JP2015203012A - oral composition - Google Patents

Abstract

PROBLEM TO BE SOLVED: To provide a novel skin moisture retention oral composition, a skin wrinkle, sagging or firmness improving oral composition and a skin darkening improving oral composition.SOLUTION: Skin moisturizing effects, skin wrinkle, sagging or firmness improvement effects, and skin darkening improvement effects are obtained through oral ingestion of processed products of barley leaves.

Description

  The present invention relates to a skin moisturizing oral composition, a skin wrinkle, sagging or firmness improving oral composition, and a skin dullness improving oral composition characterized by comprising a processed product of barley leaves as an active ingredient. is there.

  Skin symptoms such as dry skin, wrinkles, sagging, reduced firmness and dullness are factors that impair the aesthetic appearance of the skin, and are therefore a source of trouble for women who care about beauty. Therefore, various skin moisturizers, wrinkle, sagging or firmness improving agents, and dullness improving agents have been developed so far for the purpose of improving these skin symptoms.

  For example, as a skin moisturizer, there is known a moisturizer (see Patent Document 1) containing, as an active ingredient, one or more plants selected from Lilyaceae plants, or an extract thereof. The skin wrinkle-improving agent is an external preparation for skin containing a polymer aqueous dispersion in which a water-insoluble film-forming polymer is dispersed in water, and the main component of the film-forming polymer is Further, a skin external preparation for improving wrinkles (see Patent Document 2) characterized by polyurethane having a film shrinkage rate of 20% or less and an acrylic polymer having a film shrinkage rate of 20% or less is known. Moreover, as a skin dullness improving agent, cosmetics containing ginsenoside 0.01-0.5 mass% and hesperidin and / or its glycoside 0.0001-0.05 mass% (refer patent document 3). )It has been known.

  However, many of these skin symptom improving agents are external preparations applied to the skin. As a composition for improving skin symptoms such as dry skin, wrinkles, sagging, firmness, dullness by ingestion, for example, containing kefir fermented milk, for whitening, for preventing and improving wrinkles and sagging, Although internal compositions for improving skin elasticity or moisturizing skin (see Patent Document 4) and the like are known, development is insufficient compared to external preparations. Therefore, there has been a demand for the development of a novel oral composition that improves skin symptoms such as dry skin, wrinkles, sagging, reduction in elasticity, and dullness.

JP 2009-096753 A JP-A-2005-200320 JP 2005-289913 A Japanese Patent No. 5048246

  In view of such circumstances, the present invention provides a skin moisturizing oral composition, skin wrinkle, sagging or firmness oral composition, and skin dullness, characterized by comprising a processed barley leaf product as an active ingredient. An object is to provide an improved oral composition.

  As a result of earnest research, the present inventors have shown that, by ingesting a processed barley leaf product, the skin moisturizing effect, skin wrinkle, sagging or firmness improving effect, skin dullness improving effect is exhibited. As a result, the present invention has been completed.

  That is, the present invention relates to a skin moisturizing oral composition characterized by comprising a processed product of barley leaves as an active ingredient. The present invention also relates to a skin wrinkle, sagging or firmness improving oral composition characterized by comprising a processed product of barley leaves as an active ingredient. The present invention also relates to an oral composition for improving skin dullness, characterized by comprising a processed product of barley leaves as an active ingredient.

  According to the present invention, a moisturizing effect can be exhibited by ingesting a moisturizing oral composition of the skin, characterized in that a processed barley leaf product is used as an active ingredient. That is, the present invention can be used as an oral moisturizer.

  In addition, according to the present invention, by taking an oral composition for improving wrinkles, sagging or firmness, characterized in that a processed product of barley leaves is used as an active ingredient, the elasticity of the skin is increased, Wrinkles, sagging or firmness can be improved. That is, the present invention can be used as a wrinkle, sagging or firmness improving agent for oral skin.

