JP2003095913A - Cosmetic composition or food and drink - Google Patents

Abstract

PROBLEM TO BE SOLVED: To obtain a new and safe humectant, skin aging preventing agent, antiinflammation agent, cosmetic composition and food or drink. SOLUTION: The humectant, skin aging preventing agent, antiinflammation agent, a cosmetic composition, or food and drink containing the above agents contains one or more decomposed proteins selected from silk protein, keratin protein and collagen protein. The present invention further provides a cosmetic composition or food and drink containing the extract of one or more plants selected from Plectranthus rugosus, Hypericum erectum, salvia, lime tree and fruit of Momordica grosvenori. The composition has humectant action, skin aging preventing action and antiinflammation action, keeps the moisture of the skin, improves the dry skin, imparts the skin with luster and springiness and improves the wrinkling and sagging of the skin. It is also useful for the prevention and amelioration of the UV-induced inflammation and resulting inflammatory skin diseases (e.g. roughened skin, eczema and itchiness) and is applicable to any preparation (pharmaceuticals, quasi-drugs, cosmetics and foods).

Description

Detailed Description of the Invention

[0001]

TECHNICAL FIELD The present invention comprises a moisturizer containing one or more proteolytic products selected from silk protein, keratin protein and collagen protein, a skin anti-aging agent, an anti-inflammatory agent and the like. Cosmetic composition or food and drink.
In addition, by containing one or more kinds of plant extracts selected from Triturium, Hypericum, Salvia, Bodaiju, and Rakanka, a moisturizing action, a skin anti-aging action, and an anti-inflammatory action exert a synergistic effect. The present invention relates to application to a moisturizing agent, a skin anti-aging agent, an anti-inflammatory agent, a cosmetic composition or a food or drink.

[0002]

2. Description of the Related Art Human skin is covered by a stratum corneum, which is a thin biological defense film, and it is possible to live in a dry atmosphere without losing water. Because there exists. The stratum corneum is thin and supple, and keeps the water in the body from being lost, and regulates the skin in a normal state.

However, trauma to the skin (burns, inflammation, and various other factors), so-called epidermis-like injury, is in a state in which a functionally incomplete horny layer is formed. The skin is hard and covered with an inelastic stratum corneum, and the stratum corneum is cracked, exfoliates as large lumps in places, forms clinical scales, and is much larger than normal skin. Evaporation of water will occur.

That is, the elasticity / extendability required for the stratum corneum
One of the causes of loss of strength is decreased skin moisture
Are involved. The functionally defective stratum corneum does not have enough water binding (retention) to keep the stratum corneum itself flexible, which in turn allows the passage and loss of large amounts of moisture through the skin. Generally, the stratum corneum has a dry weight of 10
When the water content is reduced to less than 100%, the suppleness and softness of the skin that had been maintained until then is lost, and the skin becomes hard and brittle.
It can be said that the amount of water in the stratum corneum of the skin is very important, as it results in dry, dry, or moisturized skin (skin).

Further, typical changes in the aging of human skin are wrinkles, tarmi and kusumi, which are one of the major problems of skin for the elderly and women. However, there are currently few effective treatments for the prevention of skin aging (particularly wrinkles, tarmi, and dullness), and various studies on aging have been conducted in the aging society. It is coming.

At present, it is considered that the formation of wrinkles and tarmi on human skin is caused by the decrease in elasticity of the skin. However, specific histological phenomena include changes in extracellular matrix components such as collagen, elastin, and glycosaminoglycans in the dermis.

[0007] In particular, collagen, which is the main component of the matrix, is decreased by physiological aging and long-term exposure to ultraviolet light, and the decrease in skin elasticity caused during the formation of wrinkles and tarmi is caused by (production and secretion from dermal fibroblasts. It is considered that MMP-related enzymes are involved in the change in three-dimensional structure due to collagen or elastin damage, that is, the modification of collagen or elastin is said to be important for skin aging prevention (skin tension and elasticity). ing.

Also, the ultraviolet rays of the sun rays are
It is useful in health and hygiene such as vitamin D synthesis, sterilization and disinfection, but it also has harmful effects such as sunburn, suntan, skin aging and skin cancer induction.

[0009] The sunlight and ultraviolet rays are divided into three regions, a UV-C region of 290 nm or less, a UV-B region of 290-320 nm, and a UV-A region of 320-400 nm, depending on the biological action. Cage, U
The VC region is an ultraviolet ray that has a strong effect on organisms and is highly carcinogenic, but it is said that it will not reach the ground because it is mostly absorbed by the ozone layer in the stratosphere, but in recent years, the decrease of the ozone layer has become a problem, There is concern about an increase in skin cancer. UV rays in the UV-B and A areas are also sunburn (acute inflammation)
It has been reported to promote aging, suntan (pigmentation), skin aging, and the development of skin cancer, but when UV rays are applied to the skin, UV-B penetrates the stratum corneum and the epidermis, and about 3- Erythema appears after 6 hours and peaks after about 24 hours. And
The erythema gradually turned to blackening in 4 to 15 days, which was attributed to the increased melanin production due to activation of melanocytes by the inflammatory reaction by UV-B, and was further damaged. It is said that keratinization progresses in the epidermal tissue, resulting in rough skin, stains, and freckles accompanying a decrease in the water content of the stratum corneum.

UV-A is said to reach the dermis layer, cause immediate blackening, and disappear in a short period of time. It is considered that this is because existing melanin is temporarily oxidized to become black and continuously. When it is bathed, it causes a delayed blackening, and although erythema does not appear, it promotes the activation of melanocytes and the degree of blackening becomes stronger. Further, it is also reported that the high skin permeability causes damage to dermal tissues (protein components such as collagen and elastin), resulting in reduced elasticity of skin, imparted skin inflammation, rough skin, wrinkles, and tarmi. In addition, this ultraviolet ray may cause damage to the DNA, which is the body of the gene, and therefore these ultraviolet rays (UV
-C, UV-B, UV-A) protection is also important.

[0011]

SUMMARY OF THE INVENTION Therefore, the present invention is said to be the cause of skin aging, which is a decrease in the water retention function of the skin, a decrease in the elasticity / tension / gloss of the skin, the formation of wrinkles and tarmi, or inflammation caused by ultraviolet rays. It is an object of the present invention to provide a material effective against inflammatory skin diseases (eg, rough skin, eczema, pruritus) associated therewith.

[0012]

In view of such circumstances, the present inventors have made useful proteins or plant components the theme of development, and as a result, have a moisturizing action on various protein degradation products of silk proteins, keratin proteins, and collagen proteins. , Has anti-aging and anti-inflammatory effects on skin, and further contains one or more kinds of plant extracts selected from nematodes, Hypericum perforatum, Salvia, Bodaiju and Rakanka. I found out. Therefore, the present invention has been completed by providing a safe moisturizer, skin anti-aging agent, anti-inflammatory agent, cosmetic composition or food and drink.

[0013]

BEST MODE FOR CARRYING OUT THE INVENTION The raw material of "silk protein" used in the present invention may be silk fibroin protein or silk sericin protein prepared from silk. Alternatively, it can be produced by decomposition by a bioreactor method. For example, it can be manufactured as follows.

First, the silk is heated to 80 ° C. or higher and sterilized by heating,
This is dissolved in a high-concentration salt solution of lithium bromide, magnesium nitrate, calcium chloride, etc. by heating, and then desalted by dialysis, reverse osmosis, etc., and then a proteolytic enzyme is allowed to act on it. As the protease, trypsin, chymotrypsin, papain, pepsin, rennin, pancreatin, elastase, carboxypeptidase, aminopeptidase, dipeptidase, alcalase and the like can be used, for example, trypsin to 40 parts of silk 1 37 ° C in parts
Operate at pH 7.0. At that time, preferably 24
Aseptically decomposed over a period of time, then heated to 80 ° C. or higher to inactivate the enzyme, and then centrifuged to remove the precipitate, whereby a decomposed product derived from silk protein can be obtained. This is made into powder by spray drying, freeze drying, or the like.

The "keratin protein" used in the present invention
The raw material of can be used a protein prepared from feathers, wool, etc., as a production method, alkali decomposition, oxidative decomposition with an inorganic acid or organic acid, reductive decomposition with a reducing agent and decomposition by a direct or bioreactor method with an enzyme. Although it can be manufactured, for example, it can be manufactured as follows.

Hydrochloric acid was added to the feathers and decomposed for 15 hours at 100 ° C., neutralized with sodium hydroxide, desalted, spray-dried and powdered.

As the raw material of the "collagen protein" used in the present invention, a collagen protein prepared from bones, skins, muscles, etc. of animals such as pigs, cows, chickens and fish can be used. It can be prepared by fermentation with alkali, yeast and decomposition by enzyme directly or by bioreactor method. For example, it can be manufactured as follows.

After washing the porcine skin tissue with water, purified water is added to the product to decompose it with an enzyme, which is then purified and powdered by spray drying.

In addition, the term "green nematode" (also known as "enmeisou") used in the present invention means Labiatae, genus Yamahaka.
(Rabdosia) plants: Hiki-koshi "Rabdosia japonicus
(Burm.f.) Hara (= Isodon japonicus Hara) '' or flower of the black squirrel (Isodon trichocarpus Kubo), spike, pericarp, fruit, stem, leaf, branch, branch, stem, bark, rhizome,
Use root bark, roots, seeds or whole plants.

Further, "Hypericum (also known as younger brother cut grass)" used in the present invention means a plant of the family Hypericum (Guttiferae): Hypericum: Hypericum.
cum erectum Thunb.), Hypericum perforatum (Hypericu
m perforatum L.), Hypericum perforatum (Hypericum p.
erforatum L.var angustifoliom DC) flower, spike, pericarp, fruit, stem, leaf, branch, branch, stem, bark, rhizome, root bark,
Use roots, seeds or whole plants.

The "salvia (alias:
`` Sage) '' means Labiatae and Salvi
Plants of a): Salvia (Salvia officinalis L.) flowers, spikes, pericarps, fruits, stems, leaves, branches, branches, stems, bark, rhizomes,
Use root bark, roots, seeds or whole plants.

The term "bodijju (also known as bodhi tree)" used in the present invention means a plant belonging to the family Tiliaceae and genus Tilia: Tilia platyphyllos.
Scop.), Fuyudaiju (Tilia cordata Mill.), Flowers of Tilia europaea L.) or other closely related plants, spikes, pericarp, fruits, stems, leaves, branches, branches, stems, bark, rhizomes, Use root bark, roots, seeds or whole plants.

In addition, "Rakanka (also known as:
(Rakanka) ”means Cucurbitaceae,
(Momordica) plants: Momordica Grossvenoli "M
omordica grosvenorii Swingle. (= Siraitia grosvenor
ii (Swingle) C. Jeffrey) "flowers, spikes, peels, fruits,
Stems, leaves, branches, branches and leaves, stems, bark, rhizomes, root bark, roots, seeds or whole plants are used.

[0024] The extracts of Trillium perforatum, Hypericum perforatum, Salvia, Bodaiju, and Rakanka used in the present invention are:
Various parts of each plant (flower, spike, pericarp, fruit, stem,
(Leaves, branches, branches, stems, bark, rhizomes, root bark, roots, seeds or whole plants) as they are or after crushing and squeezing. Alternatively, it is extracted with a solvent as it is or after pulverization.

The extraction solvent for the above-mentioned various plant extracts may be selected in consideration of the purpose of use, the type of product to be provided, the processing to be performed later, etc.
Water, lower alcohols such as methanol, ethanol, propyl alcohol, isopropyl alcohol, butanol, isobutanol, etc. or hydrous lower alcohols, propylene glycol, 1,3-butylene glycol, polyhydric alcohols such as glycerin, or hydrous polyhydric alcohols, acetone, acetic acid It is desirable to use one or a mixture of two or more selected from various organic solvents such as ethyl. However,
When the content of the organic solvent is not preferable depending on the purpose of use, water alone may be used, or ethanol that is easy to remove after extraction may be used and used alone or in any mixture with water. You can use the extracted one.
Furthermore, it can be used in a state where each solvent extract is combined.

In addition to the hydrolytic extraction of the above-mentioned various plants by enzymatic decomposition, those hydrolyzed by acid / alkali can also be used.

The manufacturing method is not particularly limited, but it is usually within the range of the boiling point of the solvent at room temperature and atmospheric pressure, and after extraction, filtration or ion exchange resin is used for adsorption / adsorption.
It may be decolorized and purified to form a solution, paste, gel or powder. In many cases, it can be used as it is, but if necessary, further purification treatment such as deodorization and decolorization may be added within a range that does not affect the effect, and as a purification treatment means such as deodorization and decolorization. It suffices to use an activated carbon column or the like, and any ordinary means generally applied depending on the extraction substance may be arbitrarily selected. It is also possible to add an organic solvent such as ethanol, propylene glycol, 1,3-butylene glycol, phenoxyethanol or the like, or an arbitrary mixture thereof to the extract after extraction. The obtained extract can be used as it is, but can also be used as a paste or powder by concentrating and drying.

The various proteolytic products of the silk protein, keratin protein and collagen protein of the present invention are used as they are as moisturizers,
Although it can be contained in a skin anti-aging agent, an anti-inflammatory agent, a cosmetic composition or a food or drink, the content thereof is not particularly limited, and a moisturizing agent, a skin anti-aging agent, an anti-inflammatory agent, a cosmetic composition or Slightly different depending on the type of dosage form of food and drink, quality and expected degree of action, usually 0.001 mass% or more (hereinafter,
%) Is preferably 0.2 to 20%. Further, in the case of a bath agent, the formulation may be taken into consideration so that it is poured into 200 to 300 L of bath water so as to have the same concentration.

[0029] Similarly, various plant extracts of Triticum perforatum, Hypericum perforatum, Salvia, Bodaiju, and Rakanka of the present invention are also moisturizing agents, skin anti-aging agents, anti-inflammatory agents,
It can be contained in a cosmetic composition or a food or drink, and the content thereof is not particularly specified, and a moisturizer, a skin anti-aging agent, an anti-inflammatory agent, a type of dosage form of a cosmetic composition or a food or drink,
It varies slightly depending on the quality and the expected degree of action, and is usually 0.01% or more, preferably 3 to 50%. Further, in the case of a bath agent, the formulation may be taken into consideration so that it is poured into 200 to 300 L of bath water so as to have the same concentration.

Further, the moisturizing agent, skin anti-aging agent, anti-inflammatory agent, cosmetic composition or food / beverage product of the present invention may have any dosage form / form, including capsules, powders, granules, solids, liquids, gels and bubbles. , Emulsion, cream, ointment, sheet and the like can be mixed and used.

The fields of use thereof are, for example, all kinds of internal and external preparations (including preparations used for animals) in general, and specifically, ampoules, capsules, pills, tablets, powders, granules. , Solids, liquids, gels, bubbles, emulsions, sheets, mists, sprays, etc. 1) pharmaceuticals, 2) quasi drugs, 3) topical or systemic skin cosmetics ( For example, lotions, emulsions, creams, ointments, lotions, oils, basic cosmetics such as packs, facial cleansers and skin cleansers, massage agents, cleansing agents,
Makeup cosmetics such as hair remover, depilatory, shaving treatment, after shave lotion, pre-show lotion, shaving cream, foundation, lipstick, blusher, eye shadow, eyeliner, mascara, perfume, nail polish, beauty Nail enamel, beauty nail enamel remover, poultice, plaster, tape, sheet, patch, aerosol, etc.), 4) Medicinal and / or cosmetic preparations applied to the scalp and hair (eg shampoo) Agent, rinse agent,
Hair treatment agent, pre-hair treatment agent, permanent liquid, hair dye, hair styling agent, hair styling agent, hair growth agent, hair nourishing agent, patch agent, plaster agent, tape agent, sheet agent, patch agent, aerosol agent, etc.), 5) bath Bath agents to be used by pouring in hot water, 6) Others, armpit deodorant and deodorant,
Examples include deodorants, antiperspirants, hygiene products, sanitary cotton, wet tissues, toothpaste, mouthwash, mouthwash, and 7) food and drink.

