JP2006045213A - Oral composition containing specific quinic acid derivative - Google Patents

Abstract

<P>PROBLEM TO BE SOLVED: To provide the new uses of dicaffeoylquinic acid, dicaffeoylquinic acid derivatives, tricaffeoylquinic acid and tricaffeoylquinic acid derivatives, and to provide a combination of the substances with other preferable materials to expand the utilization ranges of the substances. <P>SOLUTION: This oral composition comprises at least one raw material selected from the group consisting of dicaffeoylquinic acid, dicaffeoylquinic acid derivatives, tricaffeoylquinic acid, and tricaffeoylquinic acid derivatives, a sugar alcohol, a guava leaf-processed product, and water-soluble edible fibers. <P>COPYRIGHT: (C)2006,JPO&NCIPI

Description

  The present invention relates to an oral composition containing a raw material containing a specific quinic acid derivative, a sugar alcohol, a processed guava leaf product, and water-soluble dietary fiber.

  Dicaffeoylquinic acid or tricaffeoylquinic acid is a conjugate in which two molecules or three molecules of caffeic acid are bound to one molecule of quinic acid. Examples of such a conjugate include 3,4-dicaffeoylquinic acid, 4,5-dicaffeoylquinic acid, 3,5-dicaffeoylquinic acid, 3,4,5-tricaffeoylquina. Examples include acids. These substances are known to have various physiological actions such as an antioxidant action (Patent Document 1).

Many of the above substances are used in the pharmaceutical field, but their use in fields other than medicine, such as the food field, has not been clarified. That is, although these substances are useful substances, they are not fully utilized. Therefore, new uses of these substances, for example, uses in the food field and the like are desired.
Japanese Patent Laid-Open No. 6-166681

  The object of the present invention is to provide new uses of dicaffeoylquinic acid, dicaffeoylquinic acid derivatives, tricaffeoylquinic acid, and tricaffeoylquinic acid derivatives, as well as combinations with other preferred materials. The purpose is to expand the range of use of these substances.

  The present inventor has already found that dicaffeoylquinic acid, tricaffeoylquinic acid, and sweet potato stems or leaves containing these components have an anti-diabetic effect such as an excellent blood glucose lowering effect. Yes. Furthermore, the combination of the food raw material and pharmaceutical raw material for exhibiting the effect | action which those components have more effectively was discovered.

  The present invention relates to a raw material containing at least one selected from the group consisting of dicaffeoylquinic acid, dicaffeoylquinic acid derivatives, tricaffeoylquinic acid, and tricaffeoylquinic acid derivatives, sugar alcohol, guava leaf processing And an oral composition containing water-soluble dietary fiber.

  In a preferred embodiment, the sugar alcohol is reduced maltose.

  The composition for oral use of the present invention can enhance the action of dicaffeoylquinic acid, tricaffeoylquinic acid, etc. by blending it into foods, pharmaceuticals, quasi drugs, etc. Anti-diabetic effects such as effects, anti-obesity effects and the like can be obtained.

  The oral composition of the present invention includes dicaffeoylquinic acid, dicaffeoylquinic acid derivatives, tricaffeoylquinic acid, and tricaffeoylquinic acid derivatives (hereinafter sometimes referred to as “specific quinic acid derivatives”). A raw material containing at least one selected from the group consisting of: sugar alcohol, processed guava leaves, and water-soluble dietary fiber. Hereinafter, the components of the oral composition of the present invention will be described individually. It should be noted that the present invention should not be construed as being limited to the following embodiments, and various modifications can be made within the scope of the claims.

(1) Raw material containing specific quinic acid derivative The raw material containing the specific quinic acid derivative used in the present invention is dicaffeoylquinic acid, dicaffeoylquinic acid derivative, tricaffeoylquinic acid, and Contains at least one tricaffeoylquinic acid derivative. These specific quinic acid derivatives are one type of polyphenol.

  As used herein, “dicaffeoylquinic acid” refers to a compound in which two molecules of caffeic acid or caffeic acid derivative are bound to one molecule of quinic acid or quinic acid derivative. For example, an ester of one molecule of quinic acid or a quinic acid derivative and two molecules of caffeic acid or a caffeic acid derivative can be mentioned. Examples of dicaffeoylquinic acid include 3,4-dicaffeoylquinic acid, 3,5-dicaffeoylquinic acid, 3,5-dicaffeoylquinic acid, and 4,5- Examples include dicaffeoylquinic acid (3,5-dicaffeoylquinic acid).

