JP2002241293A - Maillard reaction inhibitor - Google Patents

Abstract

PROBLEM TO BE SOLVED: To provide a new and safe Maillard reaction inhibitor, cosmetic composition or food/beverage. SOLUTION: This Maillard reaction inhibitor, cosmetic composition or food/ beverage includes at least one kind of extract from plant (s) selected from Akebia, Aloe, Prunusarmeniaca Linne var. anzu Maximowicz, Piper methysticum Forst., Platycodon, Kadsura, Panax sanchi Hoo, Bidens tripartita L., Polygonatum falcatum A. Gray, stellaria, Tetragonia, Ponia cocos(Fr.) Wolf and Citrus junos Tanaka. The above cosmetic composition or food/beverage can be utilized as the Maillard reaction inhibitor, affords the skin with firmness, is effective for preventing/ameliorating dry skin, can be utilized in preventing and treating diseases associated with various Maillard reaction inhibitions including skin resilience decline such as skin wrinkles and flabbiness, skin aging and diabetes-derived complications, and also is highly safe even if used internally or externally.

Description

DETAILED DESCRIPTION OF THE INVENTION

[0001]

[0001] The present invention relates to a novel and safe Maillard reaction inhibitor containing a plant extract, and further to its application to cosmetic compositions or foods and beverages.

[0002] The field of application is, for example, all kinds of internal and external preparations (including preparations for animals), and specifically, ampules, capsules, pills, tablets, powders, granules , Solids, liquids, gels or foams 1) pharmaceuticals, 2) quasi-drugs, 3) topical or systemic skin cosmetics (eg, lotions, emulsions, creams, ointments, lotions, oils, packs) And other basic cosmetics, facial cleansers and skin cleansers, massage agents, cleansing agents, depilatory, depilatory, shaving treatments, aftershave lotion, pre-show lotion, shaving cream, foundation, lipstick, blusher, eye Make-up cosmetics such as shadows, eyeliners, and mascaras, perfumes, nail polish, nail enamel, nail enamel removers, cataplasms, plasters, tapes, Preparations, patches, aerosols, etc.), 4) medicinal or / and cosmetic preparations applied to the scalp / hair (eg, shampoos, rinses, treatments, permanent liquids, hair dyes, hair dressings, Hair tonics, hair growth / hair restoration, poultices, plasters, tapes, sheets, patches, aerosols, etc.), 5) bath agents to be poured into bath water, 6) other axillary deodorants and deodorants Deodorants, deodorants, sanitary articles, sanitary cotton, wet tissues, mouth fresheners (eg, toothpaste, mouthwash) and the like.

[0003] Foods and drinks further include oral compositions (gum, candy, etc.), processed seafood products such as kamaboko and chikuwa, livestock products such as sausage and ham, western confectionery, Japanese confectionery, raw noodles, Chinese noodles, and yudemen. Noodles such as buckwheat, sauce, soy sauce, sauce, sugar, honey, powdered candy,
Seasoning such as syrup, curry powder, mustard powder, spices such as pepper powder, jam, marmalade, chocolate spread, pickles, soy sauce, sprinkle, or processed vegetables and fruits such as canned and bottled vegetables and fruits, Dairy products such as cheese, butter, yogurt, miso soup, soup, fruit juice,
It can be used for beverages such as vegetable juices, whey drinks, soft drinks, alcoholic beverages, and other general foods and drinks such as health foods.

[0004]

2. Description of the Related Art It is natural that all people age with aging. However, in recent years, aging has been caused by deterioration of environmental conditions, changes in lifestyles, and increased stress accompanying the complication of social life. The factors that are promoted are increasing. In particular, the importance of living healthy every day has been reconsidered with the increase in the number of elderly people and the prolongation of their lives, and the suppression of the progress of aging has been awaited by everyone.

[0005] Aging refers to the deterioration of various functions of the body. When this is considered at the cellular level, various physiological functions in a living body are controlled by proteins. In other words, aging is considered to be a state in which the protein cannot exert its original function due to some kind of disorder given to this protein, and one of the disorders is non-enzymatic protein saccharification reaction. . This is a reaction in which the intrinsic function of the protein is impaired by the binding of the reducing sugar and the amino acid or protein, and is called a Maillard reaction (browning reaction). still,
The initial stage reactant of the Maillard reaction is a protein-sugar conjugate called an Amadori compound, and this reaction forms a yellow-green substance having fluorescence through dehydration and polymerization. Become.

[0006] It is presumed that the dysfunction due to protein saccharification causes complications due to diabetes or senile dementia.

[0007] In addition, wrinkles and sagging of the skin of a person who comes into contact with the outside world are seen with aging, and the gloss and tension of the skin decrease. This is because changes in the dermis constituents have a large effect, and collagen (collagenous fibrils) and elastin (elastic fibers) crosslink due to glycation of proteins by the Maillard reaction. In particular, crosslinks between collagen fibers due to protein saccharification are initially required to increase mechanical strength, but gradually increase unnecessary crosslinks, causing a decrease in skin elasticity, causing wrinkles and sagging. It has been.

[0008] Saccharification of proteins that progresses in vivo, which is aging at the cellular level, has attracted attention as a cause of skin aging, diabetic complications, and various cell disorders. However, only a handful of drugs that inhibit the Maillard reaction, such as aminoguanidine, are known, and at present the effect of inhibiting the Maillard reaction is not very strong.

[0009]

In view of such circumstances, the present inventors have shown that the present invention has an excellent Maillard reaction inhibitory effect by using the amount of pentosidine, one of the final products of the Maillard reaction, as an index. For substances with no side effects, we have tried to screen natural plants, and have been studying new plant extracts.

[0010]

Therefore, the present inventors have developed a plant extract from akebi, aloe, apricot, hippo, kikyo, goji, sanshin ginseng, taukogi, narko lily, chickweed, pentosidine from plant extracts from hamazsha, bukurou and yuzu. Confirm that it has a production inhibitory effect, and apply it as a Maillard reaction inhibitor. In addition, to give the skin a luster and firmness, to improve dry skin, and to prevent or improve the deterioration of skin elasticity such as wrinkles and sagging of the skin. And, by providing a safe cosmetic composition or food and drink,
The present invention has been completed.

[0011]

DESCRIPTION OF THE PREFERRED EMBODIMENTS "Akebi" used in the present invention
Akebiaceae (Lardizabalaceae), Akebia (Akebia)
Plant: Akebia "Akebia quinata (Houtt.) Decne." Flower,
A spike, a pericarp, a fruit, a stem, a leaf, a branch, a branch, a leaf, a stem, a bark, a rhizome, a root bark, a root, a seed, or a whole plant is used. And A. pentaphylla Makino can also be used.

"Aloe" used in the present invention is a lily family
(Liliaceae), a plant of the genus Aloe: Aloe vera "Aloe"
barbadensis Mill. (= A.Vera L.) "and its variant" A.Vera
L.var.chinensis (Haw.) Berger '', A. saponaria Haw. Flower, spike, pericarp, fruit, stem, leaf, branch, foliage, stem, bark,
Rhizomes, root bark, roots, seeds or whole plants are used, but in addition, congener species of Kidachi aloe (A. arborescens Mill.), Socotra aloe (A. perryi Baker), Natal aloe (A. bainesii)
Th.Dyer), Aloe dicotoma (A. dichotohoma L.), Aloe marlothii (A. marlothii Berger), Aloe pestris (A. rupestris Baker), Aloe spinoshima (A. spine)
osissima Hort.), Aloe plicatilis (A. plicatilis)
Mill.), Aroasperifolia A.Be
rger), Aloe Capitata Polypolinicola (A. captata Ba
k.var.cipolinicola H.Perr.), Aloe Sprendence
(A. splendens Lavranos), Aloe Fumiris (A. humilis M
ill.), Aloe Mitriformis Mil (A. mitriformis Mil
l.), Aloe Weliegata (A.variegata L.), Cape Aloe (A.ferox Mill.), Aloe Africana (A.africa
naMill.), Aloe spicata (A.spicata Baker), A.haw
orthiodes Baker, A. succotrina Lam., etc., and variants thereof can also be used.

The term "apricot" used in the present invention refers to a roseaceae.
(Rosaceae), plant of the genus Prunus: Prunus
armeniaca Linne var.anzu Maximowicz) flowers, spikes,
Peel, fruit, stem, leaf, branch, foliage, stem, bark, rhizome, root bark, root, seed or whole plant is used. americana Marsh.), P. avium
L.), P. cerasus L., Peach peach
(P.domestica Lindl.), Plum (P.salicina Lindley),
Santo (P.persica Batsch var.davidiana Maximowic
z), common peach (P.persica Batsch var.persica), nectarine (P.persica Sieb.et Zucc.var.nucipersica Sc
hneid.) can also be used.

The term "hippopotamus" used in the present invention refers to the plants of the family Pepperaceae and the genus Pepper: flowers, spikes of hippopotamus (aka kava) (Piper methysticum Forst.).
Peel, fruit, stem, leaf, branch, foliage, stem, bark, rhizome, root bark, root, seed or whole plant is used, but besides, betel (P. betle L.) and Cubeba (P. cubeba) Lf), Bush Pepper (P.guineense Schum.et Thonn.), Houtou Kazura `` P.kadsura (Choisy) Ohwi '', Indian Nagako Pepper (P.
longum L.), pepper (P.nigrum L.), (P.peltata
L.), P. retrofractum Vahl and the like can also be used.

The term "kikyo" used in the present invention means a plant of the family Capelinaceae (Campanulaceae), or a plant of the genus Psychodon (Platycodon):
A spike, a pericarp, a fruit, a stem, a leaf, a branch, a branch, a leaf, a stem, a bark, a rhizome, a root bark, a root, a seed, or a whole plant is used.

The term "gomushi" used in the present invention means a plant belonging to the family Scorpionaceae (Schizandraceae) or the genus Kadsura (Kadsura): "Kadsura japonic"
a Dunal. (= K.longipendunculata Finet.et Gagnepen),
(= K.peltigera Rehd.) "
e), plant of the genus Schizandra: Datura
(Schizandra chinensis Baill.), Matsubusa `` S.repanda
(Sieb.et Zucc.) Radlk. (= S.nigra Maxim.) '', S.sphenan
thera Rehd.et Wils. flowers, spikes, pericarp, fruits, stems,
Leaves, branches, foliage, stems, bark, rhizomes, root bark, roots, seeds or whole plants are used, but other homologous species can also be used.

The term "sansin ginseng" used in the present invention means "Araliaceae" and "Panax".
Plants: Panax ginseng (also known as Density ginseng) "P
anaxnotoginseng (Burk.) FHChen (= P.sanchi Hoo) "
Use rhizomes, root bark, roots, seeds or whole plants, but also use P. pseudo-ginseng Wall.var.notoginseng (Bur
k.) Hoo et Tseng ", Panax ginseng (also known as Ginseng ginseng) (P. japonicus CAMey), American ginseng (Pq
uinquefolium L.), Panax ginseng (P. ginseng CAMey
er), P. pseudo-ginseng Wall., P. bipinnatifidus See
m., P. major (Burk.) Ting, etc. can also be used.

"Taukogi" as used in the present invention is a plant of the family Asteraceae (Compositae), genus Bidens (Bidens): flowers, spikes, pericarp, fruits, flowers of turkey (Bidens tripartita L.).
Use stems, leaves, branches, branches and leaves, stems, bark, rhizomes, root bark, roots, seeds or whole plants, but other species of the same genus
(Also known as American Sendangusa) (B. frondosa L.), Sendangusa "B. biternatus (Lour.) Merr. Et Sherff", B. parviflora Willd., And the like can also be used.

The "narco lily" used in the present invention is a plant of the genus Liliaceae or Polygonatum:
Narco Lily (also known as Nosuzuran) (Polygonatum falcatum
A.Gray) flowers, spikes, peels, fruits, stems, leaves, branches, foliage,
Use stem, bark, rhizome, root bark, root, seeds or whole plant,
In addition, the congener species of the key
Delar.ex Rodoute), P.cyrtonema Hua, P.cirrhifoliu
m (Wall.) Royle, P.kingianum Coll.et Hemsl., P.lasianthum Maxim., P.macropodium Tur
cz., P. verticillatum (L.) All., P. roseum (Ledeb.) Kunt
h, P.filipes Merr., P.curvistyum Hud., P.stenophyllum Maxim., P.zanlanscianense P
amp., P. nodosum Hua, P. alternicirrhosum Hand.-Maz
z., P.punctatum Royle ex Kunth, P.hirtellum Hand.-
Mazz., P.cirrhifoliodes DMLiu et WZZeng, P.str
umulosum DMLiu et WZZeng, Amadokoro (P. odoratu
m Druce var. pluriflorum Ohwi) can also be used.

[0020] The term "Hawkweed" used in the present invention is a plant belonging to the family Caryophyllaceae or Stellaria.
Hakobe (alias: Kohakobe, Hakobella, Assassinage) "Stell
ariamedia (L.) Villars '' flowers, spikes, pericarp, fruits, stems,
Use leaves, branches, foliage, stems, bark, rhizomes, root bark, roots, seeds or whole plants, but also other species of the same species, S. negle
cta Weihe), Gin Psycho (S.dichotoma L.var.lanceolat)
a Bge.), `` S.aquatica (L.)
aquaticum (L.) Fries) "and the like.

As used herein, "Hamajisha" refers to a plant belonging to the family Azioaceae and the genus Tetragonia: "Tetragonia tetragonoides (Pall.) O. Kuntze (= T.
expansa Murr.), (= Desmovia tetragonoides Pall.) '' flowers, spikes, pericarp, fruits, stems, leaves, branches, foliage, stems, bark,
Species using rhizome, root bark, root, seed or whole plant can be used, but other congeners can also be used.

The term "bukuro" used in the present invention refers to plants of the genus Polyporaceae (Polyporaceae) and the genus Anato (Poria):
olf (= Pachyma hoelen Rumph, Pachyma cocos Fr.)
A reproductive branch, a spermatogenesis device, or an ovipositor, which is a temporary root or a breeding body, can be used, but other congeneric species can also be used.

"Yuzu" used in the present invention is Rutaceae (R
utaceae), a plant of the genus Citrus: Yuzu "Citrus ju
nos Tanaka (= Citrus junos Sieb.ex Miq.) ”, flower, spike, pericarp, fruit, stem, leaf, branch, foliage, stem, bark, rhizome,
Root bark, roots, seeds or whole plants can be used, but other species such as Hanayu (C. hanaju Hort. Ex Shirai) of the same genus or metaphobic citrus subgenus, Yuzu ward, Shinyuzu sub ward can also be used.