Further, as foods and beverages, oral composition (gum, candy, etc.), processed fish paste products such as kamaboko and chikuwa, livestock products such as sausage and ham, western confectionery, Japanese confectionery, raw noodles, Chinese noodles, boiled noodles. , Noodles such as buckwheat, sauce, soy sauce, sauce, sugar, honey, powdered candy,
Seasonings such as starch syrup, spices such as curry powder, mustard powder, pepper powder, jam, marmalade, chocolate spread, pickles, greens, sprinkles, or processed vegetables and fruits such as canned and bottled vegetables and fruits, Dairy products such as cheese, butter, yogurt, miso soup, soup, fruit juice,
It can be used for general food and drink such as vegetable juice, whey beverage, soft drink, beverage such as alcoholic beverage, health food and the like.

The moisturizing agent, skin anti-aging agent, anti-inflammatory agent, cosmetic composition or food and drink of the present invention may be added, in addition to the above-mentioned essential components, within a range that does not impair the effects of the present invention, if necessary.
The components and additives exemplified below can be arbitrarily selected and used in combination, and the content in the preparation is not particularly limited, but is usually 0.0001 to 50%.

(1) Various oils and fats Avocado oil, almond oil, fennel oil, sesame oil,
Olive oil, orange oil, orange lafa oil, sesame oil, cocoa butter, chamomile oil, carrot oil, cucumber oil, tallow fatty acid, kukui nut oil, safflower oil, shea butter, liquid shea butter, soybean oil, camellia oil, corn oil, rapeseed Oil, Persic oil, Castor oil, Cottonseed oil, Peanut oil, Turtle oil, Mink oil, Egg yolk oil, Palm oil, Palm kernel oil, Owl, Palm oil, Beef tallow, Lard, Squalene,
Squalane, pristane or hydrogenated products of these oils (hardened oil, etc.), etc.

(2) Waxes Beeswax, carnauba wax, whale wax, lanolin, liquid lanolin, reduced lanolin, hard lanolin, candelilla wax,
Montan wax, shellac wax, rice wax, etc.

(3) Mineral oil Liquid paraffin, petrolatum, paraffin, ozokeride, ceresin, microcrystalline wax and the like.

(4) Fatty acids Lauric acid, myristic acid, palmitic acid, stearic acid, behenic acid, oleic acid, linoleic acid, linolenic acid,
Docosahexaenoic acid, eicosapentaenoic acid, 12-hydroxystearic acid, undecylenic acid, tall oil, natural fatty acids such as lanolin fatty acid, isononanoic acid, caproic acid, 2-ethylbutanoic acid, isopentanoic acid, 2-methylpentanoic acid, 2-ethylhexane Acids, synthetic fatty acids such as isopentanoic acid.

(5) Alcohols ethanol, isopropyl alcohol, lauryl alcohol,
Natural alcohols such as cetanol, stearyl alcohol, oleyl alcohol, lanolin alcohol, cholesterol, phytosterol, phenoxyethanol, 2-
Hexyldecanol, isostearyl alcohol, 2-octyldodecanol and other synthetic alcohols.

(6) Polyhydric alcohols ethylene oxide, ethylene glycol, diethylene glycol, triethylene glycol, ethylene glycol monoethyl ether, ethylene glycol monobutyl ether, diethylene glycol monomethyl ether, diethylene glycol monoethyl ether, polyethylene glycol, propylene oxide, propylene glycol , Polypropylene glycol, 1,3-butylene glycol, pentyl glycol, glycerin, pentaerythritol, threitol, arabitol, xylitol, ribitol, galactitol, sorbitol, mannitol, lactitol, maltitol and the like.

(7) Esters Isopropyl myristate, isopropyl palmitate, butyl stearate, hexyl laurate, myristyl myristate, oleyl oleate, decyl oleate, octyldodecyl myristate, hexyldecyl dimethyloctanoate, cetyl lactate, Myristyl lactate, diethyl phthalate, dibutyl phthalate, lanolin acetate, ethylene glycol monostearate, propylene glycol monostearate, propylene glycol dioleate, etc.

(8) Metal soaps Aluminum stearate, magnesium stearate, zinc stearate, calcium stearate, zinc palmitate, magnesium myristate, zinc laurate, zinc undecylenate and the like.

(9) Gum, sugar or water-soluble polymer compound gum arabic, benzoin gum, dammar gum, guaiac butter, Irish moss, karaya gum, tragacanth gum,
Carob gum, quince seed, agar, casein, lactose,
Fructose, sucrose or its ester, trehalose or its derivative, dextrin, gelatin, pectin, starch, carrageenan, carboxymethyl chitin or chitosan, hydroxyalkyl (C2-C4) with alkylene (C2-C4) oxide such as ethylene oxide added. )
Chitin or chitosan, low molecular weight chitin or chitosan, chitosan salt, sulfated chitin or chitosan, phosphorylated chitin or chitosan, alginic acid or its salt, hyaluronic acid or its salt, chondroitin sulfate or its salt, heparin, ethylcellulose, methylcellulose, carboxymethylcellulose , Carboxyethyl cellulose, sodium carboxyethyl cellulose, hydroxyethyl cellulose, hydroxypropyl cellulose, nitrocellulose, crystalline cellulose, polyvinyl alcohol, polyvinyl methyl ether, polyvinyl pyrrolidone, polyvinyl methacrylate, polyacrylate, polyalkylene oxide such as polyethylene oxide and polypropylene oxide. Or its cross-linked polymer, carboxyvinyl polymer, polyethylene N'imin like.

(10) Surfactant Anionic surfactant (alkyl carboxylate, alkyl sulfonate, alkyl sulfate ester salt, alkyl phosphate ester salt), cationic surfactant (alkyl amine salt, alkyl quaternary ammonium salt) ), Amphoteric surfactant:
Carboxylic acid type amphoteric surfactant (amino type, betaine type), Sulfate ester type amphoteric surfactant, Sulfonic acid type amphoteric surfactant, Phosphate ester type amphoteric surfactant, Nonionic surfactant (ether type nonionic Surfactants, ether ester nonionic surfactants, ester nonionic surfactants, block polymer nonionic surfactants, nitrogen-containing nonionic surfactants, other surfactants (natural surfactants) , Protein hydrolyzate derivatives,
Polymer surfactant, surfactant containing titanium / silicon,
Fluorocarbon type surfactant) etc.

(11) Various vitamins Vitamin A group: retinol, retinal (vitamin A
1), dehydroretinal (vitamin A2), carotene, lycopene (provitamin A), vitamin B group: thiamine hydrochloride, thiamine sulfate (vitamin B1), riboflavin (vitamin B2), pyridoxine (vitamin B)
6), cyanocobalamin (vitamin B12), folic acid,
Nicotinic acid, Pantothenic acid, Biotin, Choline,
Inositols, vitamin C group: vitamin C acid or its derivative, vitamin D group: ergocalciferol (vitamin D2), cholecalciferol (vitamin D3),
Dihydrotaxosterol, vitamin E group: vitamin E or its derivatives, ubiquinones, vitamin K group: phytonadione (vitamin K1), menaquinone (vitamin K)
2), menadione (vitamin K3), menadiol (vitamin K4), other, essential fatty acid (vitamin F), carnitine, ferulic acid, γ-oryzanol, orotic acid, vitamin Ps (rutin, eriocitrin, hesperidin), vitamin U etc.

(12) Various amino acids Valine, leucine, isoleucine, threonine, methionine, phenylalanine, tryptophan, lysine, glycine, alanine, asparagine, glutamine, serine, cysteine, cystine, tyrosine, proline, hydroxyproline, aspartic acid, glutamic acid , Hydroxylysine, arginine, ornithine, histidine, etc., and their sulfates, phosphates, nitrates, citrates,
Alternatively, amino acid derivatives such as pyrrolidonecarboxylic acid.

(13) Various additives derived from plant or animal-based raw materials These are processed (for example, crushed, milled, washed, hydrolyzed, or hydrolyzed by a conventional method according to the product type and form to be added. Fermentation, purification, squeezing, extraction, fractionation, filtration, drying, powderization, granulation, dissolution, sterilization, pH adjustment, deodorization, decolorization, etc. are selected and combined), and various materials are selected. You can select it and use it.

The solvent used for the extraction may be selected in consideration of the purpose and type of the product to be provided, the processing to be performed later, and the like. Usually, water, methanol, ethanol, propyl alcohol, isopropyl is used. Alcohol, lower alcohol such as butanol, isobutanol or hydrous lower alcohol, polyhydric alcohol such as propylene glycol, 1,3-butylene glycol, glycerin or hydrous polyhydric alcohol, various organic solvents such as acetone, ethyl acetate, etc. It is desirable to use one or a mixture of two or more of them. However, when the content of the organic solvent is not preferable depending on the application, only water may be used, or ethanol that is easy to remove after extraction may be used and used alone or in any mixed solution with water, or Exploited extract may be used.

Additives derived from plant or animal raw materials are
When used as a systemic or topical external preparation, cosmetics, including protection of skin and hair, moisturizing, improvement of touch and texture,
Giving flexibility, reducing irritation, relieving stress caused by fragrance, activating cells (preventing cell aging), suppressing inflammation, improving skin and hair quality, preventing rough skin and improving it, hair growth, hair growth, hair loss prevention, gloss , Cleaning effect, relief of fatigue, promotion of blood flow,
In addition to cosmetic effects such as warm bath effect, fragrance, deodorant, thickening,
The effects of antiseptic and buffer can be expected.

In addition, in food and drink, nutritional supplementation, recovery from fatigue, tonicity, healthy and cosmetic effects such as cell activation (prevention of cell aging), improvement of taste, imparting of color tone, aroma and luster, stabilization, It can be used for the purpose of thickening and preserving. In addition to this, expect various various cosmetic and pharmaceutical effects of each raw material known so far, and aim to enhance the desired effect by combining these.
Alternatively, the product can be expected to have a multi-functional effect.

