CN105662944A - Whitening cream for removing wrinkles and tendering skins as well as preparation method thereof - Google Patents
Whitening cream for removing wrinkles and tendering skins as well as preparation method thereof Download PDFInfo
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- CN105662944A CN105662944A CN201610029026.8A CN201610029026A CN105662944A CN 105662944 A CN105662944 A CN 105662944A CN 201610029026 A CN201610029026 A CN 201610029026A CN 105662944 A CN105662944 A CN 105662944A
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/36—Carboxylic acids; Salts or anhydrides thereof
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
- A61K8/345—Alcohols containing more than one hydroxy group
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- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
- A61K8/65—Collagen; Gelatin; Keratin; Derivatives or degradation products thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/67—Vitamins
- A61K8/676—Ascorbic acid, i.e. vitamin C
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/67—Vitamins
- A61K8/678—Tocopherol, i.e. vitamin E
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/02—Preparations for care of the skin for chemically bleaching or whitening the skin
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- A—HUMAN NECESSITIES
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- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
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Abstract
The invention provides a whitening cream for removing wrinkles and tendering skins. The cream comprises the following components in parts by weight: 20-40 parts of a Glycyrrhizae glabrae condensed stock solution, 30-50 parts of glycerin, 15-30 parts of edible raw pulp white vinegar, 5-10 parts of vitamin C, 5-25 parts of a rose extract product or a rose condensed stock solution, and 2-5 parts of hirudin. The whitening cream for removing wrinkles and tendering skins can be used for removing wrinkles, tendering skins and whitening skins.
Description
Technical field
The present invention relates to makeup technical field, be specifically related to a kind of wrinkle removal skin care skin whitener and preparation method thereof.
Background technology
The scientist (D.Hamam) of Britain in 1956 finds that free radical is the arch-criminal causing human senility first. This discovery produces to cause a sensation in the world, and the development of the mankind is created tremendous influence. The infringement of radical pair human body is the basic reason of human senility, and reflection is to body surface indirectly, and its phenomenon is exactly: one is xerosis cutis; Two is that skin of face is lax produces wrinkle then; Three is corse sweat pore; Four is facial colour spot; Five is senile plaque; Six is form acne, skin sore; Seven is skin allergy; Eight is that the intensely dark pool blackening of skin etc. brings huge infringement to the skin of human body.
Often tan by the sun under the sun, melanic cell in meeting human activin, and accelerate synthesis of melanin, here it is emphasize that summer to carry out the reason of sun-proof work why. Also have bad living habit, melanin also can be made to increase. Along with the increase at age, melanin catabolic enzyme ability reduces, it is easier to form mottle. Human body produces and the melanic ability of metabolism is among certain state balance, and this balance maintains the relatively stable of human body complexion, once melanin increases, then the colour of skin will blackening.
Melanin is high-molecular biologic pigment, Skin Cell " production " melanic initiation material is tyrosine, tyrosine is a seed amino acid very common in human body, in cell melanosome, tyrosine, by generating DOPA after tyrosinase catalysis, forms DOPA quinone after DOPA dehydrogenation, and it is rearranged into 5,6 oxyindoles, combine after indole polymerization formation melanoprotein, melanoprotein namely the melanin that we generally say with the structural protein in melanosome.
Enzyme (enzyme), also having person is ferment, various active protein substance synthesize, its specific substrate is played the protein of efficient catalytic effect, be also called biocatalyzer. In organism, various chemical reactions are nearly all carry out under the catalysis of enzyme. Enzymatic reaction has high catalytic efficiency, generally high 107-1020 times than uncatalyzed reaction. But, the catalysis activity of enzyme is also by many-sided regulation and control. Substrate is had the specificity of height by enzyme, and a kind of enzyme acts only on a compounds or certain chemical bond, to promote certain chemical change, and generates certain product, and this phenomenon is also referred to as the specificity of enzyme or specificity (specificity). Skin color is mainly determined by melanic content in skin, and in melanocyte, melanic biosynthesis is by enzymatic a succession of oxidation reaction. Tryrosinase is the Major Enzymes of synthesis of melanin, plays a crucial role in multiple reactions steps of building-up process.
The mechanism of catalytic reaction of tryrosinase is always concerned, it is believed that the member point of tryrosinase only one of which double-core, also it is believed that at least there are two different active sites in tryrosinase.No matter its mechanism of action is how, and tryrosinase is melanogenic key enzyme, rate-limiting enzyme, this point be do not have doubt. The activity of tryrosinase not only determines the speed of melanin genesis, or the characteristic mark that melanocyte differen-tiation is ripe, experiment also demonstrates tyrosinase activity and melanin genesis amount is proportionate and is, its activity change can cause dyschromicum dermatosis such as chloasma, this is also that everybody spends great effort research tyrosinase activity to activate and the reason suppressed, if tyrosinase activity can be suppressed successfully, safely, then whitening and speckle dispelling just can realize.
The catalytic tyrosine of tryrosinase generates in melanic course of reaction must have copper ion to participate in, and this is a very important feature, and meanwhile, reaction also needs to oxygen-derived free radicals and participates in. From this sense, tryrosinase is a kind of cupric aerobic enzyme. The accurate of skin regulatory mechanism has some idea of at this, melanic generation process, is also the self-reset procedure of oxygen-derived free radicals in fact. The reactions steps that its melanin is formed is:
1. by the tryrosinase of cupric, depositing in case at oxygen-derived free radicals, catalytic oxidation tyrosine generates DOPA, and this single step reaction proceeds by very slow, but reaction is accelerated after DOPA is formed;
2. DOPA is changed into DOPA quinone under tyrosinase catalysis, and DOPA quinone has two kinds of Consumptions, and the first continues to be changed into melanocyte, and the second is changed into pheomelanin after interacting with cysteine, and pheomelanin is more of light color than melanocyte. In melanic biosynthetic process, it is possible to by suppressing the carrying out of tyrosinase activity or each blocking reaction in reaction chain to reduce melanic synthesis, this is one of the Basic Mechanism of current whitening and speckle dispelling formula for a product design. Melanin is uniform excess deposition in skin epidermis, the colour of skin will blackening, melanin local excess deposition, be formed freckle, the cardinal principle of chloasma. Tryrosinase plays a crucial role in multiple reactions steps of melanin synthesis process, is the key enzyme of melanin generation, rate-limiting enzyme.