It should be noted that the extracts of akebi, aloe, apricot, hippo, kikyo, goshi, carrot, ginseng, panax, narco lily, lycopodium, hakobe, hamakusha, bakuryo and yuzu used in the present invention include various parts of each plant. (flower,
Spike, pericarp, fruit, stem, leaf, branch, foliage, stem, bark, rhizome, root bark, root, seed or whole plant, fruiting body, sclerotium, mycelium,
Temporary roots, reproductive branches, spermatozoa, egg ovum, etc.) as they are or after crushing and exploited. Alternatively, it is extracted with a solvent as it is or after pulverization.

The extraction solvent for the above various plant extracts includes water, alcohols (for example, lower alcohols such as methanol, anhydrous ethanol and ethanol, and propylene glycol, 1,3-butylene glycol and glycerin). (Hydric alcohol), ketones such as acetone, esters such as ethyl ether, dioxane, acetonitrile, and ethyl acetate, and organic solvents such as xylene, benzene, and chloroform may be used alone or in any combination of two or more. It can also be used in a state where each solvent extract is combined.

The production method is not particularly limited, but may be usually within the range of the boiling point of the solvent at normal temperature and normal pressure.
A solution, paste, gel, or powder may be obtained by decoloring / purifying. In many cases, it can be used as it is, but if necessary, further purification treatment such as deodorization and decolorization may be added as long as the effect is not affected. An activated carbon column or the like may be used, and ordinary means generally applied to the extracted substance may be arbitrarily selected.

In addition, various plant extracts such as akebi, aloe, apricot, hippo, hippo, beetle, ginseng, panax ginseng, turmeric, narco lily, chickweed, hamazsha, bukuroyou and yuzu are used as Maillard reaction inhibitors and cosmetic compositions. Alternatively, drying, concentration or dilution may be arbitrarily performed and adjusted depending on the dosage form and form of the food or drink.

The akebi, aloe, apricot, hippo,
Various plant extracts of Kikyo, Gomushi, Panax ginseng, Taukogi, Narco lily, Hakobe, Hamazusha, Bukuryo, Yuzu can be used as a Maillard reaction inhibitor as they are, and can be further contained in a cosmetic composition or food or drink. Although not particularly specified as the content,
Depending on the type, quality and expected degree of action of the Maillard reaction inhibitor, cosmetic composition or food or drink, it is usually 0.001% by weight in terms of solid content in the total amount of the preparation.
Above (hereinafter expressed in%), preferably 0.1 to 50.0%. If the content is less than 0.001%, the effect cannot be expected sufficiently. In the case of a bath agent, the formulation may be considered so as to be poured into 200 to 300 L of bath water so as to have a similar concentration.

The Maillard reaction inhibitor, the cosmetic composition or the food or drink of the present invention may further contain, if necessary, the components and additives described below as long as the effects of the present invention are not impaired. It can be manufactured by optionally selecting and using the agent, the content in the formulation is not particularly specified, but usually,
0.0001 to 50% is preferred.

(1) Various fats and oils Avocado oil, almond oil, fennel oil, perilla oil,
Olive oil, orange oil, orange luffer oil, sesame oil, cocoa butter, chamomile oil, carrot oil, cucumber oil, tallow fatty acid, kukui nut oil, safflower oil, shea butter, liquid shea butter, soybean oil, camellia oil, corn oil, rapeseed Oil, persic oil, castor oil, cottonseed oil, peanut oil, turtle oil, mink oil, egg yolk oil, palm oil, palm kernel oil, mocro, coconut oil, tallow, lard, or hydrogenated products of these oils (hardened oil, etc.) )etc.

(2) Waxes Beeswax, carnauba wax, whale wax, lanolin, liquid lanolin, reduced lanolin, hard lanolin, candelilla wax,
Montan wax, shellac wax, rice wax, squalene, squalane, pristane, etc.

(3) Mineral oil Liquid paraffin, vaseline, paraffin, ozokelide, ceresin, microcrystalline wax and the like.

(4) Fatty acids Natural fatty acids such as lauric acid, myristic acid, palmitic acid, stearic acid, behenic acid, oleic acid, 12-hydroxystearic acid, undecylenic acid, tall oil, lanolin fatty acid, isononanoic acid, caproic acid And synthetic fatty acids such as 2-ethylbutanoic acid, isopentanoic acid, 2-methylpentanoic acid, 2-ethylhexanoic acid and isopentanoic acid.

(5) alcohols ethanol, isopiranol, lauryl alcohol,
Natural alcohols such as cetanol, stearyl alcohol, oleyl alcohol, lanolin alcohol, cholesterol, phytosterol, phenoxyethanol,
2-hexyldecanol, isostearyl alcohol, 2-
Synthetic alcohols such as octyldodecanol.

(6) Polyhydric alcohols Ethylene oxide, ethylene glycol, diethylene glycol, triethylene glycol, ethylene glycol monoethyl ether, ethylene glycol monobutyl ether, diethylene glycol monomethyl ether, diethylene glycol monoethyl ether, polyethylene glycol, propylene oxide, propylene glycol , Polypropylene glycol, 1,3-butylene glycol, glycerin, pentaerythritol, sorbitol, mannitol and the like.

(7) Esters: Isopropyl myristate, isopropyl palmitate, butyl stearate, hexyl laurate, myristyl myristate, oleyl oleate, decyl oleate, octyl dodecyl myristate, hexyl decyl dimethyloctanoate, cetyl lactate, Myristyl lactate, diethyl phthalate, dibutyl phthalate, lanolin acetate, ethylene glycol monostearate, propylene glycol monostearate, propylene glycol dioleate and the like.

(8) Metal soaps Aluminum stearate, magnesium stearate, zinc stearate, calcium stearate, zinc palmitate, magnesium myristate, zinc laurate, zinc undecylenate and the like.

(9) Gum, sugar or water-soluble polymer compound Arabic gum, benzoin gum, dammar gum, guaiac oil, Irish moss, karaya gum, tragacanth gum,
Carob gum, quinseed, agar, casein, lactose,
Fructose, sucrose or an ester thereof, trehalose or a derivative thereof, dextrin, gelatin, pectin, starch, carrageenan, carboxymethyl chitin or chitosan, hydroxyalkyl (C2-C4) to which an alkylene (C2-C4) oxide such as ethylene oxide is added. )
Chitin or chitosan, low molecular weight chitin or chitosan, chitosan salt, sulfated chitin or chitosan, phosphorylated chitin or chitosan, alginic acid or its salt, hyaluronic acid or its salt, chondroitin sulfate or its salt, heparin, ethyl cellulose, methyl cellulose, carboxymethyl cellulose , Carboxyethyl cellulose, sodium carboxyethyl cellulose, hydroxyethyl cellulose, hydroxypropyl cellulose, nitrocellulose, crystalline cellulose, polyvinyl alcohol, polyvinyl methyl ether, polyvinyl pyrrolidone, polyvinyl methacrylate, polyacrylate, polyalkylene oxide such as polyethylene oxide and polypropylene oxide Or its crosslinked polymer, carboxyvinyl polymer, polyethylene N'imin like.

(10) Surfactant Anionic surfactant (alkyl carboxylate, alkyl sulfonate, alkyl sulfate, alkyl phosphate), cationic surfactant (alkyl amine salt, alkyl quaternary ammonium salt) ), Amphoteric surfactant:
Carboxylic acid type amphoteric surfactant (amino type, betaine type), sulfate ester type amphoteric surfactant, sulfonic acid type amphoteric surfactant, phosphate ester type amphoteric surfactant, nonionic surfactant (ether type nonionic Surfactants, ether ester type nonionic surfactants, ester type nonionic surfactants, block polymer type nonionic surfactants, nitrogen-containing nonionic surfactants), other surfactants (natural surfactants) , Derivatives of protein hydrolysates,
Polymer surfactants, surfactants containing titanium and silicon,
Fluorocarbon surfactants).

(11) Various vitamins Vitamin A group: retinol, retinal (vitamin A
1), dehydroretinal (vitamin A2), carotene, lycopene (provitamin A), vitamin B group: thiamine hydrochloride, thiamine sulfate (vitamin B1), riboflavin (vitamin B2), pyridoxine (vitamin B)
6), cyanocobalamin (vitamin B12), folic acids,
Nicotinic acids, pantothenic acids, biotins, choline,
Inositols, vitamin C group: vitamin C acid or its derivative, vitamin D group: ergocalciferol (vitamin D2), cholecalciferol (vitamin D3),
Dihydrotaxelol, vitamin E group: vitamin E or its derivatives, ubiquinones, vitamin K group: phytonadione (vitamin K1), menaquinone (vitamin K
2), menadione (vitamin K3), menadiol (vitamin K4), other essential fatty acids (vitamin F), carnitine, ferulic acid, γ-oryzanol, orotic acid, vitamin Ps (rutin, eriocitrin, hesperidin), vitamin U etc.

(12) Various amino acids Valine, leucine, isoleucine, threonine, methionine, phenylalanine, tryptophan, lysine, glycine, alanine, asparagine, glutamine, serine, cysteine, cystine, tyrosine, proline, hydroxyproline, aspartic acid, glutamic acid , Hydroxylysine, arginine, ornithine, histidine, etc., and their sulfates, phosphates, nitrates, citrates,
Or amino acid derivatives such as pyrrolidone carboxylic acid.

(13) Various additives derived from plant or animal raw materials These are usually processed according to the type and form of the product to be added (for example, pulverization, milling, washing, hydrolysis, Fermentation, purification, squeezing, extraction, fractionation, filtration, drying, powdering, granulation, dissolution, sterilization, pH adjustment, deodorization, decolorization, etc. You can choose to serve.

The solvent to be used for the extraction may be selected in consideration of the purpose and type of the product to be provided, or the processing to be performed later, but usually, water, methanol, ethanol, propyl alcohol, isopropyl alcohol, etc. Select from alcohols, lower alcohols such as butanol, isobutanol or water-containing lower alcohols, polyhydric alcohols such as propylene glycol, 1,3-butylene glycol, glycerin or water-containing polyhydric alcohols, acetone and various organic solvents such as ethyl acetate. It is desirable to use one or a mixture of two or more of these. However, when the content of the organic solvent is not preferable depending on the application, only water may be used, or ethanol which is easily removed after extraction may be used, and may be used alone or in an arbitrary mixed solution with water. Exploited extract may be used.

In addition, additives derived from plant or animal raw materials are
When applied to systemic or topical external preparations and cosmetics, including protection of skin and hair, moisturizing, improvement of feel and texture,
Gives flexibility, relieves irritation, relieves stress by fragrance, activates cells (prevents cell aging), suppresses inflammation, improves skin and hair quality, prevents and improves rough skin, hair growth, hair growth, hair loss prevention, gloss Application, cleaning effect, relief of fatigue, promotion of blood flow,
In addition to cosmetic effects such as warm bath effect, fragrance, deodorant, thickening,
Antiseptic and buffering effects can also be expected.

In foods and drinks, there are healthy and cosmetic effects such as nutritional supplementation, recovery from fatigue, tonicity, cell activation (prevention of cell aging), improvement of taste, provision of color tone, aroma and gloss, stabilization, It can be used for the purpose of thickening, preserving, etc. Furthermore, in addition to this, we expect various cosmetic and pharmacological effects of each raw material known so far, and aim to increase the intended effect by combining them,
Alternatively, it is possible to provide a product that is expected to have a multifunctional effect.