As a concrete plant (crude drug) used as a raw material,
For example, almonds, ai, blue vines
(Seifufuji), Aoki (Aoki), Aogiri or Kenashiaogiri
(Goji paulownia), Aotsutsurafuji (Kibo), Aotenma, Acacia, Red capsicum (Akasoma), Redcurrant `` fruit '', Red clover, Red grapes, Red amber (Logwood), Red algae (Red bud), Red pine or Red madder or Red madder (Akane) (Grassroots), Akagia jiou or jiou (ground yellow),
Agi (A Wei), Aki Larch, Akinire (Resin), Aguay Gua Su, Aguahe (Omi Tenguyashi), Akebei
(Ki-dori), Asa (Asakojin), Malva Morning Glory or Morning Glory
(Dagushi), Hydrangea (hydrangea), Ashitaba (tomorrow leaf), Azuki (red azuki bean), Asunaro, Acerola, Asenyak (Asenyaku), Athira (Sakuyoukanna), anise, abiu, abiulana, canola, abemaki "fruit" ,Avocado,
Ama, Amacha (sweet tea), Amachatsuru, Amadokoro (Tamatake), Amana (Kokoji), Amaranthus (Hiyu, Hagatetow, Himegateto, Senninkoku, Sugimorigateto,
Hosoaogatetou, Aogatetou, Haribiyu, Aozulan, Amaranthus hippocondriacus), Amigasa lily or Fritillaria (shellfish), Aristromelia (Yurizuisen), Arcana (Arcanna), Algarrobo (Cabbage), Artea, Arnica, Alpinia or Katsumadai
(Souzuku), aloe (蘆 薆), aloe vera, angelica, apricot or hon apricot (apricot kernel), ansokkou (benzoin), yellow sapote, igakoukousrina (geijutsu), sardine or chinensis (indian cabbage), rush
(Wicked grass), Japanese knotweed (Kojo root), yew (first place), strawberry,
Fig (flowerless "fruits and leaves"), figs (first), hibiscus (winter aoi), Ichiyakuso (one medicinal herb), ginkgo (ginkgo biloba "seed, leaves"), Itohimehagi (distant), locust bean, Inunazuna (Taylexi) , Inubiyu (Honagainubiyu), rice "seed, seed coat", inondo "seed", Echinochloa japonica, nettle, ylang-ylang, iwatobacco (Iwabaki),
Iwahiba or Iwamatsu (wind roll), common bean, oolong tea, fennel (incense), wheat (Chibana), ukiyagara (Sanryo), Uguisukagura "fruit", Himeyokiou, turmeric (Yukin), duckweed (Ukiwa), Usubasaishin Or Keirin saishin or Sengoku saishin (spicy), mussels mallow, mung bean mallow, medusa orchid, nemophilus (summer hay), udo or shishido (invigoration, independence, indonesia), unyadegat (unkalia, cat's claw),
Uba Tea, Ume (Ume "seed, fruit pulp"), Vladimir Ogashira, Argentine (Rawberry), Unshu Mikan (Chenhide), Umboku, Estragon, Ezo-kogi (Ezo Goka), Ezo Suzuran, Echinashi (Hosobamurasakibareniku, Echinashi), Enishi Mushrooms), Ebisugusa or Cassia tora (Keiko), El Campre, Elderberry "fruit",
Elemi, Eryngii or Pre-Lotus erynge, Enju (Sophorae, Sophorae rice), Pea, Ougi or Kibanana
(Yellow radish), Naruco lily or Kagi Kurumabanaruko Yuri (Yellow), Ohihisasanoyuki or Sasanoyuki, Ouren (Yellow), Ogata Houken, Ookarasuri (Calocon),
Plantain (Civil engineering incense), Giant tsuboji (Self-defense), Plantain
(Carmaco, Carophyllum), Milk thistle (Yuzhou Leopard, Bald Ear), Toucan Hazel (Haruko), Toucan Cactus, Obana Ochera or Ochera (White Sprout), Obana Sarsberg (Banaba), Ooba Yashaboshi "Fruit", "Fruit" Grains), Oomiacatetsu, Omihawthorn or Hawthorn
(Yamashiko), Omiyashi, Barley (barley), Oka, Okazeri (Heiwako), Okra "fruit", Oguruma (overturning), Oklurihigotai (Banzhou Leopard, Indigo Spin), Panax ginseng or Panax ginseng (carrot) , Odorikosou (intermittent), Onamomi
(Blue ear), Onigurumi, Onidokoro or Tokoro or Nagadokoro (Hikai), Oninoyagara (Tenma), Oniyuri or Sasayayuri or Hakatayuri (Yuri), Onoelan, Ononis,
Halibut (Yoha Yu), Ominaeshi (soy sauce), Oyuko, Dutch mustard (cresson), Dutch jelly, Dutch biu,
Dutch honeywort, olives "fruit, seeds, leaves", oregano, orange "fruits, pericarp", cauliflower (ripe ground yellow), cacao "fruits, pericarps, seeds", oysters (persimmon "leaf"), swordfish (fishing rattle) Hang), oyster or citrus (Lotus japonicus), oyster, hydrangea, Cassia, casino cypress (pure fruit "fruit"), banyan tree (camellia), kasiwa (casukila, cabbage leaf), cascarilla, gypsophila, Kasenso, cypress (Kinshato), kaniwa, carnation, valerian (Yoshikusa), hippo, birch or birch (birch), gerbera, pumpkin, kapok cypress `` seed '', kahokusansho (lichen), gama (garden yellow), chamomile Or Roman chamomile, chamomile (weed), cam cam
(Duck), color, swordfish, crow cucumber or cinnamon cucumber (king melon), crow bishaku (half-summer), oats, guarana `` seed '', callahoo (bamboo), karaya, garyu, karin (wood melon), garcinia, kawamidori, kawarasaiko (Koryo greens, white grass), kawajisha, kawaratake, kawaranadeshiko (ishitake) or ezokawaranadeshiko (green oats, barley malt), kawaran carrots (green cabbage), kawara mugwort (sea peony), kansui (sweetened), kanzo (kanzo). Licorice), cantara, candilla, canto, canna, cannabis, raspberry (ezo strawberry, dutch strawberry, shrimp strawberry, nawairo strawberry, maple strawberry, european raspberry),
Kiwi "fruit, leaves", squid cucumber (urine root), kyokyo
(Kikyo, Kikyo root), chrysanthemum (Chrysanthemum, chrysanthemum, chrysanthemum), Kikutanigiku, Catalpa (Azusa fruit), Rumex
(Yotei), Kizitsu (Kuromi), Kizuta, Kidachi Aloe, Kudachi Mint, Kina, Kinonaki (Shinkona, Red Kinaki), Quinua (Kinoa), Kihada (Yellow Kashiwa), Kimame, Gymnema sylvestre, Kimenkaku, cabbage, cabbage "unripe fruit" , Caraway, cucumber, gyoryu (Nishikawayanagi, Teiyanagi), Kiraja saponaria, Kiraya, Kiranso (Kenshi small grass), kumquat "fruit", kinkju, ginsekikai, kumbusen, kimuma, kimimizuki (senzuru kusa),
Kinran, Ginran, Kinryohen, Guapaba Vermelha, Guava "Fruit", Guayule, Quercus Infectria (galaxy), Kukui nuts, Kugenumaran, Cuco (lilies, limbs, limbs, cicadas), Kusagikazura Kudzu (Kudzu root), camphor tree, gooseberry "fruit", Xantheng carrot (Yellow lance), Kutiti River, Gardenia (Yamasuko), Kunugi (Garden root), Cupua, Kubeba, Kumazasa, Vermella, Clara (bitter) three),
Cranberry "fruit", chestnut "seed, fruit, astringent skin", curculigo latifolia "fruit", grapefruit "fruit / leaf", buckthorn, black ganemochi (necessity of rescue), clove (clove, clove incense), gumbina zuna (sekimei, sekimeiishi) ), Keigai (Maggot, Messhou), Keitou
(Corolla flower, colander), geckavidin, bay (laurel), kenashisartoriibara (earthen peony, mountain return), gentian, gennoshoko (old bird grass), kenponashi (kigushi),
Kouki Sekkoku, Kishikan (Koji, Tachibana,
Oven mandarin orange, Fukuro mikan, Koji sagami, Ponkan, Santara (tachibana peel)), Kosimbara (moon flower), Kosui mint, Kozo `` fruit '', Kocha (tea), Kouhone
(River bone), Kouhon (Straw book, Karamoto book), Kouryan, Kouryokyo (Kora ginger), Cilantro “fruit”, Kouren
(Kohren), Scutellaria (yellow gon), cowberry (Koshitachi), coconut "fruit", goshuyu (goshu 萱), gosho strawberry (covered bonito), pepper (pepper), cosmos, copaiba balsam,
Coffee `` seed, leaf '', kobushi or magnolia (spicy pepper), burdock (burdock, burdock), kobodzu, sesame (sesame), sesame nohagusa (genus), gojishiza or binanakuzura or matsubusa, wheat (wheat). , Rice or rice bran "Aka bran, Shiranuka", rice oil, cola acluminata "seed", cola vera "seed", colony lya, fenugreek "fruit",
Colombo, Conzulango, kelp, konjak, konfuri (final grass), sisal (sisal asa), saihairan, sakaneran (ezosakaneran), saxima button vine or sycamore vine or chinensis (weapon), sakura (oshimazakura, yamazakura, oiyamazakura,
Ed Higashi, Mamezakura, Miyamazakura, Yoshino cherry tree, Takanezakura, Kasumizakura, Kohigan, Satozakura, Kanzakura "leaf, flower, fruit, bark (cherry bark)"), cherry, pomegranate, sasa, sasabaginran, sasanka, sadiomodaka (sawamai, sakurai), sasaki Sugar cane, sugar beet, rapeseed jujube (Natsumejin), saffron
Western safflower), sapodilla, sapotea mario, pomelo "fruit", saponsou, salmon berry "fruit", sala cinnabar (maen), salanshito (sand indigo stab), swordfish (mountain spinach), sour walnut (mountain walnut), sankaku cactus ,
Sangre Degrad (Croton), Hynobius communis, Panax notoginseng (37 ginseng), Sanshuyu (Yamatake), Sansho (Pepper), Sandscon (Mountain bean root), Shea (Carite), Cyanoki `` fruit '', Shiitake ( Shiitake Mushrooms), Shion (Shien), Shikakumame, Digitalis, Shikunshi (Shikunushi), Perilla or Aojiso or Chimenjizo or Catamendiso (Shiso Leaves, Shiso), Rosewood, Shina Honoki, Shinarenkyo (Renshi),
Shimeji (Hinjimeji, Shakamejime, Hatake Shimeji, Oshiroijimeji, Beech Shimeji, Honjimeshi, Shimotake Mushroom), Shimokuren (Spicy), Apiaceae, Potato,
Peonies (peony), shajin (samseng), jasmine (matsuryka), january beard (barley winter), juvenile cowpea, gypsophila, shukshamitsu (sand kernel, curd sand), juzdama, palm "fruit", shunlan, Palm oil palm, ginger (ginger), hydrangea hydrangea (tsuneyama), ginger (iris, iris root), shozuku "fruit", white oak "seed", silane (butterfly), white-billed butterfly "seed",
White clover (white clover), White Azuki (chicken bone grass),
White squirrel (Small squirrel), White vine, "Flower",
White lupine, Shirominanten (southern Tenmi), Cinchona Succibula, Jinchoge (Mizuka, Mizukaka, Shichohana),
Cinnamon, Cinnamomum cassia, watermelon
(Watermelon), honeysuckle (gold and silver flower, Shinobi winter), sorrel (acidic), swim berry `` fruit '', star apple, stevia, strawberry `` fruit '', Suzuko (Lord Xu), horsetail (question), purslane (horse toothpaste,) Horse tooth Kenko), plum "fruit", sulgalan (orang), red pine "cone", Japanese larch, western quintet, walnut, hawthorn, hornbill, dandelion, horse chestnut (malonie), pear "fruit" ], Natsumiyukiso, Sambucus nigra
(Elder), Pacific jelly (Juniper, Juniper), Yarrow (Millfoil), Rose, Astragalus vulgaris, Mistletoe, Peppermint or Peppermint, Horseradish, Budgerigar
(Ishikon), Ginkgo (Cherry Blossom, Kouki Ginkgo, Oanabashi Ginkgo, Okinawa Ginkgo, Hon Ginkgo, Ginkgo Ginkgo, Shikaku Ginkgo, Kibanano Ginkgo) (Dendrobium, Ishibuchi), Cedron (Boshishuboku), Henasei, Henosei, Henosei, Henosei, Heisei Oise, Hire Celery, senkyu (river kyu), senshinren (shinshinren), sendan, sennin cactus, senna "fruit, leaves", ninninsou (daiba), senburi (this medicine), senboku, souka
(Grass fruit), elephant chow, buckwheat syrup, buckwheat "seed seed", some potatoes, broad bean, rhubarb (daikon), radish, soybean, daidai (orange peel, drought), takasagogorurihigotai (south indigo indigo head), takasaburo (drought lotus) ), Takatodai
(Ohji), Takawarabi (in Japanese), dark sweet cherry "fruit", hollyhocks, pearl oysters (thyme, lily scent), tadikoro (hikai), tachinyanagi, tamarind "seed", onion, tamshiba (spicy), taranoki "fruit" , Leaf, root bark ", tarayo (Oba winter blue, one leaf tea, bitcho tea, bitter tea), dahlia (tenjiku button), tarui, tankimimame, tanchiuchiwa, tanjin (danshen), dandelion
(Kamahide) or white dandelion or moco dandelion, danmar, cherry "fruit", chigaya "fruit, root, bud",
Ginseng carrot (Chicken ginseng), chicory, chanka piedra (Kidachi-kansou), tulip, choconostay, artichoke (artichoke), ginseng (daikon), ginseng (garden), ginseng (agar leaf), chorei Maitake (boiled boar), Chorogi, Tsukimiso, Tsukusakaneran, Tsukuritake (mushrooms), Tsuchiakebi, camellia, Centella asiatica, Tsumekusa (lacquer grass), Tsuyakusa (Duck sedge), Tsuzuki adzuki beans, Tsurutsudachi Ami, Tsurutsudachi Ami, Tsurutsudachi Ami, Tsurutsudachi Ami. Tsuruna (Apricot radix), Ginseng (Folia ginseng), Glycine soja, Tsuwabuki, Deiko, Ganoderma lucidum, Duberry "fruit", agar beetle, tencha
(Japanese tea), Tendaiyaku (crow), Toga (winter gourd), Tokagi quail, Capsicum (Pepper), Touki (Toki), Sugar beet (Marigold), Toukikachi, Tounabena
(River cut), corn or corn hair (nanban hair), squirrel mochi (sadako), gentian or ginseng (dragon gall), horsetail (tree bandit), dokudami (ten drug), turmeric
(Root), Toshishi or bean bug or Nashikazura, Eucommia (Dunaka "bark, leaves, roots"), Ash (Hata peel), tomato, tragacanth, Triacanthus "seed", Eustoma grandiflorum, Tormentilla, Dronoki, Torohoaoi, Tonlock bean, Nigeria Berry "fruit", Chinese yam or yam (mountain drug), Nagikadada (Butcher bloom), Naginatakouju, Nazuna, Rapeseed, Bean bean or Tatehaki
(Sword bean), Natsumikan, Jujube (Otsuki), Naniwaibara (Kinzako), Navena (interrupted), Nameko, Peanut (peanut), Nanten (Minami Tenmi), Nanbankaramushi (Romasa), Nioisumire, Nigaki (Bitter) Tree), sagebrush (bitterness), nutmeg, kei or nikkei or ceylon nikkei or yab nikkei (cinnamon) or cinnamon (keishi), sycamore, leek
(Nirago), elderberry (bone grafting `` fruit, flower, stem, leaf ''), garlic (large garlic), nullde (quintet), leek, nemoki or nebu or nevi or nemlinoki or digobana (negro), thistle (daikon) , Noibara (Yuyomi), Noseden vine (Ryohika),
Nogetou, yarrow, Nodake (pre-hu), Novara, peach, pineapple "fruit", hibiscus (Bussouge, Furinbussouge, Roselle), Hyelindo,
Hachiwa, Pau Dose, Hakamaurabosi (bone fracture supplement), Hakukayumato, Hakusan Chidori, Hakusen (tinea versicolor), Hakulberry `` fruit '', Hakobe (prosperous), Hazel (Haruko),
Hasiridokoro (roth root), basil, lotus (lotus, lotus, lotus root), parsley (netherlands jelly), hadakamugi, batata, bee or madake (boiled bamboo), patchouli, peppermint (light load, light load leaf), peppermint, pearl barley ( Yokuinin), Hananasuge (Chinese mother), Banana, Hanamint, Hanabishi (Shirushi, Shishitsuri), Vanilla Bins, Papaya, Yellow-footed
(Mouse koji), pahalobobo, hub `` whole grass, stem, leaves '', paprika, sea peony, hagumou or mitsuba hamago (vine vine), hamasuge (kazushi), hamabishi (shitsuriko), hamanasu (maikai flower), Hamabofu (Hama Windbreak), Hamamelis,
Palm, rose (rose), balata, balata gum, agaric (aratake, white-bellied agaric, Uskimorinosaka), Haran, Paliurus (Hamamatsume), Parietaria, Harkanlan, Balsamina (Tsurureishi,
(Nigauri), Harunire (black leather, white leather, yellow leaf), Barbasco, Harlindou, Handaikai (Yu Taikai), Panoki,
Hyogi (dried dry), carrot (carrot), pecan nuts, hemlock (stone garlic, vine pearl scent), Higulmadaria, higotai, Hishi (hishimi), pistachio, beet, honeywort (stone reed), hydrangea, daisies (daisy),
Hinako no Kochi (cow knee), Hydrangea cypress, Japanese cypress, Hiba, castor, sunflower, green pepper, Himeuzu (Aoi), Himematsu (scented), Himematsutake (Kawariharatake, Hiromatsutake), Himemu orchid, Pimentha "Fruit", Biyaku, Biyaku Hiyu "Fruits", Chickpeas, Flounder, Broadbill, Oyster Flower (Bald Ears), Loquat "Fruits, Leaves, Stems", Areca (Large skin, calyx), Pu'er tea (Fu-cha), Futokazura (South rattan) , Butterbur, butterbur dandelion (submarine winter flower, subterranean winter leaf), wisteria mackerel (orchid), wisteria beans
(Foliage), Fujimaki (Chrysanthemum japonicum, Fusarium japonica), grape "fruit, fruit skin, seeds, leaves", beech, Fuyusuminatsutaketake (Coleoptera), Brazilian licorice, Brazilian carrot,
Brazilian palm, Brazilian elephant palm, black currant "fruit", blackberry, blanchen, plum "fruit", fulceraria, blueberry (Himesuoki), prunes, floral blanka, blonde psyllium, bundou (mung bean), hazelnut, loofah ,
Hetkalan, safflower (safflower), Henneken, belladonna,
Berries "fruits", Persear, Perbianberg, Pereschia grandifolia, Bengal millet or duckweed
(Keiten), Boysenberry `` fruit '', Houki, Ragweed, Nendou or Hahakigi Kokia (ground skin), Hosairan, Hosenka (Housen, Acute child, Bone grass), Pouteria sapota, Pouteria lucuma, Honoki, Bowfu
(Windbreak), spinach, physalis (Torone), honoki
(Wakoboku, magnolia), bokeh (wooden melon), mosquito abragiku (bittersweet), mosquito grass, mosquito serrata (sorrow), buckwheat syrup (Kageten Sanchi), moss barren ginkgo, button
(Peony `` flower, leaf, stem, bark ''), button pi (peony skin), hops, jojoba, borage (luricha), bordeaux, white berry `` fruit '', hononiku (meat juyo, arts), honsekoku (iron) Haruishi, Suzuyama Ishiha), Maizuru Tennan Show (Tennansei), Maitake (Maitake), Maou (Maoh), Maca, Macadamia nuts, Margaret (Mokshungiku), Macri (Marine grass), Magui (Mulberry white skin) `` Bark, leaves ''), Magnolia splengeri, Masalanduba, Masalanzuuba de Ceara, Masheira de Boi, Mashua (Tamanouzenhalen, Rhinoceros chinensis), Matatabi (tree tenderflower), Matsukasa, pine `` leaf, bark, Roots ”, Matta Orho, Matsuhodo (Road), Matico (Cordonsillo), Mayorum (Hanajaca), Marvanojazin (Buffalo), Mulberry“ Fruits ”, Quince, Marais Mango, Mangosteen, Manzania (Andes chamomile), Manshugurumi, Mandarin "fruit",
Ganoderma lucidum (Ganoderma lucidum), Pheasant (Gourmet `` Fruit ''), Mishima Psycho (Saiko), Water plantain or Water morning glory (Rhinoglossus),
Mizokukushi (Half-sided lotus), Misohagi (Senkyaku), Michiyanagi or Niwayanagi (Henji), Mitsugashiwa, Mitsuba, Midori Zapote, Midorihakka, Mimosa, Myoga, Miracle Fruit "fruits", Myrrh, Myrobalan, Mugiwaragiku, Mukuge , Mukunoki, Mukuroji (prolonged skin), Munya, purple (purple root), purple syrup or purple syrup
(Purple), purple corn, purple fuji (Kunmei chicken blood wisteria), megakansa opuntica, swordfish (beneficial herbs), barley, melaleuca, melissa, meliloth,
Melon "fruit", Mokoyomogi, Moso bamboo, Mokugirin, Moje (pepper), Mochinoki, Mokko (tree incense), Japanese maple, Peach (peaches "leaves, seeds, flowers, fruits"), coconut, morello cherry "fruit" , Moroheiya
(Burlap), yakawamurasaki yak, yakchi (maschi), cornflower (cornflower), cornflower, yacon, yashabushi (arrow wheel) or Himeyashabushi or Obayashishabushi "fruit, fruit skin, fruit ear", yam willow, yam depot (octagonal metal plate) , Mistletoe (willow parasitism), willow (Kiyanagi, Tachiyanagi, weeping willow, red willow, cat willow, dog cory willow, willow willow, cory willow, unryow willow, willow willow, palm, willow willow, willow willow,
(Tailuku nuyanagi, fox willow, doronoki), willow tree "leaf, stem", porcupine, yam koji (purple gold cattle),
Yab Tobacco (Tsuru, Tenmei), Yamabobo (Shokuryoku), Yamanoki (Yamaharu), Yamamomo (Yangume), Yamamogomi, Eucalyptus, Yukinoshita (Tiger's ear grass), Yucca or Flavifolia, Yuzu `` fruit '', lily, Yellow primrose, mugwort (moth leaf),
Rygan (thunder circle), lime "fruit", rye, raspberry "leaves and fruits", latania (clamellia), lacquer or shallot (seed white), lavender, longan (dragon eye meat), agave lantern (aono eucalyptus, fukurin agave), ryokcha (a). Green tea), apple "fruit,
Seed, leaf, root ", gentian, rubus or Suabisimus
(Tsuyo Ryo), Ruritama thistle (Varadigo higotai, Xinjiang stab head), Reishi (Lichie, Lichia nucleus), Lettuce (Chisha), Red currant `` fruit '', Red pitaya, Lemon `` fruit '',
Lemongrass, Forsythia or Forsythia (Forsythia),
Astragalus, Rhizoma, Waxy, Locon, Reed, Rhizoma, Loganberry "Fruit", Rosemary (mannen wax), Rosehip (Novara), Wasabi, Cottonweed (Japanese sage flower), Waremoko (Small ground) Etc.

