JP6646692B2 - Oral composition - Google Patents

Description

  The present invention relates to an oral composition for moisturizing the skin, an oral composition for improving skin wrinkles, sagging or firmness, and an oral composition for improving skin dullness, characterized in that a processed barley leaf is used as an active ingredient. is there.

  Skin symptoms such as dry skin, wrinkles, sagging, reduced firmness, and dullness are factors that impair the aesthetic appearance of the skin, and are a cause of concern for women who care about beauty. Therefore, various skin moisturizers, wrinkle, sagging or firming improvers, and dullness improvers have been developed for the purpose of improving these skin symptoms.

  For example, as a skin moisturizer, a moisturizer containing one or more plants selected from a plant of the genus Liliaceae (Cardiocrineum) or an extract thereof as an active ingredient (see Patent Document 1) is known. The skin wrinkle improver is a skin external preparation containing a polymer water dispersion in which a water-insoluble film-forming polymer is dispersed in water, wherein the main component of the film-forming polymer is A skin external preparation for improving wrinkles, which is a polyurethane having a film formation shrinkage of 20% or less and an acrylic polymer having a film formation shrinkage of 20% or less (see Patent Document 2). In addition, as a dulling agent for skin, a cosmetic containing 0.01 to 0.5% by mass of ginsenoside and 0.0001 to 0.05% by mass of hesperidin and / or its glycoside (see Patent Document 3). )It has been known.

  However, many of these skin symptom ameliorating agents are external preparations applied to the skin for use. By oral ingestion, dry skin, wrinkles, sagging, reduction of firmness, as a composition for improving skin symptoms such as dullness, for example, containing kefir fermented milk, for whitening, for prevention and improvement of wrinkles and sagging, Although an internal composition for improving skin elasticity or moisturizing the skin (see Patent Document 4) and the like are known, their development is insufficient compared with external preparations. Therefore, development of a novel oral composition that improves skin symptoms such as dry skin, wrinkles, sagging, reduction of firmness, and dullness has been demanded.

JP 2009-097553 A JP 2005-200320 A JP 2005-289913 A Japanese Patent No. 5048246

  In view of such circumstances, the present invention provides an oral composition for moisturizing the skin, an oral composition for improving wrinkles, sagging or firmness of the skin, and a dull skin. It is intended to provide an improved oral composition.

  The present inventors have conducted intensive studies and found that, by orally ingesting a processed product of barley leaf, the moisturizing effect on the skin, the effect of improving skin wrinkles, sagging or firmness, and the effect of improving skin dullness are exhibited. And completed the present invention.

  That is, the present invention relates to an oral moisturizing composition for skin, comprising a processed barley leaf as an active ingredient. The present invention also relates to an oral composition for improving skin wrinkles, sagging or firmness, comprising a processed barley leaf as an active ingredient. The present invention also relates to an oral composition for improving skin dullness, comprising a processed barley leaf as an active ingredient.

  ADVANTAGE OF THE INVENTION According to this invention, the moisturizing effect can be exhibited by ingesting the moisturizing oral composition of the skin, which comprises a processed barley leaf as an active ingredient. That is, the present invention can be used as an oral humectant.

Further, according to the present invention, a processed barley leaf is used as an active ingredient, and by ingesting an oral composition for improving wrinkles, sagging or firmness of skin, the elasticity of the skin is increased, and Wrinkles, sagging or firmness can be improved. That is, the present invention can be used as an agent for improving wrinkles, sagging or firmness of oral skin.

  Further, according to the present invention, it is possible to improve the dullness of the skin by ingesting the oral composition for improving dullness of the skin, which comprises a processed product of barley leaves as an active ingredient. That is, the present invention can be used as an oral skin dulling agent.