As a specific plant (crude) used as a raw material,
For example, almonds (Hentomo), eye (Aiba), Blue Kazura
(Seifu Fuji), Aoki (Aoki), Aokiri or Kenasia Ogiri
(Otogi), Aotsu-la-fuji (Kibo), Aotenma, Acacia, Akasho (Akasho), Akasuguri (fruit), Red clover, Red grape, Akaminoki (Logwood), Akamegawiwa (Red bud), Akaminokane or Akane Akane or Akane (Akane) Grass root), red pheasant or pheasant (land yellow),
Agui (Awei), Aki larch, Akinire (Lolyu bark), Aguay Guacu, Aguahe (Wolverine palm), Asa
(Asako Jin), Malva Asagao or Asagao (Toshiboshi), Hydrangea (Hydrangea), Ashitaba (Asuka), Azuki (Red Azuki), Asunaro, Acerola, Asenyak (Asenyaku), Achilla (Shokuyokanna), Anise, Abiu , Abiulana, rape, abemaki "fruit", avocado, ama, amacha
(Amacha), Amachaul, Amana (Kojingi), Amaranthus
(Amaranthus, Balsam pear, Hymenoptera, Senninkoku, Sugimorigeito, Hosoaoigaito, Aogaito, Haribiyu, Aosuzuran, Amaranthus hippochondriax), Amigasa lily or Bimo (shellfish), Aristolomelia (Yurizuisen), Arcana (Alcana), Algana , Altea, Arnica, Alpinia or Katsumadai (Sou-zuku), Angelica, Ansokkou
(Benzoic acid), yellow sapote, Ikakouzolina (bile head),
Epimedium or Periwinkle (Indian kaku), Igusa (light heart grass), Knotweed (Tiger root), Yew (No. 1), Strawberry, Fig (Figurine `` fruit, leaf ''), Ichihatsu (Initial),
Ichibi (Aoiko Fuyu), Ichiyakusou (one medicinal herb), Ginkgo (Ginkgo `` seed, leaf ''), Itohimehagi (Enshi), carob,
Inazuna (Teirexi), Inubeil (Honaguinubiru),
Rice `` seed, seed coat '', Inondo `` seed '', Ibuki-kusou-so, nettle, ylang-ylang, iwa-tobacco (iwatsuchi-chi), iwahiba or iwamatsu (makikashiwa), oolong tea, wikyo (fenka), wheat (tibusanoki), ukiyagara (miyoko) ), Uguisukagura `` fruit '', Himeuikyo, Turmeric (Utsukin), Duckweed (Floating), Usubasaishin or Keirinsaishin or Oushusaishin (spicy), Usvenia oyster, Usbeni tachioi, Uchoura, Utsubogusa
(Summer hay), Udo or Shishiudo (Qanggai, Independent, Tang Dungho), Unyadegato (Unkaria, Cat's claw), Uba tea, Ume (Omeme `` seed, flesh ''), Vladimir, Uwaurushi
(Kusaco peach), Unshu mandarin orange (Chen skin), Unboku,
Estragon, Ezokogi (Ezo Goka), Ezo lily of the valley,
Echinashi (Hoshibamurasakibarengiku), Enishida, Enokitake (Enotake), Ebisugusa or Cassia Tora (Keyoshiko), Elcampre, Elderberry `` fruit '', Elemi, Elingii or Pre Lotus Elinge, Ende
(Gossip flower, Sophora rice), ogi or Kibana-ohgi (Astragalus), Ohisasanoyuki or Sasanoyuki, Ouren (Yellow), Ogata Hawken, Okarasuuri (Karokon), Oogurama
(Civil engineering incense), Otsu-la-fuji (self-defense), Psyllium (Komazenko,
Foreground grass), Thistle (Keju Leak, Hakuko), Toucan (Haruko), Toucan cactus, Owana okera or Okera (white jitsu), Obanasarusuberi (banaba), Obanayasabushi (fruit), Oohoshigusa (cereal grass), Oumia Katetsu, Omi Hawthorn or Hawthorn (Yamako), Barley (barley), Oka, Okazeri (Snake bed), Okra `` Fruit '', Oguruma (Wrapping), Oculli Higotai (Yusyu Roshi,
Indigo head), St. John's wort or Scutellaria perforatum or St. John's wort (brother's cut), St. John's wort (intermittent),
Onami fir (blue ears), onigurumi, onidokoro or tokoro or nagadokoro (hikai), oninoyagara (Tianma), oniyuri or sasasayuri or hakatayuri (yuri), onoeran, ononis, halibut (hihayu), ominaeshi (soy sauce), oyuko , Dutch mustard (Watercress), Dutch jelly, Dutch biyu, Dutch honeybee, olive "fruit, seed,
Leaf '', oregano, orange `` fruit, pericarp '', caycaio (ripe yellow), cacao `` fruit, pericarp, seed '', persimmon (persimmon `` leaf ''), kagikazura (fishing hook), persimmon or perilla (loten) Grass), kakiran, gaku hydrangea, cassia,
Kasinaki (Kozomi `` fruits ''), gajutsu (shajutsu), Kashiwa (Kazuki, Kayoha), Kasukaira, Kaskarasagrada, Kasumiso, Kasensou, Kanixa (Kanasato), Kaniwa, Carnation, Kanokosou (Yoshikone), Birch Or weeping birch (birch), gerbera, pumpkin, capoknoki `` seed '', kahoku sansho (shopper), cattail (bamboo), chamomile or roman chamomile, chamomile (weed), camu cam (camouflage), color, karaoke salmon man, crow squirrel or china Calla squirrel (flower meadow), crow squirrel (midsummer), oats wheat, guarana `` seed '', karahoo (thick), karaya, garyu, karin (gourd), garcinia, kawamidori, kawara psycho (kelinsai, translucent grass), kawajisha , Kawatake mushroom, Kawaranadeshiko (stone bamboo) or Ezokawaranadeshiko (Qumugi, Quumiko), Kawamuragi (Inchinchinko), Kansu (Ama遂), licorice (licorice), Kantaraasa, candelilla, Kanto, canna, olivine, raspberry (Ezoichigo, Netherlands strawberries, wine raspberry, native raspberry, Momijiichigo,
(European strawberry), Kiwi `` fruit, leaf '', Kikarasuuri (Ururone), Chrysanthemum (Chrysanthemum, Shimakangiku, Datura), Kikutaniku, Catalpa (Azusa), Ripepeaceus (Yotei), Pheasant (Kimitsu), Kizuta, Mint, kina,
Linden (shincona, red linden), quinoa (quinoa), yellowfin (huangkashii), gymnema sylvestre, kimmenkaku, cabbage, cabbage `` immature fruit '', caraway, cucumber, gyoryu (Nishikawayanagi, teruyanagi), Kiraja saponaria, Kiraya , Giraffe (golden acne), kumquat `` fruit '', ginseng, kimbusen, kinmizuki (senkaku grass), quinran, ginran, kinryohen, guapeba vermelha, guava `` fruit '', guayule, quelux infectria (gallicia), kukuinuts,
Kugenumaran, wolfberry (Mushroom, Mushroom, Mushroom leaf, ground bone),
Kusugi Kazura (Tenmen Winter), Kudzu (Kakkon), Camphor Tree, Gooseberry `` Fruit '', Cutiti River, Gardenia (Gardenia), Kunugi (Bokusou), Kupuas, Kumazasa, Kumatsuzura (Mawhispera), Clara Cranberry `` fruit '', chestnut `` seed, fruit, astringent skin '', curcrigo latifolia `` fruit '', grapefruit `` fruit / leaf '', buckthorn, black crocodile mochi (rescue rescue), turtle bamboo sprouts or black blossom sprouts or cypress (extended life grass), cloves
(Cinch, cinch), Gumbai nazuna (Sekimei, Sekimeishi), Kaigai (Ikutake, Ikutakeho), Keito (Rooster corolla, Chicken cop), Gekkavidin, Geckage (laurel), Kenashi Sartoriibara (Tokubukuryo, Yamakiko), Gentian, Gennoshoko (Old Tokusa), Kemponashi (Kigushi), Koukisekikoku, Kishumitsukan (Koji, Tachibana, Obenimikan, Fukuromikan, Sagamikouji, Ponkan, Santara
(Tachibana skin)), Koshinbara (Monthly flower), Kosui mint, Kozo `` fruit '', Kocha (tea), Kouhone (river bone), Kouhon (straw, Kara straw), Koulyan, Kouryokyo
(Kora Kyo), Cilantro `` fruit '', Kouen (Huanglian),
Koganebana (Yellow Gon), Cowberry (Koshibachi), Coco Palm (Fruit), Goshuyu (Gusyuyu), Goshoi Strawberry (Ubonishi), Cosmos, Copaiba Balsam, Coffee `` Seeds, Leaves '', Kobushi or Magnolia (Spice), Burdock ( Burdock, burdock), coconut wool, sesame (sesame), sesame seeds (ginseng), wheat (wheat), rice or rice bran “red bran, white bran”, rice oil, cola acuminata “seed”, cola vera “seed” , Colony lyre, fenugreek `` fruit '', colombo, kondulango, kelp, konjac, comfrey (finnari grass), sisal (sisalasa), saihailan, sakanelan (ezosakaneran), saxima button or cinnamon button or cinnamon pine (Ooshimazakura, Yamazakura, Oyamazakura, Edhigashi, Mamezakura, Miyamazakura, Yoshino cherry tree, Takanezaku , Prunus Subhirtella,
Satozakura, Kanzakura `` leaves, flowers, fruits, bark (cherry bark) ''), cherries, pomegranate, sasa, sasabaginran,
Sasanqua, Sajiomodaka (Sawaka), Sweet potato, Sugar cane, Sugar beet, Sanebu jujube (Saccharin jujube), Saffron (Bamboo safflower, West safflower), Sapodilla, Sapotea marillo, Pomelo `` fruit '', Sabonsou, Salmon berry `` Fruit '', Sarasin Hemp), salanchito (sand sashimi), salvia (sage), sawagyoukyo (yamachona), sawagurumi (yamawalnut), sankaku cactus, sangre de grad (croton), sanshiyouyouso, sanshuyu (sanshuyu), sanshayu (sanshuyu) Sansho), Sandscon (Yamazone), Shea (Carite), Cyano (Fruit), Shiitake (Shitake), Shion (Shion), Dikitaris, Shikunshi (Kimiko), Perilla or Aodiso or Chirimendiso or Katamenziso (Shiyo leaf, Shiso) Offspring), rosewood, linden, Chinese pine, Chinese forsythia,
(Hinshimeji, Shakashimeji, Hatakeshimeji, Oshiroishimeji, Bunashimeji, Honjimeshi, Shirotamogitake),
Shimokure (Spirit), Spiraea, Potato, Peony (Shakuyaku), Shajin (Shasan), Jasmine (Matsurika), Janohige (Motomon winter), Scutellaria paniculata, Skushamitsu (sand sand, shrinking sand), Juzudama, Shiro Fruits, Shunlan, Ginger (Ginger), Jouzan Hydrangea (Tsuneyama), Shobu (Iris, Iris root), Shozuku (Fruits), Shirakashi (Seeds), Silane (Byanchu), Shirogoshi Butterflies (Seeds), White clover (Clover), White adzuki bean (chicken bone grass), white bean iris (small iris), white bean ivy `` flower '', white nananthen (minamitenmi), cinchona sassilbra, ginkgo biloba (mizuka, mizukahana, kenchohana),
Cinnamon, Cinnammom Cassia (Cinnamon Bark), Watermelon
(Watermelon), honeysuckle (gold and silver flowers, Shinobi winter), sorrel (acid pattern), swimberry `` fruit '', star apple, stevia, strawberry `` fruit '', tin psycho (Xucho Lord), sugina (question thorn), suberhide (horse ken, Kenko Horse Tooth), Surgaran
(Oran), Pinus densiflora `` cone '', Larix sylvestris, L. pear L., L. prunus radiata, L. var. Albino
(Juniper, Juniper), Yarrow (milfoil), Rose of the valley, European cornflower, European mistletoe, Western mint or Western mint, Western horseradish, Japanese horseradish, Sekisho (Iris)
(Sakurasecekku, Kokkisecekku, Obananasecekku, Okinawawasecekku, Honsecekku, Kochosecekku, Shikakusecekku, Kibananosecekku) (Dendrobium, Ishimasu), Cedron (Boshishuboku), Zeniaoi,
Hirohase Nega, Senega, Seri, Celery, Senkyu (River Kyu), Senshinren (Senshinren), Sendan, Sennin Cactus, Senna "Fruits, Leaves", Senninsou (Otate Tate),
Assemblage (drug), senboku, souka (grass), elephant ginger, soshinrowai, buckwheat "seed", radish, daikon (radish), radish, soybean, daidai (orange peel, kikomi), takasago rurihigatai (southeast indigo sashimi) ), Takasaburo (Dried lotus grass), Takatodai (Daigo), Takawarabi (Inu spine), Dark sweet cherry `` Fruits '', Tachiaoi, Tachijakosou (thyme, Momoka), Tachidokoro (Hikai), Tachiyanagi, Tamarind `` seed '', Onion, tamshiba (hot spring),
Tara tree `` fruits, leaves, root bark '', Tarayou (large leaf winter blue, one leaf tea, bitter tea, bitter tea), dahlia (tenjikubotan), tarui, tanshiuchiwa, tanjin (dansin), dandelion (gakko British) or white dandelion or Moko dandelion, Danmar, Cherry `` fruit '', Chigaya `` fruit, root, bud '', chicory, chancapiedra (Kidachikomikansou), tulip, chocolate stay, kosensendai (daihaku),
Korean elm (Wuyi), Artemisia (Aoi leaf), Choreimaitake (Irei), Chorogi, Tsukimiso, Tsukushikakaneran, Tsukuritake (mushroom), Camellia, Camellia, Tsumekusa (lacquer primrose), Camellia (Duckweed), Tsuruazuki (red azuki bean), tsuldokudami (what is crow), camellia, daico, teuchigurumi, duberry `` fruit '', tengusa, tencha (tencha), tendaiyaku (crowd drug), touga (winter melancholy), toukagizura, capsicum (bancha), toukiki (Toki), Tokinsenka (marigold), Tonabena (river cut), corn or corn hair (Namba bark), horned rice mochi (female child), torindo or kosenrindo (dragon bile), tokusa (pirate), dokudami ( Ten drugs), Tokon
(Spot), Toshishi or Mamedaoshi or Pomegranate, Eucommia (Tonaka `` bark, leaves, roots ''), Ash (Qin bark), Tomato, Traganto, Triacanthus `` seed '', Tormentilla, Dronoki, Troloa oi, Tonkameme, Nijeria berry `` Fruit '''', Yam or yam (Yakuyaku), nagikadida (butcher bloom), naginata kouju, nazuna, rapeseed, natto bean or tatehaki (sword bean), nazumikan, jujube (daijutsu), nanawaibara (gold cherry tree), navena (continuous) , Nameko, peanut (peanut), nanten (minamitenmi), nambankarashi (ramie), odoris violet, nigaki
(Bitter tree), sagebrush (bitter mushroom), nutmeg, kei or nikkei or ceylon nikkei or yab nikkei (cinnamon bark) or keiseki (keishi), nymphalidium, leek (niko), elderberry
(Bone grafted `` fruits, flowers, stems, leaves ''), garlic (garlic), nurde (fivefold), leeks, nemoki or nebu or nebi or nemlinoki or digokubana (healing), thistle (ouji), neubara (real fruit), Nozuka Kazura (Liao Xia Hana), Nokotome, Yarrow, Nodake (Mae Hu), Novara, Pineapple `` Fruit '', Hibiscus (Bussouge, Furin Bussouge, Roselle), Hilindo, Hauchowa, Pau Dosse, Hakamauraboshi Hakusanburi, Hakusen (ringworm skin), Huckleberry "fruit",
Hazel (Haruko), Hasiridokoro (Rot root), Basil, Lotus (Lotus, Lotus, Lotus), Parsley (Netherland jelly), Naked worm, Batata, Hachik or Madake (Bamboo-boiled), Patchouli, Minka (Light load, Light load leaf) , Adlay (Yokuinin), Hanasuge
(Chimo), Banana, Hanamint, Hanabishi (Siturishi, Shisitsuri), Vanillabins, Papaya, Scotch (Rice malt grass), Pahalobobo, Hub `` Whole grass, stem, leaf '', paprika,
Hamakakiran, Hamago or Mitsuba Hamago (vine thorns),
Hamasuge (Kazukiko), Hamabishi (Situriko), Hamanas (Maikai flower), Hamabo fu (Hama windbreak), Hamamelis, Palm, Rose (Roses), Balata, Balata gum tree, Haratake
(Agaricus, White-faced Agaricus, Usukimori nokasa), Haran, Pariurus (Prunus avium), Parietaria, Harkanran, Balsamina (Tsurureishi, Nigari), Harunire (Yellow, Yule bark, Yuba), Barbasco, Harindou, Handaikai (Okai), Breadfruit, Hiougi (sun dried), Pecan nuts, Giganbana (Shirubi, Tsurugusha flower), Higurumadaria, Higotai, Hishi (Hisami), Pistachio, Beet, Hitotsuba (Stone reed), Aedes aegypti, Daisies ( Daisy), Hinata no Kozuchi (cow knees), Hinata bulbul, Hinoki, Hiba, Castor, Sunflower, Bell pepper, Himeuzu (Aoi), Himegama (Kaba), Himematsutake (Kawariharatake, Hiromatsutake), Himeyoran, Pimenta `` fruit '', Bakushi , Beakkyu, hiyu (fruit), below mallow, hirohakinagusa (white Okina), loquat "fruits, leaves, stems", betel nut (large clothing skin, betel palm), puerh tea (pu-cha), sprout kazura (southern rattan), butterbur, butterflies (winter flowers, winter leaves), wisteria ), Fuji Bean (flat bean), Fujimodoki (Church Cherry), grape "fruit, peel, seeds, leaves", beech, Fuyumushinatsukutake
(Caterpillar), Brazilian liquorice, black currant `` fruit '', blackberry, blanin, furcellaria, blueberry (Prunus avium), prunes, floral blanka, blond psyllium, bundou (green beans), hazelnuts, loofah, hetsukaran, safflower
(Safflower), Henneken, Belladonna, Berry `` fruit '', Persea, Perbianberg, Pereschia grandifolia, Benquisou or duckweed (Keiten), Boysenberry `` fruit '', Broomweed or Elderweed or Nendow or Haeukigi Kokia ), Hosairan, Balsam
(Hosen, acute child, osteophyte), Potteria sapota, Potteria lukuma, spinach, boufu (windbreak), spinach, physalis (Torone), honoki (wakopoku, park), bokeh
(Gourd), Hosoba Aburagiku (bitter gourd), Hosoba Oguruma,
Hosovanaokera (Aojutsu), Hosobanokirinsou (Kageten 37), Hosobabarengiku, Bodaiju (Bodaiju), Button
(Peony `` flowers, leaves, stems, bark ''), buttonpies (peony bark), hops, jojoba, borage (ruriichisha), bordeaux, white berries `` fruits '', hon-onik (meat porcelain, daigei), hon-sekko (iron Peeling stones, sparrow mountain stones), myzuruten nansha (Tennan star), maitake (maitake), ephedra (mao), maca, macadamia nuts, margaret (mokushungiku), macri (seaman grass), maguwa (mulberry white bark) `` Bark, leaves ''), Magnolia splengeri, Masaranpouba, Masaranzuba do Ceara, Masheira de Boi, Masahua (Tamanouzenhallen, Cucumber kinrenka), Matatabi (Kiten Tate), Matsukasa, pine `` leaves, bark, Roots, Matta Oryo, Matico (Cordoncillo), Mayorum (Hanamint), Malvanojazine (Difficult), Mulberry Fruits,
Quince, malein (belowed squid), mango,
Mangosteen, Mansagna (Andesca beetle), Mansuru walnut, Mandarin `` Fruit '', Mannentake (Lingzhi), Pheasant (Kikomi `` Fruit ''), Mishima saiko (Saiko), Mizuobako or Mizuasagao (Ryu tongoshi), Mizokoshi Lotus), misohagi (senkakuna), beet willow or elder willow
(Henshin), honeysuckle, honeysuckle, green sapote, green peppermint, mimosa, mioga, miracle fruit `` fruit '',
Myrrh, Myrobaran, Wheatwaragiku, Mukuge (Mokuge), Mukunoki, Mokuji (Extended Life Skin), Munya, Murasaki (Purple Root),
Purple or purple purple pearl, purple corn, purple purple (Kunming chicken blood wisteria), megakanza opuntica, mehajiki (mother grass), mebogi,
Melaloca, melissa, melilot, melon "fruit",
Mokusa mugwort, Moso bamboo, Mok giraffe, Moje (Gingerbush), Mochinoki, Mokko (wood incense), Momijibadaiou, peach (peach `` leaves, seeds, flowers, fruits ''), bean sprouts, morello cherries `` fruits '', Moroheiya (burlap) , Yakawamurasakiimo, yakuchi (masuchi), cornflower mackerel (cornflower), cornflower mint, yakon, yashabushi (arrow car) or himeyashabushi or giant yashabushi `` fruit, peel,
`` Kaho '', willow willow, yatsude (octagonal gold plate), mistletoe (parasitic willow), willow (kawayanagi, tayanyanagi, weeping willow, akameyanagi, pussy willow, inukoriyanagi, kinuyanagi, koryanagi, unryuyanagi, yamayanayagi, yamayanaginagi, yanagiyanagi, yamayanaginagi, yanagiyanagi, yamayanaginagi, yanagiyanagi, yamayanaginagi, yanagiyanagi, yamayanaginagi, yanagiyanagi, yamayanaginagi, yamayanaginagi, yamayanaginagi, yanagiyanaginayanagiyanagiyanagiyanagiyanagiyanagiyanagiyanagiyanagiyanagiyanagiyanagiyanagiyanagiyanagiyanaginayanagiyanagiyanagiyanagiyanagiyanagiyanagiyanagiyanagiyanagiyanagiyanagina.html) , Fox, willow)
Stalks ''
(Tsurusu, Tenmei), pokeweed (commercial land), yamanoki (yamaharu), yamamomo (yangmei), yamamogi, eucalyptus, yukinoshita (tiger ear grass), yucca or flefofolia, lily, yorogisa, mugwort , Rigan (Rainuma), lime "fruit", rye, lakanka "fruit", raspberry "leaf,
Fruits '', Latania (Crameria), Rakkyo or Shallot (Shoraku), Lavender, Longan (Longan flesh), Agave (Aono agave, Fukurin Agave), Ryokucha (green tea), Apple `` Fruits, seeds,
`` Leaves, roots '', gentian, rubus or suavisimus,
Ruritama thistle (Urajiro higotai, Xinjiang indigo head), litchi (Lichi, Lichi nucleus), lettuce (Chisha), red currant `` fruit '', red pitaya, lemon `` fruit '', lemongrass, forsythia or Chinese forsythia Lotus root, waxy plum, wax palm, lokon (reed, azuki),
Loganberry "Fruit", Rosemary (Mannenrow), Rosehip (Nobara), Wasabi, Cottonweed
(Mi Monka), Waremoko (Jiyu) and the like.