As the seaweeds, there are seaweeds [green algae: Chlorella vulgaris, Chlorella pyrenoidosa, Chlorella ellipsoidia, aonori (Usubaaonori, Sujiaonori, Hiraaoonori, Bouaonori, Hosoedaonori), Anaaosa (sea algae), Kind: kelp (Macombus, liquorice, Hosomekonbu, Mitsuishikonbu), wakame, hirome, aowakame, giant kelp (macrocystis pilifera, macrocystis integrifolia, neocitrus ruetokeana), hijiki, hibamata, sea uchiwa, usubaumiu Kirebanoumiuchi, Akabatumiuchi, Konaumiuchiwa, Okuchiuchiwa, Usuyukiuchiwa, Echiukiumiuchiwa], Seaweed [Red algae: Hijirimen, Hakusa, Hirakusa, Onik , Obakusa, Kataobakusa,
Yatabegusa, Yukigiri, Amanita, Tosakanori, Togekirinsai, Amaxakirinsai, Giraffe, Jakushinkirinsai, Tsunomata, Obatatsunomata, Tochaka (Nyakuzuna-no-Tomashita), Ezotsunomatsuta, Togenomata, Hirasakonotoma, Kotobuki, Kotobuki, Kotobushi
[Yaleus Banori, Kagious Banori, Suzius Banori, Haius Banori, Akamomijinori] and the like.

In addition, other algae such as green algae (Chlamydomonas: Chlamydomonas, Akayukimo, Dunaliella: Dunaliella, Chlorococcus: Chlorococcus, Anemone: Quanonimo, Volvox: Ohigewawari, Volbox, Palmera, Yotsumeu, Genus Aomizu: Hizaori, Ao midori, Genus Tsurugimido, Genus Himidoro: Hibimidoro, Genus Aosa: Anaaosa, Amiosa, Nagaaosa, Kawanori: Kawanori,
Fruicula genus, Shiogusa genus: Oenothera genus, Asamidoriushigusa, Kawashiogusa, Marimo, Baronia genus: Tamagobalonia, Tamabaronia, Magatagum genus: Magata, Iwachia genus: Fusaiwaduta, Black squirrel, Mildewer, Black millet, Nematoda, Hagemonia, Nematoda. Sakibutimir, Nagamir, Hiramiru, and Kasanori:
Casanori, genus genus: Futozuzumo, Tamazuzumo,
(Mizujuzumo, Mikadzuki genus, Colecaete genus, Tsudumimo genus, Kikkokusa genus: Kikkokusa, Astragalus genus: Hitogusa, Hirohanohitohegusa, Usutoegusa, Motukihitoe, Sayamidoro, etc.

Cyanobacteria (genus Suizenjinori: genus Suizenjinori, genus Algae, genus Nostoc: Kawatake, Nostoc commune,
Hassai, genus Yuremo, racenmo (spirulina) genus: spirulina, trichodesmium (aiacacio), etc.).

Brown algae (Pyraera: Pyraela, Shiomidoro: Nagamisio Midoro, Isogrape: Isogrape,
Genus Isogawara: Isogawara, Kurogashira: Gunsen Kurogashira, Kasakizaki: Kazakizaki, Muchimo: Muchimo, Hiramuchimo, Keperigusa, Astragalus: Astragalus, Sakibirohajiza, Sanyuhajihadosa, Azagusa saga: Common sage: Common clover, Common clover Prickly squirrel, Ulaboshihaha, Symphalida: Symphologus, Cyperus genus: Cyperus cypress, Konaumi uchiwa, Akabayumi uchiwa, Namikura genus: Prunus chinensis, Somexaceae genus: Somenaceae
Pinus genus: Matsumo, Nagamatsu genus: Nagamatsu moth, Okinawa mozuku genus: Okinawa mozuku, Niceft mozuku genus: Physcomit genus, Physmozuku genus: Physcomitum genus: Genus mosquito: Genus mosquito: Genus moss, Genus moss Isige, Iroro, Ichimegasa genus: Ichimegasa, Keyari genus: Keyari, Umibosu genus: Umibosu, Urushigusa: Urushigusa,
Black cypress, Tobacco bug, Genus: Haemorium, Haberdoki: Haberodoki, Havanori: Havanori, Habernori: Hazelnut, Common genus: Common butterbur, Ezoburo genus: Nematode: Nephila, Rhizophora, Rhizophora, Rhizophora, Rhizophora, Rhizophora, Pleurotus vulgaris Genus Kagomenori: genus Kagomenori, genus Muralis: murachidori, genus Phalaenopsis: shark
Sardine: Sardine, Asclepias: Asclepias, Kayamonori: Kayamonori, Fennel genus: Fennel, Tsurumo: Tsurumo, Anata: Squirrel, Susume: Aedes albopictus, Missus konjac, Miscanthus, Aedes radisculent, konjac beetle, konjac beetle, scutella conserved , Onikonbu, Goheikonbu, Nagakombu, Pea kombi, Otojijimokubu, Tororokonbu genus: Tororocombu, Antocume: Antokume, Kajime: Kajime, Tsuruarame, Kurume, Chrysanthemum genus: Chrysanthemum genus: Necrochamus genus, Black konjac genus, Black locust, Black civet, : Catfish,
Genus Alame: Alame, Ainu Wakame, Ainu Wakame, Chigaiso, Oniwaka Ezo Ishige: Ezo Ishige, Yabanemoku: Yabanemoku, Rappamok: Rappamok, Jolomok: Ugananomoku, Jolomok, Hiemoku, Honduramaku, Isamanidae, Tamanashira Akamoku, Shidamok, Hondawara, Nejimoku, Narasamo, Mametawala, Tatsukuri, Yasumatamok, Umitranano, Obamamok, Fushizushimok, Hahamok, Togemoku, Yoremoku, Sugimurakoku, Sugimurakoku, Sugimurakoku, Sugimoku, Sugimoku, Sugimoku
Burukkimo, genus Kayamonori: Kayamonori, etc.).

Red algae (genus: Kensuke Nori, Funori Nousuke, genus Noriophyra: Asakusanori, Susabinori,
Upruinori, Onia manori, Tasa, Fuiritha, Benitasa, Rhodocorton: Milnobeni, Akebono Mozuku: Akebono Mozuku, Konahada genus: Hikonahada, Yogorekonahazukuni Azukuniboku, Azusa konjac, Azusa konjac, Azurus chinensis, Azurus chinensis, Azulina serrata, Azurus serrata, Scorpionaceae. : Pine pine, Fusanori genus: Fusanori, False genus: False genus,
Genus Sodegari: Sodegarami, Rattle Genus: Rattle, Rattle, Hilotatamaidae: Hirohatamai Taki, Tamai Taki: Tamai Tadaki, Kagenokiri: Kagaminori, Kaburi, Hibachi, Hibachi, Hibachi, Hibachi, Hitenagao, Hitengusa, Hitenagasa, Hitenagasa, Hitenagai Genus: Hihibiroud, Hibihibiroud,
Pteridophytes: Pleurotus, Pleurotus: Pleurotus: Rumex, Ryumonsou: Ryumonsou, Hera Ryumon, Nymphalaceae: Nisekarekigusa: Okitsubara genus: Psyllium syllabus: Acacia
Naminohana, Coral Spodoptera: Rattlefish, Shiogusagoromo: Shiogusagoromo, Ivanoka genus: Etsukiiwanokawa, Kainokawa: Kainokawa, Kanitonote: Kaninote, Corydalis, Dendrobium, Scutellaria, Dioscorea, Rhizophorus, Scutellaria, Saccharomyces , Tambanori, slippery,
Fudaraku, Maruba Hudarak, Isonohana: Nurakusa,
Black knuckle, Ginkgo biloba, Japanese quince: Japanese quince, Japanese quince, Japanese quince, Japanese quince, Japanese quince, Japanese quince, Japanese quince, Japanese pine tree, Japanese pine tree Nagaobane genus: Nagaobane,
Genus: Hanafunori, Fukurofunori, Mafunori, Kaligukisa: Pachydermia japonicum, Podocarpus genus: Hosobanotokaomodoki, Hirohanotosakadoki, Yatsudegatatokadoki, Kurotosakatodoki, Katodoki, Katodoki, Katodoki, Katodoki Doki,
Himetosakadoki, Kinuhada genus: Kinuhada, Ezotosaka: Ezotosaka, Tsukasanori: Enashikarimenia, Otsukasanori, Hanagatakarimenia, Honoo: Honoo, Hichinagenasu, Nihonbunio, Nihonburonoo Pleurotus cornucopia, Okamuragusa:
Yamadagusa, Mirin: Mirin, Hosobamirin, Tosakanori: Kikutosaka, Ezonameshi: Ezonameshi, Isomokka: Isomokka, Yukari: Yukari, Hosoyukari, Ibaranori: Ibaranori, Saidaibara, Tachiibara, Kadikio Nori, Phytophthora alba Spodoptera litura, genus Astragalus: Astragalus,
Genus Ogonori: Ogonori, Cranegrass, Shiramo, Ozonori, Mizookonori, Cabana Nori, Beniogonori, Fukuroshinonori, Muranosakinogoonori, Scorpionaceae, Scutellariae, Scorpionoris , Amanita genus: Nectaria vulgaris, Fushiklenori genus: Fushiklenori, Namibia genus: Pleurotus cornucopiae, Cyprinidae: Pleurotus genus, Periwinkle genus: Periwinkle, Prunus genus: Pleurotus genus: Simi, Hedgehog, Lotus japonicus
Lotus japonicus, Scutellaria: squid reeds,
Novonori, Black-headed genus: Black-headed ginsou, Red-headed genus: Red-headed ginsou, Rhizoma genus: Hishibukuro, Madaragusa: Scutellaria, Etsukimadara, Taogo-nagien: Taogosou, Hanasakura, Haduna, sugi , Hiratao goat genus: Hiratao goat, dalus genus: dalus, scorpionfish, anadalus, weebagsa genus: weebagsa, benifukuronori genus: benifukuronori, fushuna genus: fushunagi, himefusutsunagi,
Broadbill, Salix genus: Spodoptera cinerea, Usbawa vulgaris, squid genus: squid, caygis, squid squid, haneigis, axusa, egonori:
Egonori, Futogigis, Saeda: Saeda, Chirimomimushi: Chirimomiji, Konohanori family: Hatabenoori, Konohanori, Suzuronori, Usubini: Usbeni, Hasugiginu: Hasujiginu, Nagausaginohagi, Hausaginohagi, Hausaginohaji, Niusakonohaji, sugi-nosagi, sugi, sugi Yaleus Banori, Suzius Banori, Haius Banori, Usbanorimodoki: Usbanorimodoki, Ayanishiki: Ayanishiki, Agianu:
Ayaginu, Dasia genus: Enashidasia, Shimadsia genus: Isohagi, Shimadaia, Dagimodi: Dagimodoki, Itogusa: Moroitogusa, Futoigusa, Makuri: Makuri, Yanaginori genus: Hana-yanagia, sagiyunayunayunayunayunayunayunayunabenyi, benna : Crosozo, Cobosozo, Hanesoso, Sozonohana, Amaranthus: Ranunculaceae, Raponica, Cozanemo: Cozanemo, Imurasaki, Hosocozanemo, Genus: Mesothraceae, Black-spotted dragonfly, Anemoneaceae, Anemoneaceae, Anemoneaceae, Anemoneaceae, Angustiaceae, Angustiaceae, Angustiformes Astragalus, Rhizophora: Rhizopus, Fujimatsumo: Fujimatsumo, Sawtooth genus: Toothbrush Mushrooms, Kawamozuku: Kawamozuku, A Kawamozuku, Himekawamozuku,
Ideyugogome genus: Ideyukogome, Ochiimozuku genus: Ochiimozuku, Otomogusa, Chichinorimo: Chinorimo, Chisujinori: Chisujinori and the like).

Algae (genus Chara, genus Citra,
The genus Rhizopus: Rhizophyllum, the genus Lichnotamnus, the genus Flamus: Himaflamus, Chaboflamus, Tripera, etc.), the yellow algae (Genus Hikarimo: Hikarimo, etc.), etc.

Materials derived from animal-derived raw materials include poultry extract, cow or pig, human placenta extract, cow or pig stomach, duodenum, intestine, spleen extract or decomposition products thereof, beef or pig. Brain tissue extract, bovine or porcine elastin or elastin hydrolyzate (acid, alkali, enzyme, etc.) or water-soluble elastin derivative, porcine or bovine blood cell proteolytic product (globin peptide), cattle or porcine hemoglobin degradation Products (hemin, hematin, heme, protoheme, heme iron, etc.), milk, casein and its decomposition products or their derivatives, skim milk powder and its decomposition products or their derivatives, lactoferrin or its decomposition products, chicken egg components, fish meat decomposition products , Nucleic acid-related substances (ribonucleic acid, deoxyribonucleic acid), etc.

As the material derived from plant or animal raw materials, any site derived from a gene recombinant or a cell fusion,
Cells, tissues, organs, metabolites, etc. can also be used.
Furthermore, for example, an undifferentiated cell group, a cell group in the process of differentiation, or the like obtained by culturing an arbitrary site, cell, tissue, organ or the like can be used.

(14) Marine components Seawater such as deep water, for example, seawater salt, dried seawater, inorganic salts (sodium chloride, magnesium chloride, potassium chloride, etc.) obtained from the Dead Sea or the Atlantic Ocean or the Pacific Ocean, sea mud Or mud (fango), for example, sea mud or mud of various places such as Italian fango, German fango, Eifelfango, and Freiburgfango (containing components: silicon dioxide, titanium dioxide, aluminum oxide, iron oxide, manganese oxide, sodium oxide, Potassium oxide, magnesium oxide, calcium oxide, strontium oxide, sodium, potassium, magnesium, calcium, chromium, iron, copper, nickel, zinc, lead, manganese, arsenic, water), Seitoku stone, etc.

(15) Microorganism culture metabolite Yeast metabolite, yeast extract, bacterial metabolite, bacterial extract, mold or actinomycete metabolite, mold or actinomycete extract, natto metabolite, natto extract, Fermented rice extract,
Fermented rice bran (red bran, white bran) extract, euglena extract or its decomposition product or water-soluble derivative thereof, trehalose or its derivative, lactic acid fermented product of raw milk or skim milk powder, fermented product of lactic acid bacterium of legumes, lactic acid bacterium of coconut plant Fermented material, etc.

(16) α-hydroxy acids Glycolic acid, citric acid, malic acid, tartaric acid, lactic acid, etc.

(17) Inorganic pigments Silicic anhydride, magnesium silicate, talc, kaolin,
Bentonite, mica, titanium mica, bismuth oxychloride, zirconium oxide, magnesium oxide, zinc oxide,
Titanium oxide, calcium carbonate, magnesium carbonate, yellow iron oxide, red iron oxide, black iron oxide, Gunjou, chromium oxide,
Chromium hydroxide, carbon black, calamine, etc.

