CN105662944B - Tender skin whitening lotion of anti-wrinkle and preparation method thereof - Google Patents
Tender skin whitening lotion of anti-wrinkle and preparation method thereof Download PDFInfo
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- CN105662944B CN105662944B CN201610029026.8A CN201610029026A CN105662944B CN 105662944 B CN105662944 B CN 105662944B CN 201610029026 A CN201610029026 A CN 201610029026A CN 105662944 B CN105662944 B CN 105662944B
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
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- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
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- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
- A61K8/65—Collagen; Gelatin; Keratin; Derivatives or degradation products thereof
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- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/67—Vitamins
- A61K8/676—Ascorbic acid, i.e. vitamin C
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- A—HUMAN NECESSITIES
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- A61K8/67—Vitamins
- A61K8/678—Tocopherol, i.e. vitamin E
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- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
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- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/02—Preparations for care of the skin for chemically bleaching or whitening the skin
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- A—HUMAN NECESSITIES
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Abstract
The present invention provides a kind of tender skin whitening lotion of anti-wrinkle, based on parts by weight, including following ingredient: 20-40 parts of glycyrrhiza glabra concentration stock solution, 30-50 parts of glycerol, 15-30 parts of edible food raw juice light-coloured vinegar, 5-10 parts of vitamin C, rose extract or 5-25 parts of rose concentration stock solution, 2-5 parts of hirudin.The tender skin whitening lotion of the anti-wrinkle being capable of anti-wrinkle, tender skin, whitening.
Description
Technical field
The present invention relates to makeup technical fields, and in particular to a kind of tender skin whitening lotion of anti-wrinkle and preparation method thereof.
Background technique
The scientist (D.Hamam) of Britain in 1956 has found that free radical is the arch-criminal for leading to human senility for the first time.This
One discovery generates sensation in the world, produces tremendous influence to the development of the mankind.Damage of the free radical to human body is human body
The basic reason of aging, body surface is arrived in reflection indirectly, and phenomenon is exactly: first is that dry skin；Second is that skin of face relaxation after
And generate wrinkle；Third is that pore is coarse；Fourth is that facial colour spot；Fifth is that senile plaque；Sixth is that forming acne, dark sore；Seventh is that skin mistake
It is quick；Eighth is that intensely dark damp blackening of skin etc. brings huge damage to the skin of human body.
Frequent exposure is under the sun, the cell of melanin in meeting human activin, and accelerates synthesis of melanin, and here it is be assorted
Emphasize the reason of summer will carry out sun-proof work.There are also undesirable living habits, can also melanin be enabled to increase.With the age
Increase, melanin catabolic enzyme ability reduces, it is easier to form color spot.Human body generates and the ability of metabolism melanin is in certain
State balance among, this balance maintains the relatively stable of human body complexion, once melanin increases, the colour of skin will become
It is black.
Melanin is high-molecular biologic pigment, and the starting material of Skin Cell " production " melanin is tyrosine, tyrosine
It is a kind of amino acid very common in human body, in cell melanosome, tyrosine is more by generating DOPA after tyrosinase catalysis
DOPA quinone is formed after bar dehydrogenation, and is rearranged into 5, and 6 oxyindoles are mutually tied after indoles polymerization with the intracorporal structural proteins of melanocyte
Conjunction forms melanoprotein, melanoprotein namely the melanin that we usually say.
Enzyme (enzyme), also someone is known as ferment, is synthesized by various active protein substance, plays height to its specific substrate
Imitate the protein of catalytic action, also known as biocatalyst.Various chemical reactions are nearly all under the catalysis of enzyme in organism
It carries out.Enzymatic reaction has high catalytic efficiency, usually 107-1020 times higher than uncatalyzed reaction.But the catalysis of enzyme
Activity is also by various regulations.Enzyme has the specificity of height to substrate, and a kind of enzyme acts only on a kind of compound or certain
Chemical bond, to promote certain chemical change, and generate certain product, this phenomenon is also referred to as the specific or single-minded of enzyme
Property (specificity).Skin color mainly determines by the content of melanin in skin, the biology of melanin in melanocyte
Synthesis is a succession of oxidation reaction by enzymatic.Tyrosinase is the Major Enzymes of synthesis of melanin, in the multiple of synthesis process
It plays a crucial role in reaction step.
The mechanism of catalytic reaction of tyrosinase has always been concerned with, it is believed that only one double-core copper of tyrosinase
Point is activated, also it is believed that at least there are two different active sites in tyrosinase.Regardless of its mechanism of action, junket
Propylhomoserin enzyme is the key enzyme of melanogenesis, rate-limiting enzyme, and this point is not query.The activity of tyrosinase not only determines melanocyte
The characteristic mark of rate or the melanocyte differen-tiation maturation of synthesis, experiment also demonstrates tyrosinase activity and melanocyte closes
It is positively correlated at amount and is, activity change can cause dyschromicum skin disease such as chloasma, this is also that everybody spends great effort
The reason of tyrosinase activity activation is with inhibiting is studied, if can successfully, safely inhibit tyrosinase activity, whitening
Nti-freckle can be realized.
There must be copper ion participation in the reaction process of the catalytic tyrosine generation melanin of tyrosinase, this is one non-
Often important feature, meanwhile, reaction also needs oxygen radical to participate in.From this sense, tyrosinase is a kind of cupric need
Oxygenase.Skin adjustment mechanism accurately has some idea of herein, the generating process of melanin, in fact and oxygen radical self is clear
Except process.The reaction step that its melanin is formed are as follows:
1. by the tyrosinase of cupric, in the presence of oxygen radical, catalysis oxidation tyrosine generates DOPA, this
It is very slow that step reaction starts progress, but reacts and accelerate after DOPA is formed；
2. DOPA is changed into DOPA quinone under tyrosinase catalysis, there are two types of Consumptions for DOPA quinone, the first continues to turn
Become melanocyte, second and cysteine are changed into pheomelanin after interacting, and pheomelanin is more of light color than melanocyte.In melanin
It, can be by inhibiting tyrosinase activity or each blocking reaction in the reaction chain subtract in biosynthetic process
The synthesis of few melanin, this is one of the Basic Mechanism of current whitening and freckle-removing product formula design.Melanin is in skin epidermis
Interior uniform excess deposition, the colour of skin will blackening, melanin part excess deposition is to form freckle, the cardinal principle of chloasma.Junket
Propylhomoserin enzyme plays a crucial role in multiple reaction steps of melanin synthesis process, is key enzyme, the rate-limiting enzyme of melanin production.