Also, other seawaters, for example, seawater salt, dried seawater, inorganic salts obtained from the Dead Sea or the Atlantic or Pacific Ocean (sodium chloride, magnesium chloride, potassium chloride, etc.), sea mud or mud (fango) , For example, sea mud or mud of various places such as Italian Fango, German Fango, Eifel Fango, Freiburg Fango, etc. (Ingredients: silicon dioxide, titanium dioxide, aluminum oxide, iron oxide, manganese oxide, sodium oxide, potassium oxide, magnesium oxide , Calcium oxide, strontium oxide, sodium, potassium, magnesium, calcium, chromium, iron, copper, nickel, zinc, lead, manganese, arsenic,
Wed), Shotoku stone etc.

As the seaweeds, seaweeds [green algae: Chlorella vulgaris, Chlorella pyrenoidsa, Chlorella ellipsoidia, Aonori (Usubaonori, Susiaonori, Hiraaonori, Bowaoonori, Hosoedaoonori), Anaaousa (Aousa) and the alga [Aosa] Kinds: Kombu (Macambu, Lysicum, Hosomekombu, Mitsuikonbu), Wakame, Hirome, Aookame, Giant Kelp (Macrocystis pilifera, Macrocystis integrifolia, Neocitys luetokeana), Hijiki, Hibamata, Umiuchiwa, Usubaumiuchiwa Klebanoumi prickly pear, Akaba prickly pear, Kona prickly pear, Okina prickly pear, Usuki prickly pear, Echinoki prickly pear], seaweed [red algae: red alga: Hijirimen, maxa (Tengusa), hirakusa, oniku , Obakusa, Kataobakusa,
Yatabegusa, Yuikiri, Shimatengusa, Tosakanori, Togekirinsai, Akumasakirinsai, Kirinsai, Juniperus giraffe, Tsunomata, Obatsunomata, Tochaka (Yahatsutsunomata), Ezotsunomata, Togetsunomata, Hirakotonota, Kotoji, Kotojita
Jareus Banori, Kagius Banori, Siusius Banori, Hyus Banori, Akamomininori] and the like.

Other algae, for example, green algae (Chlamydomonas: Chlamydomonas, Akayukimo, Dunaliella: Dunaliella, Chlorococcus: Chlorococcus, Kwanomimo: Kwanomimo, Volvox: Ohikawawari, Volvox, Palmera, Yotsumemo, Spirogyra: Hizaori, Spirogyra, Tsurugimidro, Hibimidoro: Hibimidoro, Aosa: Anaoasa, Amiosa, Nagaosa, Kawanori: Kawanori,
Genus Fricciella, genus genus: magnolia, asamidorigusa, kawashiogusa, marimo, valonia: tamagobaronia, tamabaronia, magnum: agatamagu, iwata: husaiwata, suricogita, heraiwata, crocodile, crocus Sakibuchimil, Nagamir, Hiramil, and Casanori:
Casanori, Jusmo: Fusuzumo, Tamazumi,
Species of the genus Mizodzumo, genus Genus, genus Colecaetus, genus Ceratophylla, genus Ceratopogon: Rubiaceae, Rana genus: Rana genus, Hirano-Hana, Rana genus, Rhizophora, Genus genus, etc.

Cyanobacteria (Genus L .: L., L., L., L .: L., mushrooms,
(Hassay, genus genus, genus racenmo (spirulina): spirulina, genus trichodesmium (aiakacio), etc.).

Brown algae (Piraella spp .: Piraella spp., Spirogyra spp.
Isogawara genus: Isogawara, Kuroshira genus: Gunsenkurogashira, Kashirazaki genus: Kashirazaki, Muchimo genus: Muchimo, Hiramutimo, Kebelligsa, Amidixa genus: Amidigusa, Sakibiroamiji, Sanadagusa: Sanadagusa, Fukurinamiji, Common genus: Artemisia spp.
Genus genus: genus pine, genus genus: genus genus: genus genus, genus okinawa, genus okinawa mozuku, genus nov. Ishige, Irolo, Icmegasa: Ichimegasa, Keyari: Keyari, Umibos: Umibos, Urushigusa: Ursigusa,
Species of Coleoptera, Tobacco moss, Laminaria spp. Genus Kagomenori: Kagomenori, Muraridori: Murachidori, Shakusugusa: Sharks
Genus Genus: Genus Genus, Genus Genus: Genus Genus: Genus Genus, Genus Kayamonori, Genus Kayamono, Genus Genus: Genus Ligustrum, Genus Tsurumo: Genus Tsurumo, Genus Anana: Genus Anastasia, Genus Suzume: Genus Missiscoma: Genus Missiscoma, Atsubumikonga, Kossula , Oni-kombu, Gohei-kombu, Naga-kombu, Pea-kombu, Ochimitsu-kombu, Toro-kombu genus: Toro-kombu, Antokume genus: Antokume, Kajime genus: Kajime, Tsuruarame, Kurome, Kikuishicombe genus: Kikuishicomb, Nejirekombu: Nekorecome, Kuroshimeo : Nekoshikonbu,
Alame: Alame, Ainuwakame: Ainuwakame, Chigaiso, Oniwakameezoishige: Ezoishige, Yabanemoku: Yabanemoku, Rapamoku: Rapamoku, Jiromoku: Uganomok, Jiromoku, Hiemomoku, Hokumoku, Tamamomoku Akamoku, Shidamoku, Hondawara, Nejimoku, Narasamo, Mametarawara, Tatsukuri, Yasumatamoku, Umitrano, Oobamoku, Fushizushimoku, Hahakimoku, Togemoku, Jolemoku, Saw-mokum, Obanoki-mimoku, Genus genus:
Bulumimo, genus cynomolgus: cynomolgus etc.).

Red algae (Russia genus: Bovine genus, Funorinoshike, Amanori genus: Asakusanori, Susabinori,
Genus Upirinori, Onimanori, Tasa, Filitasa, Benitasa, Rhodocorton: Milnoveni, Akebonomozuku: Akebonomozuku, Konahada: Haikonahada, Yogorekonahada, Aokonahada, Sea Species: Acacia sylvestris, Ochryllidae, Larvae genus : Larch, Fusanori: Fusanori, Nisefusanori: Nisefusanori,
Sodegarami: Sodegarami, rattles: Rattle, Hiragaragara, Hirohatamataki: Hirohatamaitadaki, Tamaitadaki: Tamaitadaki, Kakenokenori: Kaginori, Kakenenori, Tengusa: Himetengusa, Hitenugusa, Hitenugusaobana, Hitennakuobusa, Hitenuganugusa, Hitenugusaugou Genus: hibiroudo, himebiroudo,
Genus Isomomedogi: Genus Isomomedo, Genus genus: Genus genus, Ryumonsou: Ryumonsou, Hera Ryumon, Nisekarekigusa: Nisekaregusa, Okutsubara: Oba Otsubara, Akaba: Akaba, Malvaacaba, Naminohana genus
Naminohana, coral genus: rattles, genus cynosporium: shiogosagoromo, genus iwanokawa: esukiiwanokagawa, genus kainokawa: genus kainokawa: kaninote, genus coral: coral genus, coral mosquito, mosquito mosquito , Tambanori, slippery,
Fudarak, Malbahudarak, Isonohana: Nuracusa,
Black skull, scorpion scorpion, squash genus: squamous ibis, scorpion genus: scorpion genus: scorpion sculpture: chabo kintoki, squash, matsunori, komenori, tosakamatsu, tsutsumatsu, fushikintoki, tsunomukade, swordfish, swordfish, saccharomyx, skullfish Nagaobabane: Nagaobane,
Genus Funori: Hanafunori, Fukuronori, Makunori, Karenikusa: Kalexigusa, Tosokamodoki: Hosobanotosakamaki, Hirohanokasudo, Yatsudegatatosakamoki, Kurosakamoka, Nezashinotosakanodoka, Yukasinosa Modoki,
Genus genus: genus genus: genus: kinuhada, genus ezotosaka: genus ezotosaka, genus tsukasanori: genus california, giant porpoise, genus hagano genus: genus honoo, genus genus: genus lycopodium, genus genus Susqueke Beni, Okamuragusa:
Yamadagusa, Mirin genus: Mirin, Hosobamilin, Tosakanori genus: Kikutosaka, Ezonameshi: Ezonameshi, Isomokka genus: Isomocca, Yukari genus: Yukari, Hosoyukari, Ibaranori genus: Ibaranori, Saidaibara, Tachiibara, Kagiinobalon, Kijunio genus Isanthus, Atsubanori: Atsubanori,
Ogonori: Ogonori, Tsurusilamo, Shiramo, Ogogonori, Mizookonori, Kabanori, Beniogonori, Fucresinori, Murasakikabanori, Shinkaikabanori, Togekabanori, Kataogonori, Ryukyuogonori, Ryokyuogonori, Ryukyuogonori, Ryukyuogonori, Ryokyuogonori , Genus Asteraceae: Hachijoenagasomodo, Fushikenori genus: Fushikenori, Namiiwatake genus: Namiiwatake, scorpion genus: Scorpion genus, Occidental genus: Okutsunori, Saimi genus: Itanigusa, Simi, Harigane, Lotus japonicus:
Lotus lotus, genus genus: squid
Nobonori, Black Snapper genus: Black Snapper, Red Snapper genus: Red Snapper, Hishbukuro genus: Hishbukuro, Madaragusa genus: Togemadara, Echimadara, Taoyagusa genus: Taoyagousou, Hanasakura, Saga-no-nagusa , Hirata goat: Hirata goat, Darus: Darus, Masagoshibari, Anadals, Uebagsa: Uebagsa, Benifukuronori: Benifukuronori, Fushitsuna: Fushitsunagi, Himefushinagi,
Species of the genus Hirohafushi and Snapdragons: Snapdragons, Snapdragons, Species: igis, keiigis, crickets, nigiri, amixa, egonori:
Egonori, Futogigis, Saeda: Saeda, Chrysanthemum: Chrysanthemum, Konohanori: Habtaenori, Konohanori, Suzushironori, Usveni: Usveni, Hasuginu: Hasuginu, Nagakonohori: Nagakosugino, Genus suginanu, Hana Yaleusbanori, Sujiusbanori, Hyusbanori, Usubanorimodoki genus: Usubanorimodoki, Ayanishiki: Ayanishiki, Ayaginu:
Ayaginu, Dassia Genus: Enashidazia, Shimadada Genus: Isohagi, Shimadadaji, Dazimodoki Genus: Dazimomodoki, Itogusa Genus: Moletogusa, Futonigusa, Macri Genus: Macri, Salixinus Genus: Hanayanagi, Yuna, Sanagiginori, Mosanyugina, Genus : Kurozozo, Kobusoso, Hanezozo, Sozonohana, Hanegusa: Hanegusa, Kanegusa, Kozanemo: Kozanemo, Isomurasaki, Hosokozanemo, Himegoke: Himegoke, Kurohimegoke, Hyodosigus, Genus genus Suginasugusa, Isobasho Genus: Isobasho, Fujimatsumo Genus: Fujimatsumo, Sawtooth Lilium: Hatakesakinokokihiba, Kawamozuku: Kawamozuku, A Kawamozuku, Himekawamozuku,
Ideyugogome: Ideyugogome, Okitimozuku: Okitimozuku, Itogusa, Chinorimo: Chinorimo, Chisginori: Chisinori, etc.).