(18) Ultraviolet absorbing / blocking agent Benzophenone derivative (2-hydroxy-4-methoxybenzophenone, 2-hydroxy-4-methoxybenzophenone-
5-sulfonic acid, sodium 2-hydroxy-4-methoxybenzophenone-5-sulfonate, dihydroxydimethoxybenzophenone, sodium dihydroxydimethoxybenzophenone-sulfonate, 2,4-dihydroxybenzophenone, tetrahydroxybenzophenone, etc.), para-aminobenzoic acid derivative ( Paraaminobenzoic acid, ethyl paraaminobenzoate, glyceryl paraaminobenzoate, amyl paradimethylaminobenzoate, octyl paradimethylaminobenzoate, etc., methoxycinnamic acid derivatives (ethyl paramethoxycinnamate, isopropyl paramethoxycinnamate,
Octyl paramethoxycinnamate, 2-ethoxyethyl paramethoxycinnamate, sodium paramethoxycinnamate, potassium paramethoxycinnamate, mono-2-diparamethoxycinnamate
Glyceryl ethylhexanoate, etc.), salicylic acid derivatives (octyl salicylate, phenyl salicylate, homomenthyl salicylate, dipropylene glycol salicylate,
Ethylene glycol salicylate, myristyl salicylate, methyl salicylate, etc.), anthranilic acid derivatives (methyl anthranilate, etc.), urocanic acid derivatives (urocanic acid, ethyl urocanate, etc.), coumarin derivatives, amino acid compounds, benzotriazole derivatives, tetrazole derivatives, imidazoline Derivative, pyrimidine derivative,
Dioxane derivative, camphor derivative, furan derivative,
Pyrone derivative, nucleic acid derivative, allantoin derivative, nicotinic acid derivative, vitamin B6 derivative, umbelliferone, esculin, benzyl cinnamate, cinoxate, oxybenzone, dioxybenzone, octabenzone, thrisobenzone, benzoresorcinol, arbutin, guaiazulene, shikonin, baicalin, Baicalein, berberine, neoheliopan, escarol, zinc oxide,
Talc, kaolin, etc.

(19) Whitening agent Para-aminobenzoic acid derivative, salicylic acid derivative, anthranilic acid derivative, coumarin derivative, amino acid compound,
Benzotriazole derivative, tetrazole derivative, imidazoline derivative, pyrimidine derivative, dioxane derivative, camphor derivative, furan derivative, pyrone derivative,
Nucleic acid derivative, allantoin derivative, nicotinic acid derivative,
Vitamin C or its derivatives (vitamin C phosphate magnesium salt, vitamin C glucoside, etc.), vitamin E or its derivatives, kojic acid or its derivatives, oxybenzone, benzophenone, arbutin, guaiazulene, shikonin, baicalin, baicalein, berberine, placenta extract. , Ellagic acid, lucinol, etc.

(20) Tyrosinase activity inhibitor Vitamin C or its derivative (vitamin C phosphate magnesium salt, vitamin C glucoside etc.), hydroquinone or its derivative (hydroquinone benzyl ether etc.), kojic acid or its derivative, vitamin E or Derivatives thereof, N-acetyltyrosine or a derivative thereof, glutathione, hydrogen peroxide, zinc peroxide, placenta extract, ellagic acid, arbutin, rucinol, silk extract, plant extract (chamomile, mulberry, gardenia, touki, waremokou,
Clara, mugwort, honeysuckle, yellowfin, duckweed, matsuhod, pearl barley, duckweed, hops, hawthorn, eucalyptus, yarrow, altea, keihi, mankaishi, hamarisu, yamagwa, extended life grass, bellflower, horsetail, succulent, yellow-dried, hemp dry, hemp. Senkyu, dokkatsu, psycho, bow hu, hama boufu, sardine, peony skin, peony, genosho, kakkon, licorice, quintuplet, aloe, shouma, safflower, green tea, black tea, assen drug) etc.

(21) Melanin dye reducing / decomposing substance Phenylmercury hexachlorophene, mercuric oxide, mercuric chloride, hydrogen peroxide solution, zinc peroxide, hydroquinone or its derivative (hydroquinone benzyl ether)
etc.

(22) Turnover promoting action / cell activating substance Hydroquinone, lactic acid bacterium extract, placenta extract, ganoderma lucidum extract, vitamin A, vitamin E, allantoin, spleen extract, thymus extract, yeast extract, fermented milk extract, plant extract (Aloe, dragonfly, horsetail, gentian, burdock,
Sikon, carrot, hamamelis, hop, yokinin,
Odori Koso, Assemblies, Touki, Daffodil, Amacha, Hypericum, Cucumber, Prickly Pear,
Rosemary, parsley) etc.

(23) Astringent succinic acid, allantoin, zinc chloride, zinc sulfate, zinc oxide, calamine, zinc paraphenolsulfonate, potassium aluminum sulfate, resorcin, ferric chloride, tannic acid (including catechin compound), etc. .

(24) Active oxygen scavenger SOD, catalase, glutathione peroxidase, etc.

(25) Antioxidant Vitamin C or salt thereof, stearic acid ester, vitamin E or derivative thereof, nordihydroguaselethenoic acid, butylhydroxytoluene (BHT), butylhydroxyanisole (BHA), hydroxytyrosol, Parahydroxyanisole, propyl gallate, sesamol,
Sesamorin, Gossypol, Propolis etc.

(26) Lipid peroxide production inhibitor β-carotene, plant extract (sesame cultured cells, armature,
Hypericum perforatum, Hamamelis, Clove, Melissa, Trillium birch, Salvia, Rosemary, South Tenmi, Ages, Ginkgo, green tea) etc.

(27) Anti-inflammatory agent Ictamol, indomethacin, kaolin, salicylic acid, sodium salicylate, methyl salicylate, acetylsalicylic acid, diphenhydramine hydrochloride, d-camphor,
dl-camphor, hydrocortisone, guaiazulene, chamazulen, chlorpheniramine maleate, glycyrrhizic acid or its salt, glycyrrhetinic acid or its salt, licorice extract, shikon extract, agets extract, propolis and the like.

(28) Antibacterial / bactericidal / disinfectant Acrinol, sulfur, calcium gluconate, chlorhexidine gluconate, sulfamine, mercury chrome, lactoferrin or its hydrolyzate, alkyldiaminoethylglycine chloride solution, triclosan, sodium hypochlorite, Chloramine T, porridge powder, iodine compound,
Iodoform, sorbic acid or its salt, propionic acid or its salt, salicylic acid, dehydroacetic acid, parahydroxybenzoic acid esters, undecylenic acid, thiamine lauryl sulfate, thiamine lauryl nitrate, phenol, cresol, p-chlorophenol, p- Chloro-m-xylenol, p-chloro-m-cresol, thymol, phenethyl alcohol, O-phenylphenol, Irgasan CH3565,
Halocarbane, hexachlorophen, chlorohexidine, ethanol, methanol, isopropyl alcohol, benzyl alcohol, ethylene glycol, propylene glycol, 2-phenoxyethanol, 1,2-pentanediol, zinc pyridione, chlorobutanol, isopropylmethylphenol, nonionic surfactant Agents (polyoxyethylene lauryl ether, polyoxyethylene nonylphenyl ether, polyoxyethylene octylphenyl ether, etc.), amphoteric surfactants, anionic surfactants (sodium lauryl sulfate, lauroyl sarcosine potassium, etc.), cationic surfactants (odor Trimethylammonium chloride, benzalkonium chloride, benzethonium chloride, methylrosaniline chloride), formaldehyde, hexamine, yellowtail Ant Green, Malachite Green, Crystal Violet, Jermal, Photosensitizer No. 101, Photosensitizer No. 201, Photosensitizer No. 401, N-long chain acyl basic amino acid derivative and its acid addition salt, zinc oxide, hinokitiol, kujin, propolis, etc. .

(29) Humectant Glycerin, propylene glycol, 1,3-butylene glycol, hyaluronic acid or its salt, polyethylene glycol, chondroitin sulfate or its salt, water-soluble chitin or its derivative or chitosan derivative, pyrrolidonecarboxylic acid or its Salt, sodium lactate, mini-sasaniki extract, Bacillus natto metabolite, natto extract, loofah water, birch (white birch) or sap of red pine

(30) Elastase activity inhibitor diisopropyl fluorophosphate, plant extract (salmon, hypericum, clara, mulberry leaf, cinnamon, ginger ginger, comfrey, salvia, elderberry, bodige, button pipi), seaweed extract and the like.

(31) Hair agent Selenium disulfide, alkylisoquinolinium bromide solution, zinc pyrithione, biphenamine, thiantol, castal tincture, ginger tincture, capsicum tincture, quinine hydrochloride, strong aqueous ammonia, potassium bromate, bromate Sodium, thioglycolic acid, etc.

(32) Antiandrogen agent Estrogen (estron, estradiol, ethinyl estradiol, etc.), isoflavone, oxendron, etc.

(33) Peripheral blood flow promoter Vitamin E or a derivative thereof, cucumber extract, garlic extract, ginseng extract, aloe extract, gentian extract, touki extract, cepharanthin, carpronium chloride, minoxidil and the like.

(34) Stimulants Capsicum tincture, nonyl acid vanilamide, cantharis tincture, ginger tincture, peppermint oil, l-menthol, camphor, benzyl nicotinate and the like.

(35) Metabolism activator Photosensitizer No. 301, hinokitiol, pantothenic acid or its derivatives, allantoin, placenta extract, biotin, pentadecanoic acid glyceride, etc.

(36) Antiseborrheic agent pyridoxine or its derivative, sulfur, vitamin B6
etc.

(37) Keratolytic agent Resorcin, salicylic acid, lactic acid, urea, etc.

(38) Oxidizing agent Hydrogen peroxide water, sodium persulfate, ammonium persulfate, sodium perborate, urea peroxide, sodium percarbonate, sodium tripolyphosphate peroxide, sodium bromate, potassium bromate, pyroline peroxide Sodium phosphate, sodium peroxyorthophosphate, sodium silicate hydrogen peroxide adduct, sodium sulfate hydrogen peroxide adduct, sodium chloride hydrogen peroxide adduct, β-tyrosinase enzyme solution,
Mushroom extract, etc.

(39) Hair remover Strontium sulfate, sodium sulfide, barium sulfide,
Inorganic reducing agents such as calcium sulfide, thioglycolic acid or salts thereof (calcium thioglycolate, sodium thioglycolate, lithium thioglycolate, magnesium thioglycolate, strontium thioglycolate) and the like.

(40) Hair swelling agent Ethanolamine, urea, guanidine, etc.

(41) Dyeing agent 5-aminoorthocresol, 2-amino-4-nitrophenol, 2-amino-5-nitrophenol, 1-amino-4-methylaminoanthraquinone, 3,3'-iminodiphenol ,
2,4-diaminophenoxyethanol hydrochloride, 2,4-diaminophenol hydrochloride, toluene-2,5-diamine hydrochloride, nitroparaphenylenediamine hydrochloride, paraphenylenediamine hydrochloride, N-phenylparaphenylenediamine hydrochloride, metaphenylenediamine hydrochloride, ortho Aminophenol, N-phenylparaphenylenediamine acetate, 1,4-diaminoanthraquinone, 2,6-diaminopyridine, 1,5-dihydroxynaphthalene, toluene-2,5-diamine, toluene-3,4-
Diamine, nitroparaphenylenediamine, paraaminophenol, paranitroorthophenylenediamine, paraphenylenediamine, paramethylaminophenol,
Picramic acid, sodium picramate, N, N'-bis (4-aminophenyl) -2,5-diamino-1,4-quinonediimine, 5- (2-hydroxyethylamino) -2-methylphenol, N-phenyl Paraphenylenediamine, metaaminophenol, metaphenylenediamine, 5-aminoorthocresol sulfate, 2-amino-5-nitrophenol sulfate,
Orthoaminophenol sulfate, orthochloroparaphenylenediamine sulfate, 4,4'-diaminodiphenylamine sulfate, 2,4-diaminophenol sulfate, toluene-2,5-sulfate
Diamine, nitroparaphenylenediamine sulfate, paraaminophenol sulfate, paranitroorthophenylenediamine sulfate, paranitrometaphenylenediamine sulfate, paraphenylenediamine sulfate, paramethylaminophenol sulfate, metaaminophenol sulfate, metaphenylenediamine sulfate, catechol, diphenylamine , Α-naphthol, hydroquinone, pyrogallol, phloroglucin, gallic acid, resorcin, tannic acid, 2-hydroxy
-5-Nitro-2 ', 4'-diaminoazobenzene-5'-sodium sulfonate, hematein, etc.

(42) Fragrances Natural animal fragrances such as musk, civet, catrium, ambergris, anise essential oil, angelica essential oil, ylang-ylang essential oil, iris essential oil, fennel essential oil, orange essential oil, cananga essential oil, karaway essential oil, cardamom essential oil, Guayakwood essential oil, cumin essential oil, black character essential oil, cinnamon essential oil, ginnamon essential oil, geranium essential oil, copaiba balsam essential oil, coriandel essential oil, perilla essential oil, cedarwood essential oil, citronella essential oil, jasmine essential oil, ginger grass essential oil, cedar essential oil, spearmint essential oil, western Mint essential oil, large scented essential oil, tuberose essential oil, clove essential oil, orange essential oil, winter green essential oil, true balsam essential oil, butchery essential oil, rose essential oil, palmarosa essential oil, cypress essential oil, hiba essential oil,
Sandalwood essential oil, petitgrain essential oil, bay essential oil, vetiver essential oil, bergamot essential oil, Peruvian balsam essential oil, boad rose essential oil, scented essential oil, mandarin essential oil, eucalyptus essential oil, lime essential oil, lavender essential oil, linaloe essential oil, lemongrass essential oil, lemon essential oil, rosemary Vegetable oils such as essential oils and Japanese peppermint oil, and other synthetic flavors.

(43) Dye / Colorant Red cabbage dye, red rice dye, madder dye, annatto dye, squid dye, turmeric dye, ende dye, krill dye, persimmon dye, caramel, gold, silver, gardenia dye, corn dye , Onion pigment, tamarind pigment, spirulina pigment, whole buckwheat pigment, cherry pigment, laver pigment, hibiscus pigment, grape juice pigment, marigold pigment, purple potato pigment, purple yam pigment, lac pigment, rutin, etc.

(44) Sweetener Sugar, sweet tea, fructose, arabinose, galactose, xylose, stevia, mannose, maltose, honey, glucose, miraculin, monerin, licorice extract and the like.

(45) Nutrient enhancer Calcined shellfish calcium, cyanocholamine, yeast, wheat germ, egg yolk powder, hemicellulose, heme iron and the like.

(46) Dairy products Milk, cheese, fresh cream, butter, margarine, powdered milk, whey, condensed milk, etc.

(44) Other hormones, sequestering agents, pH adjusting agents, chelating agents, antiseptic / antifungal agents, cooling agents, stabilizers, emulsifiers, kinetic agents
Vegetable protein and its degradation product, animal / vegetable polysaccharide and its degradation product, animal / vegetable glycoprotein and its degradation product, blood flow promoter, anti-inflammatory / anti-inflammatory / anti-allergic agent, wound healing agent, Foaming agents, thickening agents, enzymes, purified water (electronic water, small clusters, etc.), oral agents, deodorizing / deodorizing agents, bitters, seasonings, etc. are listed. An additive or synergistic improvement of the invention effect or other cosmetic effect can be expected.

The moisturizing agent, skin anti-aging agent, anti-inflammatory agent, cosmetic composition or food and drink of the present invention may be added in advance or may be added during the production. It may be selected as appropriate in consideration of workability.

[0094]

EXAMPLES The present invention will be described below with reference to production examples, test examples, and formulation examples, but the present invention is not limited thereto.

(Production Example 1) Silk protein degradation product was silk (100 g)
First, raise the temperature to 80 ° C or higher and sterilize by heating. This is heated and dissolved in a high-concentration salt solution of lithium bromide, magnesium nitrate, and calcium chloride, then desalted by dialysis, reverse osmosis, etc., and then treated with a protease. The protease used was trypsin at a ratio of 1 part to 40 parts of silk at 37 ° C, p
Operate under the condition of H7.0. At that time, it decomposes aseptically over 24 hours. After that, the temperature is raised to 80 ° C. or higher to inactivate the enzyme, and the precipitate is removed by centrifugation to obtain a decomposed product derived from silk protein. This is spray-dried to obtain about 10 to 30 g of powder.

(Production Example 2) The keratin protein degradation product was prepared by adding 100 L of hydrochloric acid to 100 g of feathers, treating at 100 ° C. for 15 hours, neutralizing with sodium hydroxide, desalting, spray-drying and powdering. About 10 to 30 g.

(Production Example 3) The collagen protein degradation product was
After washing pig skin tissue (100 g) with water, purified water is added and treated with enzyme bromelain to purify, and the temperature is raised to 80 ° C. or higher to sterilize by heating. Then, it is purified and filtered, and about 10 to 30 g of powder is obtained by spray drying.

