JP5997721B2 - Oral composition - Google Patents

Description

  The present invention relates to a moisturizing oral composition for skin, characterized by comprising a processed product of button-bow fu as an active ingredient.

  Fresh and moisturized skin has a plump and youthful impression. Therefore, it is very important to moisturize the skin for women who care about beauty. Therefore, various skin moisturizers have been developed to meet the demands of these women.

  As a skin moisturizer, for example, a moisturizer (see Patent Document 1) containing as an active ingredient one or more kinds of plants selected from Lilyaceae plants, or an extract thereof, is known. It has been. Also known are humectants for external preparations for skin (see Patent Document 2), which are derived from corn fiber and / or corn cob and contain an acidic oligosaccharide having a uronic acid residue in the molecule as an active ingredient.

  However, many of these moisturizers are external preparations that are applied to the skin. As a composition for improving the moisture retention of the skin by oral ingestion, for example, an internal use composition for moisturizing the skin containing fermented milk of kefir bacteria (see Patent Document 3) is known, but compared with an external preparation. And development is inadequate. Therefore, development of a new moisturizing oral composition has been demanded.

JP 2009-096753 A JP 2009-013087 A Japanese Patent No. 5048246

  In view of such circumstances, it is an object of the present invention to provide a moisturizing oral composition for skin, characterized in that a processed product of button bow fu as an active ingredient.

  As a result of intensive studies, the present inventors have found that a skin moisturizing effect can be obtained by orally ingesting a processed product of button fountain, and have completed the present invention.

  That is, the present invention relates to a skin moisturizing oral composition characterized by containing a processed product of button-bow-fu as an active ingredient.

  According to the present invention, the effect of moisturizing the skin can be obtained by ingesting the moisturizing oral composition of the skin, characterized in that the processed product of button-bow-fuu is used as an active ingredient. That is, the present invention can be used as an oral moisturizer.

Change in water content of stratum corneum by ingestion of processed button bowfish Change in water transpiration due to consumption of processed button-bowl

  Hereinafter, embodiments of the present invention will be described. In addition, this invention is not limited by description of the below-mentioned embodiment, A various change is possible within the range of description in a claim.

  Button bowfish (scientific name: Peucedanum japonicum) is a perennial plant belonging to the genus Amaranthus. Also known as long life grass, it grows naturally in Okinawa from the southern part of Kyushu.

  The skin moisturizing oral composition of the present invention uses button fountain as a raw material. The raw material only needs to contain button bow fu, and may be any part such as stem, leaf, flower, root, etc., or whole grass may be used. In addition, it is especially preferable that a foliage part is included from a viewpoint of improving a moisturizing effect. Further, the button bow used in the present invention is not particularly limited as long as it is usually available.

  In the present invention, the “processed button-bough” means a product processed by subjecting the button-bowl to processing such as drying, crushing, squeezing, and extraction. Not applicable to fresh leaves. Specifically, for example, dry powder of button fountain, fragmented button fountain and dried powder thereof, squeezed button fountain and dried powder thereof, extract of button fountain and dry powder thereof, and the like can be mentioned. In addition, in this invention, a powder shall include what was granulated by adding an excipient | filler etc. as needed.

  As a method for dry-powdering the button bow, dry powder can be obtained by a method commonly used by those skilled in the art, and a conventionally known method may be used. For example, there is a method in which the button bow is cut, followed by blanching treatment, then dried so that the water content is 10% by mass or less, preferably 5% by mass or less, and then pulverized. Further, there is a method in which the button bow is cut, followed by blanching treatment, then twisted, then dried and pulverized. Further, there is a method in which the button bow is dried, coarsely pulverized, heated at 110 ° C. or higher, and further finely pulverized (see Japanese Patent Application Laid-Open No. 2003-033151).

  As a method of slicing the button bow, it may be sliced by a method commonly used by those skilled in the art, and a conventionally known method may be used. For example, the method of fragmenting a plant body by slicing, shredding, etc. is mentioned. As an example of fragmentation, a slurry may be used. Slurry may be performed by a method in which the button bow is applied to a mixer, a juicer, a blender, a mass collider, etc., and the button bow is made into a bowl-like shape (liquid and solid suspension). Moreover, you may add water in the shape of a thick bowl as needed.