  Furthermore, according to the present invention, skin dullness can be improved by ingesting a dullness-improving oral composition characterized by containing a processed product of barley leaves as an active ingredient. That is, the present invention can be used as a dullness improving agent for oral skin.

Change in water content of stratum corneum by ingestion of processed barley leaves Change in water transpiration due to ingestion of processed barley leaves Changes in skin elasticity due to ingestion of processed barley leaves Questionnaire evaluation based on ingestion of processed barley leaves (dullness / brightness of skin)

  Hereinafter, embodiments of the present invention will be described. In addition, this invention is not limited by description of the below-mentioned embodiment, A various change is possible within the range of description in a claim.

  Barley (Hordeum vulgare L.) is native to Central Asia and is an annual or perennial herb belonging to the family Gramineae, and is roughly classified into Nijo barley and Rokujo barley, etc., depending on the ear shape. In addition, there are various varieties, and examples of Nijo barley include Nishinohoshi, Haruka Nijo, Nishino Chikara, Harushizuku, etc., and examples of Rojo Barley are doubled, Shunrai, Sanukihadaka, Daishimochi, Ichibamboshi, Fiber Snow, Silky Snow, Examples include Hanemugi, Kashimagoru, Akagami Riki (registered trademark), Minorimgi, Masaka Domugi, Suzukaze, Kashimamugi and the like.

  The skin moisturizing oral composition, skin wrinkle, sagging or firmness improving oral composition and skin dullness improving oral composition of the present invention use barley leaves as a raw material. The raw material only needs to contain barley leaves, and may contain other parts such as stems, ears and roots in addition to barley leaves, or the whole plant containing barley leaves may be used. good. The barley leaves used in the present invention are not particularly limited as long as they are usually available, and any barley leaves such as Nijo barley and Rojo barley may be used. In addition, barley leaves of any varieties may be used.

  The barley leaves used in the present invention are preferably harvested before the maturity period, that is, from the beginning of the splitting to the early stage of heading. Specifically, although different depending on the variety, it is generally preferable to harvest young leaves from barley having a height of about 30 to 60 cm. When the height of barley is less than 30 cm, the yield at the time of harvesting becomes worse because of the small leaf size. On the other hand, when the height of barley exceeds 60 cm, the barley emerges and the spikes are mixed into the harvest, so that the ratio of barley leaves in the harvest decreases. Barley leaves are preferably processed immediately after harvesting. When processing takes time, it is stored by storage means commonly used by those skilled in the art, such as cold storage, to prevent barley leaf alteration.

  In the present invention, the “processed barley leaf product” means a product processed by subjecting the barley leaf to a treatment such as drying, grinding, squeezing, extraction, etc. Not applicable to fresh leaves that have not been treated. Specifically, for example, barley leaf dry powder, barley leaf fragment and dried powder thereof, barley leaf juice and dried powder, barley leaf extract and dried powder thereof, etc. It is done. In addition, in this invention, a powder shall include what was granulated by adding an excipient | filler etc. as needed.

  As a method for dry powderization of barley leaves, any method known to those skilled in the art may be used for dry powderization, and conventionally known methods may be used. For example, after cutting barley leaves, a blanching treatment is performed, followed by drying so that the water content is 10% by mass or less, preferably 5% by mass or less, and then pulverizing (Japanese Patent Laid-Open No. 2004-000210). Gazette), after cutting barley leaves, blanching treatment, then twisting, then drying and crushing (see JP 2002-0665204), drying barley leaves, Examples of the method include a method of heating at 110 ° C. or higher after pulverization, and further pulverizing (see Japanese Patent Laid-Open No. 2003-033151).

  As a method for fragmenting the barley leaf, it may be fragmented by a method commonly used by those skilled in the art, and a conventionally known method may be used. For example, the method of fragmenting a plant body by slicing, shredding, etc. is mentioned. As an example of fragmentation, a slurry may be used. Slurry may be performed by a method in which barley leaves are put into a mixer, a juicer, a blender, a mass collider, or the like, and the barley leaves are crumpled (liquid and solid suspension).