(Production Example 4) Various dried plants of Triticum perforatum, Hypericum perforatum, Salvia, Bodaiju, and Rakanka 10
0 g of the extract is heated and extracted with purified water (about 80 ° C.) for about 5 hours and filtered to obtain about 1.0 kg of extract (dry solid content: about 0.1 to 2.5%).

(Production Example 5) Various dried plants 10 of Trillium longiflorum, Hypericum perforatum, Salvia, Bodaiju, and Rakanka 10
Soak 0 g in 50% ethanol solution, extract at room temperature for 5 days and then filter and extract (dry solids: about 0.1-2.5%)
About 1.0 kg.

(Production Example 6) Various dried plants of Trillium perforatum, Hypericum perforatum, Salvia, Bodaiju, and Rakanka 10
Soak 0g in 70% ethanol solution, 70% 1,3-butylene glycol solution, 60% propylene glycol solution, or purified water (about 30 ℃), extract at room temperature for 5 days and then extract by filtration. (Dry solids: about 0.1-3.0%) about 1.0 kg
obtain.

(Test 1) Skin Moisturization Test 1 (Test Method) For 10 healthy women aged 20 to 28 years, the amount of the active ingredient of the sample was about 8700 mg / day (1 bottle), and the amount was 16 times daily. I had him drink it before going to bed every day. (Sample) Silk protein degradation product of Production Example 1, Keratin protein degradation product of Production Example 2, Collagen protein degradation product of Production Example 3,
Further, each of the proteolytic products of Production Examples 1, 2, and 3 was mixed with purified plant water alone or the same amount of various plant extract solutions of Production Example 4 was dissolved in purified water to prepare a sweetener and a sour taste. Beauty drinks with appropriate amounts of ingredients, flavors and preservatives were used in the test. (Evaluation method) On the 17th day after the test disclosure, in order to evaluate the moisturizing property of the skin, the skin of the subject's lower eyelid (under the eye) was SKICON.
-200 (purchased from IBS Co., Ltd.) was used to increase the stratum corneum water content to 2
Measured twice. The average value of each test group was calculated and evaluated. The results are shown in Tables 1 and 2 (the higher the stratum corneum water content, the higher the moisturizing property of the skin). No one complained of any abnormality during the period of use.

[0102]

[Table 1]

(Test Results) As shown in Table 1, it was confirmed that the silk protein degradation product, keratin protein degradation product and collagen protein degradation product of the present invention had a higher skin horny layer water content than the control group. Was done. Therefore, it was confirmed that it has a moisturizing effect.

[0104]

[Table 2]

(Test Results) As shown in Table 2, one or more kinds of proteolytic products selected from the proteolytic product of silk protein, the proteolytic product of keratin and the proteolytic product of collagen according to the present invention were further added to Trichophyllum japonicum, Hypericum perforatum, Salvia, Bodaiju, Those containing one or more kinds of plant extracts selected from Rakanka have a higher keratin water content in the skin than the case of using silk protein degradation product, keratin protein degradation product, collagen protein degradation product alone. It was confirmed that many of them showed a synergistic effect. Therefore, it was confirmed that it has a moisturizing effect.

(Test 2) Skin Moisturization Test 2 (Test Method) For 10 healthy women aged 20 to 28 years, the amount of the active ingredient of the sample was about 8700 mg / day (1 bottle), and the amount was 16 times daily. I had him drink it before going to bed every day. (Sample) Silk protein degradation product of Production Example 1, Keratin protein degradation product of Production Example 2, Collagen protein degradation product of Production Example 3,
Further, each of the proteolytic products of Production Examples 1, 2, and 3 was mixed with purified plant water alone or the same amount of various plant extract solutions of Production Example 4 was dissolved in purified water to prepare a sweetener and a sour taste. Beauty drinks with appropriate amounts of ingredients, flavors and preservatives were used in the test. (Evaluation method) On the 17th day after the test disclosure, in order to evaluate the moisturizing property of the skin, the skin of the lower eyelid (under the eyes) of the subject was TEWAMEed.
The transepidermal water loss (water evaporation) was measured twice using TER TM 210 (purchased from Integral Co., Ltd.). The average value of each test group was calculated and evaluated. The results are shown in Tables 3-4.
(The lower the amount of water evaporation, the higher the moisture retention of the skin). No one complained of any abnormality during the period of use.

[0107]

[Table 3]

(Test Results) As shown in Table 3, it was confirmed that the silk protein degradation product, the keratin protein degradation product and the collagen protein degradation product of the present invention had a smaller amount of skin water loss than the control group. . Therefore, it was confirmed that transpiration of water related to moisturization is prevented.

[0109]

[Table 4]

(Test Results) As shown in Table 4, one or more kinds of proteolytic products selected from the silk proteolytic product, keratin proteolytic product and collagen proteolytic product of the present invention were further added, and Pleurotus cornucopiae L., Hypericum, Salvia, Bodaiju, Those containing one or more kinds of plant extracts selected from Rakanka have a smaller amount of water evaporation of the skin, as compared with the case where the silk protein decomposed product, the keratin protein decomposed product, and the collagen protein decomposed product are used alone. It was confirmed to show a synergistic effect. Therefore, it was confirmed that transpiration of water related to moisturization is prevented.

(Test 3) Skin Elasticity Test (Test Method) For 10 healthy women aged 20 to 28, the amount of the active ingredient of the sample was about 8700 mg / day (1 bottle), and the amount was 16 days every day. I had it taken before bed. (Sample) Silk protein degradation product of Production Example 1, Keratin protein degradation product of Production Example 2, Collagen protein degradation product of Production Example 3,
Further, each of the proteolytic products of Production Examples 1, 2, and 3 was mixed with purified plant water alone or the same amount of various plant extract solutions of Production Example 4 was dissolved in purified water to prepare a sweetener and a sour taste. Beauty drinks with appropriate amounts of ingredients, flavors and preservatives were used in the test. (Evaluation method) On the 17th day after the test disclosure, in order to evaluate the elasticity of the skin, the skin of the subject's lower eyelid (under the eye) was cut by CUTOME.
Elasticity and plasticity were measured using TER SEM474 (purchased from Integral Co., Ltd.). The measurement conditions were mode 1, mode 5 seconds, and an operation of applying a negative pressure of 500 mb for 5 seconds was repeated twice. The average value of each test group was calculated and evaluated.
The results are shown in Tables 5 and 6 to 7 (the higher the elasticity, the higher the elasticity of the skin, and the lower the plasticity, the higher the elasticity of the skin). No one complained of any abnormality during the period of use.

[0112]

[Table 5]

(Test Results) As shown in Table 5, the silk protein degradation product, keratin protein degradation product and collagen protein degradation product of the present invention have higher elasticity and lower plasticity than the control group. From this, it was confirmed that the reduction of elasticity of the skin was prevented and improved. Therefore, it can be used as a skin anti-aging agent.

[0114]

[Table 6]

[0115]

[Table 7]

(Test Results) As shown in Tables 6 to 7, one or more kinds of protein degradation products selected from the silk protein degradation product, the keratin protein degradation product and the collagen protein degradation product of the present invention were further added. Bodaiju,
Those containing one or more kinds of plant extracts selected from Rakanka are compared with the case where silk protein degradation product, keratin protein degradation product, collagen protein degradation product is used alone.
Further, it was confirmed that the elasticity is high and the plasticity is low, and therefore a synergistic effect is exhibited. Therefore, it can be used as a skin anti-aging agent.

(Test 4) Skin anti-inflammatory test (Test method) BALB / c mice, female, and 7-week-old were purchased from Japan SLC, Inc. and used for a 1-week acclimation post-breeding test. The hair of the back of the animal is shaved with an animal hair clipper and shaver, and the active ingredient of the sample is about 174 mg / kg / day once a day for 8 days.
It was prepared daily and orally administered. On day 4 of administration, 25 mJ / cm ² of ultraviolet rays (FL20S · E lamp manufactured by Toshiba) was applied to the shaved back skin. (Sample) Silk protein degradation product of Production Example 1, Keratin protein degradation product of Production Example 2, Collagen protein degradation product of Production Example 3,
Further, each of the proteolytic products of Production Examples 1, 2, and 3 was mixed with purified neem extract extract of Production Example 4 alone or an equal amount of various plant extract solutions of Production Example 4 with dissolved purified water. (Judgment method) For judgment, MEXAMETER MX 18 (purchased from Integral Co., Ltd.) was used to measure the erythema degree of the back skin from immediately before ultraviolet rays to the end of the test. As a control, a group was prepared in which only purified water was administered, and the test groups were combined with 5 animals in each group for a total of 3 groups. The control group was given the same amount of liquid as the sample administration group. The results are shown in FIGS.

(Test Results) As shown in FIG. 1, it was confirmed that the silk protein degradation product, keratin protein degradation product and collagen protein degradation product of the present invention suppressed erythema of the skin as compared with the control group. Therefore, it was confirmed to have an anti-inflammatory effect.

(Test Results) As shown in FIGS. 2 to 4, one or more protein degradation products selected from the silk protein degradation product, the keratin protein degradation product, and the collagen protein degradation product of the present invention were further added to the Phellinus linteus plant extract or the Phellinus linteus. , St. John's wort, Salvia, Bodaiju, those containing an equal amount mixture of each extract of swingle, silk protein degradation product, keratin protein degradation product, compared to the case of using collagen protein degradation product alone, further erythema of the skin It was confirmed to suppress. Therefore, it was confirmed to have an anti-inflammatory effect. In addition, one or more proteolytic products selected from the proteolytic product of silk protein, the proteolytic product of keratin, and the proteolytic product of collagen of the present invention may further contain extracts of Hypericum perforatum, Salvia, Bodige, and Rakanka alone. Similar results were obtained.

(Test 5) Safety test (1) Primary skin irritation test Various protein degradation products or various plant extracts obtained in Production Examples 1 to 6 were prepared so that the solid content concentration was about 2.0%. , This is a Hartley guinea pig with a shaved back (female, 1
3 × group, weight 300-350g) per square of 2 × 2cm ² of skin
0.03 mL each was applied. Judgment was performed 24, 48, and 72 hours after application by the primary irritation scoring method using erythema and edema as indexes. As a result, in all animals, no erythema or edema was observed, and it was determined to be negative.

(Test 6) Safety test (2) Skin cumulative irritation test Various protein degradation products or various plant extracts obtained in Production Examples 1 to 6 were prepared so that the solid content concentration was about 2.0%. , 1 day a day on the skin of a Hartley guinea pig (female, 3 animals per group, weighing about 320 g) whose flanks were shaved (2 × 4 cm ² ).
0.5 mL / per animal, 5 times a week. The application was carried out for 2 weeks, and the shearing was performed on the last application day of each week. Judgment was performed on the day after each application day and the day after the last application day, using erythema and edema as indexes by the primary irritation scoring method. As a result, all the animals were judged to be negative because no erythema or edema was observed for 2 weeks after application.

(Test 7) Safety test (3) Single dose toxicity test The various protein degradation products or various plant extracts obtained in Production Examples 1 to 6 were adjusted with purified water to a concentration of 12.5%, 16 mL / kg per animal was orally administered to ddy mice (male and female, 5 mice per group, 5 weeks old) that had been fasted for 16 hours before the test, with the onset of toxicity symptoms, etc. Was observed over time. As a result, in all mice for 14 days,
No abnormalities were observed, and the anatomy results were also normal. Therefore, the LD ₅₀ was 2,000 mg / kg or more, and the substance was judged to be safe.

(Prescription example) Production of moisturizing agent, skin anti-aging agent, anti-inflammatory agent, cosmetic composition or food and drink In accordance with the above-mentioned evaluation results, the prescription example will be shown below. What was manufactured by the usual method in manufacture was sufficient, and only the compounding quantity was shown. Further, the present invention is not limited to these.

[0124] (Prescription example 1) Emulsion mass%     1. Squalane 8.0     2. Jojoba oil 7.0     3. Cetyl alcohol 1.5     4. Glycerin monostearate 2.0     5. Polyoxyethylene (20) cetyl ether 3.0     6. Polyoxyethylene (20) soorbitan monooleate 2.0     7.1,3-butylene glycol 1.0     8. Glycerin 2.0     9.A: Silk protein hydrolyzate powder of Production Example 1       B: Keratin protein degradation product powder of Production Example 2       C: Collagen protein degradation product powder of Production Example 3       * Powder 3.0 of any one of A to C    10.A: Ethanol extract 50% ethanol extract       B: 50% ethanol extract of Hypericum perforatum       C: Salvia whole plant 50% ethanol extract       D: Bodaiju whole plant 50% ethanol extract       E: 50% ethanol extract of whole citrus plant       * Any one of A to E extract 3.0    11. Preservative (paraoxybenzoate) Suitable amount    12. Perfume proper amount    13. Residue to make purified water 100

[0125] (Prescription example 2) Emulsion mass%     1. Squalane 8.0     2. Jojoba oil 7.0     3. Glyceryl p-aminobenzoate 1.0     4. Ethyl urocanate 1.0     5. Vitamin C phosphate magnesium salt 1.0     6. Cetyl alcohol 1.5     7. Glycerin monostearate 2.0     8. Polyoxyethylene (20) cetyl ether 3.0     9. Polyoxyethylene (20) soorbitan monooleate 2.0    10.1,2-Pentanediol 1.0    11. Glycerin 2.0    12. Silk protein enzymatic degradation solution 5.0    13. Crassulaceae whole plant 70% ethanol extract 5.0    14. Pig placenta water extract 1.0    15. Preservative (paraoxybenzoate) Suitable amount    16. Residue to make purified water 100

[0126] (Prescription example 3) Cosmetic oil mass%     1. Liquid paraffin 30.0     2. Squalane 20.0     3. Olive oil 10.0     4. Isopropyl palmitate 10.0     5. Olive oil 1.0     6. Shea butter 1.0     7. Butylhydroxyanisole 0.1     8. Vitamin E derivative 0.1     9. Silk protein acid decomposition solution 2.0    10. Keratin protein acid degradation solution 2.0    11. Collagen protein acid degradation solution 2.0    12. St. John's wort 50% 1,3-butylene glycol extract 1.0    13. Choji bud hot water extract 1.0    14. Grapefruit fruit or leaf hot water extract 1.0    15. Soybean seed hot water extract 1.0    16. Preservative (benzalkonium chloride)    17. Perfume (Rose water) Suitable amount    18. Residue to make purified water 100

[0127] (Formulation Example 4) Flexible lotion mass%     1. Glycerin 5.0     2.1,3-butylene glycol 5.0     3. Polyoxyethylene sorbitan monolaurate (20E.O) 1.0     4. Ethanol 15.0     5. Collagen protein enzymatic degradation solution 3.0     6. Bodaiju flower or fruit 50% 1,3-butylene glycol extract 5.0     7. White birch sap 1.0     8. Antibacterial and antiseptic (lactoferrin solution)     9. Perfume (Western light water) Suitable amount    10. Preservative (paraoxybenzoate) Suitable amount    11. Residue to make purified water 100

[0128] (Prescription example 5) Astringent lotion mass%     1. Sorbit 2.0     2.POE (20) oleyl alcohol 1.0     3. Ethanol 15.0     4. Keratin protein acid degradation solution 3.0     5. Salvia flowers or leaves 50% propylene glycol extract 2.0     6. St. John's wort 50% 1,3-butylene glycol extract 2.0     7. Green tea leaf or stem 50% 1,3-butylene glycol extract 1.0     8. Hamamelis leaf or bark 50% 1,3-butylene glycol extract 1.0     9. Allantoin 0.2    10. Astringent (zinc sulfocarbonate) 0.2    11. Antibacterial / antiseptic agent (thiamin lauryl sulfate)    12. Perfume (Lavender water) Suitable amount    13. Residue to make purified water 100

[0129] (Prescription example 6) Two-layer type lotion (liquid-liquid type) mass%     1. Squalane 8.0     2. POE sorbitan tetraoleate 0.3     3. Solbit 1.0     4. Ethanol 15.0     5. Silk protein enzymatic degradation solution 3.0     6. Salvia whole plant 30% ethanol extract 2.0     7. Bodaiju flower or fruit 30% ethanol extract 1.0     8. Panax ginseng rhizome 30% ethanol extract 1.0     9. Whole plant 50% 1,3-butylene glycol extract 1.0    10. Ascorbic acid 0.2    11. Astringent (calamine) 0.1    12. Preservative (phenoxyethanol) Suitable amount    13. Perfume (apple water)    14. Purified water 100 residue