Tryrosinase is converted into DOPA tyrosine, DOPA is the raw material of synthesis of melanin in human body, is also synthesize adrenergic raw material, and epinephrine is a kind of very important hormone in human body, so tryrosinase can not be destroyed, but can try every possible means to suppress its activity. The suppression of enzymatic activity belongs to biochemical category, on biochemistry, every can reduce enzymatic reaction speed, but do not cause the material that enzyme molecule degeneration inactivates to be referred to as enzyme inhibitor, the effective object of enzyme, namely " raw material ", Biochemical Nomenclature is called substrate. Tyrosinase catalysis tyrosine generates in melanic enzymatic reaction, and tyrosine is exactly substrate. Inhibitory action is divided into irreversible suppression and the big class of reversible inhibition two.
The Irreversible inhibition of enzyme refers to the essential group covalent bond of inhibitor and enzyme molecule, thus inhibitory enzyme activity, and enzymatic activity can not adopt the straightforward procedures such as dialysis to recover. Irreversible suppression includes specificity and suppresses and non-specific suppression. Being combined, with enzyme molecule reversibility, the inhibitor causing enzymatic activity to reduce with non-covalent bond, claim reversible inhibitor, reversible inhibition is divided into the several types such as competitiveness, Noncompetition inhibition.
1. competitive inhibition: inhibitor is combined with the same active center of enzyme with substrate competition, thus disturbing the combination of enzyme-to-substrate, makes the catalysis activity of enzyme reduce, and competitive inhibitor is often substrate analogue or the product of enzyme;Inhibitor is identical with the binding site of enzyme with substrate with the binding site of enzyme; Inhibitor concentration is more big, then inhibitory action is more big;
2. Noncompetition inhibition: noncompetitive inhibitor both can be combined with enzyme, can also be combined with enzyme, substrate complex, the catalysis activity making enzyme reduces, substrate and inhibitor separately combine with the different parts of enzyme, noncompetitive inhibitor is on the combination of enzyme-to-substrate without impact, therefore the change of concentration of substrate is on suppressing degree without impact.
At present, at whitening and speckle dispelling formula for a product design aspect, tyrosinase activity suppresses commonplace mechanism to be competitive type.
The essence that competitive suppresses is: adding a kind of chemicals, its structure and substrate are much like, and allowing enzyme " takeing for " is substrate, and it combines, and it is carried out catalysis, and result is to catch at shadows. Tryrosinase starts catalysis using tyrosine as substrate, add a kind of structure and tyrosine material relatively, tyrosine and additive are combined by tryrosinase simultaneously, catalysis, result is that tyrosine is converted into melanin, additive is effect no, its net result is that practical function is few in the enzyme quantity of tyrosine, and the melanin amount of production is naturally just few. This mechanism be easier understand, chemically in structure can also initial guess, screening whitening additive, Application comparison is easy. Hydroquinone is an example of competitive inhibiting mechanism application, the precursor structure of tyrosine is a phenyl ring and a hydroxyl, hydroquinone chemical constitution is hydroquinone (phenyl ring and two hydroxyls), structure is close, hydroquinone and tyrosine are combined with tryrosinase simultaneously, producing competition, result hydroquinone consumes a part of tryrosinase. At present with relatively more whitening additive arbutin are also belonging to competitive inhibiting mechanism.
Natural plant kind cosmetics are the development trends of current China cosmetics research and development, plant extract fine Huawei the Chinese herbal medicine represented is then functional cosmetics one fashion. Natural Chinese medicinal herb class cosmetics, raw material is extensive, composition is natural, product safety, be beneficial to environmental protection and meet the theory of sustainable development, is also one of product advantage attracting consumer. Thus it is necessary to develop a kind of wrinkle removal skin care skin whitener, cater to new period people to beautiful pursuit.
Summary of the invention
An object of the present invention is in that to overcome the above-mentioned deficiency of prior art to provide a kind of wrinkle removal skin care skin whitener, and this wrinkle removal skin care skin whitener can wrinkle removal, skin care, whitening.
The two of the purpose of the present invention are in that the preparation method providing above-mentioned wrinkle removal skin care skin whitener.
Wrinkle removal skin care skin whitener of the present invention, in parts by weight, including following composition:
Glycyrrhiza glabra L. concentration stock solution 20-40 part, glycerol 30-50 part, edible food raw juice white vinegar 15-30 part,
Vitamin C 5-10 part, rose extract or Flos Rosae Rugosae concentration stock solution 5-25 part, hirudin 2-5 part.
The preferred 5-7 part of wherein said rose extract.
Wherein said hirudin is natural hirudin lyophilized powder.
Wrinkle removal skin care skin whitener of the present invention can also add rose essence 1-1.5 part.
Wrinkle removal skin care skin whitener of the present invention can also add vitamin E2-4 parts.
Wrinkle removal skin care skin whitener of the present invention can also add collagen protein polypeptide 3-10 part.
The concentration of wherein said Glycyrrhiza glabra L. concentration stock solution is 30-40%, and preparation method is as follows:
The first step: pulverized by Glycyrrhiza glabra L. raw material, puts in reaction vessel, soaks 4-6 hour, and the weight ratio of Glycyrrhiza glabra L. and water is 2:(10-15);
Second step: after Glycyrrhiza glabra L. is soaked 4-6 hour, heats to 70-80 degree, reacts 40-60 minute, cool down 25-40 minute, is again warming up to 70-80 degree slowly and reacts 40-60 minute, centrifugation;
3rd step: taking centrate, to be concentrated into weight concentration be 30-40%, with decolorizing with activated carbon, adds 600-800 order filter cloth with sheet frame and filters, obtain Glycyrrhiza glabra L. concentration stock solution.