  As a method of drying the barley leaf fragment, a method commonly used by those skilled in the art may be used, and a conventionally known method may be used. Examples thereof include a method of drying in the sun, and a method of drying by spray drying, freeze drying, reduced pressure drying, fluidized drying and the like using a dryer.

  As a method of squeezing barley leaves, the squeeze may be performed by a method commonly used by those skilled in the art, and a conventionally known method may be used. For example, the method of squeezing a barley leaf or a fragmented product thereof, the method of centrifuging or filtering the fragmented product of a barley leaf, etc. Note that the juice may be concentrated as necessary. Moreover, you may use the squeeze residue which remains after squeezing a barley leaf as a processed product of a barley leaf.

  As a method for dry pulverizing the barley leaf juice, the juice may be dry powdered by a method commonly used by those skilled in the art, and a conventionally known method may be used. For example, the juice may be dried and powdered as it is, or an appropriate binder or excipient may be added to the juice and dried to be powdered. Moreover, an excipient | filler etc. may be added as needed to the squeezed product or the dried powder of the squeezed product, and it may shape | mold and granulate by the granulation method of well-known wet and dry methods.

  As a method for extracting barley leaves, a method commonly used by those skilled in the art may be used, and a conventionally known method may be used. For example, a method of adding an extraction solvent usually used by those skilled in the art, such as ethanol, water, hydrous ethanol, etc. to barley leaves or a fragmented product thereof, and heating and extracting as necessary. In addition, you may concentrate an extract as needed. In order to increase the concentration of the specific component, the extract may be fractionated by a method commonly used by those skilled in the art, or the specific component may be purified by a method commonly used by those skilled in the art. Moreover, you may use the extraction residue which remains after performing an extraction process from a barley leaf as a processed product of a barley leaf.

  As a method for dry-pulverizing the barley leaf extract, the extract may be dry-powdered by a method commonly used by those skilled in the art, and a conventionally known method may be used. For example, the extract may be dried and pulverized, or an appropriate binder or excipient may be added to the extract and then dried to be pulverized. Moreover, an excipient | filler etc. may be added to an extract or the dry powder of an extract as needed, and it may shape | mold and pulverize to a granule by well-known wet granulation methods, such as a dry type.

  As described above, any processed barley leaf product according to the present invention can be used as long as it is a processed product of barley leaves. Among them, dry powder of barley leaves has a high effect. In view of this, it is particularly preferable to use a dry powder of barley leaves.

  The processed barley leaf product of the present invention may be sterilized by ordinary methods such as air sterilization, high-pressure sterilization, and heat sterilization.

  In the skin moisturizing oral composition, skin wrinkle, sagging or firmness improving oral composition, skin dullness improving oral composition of the present invention, the content of processed barley leaves hinders the solution of the problems of the present invention. Unless otherwise specified, for example, it is 0.1% by mass or more, preferably 0.5% by mass or more, more preferably 1% by mass or more, still more preferably 10% by mass or more, and most preferably It is 20 mass% or more. When the content of the barley leaf processed product is less than 0.1% by mass, the effects of the present invention may not be sufficiently exhibited.

  In the skin moisturizing oral composition, skin wrinkle, sagging or firmness improving oral composition, skin dullness improving oral composition of the present invention, the daily intake of processed barley leaves is not particularly limited, When the intake amount is too small, the effect of the present invention may not be sufficiently exhibited. In this respect, the daily intake is preferably 0.1 g or more, more preferably 0.3 g or more, still more preferably 0.5 g or more, and most preferably 1 g or more. On the other hand, when there is too much intake per day, it will be overdose, and there exists a possibility that the effect of this invention may not fully be exhibited conversely. In this respect, the daily intake is preferably 8 g or less, more preferably 7.5 g or less, still more preferably 7.2 g or less, and most preferably 7 g or less. As described above, the skin moisturizing oral composition, skin wrinkle, sagging or firmness improving oral composition, and skin dullness improving oral composition of the present invention are particularly excellent when the daily intake is in a specific range. Can exert the effect.