Tyrosine is converted into DOPA by tyrosinase, and DOPA is both the raw material of synthesis of melanin in human body, and is closed
At adrenergic raw material, adrenaline is a kind of very important hormone in human body, so tyrosinase cannot be destroyed, but
It can try every possible means to inhibit its activity.The inhibition of enzymatic activity belongs to biochemical scope, all to reduce enzyme in biochemistry
Promote reaction speed, but the substance of enzyme molecule deactivation is not caused to be referred to as enzyme inhibitor, the effective object of enzyme, namely " former material
Material ", Biochemical Nomenclature is known as substrate.Tyrosinase catalysis tyrosine generates in the enzymatic reaction of melanin, and tyrosine is exactly
Substrate.Inhibiting effect is divided into can not retroactive inhibition and reversible inhibition two major classes.
The Irreversible inhibition of enzyme refers to the essential group covalent bond of inhibitor and enzyme molecule, thus inhibitory enzyme activity,
And enzymatic activity cannot be restored using straightforward procedures such as dialysis.Can not retroactive inhibition include specificity inhibit and non-specific inhibition.With
The inhibitor that non-covalent bond causes enzymatic activity to reduce in conjunction with enzyme molecule invertibity claims reversible inhibitor, reversible inhibition point
For several types such as competitiveness, Noncompetition inhibitions.
1. Reverse transcriptase: inhibitor with substrate competition in conjunction with the same activated centre of enzyme, to disturb enzyme and bottom
The combination of object reduces the catalytic activity of enzyme, and competitive inhibitor is often the substrate analogue or reaction product of enzyme；Inhibitor
And the binding site and substrate of enzyme are identical as the binding site of enzyme；Inhibitor concentration is bigger, then inhibiting effect is bigger；
2. Noncompetition inhibition: noncompetitive inhibitor both can in conjunction with enzyme, can also in conjunction with enzyme, substrate complex,
Making the catalytic activity of enzyme reduces, and substrate and inhibitor are separately combined with the different parts of enzyme, noncompetitive inhibitor pair
The combination of enzyme-to-substrate without influence, therefore the change of concentration of substrate on inhibition level without influence.
Currently, being formulated design aspect in whitening and freckle-removing product, it is reversible that tyrosinase activity, which inhibits commonplace mechanism,
Competitive type.
The essence that competitive inhibits is: adding a kind of chemicals, structure and substrate are much like, allow enzyme " takeing for "
It is substrate and its combination, it is catalyzed, the result is that catching at shadows.Tyrosinase is to start to urge using tyrosine as substrate
Change, adds a kind of substance of structure and tyrosine relatively, tyrosinase is simultaneously combined tyrosine and additive,
Catalysis, the result is that tyrosine is converted into melanin, additive is not acted on, and net result is practical function in the enzyme quantity of tyrosine
Few, the melanin amount of production is naturally just few.This mechanism is easier to understand, chemically can also tentatively push away in structure
It surveys, screening whitening additive, using being easier.Quinhydrones is an example of competitive inhibiting mechanism application, tyrosine
Precursor structure be a phenyl ring and a hydroxyl, quinhydrones chemical structure is hydroquinone (phenyl ring and two hydroxyls), knot
Structure is close, and quinhydrones and tyrosine with tyrosinase ining conjunction with, are generated and competed, as a result quinhydrones consumes a part of tyrosinase simultaneously.
At present with more whitening additive arbutin is also to belong to competitive inhibiting mechanism.
Natural plant kind cosmetics are the development trend of current China's cosmetics research and development, and are represented by plant extract fine Huawei
Chinese herbal medicine be then a kind of fashion of functional cosmetics.Natural Chinese medicinal herb class cosmetics, raw material is extensive, ingredient is natural, product peace
Entirely, conducive to environmental protection and meet the theory of sustainable development, and attract one of the product advantage of consumer.Thus it is necessary to develop
A kind of tender skin whitening lotion of anti-wrinkle caters to pursuit of the new period people to beauty.
Summary of the invention
A kind of tender skin whitening lotion of anti-wrinkle is provided it is an object of the present invention to overcoming the above-mentioned insufficient of the prior art, it should
The tender skin whitening lotion of anti-wrinkle being capable of anti-wrinkle, tender skin, whitening.
The second object of the present invention is to provide the preparation method of the tender skin whitening lotion of above-mentioned anti-wrinkle.
The tender skin whitening lotion of anti-wrinkle of the present invention, based on parts by weight, including following ingredient:
20-40 parts of glycyrrhiza glabra concentration stock solution, 30-50 parts of glycerol, 15-30 parts of edible food raw juice light-coloured vinegar,
5-10 parts of vitamin C, rose extract or 5-25 parts of rose concentration stock solution, 2-5 parts of hirudin.
Wherein the rose extract is 5-7 parts preferred.
Wherein the hirudin is natural hirudin freeze-dried powder.
1-1.5 parts of flavoring rose essence can also be added in the tender skin whitening lotion of anti-wrinkle of the present invention.
2-4 parts of vitamin E can also be added in the tender skin whitening lotion of anti-wrinkle of the present invention.