Wherein said Flos Rosae Rugosae concentration stock solution concentration is 30-40%, and preparation method is as follows:
The first step: pulverized by Flos Rosae Rugosae, puts in reaction vessel, soaks 4-6 hour, and the weight ratio of Flos Rosae Rugosae and water is 2:(10-15);
Second step: after Flos Rosae Rugosae is soaked 4-6 hour, heats to 70-80 degree, reacts 40-60 minute, cool down 25-40 minute, is again warming up to 70-80 degree slowly and reacts 40-60 minute, centrifugation;
3rd step: taking centrate, to be concentrated into weight concentration be 30-40%, with decolorizing with activated carbon, adds 600-800 order filter cloth with sheet frame and filters, obtain Flos Rosae Rugosae concentration stock solution.
The preparation method of wrinkle removal skin care skin whitener of the present invention, in turn includes the following steps:
The first step: Glycyrrhiza glabra L. stock solution is placed in container, batch production other Ingredients Weight except glycerol and edible food raw juice white vinegar is calculated by formula proportion, first rose extract or Flos Rosae Rugosae concentration stock solution are slowly added in Glycyrrhiza glabra L. stock solution, after stirring 5-10 minute, again natural hirudin lyophilized powder is added, stir 5-10 minute, then after adding vitamin C and other composition, stir 15-20 minute, obtain wrinkle removal skin care skin whitener intermediate.
Second step: glycerol is calculated batch quantity produced by formula proportion and is placed in container, the quantity that edible food raw juice white vinegar batch produces is calculated again by formula proportion, then edible food raw juice white vinegar is slowly added in glycerol container, stirs 10-15 minute, obtain glycerol vinegar mixed liquor.
3rd step: glycerol vinegar mixed liquor is placed in container, then the wrinkle removal skin care skin whitener intermediate first step obtained joins in glycerol vinegar mixed solution container, mix and blend 10-15 minute, obtains wrinkle removal skin care skin whitener.
4th step: by wrinkle removal skin care skin whitener terminal sterilization in bulk, then Packaging Bottle high temperature sterilize, wrinkle removal skin care skin whitener detects, every bottle of 100ml fill, warehouse-in.
Wrinkle removal skin care skin whitener sphere of action of the present invention: the intensely dark pool of skin, whitening, realize fair and clear skin, disappear canthus wrinkle of dispelling, crows-feet, forehead stricture of vagina, disappear functions of removing chloasma, butterfly spot, day sunburn, cyasma (cholasma uterinum), chorioplaque, black speck, passeris montani saturati speckle, sunburn, senile plaque, hydrargyrum speckle, tinea versicolor, sanguinin speckle, endocrine disturbance's speckle, water deficient speckle, cosmetic chemistry injury speckle, the melanin of all kinds of mottles such as Environmental Chemistry smudging and difficult miscellaneous diseases speckle, eliminate and desalinate all kinds of mottles, improve skin texture at all, quick de-black whitening, quickly eliminating stain, defying age, skin care skin care, moisturizing.
The using method of wrinkle removal skin care skin whitener of the present invention is as follows: air-dry after 1, being cleaned by skin with warm water; 2, crossing to drip by bottle and 3 to 5 drop in the palm of the hand, be put on and loop on the face, then the palm of the hand pats face more gently to fully absorbing after repeatedly soft, face brightens and tenderizes; 3, adhere to every day sooner or later respectively once.
Wrinkle removal skin care skin whitener action principle is as follows:
In wrinkle removal skin care skin whitener, bioactive small molecule is only one of traditional plant seventy points extracting essential ingredient, it is easier to through human skin basal layer, absorb by half an hour after, its major function effect, it is by improving the microcirculation of skin and nutriture, blood circulation promoting and blood stasis dispelling, balance pigment, fundamentally solve skin moisture-keeping, the various fleckiness of wrinkle-chasing, flat wrinkle skin care skin care whitening problem, make skin smooth fine and smooth, within 30 days, reach ideal effect.
The action principle first step: rapid osmotic skin, removes blood capillary metabolism and residual waste rubbish
Wrinkle removal skin care skin whitener Main Ingredients and Appearance hirudin, rose active composition rapid osmotic skin, act on skin texture layer, go deep into bottom pore, improve capillary of skin permeability, remove dirt toxin in the skin such as blood capillary metabolism and residual waste rubbish, carbon dioxide, the blood capillary making alluvial is improved dredging, and face microcirculation recovers normal, and black eye desalinate disappearance gradually.
Composition hirudin in wrinkle removal skin care skin whitener, the single chain polypeptide being made up of 65-66 aminoacid, molecular weight is 7000 dalton, other nutrient substance can be helped to penetrate to the skin rapidly deep layer, easily absorbed by Skin Cell, hirudin can reduce blood viscosity, accelerate blood flowing speed, dredging blood capillary, improve blood vessel microcirculation, promote skin metabolism, cell is made to obtain the nutrient of abundance, delay skin aging, promote the self-regeneration of chrotoplast, make skin fine and smooth, shrink thick pore, especially to acne, acne, red and swollen, facial pigmentation deposits, Skin indentation is repaired, whitening, promote that cell regeneration has unique beauty and skin care effect.
Action principle second step: quickly eliminate scytitis, wake cell viability up
Quickly eliminate scytitis, be first turned off melanin and generate root, reduce tyrosinase activity, wake cell viability up, optimize the living environment of cell, strengthen eye part skin resistance to external world and tolerance level, making eye skin moisturizing, deep layer is white eye skin only.
With advancing age, in human body, lipid peroxide (rust also known as human body) can be continuously increased, and causes the function of cell normally to play. When cylinder super-oxidation lipid is too much, can combine with internal material, generate and have virose peroxidic species. If this phenomenon occurs on skin, the metabolic capabilities that can make skin goes down, and easily make refuse accumulate in skin surface, form senile plaque, also can make the tension reduction of skin or elastic reduce, increase the wrinkle of skin and become lax, and if secrete the sebaceous gland of oils and fats and the sweat gland function decline of perspiration, skin will lose moist composition, in advance aging.