  The structural formula of 3,5-dicaffeoylquinic acid is in the following formula (A), the structural formula of 3,4-dicaffeoylquinic acid is in the following formula (B), and 4,5-dicaffeoyl oil The structural formula of quinic acid is shown in the following formula (C).

  In this specification, “tricaffeoylquinic acid” refers to a compound in which three molecules of caffeic acid or caffeic acid derivative are bound to one molecule of quinic acid or quinic acid derivative. For example, an ester of 1 molecule of quinic acid or a quinic acid derivative and 3 molecules of caffeic acid or a caffeic acid derivative can be mentioned. Examples of tricaffeoylquinic acid include 3,4,5-tricaffeoylquinic acid (3,4,5-tricaffeoylquinic acid). The structural formula of 3,4,5-tricaffeoylquinic acid is shown in the following formula (D).

  Examples of dicaffeoylquinic acid derivatives and tricaffeoylquinic acid derivatives include glycosides, salts, esters, succinyl groups of dicaffeoylquinic acid and tricaffeoylquinic acid, and the like. Examples include 3,5-dicaffeoyl-4-succinylquinic acid.

  The dicaffeoylquinic acid, dicaffeoylquinic acid derivative, tricaffeoylquinic acid, and tricaffeoylquinic acid derivative are, for example, sweet potato stems or leaves (hereinafter sometimes referred to as “sweet potato stems and leaves”), yacon stems and leaves , Coffee beans, mugwort foliage, tomato fruit, chrysanthemum foliage and other plants. Among these plants, especially sweet potato stover leaves contain dicaffeoylquinic acid and tricaffeoylquinic acid more than other plants. For example, a sweet potato leaf contains 1 mg / 100 g to 300 mg / 100 g of tricaffeoylquinic acid, or a polyphenol contained in a sweet potato stem and leaf contains the above-mentioned specific quinic acid derivative as compared with other plants. Many are included.

  Therefore, the raw material containing the specific quinic acid derivative used in the present invention is preferably a dry powder or juice from a plant body such as sweet potato foliage, yacon foliage, coffee beans, mugwort foliage, tomato fruit, or syringa foliage Examples thereof include an extract powder obtained by pulverizing a juice, an extract, or a substance separated and purified from these. Among these plants, sweet potato foliage is more preferably used because it contains both dicaffeoylquinic acid and tricaffeoylquinic acid as described above, and the plant yield is relatively high. Since sweet potato stems and leaves have a high content of a specific quinic acid derivative per dry mass of the plant body, it can be used as a dry powder as it is, and the action of the specific quinic acid derivative (for example, antidiabetic action, etc.) Can be fully demonstrated.

  Hereinafter, the raw material containing the specific quinic acid derivative used in the present invention will be specifically described taking sweet potato stems and leaves as an example.

  In the present specification, “sweet potato stem and leaves” refers to at least a part of stems and leaves that appear in the above-ground part of the cultivated sweet potato. Therefore, in the present invention, as the sweet potato stalk and leaf, only the above-ground sweet potato stalk may be used, only the sweet potato leaf may be used, or both the sweet potato stalk and leaf may be used.

  As the sweet potato stalks and leaves, it is preferable to use the stalks or leaves that appear in the above-ground part during cultivation of sweet potatoes. In particular, sweet potato stems and leaves grown to 10 cm or more, preferably 30 cm or more from the ground are preferable. Furthermore, when the length from the position where the candy stalk is exposed from the ground to the tip of the candy shoot is measured, the length is 300 cm or less, preferably 200 cm or less, more preferably 150 cm or less. It is better to use foliage. If it exceeds 300 cm, the tip of the sweet potato foliage comes into contact with the ground and is susceptible to harm from pests and the like, so that a sufficient amount of foliage may not be obtained. The obtained sweet potato stems and leaves are preferably processed after washing the adhering mud and the like with water.

  As the sweet potato foliage, it is more preferable to collect and use the sweet potato foliage at the tip of the sweet potato foliage and maintaining a green color compared to other foliage. The tip portion of this sweet potato stalk and leaf is particularly described as “sweet potato leaf shoot”. As the sweet shoots of sweet potato, the shoots and leaves of the portion within 40 cm from the tip of the sweet potato stem and leaf (hereinafter sometimes referred to as “specific sweet potato leaves”) are preferably used because they contain many specific quinic acid derivatives.