  The skin moisturizing oral composition, skin wrinkle, sagging or firmness improving oral composition, skin dullness improving oral composition of the present invention may contain an active ingredient in addition to the processed barley leaf product, The effect of the present invention can be exhibited even if only the processed barley leaf product is used as an active ingredient without containing any ingredients. Therefore, the oral composition of this invention does not need to contain the raw material which has a beauty effect other than the processed product of a barley leaf. Examples of materials having a cosmetic effect include mucopolysaccharides, ceramides, collagen, and nucleic acids. Mucopolysaccharides include hyaluronic acid and chondroitin sulfate. Examples of ceramides include ceramide, glucosylceramide, and galactosylceramide. Examples of nucleic acids include deoxyribonucleic acid (DNA) and ribonucleic acid (RNA). In addition, in this application, the oral composition of the present invention “contains” an ingredient (eg, DNA, etc.) that is usually contained in plant or animal-derived raw materials means that the raw material obtained by concentrating and purifying the ingredients is the oral composition of the present invention. It means that it was intentionally added to the product. Therefore, for example, when a purified product of DNA extracted from a certain plant is added as a raw material to the oral composition of the present invention, the oral composition of the present invention "contains" DNA in the definition of the present application. On the other hand, for example, when a plant extract is added to the oral composition of the present invention as a raw material, and the plant extract contains a small amount of DNA, the plant extract is obtained by concentrating and purifying the DNA. Unless otherwise defined, the oral composition of the invention does not “comprise” DNA.

  The skin moisturizing oral composition, skin wrinkle, sagging or firmness improving oral composition and skin dullness improving oral composition of the present invention can be in any form using the processed product. As the form of the oral composition of the present invention, a form suitable for oral intake, for example, powder, granule, granule, tablet, rod, plate, block, solid, round, liquid, bowl, Examples include pastes, creams, capsules such as hard capsules and soft capsules, caplets, tablets, gels, jellies, gummi, wafers, chewables, syrups, sticks, and the like. When the oral composition of the present invention is in a solid form, it can be mixed with water, suspended or dissolved, and orally ingested as a liquid form. It may be taken orally as it is. Moreover, you may add not only to water but to liquids, such as tea and milk.

  The skin moisturizing oral composition, skin wrinkle, sagging or firmness improving oral composition, and skin dullness improving oral composition of the present invention are not particularly limited in blending with other ingredients, and if necessary, barley Ingredients other than leaves may be blended. Examples of components other than barley leaves include vitamins (A, C, D, E, K, folic acid, pantothenic acid, biotin, derivatives thereof, etc.), minerals (iron, magnesium, calcium, zinc, selenium, etc.). , Α-lipoic acid, lecithin, polyphenols (flavonoids, derivatives thereof, etc.), carotenoids (lycopene, astaxanthin, zeaxanthin, lutein, etc.), xanthine derivatives (caffeine, etc.), fatty acids, amino sugars (glucosamine, acetylglucosamine, galactosamine) , Acetylgalactosamine, neuraminic acid, acetylneuraminic acid, hexosamine, their salts, etc.), oligosaccharides (isomalto-oligosaccharides, cyclic oligosaccharides, etc.), plant dry powder, animal and plant extracts, sulfur-containing compounds (alliin, sepaene, taurine) , Glutathione, methylsulfonylme Emissions, etc.), sugar alcohols, sugars, lignans (sesamin, etc.) and the like may be blended. In addition, acidulants such as citric acid, lactic acid, gluconic acid and apple, colorants such as titanium oxide, thickeners such as gum arabic and xanthan gum, sweeteners such as thaumatin and reduced maltose, brighteners such as shellac, talc, Manufacturing agents such as silicon dioxide, cellulose, calcium stearate, etc. may be blended, and various excipients, binders, lubricants, stabilizers, diluents, extenders, thickeners, emulsifiers, coloring A fragrance, a fragrance, an additive and the like may be blended. In addition, content of components other than a barley leaf can be suitably selected according to the form etc. of the oral composition of this invention.