Changes in water content of the stratum corneum due to ingestion of processed barley leaves Change in water loss due to ingestion of processed barley leaf Changes in skin elasticity due to ingestion of processed barley leaves Questionnaire evaluation by ingestion of processed barley leaves (dullness / skin brightness)

  Hereinafter, embodiments of the present invention will be described. It should be noted that the present invention is not limited by the description of the embodiments described below, and various changes can be made within the scope of the claims.

  Barley (Hordeum vulgare L.) is native to Central Asia, is an annual or annual herb belonging to the Poaceae family, and is roughly classified into two-row barley and six-row barley, etc., depending on the ear shape. In addition, there are various varieties, and examples of Nijo barley include Nishinohoshi, Haruka Nijo, Nishinochichikara, Harushizuku, etc.Examples of Rojo barley are Harvest, Shunrai, Sanuki naked mosquito, Daishimochi, Ichibanboshi, Fiber snow, Silky snow, Examples include Hanemugi, Kashimagor, Akagami Riki (registered trademark), Minorimugi, Masakadomugi, Soukaze, Kashimamugi, and the like.

The oral moisturizing composition for skin, the oral composition for improving skin wrinkles, sagging or firmness, and the oral composition for improving skin dullness use barley leaves as raw materials. It is sufficient that the raw material contains barley leaves, and in addition to the barley leaves, other parts such as stems, ears, roots, etc. may be included, or whole plants including barley leaves may be used. good. The barley leaves used in the present invention are not particularly limited as long as they are generally available, and any barley leaves such as two-row barley and six-row barley may be used. Barley leaves of any variety may be used.

  The barley leaves used in the present invention are preferably harvested before the maturation period, that is, from the beginning of tillering to the beginning of heading. Specifically, it is generally preferable to harvest young leaves from barley having a height of about 30 to 60 cm, although it varies depending on the variety. If the height of the barley is less than 30 cm, the yield at harvesting will be poor due to the small size of the leaves. On the other hand, when the height of the barley exceeds 60 cm, the ratio of the barley leaf in the harvest decreases because the barley emerges and ears are mixed into the harvest. Barley leaves are preferably processed immediately after harvesting. When time is required for the treatment, the barley is stored by a storage means commonly used by those skilled in the art, such as low-temperature storage, in order to prevent deterioration of the leaves of the barley.

  In the present invention, the term "processed barley leaf" means a processed barley leaf processed by subjecting it to a drying treatment, a crushing treatment, a squeezing treatment, an extraction treatment, etc. Fresh leaves that have not been treated are not applicable. Specifically, for example, barley leaf dry powder, barley leaf fragment and its dry powder, barley leaf squeezed and its dry powder, barley leaf extract and its dry powder, etc. Can be In the present invention, the term "powder" includes a powder obtained by adding an excipient or the like as necessary and granulating.

  As a method of dry-pulverizing the leaves of barley, a method commonly used by those skilled in the art may be dry-pulverized, and a conventionally known method may be used. For example, after barley leaves are cut, blanching treatment is performed, and then drying is performed so that the water content becomes 10% by mass or less, preferably 5% by mass or less, and then pulverization (Japanese Patent Application Laid-Open No. 2004-000210). Japanese Patent Application Laid-Open No. 2002-065204), a method of cutting barley leaves, performing a blanching treatment, then kneading, then drying and pulverizing (see JP-A-2002-0665204), drying barley leaves, After pulverization, a method of heating at 110 ° C. or more and further pulverizing (see JP-A-2003-033151) can be mentioned.

  Barley leaves may be cut into pieces by a method commonly used by those skilled in the art, and a conventionally known method may be used. For example, there is a method of slicing a plant body by slicing, shredding, or the like. As an example of the fragmentation, a slurry may be formed. The slurrying may be performed by a method in which the barley leaves are mixed with a mixer, a juicer, a blender, a mascoloider, or the like, and the barley leaves are made into a thick porridge (a suspension of a liquid and a solid).