  As a method of drying the fragmented product of button-bow-fu, it may be dried by a method commonly used by those skilled in the art, and a conventionally known method may be used. Examples thereof include a method of drying in the sun, and a method of drying by spray drying, freeze drying, reduced pressure drying, fluidized drying and the like using a dryer.

  As a method of squeezing button bow fu, juice may be squeezed by a method commonly used by those skilled in the art, and a conventionally known method may be used. For example, the method of squeezing button bow fu or its fragmented product, the method of centrifuging or filtering the button bow fu fragmented product, and the like can be mentioned. Note that the juice may be concentrated as necessary. Moreover, you may use the squeeze residue which remains after performing a squeeze process from a button bow as a processed product of a button bow.

  As a method for dry pulverizing the button-bough squeezed product, a squeezed product may be dried and powdered by a method commonly used by those skilled in the art, and a conventionally known method may be used. For example, the juice may be dried and powdered as it is, or an appropriate binder or excipient may be added to the juice and dried to be powdered. Moreover, an excipient | filler etc. may be added as needed to the squeezed product or the dried powder of the squeezed product, and it may shape | mold and granulate by the granulation method of well-known wet and dry methods.

  As a method for extracting button bow, a method commonly used by those skilled in the art may be used, and a conventionally known method may be used. For example, a method of adding an extraction solvent usually used by those skilled in the art, such as ethanol, water, hydrous ethanol, etc. to button fountain or a fragmented product thereof, and heating and extracting as necessary. In addition, you may concentrate an extract as needed. In order to increase the concentration of the specific component, the extract may be fractionated by a method commonly used by those skilled in the art, or the specific component may be purified by a method commonly used by those skilled in the art. Moreover, you may use the extraction residue which remains after performing an extraction process from button-bough as a processed product of button-bowl.

  As a method for dry-pulverizing the extract of button fountain, the extract may be dry-powdered by a method commonly used by those skilled in the art, and a conventionally known method may be used. For example, the extract may be dried and pulverized, or an appropriate binder or excipient may be added to the extract and then dried to be pulverized. Moreover, an excipient | filler etc. may be added to an extract or the dry powder of an extract as needed, and it may shape | mold and pulverize to a granule by well-known wet granulation methods, such as a dry type.

  As described above, as the processed product of the button bow fungus of the present invention, any can be used as long as the button bow fungus has been subjected to some processing, but the dry powder of the button bow fungus has a high effect. It is particularly preferable to use dry powder of button bow.

  The processed button-bow-fu of the present invention may be sterilized by a method such as normal air sterilization, high-pressure sterilization, and heat sterilization.

  In the skin moisturizing oral composition of the present invention, the content of the processed processed product of button fountain is not particularly limited as long as it does not hinder the solution of the problems of the present invention, but for example, 0.1% by mass or more, preferably 0.5% It is at least mass%, more preferably at least 1 mass%, even more preferably at least 10 mass%, and most preferably at least 20 mass%.

  In the skin moisturizing oral composition of the present invention, the daily intake amount of the processed processed product of button fountain is not particularly limited, but if the intake amount is too small, the effects of the present invention may not be sufficiently exhibited. In this respect, the daily intake is preferably 0.1 g or more, more preferably 0.5 g or more, still more preferably 0.9 g or more, and most preferably 1.0 g or more. Moreover, the upper limit of the daily intake of the present invention is not particularly limited, but may be, for example, 20.0 g or less, 15.0 g or less, 8.0 g or less, or 7.5 g or less.

  The skin moisturizing oral composition of the present invention may contain an active ingredient in addition to the processed product of button fountain but does not contain any other active ingredient, and the effect of the present invention can be obtained even if only the processed product of button fountain is used as the active ingredient. It can be demonstrated. Therefore, the oral composition of this invention does not need to contain the raw material which has a moisturizing effect other than the processed product of button bow.