3-10 parts of collagen polypeptide can also be added in the tender skin whitening lotion of anti-wrinkle of the present invention.
Wherein the concentration of the glycyrrhiza glabra concentration stock solution is 30-40%, the preparation method is as follows:
Step 1: glycyrrhiza glabra raw material is crushed, puts in reaction vessel, soak in water 4-6 hours, glycyrrhiza glabra
Weight ratio with water is 2: (10-15)；
Step 2: being heated up to 70-80 degree after glycyrrhiza glabra is impregnated 4-6 hours, react 40-60 minutes, cooling 25-40
Minute, it is warming up to 70-80 degree slowly again and reacts 40-60 minutes, centrifuge separation；
Step 3: taking centrate to be concentrated into weight concentration is 30-40%, with decolorizing with activated carbon, with sheet frame plus 600-
The filtering of 800 mesh filter cloths, obtains glycyrrhiza glabra concentration stock solution.
Wherein the rose concentration stock solution concentration is 30-40%, the preparation method is as follows:
Step 1: rose is crushed, puts in reaction vessel, soak in water 4-6 hours, the weight ratio of rose and water
It is 2: (10-15)；
Step 2: being heated up to 70-80 degree after rose is impregnated 4-6 hours, react 40-60 minutes, it is 25-40 minutes cooling,
It is warming up to 70-80 degree slowly again to react 40-60 minutes, centrifuge separation；
Step 3: taking centrate to be concentrated into weight concentration is 30-40%, with decolorizing with activated carbon, with sheet frame plus 600-
The filtering of 800 mesh filter cloths, obtains rose concentration stock solution.
The preparation method of the tender skin whitening lotion of anti-wrinkle of the present invention, in turn includes the following steps:
Step 1: glycyrrhiza glabra stoste is placed in container, by formula rate calculate batch production with remove glycerol with
It is sweet to be first slowly added to light fruit by other Ingredients Weights other than edible food raw juice light-coloured vinegar for rose extract or rose concentration stock solution
In the liquid of grassland, after stirring 5-10 minute, then natural hirudin freeze-dried powder is added, stirring 5-10 minutes, then plus vitamin C and its
After its ingredient, stirs 15-20 minutes, obtain the tender skin whitening lotion intermediate of anti-wrinkle.
Step 2: glycerol is placed in container by the quantity that formula rate calculates batch production, then press formula rate
Edible food raw juice light-coloured vinegar, is then slowly added in glycerol container by the quantity for calculating the production of edible food raw juice light-coloured vinegar batch, stirs
10-15 minutes, obtain glycerol vinegar mixed liquor.
Step 3: glycerol vinegar mixed liquor is placed in container, then the tender skin whitening lotion intermediate of the anti-wrinkle that the first step is obtained
It is added in glycerol vinegar mixed solution container, is mixed 10-15 minutes, obtains the tender skin whitening lotion of anti-wrinkle.
Step 4: by the tender skin whitening lotion terminal sterilization in bulk of anti-wrinkle, then Packaging Bottle high-temperature sterilization, the tender skin whitening lotion inspection of anti-wrinkle
It surveys, every bottle of 100ml is filling, storage.
The tender skin whitening lotion sphere of action of anti-wrinkle of the present invention: the intensely dark pool of skin, whitening realize that fair and clear skin, disappear eye of dispelling
Angle wrinkle, crow's feet, forehead line, the functions of removing chloasma that disappears, butterfly macules, sunburn, cyasma (pregnant spot), chorioplaque, blackspot, freckle,
Sunburn, age spot, mercury spot, sweat stain, blood spots, endocrine disorder spot, water deficient spot, cosmetic chemistry injure spot, Environmental Chemistry
The melanin of all kinds of color spots such as smudging and difficult and complicated cases spot is eliminated and desalinates all kinds of color spots, improves skin texture at all, quickly go
Black whitening, quickly eliminating stain, anti-aging, tender skin beauty treatment, moisturizing.
The application method of the tender skin whitening lotion of anti-wrinkle of the present invention is as follows: 1, air-drying after being cleaned skin with warm water；2, by bottle
3 to 5 drop of drop is crossed in the palm of the hand, be put on after repeatedly soft and loop on the face, then the palm of the hand gently pats face to fully absorbing again, face
It brightens and tenderizes；3, adhere to once in the morning and once at night daily.
The tender skin whitening lotion action principle of anti-wrinkle is as follows:
Bioactive small molecule is only one of the seventy points of traditional plant extraction essential ingredient in the tender skin whitening lotion of anti-wrinkle, more
It is easy through human skin basal layer, is absorbed with half an hour after, major function effect is the microcirculation by improving skin
And nutrition condition, activating microcirculation and removing stasis medicinal, balance pigment, it fundamentally solves skin moisture-keeping, the various fleckiness of wrinkle-chasing, the flat tender skin of wrinkle and supports
Face whitening problem keeps skin smooth fine and smooth, reaches ideal effect within 30 days.
Action principle removes capillary metabolism and residual waste rubbish step 1: rapid osmotic skin
The tender skin whitening lotion main ingredient hirudin of anti-wrinkle, rose active composition rapid osmotic skin, act on skin texture layer, deep
Enter pore bottom, improve capillary of skin permeability, removes the fleshes such as capillary metabolism and residual waste rubbish, carbon dioxide
Dirt toxin in skin makes the capillary of siltation be improved dredging, and facial microcirculation restores normally, and black eye is gradually desalinated and disappears
It loses.
Composition hirudin in the tender skin whitening lotion of anti-wrinkle, the single chain polypeptide being made of 65-66 amino acid, molecular weight are
7000 dalton can help other nutriments to penetrate to the skin rapidly deep layer, are easily absorbed and utilized by Skin Cell, hirudin can
Blood viscosity is reduced, blood flowing speed is accelerated, dredges capillary, improves blood vessel microcirculation, promotes skin metabolism, makes
Cell obtains sufficient nutrient, and delay skin aging promotes the self-regeneration of chrotoplast, makes the hair that skin is fine and smooth, contraction is coarse
Especially there is unique beauty in hole to acne, acne, redness, facial pigmentation deposition, Skin indentation reparation, whitening, promotion cytothesis
Hold skin-care effect.