  As a method for drying the barley leaf shreds, a person skilled in the art may use a method commonly used, or a conventionally known method. For example, a method of drying in the sun, a method of spray-drying, freeze-drying, drying under reduced pressure, fluidized-drying using a dryer, and the like can be mentioned.

  The barley leaves may be squeezed by a method commonly used by those skilled in the art, and a conventionally known method may be used. For example, a method of squeezing a barley leaf or a fragment thereof, a method of centrifuging or filtering the fragment of a barley leaf, and the like can be given. The juice may be concentrated if necessary. In addition, the juice residue remaining after the juice processing from the barley leaves may be used as a processed product of the barley leaves.

  As a method of dry-pulverizing the squeezed product of barley leaves, the squeezed product may be dried and powdered by a method usually used by those skilled in the art, and a conventionally known method may be used. For example, the juice may be dried and powdered as it is, or an appropriate binder, an excipient and the like may be added to the juice and dried to be powdered. Alternatively, an excipient or the like may be added to the squeezed product or the dried powder of the squeezed product, if necessary, and the mixture may be formed into granules by a known wet or dry granulation method, and powdered.

  As a method for extracting barley leaves, a method commonly used by those skilled in the art may be used, and a conventionally known method may be used. For example, a method may be used in which an extraction solvent commonly used by those skilled in the art such as ethanol, water, and aqueous ethanol is added to barley leaves or a fragment thereof, and the mixture is heated and extracted as necessary. The extract may be concentrated if necessary. Further, in order to increase the concentration of the specific component, the extract may be fractionated by a method commonly used by those skilled in the art, or the specific component may be purified by a method commonly used by those skilled in the art. Further, the extraction residue remaining after performing the extraction treatment from the barley leaves may be used as a processed product of the barley leaves.

  As a method of dry-pulverizing the extract of barley leaves, the extract may be dry-pulverized by a method usually used by those skilled in the art, and a conventionally known method may be used. For example, the extract may be dried and powdered, or the extract may be dried after adding an appropriate binder, excipient, or the like. In addition, an excipient or the like may be added to the extract or the dry powder of the extract as necessary, and the powder may be formed into granules by a known granulation method such as a wet or dry granulation method and powdered.

  As described above, as a processed product of barley leaves of the present invention, any barley leaves that have been subjected to some processing can be used, and among them, dry powder of barley leaves has a high effect. For this reason, it is particularly preferable to use dry powder of barley leaves.

  The processed barley leaf product of the present invention may be sterilized by a method such as ordinary airflow sterilization, high-pressure sterilization, and heat sterilization.

In the oral moisturizing composition for skin, the oral composition for improving skin wrinkles, sagging or firmness, and the oral composition for improving skin dullness, the content of the processed product of barley leaves prevents the solution of the problem of the present invention. It is not particularly limited as long as it is not present, but is, for example, 0.1% by mass or more, preferably 0.5% by mass or more, more preferably 1% by mass or more, still more preferably 10% by mass or more, and most preferably 20% by mass or more. When the content of the processed barley leaf is less than 0.1% by mass, the effects of the present invention may not be sufficiently exerted.

In the oral moisturizing composition for skin, the oral composition for improving skin wrinkles, sagging or firmness, and the oral composition for improving skin dullness, the daily intake of the processed barley leaf product is not particularly limited, If the intake is too small, the effects of the present invention may not be sufficiently exhibited. In this respect, the daily intake is preferably 0.1 g or more, more preferably 0.3 g or more, still more preferably 0.5 g or more, and most preferably 1 g or more. On the other hand, if the daily intake is too large, excessive intake will result, and conversely, the effects of the present invention may not be sufficiently exhibited. In this respect, the daily intake is preferably 8 g or less, more preferably 7.5 g or less, still more preferably 7.2 g or less, and most preferably 7 g or less. As described above, the oral moisturizing composition for skin, the oral composition for improving skin wrinkles, sagging or firmness, and the oral composition for improving skin dullness are particularly excellent when the daily intake is in a specific range. The effect can be exhibited.