Composition edible food raw juice vinegar in wrinkle removal skin care skin whitener, hirudin, its force action has very strong sterilization, bacteriostasis. Bacillus bacterium, Micrococcus bacterium, pseudomonas fluorescens and prosperous Pian Shi coccus, staphylococcus aureus, Salmonella typhimurtum and pathogenicity coliform etc. can be killed suppression breeding completely. As long as acetate concentration is more than 122 mg/litre, if half a minute just can kill completely staphylococcus, Salmonella enteritidis, shigella sonnei, secondary dissolved oxygen vibrio, to cause of disease coliform, also only need half a minute just can all kill.
Research also shows, edible food raw juice vinegar to first kind streptococcus, blocked the respiratory tract microorganisms such as coccus, Diplococcus pneumoniae, Staphylococcus albus and influenza virus and had deactivation, latter 30 minutes, except having individual colonies except first streptococcus, it has been found that all the other are killed entirely are smoked in indoor. Test is it is also shown that vinegar has the effect killing diphtheria corynebacterium and epidemic cerebrospinal meningitis, measles, cheek line inflammation virus. For the various bacteria such as bacillus pyocyaneus, Trichophyton, fungus, vinegar also can have very strong kills ability. The compounds such as acetic acid in edible food raw juice vinegar, lactic acid, aminoacid, glycerol and aldehydes, have soft stimulation to the skin of people, can distend the blood vessels, and increase cutaneous circulation, make skin smooth.On tcm clinical practice and in folk remedy, all vinegar is widely used for the multiple disease of preventing and treating surgery, department of dermatologry, and achieves good effect.
Action principle the 3rd step: efficiently lock water, moisturizing, antioxidation
Glycerol, vitamin C is " spring in youth " by scientist's good reputation, as one of most important Natural antioxidant, and draw the moisture content in air to skin moisture-keeping, also the moisture content in skin can be pinned, natural protective barrier from interior reinforcing skin, it is a kind of critically important vasodilation and anticoagulant, Main Function antioxidation, protection body cell is from the murder by poisoning of free radical, protect the skin from the injury of ultraviolet and pollution, reduce the deposition of cicatrix and pigment, improve lipid metabolism, prevention coronary heart disease, atherosclerosis, prevention and treatment varicosis, prevention of inflammation dermatoses, baldness, prevention hemolytic anemia, protection erythrocyte is so as to be not easy to break, prophylactic treatment thyroid disease, improve blood circulation, the solidification of anti-Hemostatic Oral Liquid, reduce the generation of speckle tissue, spot-removing beautifying face, moisture-locking, moisturizing, triple beautiful effect that skin-active is wrinkle resistant.
Action principle the 4th step: whitening, skin care
Whitening, skin care are the themes of wrinkle removal skin care skin whitener action and efficacy, being one of composition in wrinkle removal skin care skin whitener, Glycyrrhiza glabra L. is referred to as " whitening gold ", and it can promote cell metabolism, strengthen skin opposing uv damage, allow skin recover fair and clear transparent skin quality. Glycyrrhiza glabra L. stock solution has superpower suppression tryrosinase oxidation activity and the function preventing liposome oxidized. Tryrosinase is composition necessary to cell synthesis of melanin, Glycyrrhiza glabra L. stock solution can act on the melanocyte of stratum basale near the eyes, suppress the activity of arch-criminal's tryrosinase of melanin deposition, obstruction melanin is formed, simultaneously anti-lipid peroxidation, promotes the division rapidly of regenerative cell, propagation, unnecessary melanic metabolism in acceleration bodies, eliminate melanin deposition and mottle that skin around the eyes produces, reach to eat up melanin, reduce the effect of the colour of skin near the eyes.
Wrinkle removal skin care skin whitener have employed and automatically removes melanic association principle, thus allowing the active ingredient Glycyrrhiza glabra L. in wrinkle removal skin care skin whitener fixed (Glabridin) and Glycyrrhiza glabra L. element (Glabrene), aminoacid pins activity, thus avoiding melanic generation, contain that source occurs melanin. Melanin effect is sneered, thus repairing skin melanin accumulation damaged tissues again reach the effect of skin care whitening it addition, wrinkle removal skin care skin whitener also has actively to gulp down.
Melanin is transformed by tyrosine (amino acid whose one), but tyrosine becomes one condition of melanin demand: be exactly the participation of tryrosinase, if this enzyme can not be synthesized, melanin cannot generate, composition in wrinkle removal skin care skin whitener has antioxidation and reduction effect, the activity of tryrosinase can be pinned, so as to lose usefulness. It addition, the active ingredient of wrinkle removal skin care skin whitener can accelerate the absorption of free radical, heat clearing away is soothing the liver, assists a ruler in governing a country distension related to the liver removing toxic substances waste discharge, promotes repair of damaged tissues, strengthen hepatic and renal function. Wrinkle removal skin care skin whitener is generally used after 2 days, just to see wrinkle removal skin care whitening effect.
Wrinkle removal skin care skin whitener time effect is as follows:
With advancing age, in the sear and yellow, lose one's charm with years, there is wrinkle in skin, fleckiness, obscure, this is the process being difficult to avoid that, but wrinkle removal skin care skin whitener can allow you realize the hope of whitening and softening skin, allows you reappear youth, skin beautiful, pale, elastic.
Using the front obscure jaundice of skin color, scaly dry skin hydropenia, have pigementation and wrinkle, pox print, fleckiness, xerosis cutis has microgroove, and water content is low, and water loss speed is fast.
Use wrinkle removal skin care skin whitener effect after 2 days: substantially experiencing wrinkle removal skin care skin whitener to the reparation of skin and nourishing, skin moisture increases, no longer greasy, and skin sore reduces; Skin lightening degree on average improves 2-3 degree, slightly whiter than before using, and substantially feels soft and smooth during touch.