The axle algae (Characta spp.
Hossiturimo: Hossiturimo, Lichnotumnus, Flasks: Himefuramo, Chaboflasmo, Tripella etc., and yellow algae (Hikarimo: Hikarimo etc.).

Materials derived from animal raw materials include cockscomb extract, bovine or swine, human placenta extract, swine or bovine stomach, duodenum or intestinal extract or decomposed product thereof, and bovine or swine spleen. Extract or its degradation product, bovine or porcine brain tissue extract, water-soluble collagen, collagen derivatives such as acylated collagen, collagen hydrolyzate, elastin, elastin hydrolyzate, water-soluble elastin derivative,
Keratin and its degradation products or their derivatives, silk protein and its degradation products or their derivatives, swine or bovine blood cell protein degradation products (globin peptides), bovine or swine hemoglobin degradation products (hemin, hematin, heme, protohem, Heme iron), milk, casein and its decomposition products or their derivatives, skim milk powder and its decomposition products or their derivatives, lactoferrin or its decomposition products, chicken egg components, fish meat decomposition products, nucleic acid-related substances (ribonucleic acid, deoxyribonucleic acid) )etc.

(14) Microbial culture metabolite Yeast metabolite, yeast extract, natto metabolite, natto extract, rice ferment extract, rice bran (red bran, white bran) ferment extract, euglena extract, raw milk or skim milk powder Lactic acid fermentation products, trehalose or derivatives thereof.

(15) α-hydroxy acids glycolic acid, citric acid, malic acid, tartaric acid, lactic acid and the like.

(16) Inorganic pigments Silicic anhydride, magnesium silicate, talc, kaolin,
Bentonite, mica, titanium mica, bismuth oxychloride, zirconium oxide, magnesium oxide, zinc oxide,
Titanium oxide, calcium carbonate, magnesium carbonate, yellow iron oxide, red iron oxide, black iron oxide, gunjou, chromium oxide,
Chromium hydroxide, carbon black, calamine, etc.

(17) UV absorbing / blocking agent benzophenone derivatives (2-hydroxy-4-methoxybenzophenone, 2-hydroxy-4-methoxybenzophenone-
5-sulfonic acid, 2-hydroxy-4-methoxybenzophenone-5-sulfonic acid sodium salt, dihydroxydimethoxybenzophenone, sodium dihydroxydimethoxybenzophenone-sulfonic acid salt, 2,4-dihydroxybenzophenone, tetrahydroxybenzophenone, etc.), p-aminobenzoic acid Derivatives (paraaminobenzoic acid, ethyl paraaminobenzoate, glyceryl paraaminobenzoate, amyl paradimethylaminobenzoate, octyl paradimethylaminobenzoate), methoxycinnamic acid derivatives (ethyl paramethoxycinnamate, isopropyl paramethoxycinnamate,
Octyl paramethoxycinnamate, 2-ethoxyethyl paramethoxycinnamate, sodium paramethoxycinnamate, potassium paramethoxycinnamate, mono-2-diparamethoxycinnamate
Glyceryl ethylhexanoate, etc.), salicylic acid derivatives (octyl salicylate, salicylphenyl, homomenthyl salicylate, dipropylene glycol salicylate, ethylene glycol salicylate, myristyl salicylate,
Methyl salicylate), anthranilic acid derivatives (methyl anthranilate), urocanic acid derivatives (urocanic acid, ethyl urocanate, etc.), coumarin derivatives, amino acid compounds, benzotriazole derivatives, tetrazole derivatives, imidazoline derivatives, pyrimidine derivatives, dioxane derivatives , Camphor derivative, furan derivative, pyrone derivative, nucleic acid derivative, allantoin derivative, nicotinic acid derivative, vitamin B6 derivative, umbelliferone, esculin, benzyl cinnamate, sinoxate, oxybenzone, dioxybenzone, octabenzone, slisobenzone, benzoresorcinol, arbutin Guaiazulene, shikonin, baicalin, baicalein, berberine, neoheliopan, escalol, zinc oxide, talc, kaolin and the like.

(18) Whitening agent p-aminobenzoic acid derivative, salicylic acid derivative, anthranilic acid derivative, coumarin derivative, amino acid compound,
Benzotriazole derivatives, tetrazole derivatives, imidazoline derivatives, pyrimidine derivatives, dioxane derivatives, camphor derivatives, furan derivatives, pyrone derivatives,
Nucleic acid derivatives, allantoin derivatives, nicotinic acid derivatives,
Vitamin C or its derivatives (vitamin C phosphate magnesium salt, vitamin C glucoside, etc.), vitamin E or its derivatives, kojic acid or its derivatives, oxybenzone, benzophenone, arbutin, guaiazulene, shikonin, baicalin, baicalein, berberine, placenta extract , Ellagic acid, lucinol and the like.

(19) Tyrosinase activity inhibitor Vitamin C or a derivative thereof (vitamin C phosphate ester magnesium salt, vitamin C glucoside or the like), hydroquinone or a derivative thereof (hydroquinone benzyl ether or the like), kojic acid or a derivative thereof, vitamin E or Derivatives thereof, N-acetyltyrosine or derivatives thereof, glutathione, hydrogen peroxide, zinc peroxide, placental extract, ellagic acid, arbutin, rucinol, silk extract, plant extract (chamomile, mulberry, gardenia, touki, waremokou,
Clara, mugwort, honeysuckle, yellowfin, yellowtail, pine cone, pearl barley, pearl bark, hops, hawthorn, eucalyptus, achillea millefolium, artea, calyx, mankeishi, hamamelis, yamaguwa, extended life grass, bellflower, toshishi, maizeko, sun dried, mao, (Sengyu, Dokkatsu, Psycho, Bohu, Hamabofu, Ogon, Peony, Peony, Genoshoko, Kakkon, Licorice, Gotobiko, Aloe, Shouma, Safflower, Green Tea, Black Tea, Asenyaku).

(20) Melanin pigment reduction / decomposition substance Phenylmercury hexachlorophene, mercuric oxide, mercurous chloride, aqueous hydrogen peroxide, zinc peroxide, hydroquinone or a derivative thereof (hydroquinone benzyl ether)
etc.

(21) Turnover promoting action / cell activator hydroquinone, lactic acid bacteria extract, placenta extract, reishi extract, vitamin A, vitamin E, allantoin, spleen extract, thymus extract, yeast extract, fermented milk extract, plant extract (Aloe, Ogon, Horsetail, Gentian, Burdock,
Sicon, carrot, hamamelis, hop, yokunin,
Odorikosou, Assemblage, Touki, Tokinsenka, Amacha, Hypericum, Cucumber, Periwinkle,
Rosemary, parsley) etc.

(22) Astringent succinic acid, allantoin, zinc chloride, zinc sulfate, zinc oxide, calamine, zinc p-phenolsulfonate, aluminum potassium sulfate, resorcinol, ferric chloride, tannic acid (including catechin compound) etc.

(23) Active oxygen scavenger SOD, catalase, glutathione peroxidase and the like.

(24) Antioxidants Vitamin C or a salt thereof, stearic acid ester, vitamin E or a derivative thereof, nordihydroguaselethenoic acid, butylhydroxytoluene (BHT), butylhydroxyanisole (BHA), hydroxytyrosol, Parahydroxyanisole, propyl gallate, sesamol,
Sesamolin, gossypol, propolis, etc.

(25) Lipid peroxide production inhibitor β-carotene, plant extract (cultured sesame cells, amateur,
Hypericum, Hamamelis, Clove, Melissa, Emisoso, Birch, Salvia, Rosemary, Minami Tenji, Agetsu, Ginkgo, Green Tea) and the like.

(26) Anti-inflammatory agent Ictamole, indomethacin, kaolin, salicylic acid, sodium salicylate, methyl salicylate, acetylsalicylic acid, diphenhydramine hydrochloride, d-camphor,
dl-camphor, hydrocortisone, guaiazulene, camazulene, chlorpheniramine maleate, glycyrrhizic acid or a salt thereof, glycyrrhetinic acid or a salt thereof, licorice extract, sicon extract, age extract extract, propolis and the like.

(27) Antibacterial, bactericidal and disinfecting agents acrinol, sulfur, calcium gluconate, chlorhexidine gluconate, sulfamine, mercurochrome, lactoferrin or a hydrolyzate thereof, alkyl diaminoethyl glycine chloride solution, triclosan, sodium hypochlorite, Chloramine T, salad powder, iodine compound,
Iodoform, sorbic acid or a salt thereof, salicylic acid, dehydroacetic acid, parahydroxybenzoic acid esters, undecylenic acid, thiamine lauryl sulfate, thiamine lauryl nitrate, phenol, cresol, p-chlorophenol, p-chloro-m-xylenol, p-chloro-m-cresol, thymol, phenethyl alcohol, o-phenylphenol, irgasan CH3565, halocarban, hexachlorophen, chlorohexidine, ethanol, methanol, isopropyl alcohol, benzyl alcohol, ethylene glycol, propylene glycol, phenoxyethanol, chlorobutanol, Isopropyl methyl phenol, nonionic surfactants (polyoxyethylene lauryl ether, polyoxyethylene nonyl phenyl ether, polyoxyethylene Octyl phenyl ether, etc.), amphoteric surfactants, anionic surfactants (sodium lauryl sulfate, potassium lauroyl sarcosine, etc.),
Cationic surfactants (cetyltrimethylammonium bromide, benzalkonium chloride, benzethonium chloride, methylrosaniline chloride), formaldehyde, hexamine,
Brilliant Green, Malachite Green, Crystal Violet, Jarmal, Photosensitizer No. 101, Photosensitizer No. 201, Photosensitizer No. 401, N-long-chain acyl basic amino acid derivatives and their acid addition salts, zinc oxide, hinokitiol, kudin, propolis, etc. .

(28) Humidifier Glycerin, propylene glycol, 1,3-butylene glycol, hyaluronic acid or its salt, polyethylene glycol, chondroitin sulfate or its salt, water-soluble chitin or chitosan derivative, pyrrolidone carboxylic acid or its salt, lactic acid Sodium, Mini Sasanishiki extract, Bacillus natto metabolite, Bacillus natto extract, Loofah water, Birch (birch) or Akamatsu sap

(29) Elastase activity inhibitor diisopropyl fluorophosphate, plant extracts (Ougon, Hypericum perforatum, Clara, mulberry leaves, calyx, gennoshoko, comfrey, salvia, Atlantic elderberry, bollige, buttonpi), seaweed extract and the like.

(30) Hair Agents Selenium disulfide, alkylisoquinolinium bromide solution, zinc pyrithione, biphenamine, thianthol, castal tincture, ginger tincture, capsicum tincture, quinine hydrochloride, strong aqueous ammonia, potassium bromate, bromate Sodium, thioglycolic acid and the like.

(31) Antiandrogens Estrogen (estrone, estradiol, ethinylestradiol, etc.), isoflavones, oxendrones, etc.

(32) Peripheral vascular blood flow promoter Vitamin E or a derivative thereof, assembly extract, garlic extract, carrot extract, aloe extract, gentian extract, touki extract, cepharanthin, carpronium chloride, minoxidil and the like.

(33) Stimulant Pepper tincture, vanylamide nonylate, tincture tincture, tincture tincture, peppermint oil, l-menthol, camphor, benzyl nicotinate and the like.

(34) Metabolic activators Photosensitizer 301, hinokitiol, pantothenic acid or derivatives thereof, allantoin, placental extract, biotin, pentadecanoic acid glyceride and the like.

(35) Antiseborrheic agent pyridoxine or a derivative thereof, sulfur, vitamin B6
etc.

(36) Keratolytic agent Resorcin, salicylic acid, lactic acid and the like.

(37) Oxidizing agent Hydrogen peroxide solution, sodium persulfate, ammonium persulfate, sodium perborate, urea peroxide, sodium percarbonate, sodium tripolyphosphate, sodium bromate, potassium bromate, pyrroline peroxide Sodium silicate, sodium orthophosphate, sodium silicate hydrogen peroxide adduct, sodium sulfate hydrogen peroxide adduct, sodium chloride hydrogen peroxide adduct, β-tyrosinase enzyme solution,
Mushroom extract and the like.

(38) Hair remover strontium sulfate, sodium sulfide, barium sulfide,
Inorganic reducing agents such as calcium sulfide; thioglycolic acid or salts thereof (calcium thioglycolate, sodium thioglycolate, lithium thioglycolate, magnesium thioglycolate, strontium thioglycolate) and the like.

(39) Hair swelling agent Ethanolamine, urea, guanidine and the like.