The oral moisturizing composition for skin, the oral composition for improving skin wrinkles, sagging or firmness, and the oral composition for improving skin dullness may contain an active ingredient in addition to the processed barley leaf product. The effect of the present invention can be exerted even if only a processed barley leaf is used as an active ingredient without containing any component. Therefore, the oral composition of the present invention may not include a material having a cosmetic effect other than the processed barley leaf. Materials having a cosmetic effect include mucopolysaccharides, ceramides, collagen and nucleic acids. Mucopolysaccharides include hyaluronic acid and chondroitin sulfate. Ceramides include ceramide, glucosylceramide and galactosylceramide. Nucleic acids include deoxyribonucleic acid (DNA) and ribonucleic acid (RNA). In the present application, the term “contains” a component (eg, DNA, etc.) that is usually contained in plant- or animal-derived materials means that the ingredient obtained by concentrating and purifying the component is an oral composition of the present invention. Means intentionally added to the product. Therefore, for example, when a purified product of DNA extracted from a certain plant is added as a raw material to the oral composition of the present invention, the oral composition of the present invention "contains" DNA according to the definition of the present application. On the other hand, for example, an extract obtained by adding a certain plant extract to the oral composition of the present invention as a raw material and enriching and purifying the DNA even if the plant extract contains a trace amount of DNA. Unless otherwise defined, oral compositions of the present invention do not "comprise" DNA by definition herein.

  The oral moisturizing composition for skin, the oral composition for improving skin wrinkles, sagging or firmness, and the oral composition for improving skin dullness can be in any form using the processed product. As the form of the oral composition of the present invention, a form suitable for oral ingestion, for example, powder, granule, granule, tablet, rod, plate, block, solid, round, liquid, candy, Examples include pastes, creams, capsules such as hard capsules and soft capsules, caplets, tablets, gels, jellies, gummy, wafers, chewables, syrups, and sticks. When the oral composition of the present invention is in the form of a solid, it can be mixed with water and suspended or dissolved to be ingested orally as a liquid. It may be taken orally as is. Further, it may be added not only to water but also to liquids such as tea and milk.

  The oral moisturizing composition for skin, the oral composition for improving skin wrinkles, sagging or firmness, and the oral composition for improving skin dullness are not particularly limited to blending other components, and if necessary, barley. You may mix components other than a leaf. Components other than barley leaves include, for example, vitamins (A, C, D, E, K, folic acid, pantothenic acid, biotin, derivatives thereof, etc.) and minerals (iron, magnesium, calcium, zinc, selenium, etc.) , Α-lipoic acid, lecithin, polyphenols (flavonoids, derivatives thereof, etc.), carotenoids (lycopene, astaxanthin, zeaxanthin, lutein, etc.), xanthine derivatives (caffeine, etc.), fatty acids, amino sugars (glucosamine, acetylglucosamine, galactosamine) , Acetylgalactosamine, neuraminic acid, acetylneuraminic acid, hexosamine, salts thereof, etc., oligosaccharides (isomaltooligosaccharides, cyclic oligosaccharides, etc.), plant dry powder, plant and animal extracts, sulfur-containing compounds (allyin, sepaen, taurine) , Glutathione, methylsulfonylme Emissions, etc.), sugar alcohols, sugars, lignans (sesamin, etc.) and the like may be blended. Also, citric acid, lactic acid, gluconic acid, acidulants such as apples, coloring agents such as titanium oxide, gum arabic, thickeners such as xanthan gum, thaumatin, sweeteners such as reduced maltose, brighteners such as shellac, talc, Production agents such as silicon dioxide, cellulose, calcium stearate, etc. may be blended, and various excipients, binders, lubricants, stabilizers, diluents, extenders, thickeners, emulsifiers, coloring Ingredients, fragrances, additives and the like may be blended. The content of components other than barley leaves can be appropriately selected according to the form of the oral composition of the present invention.