  The sweet potato leaves and specific sweet potato leaves are easy to process because the plants themselves are soft. When these are used as dry powders as they are, they are easy to use for various foods because of their good touch.

  The sweet potato stover can be dried as it is after harvesting into a dry powder. Alternatively, the sweet potato stover can be processed as needed. The processing is performed by at least one method selected from the group consisting of heat treatment, pressing, extraction, drying, and powdering treatment.

(Heat treatment)
The heat treatment is performed for the purpose of stabilizing the quality due to the inactivation of the enzyme in the sweet potato stalks and preventing the sweet potato stalks from being faded. Examples of the heat treatment include blanching treatment (blanching), dry heat treatment, microwave treatment, infrared and far infrared treatment, and steam treatment. Of these heat treatments, blanching treatment and steam treatment are preferably used. Furthermore, for the convenience of the treatment process, each treatment may be performed after cutting the sweet potato stems and leaves into a major axis of about 10 to 30 cm as necessary.

(Squeezed)
The pressing is performed using, for example, a pressing machine. As a result, squeezed sweet potato leaves are obtained. When using the obtained juice as it is for foods such as beverages, it is preferable to perform heat sterilization at 80 ° C to 130 ° C.

(Drying and powdering)
Drying is performed using any drying method commonly used by those skilled in the art after the sweet potato stover is left as it is or after being heated or squeezed into juice or paste. By performing the drying treatment, it is possible to preserve the plant body (sweet potato leaves) before processing such as extraction. Therefore, it is preferable to perform the drying treatment.

  Drying is performed according to the drying method, for example, hot air dryer, high pressure steam dryer, electromagnetic wave dryer, freeze dryer, vacuum concentrator, spray dryer, direct-fired heater, rotary draft dryer, etc. It is done using.

  Among these, for drying sweet potato stems and leaves, a hot air dryer, a direct-fired heater, and a rotary draft dryer are preferably used from the viewpoint of manufacturing cost and drying efficiency.

  When obtaining an extract powder, it is preferable to use a vacuum concentrator and a spray dryer. Spray drying is suitable as a method using squeezed sweet potato leaves as an extract powder. For example, the juice is pulverized using a spray dryer such as a spray dryer. When spray drying is performed, excipients such as dextrin, cyclodextrin, starch and maltose are added as necessary to increase the recovery rate. Preferably, dextrin is used, and the ratio of squeezed to dextrin is preferably 1:10 to 5: 1 in terms of mass ratio in order to facilitate powdering by addition of dextrin.

  Drying at normal pressure is preferably performed at 60 ° C. to 150 ° C., preferably 70 to 100 ° C., from the viewpoint of obtaining a sweet and colorful dried sweet potato stem powder. Drying under reduced pressure is preferably performed at 60 ° C. or lower, preferably at or above the temperature at which the sweet potato foliage, its paste or juice is frozen and at 60 ° C. or lower in terms of reducing loss of nutrient components.

  Drying is preferably performed so that the moisture content in the dried product or extract powder is 5% by mass or less.

  When the sweet potato leaves are dried as they are, it is preferable to dry them in two stages. The two-stage drying is performed using, for example, a hot air dryer. In the two-stage drying, first, primary drying is performed at a temperature of 60 to 80 ° C. until the water content of the sweet potato leaves becomes 25% by mass or less. Next, secondary drying is performed at a temperature higher than the primary drying until the moisture content of the primary dried sweet potato stover becomes 5% by mass or less. At this time, when the drying temperature of primary drying is less than 60 ° C., the drying speed is slow.

  The secondary drying temperature is preferably 100 ° C. or lower, more preferably 90 ° C. or lower, and further preferably about 80 ° C. By adjusting the temperature to about 80 ° C., a colorful sweet potato leaf powder with a high content of the specific quinic acid derivative can be obtained. When the drying temperature of secondary drying exceeds 100 ° C., it may cause scorching.

  In addition, it is preferable that the temperature difference of primary drying and secondary drying is about 5-15 degreeC, and it is more preferable that it is about 10 degreeC. For example, when secondary drying is performed at 90 ° C., the primary drying temperature is preferably 75 to 85 ° C., more preferably about 80 ° C.

  By performing this two-step drying process, the drying time is shortened, and at the same time, the green color and flavor of the sweet potato leaves are maintained. By setting the temperature difference within a certain range as described above, moisture management of the green leaves in the drying process is facilitated and drying is performed efficiently.