[0130] (Prescription example 7) Carmine lotion (liquid to solid) mass%     1. Glycerin 3.0     2.1,3-butylene glycol 5.0     3. Ethanol 15.0     4. Iron oxide (red iron oxide) 0.2     5. Zinc oxide 0.5     6. Kaolin 2.0     7. Silk protein alkaline solution 2.0     8. Keratin protein alkaline decomposition solution 2.0     9. Collagen protein alkaline decomposition solution 2.0    10. St. John's wort 50% propylene glycol extract 2.0    11. Comfrey leaf and stem 50% ethanol extract 1.0    12. Hamamelis leaf or bark 50% propylene glycol extract 1.0    13. Pig placenta enzyme decomposition solution 1.0    14. Camphor 0.2    15. Phenol 0.03    16. Preservative (photosensitive element 201 & 401)    17. Fragrance (lemon water) Suitable amount    18. Residue to make purified water 100

[0131] (Prescription example 8) Pack mass%     1. Polyvinyl alcohol 15.0     2. Carboxymethyl cellulose sodium 5.0     3. Propylene glycol 3.0     4. Ethanol 15.0     5. Silk protein enzymatic degradation solution 3.0     6. Keratin protein enzymatic degradation solution 3.0     7. Collagen protein enzymatic degradation solution 3.0     8. Bodaiju whole plant 50% glycerin extract 2.0     9. Cornflower 50% diglycerin extract 2.0    10. Peach leaf hot water extract 2.0    11. Preservative (paraoxybenzoate) Suitable amount    12. Perfume (Ylang-Ylang essential oil) Suitable amount    13. Residue to make purified water 100

[0132] (Prescription example 9) Peel-off pack mass%     1. Glycerin 6.0     2. Propylene glycol 4.0     3. Polyvinyl alcohol 15.0     4. Ethanol 10.0     5. Polyoxyethylene glycol 1.0     6. Pantothenyl ethyl ether 1.0     7. Keratin protein acid degradation solution 3.0     8. Collagen protein enzymatic degradation solution 3.0     9. Rakanka whole plant 50% ethanol extract 2.0    10. Enzosou whole grass 50% ethanol extract 2.0    11. Eucalyptus leaf or stem 30% ethanol extract 2.0    12. Safflower whole plant 50% ethanol extract 2.0    13. Arnica flower or leaf 30% ethanol extract 2.0    14. Trehalose solution 1.0    15. Preservative (paraoxybenzoate) Suitable amount    16. Perfume (Chamomile water) Suitable amount    17. Residue to make purified water 100

[0133] (Prescription example 10) Cold cream mass%     1. White beeswax 11.0     2. Liquid paraffin 22.0     3. Lanolin 10.0     4. Olive oil 5.0     5. Chamomile oil 5.0     6. Palm oil 5.0     7. Borax 0.5     8. Keratin protein enzymatic degradation solution 3.0     9. Salvia whole plant extract 3.0       (Ethanol: 1,3-butylene glycol = 1: 1 extraction solvent)    10. Rakanka whole plant extract 3.0       (Ethanol: 1,3-butylene glycol = 1: 1 extraction solvent)    11. Yuzu fruit extract 2.0       (Ethanol: 1,3-butylene glycol = 1: 1 extraction solvent)    12. White birch bark extract 2.0       (Ethanol: 1,3-butylene glycol = 1: 1 extraction solvent)    13. Soybean seed water extract 1.0    14. Liquid shea fat 1.0    15. Dipotassium glycyrrhizinate 0.1    16. Preservative (acrinol) 0.1    17. Fragrance (lavender water) Suitable amount    18. Residue to make purified water 100

[0134] (Formulation example 11) Emollient cream mass%     1. Stearic acid 2.0     2. Stearyl alcohol 7.0     3. Reduced lanolin 2.0     4. Squalane 5.0     5. Octyldodecanol 6.0     6. Polyoxyethylene cetyl ether (25E.O.) 3.0     7. Lipophilic glyceryl monostearate 2.0     8. Propylene glycol 5.0     9.1,2-Pentanediol 2.0    10. Silk protein enzymatic degradation solution 3.0    11. Trillium leaf or stem hot water extract 2.0    12. Bodaiju bark hot water extract 2.0    13. Shiso leaf 50% propylene glycol extract 2.0    14. Purple root 50% propylene glycol extract 2.0    15. Soybean seed fermented soybeans 1.0    16. Glycyrrhetinic acid 0.1    17. Pig placenta enzyme digestion solution 0.5    18. Preservative (paraben) Suitable amount    19. Perfume (clove water) appropriate amount    20. Residue of purified water 100

[0135] (Prescription example 12) Face wash cream Mass%     1. Myristic acid 25.0     2. Stearic acid 15.0     3. Beef tallow fatty acid 5.0     4. Propylene glycol 10.0     5. Potassium hydroxide 6.0     6. Coconut oil fatty acid diethanolamide 6.0     7. Collagen protein alkaline decomposition solution 3.0     8. St. John's wort 50% 1,3-butylene glycol extract 3.0     9. Carrot root 50% 50% glycerin extract 3.0    10. Carrageenan 1.0    11. Dipotassium glycyrrhetinate 1.0    12.Kakkon hot water extract 2.0    13. Apricot kernel 0.1    14. Preservative (salicylic acid) 0.1    15. Perfume (oncoming water) Appropriate amount    16. Residue to make purified water 100

[0136] (Prescription example 13) Face-wash cream mass%     1. Stearic acid 15.0     2. Palmitic acid 15.0     3. Myristic acid 15.0     4. Lauric acid 4.0     5. Oleyl alcohol 1.5     6. Lanolin derivative (EO adduct) 1.0     7. Glycerin 18.0     8. Potassium hydroxide 6.0     9.A: Enzymatic solution of silk protein       B: Keratin protein enzymatic degradation solution       C: Collagen protein enzymatic degradation solution       * Any one of the decomposition solutions of A to C 3.0    10. Oil-soluble St. John's Wort extract 2.0       (Ethanol: 1,3-butylene glycol = 1: 1 extract)    11. Oil-soluble chamomile flower or leaf extract 2.0       (Ethanol: 1,3-butylene glycol = 1: 1 extract)    12. Royal Jelly Extract 1.0       (Ethanol: 1,3-butylene glycol = 1: 1 extract)    13. Glycyrrhetinic acid 1.0    14. Preservative (salicylic acid) 0.1    15. Perfume (Mugwort water) Suitable amount    16. Residue to make purified water 100

[0137] (Prescription example 14) Body soap mass%     1. Potassium laurate 15.0     2. Potassium myristate 5.0     3. Propylene glycol 5.0     4. Silk protein enzymatic degradation solution 1.0     5. Keratin protein enzymatic degradation solution 1.0     6. Collagen protein enzymatic degradation solution 1.0     7. Toki rhizome 70% 2,3-butylene glycol extract 0.5     8. Seaweed 70% 1,3-butylene glycol extract 0.5     9. Horsetail stem 70% 1,3-butylene glycol extract 1.5    10. Loquat leaf 70% 1,3-butylene glycol extract 1.5    11. Aloe pulp 70% ethanol extract 2.0    12.Hop cone 70% 1,3-butylene glycol extract 1.5    13. Polyethylene powder 0.5    14. Hydroxypropyl chitosan solution 0.5    15. Amino acids (glycine, glutamine, etc.) 0.5    16. Preservatives (undecylenic acid, phenol) Suitable amount    17. pH adjuster    18. Perfume (lavender water) Suitable amount    19. Residue to make purified water 100

[0138] (Prescription example 15) Sunscreen cosmetics (O / W type) Mass%     1. Oxybenzone 2.0     2. Octyl para methoxycinnamate 5.0     3. Squalane 10.0     4. Vaseline 5.0     5. Stearyl alcohol 3.0     6. Stearic acid 3.0     7. Glyceryl monostearate 2.0     8. Polyethyl acrylate 1.0     9.1,3-butylene glycol 6.0    10. Disodium edetate 0.1    11. Triethanolamine 1.0    12. Titanium dioxide 5.0    13. Silk protein enzymatic degradation solution 1.0    14. Collagen protein enzymatic degradation solution 1.0    15. Hypericum perforatum dipropylene glycol extract 1.5    16. White birch bark 70% dipropylene glycol extract 1.5    17.Kakkon 50% propylene glycol extract 0.5    18. Soybean seed 50% dipropylene glycol extract 1.5    19. Root root 50% dipropylene glycol extract 1.5    20. Preservative (benzyl paraoxybenzoate) Suitable amount    21. Fragrance (jasmine water) Suitable amount    22. Residue of purified water 100

[0139] (Prescription example 16) Sunscreen cosmetics (oil type) Mass%     1. Liquid paraffin 65.0     2. Ethyl paraaminobenzoate 1.0     3. Tetrahydroxybenzophenone 1.0     4. Cetyl octanoate 20.0     5. Silk protein acid decomposition solution 2.0     6. Keratin protein acid degradation solution 2.0     7. Collagen protein acid decomposition solution 2.0     8. Rakanka fruit or pericarp hot water extract 3.0     9. Sancha flower whole plant hot water extract 0.5    10. Peony root or leaf hot water extract 0.5    11. Dihydroxymethoxybenzophenone 0.2    12. Antioxidant (Butyl hydroxytoluene) Suitable amount    13. Fragrance (cornflower water) Suitable amount

[0140] (Prescription example 17) Cream foundation (O / W type) Mass%     1. Stearic acid 4.0     2. Glycerin monostearate 3.0     3. Cetanol 1.5     4.Isopropyl myristate 7.0     5. Liquid paraffin 10.0     6. White beeswax 3.0     7. Triethanolamine 1.5     8. Glycerin 3.0     9. Bentonite 1.0    10.Titanium oxide 8.0    11.2,4-Dihydroxybenzophenone 8.0    12. Kaolin 3.0    13. Talc 3.0    14. Coloring pigment (yellow iron oxide) 1.0    15. Silk protein acid or alkali decomposition solution 3.0    16. Rakanka fruit or pericarp hot water extract 3.0    17. Centella asiatica leaf or stem 50% ethylene glycol extract dry powder 0.2    18. Tomato fruit 50% ethylene glycol extract dry powder 0.2    19. Wenzhou mandarin orange peel or fruit hot water extract dry powder 0.2    20. Mackerel fruit 30% butanol extract 0.2    21. Preservative (phenoxyethanol) 0.1    22. Perfume (Rose water) Suitable amount    23. Residue to make purified water 100

[0141] (Prescription example 18) Shampoo mass%     1. Lauryl sulfate triethanolamine 5.0     2. Sodium polyoxyethylene lauryl ether sulfate 12.0     3.1,3-butylene glycol 4.0     4. Lauric acid diethanolamide 2.0     5. Disodium edetate 0.1     6. Silk protein enzymatic degradation solution 1.0     7. Keratin protein enzymatic degradation solution 1.0     8. Collagen protein enzymatic degradation solution 1.0     9. Hamamelis bark hot water extract 2.0    10. Iris flowers or rhizome 30% 1,4-butylene glycol extract 2.0    11. Toki root 30% 1,4-butylene glycol extract 1.0    12. Hydroxypropyl chitosan solution 1.0    13. Mucopolysaccharide solution 1.0    14. Dipotassium glycyrrhizinate 0.1    15. Antibacterial and antiseptic (photosensitive element 101)    16. pH adjuster    17. Perfume (sandalwood water)    18. Residue to make purified water 100

[0142] (Prescription example 19) Rinse mass%     1. Stearyl trimethyl ammonium chloride 3.0     2. cetostearyl alcohol 3.0     3. Polyoxyethylene lanolin ether 3.0     4. Propylene glycol 5.0     5.1,2-Pentanediol 2.0     6.A: Enzymatic solution of silk protein       B: Keratin protein enzymatic degradation solution       C: Collagen protein enzymatic degradation solution       * Any one of the decomposition solutions of A to C 3.0     7. St. John's wort 50% 2,3-butylene glycol extract 2.0     8. Bodaiju whole plant 50% ethylene glycol extract 2.0     9. Astragalus leaf 50% 2,3-butylene glycol extract 2.0    10. Incense fruit 30% 1,2-butylene glycol extract 2.0    11. Mulberry peel 30% 1,2-butylene glycol extract 2.0    12. Scented flower 50% 1,3-butylene glycol extract 1.0    13. Yellow rhizome 50% 1,3-butylene glycol extract 1.0    14. Soybean seed fermented soybeans 0.5    15. Hydroxyethyl chitosan solution 1.0    16. Trehalose solution 1.0    17. Perfume (grape water) Suitable amount    18. Residue to make purified water 100

[0143] (Prescription example 20) Rinse mass%     1. Stearyl trimethyl ammonium chloride 2.0     2. cetostearyl alcohol 2.0     3. Polyoxyethylene lanolin ether 3.0     4. Propylene glycol 5.0     5. Ethylene glycol 3.0     6. Silk protein enzymatic degradation solution 2.0     7. Rakanka fruit or peel 50% ethylene glycol extract 2.0     8. Bodaiju whole plant 50% ethylene glycol extract 2.0     9. Olive leaf 50% 1,2-butylene glycol extract 1.0    10. Trehalose solution 1.0    11. Antibacterial and antiseptic (benzalkonium chloride)    12. Perfume (Chamomile water) Suitable amount    13. Residue to make purified water 100

[0144]  (Formulation example 21) Hair liquid mass%     1. Ethanol 29.0     2. Polyoxypropylene butyl ether phosphoric acid 10.0     3. Polyoxypropylene monobutyl ether 5.0     4. Triethanolamine 1.0     5.A: Silk protein acid decomposition solution       B: Keratin protein acid decomposition solution       C: Collagen protein acid decomposition solution       * Any one of the decomposition solutions of A to C 3.0     6.A: Ethanol extract 50% ethanol extract       B: 50% ethanol extract of Hypericum perforatum       C: Salvia whole plant 50% ethanol extract       D: Bodaiju whole plant 50% ethanol extract       E: 50% ethanol extract of whole citrus plant       * Any one of A to E extract 3.0     7. Lily bulb hot water extract 1.0     8. Spicy (Keirin Spicy) Rhizome Hot Water Extract 1.0     9. Rice bran hot water extract 1.0    10. Carpronium chloride 0.3    11. Hinokitiol 0.5    12. Antibacterial and antiseptic (paraben, benzalkonium chloride) appropriate amount    13. Perfume (Rosehip water) Suitable amount    14. Purified water 100 residue

[0145]  (Formulation Example 22) Hair liquid mass%     1. Ethanol 29.0     2. Polyoxypropylene butyl ether phosphoric acid 10.0     3. Polyoxypropylene monobutyl ether 5.0     4. Triethanolamine 1.0     5. Trimethylene glycol 5.0     6.A: Enzymatic solution of silk protein       B: Keratin protein enzymatic degradation solution       C: Collagen protein enzymatic degradation solution       * Any one of the decomposition solutions of A to C 3.0     7.A: 50% 1,3-butylene glycol extract of Triticum aeruginosa       B: 50% 1,3-butylene glycol extract of Hypericum perforatum       C: Whole Salvia 50% 1,3-butylene glycol extract       D: Bodaiju whole plant 50% 1,3-butylene glycol extract       E: 50% 1,3-butylene glycol extract of citrus whole plant       * Any one of A to E extract 3.0     8. Lemon fruit 50% 1,3-butylene glycol extract 1.0     9. Apple fruit 30% ethanol extract 1.0    10. Wormwood 50% ethanol extract 1.0    11. Lavender whole plant 50% ethanol extract 1.0    12. Azulene 0.3    13. Antibacterial / antiseptic (paraben, benzalkonium chloride) appropriate amount    14. Purified water 100 residue