Use wrinkle removal skin care skin whitener effect after 7 days: black speck, pox print, wrinkle are substantially thin out, skin lock outlet capacity is strengthened, and skin lightening degree on average improves 3-5 degree, fine and smooth soft, and skin ratio significantly bleaches before using and attenuates. Whitening factor rapid osmotic, to deep skin, is cut off melanin and is generated root, crack melanin, use one week after date skin substantially fine and smooth, glossy, and skin highlights two colourities.
Use wrinkle removal skin care skin whitener effect after 15 days: skin is fine and smooth, compact, wrinkle, eye pouch, black speck, pox print, skin sore disappear substantially, ability and the self-recovery ability of skin opposing environmental stimuli are significantly strengthened, and skin lightening degree on average improves 5-6 degree. Ruddy, tender white, coloured and dazzling, whole skin presents the tender white state of young healthy.
Use wrinkle removal skin care skin whitener effect after 30 days: hirudin, rose active composition act on skin texture layer, go deep into bottom pore, remove in skin residue and top layer pigment rubbish in dirt, pore, the effect of early stage will comprehensively be solidified and be promoted, whitening skin children is tender, gentle and demure moving, high resilience and gloss, melanocyte metabolism restores balance.
The primary raw material medicine that the present invention uses illustrates as follows:
(1) edible food raw juice white vinegar:
[National Standard of the People's Republic of China] making vinegar (GB18187-2000)
Research it is also shown that edible food raw juice vinegar to first kind streptococcus, blocked the respiratory tract microorganisms such as coccus, Diplococcus pneumoniae, Staphylococcus albus and influenza virus there is killing action.
Test also shows that diphtheria corynebacterium and epidemic cerebrospinal meningitis, measles, cheek line inflammation virus are had the effect killed. For the various bacteria such as bacillus pyocyaneus, Trichophyton, fungus, vinegar also can have very strong kills ability.
The compounds such as acetic acid in edible food raw juice vinegar, lactic acid, aminoacid, glycerol and aldehydes, have soft stimulation to the skin of people, can distend the blood vessels, and increase cutaneous circulation, make the effect of skin smoothness, skin care, skin protection.
(2) Glycyrrhiza glabra L.:
Glycyrrhiza glabra L., has another name called, G1ycyrrhiza glabra, G1ycyrrhiza glabra perennial herb, and root is sturdy with root stock, diameter 0.5-3cm, root bark brown, and the inside yellow has sweet taste. Stem is upright, multi-branched, high 0.5-1.5m, and base portion band is wooden, and close by faint yellow flakey gland point with white pubescence, during children, tool bar rib, has short setiform body of gland sometimes. Seed dirty-green, smooth, kidney shape, diameter about 2 millimeters. The month at florescence 5-6, fruit month phase 7-9.
There is the skin depigmentation that antioxygenic activity is very strong in the root of Glycyrrhiza glabra L., root stock histiocyte, the functional component of desalination mottle, is again main component, i.e. Glycyrrhiza glabra L. element (Glabrene) and Glycyrrhiza glabra L. fixed (Glabridin). Glycyrrhiza glabra L. is fixed, molecular formula C20H2004, molecule relative mass 324.28, for colourless powder body, water insoluble, and at methanol, ethanol and dissolving in ether equal solvent. Glycyrrhiza glabra L. is fixed and many components of cosmetics are fully inclusive and equitable, and compatibility is good, will not produce Antagonism reaction.
(3) glycerol:
Content is revised and enlarged in the revision of [Chinese Pharmacopoeia] 2010 editions Chinese Pharmacopoeias, and glycerol is without the sweet clear and bright thick liquid of color and taste, odorless, has warm sweet taste, is commonly called as glycerol, can absorb moisture, also can absorb hydrogen sulfide, Blausure (German) and sulfur dioxide from air.It is insoluble in benzene, chloroform, carbon tetrachloride, Carbon bisulfide, petroleum ether and oils.
(4) vitamin C:
It is in close relations with health that vitamin C (has another name called ascorbic acid), it it is a kind of important and special water soluble vitamins, there is molecular structure the simplest, physicochemical property is least stable, human body daily requirement amount is maximum, meals are distributed the special nature such as concentration the most, have multiple important effect maintaining human normal function aspects.
Vitamin is that a class maintains the general name of low-molecular-weight organic compound necessary to body normal physiological function. The vitamin generally acknowledged at present mainly has 13 kinds, is called " The Heroic Ones " of vitamin family visually. In vitamin family, vitamin C is comparatively special, has many species specificity and a series of physiological function, human health status and food value are had large effect. Owing to vitamin C has antiscorbutic effect, and there is organic acid character and obvious tart flavour, therefore have another name called ascorbic acid (ascorbicacid).
(5) Flos Rosae Rugosae:
2010 editions Chinese Pharmacopoeias, another name; Hover flower, nib flower, lake flower, Flos Rosae Davuricae, thorn rose chrysanthemum. Belong to Rosales, Rosaceae machaka, the many acupuncture of branch bar, imparipinnate leaf, 5～9, lobule, ellipse, have limit to sting. Petal obovate, polyphyll is to half polyphyll, and flower has aubergine, white, fruit month phase 8-9, oblate spheroid. When Flos Rosae Rugosae is as crops, its flower is mainly used in food and refines essence Oleum Rosae Rugosae, and Oleum Rosae Rugosae is applied to the industry such as cosmetics, food, fine chemistry industry. Efficacy effect: promoting QI circulation for relieving depression, and blood, pain relieving, for stomachache due to hyperactive liver-QI attacking the stomach, lack of appetite vomiting and nausea, menoxenia, fall and flutter the pain of injury.
(6) hirudin:
2010 editions Chinese Pharmacopoeias, hirudin (hirudin) is to have extracted a kind of composition that activity in various active composition is the most notable and studies at most, the small protein (polypeptide) that it is made up of 65 66 aminoacid in Hirudo (Leech) and salivary gland thereof. Thrombin is had extremely strong inhibitory action by hirudin, is found the natural specific inhibitor of the strongest thrombin up to now.