(40) Dyes 5-aminoorthocresol, 2-amino-4-nitrophenol, 2-amino-5-nitrophenol, 1-amino-4-methylaminoanthraquinone, 3,3'-iminodiphenol ,
2,4-diaminophenoxyethanol hydrochloride, 2,4-diaminophenol hydrochloride, toluene-2,5-diamine hydrochloride, nitroparaphenylenediamine hydrochloride, paraphenylenediamine hydrochloride, N-phenylparaphenylenediamine hydrochloride, metaphenylenediamine hydrochloride, ortho Aminophenol, N-phenylparaphenylenediamine acetate, 1,4-diaminoanthraquinone, 2,6-diaminopyridine, 1,5-dihydroxynaphthalene, toluene-2,5-diamine, toluene-3,4-
Diamine, nitroparaphenylenediamine, paraaminophenol, paranitroorthophenylenediamine, paraphenylenediamine, paramethylaminophenol,
Picramic acid, sodium picramate, N, N'-bis (4-aminophenyl) -2,5-diamino-1,4-quinonediimine, 5- (2-hydroxyethylamino) -2-methylphenol, N-phenyl Paraphenylenediamine, metaaminophenol, metaphenylenediamine, 5-aminoorthocresol sulfate, 2-amino-5-nitrophenol sulfate,
Orthoaminophenol sulfate, orthochloroparaphenylenediamine sulfate, 4,4'-diaminodiphenylamine sulfate, 2,4-diaminophenol sulfate, toluene-2,5-sulfate
Diamine, nitroparaphenylenediamine sulfate, paraaminophenol sulfate, paranitroorthophenylenediamine sulfate, paranitrometaphenylenediamine sulfate, paraphenylenediamine sulfate, paramethylaminophenol sulfate, metaaminophenol sulfate, metaphenylenediamine sulfate, catechol, diphenylamine , Α-naphthol, hydroquinone, pyrogallol, phloroglucin, gallic acid, resorcin, tannic acid, 2-hydroxy
Sodium 5-5-nitro-2 ', 4'-diaminoazobenzene-5'-sulfonate, hematein and the like.

(41) Flavors Natural animal flavors such as musk, civet, castorium, ambergris, anise essential oil, angelica essential oil, ylang-ylang essential oil, iris essential oil, fennel essential oil, orange essential oil, cananga essential oil, caraway essential oil, cardamom essential oil, Guayakwood essential oil, cumin essential oil, black letter essential oil, cinnamon essential oil, cinnamon essential oil, geranium essential oil, copaiba balsam essential oil, Coriandel essential oil, perilla essential oil, cedarwood essential oil, citronella essential oil, jasmine essential oil, gingergrass essential oil, cedar essential oil, spearmint essential oil, western Mentha essential oil, Greater Fengxiang essential oil, Tuberose essential oil, T-shaped essential oil, Orange flower essential oil, Winter green essential oil, Truval sam essential oil, Batturi essential oil, Rose essential oil, Palmarosa essential oil, Cypress essential oil, Hiba essential oil,
Sandalwood essential oil, Petit glen essential oil, Bay essential oil, Vetiva essential oil, Bergamot essential oil, Peruvian balsam essential oil, Boad rose essential oil, Camphor essential oil, Mandarin essential oil, Eucalyptus essential oil, Lime essential oil, Lavender essential oil, Linaloe essential oil, Lemongrass essential oil, Lemon essential oil, Rosemary Essential oils, vegetable flavors such as Japanese peppermint essential oils, and other synthetic flavors.

(42) Dyes and Colorants Red Cabbage Dye, Red Rice Dye, Akane Dye, Anato Dye, Ikasumi Dye, Turmeric Dye, Endu Dye, Krill Dye, Persimmon Dye, Caramel, Gold, Silver, Gardenia Dye, Corn Dye , Onion pigment, tamarind pigment, spirulina pigment, buckwheat whole plant pigment, cherry pigment, laver pigment, hibiscus pigment, grape juice pigment, marigold pigment, purple potato pigment, purple yam pigment, lac pigment, rutin and the like.

(43) Sweeteners Sugar, sweet tea, fructose, arabinose, galactose, xylose, stevia, mannose, maltose, honey, glucose, miraculin, monelin, licorice extract and the like.

(44) Nutrition Enhancer Shell calcined calcium, cyanocorabamine, yeast, wheat germ, egg yolk powder, hemicellulose, heme iron and the like.

(45) Dairy products Milk, cheese, fresh cream, butter, margarine, milk powder, whey, condensed milk and the like.

In addition, humectants, hormones, sequestering agents, pH adjusters, chelating agents, preservatives / anti-binders, fresheners, stabilizers, emulsifiers, animal and vegetable proteins and their decomposed products, animal and vegetable Plant polysaccharides and their degradation products, animal and plant glycoproteins and their degradation products, blood flow promoters, anti-inflammatory agents, anti-inflammatory agents, anti-allergic agents, cell activators, keratolytic agents, wound healing agents, foaming Ingredients, thickeners, oral agents, deodorants / deodorants, bitters, seasonings, enzymes, etc., and components having the Maillard reaction inhibitor of the present invention and the Maillard reaction inhibitor known to date Depending on the combined use, an additive or synergistic Maillard reaction inhibitory action can be expected.

Further, the dosage form of the Maillard reaction inhibitor, cosmetic composition or food or drink of the present invention is arbitrary, and capsules, powders, granules, solids, liquids, gels, bubbles, emulsions, creams,
It can be used in the form of an ointment, a sheet or the like.

Specifically, for example, pharmaceutical preparations for internal and external use, basic cosmetics such as lotions, emulsions, creams, ointments, lotions, oils, packs, facial cleansers and skin cleansers, hair removers, depilatory , After-shave lotion, pre-show lotion, shaving cream, foundation, makeup cosmetics such as lipstick, blusher, eyeshadow, eyeliner, mascara, perfume, nail polish, nail enamel, nail enamel remover, shampoo, Rinse, hair treatment, pre-hair treatment, hair styling, perm agent, hair tonic, hair dye, hair growth and hair restoration, hair cosmetics, bath agent, deodorant, deodorant, cataplasm,
It can be applied to various products such as plasters, tapes, sheets, patches, aerosols, toothpastes, mouth fresheners / gargles, sanitary cotton, wet tissues, etc.
It can be used for general food and drink.

The method of adding to the Maillard reaction inhibitor, the cosmetic composition or the food or drink of the present invention may be added in advance or during the production, and may be appropriately determined in consideration of workability. Just choose.

[0091]

EXAMPLES The present invention will now be described with reference to production examples, test examples, and prescription examples, but the present invention is not limited to these examples.

(Production Example 1) Akebi, aloe, apricot, hippo, kikyo, goshi, panax ginseng, taukogi,
100 g of each dried plant of Narco lily, Hakobe, Hamajisha, Bukuryo and Yuzu is immersed in 1 L of purified water (about 80 ° C),
Extracted with heating (dry solid content: approx. 0.1%)
~ 2.5%).

(Production Example 2) Akebi, aloe, apricot, hippopotamus, kikyo, goshi, panax ginseng, taucogi,
100 g of each dried plant of Narco lily, Hakobe, Hamajisha, Bakuryo and Yuzu is immersed in 1 L of a 50% ethanol solution, extracted at room temperature for 7 days, and then filtered to obtain an extract (dry solid content: about 0.1 to 2.5%). Get about 1.0kg.

(Production Example 3) Akebi, Aloe, Apricot, Hippo, Kikyo, Gomushi, Panax ginseng, Taukogi,
100 g of each dried plant of Narco lily, Hakobe, Hamajisha, Bukuryo and Yuzu in 50% 1,3-butylene glycol solution 1L
And extracted at room temperature for 7 days, and then filtered to obtain about 1.0 kg of an extract (dry solid content: about 0.1 to 2.0%).

(Production Example 4) Akebi, Aloe, Apricot, Hippo, Kikyo, Gomushi, Panax ginseng, Taukogi,
100 g of each dried plant of Narco lily, Hakobe, Hamajisha, Bukuryo and Yuzu in 50% 1,3-butylene glycol solution 1L
After extraction at 50 ° C. for 3 days and nights, the solvent was distilled off, and the obtained pasty substance was redissolved in a 30% 1,3-butylene glycol solution, and subjected to suction filtration to obtain an extract (dry solid content). 0.1 ~
2.0%) about 1.0 kg.

(Production Example 5)
100 g of each dried plant of Narco lily, Hakobe, Hamajisha, Bukuryo and Yuzu is immersed in a 50% propylene glycol solution, extracted at room temperature for 5 days and nights, and then filtered to obtain an extract (dry solid content: about 0.1 to 2.5%). Get about 1.0kg.

(Production Example 6) Akebi, aloe, apricot, hippo, kikyo, gomushi, panax ginseng, taukogi,
100 g of each dried plant of Narco lily, Hakobe, Hamajisha, Bukuryo and Yuzu is immersed in 1 L of purified water (about 30 ° C.), extracted at room temperature for 5 days and nights, filtered and extracted (dry solids:
About 0.1-2.0%).

(Test 1) Measurement of Inhibitory Effect on Maillard Reaction (Terminal Saccharified Substance Formation) The Maillard reaction (browning reaction) is a non-enzymatic protein saccharification reaction. This is a bond between an amino acid or protein controlling various physiological functions in a living body and a reducing sugar, and forms a yellow-brown substance. The initial stage reactant of the Maillard reaction is a protein-sugar conjugate called an Amadori compound. Furthermore, this reaction forms a yellow-green substance having fluorescence through dehydration and polymerization. This is called advanced saccharified substance. This series of reactions is known to impair the function of the protein and to form intra- and intermolecular cross-links of the protein. This advanced saccharified substance (Final product of Maillard reaction)
The inhibitory effect was evaluated by comparing the inhibition rate (%) of the formation of pentosidine, which is one of them.

"Test Method and Evaluation Method" a. Sample The extract obtained in Production Example 2 of the present invention was used for a test. A 50% ethanol solution was used as a blank, and 1 mM and 10 mM aminoguanidine were prepared under the same conditions as a positive control and used for the test. b. Measurement of Pentosidine Production Inhibition Effect 500 mM Ribose, 500 mM Lysine, 500 mM A in 10 μL of sample solution
rginine, 100 mM Na ₂ HPO ₄ (pH 7.4), H ₂ O was added 100 μL each,
After incubation on a heat block at 60 ° C. for 24 hours, after the reaction was completed, 400 μL of H ₂ O was added to 100 μL of the reaction solution, and the amount of Pentosidine produced was measured by high performance liquid chromatography.

<High-performance liquid chromatography measurement conditions>
The solvent used was acetonitrile: TFA: H ₂ O = 3: 0.1: 96.9. Flow rate 1 mL / min, column temperature 40 ° C, excitation wavelength 335
nm and the measurement wavelength is 380 nm. Injection volume is 1
Perform with 0 μL. In addition, the pentosidine (pentosidine) standard is M
Adjustments were made based on Onnie's method and confirmed by various instrument spectrum data. It was used to confirm that the peak on the high performance liquid chromatogram was pentosidine.

[0101]

(Test Results) As shown in Table 1, each of the plant extracts of the present invention, Akebi, Aloe, Apricot, Hippopotamus, Kikyo, Gomushi, Sanshin ginseng, Taukogi, Narco lily, Hakobe, Hamajisha, Bukuryo, and Yuzu is as follows. Although it has a slight difference, it has been confirmed that it has a pentosidine production inhibitory action, which is a Maillard reaction final product almost the same as aminoguanidine, and can be used as a Maillard reaction inhibitor.

(Test 2) Safety test (1) Primary skin irritation test Each of the plant extracts obtained in Production Examples 1 to 6 was prepared with purified water so that the dry solid concentration was about 0.5%. , Japanese white rabbit with shaved back (female, 3 per group, weight around 2.3kg)
Was applied to the skin. At 24, 48 and 72 hours after application, evaluation was performed using erythema and edema as indices based on the criteria of Draize. As a result, no erythema and edema were observed in all animals, and it was judged that there was no problem with regard to primary skin irritation.

(Test 3) Safety Test (2) Skin Cumulative Irritation Test Similarly, each of the plant extracts obtained in Production Examples 1 to 6 was purified water-purified so that the dry solid concentration was about 0.5%. Hartley guinea pigs prepared and shaved on the back (female, 3 per group,
0.5 mL / animal was applied to the skin once a day, 5 times a week, on the skin of about 320 g in weight). Application was performed over two weeks and shaving was performed on the last application day of each week. Evaluation was performed using erythema and edema as indices based on the criteria of Draize on each application day and the day after the last application day. As a result, no erythema or edema was observed in any of the animals for 2 weeks, and it was judged that there was no problem with respect to the cumulative skin irritation.

(Test 4) Safety test (3) Single dose toxicity test Each plant extract obtained in Production Examples 1 to 6 was adjusted with purified water to a concentration of 12.5%. kg of ddy mice (male and female,
Oral administration was carried out to a group of 5 mice, 5 weeks old), and the appearance and degree of toxicity symptoms were observed over time. As a result, no abnormality was observed in all the mice for 14 days, and no abnormalities were found in the dissection results. Therefore, the LD50 was 2,000 mg / kg or more, and it was determined that the substance was safe.

(Prescription Examples) Production of Maillard Reaction Inhibitor, Cosmetic Composition or Food and Beverage In accordance with the above evaluation results, the following prescription examples are shown below. And only the amount was shown. Further, the present invention is not limited to these.