  Hereinafter, the present invention will be described in more detail with reference to examples. It goes without saying that the scope of the present invention is not limited to the following examples.

(Example: Examination of the effect of oral intake of processed barley leaves)
The following methods are used to confirm whether orally ingesting the processed barley leaves to improve the moisturizing effect, the effect of improving skin wrinkles, sagging or firmness, or the effect of improving skin dullness. A parallel group test was performed.

(1) Test subjects Eighteen women aged 35 to 55 with rough skin symptoms (dryness, pimples) were tested.

(2) Production of test article or placebo article Powder of the test article or placebo article was produced according to the formulation shown in Table 1. Because placebo products contain colorants, it is not possible to visually distinguish the placebo product from the test product. It should be noted that the starch, colorant, and flavor contained in the placebo product are not considered to affect the effects of the present invention.

(3) Test method Eighteen women to be tested were divided into two groups so that the skin water content (cheek), skin water transpiration (cheek) and age in the pre-ingestion test were as equal as possible. Groups. The test group was ingested with the test article for the test group, and the placebo article was ingested once a day for 1 week at a time for 8 weeks. The test product or the placebo product was orally ingested by dissolving in 100 mL of water or hot water and drinking.

(4) Evaluation method The following items were evaluated by measurement tests or questionnaires. The measurement test and questionnaire were performed before intake, 4 weeks after intake, and 8 weeks after intake. Note that the measurement test was performed after acclimation for 20 minutes in an environment control room (temperature 21 ° C. ± 1 ° C., humidity 50% ± 10%) in which temperature and humidity were controlled.

1) Using a corneometer (Corneometer CM825, manufactured by Courage-Khazaka) as a stratum corneum moisture content measuring device, measurement was performed on the apex of the left cheekbone.

2) Using a tevameter (Tewameter TM300, manufactured by Courage-Khazaka) as a device for measuring the amount of water evaporation, the apex of the left cheekbone was measured.

3) Using a cute meter (Cutometer MPA580, manufactured by Courage-Khazaka) as an elasticity measuring device, the measurement was performed on the left forearm inner part.

4) Dullness / Brightness of Skin The item of "dullness / brightness of skin" was evaluated by a questionnaire. The evaluation criteria are as follows.
(Evaluation criteria)
1 point: very anxious (dark)
2 points: slightly anxious (dark)
3 points: neither of them 4 points: slightly annoying (bright)
5 points: Very uninteresting (bright)

(5) Results 1) Stratum corneum water content and water loss Figure 1 shows the change in the water content of the stratum corneum, and Figure 2 shows the change rate of the water loss. 1 and 2 mean the amount of change (average value) of the numerical value based on the numerical value before ingestion. As shown in FIG. 1 and FIG. 2, in the test group in which the processed barley leaf was ingested orally, the water content of the stratum corneum of the skin was higher than that in the comparative group, while the water evaporation was lower. In the test group, an increase in the horny layer water amount was observed 4 weeks and 8 weeks after ingestion as compared to before the ingestion. This suggested that ingestion of the processed barley leaf product orally could improve skin moisturizing.

2) Elasticity of the skin FIG. 3 shows the amount of change in the elasticity of the skin. The numerical value in FIG. 3 means the amount of change (average value) of the numerical value based on the numerical value before ingestion. As shown in FIG. 3, the test group in which the processed barley leaf was orally ingested had higher skin elasticity than the comparative group. In the test group, an increase in skin elasticity was observed 4 weeks and 8 weeks after ingestion as compared to before the ingestion. An increase in skin elasticity is believed to lead to an effect of improving skin wrinkles, sagging or firmness. This suggests that orally ingesting the processed barley leaf leaves can improve skin wrinkles, sagging or firmness.

