加热至60-90℃,使其融合,待其冷却到室温时再加入水蛭提取物和适量的香精,然后充分搅拌使之完全均匀得到产品。 A production process as claimed in claim 1 leech extract the cosmetics, which is characterized in that: a liquid cosmetic skin care preparation is to mix a proportion of oils, fatty acid esters, an organic solvent and an appropriate amount of purified water after heating to 60-90 deg.] C, which are fused, and then add an appropriate amount of leech extract flavor when let it cool to room temperature and then sufficiently stirred to obtain completely uniform product.
  10. 10.一种如权利要求1所述水蛭提取物美容化妆品的生产方法,其特征在于:啫哩状美容护肤化妆品生产方法是先把基质做成啫哩状,然后在室温下添加一定数量的水蛭提取物,然后充分搅拌使之完全均匀得到产品。 10. A method of producing a leech extract the cosmetics claim, wherein: jelly-like cosmetic skin care method for producing the matrix is ​​made of gel like first, and then add a certain amount of leeches at room temperature extract, followed by thorough stirring to obtain a completely uniform product.
CN 03140487 2003-09-12 2003-09-12 Leech extract cosmetics and method for making same CN1259034C (en)

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CN101966137A (en) * 2010-09-30 2011-02-09 天津市中科健新材料技术有限公司 Multi-efficacy skin-care preparation composition as well as preparation method and application thereof
CN102178635A (en) * 2011-04-27 2011-09-14 重庆时珍阁普生药业有限公司 Use of leech for cleaning skin, skin cleaning composition and preparation method thereof
CN102188359A (en) * 2011-04-27 2011-09-21 重庆时珍阁普生药业有限公司 Application of leech to nursing of hair or scalp of head, composition and preparation method
CN102188360A (en) * 2011-04-27 2011-09-21 重庆时珍阁普生药业有限公司 Application of leech to improvement of black eyes or eye puffiness, composition and preparation method of composition
CN102335101A (en) * 2011-02-18 2012-02-01 苏州润新生物科技有限公司 Cosmetic with freckle removal function
CN102753202A (en) * 2009-10-15 2012-10-24 国家科研中心 Use of extract of leeches as anti-bacterial agent
CN103006511A (en) * 2012-12-21 2013-04-03 山东侨牌集团有限公司 Hirudin skin-whitening moisture-keeping conditioning cream and production process thereof
CN103006512A (en) * 2012-12-21 2013-04-03 山东侨牌集团有限公司 Hirudin anti-winkle face-softening conditioning cream and production process thereof
CN103405375A (en) * 2013-08-09 2013-11-27 宋延坤 Hirudinaria manillensis active extract and preparation method and application thereof
CN103550126A (en) * 2013-11-08 2014-02-05 王洪博 Biological acne-removing and scar-lightening repairing emulsion
CN103690393A (en) * 2013-12-30 2014-04-02 王洪博 Skin-whitening anti-wrinkle biological silk mask
CN103705394A (en) * 2013-12-30 2014-04-09 王洪博 Biological silk mask capable of removing acne and eliminating mark
CN104784063A (en) * 2015-04-07 2015-07-22 巫远程 Compound for beauty and skincare product as well as manufacturing method of the compound
CN105078802A (en) * 2014-05-15 2015-11-25 钱如力 Acidic polypeptide transdermal caring agent and method for preparing same
CN105997559A (en) * 2016-05-11 2016-10-12 南京泽丽生物技术有限公司 Skin-beautifying and anti-pox composition and preparing method thereof
CN106344483A (en) * 2016-08-29 2017-01-25 重庆志微生物技术有限公司 Hirudo nipponia acne removal face cream, preparation method and application of hirudo nipponia acne removal face cream

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* Cited by examiner, † Cited by third party
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CN102753202B (en) * 2009-10-15 2016-03-30 国家科研中心 Leech extract thereof as an antibacterial agent
CN102753202A (en) * 2009-10-15 2012-10-24 国家科研中心 Use of extract of leeches as anti-bacterial agent
CN101966137B (en) 2010-09-30 2014-06-18 天津市中科健新材料技术有限公司 Multi-efficacy skin-care preparation composition as well as preparation method and application thereof
CN101966137A (en) * 2010-09-30 2011-02-09 天津市中科健新材料技术有限公司 Multi-efficacy skin-care preparation composition as well as preparation method and application thereof
CN102335101A (en) * 2011-02-18 2012-02-01 苏州润新生物科技有限公司 Cosmetic with freckle removal function
CN102178635B (en) 2011-04-27 2012-10-10 重庆时珍阁普生药业有限公司 Use of leech for cleaning skin, skin cleaning composition and preparation method thereof
CN102188360B (en) 2011-04-27 2012-06-06 重庆时珍阁普生药业有限公司 Application of leech to improvement of black eyes or eye puffiness, composition and preparation method of composition
CN102188359B (en) 2011-04-27 2012-05-30 重庆时珍阁普生药业有限公司 Application of leech to nursing of hair or scalp of head, composition and preparation method
CN102188360A (en) * 2011-04-27 2011-09-21 重庆时珍阁普生药业有限公司 Application of leech to improvement of black eyes or eye puffiness, composition and preparation method of composition
CN102188359A (en) * 2011-04-27 2011-09-21 重庆时珍阁普生药业有限公司 Application of leech to nursing of hair or scalp of head, composition and preparation method
CN102178635A (en) * 2011-04-27 2011-09-14 重庆时珍阁普生药业有限公司 Use of leech for cleaning skin, skin cleaning composition and preparation method thereof
CN103006512A (en) * 2012-12-21 2013-04-03 山东侨牌集团有限公司 Hirudin anti-winkle face-softening conditioning cream and production process thereof
CN103006511A (en) * 2012-12-21 2013-04-03 山东侨牌集团有限公司 Hirudin skin-whitening moisture-keeping conditioning cream and production process thereof
CN103006511B (en) * 2012-12-21 2015-04-22 山东侨牌集团有限公司 Hirudin skin-whitening moisture-keeping conditioning cream and production process thereof
CN103405375A (en) * 2013-08-09 2013-11-27 宋延坤 Hirudinaria manillensis active extract and preparation method and application thereof
CN103550126A (en) * 2013-11-08 2014-02-05 王洪博 Biological acne-removing and scar-lightening repairing emulsion
CN103705394A (en) * 2013-12-30 2014-04-09 王洪博 Biological silk mask capable of removing acne and eliminating mark
CN103705394B (en) * 2013-12-30 2016-03-23 广东丽姿生物科技有限公司 Biological elimination silk mask marks Acne
CN103690393A (en) * 2013-12-30 2014-04-02 王洪博 Skin-whitening anti-wrinkle biological silk mask
CN103690393B (en) * 2013-12-30 2016-07-13 广东丽姿生物科技有限公司 Silk mask whitening anti-wrinkle biological
CN105078802A (en) * 2014-05-15 2015-11-25 钱如力 Acidic polypeptide transdermal caring agent and method for preparing same
CN104784063A (en) * 2015-04-07 2015-07-22 巫远程 Compound for beauty and skincare product as well as manufacturing method of the compound
CN105997559A (en) * 2016-05-11 2016-10-12 南京泽丽生物技术有限公司 Skin-beautifying and anti-pox composition and preparing method thereof
CN106344483A (en) * 2016-08-29 2017-01-25 重庆志微生物技术有限公司 Hirudo nipponia acne removal face cream, preparation method and application of hirudo nipponia acne removal face cream

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