  Hereinafter, the present invention will be described in more detail with reference to examples. Needless to say, the scope of the present invention is not limited to the following examples.

(Example: Examination of effects of oral intake of processed barley leaves)
In order to confirm whether or not moisturizing effect, skin wrinkle, sagging or firmness improvement effect, or skin dullness improvement effect was observed by ingesting processed barley leaves, double blind An inter-group test was conducted.

(1) Test subjects Eighteen women aged 35 to under 55 who have rough skin symptoms (dryness, breakout) were examined.

(2) Manufacture of test product or placebo product Test product or placebo product powder was manufactured according to the formulation shown in Table 1. Because the placebo product contains a colorant, the placebo product and the test product cannot be visually distinguished. In addition, it is thought that the starch, coloring agent, and fragrance | flavor contained in a placebo product do not affect the effect of this invention.

(3) Test method Eighteen test subjects were divided into two groups so that the skin moisture (cheek), skin moisture transpiration (cheek) and age in the pre-intake test were as equal as possible. Grouped. The test group was ingested with the test product and the comparative group with the placebo product once a day, 1 g, continuously for 8 weeks. In addition, the test product or the placebo product was orally ingested by dissolving in 100 mL of water or hot water.

(4) Evaluation method About the item described below, evaluation by the measurement test or the questionnaire was implemented. Measurement tests and questionnaires were conducted before ingestion, 4 weeks after ingestion and 8 weeks after ingestion. In addition, the measurement test was performed after acclimatization for 20 minutes in an environment adjustment room (temperature 21 ° C. ± 1 ° C., humidity 50% ± 10%) in which temperature and humidity were controlled.

1) Corneal layer moisture content The left cheekbone apex was measured using a Corneometer (Corneometer CM825, manufactured by Curage-Khazaka) as a measuring instrument.

2) Amount of moisture transpiration A tevameter (Tewometer TM300, manufactured by Curage-Khazaka) was used as a measuring instrument, and the apex of the left cheekbone was measured.

3) Elasticity A cut meter (Cumeter MPA580, manufactured by Curage-Khazaka) was used as a measuring instrument, and the inner side of the left forearm was measured.

4) Dullness / Skin Brightness A questionnaire was used to evaluate the item “Dullness / Skin Brightness”. The evaluation criteria are as follows.
(Evaluation criteria)
1 point: Very anxious (dark)
2 points: Slightly anxious (dark)
3 points: Neither 4 points: Slightly distracted (bright)
5 points: Not very concerned (bright)

(5) Results 1) Amount of stratum corneum moisture and moisture transpiration FIG. 1 shows the amount of change in stratum corneum moisture, and FIG. 2 shows the amount of change in moisture transpiration. The numerical values in FIGS. 1 and 2 mean the amount of change (average value) based on the numerical values before ingestion. As shown in FIGS. 1 and 2, in the test group that orally ingested the barley leaf processed product, the stratum corneum moisture content of the skin was higher than that of the comparative group, but the moisture transpiration amount was lower. In the test group, an increase in the stratum corneum water content was observed at 4 weeks and 8 weeks after ingestion compared to before intake. From this, it was suggested that the effect of improving the moisture retention of the skin can be obtained by ingesting the processed barley leaf product.

2) Skin elasticity Fig. 3 shows the amount of change in skin elasticity. The numerical value of FIG. 3 means the change amount (average value) of the numerical value based on the numerical value before ingestion. As shown in FIG. 3, the elasticity of the skin was higher in the test group that orally ingested the processed barley leaves than in the comparative group. In the test group, an increase in skin elasticity was observed at 4 weeks and 8 weeks after ingestion compared to before intake. An increase in skin elasticity is thought to lead to an improvement in skin wrinkles, sagging or firmness. From this, it was suggested that the wrinkle, sagging or firmness improving effect of the skin can be obtained by ingesting the processed barley leaf product.