Action principle wakes up cell viability step 2: quickly eliminate scytitis
Scytitis is quickly eliminated, melanin production root is first turned off, reduces tyrosinase activity, it is living to wake up cell
Power optimizes the living environment of cell, reinforces eye part skin to extraneous resistance and tolerance level, makes eye skin moisturizing,
Deep layer white eye skin only.
With advancing age, lipid peroxide (the also known as rust of human body) can be continuously increased in human body, and cause cell
Function can not be played normally.When cylinder super-oxidation lipid is excessive, it can be combined with intracorporal substance, generate and have virose peroxide
Substance.If this phenomenon occurs on the skin, the metabolic capabilities of skin being made to decline, and easily waste is made to accumulate in skin
Surface forms senile plaque, and the tension reduction of skin or elasticity can also reduced, increases the wrinkle of skin and becomes loose, and divides
If secreting the sebaceous glands of grease and the sweat gland function decline of perspiration, skin will lose moist ingredient, aging in advance.
Composition edible food raw juice vinegar, hirudin in the tender skin whitening lotion of anti-wrinkle, force action have it is very strong sterilization, it is antibacterial
Ability.To Bacillus bacterium, Micrococcus bacterium, Pseudomonas fluorescens and henry Pian Shi coccus, staphylococcus aureus, mouse typhus
Detection of Salmonella and pathogenicity coliform etc. can kill inhibition breeding completely.As long as acetate concentration more than 122 mg/litres, as long as
Half a minute can kill completely staphylococcus, Salmonella enteritidis, shigella sonnei, secondary dissolved oxygen vibrios, to cause of disease coliform,
Only need half a minute that can all kill.
Research it is also shown that edible food raw juice vinegar to first kind streptococcus, blocked coccus, Diplococcus pneumopniae, staphylococcus albus and
The respiratory tracts microorganism such as influenza virus has deactivation, 30 minutes after smoking indoors, in addition to first streptococcus has individual colonies, and discovery
Remaining is killed entirely.Test kills corynebacterium diphtheriae and the scorching virus of meningococal meningitis, morbilli, cheek line it is also shown that vinegar has
Effect.For the various bacterias such as Pseudomonas aeruginosa, trichophyte, fungi, vinegar can also have very strong killing ability.Edible food raw juice vinegar
In the compounds such as acetic acid, lactic acid, amino acid, glycerol and aldehydes, have soft stimulation to the skin of people, blood vessel can be made to expand
, increase skin blood circulation, keeps skin smooth.On tcm clinical practice and in folk remedy, all vinegar is widely used for preventing and treating
Surgery, dermatology a variety of diseases, and achieve preferable effect.
Action principle is anti-oxidant step 3: efficient water lock, moisturizing
Glycerol, vitamin C are " spring in youth " by scientist's good reputation, as one of most important natural, and
Moisture content in draw air can also lock the moisture content in skin to skin moisture-keeping, from it is interior reinforce skin natural protective barrier,
It is a kind of critically important vasodilator and anticoagulant, main function is anti-oxidant, protects body cell from the poison of free radical
Evil protects the skin from the injury of ultraviolet light and pollution, reduces the deposition of scar and pigment, improves lipid-metabolism, prevents coronary disease
Disease, atherosclerosis, prevention and treatment varication, prevention of inflammation dermatoses, baldness, prevention hemolytic anemia are protected
Shield red blood cell is allowed to not allow easily rupturable, prophylactic treatment thyroid disease, improves blood circulation, and the solidification of anti-Hemostatic Oral Liquid reduces spot
The generation of line tissue, the wrinkle resistant triple beautiful effects of spot-removing beautifying face, moisture-locking, moisturizing, skin-active.
Action principle is step 4: whitening, tender skin
Whitening, tender skin are the themes of the tender skin whitening lotion action and efficacy of anti-wrinkle, are one of the compositions in the tender skin whitening lotion of anti-wrinkle,
Glycyrrhiza glabra is referred to as " whitening gold ", it can promote cell metabolism, and enhancing skin resists uv damage, makes skin extensive
Multiple fair and clear transparent skin quality.Glycyrrhiza glabra stoste inhibition tyrosinase oxidation activity with super strength and liposome is prevented to be oxidized
Function.Tyrosinase is ingredient necessary to synthetic melanin, and glycyrrhiza glabra stoste can act on eye circumference epidermal basal
The melanocyte of layer inhibits arch-criminal-tyrosinase activity of melanin deposition, hinders melanin to be formed, while inhibiting rouge
Matter peroxidating promotes rapid division, the proliferation of neonatal cell, and the metabolism of extra melanin, eliminates eye circumference skin and produce in acceleration bodies
Raw melanin deposition and color spot, reaches and eats up melanin, restores the effect of the eye circumference colour of skin.
The tender skin whitening lotion of anti-wrinkle, which uses, automatically removes the association principle of melanin, to allow in the tender skin whitening lotion of anti-wrinkle
Effective ingredient glycyrrhiza glabra fixed (Glabridin) and glycyrrhiza glabra are plain (Glabrene), and amino acid locks activity, to avoid black
The generation of pigment has contained that source occurs for melanin.Melanin effect is sneered in addition, also actively gulping down in the tender skin whitening lotion of anti-wrinkle,
Achieve the effect that tender skin whitening again to repair skin melanin accumulation damaged tissues.