  The sweet potato stover obtained by the above drying can be pulverized as necessary. In particular, when a raw material for obtaining an extract (described later) is used, it is preferable to grind the sweet potato leaves from the viewpoint of increasing the extraction efficiency. For example, the dried sweet potato stalks and leaves are pulverized by using an apparatus or an instrument usually used by those skilled in the art, such as a cutter, a slicer, and a dicer. As for the size of the crushed sweet potato stem and leaves, the major axis is 20 mm or less, preferably 0.1 to 10 mm. In this way, a dry powder of sweet potato stover can be obtained.

  Heat treatment may be performed for the purpose of uniform heating and sterilization. By this heat treatment, the coarsely pulverized sweet potato foliage product can be heated uniformly, and efficient sterilization can be performed while improving the flavor of the sweet potato foliage. This heat treatment is performed at 110 ° C. or higher, and a high-pressure sterilizer, a heat sterilizer, a pressurized steam sterilizer, or the like can be used. In this heat treatment, the same effect can be obtained by treating the extract powder obtained from sweet potato stems and leaves in the same manner. Therefore, the extract powder may be heat-treated.

  The dried powder of sweet potato stover is preferably further pulverized. In the pulverization step, pulverization is performed so that 90% by mass passes through the 200 mesh section. The fine pulverization is performed using an apparatus or an instrument usually used by those skilled in the art, such as a crusher, a mill, a blender, and a stone mill. The texture is improved by fine grinding. Preferably, it goes through the steps of coarse pulverization, heating, and fine pulverization in order, so that it can be easily mixed uniformly when added to food.

(Extraction)
Extraction is performed by adding a predetermined solvent to the above-mentioned sweet potato stover or dry powder of sweet potato stover and maintaining for 10 minutes to 48 hours, preferably 30 minutes to 24 hours. The extraction temperature is 4 ° C. or higher, preferably 10 ° C. or higher, more preferably 25 ° C. or higher, most preferably 40 ° C. or higher, and 130 ° C. or lower, preferably 100 ° C. or lower.

  Examples of the solvent that can be used for extraction include water, an organic solvent, and a water-containing organic solvent. In this specification, the “water-containing organic solvent” is an organic solvent containing water, and the water and the organic solvent may be mixed or separated. Examples of the solvent that can be used for extraction include water; methanol, ethanol, 1-propanol, 2-propanol, 1-butanol, 2-butanol, acetone, hexane, cyclohexane, propylene glycol, ethyl methyl ketone, glycerin, methyl acetate, Organic solvents such as ethyl acetate, diethyl ether, dichloromethane, edible oils and fats, 1,1,1,2-tetrafluoroethane, 1,1,2-trichloroethene; and hydrous organic solvents containing water in these organic solvents Can be mentioned. Among these, it is preferable to use polar organic solvents such as water, ethanol and methanol, and hydrous organic solvents such as hydrous alcohols (hydrous ethanol and hydrous methanol).

  In particular, water or a water-containing polar organic solvent (water-containing alcohol, particularly water-containing ethanol or water-containing methanol) is preferable in that a specific quinic acid derivative can be efficiently extracted. In the case of efficiently extracting tricaffeoylquinic acid, it is more preferable to use hydrous ethanol containing ethanol in a proportion of 80% by volume to 10% by volume. More specifically, water-containing ethanol containing water or ethanol content in a proportion of 80% by volume or less is 0.5 parts by mass to 100 parts by mass, preferably 0.5 parts by mass to 1 part by mass of sweet potato stems and leaves. An extract is obtained by adding to 50 parts by mass and extracting at 10 ° C. to 100 ° C. for 10 minutes to 48 hours, preferably 30 minutes to 48 hours. When extracting in a short time, for example, in 30 minutes or less, it is preferable to extract using a dry powder or extract powder of sweet potato leaves.

  For example, 10 kg of water or 80% by volume of water-containing ethanol is added to 1 kg of dried sweet potato leaves and heated to reflux at 60 to 100 ° C. for 1 to 24 hours. And an extract can be obtained by filtration.