(Formulation Example 1) Emulsion weight% 1. Squalane 5.0 2. Olive oil 5.0 3. Jojoba oil 5.0 4. Cetyl alcohol 1.5 5. Glycerin monostearate 2.0 6. Polyoxyethylene (20) cetyl ether 3.0 7. Poly Oxyethylene (20) soorbitan monooleate 2.0 8.1,3-butylene glycol 1.0 9. Glycerin 2.0 10. A: Akebi extract of Production Example 2 B: Aloe extract of Production Example 2 C: Apricot extraction of Production Example 2 Product D: Hippopotamus extract of Production Example 2 E: Kikyo extract of Production Example 2 F: Dust extract of Production Example 2 G: Panax ginseng extract of Production Example 2 H: Tawkogi extract of Production Example 2 I: Extract of Narco Lily of Production Example 2 J: Extract of chickweed of Production Example 2 K: Extract of Anopheles japonica of Production Example 2 L: Extract of Bakuryou of Production Example 2 M: Yuzu extract of Production Example 2 * A to M One extract 5.0 11. Preservative (Paraoxybenzoates) qs 12. Residual to Perfume qs 13. Purified water 100

(Formulation Example 2) Emulsion Weight% 1. Squalane 8.0 2. Jojoba oil 7.0 3. Glyceryl paraaminobenzoate 1.0 4. Ethyl urocanate 1.0 5. Magnesium salt of vitamin C phosphate ester 1.0 6. Cetyl alcohol 1.5 7. Glycerin monostearate 2.0 8. Polyoxyethylene (20) cetyl ether 3.0 9. Polyoxyethylene (20) soorbitan monooleate 2.0 10.1,3-butylene glycol 1.0 11. Glycerin 2.0 12. Akebi extract of Production Example 2 3.0 13. Aloe extract from Production Example 2 3.0 14. Swine placenta aqueous extract 3.0 3.0 15. Preservative (paraoxybenzoic acid ester) qs 16. Residual with purified water 100

(Formulation Example 3) Cosmetic oil weight% 1. Liquid paraffin 30.0 2. Squalane 20.0 3. Olive oil 20.0 4. Isopropyl palmitate 10.0 5. Grapefruit fruit or leaf hot water extract 3.0 6. Tochu leaf hot water extraction Product 3.0 7. Hippopotamus extract of Production Example 2 3.0 8. Garlic extract of Production Example 2 3.0 9. Olive oil 1.0 10. Shea butter 1.0 11. Butylhydroxyanisole 0.1 12. Vitamin E derivative 0.1 13. Preservative (benza chloride chloride) Ruconium) Appropriate amount 14. Fragrance (Tokimizu) Appropriate amount 15. Purified water 100 residue

(Formulation Example 4) Flexible lotion weight% 1. Glycerin 5.0 2.1,3-butylene glycol 5.0 3. Polyoxyethylene sorbitan monolaurate (20E.O) 1.0 4. Ethanol 15.0 5. Yuzu 30% ethanol extraction Liquid 1.0 6. Chickweed 30% ethanol extract 1.0 7. Grape stalk or leaf 30% ethanol extract 1.0 8. Pepper peel or fruit 30% ethanol extract 1.0 9. Kiwi fruit 50% ethanol extract 1.0 10. Antibacterial and antiseptic Agent (lactoferrin solution) qs 11. fragrance (western thin water) qs 12. purified water 100

(Formulation Example 5) Astringent lotion weight% 1. Sorvitol 2.0 2. POE (20) oleyl alcohol 1.0 3. Ethanol 15.0 5. Assembly 50% 1,3-butylene glycol extract 2.0 6. Yeast 50% 1 2,3-butylene glycol extract 2.0 7. Soapwort leaves 50% 1,3-butylene glycol extract 2.0 8. Gentian whole plant 50% ethanol extract 1.0 9. Sage whole plant 50% ethanol extract 1.0 10. Production Example 3 Panax ginseng extract 2.0 11. Narco lily extract of Production Example 3 2.0 12. Allantoin 0.2 13. Astringent (zinc sulfocarbonate) 0.2 14. Antibacterial and preservative (thiamine lauryl sulfate) qs 15. Perfume (lavender water ) Appropriate amount 16. Residual water to be 100

(Formulation Example 6) Two-layer lotion (liquid to liquid type) wt% 1. squalane 8.0 2. POE sorbitan tetraoleate 0.3 3. sorbit 1.0 4. ethanol 15.0 5. rhododendron rhizome or root bark 50 % Propylene glycol extract 2.0 6. Purple Root 50% propylene glycol extract 2.0 7. Perilla leaf 50% propylene glycol extract 2.0 8. Western lime tree flower or leaf 50% propylene glycol extract 1.0 9. Production Example 5 Hamasupha extract 2.0 10. Apricot extract of Preparation Example 2.0 2.0 11. Ascorbic acid 0.2 12. Astringent (calamine) 0.1 13. Preservative (phenoxyethanol) qs 14. Fragrance (lemon water) qs 15. Purified water 100 Residue

(Formulation Example 7) Carmine lotion (liquid to solid)% by weight 1. Glycerin 3.0 2.1,3-butylene glycol 5.0 3. Ethanol 15.0 4. Iron oxide (Bengara) 0.2 5. Zinc oxide 0.5 6. Kaolin 2.0 7. 50% Propylene glycol extract of Spiraea flower 2.0 8. 8. 50% Propylene glycol extract of Shakuyaku root 2.0 9. 50% Propylene glycol extract of Ussenior oil flower or leaf 2.0 10. 50% Propylene glycol extract of chamomile flower 2.0 11. Production example Taukogi extract of No. 5 2.0 12. Akebi extract of Production Example 5 2.0 13. Enzymatically decomposed extract of pork placenta 1.0 14. Camphor 0.2 15. Phenol 0.03 16. Preservative (photosensitizer 201 & 401) Appropriate amount 17. Fragrance (Bodaijusui) Appropriate amount 18.Purified water 100 residue

(Formulation Example 8) Pack% by weight 1. Polyvinyl alcohol 15.0 2. Sodium carboxymethyl cellulose 5.0 3. Propylene glycol 3.0 4. Ethanol 10.0 5. Aloe extract of Preparation Example 1.0 6. 6. Yuzu extract of Preparation Example 1 1.0 7. Kikyo 50% glycerin extract 1.0 8. T-shaped bud 50% glycerin extract 1.0 9. Satsuma mandarin peel 50% glycerin extract 1.0 10. Preservative (paraoxybenzoate) qs 11. Fragrance (rose water) qs 12.Remaining with purified water 100

(Formulation Example 9) Peel-off pack weight% 1. Glycerin 5.0 2. Propylene glycol 4.0 3. Polyvinyl alcohol 15.0 4. Ethanol 8.0 5. Polyoxyethylene glycol 1.0 6. Pantothenyl ethyl ether 1.0 7. Preparation example 3 Bulky extract 2.0 8. Dung beet extract of Production Example 3 2.0 9. Safflower whole plant 50% ethanol extract 2.0 10. Dutch jelly (parsley) leaf or stem 50% ethanol extract 2.0 11. Preservative (paraoxybenzoate) Proper amount 12.Perfume (Hiba water) Proper amount 13.Purified water 100 residue

(Formulation Example 10) Cold cream weight% 1. Salicone beeswax 11.0 2. Liquid paraffin 22.0 3. Lanolin 10.0 4. Olive oil 5.0 5. Chamomile oil 5.0 6. Palm oil 5.0 7. Borax 0.5 8. Hippo extract 2.0 (ethanol: 1,3-butylene glycol = 1: 1 extraction solvent) 9.Taukogi extract 2.0 (ethanol: 1,3-butylene glycol = 1: 1 extraction solvent) 10.Parietaria leaf extract 2.0 (ethanol: 1 , 3-butylene glycol = 1: 1 extraction solvent) 11. Birch bark extract 2.0 (ethanol: 1,3-butylene glycol = 1: 1 extraction solvent) 12. Liquid shea fat 1.0 13. Preservative (acrinol) 0.1 14 .Perfume (sage water) Appropriate amount 15. Residual water with 100 purified water

(Formulation Example 11) Emollient cream% by weight 1. Stearic acid 2.0 2. Stearyl alcohol 7.0 3. Reduced lanolin 2.0 4. Squalane 5.0 5. Octyldodecanol 6.0 6. Polyoxyethylene cetyl ether (25E.O.) 3.0 7. Lipophilic glyceryl monostearate 2.0 8. Propylene glycol 5.0 9. Yuzu extract of Preparation Example 3.0 10. Hot water extract 3.0 of dokudami 3.0 11. Tomato fruit hot water extract 3.0 12. Rosemary leaf or flower fever Water extract 2.0 13. Preservative (paraben) suitable amount 14. Fragrance (cinch water) proper amount 15. Purified water 100 residue

(Formulation Example 12) Face Wash Cream% by Weight 1. Myristic acid 25.0 2. Stearic acid 5.0 3. Tallow fatty acid 5.0 4. Propylene glycol 10.0 5. Potassium hydroxide 6.0 6. Coconut oil fatty acid diethanolamide 6.0 7. Almond extraction Liquid 2.0 (Ethanol: 1,3-butylene glycol = 1: 2 extraction solvent) 8. Hamajisha 20% 1,3-butylene glycol extract 2.0 9. Kawamurai 20% 1,3-butylene glycol extract 2.0 10. Loofah peel Or fruit powder 2.0 11. Bifidobacterium extract 1.0 12. Dipotassium glycyrrhetinate 1.0 13. Preservative (salicylic acid) 0.1 14. Perfume (sage water) qs 15. Purified water 100

(Formulation Example 13) Face Wash Cream% by Weight 1. Stearic acid 10.0 2. Palmitic acid 10.0 3. Myristic acid 12.0 4. Lauric acid 4.0 5. Oleyl alcohol 1.5 6. Lanolin derivative (EO adduct) 1.0 7. Glycerin 18.0 8. Potassium hydroxide 6.0 9. A: Akebi extract of Production Example 2 B: Aloe extract of Production Example 2 C: Apricot extract of Production Example 2 D: Hippo extract of Production Example 2 E: Production Example 2 Ginseng extract of Preparation Example 2 F: Dust extract of Preparation Example 2 G: Panax ginseng extract of Preparation Example 2 H: Takokogi extract of Preparation Example 2 I: Narco lily extract of Preparation Example 2 J: Extract of chickweed of Preparation Example 2 Material K: Extract of Anopheles japonica of Production Example 2 L: Extract of Bakryo of Production Example 2 M: Yuzu extract of Production Example 2 * Extract of any one of A to M 5.0 10. Royal jelly extract 1.0 (Ethanol: 1,3-butylene glycol = 1: 1 ) 11. Gurichirurirechin acid 1.0 12. Preservative (salicylic acid) 0.1 13. Perfume (mugwort water) balance to an appropriate amount 14. Purified water 100

(Formulation Example 14) Body soap weight% 1. Potassium laurate 15.0 2. Potassium myristate 5.0 3. Propylene glycol 5.0 4. 70% Himematsutake 1,3-butylene glycol extract 1.0 5. Garnish of Production Example 3 Extract 1.0 6. Wakame 70% 1,3-butylene glycol extract 0.5 7. Merilot flower or leaf 70% 1,3-butylene glycol extract 0.5 8. Amachiro leaf or stem 70% 1,3-butylene glycol extract 0.5 9. Polyethylene powder 0.5 10. Hydroxypropyl chitosan solution 0.5 11. Amino acid (glycine, glutamine, etc.) 0.5 12. Preservative (undecylenic acid, phenol) proper amount 13. pH adjuster proper amount 14. Flavor (lavender water) proper amount 15. Residue with 100 purified water

(Formulation Example 15) Sunscreen cosmetics (O / W type)% by weight 1. Oxybenzone 2.0 2. Octyl paramethoxycinnamate 5.0 3. Squalane 10.0 4. Vaseline 5.0 5. Stearyl alcohol 3.0 6. Stearic acid 3.0 7. Glyceryl monostearate 2.0 8. Polyethyl acrylate 1.0 9.1,3-butylene glycol 6.0 10. Disodium edetate 0.1 11. Triethanolamine 1.0 12. Titanium dioxide 5.0 13. Sanctin ginseng extract of Production Example 5 0.5 14. Cornflower 50% dipropylene glycol extract 0.5 15. Kakkon 50% dipropylene glycol extract 0.5 16. Preservative (paraben) qs 17. Fragrance (apple water) qs 18. Purified water 100

(Formulation Example 16) Sunscreen cosmetics (oil type)% by weight 1. Liquid paraffin 70.0 2. Ethyl paraaminobenzoate 1.0 3. Tetrahydroxybenzophenone 1.0 4. Cetyl octanoate 25.0 5. Narco lily 30% 1,3 -Butylene glycol extract 1.0 6. Roman chamomile flower 10% 1,3-butylene glycol extract 1.0 7. Burdock root 50% 1,3-butylene glycol extract 0.5 8. Teuchigurumi peel or leaf 30% 1,3-butylene Glycol extract 0.5 9. Adlay whole plant 50% 1,3-butylene glycol extract 0.5 10. Fencil fruit 30% 1,3-butylene glycol extract 2.0 11. Antioxidant (butylhydroxytoluene) qs 12. Fragrance ( Cornflower water) appropriate amount

(Formulation Example 17) Cream foundation (O / W type) weight% 1. stearic acid 4.0 2. glyceryl monostearate 3.0 3. cetanol 1.5 4. isopropyl myristate 7.0 5. liquid paraffin 10.0 6. salami beeswax 3.0 7. Triethanolamine 1.5 8. Glycerin 3.0 9. Bentonite 1.0 10. Titanium oxide 8.0 11.2,4-Dihydroxybenzophenone 8.0 12. Kaolin 3.0 13. Talc 3.0 14. Colored pigment (iron oxide yellow) 1.0 15. Hot water extraction Dry powder 0.2 16. Yuzu hot water extraction dry powder 0.2 17. Preservative (phenoxyethanol) suitable amount 18. Fragrance (rose water) proper amount 19. Purified water 100 residue

(Formulation Example 18) Shampoo wt% 1. Triethanolamine lauryl sulfate 5.0 2. Sodium polyoxyethylene lauryl ether sulfate 12.0 3.1,3-butylene glycol 4.0 4. Diethanolamide laurate 2.0 5. Disodium edetate 0.1 6. Apricot 20% 2,3-butylene glycol extract 2.0 7. Birch hot water extract 2.0 8. Hamazha 30% 1,4-butylene glycol extract 2.0 9. Tokina 30% 1,4-butylene glycol extract Liquid 1.0 10. Hydroxypropyl chitosan solution 2.0 11. Mucopolysaccharide solution 1.0 12. Antibacterial and preservative (photosensitizer No. 101) qs 13. pH adjuster qs 14. Fragrance (sandalwood water) qs 15. Purified water 100 Residue

(Formulation Example 19) Rinse weight% 1. Stearyltrimethylammonium chloride 2.0 2. Cetostearyl alcohol 2.0 3. Polyoxyethylene lanolin ether 3.0 4. Propylene glycol 5.0 5. Akebi 50% 1,2-butylene glycol extract 1.0 6. Assemble leaf or stem 50% 1,2-butylene glycol extract 1.0 7. Eustoma flower 50% 1,2-butylene glycol extract 1.0 8. Coltsfoot flower or leaf 50% 1,3-butylene glycol extract 1.0 9. Hydroxyethyl chitosan solution 1.0 10. Trehalose solution 1.0 11. Hydrolyzed silk solution 1.0 12. Antibacterial and preservative (benzalkonium chloride) qs 13. perfume (lavender water) qs 14. Purified water 100 Residue

(Formulation Example 20) Rinse weight% 1. Stearyltrimethylammonium chloride 2.0 2. Cetostearyl alcohol 2.0 3. Polyoxyethylene lanolin ether 3.0 4. Propylene glycol 5.0 5. Ethylene glycol 3.0 6. Yuzu extraction of Production Example 1 Product 1.0 7. Olive seed 50% 1,3-butylene glycol extract 1.0 8. Loquat leaf 30% ethanol extract 1.0 9. Trehalose solution 1.0 10. Hydrolyzed keratin solution 1.0 11. Antibacterial and preservative (benza chloride chloride) Ruconium) Appropriate amount 12.Fragrance (chamois water) Appropriate amount 13.Remaining amount of purified water 100