Melanin is to be transformed by tyrosine (one kind of amino acid), but tyrosine becomes one item of melanin demand
Part: being exactly the participation of tyrosinase, if this enzyme cannot be synthesized, melanin cannot be generated, in the tender skin whitening lotion of anti-wrinkle
Composition tool is anti-oxidant and restores effect, can lock the activity of tyrosinase, be allowed to lose efficiency.In addition, the tender skin whitening lotion of anti-wrinkle
Effective ingredient can accelerate the absorption of free radical, heat-clearing is soothing the liver, assists the swollen removing toxic substances waste discharge of liver, promotes repair of damaged tissues, enhancing
Hepatic and renal function.The tender skin whitening effect of anti-wrinkle is just seen after 2 days usually using the tender skin whitening lotion of anti-wrinkle.
The tender skin whitening lotion time effect of anti-wrinkle is as follows:
With advancing age, in the sear and yellow, lose one's charm with years, there is wrinkle in skin, fleckiness, obscure, this is to be difficult to
The process avoided, but the tender skin whitening lotion of anti-wrinkle can allow you to realize the hope of whitening and softening skin allows you to reappear youth, bright
Beautiful, pale, elastic skin.
Using the preceding obscure jaundice of skin color, dry skin water shortage has pigementation and wrinkle, acne print, fleckiness, skin
Drying has microgroove, and water content is low, and water loss speed is fast.
It uses effect after the tender skin whitening lotion of anti-wrinkle 2 days: obviously experiencing the tender skin whitening lotion of anti-wrinkle to the reparation and taste of skin
It mends, skin moisture increases, and no longer greasy, dark sore is reduced；Skin lightening degree averagely improves 2-3 degree, slightly whiter than before using, and touches
Shi Mingxian feels soft and smooth.
Use effect after the tender skin whitening lotion of anti-wrinkle 7 days: blackspot, acne print, wrinkle are obviously thin out, and skin water lock ability is reinforced,
Skin lightening degree averagely improves 3-5 degree, fine and smooth soft, and skin ratio is attenuated using preceding significantly bleach.Whitening factor rapid osmotic
To deep skin, melanin production root is cut off, melanin is cracked, uses obvious fine and smooth, glossy, the skin of skin after a period
Highlight two colorations.
Use effect after the tender skin whitening lotion of anti-wrinkle 15 days: skin is fine and smooth, compact, wrinkle, eye pouch, blackspot, acne print, dark sore base
This disappearance, skin resists the ability of environmental stimuli and self-recovery ability is significantly reinforced, and skin lightening degree averagely improves 5-6 degree.
Ruddy, tender white, coloured and dazzling, the tender white state of young healthy is presented in whole skin.
Use effect after the tender skin whitening lotion of anti-wrinkle 30 days: hirudin, rose active composition act on skin texture layer, go deep into pore
Bottom, removes dirt in skin, residue and surface layer pigment rubbish in pore, and the effect of early period will obtain comprehensive solidification and mention
It rises, whitening skin children is tender, gentle and demure moving, high resilience and gloss, and melanocyte metabolism restores balance.
The primary raw material medicine that the present invention uses is described as follows:
(1) edible food raw juice light-coloured vinegar:
[National Standard of the People's Republic of China] making vinegar (GB 18187-2000)
Research it is also shown that edible food raw juice vinegar to first kind streptococcus, blocked coccus, Diplococcus pneumopniae, staphylococcus albus and
The respiratory tracts microorganism such as influenza virus has killing effect.
Test also shows the effect for having killing to corynebacterium diphtheriae and meningococal meningitis, morbilli, cheek line inflammation virus.It is right
In the various bacterias such as Pseudomonas aeruginosa, trichophyte, fungi, vinegar can also have very strong killing ability.
The compounds such as acetic acid, lactic acid, amino acid, glycerol and aldehydes in edible food raw juice vinegar, have the skin of people soft
Stimulation can distend the blood vessels, and increase skin blood circulation, make skin smooth, tender skin, skin care effect.
(2) glycyrrhiza glabra:
Glycyrrhiza glabra, also known as, licorice, licorice perennial herb, root is sturdy with rhizomes, diameter 0.5-3cm, root skin
Brown, the inside yellow have sweet taste.Stem is upright, multi-branched, and high 0.5-1.5m, base portion band is wooden, close by faint yellow flakey gland point
With white pubescence, has a rib when young, have short setiform body of gland sometimes.Seed dirty-green, smooth, kidney shape, about 2 millimeters of diameter.Flower
Month phase 5-6, the fruiting period 7-9 month.
Root, the rhizomes histocyte of glycyrrhiza glabra are interior there is the very strong depigmentation of skin of antioxygenic activity, lighten the stain
Functional component, and be main component, i.e., glycyrrhiza glabra plain (Glabrene) and glycyrrhiza glabra are fixed (Glabridin).Glycyrrhiza glabra
Fixed, molecular formula C20H2004, molecule relative mass 324.28 is colourless powder body, not soluble in water, and in methanol, ethyl alcohol and second
It is dissolved in ether equal solvent.Glycyrrhiza glabra is fixed and many components of cosmetics are fully inclusive and equitable, and compatibility is good, and it is anti-will not to generate Antagonism
It answers.
(3) glycerol:
Content is revised and enlarged in [Chinese Pharmacopoeia] 2010 editions Chinese Pharmacopoeia revisions, and glycerine is colourless sweet clear and bright thick liquid, nothing
It is smelly, have warm sweet taste, be commonly called as glycerol, moisture can be absorbed from air, can also absorb hydrogen sulfide, hydrogen cyanide and sulfur dioxide.Indissoluble
In benzene, chloroform, carbon tetrachloride, carbon disulfide, petroleum ether and oils.
(4) vitamin C:
Vitamin C (also known as ascorbic acid) is in close relations with human health, is that a kind of important and special water soluble vitamin is raw
Element has molecular structure the simplest, and physicochemical property is most unstable, and human body daily requirement amount is maximum, and diet distribution is concentrated the most
Etc. special natures, in terms of maintaining human normal function have a variety of important roles.