(7) vitamin E:
Vitamin E (VitaminE) is a kind of fatsoluble vitamin, and its hydrolyzate is tocopherol, is one of topmost antioxidant. [1] it is dissolved in the organic solvents such as fat and ethanol, water insoluble, heat, acid are stablized, alkali is unstable, oxygen is sensitive, heat is insensitive, but time fried, Vitamin E activity substantially reduces. Tocopherol can promote sex hormones secretion, makes man's motility of sperm and quantity increase; Make woman's estrogen concentration increase, improve fertility, prevention of miscarriage, it may also be used for prevent and treat the aspects such as male infertility, burn, cold injury, capillary hemorrhage, climacteric syndrome, beauty treatment.
(8) collagen protein polypeptide:
This word of polypeptide Peptide is from Greek π ε π τ óIt is derived, be meant to " digested ". By to collagen protein chain enzymatic hydrolysis, then extracting, become the hydrolytic collagen of resolvability, save the three helical polypeptide structures with three-dimensional activity.
Detailed description of the invention
Below in conjunction with embodiment, embodiment of the present invention are described in detail, it will be appreciated by those skilled in the art that the following example is merely to illustrate the present invention, and should not be taken as limiting the scope of the invention.
Table 1 is the Example formulations of wrinkle removal skin care skin whitener of the present invention. Wherein the concentration of Glycyrrhiza glabra L. concentration stock solution and Flos Rosae Rugosae concentration stock solution is 30%, and hirudin is natural hirudin lyophilized powder.
Table 1
Used by above example, the preparation method of Glycyrrhiza glabra L. concentration stock solution is as follows:
The first step: pulverized by Glycyrrhiza glabra L. raw material, puts in reaction vessel, soaks 4 hours, and the weight ratio of Glycyrrhiza glabra L. and water is 2:15;
Second step: after being soaked 4 hours by Glycyrrhiza glabra L., heat to 80 degree, react 40 minutes, cool down 30 minutes, is again warming up to 80 degree slowly and reacts 40 minutes, centrifugation;
3rd step: taking centrate, to be concentrated into weight concentration be 30%, with decolorizing with activated carbon, adds 600 order filter cloths with sheet frame and filters, obtain Glycyrrhiza glabra L. concentration stock solution.
Used by above example, the preparation method of Flos Rosae Rugosae concentration stock solution is as follows:
The first step: pulverized by Flos Rosae Rugosae, puts in reaction vessel, soaks 4 hours, and the weight ratio of Flos Rosae Rugosae and water is 2:15;
Second step: after being soaked 4 hours by Flos Rosae Rugosae, heat to 80 degree, react 40 minutes, cool down 30 minutes, is again warming up to 80 degree slowly and reacts 40 minutes, centrifugation;
3rd step: taking centrate, to be concentrated into weight concentration be 30%, with decolorizing with activated carbon, adds 600 order filter cloths with sheet frame and filters, obtain Flos Rosae Rugosae concentration stock solution.
The preparation method of above example wrinkle removal skin care skin whitener is as follows:
The first step: Glycyrrhiza glabra L. stock solution is placed in container, batch production other Ingredients Weight except glycerol and edible food raw juice white vinegar is calculated by formula proportion, first rose extract or Flos Rosae Rugosae concentration stock solution are slowly added in Glycyrrhiza glabra L. stock solution, after stirring 5-10 minute, again natural hirudin lyophilized powder is added, stir 5-10 minute, then after adding vitamin C and other composition, stir 15 minutes, obtain wrinkle removal skin care skin whitener intermediate.
Second step: glycerol is calculated batch quantity produced by formula proportion and is placed in container, the quantity that edible food raw juice white vinegar batch produces is calculated again by formula proportion, then edible food raw juice white vinegar is slowly added in glycerol container, stirs 10 minutes, obtain glycerol vinegar mixed liquor.
3rd step: glycerol vinegar mixed liquor is placed in container, then the wrinkle removal skin care skin whitener intermediate first step obtained joins in glycerol vinegar mixed solution container, mix and blend 10 minutes, obtains wrinkle removal skin care skin whitener stock solution.
4th step: by wrinkle removal skin care skin whitener stock solution terminal sterilization in bulk, then Packaging Bottle high temperature sterilize, wrinkle removal skin care skin whitener detects, every bottle of 100ml fill, warehouse-in.
Effect test:
(1) mensuration of free radical scavenging effect:
The concentration becoming concentration to be mass volume ratio 1% sample preparation of previous embodiment respectively with dimethyl sulfoxide, carries out following experiment.
Take sample solution 2ml and diphenyl picryl phenylhydrazine DPPH solution (solvent of this solution is for water) 2ml that concentration is 100umol/L and be initially charged in same tool plug test tube, shake up, left at room temperature 30 minutes, with solvent for blank, measures sample absorbance under 517nm wavelength.
Suppression ratio: k%=[1-(Ai-Aj)/AC] × 100%
The absorbance of Ai:2mlDPPH solution+2ml sample solution
The absorbance of Aj:2ml sample solution+2ml solvent (i.e. dimethyl sulfoxide)
The absorbance of AC:2mlDPPH solution+2ml solvent (i.e. dimethyl sulfoxide)
Experimental result is in Table 2:
Table 2
| Suppression ratio, % | |
| Embodiment 1 | 86.5 |
| Embodiment 2 | 85.5 |
| Embodiment 3 | 85.9 |
| Embodiment 4 | 86.8 |
| Embodiment 5 | 87.0 |
| Embodiment 6 | 89.9 |
| Embodiment 7 | 88.7 |
| Embodiment 8 | 89.9 |
| Embodiment 9 | 91.2 |
| Embodiment 10 | 90.9 |
| Embodiment 11 | 90.7 |
| Embodiment 12 | 91.5 |
Test result indicate that, the wrinkle removal skin care skin whitener of the present invention can effectively suppress the generation of free radical, and effect is notable.