  The extract thus obtained may be further dried into powder, or may be purified to increase the content of a specific quinic acid derivative in the extract. As a purification method, for example, ethanol in the extract is removed by concentration under reduced pressure, and then adsorbed on a synthetic adsorbent (for example, Diaion HP20, Sepabeads, XAD4, etc.) and hydrous ethanol (for example, 10 to 80 volumes) % Water-containing ethanol) and a method of recovering from the synthetic adsorbent. Such an extract contains 0.01% by mass or more of tricaffeoylquinic acid and 0.1% by mass or more of dicaffeoylquinic acid in terms of dry mass before purification.

  Moreover, when using the plant body which contains water | moisture content in the ratio of 30 mass% or more like a tomato etc., it extracts by crushing a plant body with a mass collider etc., adding water, if necessary, and squeezing into juice. You can get things. In addition to the specific quinic acid derivative, the extract obtained in this manner contains solubilizing components of the plant body. Therefore, if necessary, a synthetic adsorbent (Diaion HP20, Sephabies SP825, Amberlite XAD4, MCIgelCHP20P, etc.), dextran resin (Sephadex LH-20, etc.) and the like are preferably purified by separation methods commonly used by those skilled in the art.

(2) Sugar alcohol In the present invention, sugar alcohol refers to a polyhydric alcohol obtained by reducing a carbonyl group of a sugar molecule. Examples of the sugar alcohol used in the composition of the present invention include erythritol, pentitol, hexitol, xylitol, sorbitol, reduced palatinose, reduced maltose (maltitol), lactitol, mannitol and the like. Of these, water-soluble sugar alcohols are preferred, and reduced maltose is more preferred.

  Reduced maltose is a water-soluble sugar alcohol made from starch. It is used as a sweetener for diabetics because it is hard to increase blood sugar level even when ingested and has lower calories than sugar.

  Since the oral composition of the present invention contains a sugar alcohol, it is easy to make a granulated product, and stability and palatability are also improved.

(3) Guava leaf processed product The processed guava leaf used in the oral composition of the present invention is a processed product of guava leaf, which is a plant of the Myrtaceae family, and contains polyphenols which are carbohydrate digestion absorption inhibiting components. Contains a lot. Examples of processed guava leaves used in the oral composition of the present invention include dried powder of guava leaves, juice, extract powder obtained by drying the juice, and guava leaf extract. Of these, guava leaf extract is preferred.

(4) Water-soluble dietary fiber Water-soluble dietary fiber used in the oral composition of the present invention includes pectin, guar gum, psyllium, galactomannan, xyloglucan, locust bean gum, glucomannan, sodium alginate, chondroitin sulfate, low Examples include molecular alginic acid, low molecular weight guar gum, indigestible dextrin, pullulan, fipalon, and chondroitin sulfate. Of these, indigestible dextrin is preferred.

  Indigestible dextrin is an indigestible polysaccharide obtained from starch. For example, starch is hydrolyzed by heating and then hydrolyzed by amylase. The indigestibility is derived from the α-1,4 bond of starch. Indigestible dextrin has an action to suppress blood sugar elevation after meals, as well as an action to improve blood lipids and an intestinal function. Indigestible dextrin is commercially available in the form of powder, fine granules, granules and the like, and any form can be used in the present invention. Since indigestible dextrin is water-soluble, it may be used in the form of an aqueous solution.

(5) Oral composition Since the oral composition of this invention contains the raw material containing a specific quinic acid derivative, sugar alcohol, guava leaf processed material, and water-soluble dietary fiber, it has the outstanding anti-diabetic action. . This is because (1) the insulin secretion promoting action and the insulin sensitivity enhancing action by the raw material containing the specific quinic acid derivative, and (2) the sugar digestion and absorption inhibiting action by the guava leaf processed product and the water-soluble dietary fiber. This is considered to be a natural effect. The composition of the present invention exhibits an effect superior to that obtained by simply combining a plurality of components having a sugar absorption inhibitory action. Furthermore, the oral composition of the present invention can provide an anti-obesity effect when ingested. The composition of the present invention may further contain dietary fiber, and thereby can be expected to improve constipation.

  The intake of the raw material containing the specific quinic acid derivative in the composition of the present invention is not particularly limited, but the daily intake for adults is 0.1 mg to 3000 mg as the total amount of the specific quinic acid derivative, preferably Is 1 mg to 1000 mg. What is necessary is just to mix | blend so that intake may be set to 0.1g-50g, Preferably it is 0.1-30g when using the dry powder of a sweet potato stem and leaf.