Vitamin is a kind of general name for maintaining low-molecular-weight organic compound necessary to body normal physiological function.It is public at present
The vitamin recognized mainly has 13 kinds, is visually known as " The Heroic Ones " of vitamin family.In vitamin family, vitamin
C is more special, has a variety of specificity and a series of physiological functions, has to human health status and food value larger
Influence.Since vitamin C has effects that antiscorbutic, and property and apparent tart flavour with organic acid, it is also known as anti-
Bad hematic acid (ascorbicacid).
(5) rose:
2010 editions Chinese Pharmacopoeias, alias；It hovers and spends, written flower, lake flower, dahurian rose flower, pierces rose chrysanthemum.Belong to Rosales, rosaceae
Machaka, branch bar spininess thorn, imparipinnate leaf, 5~9, leaflet, ellipse has side thorn.Petal obovate, polyphyll to half
Polyphyll, flower have aubergine, white, the fruiting period 8-9 month, oblate spheroid.When rose is as crops, flower is mainly used for food and mentions
Essence attar of rose is refined, attar of rose is applied to the industry such as cosmetics, food, fine chemistry industry.Efficacy effect: promoting qi circulation and removing obstruction in the collateral and blood, only
Bitterly, stomachache due to emotional depression and the hyperactive liver-qi attacking the stomach, deficiency of food evil of vomitting, irregular menstruation, the pain of injury caused by falling and tumbling are used for.
(6) hirudin:
2010 editions Chinese Pharmacopoeias, hirudin (hirudin) are to have extracted a variety of work in leech (Leech) and its salivary gland
Property ingredient in a kind of most significant and most studied ingredient of activity, the small molecule egg that it is made of 65-66 amino acid
White matter (polypeptide).Hirudin has extremely strong inhibiting effect to fibrin ferment, is that strongest fibrin ferment found so far is naturally special
Different inhibitor.
(7) vitamin E:
Vitamin E (Vitamin E) is a kind of liposoluble vitamin, and hydrolysate is tocopherol, is most important anti-
One of oxidant.[1] it is dissolved in the organic solvents such as fat and ethyl alcohol, it is not soluble in water, heat, acid are stablized, it is unstable to alkali, to oxygen
Sensitivity, it is insensitive to heat, but Vitamin E activity is substantially reduced when frying.Tocopherol can promote sex hormone to secrete, and make man's sperm
Vigor and quantity increase；Increase woman's female hormone concentration, improve fecundity, prevention of miscarriage, it may also be used for prevention and treatment male
Sterility, burn, frostbite, capillary hemorrhage, climacteric syndrome, beauty etc..
(8) collagen polypeptide:
This word of polypeptide Peptide is from Greek π ε π τ óIt is derived, means " being digested ".Pass through
It to collagen chain enzymatic hydrolysis, then extracts, becomes the Hydrolyzed Collagen of resolvability, saving has three-dimensional live
Three helical polypeptide structures of property.
Specific embodiment
Embodiment of the present invention is described in detail below in conjunction with embodiment, but those skilled in the art will
Understand, the following example is merely to illustrate the present invention, and should not be taken as limiting the scope of the invention.
Table 1 is the Example formulations of the tender skin whitening lotion of anti-wrinkle of the present invention.Wherein glycyrrhiza glabra concentration stock solution and rose concentration
The concentration of stoste is 30%, and hirudin is natural hirudin freeze-dried powder.
Table 1
Glycyrrhiza glabra concentration stock solution used in above embodiments the preparation method is as follows:
Step 1: glycyrrhiza glabra raw material is crushed, put in reaction vessel, soak in water 4 hours, glycyrrhiza glabra and
The weight ratio of water is 2: 15；
Step 2: being heated up to 80 degree after glycyrrhiza glabra is impregnated 4 hours, react 40 minutes, it is 30 minutes cooling, again slowly
It is warming up to 80 degree to react 40 minutes, centrifuge separation；
Step 3: taking centrate to be concentrated into weight concentration is 30%, with decolorizing with activated carbon, with sheet frame plus 600 mesh mistakes
Filter-cloth filtering obtains glycyrrhiza glabra concentration stock solution.
Rose concentration stock solution used in above embodiments the preparation method is as follows:
Step 1: rose is crushed, puts in reaction vessel, soak in water 4 hours, the weight ratio of rose and water is
2:15；
Step 2: being heated up to 80 degree after rose is impregnated 4 hours, react 40 minutes, 30 minutes cooling, slow heating again
It is reacted 40 minutes to 80 degree, centrifuge separation；
Step 3: taking centrate to be concentrated into weight concentration is 30%, with decolorizing with activated carbon, with sheet frame plus 600 mesh mistakes
Filter-cloth filtering obtains rose concentration stock solution.
The tender skin whitening lotion of above embodiments anti-wrinkle the preparation method is as follows:
Step 1: glycyrrhiza glabra stoste is placed in container, by formula rate calculate batch production with remove glycerol with
It is sweet to be first slowly added to light fruit by other Ingredients Weights other than edible food raw juice light-coloured vinegar for rose extract or rose concentration stock solution
In the liquid of grassland, after stirring 5-10 minute, then natural hirudin freeze-dried powder is added, stirring 5-10 minutes, then plus vitamin C and its
After its ingredient, stirs 15 minutes, obtain the tender skin whitening lotion intermediate of anti-wrinkle.
Step 2: glycerol is placed in container by the quantity that formula rate calculates batch production, then press formula rate
Edible food raw juice light-coloured vinegar, is then slowly added in glycerol container by the quantity for calculating the production of edible food raw juice light-coloured vinegar batch, stirs
10 minutes, obtain glycerol vinegar mixed liquor.