(2) B16 cell test in mouse melanin cell is suppressed:
By B16 mouse melanin tumor cell with 1 × 105The density of individual/ml is connected to the culture dish that diameter is 9cm, at 37 DEG C of 5%CO2When, cultivates 2 days, abandons supernatant, adds the sample solution 18-22ml after filtration sterilization, being then incubated for 3 days, abandon supernatant, PBS washs, every hole adds the trypsin solution peptic cell 3min of 0.5ml mass percent 0.2%, and every ware adds 2ml maintenance medium and terminates digestion.After piping and druming mixing, every kind of concentration is taken out 0.5ml and is made cell counting, and all the other cell suspension are with the centrifugal 5min of 2500r/min, abandon supernatant, adding NaoH solution in precipitation, heating makes melanin dissolve, and selects to survey on the enzyme-linked immunosorbent assay instrument of 490nm wavelength absorbance.
B16 cell suppression ratio=(1-(medicine hole absorbance+medicine porocyte density)+(control wells absorbance+control wells cell density)) × 100%
Suppressing B16 cell test in mouse melanin cell, result is as shown in table 3:
Table 3
Clinical trial one:
(1) patient:
Selecting screening 240 examples to have the healthy population of freckle and speckle on the face, men and women does not limit, and is randomly divided into 12 groups, often organizes 10 people, uses the wrinkle removal skin care skin whitener of embodiment 1-12 respectively.
(2) using method:
1, skin is cleaned rear air-dry with warm water; 2, cross to drip by bottle and 3 to 5 drop in the palm of the hand, be put on after repeatedly soft and loop on the face, then the palm of the hand pats face more gently to fully absorbing; 3, adhere to every day sooner or later respectively once. Experimental period is 30 days.
Use color difference meter to often organize each experimenter measure use before and after the brightness of skin (represent by aberration meansigma methods, aberration meansigma methods is more big, show that skin is more bright), and by following standard, observe the effect to face's freckle and speckle of the whitening freckle cream.
Evaluation criterion: effectively: speckle, freckle substantially go down; Effective: speckle and freckle slightly go down; Invalid: unchanged. Concrete outcome is in Table 4.
Table 4
As seen from the above table, the whitening and speckle dispelling effect of experimental group is all fine.
Clinical trial two:
Clinical dossier five example:
A, 48 years old (Chenzhou, Hunan Province) age of Gong
Speckle type: born freckle
The use time: 2 months
Effect is commented on: beginning to use the embodiment of the present invention 6 wrinkle removal skin care skin whitener product in April, 2015, only employ 2 months, skin just there occurs change on the face, originally I had skin dark stain, yellowish-brown class on the face, and ratio is more serious, after this product, skin dark stain, chloasma has just been desalinated many, also this is originally glossy for skin, flexible, because the relation of working environment, the length worked in the wild, June one JIUYUE, skin tanning, repair through the two moon, return to again original gloss.
B, Zhang's (Luohe, Henan) 23 years old age
Speckle type: born freckle
The use time: 8 months
Effect is commented on: begin to use the embodiment of the present invention 8 wrinkle removal skin care skin whitener product in March, 2015, it is interrupted use, using nearly 8 months, product effect is, originally has skin dark stain, mottle on the face, the intensely dark pool of skin, nonelastic, before speckle on the face be substantially all without, and feel that skin is finer and smoother, also bleach, do not think dry, hydropenia.
C, so-and-so of king at (Guangdong-Zhanjiang) age 29
Speckle type: pigmentation spots
Use wrinkle 2 months skin whitener time of skin care
Effect is commented on: born face is just yellow, and after having gone to seabeach when more than 20 year old, speckle just comes. In several years, tried a lot of skin care item, DIY, laser, fruit acid what, all poor effect, some quickly takes effect, but one gets sun once in a while, and speckle is long again, and looks more. After begin to use the embodiment of the present invention 10 wrinkle removal skin care skin whitener product, initial several days, the edge of speckle started fuzzy diminishing, and used wrinkle skin care skin whitener 2 months, and speckle does not all have.
D, Mrs Lin (Sichuan-Chengdu) 36 years old age
Speckle type: born freckle
The use time: 4 months
Effect is commented on: before using the embodiment of the present invention 11 wrinkle removal skin care skin whitener product, goes to try the light speckle of laser, has tried later speckle really light, but soon just bounce-back is returned.Using the wrinkle general two weeks of skin care skin whitener just effect again, those point points are basic just so light that to cannot see, and bulk mottle is also unintelligible gradually, skin also becomes pale glossy. Within 4 months, people youthens in the past.
E, so-and-so of Lee at (Strain Hunan state) 33 years old age
Speckle type: born skin dark stain
The use time: 2 months
Effect is commented on: beginning to use the embodiment of the present invention 12 wrinkle removal skin care skin whitener product in April, 2014, after using 15 days, skin just there occurs change on the face, originally there is skin dark stain on the face, particularly back a bulk of speckle pox ratio is more serious, after having used this product, and skin dark stain, back a bulk of speckle pox has been desalinated many, after 2 months, speckle pox disappears, and skin is also more glossy than originally, flexible, repaired through 2 months, return to again original gloss.
Claims (9)
1. a wrinkle removal skin care skin whitener, it is characterised in that in parts by weight, including following composition: Glycyrrhiza glabra L. concentration stock solution 20-40 part, glycerol 30-50 part, edible food raw juice white vinegar 15-30 part, vitamin C 5-10 part, rose extract or Flos Rosae Rugosae concentration stock solution 5-25 part, hirudin 2-5 part.