  The compounding amount of the raw material containing the specific quinic acid derivative in the oral composition of the present invention varies depending on the form and dosage form of the raw material, and can be adjusted as appropriate. In the case of a dry powder or extract powder of a plant body, it is preferably 0.0001 to 50 parts by mass, more preferably 0.001 to 30 parts by mass in 100 parts by mass of the oral composition. included. When using the dried powder of sweet potato stems and leaves, it is preferably contained in an amount of 0.01 to 80 parts by mass, more preferably 0.01 to 50 parts by mass.

  The compounding quantity of the sugar alcohol in the oral composition of this invention is not specifically limited. From the viewpoint of granulation and palatability, the amount of sugar alcohol is preferably 50 parts by mass to 200 parts by mass, more preferably 70 parts by mass with respect to 100 parts by mass of the dry mass of the raw material containing the specific quinic acid derivative. Part to 120 parts by mass.

  The compounding quantity of the guava leaf processed material in the oral composition of this invention is not specifically limited. For example, the guava leaf processed product (dry mass) is preferably 5 parts by mass to 100 parts by mass, more preferably 10 parts by mass to 50 parts by mass with respect to 100 parts by mass of the dry mass of the raw material containing the specific quinic acid derivative. It mix | blends so that it may become.

  The compounding quantity of the water-soluble dietary fiber in the oral composition of this invention is not specifically limited. From the viewpoints of granulation and palatability, water-soluble dietary fiber (dry mass) is preferably 50 parts by mass to 200 parts by mass, more preferably 100 parts by mass of dry mass of the raw material containing the specific quinic acid derivative. Is blended so as to be 70 parts by mass to 120 parts by mass.

  The oral composition of the present invention is mixed with other food ingredients as necessary, and shaped into granules, tablets, etc., depending on the application (for example, as a food, medicine or quasi drug). May be.

  Examples of other food ingredients include excipients, extenders, binders, thickeners, emulsifiers, colorants, flavors and other food ingredients, seasonings, and pharmaceutical ingredients. Specific examples include royal jelly, propolis, vitamins (A, C, D, E, K, folic acid, pantothenic acid, biotin, derivatives thereof, etc.), minerals (iron, magnesium, calcium, zinc, selenium, etc.), chitin Chitosan, lecithin, polyphenols (flavonoids, derivatives thereof, etc.), carotenoids (lycopene, astaxanthin, zeaxanthin, lutein, etc.), xanthine derivatives (such as caffeine), fatty acids, proteins (collagen, elastin, etc.), mucopolysaccharides ( Hyaluronic acid, chondroitin, dermatan, heparan, heparin, ketalan, salts thereof, amino sugar (glucosamine, acetylglucosamine, galactosamine, acetylgalactosamine, neuraminic acid, acetylneuraminic acid, hexosamine Their salts), oligosaccharides (isomalto-oligosaccharides, cyclic oligosaccharides, etc.), phospholipids and their derivatives (phosphatidylcholine, sphingomyelin, ceramides, etc.), sulfur-containing compounds (alliin, sepaene, taurine, glutathione, methylsulfonyl) Methane, etc.), sugar alcohol, lignans (sesamin, etc.), plant and animal extracts containing these, root vegetables (turmeric, ginger, etc.), green leaves of gramineous plants such as wheat leaves, green leaves of cruciferous plants such as kale Etc.

  The oral composition of the present invention can also be used in beverages containing the above other food ingredients, for example, plant fermented juice, vegetable juice (for example, carrot juice), plant extract, fruit juice, and the like. By including the composition of the present invention containing a specific quinic acid derivative, the palatability of these beverages can be improved, and the functionality or nutritional value can be increased. These beverages can be enhanced in sweetness by adding sugar solution, sugar alcohol, seasoning or the like.

  There is no particular limitation on the form of the oral composition of the present invention and the food containing the oral composition of the present invention, but if necessary, it may be a capsule such as a hard capsule or a soft capsule, a tablet, or a pill. Alternatively, it may be in the form of powder, granule, tea, tea bag, bowl or the like, or it may be in the form of a beverage as it is. Depending on these shapes or preferences, the oral composition of the present invention or the food containing the oral composition of the present invention may be eaten as it is, or may be taken in water, hot water, milk or the like. For example, it may be pulverized into a tea bag shape, and the ingredients may be leached before drinking.

  EXAMPLES Hereinafter, although this invention is demonstrated based on an Example, this Example is not intending limiting this invention.