[0146] (Prescription example 23) Heartnic mass%     1.Ethanol 40.0     2. Ethyl oleate 1.0     3. Polyoxyethylene (40) hydrogenated castor oil 2.0     4.A: Silk protein alkaline solution       B: Alkaline decomposition solution of keratin protein       C: Collagen protein alkaline decomposition solution       * Any one of the decomposition solutions of A to C 3.0     5.A: 50% ethanol extract of whole grass       B: 50% ethanol extract of Hypericum perforatum       C: Salvia whole plant 50% ethanol extract       D: Bodaiju whole plant 50% ethanol extract       E: 50% ethanol extract of whole citrus plant       * Any one of A to E extract 3.0     6. Soybean seed fermented soybeans 1.0     7. Hamamelis leaf or bark hot water extract 1.0     8. Carpronium chloride 0.3     9. Pantethine solution 0.5    10. Amino acids or their derivatives 3.0     (Lysine, alanine, pyrrolidone carboxylic acid, etc.)    11. Antibacterial / antiseptic agent (paraben, benzalkonium chloride)    12. Perfume (orange water) Suitable amount    13. Residue to make purified water 100

[0147] (Prescription example 24) Hair artic mass%     1.L-menthol 0.2     2. Ethanol 32.5     3. Polyoxyethylene hydrogenated castor oil 0.5     4. Propylene glycol 5.0     5. Diphenhydramine hydrochloride 0.3     6. Silk protein acid decomposition solution 3.0     7. Whole grass 50% ethanol extract 1.0     8. St. John's wort 50% ethanol extract 1.0     9. Toki rhizome hot water extract 1.0    10. Coptis rhizome hot water extract 1.0    11. Auregon rhizome or root bark 50% ethanol extract 1.0    12. Whole corn hot water extract 1.0    13. Chicken wicker extraction solution 1.0    14. Carboxymethyl chitin solution 1.0    15. Vitamin E derivative 0.5    16. Pantethine solution 0.5    17. Antibacterial and antiseptic (paraben) 0.1    18. Perfume (sage water) appropriate amount    19. Residue to make purified water 100

[0148] (Prescription example 25) Hair growth and hair nourishing agent Mass%     1.Ethanol 60.0     2. Keratin protein enzymatic degradation solution 2.0     3. Collagen protein enzymatic degradation solution 2.0     4. Crassulaceae whole plant 50% ethanol extract 1.0     5. St. John's wort 50% dipropylene glycol extract 1.0     6. Rakanka fruit or pericarp hot water extract 3.0     7. Soybean seed 50% propylene glycol extract 5.0     8. Vitamin E derivative 0.5     9. Capsicum tincture 0.5    10. Resorcin 0.5    11. Dipotassium glycyrrhizinate 0.5    12. Carboxymethyl chitin solution 0.5    13. Pig hematin solution 0.5    14. Pig mucin solution 0.5    15. Amino acids (arginine, glycine, glutamine, etc.) 0.5    16. Antibacterial and antiseptic (paraben) 0.1    17. Perfume (rosemary water) Suitable amount    18. Residue to make purified water 100

[0149] (Prescription example 26) Hair growth and hair nourishing agent mass%     1.Ethanol 60.0     2. Keratin protein enzymatic degradation solution 2.0     3. Crassulaceae whole plant 50% ethanol extract 1.0     4. Salvia whole plant 50% 1,3-butylene glycol extract 1.0     5. Whole citrus plant 50% 1,3-butylene glycol extract 1.0     6. Peony rhizome or root bark 60% ethanol extract 1.0     7. Sambucus nigra 50% 1,3-butylene glycol extract 1.0     8. Wood peel or fruit 50% 1,3-butylene glycol extract 1.0     9. Falcon sclerotium 50% 1,3-butylene glycol extract 1.0    10. Cantharis tincture 0.5    11. Pantothenic acid derivative 0.2    12.β-glycyrrhetinic acid 0.2    13. Resorcin 0.2    14. Salicylic acid 0.2    15. Hydroxyethyl chitosan solution 0.2    16. Elastin hydrolyzate 0.2    17. Antibacterial and antiseptic (paraben) 0.1    18. Perfume (lavender water) Suitable amount    19. Residue to make purified water 100

[0150] (Prescription example 27) Granule bath agent mass%     1. Sodium hydrogen carbonate 58.0     2. Anhydrous sodium sulfate 30.0     3. Borax 4.0     4. Silk protein enzymatic degradation solution dry powder 4.0     5. Salvia whole plant hot water extract dry powder 1.0     6. Rakanka whole grass hot water extract dry powder 1.0     7. Eucalyptus hot water extract dry powder 1.0     8. Jujube whole plant hot water extract dry powder 1.0     9. Dye (Gunzhou Green) Appropriate amount

[0151] (Prescription example 28) Granule bath agent mass%     1. Sodium hydrogen carbonate 38.0     2. Anhydrous sodium sulfate 30.0     3. Borax 2.0     4. Silk protein enzymatic degradation solution dry powder 2.0     5. Keratin protein enzyme decomposition solution dry powder 2.0     6. Collagen protein enzymatic decomposition solution dry powder 2.0     7. Salvia whole plant hot water extract dry powder 2.0     8. Yukinoshita whole grass hot water extract dry powder 2.0     9. Peach leaf 70% ethanol extract dry powder 1.0    10. Dye (Gunjou, chromium hydroxide)

(Prescription example 29) A protective solution for gauze or liniment cloth was impregnated with a prescription liquid prepared by mixing an appropriate amount of silk protein enzyme decomposition solution and salvia whole grass hot water extract, antibiotics, anti-inflammatory, etc., and attached to the wound area. To do. Alternatively, the silk protein enzymatic degradation solution and the salvia whole grass hot water extract may be directly sprayed locally and covered with gauze or the like.

[0153] (Prescription example 30) Mentsuyu mass%     1. Soy sauce 80.0     2. Black vinegar 2.0     3. Glucose 13.0     4. Sodium glutamate 2.0     5. Silk protein hydrolyzate powder of Production Example 1 1.5     6. Rakanka hot water extract dry powder 1.5

[0154] (Prescription example 31) Udon or buckwheat mass%     1. Wheat flour or buckwheat flour 90.0     2. Salt 1.0     3. Keratin protein degradation product powder 4.0 of Production Example 2     4. Bodaiju hot water extract dry powder 4.0     5. Dried powder of hot water extract of Renshen whole plant 1.0

[0155] (Prescription example 32) Beverage mass%     1. Glucose liquid sugar 30.0     2. Grapefruit juice 50.0     3. Collagen protein hydrolyzate powder of Production Example 9.0     4. Mucopolysaccharide solution 4.0     5. Iyokan juice 7.0     6. Perfume suitable amount     7. Suitable amount of acidulant

[0156] (Prescription example 33) Bread mass%     1.flour 80.0     2. Salt 1.0     3. Glucose 8.0     4.A: Silk protein hydrolyzate powder of Production Example 1       B: Keratin protein degradation product powder of Production Example 2       C: Collagen protein degradation product powder of Production Example 3       * Powder 3.0 of any one of A to C     5. Salvia whole grass hot water extract dry powder 2.0     6. Perilla leaf hot water extract dry powder 2.0     7. Carboxymethyl chitin solution 2.0     8. Vitamin E 1.0     9. Heme iron 1.0

[0157] (Formulation Example 34) sausage mass%     1. Ground meat 85.0     2. Chicken egg 5.0     3. Spice 1.0     4. Seasoning 1.0     5. Silk Protein Degradation Product Powder 4.0 of Production Example 1     6. Capsicum extract 4.0

[0158] (Formulation Example 35) gum mass%     1.Menthol Micron 30.0     2. Grapefruit flavor 60.0     3. Keratin protein enzyme decomposition solution dry powder 4.0     4. Crassulaceae whole plant extract dry powder 2.0     5. Artemisia leaf or stem hot water extract dry powder 2.0     6. Tannin 2.0

[0159] (Prescription example 36) Miso soup mass%     1. Tofu 30.0     2. Deep fried 5.0     3. carrot 5.0     4. Burdock 5.0     5. Chinese cabbage 5.0     6. Red miso 20.0     7. Silk protein alkali decomposition solution dry powder 5.0     8. The remaining amount of bonito dashi 100

[0160] (Prescription example 37) Cookie mass%     1.milk 62.0     2. Whole egg 14.5     3. Sugar 12.0     4. Constarch 5.0     5. Salt 0.5     6.A: Silk protein hydrolyzate powder of Production Example 1       B: Keratin protein degradation product powder of Production Example 2       C: Collagen protein degradation product powder of Production Example 3       * Powder 3.0 of any one of A to C     7.A: Triticum officinalis hot water extract dry powder of Production Example 4       B: Hypericum perforatum hot water extract dry powder of Production Example 4       C: Salvia hot water extract dry powder of Production Example 4       D: Dry powder of hot water extract of bodaiju of Production Example 4       E: Rakanka hot water extract dry powder of Production Example 4       * Any one of A to E extract 3.0     8. Fragrance suitable amount

(Test 8) Use effect test The effect of actually using the cosmetic composition of the present invention was examined. The usage test is for those who suffer from dry skin or rough skin, and for adult women with no skin tension and gloss, ages 30 to 50 each 3
0 people were panelists, and twice a day, morning and night, after washing the face, an appropriate amount of the emulsion of Formulation Example 1 was applied to the face for 3 months. As a control, emulsions obtained by removing the various proteolytic products of the present invention and various plant extracts from the emulsion were formulated by the same method. In addition, the evaluation method was carried out according to the following criteria, and the results are shown in Tables 8 to 9, and the numerical values in the table represent the number of people. No one complained of skin abnormality during the period of use. "Skin feel improvement effect" Effective: Dry skin and rough skin were improved, or skin tension and gloss were increased, and wrinkles and tarmi were improved. Slightly effective: Dry skin / roughness is slightly improved, or skin gloss /
The tension was slightly increased and wrinkles and tarmi were slightly improved. Ineffective: No change from before use.

[0162]

[Table 8]

[0163]

[Table 9]

(Test Results) As shown in Tables 8 to 9, the silk protein degradation product, keratin protein degradation product, collagen protein degradation product of the present invention, and further, the silk protein degradation product, keratin protein degradation product, collagen of the present invention 1 or more proteolytic products selected from proteolytic products, selected from Pleurotus cornucopiae, Hypericum perforatum, Salvia, Bodaiju, and Rakanka 1
The cosmetic composition containing at least one kind of plant extract showed an increase in skin tension and gloss, an improvement in wrinkles and tarmi, and an improvement in dry skin and rough skin, as compared with the control product.

(Test 9) Use effect test The effect of actually using the food of the present invention was examined. The usage test was conducted by 30 people aged 30 to 50 years old who suffer from dry skin and rough skin, and adult women who do not have gloss and tension of the skin. Each day, twice a day, morning and night, 5 cookies of Prescription Example 37 (approx. I had them eat 50g) for 3 months.
As a control, a cookie obtained by removing the various proteolytic products of the present invention and various plant extracts from the cookie and using the same method was used. In addition, the evaluation method was performed according to the following criteria, and the results are shown in Tables 10 to 11, and the numerical values in the table represent the number of people. No one complained of any abnormality during the period of use. "Skin feel improvement effect" Effective: Dry skin and rough skin were improved, or skin tension and gloss were increased, and wrinkles and tarmi were improved. Slightly effective: Dry skin / roughness is slightly improved, or skin gloss /
The tension was slightly increased and wrinkles and tarmi were slightly improved. Ineffective: No change from before use.

[0166]

[Table 10]

[0167]

[Table 11]

(Test Results) As shown in Tables 10 to 11, the silk protein degradation product, keratin protein degradation product, collagen protein degradation product of the present invention, and further, the silk protein degradation product, keratin protein degradation product, collagen of the present invention Compared to the control product, the food containing one or more kinds of proteolytic products selected from proteolytic products and one or more kinds of plant extracts selected from nematodes, Hypericum perforatum, Salvia, Bodaiju, and Rakanka has a firmer skin and gloss than the control product. Increase, improve wrinkles and tarmi,
Furthermore, dry skin and rough skin were improved.

[0169]

The one or more proteolytic products selected from the silk protein, keratin protein and collagen protein of the present invention have moisturizing action, skin aging preventing action and anti-inflammatory action,
Further, by further containing one or more kinds of plant extracts selected from Triturium japonicum, Hypericum, Salvia, Bodaiju, and Rakanka, it exerts a synergistic effect on the efficacy of the title, and is used internally or for humans or animals. It is safe for external use. Furthermore, it retains the moisture of the skin and improves dry skin,
It is effective for preventing skin aging by giving the skin gloss and tension and improving wrinkles and tarmi. It can also be used to prevent and improve inflammation caused by ultraviolet rays and inflammatory skin diseases (eg, rough skin, eczema, pruritus) associated therewith, and can be used in all forms of preparations (medicines, quasi drugs, cosmetics, foods). Can be applied to.

[Brief description of drawings]

FIG. 1 is a diagram showing the erythema level of the skin when the silk protein degradation product, the keratin protein degradation product, the collagen protein degradation product of the present invention and purified water as a control were administered.

[FIG. 2] Silk protein degradation product of the present invention + Crassulaceae extract, Silk protein degradation product + (Crassulaceae, Hypericum,
It is a figure which shows the erythema degree of the skin at the time of administering an equal amount mixture of each extract of Salvia, Bodaiju, and Rakanka) and purified water as a control.

FIG. 3 is a diagram showing that the keratin protein-decomposed product of the present invention + Phellinus linteus extract, the keratin protein-decomposed product + (equal mixture of extracts of Phyllanthus, Hypericum perforatum, Salvia, Bodige, and Rakanka) and purified water as a control are applied to the skin. It is a figure which shows the erythema degree of.

[Fig. 4] Collagen protein degradation product of the present invention + Crassulaceae extract, collagen protein degradation product + (Crassulaceae,
It is a figure which shows the erythema degree of the skin when administering the equal amount mixture of each extract of Hypericum perforatum, Salvia, Bodaijyu, and Rakanka) and purified water as a control.

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[Procedure amendment]

[Submission date] September 27, 2001 (2001.9.2)
7)

[Procedure Amendment 1]

[Document name to be corrected] Drawing

[Name of item to be corrected] Figure 3

[Correction method] Change

[Correction content]

[Figure 3]

[Procedure Amendment 2]

[Document name to be corrected] Drawing

[Name of item to be corrected] Fig. 4

[Correction method] Change

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[Figure 4]

Continued front page    F-term (reference) 4B018 LB01 LB02 LB06 LB08 LB09                       MD20 ME10 ME14                 4C083 AA072 AA082 AA111 AA112                       AA122 AB032 AB152 AB212                       AB232 AB242 AB312 AB352                       AB432 AB442 AC012 AC022                       AC102 AC122 AC132 AC182                       AC212 AC242 AC252 AC392                       AC422 AC432 AC442 AC472                       AC482 AC532 AC542 AC582                       AC642 AC682 AC692 AC712                       AC782 AC792 AC852 AD022                       AD092 AD112 AD272 AD312                       AD322 AD352 AD412 AD431                       AD432 AD441 AD442 AD451                       AD452 AD532 AD632 AD642                       AD662 CC04 CC05 CC06                       CC07 CC12 CC19 CC21 CC23                       CC25 CC32 CC33 CC37 CC38                       CC39 DD22 DD27 DD28 DD30                       DD33 EE12 EE17

Claims (8)

[Claims] 1. A moisturizer containing one or more proteolytic products selected from silk protein, keratin protein and collagen protein. 2. A skin anti-aging agent comprising one or more proteolytic products selected from silk protein, keratin protein and collagen protein. 3. An anti-inflammatory agent comprising one or more proteolytic products selected from silk protein, keratin protein and collagen protein. 4. A moisturizer containing the following (1) and (2) as essential components. (1) One or more proteolytic products selected from silk protein, keratin protein and collagen protein. (2) One or more kinds of plant extracts selected from triturium, Hypericum, Salvia, Bodaiju, and Rakanka. 5. A skin anti-aging agent comprising the following (1) and (2) as essential components. (1) One or more proteolytic products selected from silk protein, keratin protein and collagen protein. (2) One or more kinds of plant extracts selected from triturium, Hypericum, Salvia, Bodaiju, and Rakanka. 6. An anti-inflammatory agent containing the following (1) and (2) as essential components. (1) One or more proteolytic products selected from silk protein, keratin protein and collagen protein. (2) One or more kinds of plant extracts selected from triturium, Hypericum, Salvia, Bodaiju, and Rakanka. 7. A cosmetic composition comprising any one or more of the moisturizing agent, the skin anti-aging agent and the anti-inflammatory agent according to claim 1. 8. A food or drink containing at least one selected from the moisturizers, skin anti-aging agents and anti-inflammatory agents according to claim 1.