2) Questionnaire evaluation (dullness / brightness of skin)
FIG. 4 shows the results of a questionnaire evaluation of dullness / skin brightness. The numerical value of FIG. 4 means the score (average value) of five steps of evaluation. As shown in FIG. 4, the evaluation group for dullness and skin brightness was higher in the test group that orally ingested the processed barley leaf product, compared with the comparative group. Further, in the test group, an increase in evaluation points for dullness and skin brightness was observed after 4 weeks and 8 weeks after ingestion compared to before intake. From this, it was suggested that the dullness improvement effect of the skin can be obtained by ingesting the processed barley leaves.

(Production example of the present invention)
The skin moisturizing oral composition, skin wrinkle, sagging or firmness improving oral composition, skin dullness improving oral composition of the present invention can be used in various forms. For example, it can use as a form of manufacture examples 1-6 described below. Needless to say, embodiments of the present invention are not limited to the following.

(Production Example 1: Solution)
Each component was mix | blended in the ratio described in Table 2, and the liquid agent was manufactured. Ingesting 5 to 400 mL of this solution per day (intake of processed barley leaves is 0.1 to 8 g per day), improving skin moisturizing effect, improving skin wrinkle, sagging or firmness Or, it can be expected that an effect of improving skin dullness is obtained.

(Production Example 2: Granules)
Each component was mixed so that it may become the ratio described in Table 3, and it granulated by the fluidized-bed granulation. The obtained granulated product was sieved with a 30-mesh sieve to obtain granules. By taking 2-30 g of this granule per day (the intake of processed barley leaves is 0.5-7.5 g per day), the moisturizing improvement effect on the skin, wrinkles on the skin, sagging or It can be expected that a firmness improving effect or a dull skin improving effect can be obtained.

(Production Example 3: Solution)
Production Example 3 was prepared in the same manner as in Production Example 1 except that the dried powder of barley leaf juice was used instead of the dried powder of barley leaf. Ingesting 5 to 400 mL of this solution per day (intake of processed barley leaves is 0.1 to 8 g per day), improving skin moisturizing effect, improving skin wrinkle, sagging or firmness Or, it can be expected that an effect of improving skin dullness is obtained.

(Production Example 4: Granules)
Production Example 4 was produced in the same manner as in Production Example 2 except that the dried powder of barley leaf juice was used instead of the dried powder of barley leaves. By taking 2-30 g of this granule per day (the intake of processed barley leaves is 0.5-7.5 g per day), the moisturizing improvement effect on the skin, wrinkles on the skin, sagging or It can be expected that a firmness improving effect or a dull skin improving effect can be obtained.

(Production Example 5: Solution)
Production Example 5 was prepared in the same manner as in Production Example 1 except that the dried powder of barley leaf water extract was used instead of the dried powder of barley leaves. Ingesting 5 to 400 mL of this solution per day (intake of processed barley leaves is 0.1 to 8 g per day), improving skin moisturizing effect, improving skin wrinkle, sagging or firmness Or, it can be expected that an effect of improving skin dullness is obtained.

(Production Example 6: Granule)
Production Example 6 was prepared in the same manner as in Production Example 2 except that a dry powder of an aqueous extract of barley leaves was used instead of the dried powder of barley leaves. By taking 2-30 g of this granule per day (the intake of processed barley leaves is 0.5-7.5 g per day), the moisturizing improvement effect on the skin, wrinkles on the skin, sagging or It can be expected that a firmness improving effect or a dull skin improving effect can be obtained.

Claims (3)

  A skin moisturizing oral composition comprising a processed barley leaf as an active ingredient.   An oral composition for improving skin wrinkles, sagging or firmness, characterized by comprising a processed product of barley leaves as an active ingredient.   An oral composition for improving skin dullness, comprising a processed product of barley leaves as an active ingredient.