(Preparation Example 1)
As a raw material containing a specific quinic acid derivative, sweet potato stover was prepared.

  1 kg of sweet potato stems and leaves were immersed in hot water (97 ° C.) adjusted to pH 8.0 for 1 minute for blanching treatment. Immediately after the blanching treatment, it was immersed in water at 20 ° C. and cooled. After cooling, it is dried with hot air, pulverized with a dicer so that the major axis is about 1 mm, sterilized with a pressure steam sterilizer, and then pulverized with a hammer mill to obtain 80 g of fine powder (sweet potato stem powder). It was.

  When the amount of polyphenol contained in the obtained sweet potato stalks and leaves was measured by the foreign thiocult method, it was found that 10 mg of polyphenol (1% by mass) was contained per 1 g.

(Production Example 1: Preparation of food)
The sweet potato stalks and leaves powder obtained in Preparation Example 1 (raw material containing a specific quinic acid derivative), sugar alcohol, guava leaf processed product, and water-soluble dietary fiber are mixed to obtain a food (foodstuffs 1 to 4, powder). Prepared. Reduced maltose for sugar alcohol, guava leaf extract for processed guava leaves (trade name: guavaphenone, Bizen Kasei Co., Ltd.), and indigestible dextrin for water soluble dietary fiber (trade names: pine fiber, Matsutani) Chemical Industry Co., Ltd.) was used. Table 1 shows prescriptions of foods 1 to 4.

(Reference Example 1: Evaluation of anti-diabetic effect)
About the foodstuffs 1-3 obtained by the said manufacture example 1, the antidiabetic effect was evaluated with the following method. The anti-diabetic effect was evaluated based on the blood glucose level increase inhibitory effect.

  Twenty-five 6-week-old male SD rats (Kudo Co., Ltd.) were acclimated for one week with a standard diet (MF, Oriental Yeast Co., Ltd.). After acclimation, streptozotocin was administered via the tail vein to a weight of 30 mg / kg. Four days after administration, blood was collected from the orbital vein, and the blood glucose level at the time of feeding was measured. Twenty animals with a blood glucose level of 200 mg / dL or more were selected and used as a type I diabetes model. Furthermore, these 20 animals were divided into 4 groups so that the average values of blood glucose levels were equivalent (431 to 433 mg / dL). Of these, three groups (test groups 1 to 3) were orally administered by gavage once daily for 7 days at 1000 mg / kg body weight. An appropriate amount of 0.5 v / v% Tween physiological saline was used as a medium for oral administration. The remaining 1 group (control group) rats received vehicle alone. During the test period, the rats of the test groups 1 to 3 and the control group were allowed to freely receive standard feed and water. Seven days after the start of the test, blood at the time of feeding was again collected, and the blood glucose level (mg / dL) in the blood was measured. The results (average value and standard deviation) are shown in Table 2.

  From the results in Table 2, the foods (food 1 and food 2) containing the raw material having dicaffeoylquinic acid and the like and guava leaf extract or indigestible dextrin contain only guava leaf extract and indigestible dextrin. It was found that it has a superior blood glucose level inhibitory effect, that is, an antidiabetic effect, compared to the combined food (food 3) and the control group.

(Example 1: Evaluation of diet effect)
About the food 2 and the food 4 prepared by the said manufacture example 1, the diet effect was evaluated with the following method.

  Ten volunteers who have tried dieting and have failed before were randomly divided into two groups of 5 people per group, and the weight of each volunteer was measured. A group of volunteers then ingested a solution of food 2 (3 g) dissolved in 200 mL of hot water at 70 ° C. and the other group of volunteers received food 4 (3 g) in 200 mL of hot water at 70 ° C. The solution dissolved in was ingested. Each volunteer ingested the beverage 3 times a day for 8 weeks. Volunteers were told that they did not need to limit their diet.

  The weight of each volunteer was measured the next day after the intake period, and the weight loss was calculated according to the following formula. With respect to the calculation results, an average value and a standard deviation were obtained. The results are shown in Table 3.

  Weight loss (kg) = weight before ingestion (kg) −weight after ingestion 8 weeks (kg)

  As shown in Table 3, when food 2 and food 4 were compared, the body weight of the volunteer was more decreased in food 4 that was the oral composition of the present invention. That is, it can be seen that the food 4 has an excellent anti-obesity action (diet effect).