Step 3: glycerol vinegar mixed liquor is placed in container, then the tender skin whitening lotion intermediate of the anti-wrinkle that the first step is obtained
It is added in glycerol vinegar mixed solution container, is mixed 10 minutes, obtains the tender skin whitening lotion stoste of anti-wrinkle.
Step 4: by the tender skin whitening lotion stoste terminal sterilization in bulk of anti-wrinkle, then Packaging Bottle high-temperature sterilization, the tender skin whitening of anti-wrinkle
Liquid detection, every bottle of 100ml is filling, storage.
Effect test:
(1) measurement of radicals scavenging effect:
It is respectively the concentration of mass volume ratio 1% at concentration by the sample preparation of previous embodiment with dimethyl sulfoxide, into
Row experiment below.
Take sample solution 2ml and concentration for diphenyl picryl phenylhydrazine (DPPH) solution (solvent of the solution of 100umol/L
It is for water) 2ml is first added in same tool plug test tube, shakes up, 30 minutes are stood at room temperature, using solvent as blank, in 517nm wavelength
Lower measurement sample absorbance.
Inhibiting rate: k%=[1- (Ai-Aj)/AC] × 100%
The absorbance of Ai:2mlDPPH solution+2ml sample solution
The absorbance of Aj:2ml sample solution+2ml solvent (i.e. dimethyl sulfoxide)
The absorbance of AC:2mlDPPH solution+2ml solvent (i.e. dimethyl sulfoxide)
Experimental result is shown in Table 2:
Table 2
| Inhibiting rate, % | |
| Embodiment 1 | 86.5 |
| Embodiment 2 | 85.5 |
| Embodiment 3 | 85.9 |
| Embodiment 4 | 86.8 |
| Embodiment 5 | 87.0 |
| Embodiment 6 | 89.9 |
| Embodiment 7 | 88.7 |
| Embodiment 8 | 89.9 |
| Embodiment 9 | 91.2 |
| Embodiment 10 | 90.9 |
| Embodiment 11 | 90.7 |
| Embodiment 12 | 91.5 |
The experimental results showed that the tender skin whitening lotion of anti-wrinkle of the invention can effectively inhibit the generation of free radical, and significant effect.
(2) inhibit B16 cell test in mouse melanin cell:
By B16 mouse melanin tumor cell with 1 × 105The density of a/ml be connected to diameter be 9cm culture dish, 37 DEG C,
5%CO2Under conditions of cultivate 2 days, abandon supernatant, be added filtration sterilization after sample solution 18-22ml, be then incubated for 3 days, abandon
The trypsin solution vitellophag 3min of 0.5ml mass percent 0.2% is added in supernatant, PBS washing, every hole, and every ware adds 2ml to tie up
It holds liquid and terminates digestion.After piping and druming mixes, every kind of concentration takes out 0.5ml and does cell count, remaining cell suspension with 2500r/min from
Heart 5min abandons supernatant, and NaoH solution is added in precipitating, and heating dissolves melanin, selects the enzyme linked immunological of 490nm wavelength
Absorbance value is surveyed on detector.
B16 cell inhibiting rate=(1- (drug hole absorbance+drug hole cell density)+(control wells absorbance value+right
According to hole cell density)) × 100%
Inhibit B16 cell test in mouse melanin cell, the results are shown in Table 3:
Table 3
Clinical test one:
(1) patient:
Selection screening 240 has the healthy population of freckle and spot on the face, and men and women is unlimited, is randomly divided into 12 groups, every group 10
People uses the tender skin whitening lotion of anti-wrinkle of embodiment 1-12 respectively.
(2) application method:
1, it is air-dried after being cleaned skin with warm water；2, bottle is crossed to 3 to 5 drop of drop in the palm of the hand, is put on face after repeatedly soft
On loop, then the palm of the hand gently pats face to fully absorbing again；3, adhere to once in the morning and once at night daily.Experimental period is 30 days.
The brightness of use front and back skin is measured (with color difference average value come table to every group of each subject using color difference meter
Show, color difference average value is bigger, shows that skin is brighter), and following standard is pressed, whitening freckle cream is observed to face's freckle and spot
Effect.
Evaluation criterion: effectively: spot, freckle obviously decline；Effective: spot and freckle slightly decline；It is invalid: unchanged.
Concrete outcome is shown in Table 4.
Table 4
As seen from the above table, the whitening spot-removing effect of experimental group is all fine.
Clinical test two:
Clinical dossier five:
A, Gong (one Chenzhou, the Hunan) age 48 years old
Spot type: born freckle
Use the time: 2 months
Effect comment: begin to use the tender skin whitening liquid product of 6 anti-wrinkle of the embodiment of the present invention in April, 2015, only used 2
A month, skin was just changed on the face, and originally I has a blackening on the face, yellowish-brown class, and than more serious, had used this product
Afterwards, blackening, chloasma have just desalinated many, and also this is original glossy for skin, flexible, because the relationship of working environment, out of office
The length of outer work, June one September part, skin tanning by the two moon reparations, and is restored to original gloss.
B, Zhang (Henan-Luohe) age 23 years old
Spot type: born freckle
Use the time: 8 months
Effect comment: beginning to use the tender skin whitening liquid product of 8 anti-wrinkle of the embodiment of the present invention in March, 2015, is interrupted using,
Using nearly 8 months, product effect was that have blackening, color spot on the face originally, and the intensely dark pool of skin is nonelastic, before spot on the face
It is substantially all without and feeling that skin is finer and smoother, also bleach, do not think dry, water shortage.
C, Mr. Wang's (Guangdong-Zhanjiang) age 29
Spot type: pigmentation spots
Use the tender 2 months skin whitening lotion time of wrinkling
Effect comment: born face is just yellow, and after more than 20 years old whens have gone to seabeach, spot just comes.In several years, tried much to protect
Skin product, DIY, laser, tartaric acid what, all ineffective, some take effect quickly, but one get sun once in a while, and spot is again long, and
And grow more.After begin to use the tender skin whitening liquid product of 10 anti-wrinkle of the embodiment of the present invention, initially several days, the edge of spot starts
Fuzzy to become smaller, using wrinkle tender skin whitening lotion 2 months, spot did not all have.