(Formulation Example 21) Hair liquid% by weight 1. Ethanol 29.0 2. Polyoxypropylene butyl ether phosphoric acid 10.0 3. Polyoxypropylene monobutyl ether 5.0 4. Triethanolamine 1.0 5. Sanctin ginseng extract of Production Example 1 2.0 6. Hops spikes 50% ethanol extract 1.0 7. Melissa whole plant 50% ethanol extract 1.0 8. Carpronium chloride 0.3 9. Hinokitiol 0.5 10. Keratin decomposition solution 1.0 11. Antibacterial and preservative (paraben, benzalco chloride) Ni) Suitable amount 12. Fragrance (Rosehip water) Appropriate amount 13. Residual water with 100 purified water

(Formulation Example 22) Hair liquid% by weight 1. Ethanol 29.0 2. Polyoxypropylene butyl ether phosphoric acid 10.0 3. Polyoxypropylene monobutyl ether 5.0 4. Triethanolamine 1.0 5. Trimethylene glycol 5.0 6. Production Example 2 Chickweed extract 1.0 7. Lemon fruit 50% 1,3-butylene glycol extract 0.5 8. Apple fruit 30% ethanol extract 1.0 9. Azulene 1.0 10. Antibacterial and preservative (paraben, benzalkonium chloride) qs 11 .Perfume (jasmine water) Appropriate amount 12.Purified water 100 residue

(Formulation Example 23) Hair tonic weight% 1. Ethanol 40.0 2. Ethyl oleate 1.0 3. Polyoxyethylene (40) hydrogenated castor oil 2.0 4. A: Akebi extract of Production Example 2 B: Production Example 2 C: apricot extract of Production Example 2 D: Hippo extract of Production Example 2 E: Kikyo extract of Production Example 2 F: Dust extract of Production Example 2 G: Ginseng extract of Production Example 2 Product H: Taukogi extract of Preparation Example 2 I: Narco Lily extract of Preparation Example 2 J: Chlorophyll extract of Preparation Example K: Kamazusha extract of Preparation Example 2 L: Bulky extract of Preparation Example M: Preparation Example Yuzu extract of No. 2 * Extract of any one of A to M 5.0 5. Comfrey leaf or stem 50% ethanol extract 3.0 6. Lettuce leaf 50% ethanol extract 3.0 7. Preservative (phenoxyethanol) 0.18 .Remaining amount of purified water 100

(Formulation Example 24) Hair tonic weight% 1. l-menthol 0.2 2. ethanol 32.5 3. polyoxyethylene hydrogenated castor oil 0.5 4. propylene glycol 5.0 5. diphenhydramine hydrochloride 0.3 6. 2.0 7. Hot water extract of pepper fruit 1.0 8. Ethanol extract of rhizome or root bark 50% ethanol extract 1.0 9. Rhizoma rhizome or root bark 50% ethanol extract 1.0 10. Rhizoma rhizome or root bark 50% ethanol extract 1.0 11. Carboxymethyl chitin solution 1.0 12. Vitamin E derivative 0.5 13. Antibacterial and preservative (paraben) 0.1 14. Appropriate amount of fragrance (sage water) 15. Purified water 100 residue

(Formulation Example 25) Hair restorer / hair restorer (% by weight) 1. Ethanol 60.0 2. 50% glycerin extract of Akabi 5.0 3. Extract of propylene glycol 50% from whole plant of Periwinkle 2.0 4. Vitamin E derivative 0.5 5. Pepper tincture 0.5 6. Resorcinol 0.5 7. Dipotassium glycyrrhizinate 0.5 8. Carboxymethyl chitin solution 0.5 9. Porcine hematin solution 0.5 10. Porcine mucin solution 0.5 11. Amino acids (glycine, glutamine, etc.) 0.5 12. Antibacterial and preservative (paraben) 0.1 13 .Perfume (rosemary water) Appropriate amount 14. Residual water to make purified water 100

(Formulation Example 26) Hair restorer / hair restorer weight% 1. Ethanol 60.0 2. Kikyo extract of Production Example 2 3. Ethanol extract of whole plant 60% 1.0 4. Ethanol extract of button rhizome or root bark 60% ethanol 1.0 5. Cantaris tincture 0.5 6. Pantothenic acid derivative 0.5 7. Glycyrrhizic acid 0.5 8. Resorcin 0.5 0.5 Salicylic acid 0.5 10. Hydroxyethyl chitosan solution 0.5 11. Elastin hydrolyzate 0.5 12. Antibacterial and preservative (paraben) 0.1 13. Suitable amount of fragrance (lavender water) 14. Residual amount of purified water 100

(Formulation Example 27) Granule bath agent weight% 1. Sodium bicarbonate 58.0 2. Anhydrous sodium sulfate 30.0 3. Borax 2.0 4. Birch extract dry powder 5.0 of Production Example 1 5. Sengyu hot water extract dry powder 8.0 6. Jujube whole plant hot water extraction dry powder 2.0 7. Pigment (Gunjo green) suitable amount

(Formulation Example 28) Granule bath agent weight% 1. Sodium bicarbonate 58.0 2. Anhydrous sodium sulfate 30.0 3. Borax 4.0 4. Dried powder of turmeric extract of Production Example 1 3.0 5. Dried powder of black tea hot water extraction 1.0 6. Drying powder extracted with hot water of Artemisia serrata 1.0 7. Dry powder extracted with 50% ethanol from Satsuma mandarin orange 8. Dry powder extracted with iris leaf or root 70% ethanol 1.0 9. Apple juice powder 1.0 10. Pigment (Gunjo, chromium hydroxide) 11.Perfume (Roman chamomile water)

(Formulation Example 29) Coating protective agent A gauze or liniment cloth is impregnated with a prescription solution prepared by mixing an appropriate amount of a hot water extract of fennel and a hot water extract of Narco lily, an antibiotic, an anti-inflammatory agent, etc., and attached to the wound. I do. Alternatively, the Kikyo hot water extract and the Narco lily hot water extract may be directly sprayed locally and covered with gauze or the like.

(Formulation Example 30) Oral freshener weight% 1. Ethanol 20.0 2. Glycerin 15.0 3. Polyoxyethylene hydrogenated castor oil 1.0 4. Saccharin 0.2 5. Chlorohexidine 0.01 6. Yuzu extract dry powder of Production Example 1 0.1 7. Dry powder of Kikyo extract in Production Example 1 0.1 8. Appropriate amount of pigment (Gunjo green) 9. Residue with purified water 100

(Formulation Example 31) Dishwashing detergent weight% 1. Alkyl (C12) glucoside 20.0 2. Polyoxyethylene (3) Na dodecyl ether sulfate 10.0 3. Glycerin 2.0 4. Ethanol 5.0 5. Sansiti of Production Example 1 Carrot extract dry powder 3.0 6. Soybean hot water extract dry powder 3.0 7. Purified water 100 residue

(Formulation Example 32) Mentsuyu (Weight%) 1. Soy sauce 80.0 2. Black vinegar 2.0 3. Glucose 13.0 4. Sodium glutamate 2.0 5. Dry powder of Panax ginseng extract of Production Example 1 1.5 6. Yuzu of Production Example 1 Extract dry powder 1.5

(Formulation Example 33) Udon or buckwheat wt% 1. Flour or buckwheat flour 93.0 2. Salt 1.0 3. Dry powder of akebi extract of Preparation Example 2.0 4. Dry powder of aloe extract of Preparation Example 2.0 5. Chamomile whole plant hot water extract dry powder 2.0

(Formulation Example 34) Beverage wt% 1. Glucose liquid sugar 30.0 2. Grapefruit juice 45.0 3. Dry powder of Pacific seaweed extract 5.0 from Production Example 1 4. Mucopolysaccharide solution 6.0 5. Strawberry juice 5.0 6. Iyokan juice 5.0 7.Fructose 4.0 8.Flavor suitable amount 9.Sour seasoning appropriate amount

(Formulation Example 35) Bread wt% 1. Wheat flour 80.0 2. Salt 1.0 3. Glucose 7.0 4. Dry powder of the groundworm extract of Production Example 1 4.0 5. Apple fruit water extract 4.0 6. Carboxymethyl chitin solution 2.0 7. Vitamin E 1.0 8. Heme iron 1.0

(Formulation Example 36) Sausage wt% 1. Ground meat 80.0 2. Chicken eggs 10.0 3. Spices 2.0 4. Seasonings 2.0 5. Dry powder of the Japanese fennel extract of Production Example 1 2.0 6. Pepper extract 4.0

(Formulation Example 37) Gum weight% 1. Menthol micron 30.0 2. Grapefruit flavor 50.0 3. Lemon flavor 14.0 4. Dry powder of hippo extract of Production Example 2.0 5. Dry powder of garnish extract of Production Example 1 2.0 6. Tannin 2.0

(Formulation Example 38) Miso soup wt% 1. Tofu 30.0 2. Deep fried 5.0 3. Carrot 5.0 4. Burdock 5.0 5. Chinese cabbage 5.0 6. Red miso 20.0 7. Dry powder of Narco lily extract of Production Example 1 2.0 8. Okra fruit hot water extract powder 1.0 9.

(Formulation Example 39) Cookie weight% 1. Milk 62.0 2. Whole egg 14.0 3. Sugar 12.5 4. Constarch 5.0 5. Salt 0.5 6. Dry powder of the turmeric extract of Production Example 1 2.0 7. Perfume

(Test 5) Use Effect Test The effect when the cosmetic composition of the present invention was actually used was examined. The use test was conducted by a panel of 10 persons aged 30 to 50 years old who suffered from dry skin or shiny / skin-free skin. This was done by applying over a period of months.
As a control, a preparation prepared by removing a plant extract of the present invention from the emulsion in the same manner was used. The evaluation was performed according to the following criteria. The results are shown in Table 2 and the numbers in the table represent the number of persons. No one complained of abnormal skin during the use period.

"Effect of improving skin feel" Efficacy: Dry skin and skin gloss / tension increased, and skin was improved. Somewhat effective: Dry skin and skin gloss and tension are slightly increased,
Skin is improved. Ineffective: No change from before use.

<Table 2>

(Test results) As shown in Table 2, the plant extracts of the present invention, Akebi, Aloe, Apricot, Hippo, Kikyo, Gomushi, Sanshin ginseng, Taukogi, Narco lily, Hakobe, Hama-sha, Bukuryo and Yuzu were blended. It was confirmed that the emulsion significantly gave gloss and tension to the skin and improved dry skin.

(Test 6) Use Effect Test The effect when the food of the present invention was actually used was examined. The use test was conducted with 10 persons each of 30 to 50 years old who are suffering from dry skin or shiny / skin-free skin as panelists.
g) for 3 months. A control prepared by removing the plant extracts of the present invention from bread in the same manner was used as a control. The evaluation was performed according to the following criteria. The results are as shown in Table 3 and the numerical values in the table represent the number of persons. No one complained of abnormal skin during the use period.

"Effect of improving skin feel" Efficacy: Dry skin and skin gloss / tension increased, and skin was improved. Slightly effective: Dry skin and skin gloss / tension increased slightly, and skin was improved. Ineffective: No change from before use.

[0152]

(Test Results) As shown in Table 3, the plant extracts of the present invention, Akebi, Aloe, Apricot, Hippo, Kikyo, Gomushi, Sanshin ginseng, Taukogi, Narco lily, Hakobe, Hamasha, Bukuryo and Yuzu were blended. It was confirmed that the bread significantly gave gloss and tension to the skin and improved dry skin.

[0154]

According to the present invention, the akebi, aloe, apricot, hippo, kikyo, goshi, sanshin ginseng, taukogi,
To confirm that at least one plant extract selected from narco lily, chickweed, hamadashia, boukuro, and yuzu has a pentosidine production inhibitory effect, and to apply it as a Maillard reaction inhibitor. Furthermore, it is safe to use internally or externally for humans or animals. Therefore, it can be usefully used as a Maillard reaction inhibitor, and can be used in various forms of pharmaceuticals (medicines, quasi-drugs, cosmetics, foods)
It can be applied to In addition, we give skin gloss and tension,
It is effective for preventing and improving dry skin, and also for preventing and improving various diseases related to inhibition of Maillard reaction, such as reduced skin elasticity such as wrinkles and sagging of the skin, aging of the skin, and complications derived from diabetes. Available.

Continued on the front page (51) Int.Cl. ⁷ Identification symbol FI Theme coat II (reference) A61K 35/78 A61K 35/78 T 4B042 V 4B046 A23L 1/272 A23L 1/272 4B047 1/30 1/30 B 4C083 A61K 7/00 A61K 7/00 K 4C088 7/48 7/48 A61P 43/00 A61P 43/00 111 111 // A21D 2/36 A21D 2/36 13/00 13/00 13/08 13/08 A23G 3 / 30 A23G 3/30 A23L 1/16 A23L 1/16 A F 1/22 1/22 D 1/317 1/317 A 1/39 1/39 2/52 2/00 F (72) Inventor Nobuyasu Matsuura Toyama 5180 Kurokawa, Kosugi-cho, Imizu-gun, Japan F-term (Reference) at the University of Toyama Pref. 4B046 LA02 LA04 LC06 LG25 LG32 LG33 4B047 LB09 LG37 LG38 LG65 4C083 AA032 AA082 AA111 AA112 AA122 AB032 AB152 AB212 AB232 AB242 AB312 AB352 AB432 AB442 AC022 AC072 AC102 AC122 AC132 AC182 AC212 AC242 AC302 AC312 AC342 AC422 AC432 AC442 AC472 AC532 AC542 AC552 AC582 AC642 AC692 AC782 AC852 AC862 AD022 AD092 AD112 AD272 AD322 AD412 AD532 AD642 AD662 CC04 CC05 CC33 CC33 CC33 CC41 DD16 DD27 DD33 EE12 EE13 EE17 4C088 AA04 AA08 AB12 AB18 AB25 AB26 AB52 AB62 AB65 AB85 AB86 BA08 ZA89 ZB21 ZC52

Claims (4)

[Claims] 1. A plant extract containing at least one plant extract selected from the group consisting of akebi, aloe, apricot, hippopotamus, kikyo, goshi, ginseng, ginseng, turmeric, narco lily, chickweed, hamazsha, bukuro, and yuzu. Maillard reaction inhibitor. 2. The Maillard reaction inhibitor according to claim 1, which has a pentosidine production inhibitory action. 3. A cosmetic composition comprising the Maillard reaction inhibitor according to claim 1 or 2. 4. A food or drink comprising the Maillard reaction inhibitor according to claim 1 or 2.