2. wrinkle removal skin care skin whitener according to claim 1, it is characterised in that the concentration of described Glycyrrhiza glabra L. concentration stock solution is 30-40%, and its preparation method is as follows:
The first step: pulverized by Glycyrrhiza glabra L. raw material, puts in reaction vessel, soaks 4-6 hour, and the weight ratio of Glycyrrhiza glabra L. and water is 2:(10-15);
Second step: after Glycyrrhiza glabra L. is soaked 4-6 hour, heats to 70-80 degree, reacts 40-60 minute, cool down 25-40 minute, is again warming up to 70-80 degree and reacts 40-60 minute, centrifugation;
3rd step: taking centrate, to be concentrated into weight concentration be 30-40%, with decolorizing with activated carbon, adds 600-800 order filter cloth with sheet frame and filters, obtain Glycyrrhiza glabra L. concentration stock solution.
3. wrinkle removal skin care skin whitener according to claim 1, it is characterised in that described rose extract is 5-7 part.
4. wrinkle removal skin care skin whitener according to claim 1, it is characterised in that described hirudin is natural hirudin lyophilized powder.
5. wrinkle removal skin care skin whitener according to claim 1, it is characterised in that rose essence 1-1.5 part can also be added.
6. wrinkle removal skin care skin whitener according to claim 1, it is characterised in that vitamin E2-4 parts can also be added.
7. wrinkle removal skin care skin whitener according to claim 1, it is characterised in that collagen protein polypeptide 3-10 part can also be added.
8. wrinkle removal skin care skin whitener according to claim 1, it is characterised in that the concentration of described Flos Rosae Rugosae concentration stock solution is 30-40%, and its preparation method is as follows:
The first step: pulverized by Flos Rosae Rugosae, puts in reaction vessel, soaks 4-6 hour, and the weight ratio of Flos Rosae Rugosae and water is 2:(10-15);
Second step: after Flos Rosae Rugosae is soaked 4-6 hour, heats to 70-80 degree, reacts 40-60 minute, cool down 25-40 minute, is again warming up to 70-80 degree slowly and reacts 40-60 minute, centrifugation;
3rd step: taking centrate, to be concentrated into weight concentration be 30-40%, with decolorizing with activated carbon, adds 600-800 order filter cloth with sheet frame and filters, obtain Flos Rosae Rugosae concentration stock solution.
9. the preparation method of wrinkle removal skin care skin whitener according to claim 1, it is characterised in that in turn include the following steps:
The first step: Glycyrrhiza glabra L. stock solution is placed in container, batch production other Ingredients Weight except glycerol and edible food raw juice white vinegar is calculated by formula proportion, first rose extract or Flos Rosae Rugosae concentration stock solution are slowly added in Glycyrrhiza glabra L. stock solution, after stirring 5-10 minute, again natural hirudin lyophilized powder is added, stir 5-10 minute, then after adding vitamin C and other composition, stir 15-20 minute, obtain wrinkle removal skin care skin whitener intermediate.
Second step: glycerol is calculated batch quantity produced by formula proportion and is placed in container, the quantity that edible food raw juice white vinegar batch produces is calculated again by formula proportion, then edible food raw juice white vinegar is slowly added in glycerol container, stirs 10-15 minute, obtain glycerol vinegar mixed liquor.
3rd step: glycerol vinegar mixed liquor is placed in container, then the wrinkle removal skin care skin whitener intermediate first step obtained joins in glycerol vinegar mixed solution container, mix and blend 10-15 minute, obtains wrinkle removal skin care skin whitener.
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| Application Number | Priority Date | Filing Date | Title |
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| CN201610029026.8A CN105662944B (en) | 2016-01-16 | 2016-01-16 | Tender skin whitening lotion of anti-wrinkle and preparation method thereof |
Applications Claiming Priority (1)
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| CN105662944B CN105662944B (en) | 2018-12-28 |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107308099A (en) * | 2017-08-15 | 2017-11-03 | 广西壮族自治区药用植物园 | Leech ultra micro powder cosmetic of anti-wrinkle whitening and preparation method thereof |
| CN107510619A (en) * | 2017-09-06 | 2017-12-26 | 深圳肽之妃科技有限公司 | A kind of complex polypeptide facial mask and preparation method thereof |
| CN107854326A (en) * | 2017-12-19 | 2018-03-30 | 乳山寰海生物科技有限公司 | A kind of hirudin moistens face moisturizing maintenance Essence |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103006511A (en) * | 2012-12-21 | 2013-04-03 | 山东侨牌集团有限公司 | Hirudin skin-whitening moisture-keeping conditioning cream and production process thereof |
| CN105125474A (en) * | 2015-09-22 | 2015-12-09 | 夏放军 | Essential toner and preparation method thereof |
| CN105147559A (en) * | 2015-09-25 | 2015-12-16 | 夏放军 | Skin cream and preparing method thereof |
-
2016
- 2016-01-16 CN CN201610029026.8A patent/CN105662944B/en active Active
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103006511A (en) * | 2012-12-21 | 2013-04-03 | 山东侨牌集团有限公司 | Hirudin skin-whitening moisture-keeping conditioning cream and production process thereof |
| CN105125474A (en) * | 2015-09-22 | 2015-12-09 | 夏放军 | Essential toner and preparation method thereof |
| CN105147559A (en) * | 2015-09-25 | 2015-12-16 | 夏放军 | Skin cream and preparing method thereof |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107308099A (en) * | 2017-08-15 | 2017-11-03 | 广西壮族自治区药用植物园 | Leech ultra micro powder cosmetic of anti-wrinkle whitening and preparation method thereof |
| CN107510619A (en) * | 2017-09-06 | 2017-12-26 | 深圳肽之妃科技有限公司 | A kind of complex polypeptide facial mask and preparation method thereof |
| CN107510619B (en) * | 2017-09-06 | 2020-11-24 | 深圳肽之妃科技有限公司 | Composite polypeptide mask and preparation method thereof |
| CN107854326A (en) * | 2017-12-19 | 2018-03-30 | 乳山寰海生物科技有限公司 | A kind of hirudin moistens face moisturizing maintenance Essence |
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| Publication number | Publication date |
|---|---|
| CN105662944B (en) | 2018-12-28 |
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