D, Mrs Lin (Sichuan-Chengdu) age 36 years old
Spot type: born freckle
Use the time: 4 months
Effect comment: it using before the tender skin whitening liquid product of 11 anti-wrinkle of the embodiment of the present invention, goes to try the light spot of laser, try
Later spot is really light, but soon returns with regard to rebound.Using tender skin whitening lotion general two weeks just again effect of wrinkling, those
Dot point substantially just it is light must not see, bulk color spot be also it is gradually unintelligible, skin also becomes pale glossy.4 months
Past, people youthen.
E, Mr. Li (Hunan-strain state) age 33 years old
Spot type: born blackening
Use the time: 2 months
Effect comment: begin to use the tender skin whitening liquid product of 12 anti-wrinkle of the embodiment of the present invention in April, 2014, use 15 days
Afterwards, skin is just changed on the face, is had a bulk of spot acne of blackening, especially back on the face originally than more serious, has been used this
After product, blackening, a bulk of spot acne of back has desalinated many, and spot acne disappears after 2 months, and skin is also more glossy than original, there is bullet
Property, it was repaired by 2 months, and be restored to original gloss.
Claims (5)
1. a kind of tender skin whitening lotion of anti-wrinkle, it is characterised in that based on parts by weight, including following ingredient: glycyrrhiza glabra concentration stock solution
20-40 parts, 30-50 parts of glycerol, 15-30 parts of edible food raw juice light-coloured vinegar, 5-10 parts of vitamin C, 5-25 parts of rose extract, leech
It is 2-5 parts plain, 2-4 parts of vitamin E, 3-10 parts of collagen polypeptide；
The concentration of the glycyrrhiza glabra concentration stock solution is 30-40%, and preparation method is as follows:
Step 1: glycyrrhiza glabra raw material is crushed, puts in reaction vessel, soak in water 4-6 hours, glycyrrhiza glabra and water
Weight ratio be 2:(10-15)；
Step 2: being heated up to 70-80 degree after glycyrrhiza glabra is impregnated 4-6 hours, react 40-60 minutes, it is 25-40 minutes cooling,
It is warming up to 70-80 degree again to react 40-60 minutes, centrifuge separation；
Step 3: taking centrate to be concentrated into weight concentration is 30-40%, with decolorizing with activated carbon, with sheet frame plus 600-800 mesh
Filter cloth filtering, obtains glycyrrhiza glabra concentration stock solution.
2. the tender skin whitening lotion of anti-wrinkle according to claim 1, it is characterised in that the rose extract is 5-7 parts.
3. the tender skin whitening lotion of anti-wrinkle according to claim 1, it is characterised in that the hirudin is natural hirudin freeze-drying
Powder.
4. the tender skin whitening lotion of anti-wrinkle according to claim 1, it is characterised in that be additionally added 1-1.5 parts of flavoring rose essence.
5. the preparation method of the tender skin whitening lotion of anti-wrinkle according to claim 1, it is characterised in that in turn include the following steps:
Step 1: glycyrrhiza glabra concentration stock solution is placed in container, by formula rate calculate batch production with remove glycerol with
Rose extract, is first slowly added in glycyrrhiza glabra concentration stock solution, stirs by other Ingredients Weights other than edible food raw juice light-coloured vinegar
After mixing 5-10 minutes, then natural hirudin freeze-dried powder is added, stirred 5-10 minutes, then plus vitamin C and other ingredients after, stir
It mixes 15-20 minutes, obtains the tender skin whitening lotion intermediate of anti-wrinkle；
Step 2: glycerol is placed in container by the weight that formula rate calculates batch production, then calculated by formula rate
Edible food raw juice light-coloured vinegar, is then slowly added in glycerol container by the weight of edible food raw juice light-coloured vinegar batch production out, stirs 10-15
Minute, obtain glycerol vinegar mixed liquor；
Step 3: glycerol vinegar mixed liquor is placed in container, then the tender skin whitening lotion intermediate of anti-wrinkle that the first step obtains is added
Enter into glycerol vinegar mixed solution container, is mixed 10-15 minutes, obtains the tender skin whitening lotion of anti-wrinkle.
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| CN107308099A (en) * | 2017-08-15 | 2017-11-03 | 广西壮族自治区药用植物园 | Leech ultra micro powder cosmetic of anti-wrinkle whitening and preparation method thereof |
| CN107510619B (en) * | 2017-09-06 | 2020-11-24 | 深圳肽之妃科技有限公司 | Composite polypeptide mask and preparation method thereof |
| CN107854326A (en) * | 2017-12-19 | 2018-03-30 | 乳山寰海生物科技有限公司 | A kind of hirudin moistens face moisturizing maintenance Essence |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN103006511A (en) * | 2012-12-21 | 2013-04-03 | 山东侨牌集团有限公司 | Hirudin skin-whitening moisture-keeping conditioning cream and production process thereof |
| CN105125474A (en) * | 2015-09-22 | 2015-12-09 | 夏放军 | Essential toner and preparation method thereof |
| CN105147559A (en) * | 2015-09-25 | 2015-12-16 | 夏放军 | Skin cream and preparing method thereof |
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Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103006511A (en) * | 2012-12-21 | 2013-04-03 | 山东侨牌集团有限公司 | Hirudin skin-whitening moisture-keeping conditioning cream and production process thereof |
| CN105125474A (en) * | 2015-09-22 | 2015-12-09 | 夏放军 | Essential toner and preparation method thereof |
| CN105147559A (en) * | 2015-09-25 | 2015-12-16 | 夏放军 | Skin cream and preparing method thereof |
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