  In addition, 8 out of 10 subjects who ingested food 4 complained of a change in physical condition that “the bowel movement was improved”, and it was found that these foods were also excellent in the effect of improving the bowel movement. It was.

(Preparation Example 2: Method for producing sweet potato stem and leaf extract)
1 kg of sweet potato stems and leaves were directly dried in hot air at 80 ° C., and the dried sweet potato stems and leaves were coarsely pulverized with a ball mill. Next, 10 L of water was added to the coarsely pulverized sweet potato stover and subjected to heating under reflux at 80 ° C. for 24 hours, followed by filtration to obtain an extract. Next, vacuum concentration was performed at 50 ° C. to obtain 20 g of extracted powder.

  When the amount of polyphenol in the extracted powder was measured in the same manner as in Preparation Example 1, it was found that the extracted powder contained 4% by mass of polyphenol.

(Production Example 2)
Tablets (200 mg per tablet) were produced using the following raw materials.

<Tablet ingredients> Compounding amount (% by mass)
Sweet potato stover dried powder obtained in Preparation Example 2
Guava leaf extract 2
Soy peptide 40
Chitosan 20
Crystalline cellulose 10
Sucrose ester 4
Trehalose 11
Reduced maltose 10
Silicon dioxide 1

(Production Example 3)
Granules were produced with the following blending ratio. Although it was the same compounding ratio as the food 4 of the said manufacture example 1, it was excellent in the granulation property to a granule.

<Ingredients of granule> Blending amount (% by mass)
Dry powder of sweet potato stover obtained in Preparation Example 30
Reduced maltose 29.8
Guava leaf extract 10
Indigestible dextrin 30
Vitamin B1 0.2

(Example 2)
About the granule obtained by the said manufacture example 3, the blood glucose level raise inhibitory effect was evaluated with the following method.

  15 6-week-old male SD rats (Kudo Co., Ltd.) were acclimated for 1 week with a standard diet (MF, Oriental Yeast Co., Ltd.). After acclimation, streptozotocin was administered via the tail vein to a weight of 30 mg / kg. Four days after administration, blood was collected from the orbital vein and the blood glucose level at the time of feeding was measured. Ten animals having a blood glucose level of 200 mg / dL or more were selected and used as a type I diabetes model. Furthermore, these 10 animals were divided into two groups so that the average values of blood glucose levels were equivalent (431 to 433 mg / dL). Of these, one group (referred to as test group) was orally administered by gavage once a day for 7 days at 1000 mg / kg body weight with the granules obtained in Production Example 5. An appropriate amount of 0.5 v / v% Tween physiological saline was used as a medium for oral administration. The remaining 1 group (control group) rats received vehicle alone. During the test period, the rats in the test group and the control group had free intake of standard food and water. Seven days after the start of the test, blood at the time of feeding was again collected, and the blood glucose level (mg / dL) in the blood was measured. The results (average value and standard deviation) are shown in Table 4.

  As shown in Table 4, raw materials containing a specific quinic acid derivative (sweet potato foliage dry powder), sugar alcohol (reduced maltose), processed guava leaves (guava leaf extract), and water-soluble dietary fiber (digestible dextrin) The blood glucose level of the rats of the test group administered with the granules containing) was lower than the blood glucose level of the rats of the control group. In addition, although a direct comparison was not possible, a sufficient blood glucose level lowering effect was observed as compared with the result of Reference Example 1. Therefore, it can be seen that the oral composition (granule) of the present invention exhibits an excellent effect of suppressing an increase in blood glucose level, that is, an antidiabetic effect. Furthermore, since the composition for oral administration (granule) of the present invention contains water-soluble dietary fiber (digestible dextrin), the effect of improving bowel movement can be expected.

  The oral composition of the present invention exhibits a diet effect and an inhibitory effect on an increase in blood glucose level. Thus, new uses for certain quinic acid derivatives, especially sweet potato stover, are provided. By combining with other materials, a more excellent diet effect and blood glucose level increase suppressing effect can be obtained, which is extremely useful.

Claims (2)

  Raw materials containing at least one selected from the group consisting of dicaffeoylquinic acid, dicaffeoylquinic acid derivatives, tricaffeoylquinic acid, and tricaffeoylquinic acid derivatives, sugar alcohols, processed guava leaves, and water An oral composition containing a natural dietary fiber.   The oral composition according to claim 1, wherein the sugar alcohol is reduced maltose.