2) Questionnaire evaluation (dullness / skin brightness)
FIG. 4 shows the results of a questionnaire evaluation of dullness / skin brightness. The numerical values in FIG. 4 indicate the scores (average values) of the five-level evaluation. As shown in FIG. 4, in the test group in which the processed barley leaf was ingested orally, the evaluation point of dullness / skin brightness was higher than in the comparative group. Further, in the test group, an increase in the evaluation score of dullness / skin brightness was observed 4 weeks and 8 weeks after ingestion as compared to before the ingestion. This suggests that orally ingesting a processed barley leaf product can improve skin dullness.

(Production Example of the Present Invention)
The oral moisturizing composition for skin, the oral composition for improving skin wrinkles, sagging or firmness, and the oral composition for improving skin dullness of the present invention can be used in various forms. For example, it can be used as a form of Production Examples 1 to 6 described below. It goes without saying that the embodiment of the present invention is not limited to the following.

(Production Example 1: Liquid)
Each component was blended at the ratio shown in Table 2 to produce a liquid preparation. By taking 5 to 400 mL of this liquid per day (the processed barley leaf intake is 0.1 to 8 g per day), the moisturizing effect of the skin is improved, and the wrinkle, sagging or firmness of the skin is improved. Or, it can be expected that the effect of improving skin dullness can be obtained.

(Production Example 2: Granules)
Each component was mixed so that it might become the ratio described in Table 3, and granulation was performed by fluidized bed granulation. The obtained granules were sieved with a 30-mesh sieve to obtain granules. By ingesting the present granules in an amount of 2 to 30 g per day (the amount of processed barley leaves is 0.5 to 7.5 g per day), the effect of improving moisturization of the skin, wrinkling, sagging or It can be expected that an effect of improving firmness or an effect of improving skin dullness can be obtained.

(Production Example 3: Liquid preparation)
Production Example 3 was prepared in the same manner as in Production Example 1 except that a dry powder of barley leaf juice was used instead of the barley leaf dry powder. By taking 5 to 400 mL of this liquid per day (the processed barley leaf intake is 0.1 to 8 g per day), the moisturizing effect of the skin is improved, and the wrinkle, sagging or firmness of the skin is improved. Or, it can be expected that the effect of improving skin dullness can be obtained.

(Production Example 4: Granules)
Production Example 4 was prepared in the same manner as in Production Example 2 except that dry powder of barley leaf juice was used instead of barley leaf dry powder. By ingesting the present granules in an amount of 2 to 30 g per day (the amount of processed barley leaves is 0.5 to 7.5 g per day), the effect of improving moisturizing skin, wrinkling, sagging or It can be expected that an effect of improving firmness or an effect of improving skin dullness can be obtained.

(Production Example 5: liquid agent)
Production Example 5 was prepared in the same manner as in Production Example 1 except that a dry powder of an aqueous extract of barley leaves was used instead of the barley leaf dry powder. By taking 5 to 400 mL of this liquid per day (the processed barley leaf intake is 0.1 to 8 g per day), the moisturizing effect of the skin is improved, and the wrinkle, sagging or firmness of the skin is improved. Or, it can be expected that the effect of improving skin dullness can be obtained.

(Production Example 6: Granules)
Production Example 6 was prepared in the same manner as in Production Example 2 except that a dry powder of an aqueous extract of barley leaves was used instead of the barley leaf dry powder. By ingesting the present granules in an amount of 2 to 30 g per day (the amount of processed barley leaves is 0.5 to 7.5 g per day), the effect of improving moisturizing skin, wrinkling, sagging or It can be expected that an effect of improving firmness or an effect of improving skin dullness can be obtained.

Claims (3)

An oral composition for moisturizing skin (excluding a composition containing collagen as an active ingredient) , characterized by containing a dry powder of barley leaves. An oral composition for improving skin firmness, which comprises a dry powder of barley leaves (excluding those containing collagen as an active ingredient) . An oral composition for improving skin elasticity, comprising a dry powder of barley leaves.