  The skin moisturizing oral composition of the present invention can be in any form using the processed product. As the form of the oral composition of the present invention, a form suitable for oral intake, for example, powder, granule, granule, tablet, rod, plate, block, solid, round, liquid, bowl, Examples include pastes, creams, capsules such as hard capsules and soft capsules, caplets, tablets, gels, jellies, gummi, wafers, chewables, syrups, sticks, and the like. When the oral composition of the present invention is in a solid form, it can be mixed with water, suspended or dissolved, and orally ingested as a liquid form. It may be taken orally as it is. Moreover, you may add not only to water but to liquids, such as tea and milk.

  The skin moisturizing oral composition of the present invention is not particularly limited in blending with other components, and components other than button fountain may be blended as necessary. Examples of components other than buttonfish include vitamins (A, C, D, E, K, folic acid, pantothenic acid, biotin, derivatives thereof, etc.), minerals (iron, magnesium, calcium, zinc, selenium, etc.), α-lipoic acid, lecithin, polyphenols (flavonoids, derivatives thereof, etc.), carotenoids (lycopene, astaxanthin, zeaxanthin, lutein, etc.), xanthine derivatives (caffeine, etc.), fatty acids, amino sugars (glucosamine, acetylglucosamine, galactosamine, Acetylgalactosamine, neuraminic acid, acetylneuraminic acid, hexosamine, salts thereof, oligosaccharide (isomalto-oligosaccharide, cyclic oligosaccharide, etc.), plant dry powder, animal and plant extracts, sulfur-containing compounds (alliin, sepaene, taurine, Glutathione, methyl sulfo Rumetan etc.), sugar alcohols, sugars, lignans (sesamin, etc.) and the like may be blended. In addition, acidulants such as citric acid, lactic acid, gluconic acid and apple, colorants such as titanium oxide, thickeners such as gum arabic and xanthan gum, sweeteners such as thaumatin and reduced maltose, brighteners such as shellac, talc, Manufacturing agents such as silicon dioxide, cellulose, calcium stearate, etc. may be blended, and various excipients, binders, lubricants, stabilizers, diluents, extenders, thickeners, emulsifiers, coloring A fragrance, a fragrance, an additive and the like may be blended. In addition, content of components other than button-up can be suitably selected according to the form etc. of the oral composition of this invention.

  Hereinafter, the present invention will be described in more detail with reference to examples. Needless to say, the scope of the present invention is not limited to the following examples.

(Example: Examination of the effect of oral intake of processed products of button bow fu)
In order to confirm whether or not the moisturizing effect was observed by orally ingesting the processed product of button bowfish, a double-blind parallel group test was performed by the following method.

(1) Test subjects Eighteen women aged 35 to under 55 who have symptoms or pimples due to dry skin were tested.

(2) Manufacture of test product or placebo product Test product or placebo product powder was manufactured according to the formulation shown in Table 1. Because the placebo product contains a colorant, the placebo product and the test product cannot be visually distinguished. In addition, it is thought that the starch, coloring agent, and fragrance | flavor contained in a placebo product do not affect the effect of this invention.

(3) Test method Eighteen test subjects were divided into two groups so that the skin moisture (cheek), skin moisture transpiration (cheek) and age in the pre-intake test were as equal as possible. Grouped. The test group was ingested with the test product, and the comparative group was ingested with 1 g once a day (0.9 g intake of processed button pea per day) for 8 weeks. In addition, the test product or the placebo product was orally ingested by dissolving in 100 mL of water or hot water.

(4) Evaluation method About the item described below, it measured before ingestion, 4 weeks after ingestion, and 8 weeks after ingestion. In addition, the measurement was performed after acclimatization for 20 minutes in an environment adjustment room (temperature 21 ° C. ± 1 ° C., humidity 50% ± 10%) in which temperature and humidity were controlled.

1) Corneal layer moisture content The left cheekbone apex was measured using a Corneometer (Corneometer CM825, manufactured by Curage-Khazaka) as a measuring instrument.

2) Amount of moisture transpiration A tevameter (Tewometer TM300, manufactured by Curage-Khazaka) was used as a measuring instrument, and the apex of the left cheekbone was measured.

(5) Results 1) Water content of stratum corneum FIG. 1 shows the amount of change in water content of the stratum corneum. The numerical values in FIG. 1 mean the amount of change (average value) based on the numerical values before ingestion. As shown in FIG. 1, in the test group that orally ingested the processed processed product, the horny layer moisture content of the skin was higher after 4 and 8 weeks of intake than the comparative group. In the test group, the horny layer water content of the skin tended to increase after 4 and 8 weeks of ingestion compared to before intake.

2) Amount of moisture transpiration Figure 2 shows the amount of change in the amount of moisture transpiration. The numerical values in FIG. 2 mean the amount of change (average value) based on the numerical values before ingestion. As shown in FIG. 2, in the test group that orally ingested the processed processed product, the amount of transpiration of the skin at 4 weeks and 8 weeks after the intake was lower than that of the comparative group. Further, in the test group, the moisture transpiration amount of the skin tended to decrease after 4 weeks and 8 weeks after the intake compared to before the intake.

  As described above, it was found that the oral water intake of button bow fu increases the amount of moisture in the stratum corneum of the skin and decreases the amount of moisture transpiration of the skin. From this, it was shown that button bowfish is useful as a moisturizing oral composition for skin.

(Production example of the present invention)
The skin moisturizing oral composition of the present invention can be used in various forms. For example, it can use as a form of manufacture examples 1-6 described below. Needless to say, embodiments of the present invention are not limited to the following.

(Production Example 1: Solution)
Each component was mix | blended in the ratio described in Table 2, and the liquid agent was manufactured. It can be expected that the effect of improving moisturization of the skin can be obtained by ingesting 5 to 400 mL of this liquid agent per day (ingestion amount of processed processed button bot per day of 0.1 to 8 g).

(Production Example 2: Granules)
Each component was mixed so that it may become the ratio described in Table 3, and it granulated by the fluidized-bed granulation. The obtained granulated product was sieved with a 30-mesh sieve to obtain granules. It can be expected that the moisturizing improvement effect of the skin can be obtained by ingesting 2 to 30 g of this granule per day (0.5 to 7.5 g of intake of processed product of button-bough per day).

(Production Example 3: Solution)
Production Example 3 was prepared in the same manner as in Production Example 1 except that the dried powder of the squeezed button bow (stems and leaves) was used in place of the dry powder of button bows (stems and leaves). It can be expected that the effect of improving moisturization of the skin can be obtained by ingesting 5 to 400 mL of this liquid agent per day (ingestion amount of processed processed button bot per day is 0.1 to 8 g).

(Production Example 4: Granules)
Production Example 4 was prepared in the same manner as in Production Example 2 except that the dried powder of the squeezed button bow (stems and leaves) was used in place of the dry powder of button bows (stems and leaves). It can be expected that the moisturizing improvement effect of the skin can be obtained by ingesting 2 to 30 g of this granule per day (0.5 to 7.5 g of intake of processed product of button-bough per day).

(Production Example 5: Solution)
Production Example 5 was prepared in the same manner as in Production Example 1 above, except that the dry powder of the water extract of button bow fu (stems and leaves) was used instead of the dry powder of button bows (stems and leaves). It can be expected that the effect of improving moisturization of the skin can be obtained by ingesting 5 to 400 mL of this liquid agent per day (ingestion amount of processed processed button bot per day is 0.1 to 8 g).

(Production Example 6: Granule)
Production Example 6 was prepared in the same manner as in Production Example 2 above, except that the dry powder of the water extract of Button Bow Fu (stems and leaves) was used instead of the dry powder of Button Bow (stems and leaves). It can be expected that the moisturizing improvement effect of the skin can be obtained by ingesting 2 to 30 g of this granule per day (0.5 to 7.5 g of intake of processed product of button-bough per day).

Claims (1)

An oral composition for reducing the amount of transpiration of skin, characterized by comprising a dry powder of button fountain as an active ingredient.