JP2010180141A - Anti-allergic composition - Google Patents

Abstract

<P>PROBLEM TO BE SOLVED: To provide a natural material which can safely, inexpensively, simply and daily continuously be taken, has a remarkable anti-allergic action, and is effective for preventing and/or improving various allergic diseases, such as pollinosis, allergic conjunctivitis, bronchial asthma and atopic dermatitis. <P>SOLUTION: A composition for controlling production of IgE is characterized by containing a treated product of Cinnamomum camphora, Laurus nobilis L., Lindera umbellata, or Persea americana Mill.; and an anti-allergic composition and an anti-allergic drink or food each contains the same. <P>COPYRIGHT: (C)2010,JPO&INPIT

Description

  The present invention relates to an IgE production-suppressing composition characterized by containing a processed product of camphor, bay, black moji, or crocodile, and an antiallergic composition and antiallergic food / beverage product containing the same.

  Allergic diseases are one of the most common diseases in developed countries. Typical examples include hay fever, allergic conjunctivitis, bronchial asthma, atopic dermatitis and the like, and rheumatism, inflammatory bowel disease, drug allergy, food allergy and the like. Among these, the number of patients with hay fever and atopic dermatitis is increasing rapidly, which is a big social problem.

  Although allergic reactions are roughly classified into four types, from type I to type IV, many allergic diseases are considered to occur via type I allergy. The mechanism of action is complex, but is thought to be as follows. When IgE antibody binds to the surface of mast cells and basophils in blood and tissues, and when an allergen specific to this IgE antibody binds, a large amount of chemical mediators such as histamine are produced and released from the cell, Leukotrienes and the like are produced on the surface. These produced substances increase vascular permeability and cause edema and excessive secretion of nasal discharge, and contract the smooth muscle and cause contraction of the bronchi and the like. These effects appear as allergic symptoms.

  Currently, allergic symptoms can be improved by reducing the chances of contact with allergens such as pollen and house dust with a mask, goggles, air purifier, etc. Physical methods, such as the method to prevent, histamine that inhibits free histamine from binding to the receptor, steroids that suppress the inflammatory reaction, degranulation inhibitor or leukotriene synthesis inhibitor that has a cell membrane stabilizing action, etc. There are pharmacological methods such as a method of suppressing an allergic reaction with other antiallergic agents. However, it is extremely difficult to completely prevent contact with allergens, and anti-allergic agents often have side effects and have limitations in daily long-term application.

  On the other hand, instead of these drugs, attempts have been made to improve allergic symptoms by ingesting foods exhibiting anti-allergic effects. For example, foods supplemented with tea, perilla, β-glucan, etc. are known. It has been. However, although these foods have fewer side effects than pharmaceuticals, they have a limited allergy improvement effect and cannot be said to be sufficient, so far there has been no satisfactory one.

  Therefore, an antiallergic food that can be taken on a daily basis and that can effectively relieve allergic symptoms such as hay fever is desired.

  By the way, camphor trees are well known as evergreen trees belonging to the genus Nikkei of the camphor family, and attempts have been made to obtain functional components from plants of the camphor family. For example, Patent Document 1 discloses that a component extracted and purified from Nikkei suppresses degranulation of mast cells. However, mast cells are not only involved in allergies via IgE as described above, but also as an innate immunity, they recognize microorganisms and foreign substances via Toll-like receptors, etc., and protect against infection by degranulation. Therefore, there is a problem that if the degranulation of mast cells is suppressed nonspecifically, the function of innate immunity is impaired. In addition, in order to obtain an active ingredient from Nikkei, callus is obtained by aseptically culturing tissue from the plant body, and further subcultured and then extracted and purified, or the plant body is infected with a specific microorganism and cultured. It was necessary to generate roots and extract and purify from the cultured roots, and it was necessary to perform complicated manufacturing processes. Moreover, since the effect is weak when stem skin is used, it was necessary to use roots in order to obtain a highly effective extract. Furthermore, although a drug having an action of suppressing degranulation is used in clinical practice, it has a problem that it exhibits a preventive effect and takes a long period of 4 to 6 weeks to show the effect. Yes.

Japanese Patent Laid-Open No. 1-102027

  Therefore, it can be taken safely and inexpensively and easily on a daily basis, and has a remarkable antiallergic action, such as various allergic diseases such as hay fever, allergic conjunctivitis, bronchial asthma, atopic There is still a high demand for natural materials effective for prevention and / or improvement of dermatitis and the like.

  As a result of diligent research to solve the above-mentioned problems, the present inventors have found that a processed product of camphor, bay, black moji and crocodile, preferably a composition obtained by extracting them using an organic solvent, is applied to other plants. In comparison, the present invention showed extremely strong IgE lowering effects and was found to be useful for the prevention and / or improvement of various allergic diseases. And when camphor, bay, black moji and crocodile were used, it was found that a highly effective antiallergic composition can be easily obtained without performing complicated concentration and purification steps, and the present invention was completed.

That is, the present invention includes the following inventions.
(1) An IgE production-suppressing composition comprising a processed product of camphor, bay, black moji, or crocodile.
(2) The IgE production inhibitory composition according to (1), which contains an organic solvent extract of camphor, bay, black moji, or crocodile.
(3) The IgE production-suppressing composition according to (2), wherein the organic solvent extract is extracted using an alcohol solvent and / or an ester solvent.
(4) An antiallergic composition containing the IgE production-suppressing composition according to any one of (1) to (3).
(5) An antiallergic food, beverage, or cosmetic comprising the IgE production-suppressing composition according to any one of (1) to (3).

  According to the present invention, it can be safely and inexpensively and easily ingested on a daily basis, and has a remarkable antiallergic action, such as hay fever, allergic conjunctivitis, bronchial asthma, and atopic dermatitis. An antiallergic composition effective for prevention and / or improvement of allergic diseases is provided.

  Hereinafter, preferred embodiments of the present invention will be specifically described.

  In the present invention, suppression of IgE production refers to an action of suppressing the production of IgE antibody by B cells and an action of preventing, treating, reducing or alleviating various adverse effects caused by IgE antibody. In the present invention, antiallergic action means hay fever, allergic conjunctivitis, bronchial asthma, atopic dermatitis, rheumatism, inflammatory bowel disease, drug allergies, food allergies, and various harmful effects caused by IgE antibodies. Refers to the action of preventing, treating, reducing or alleviating Furthermore, it is released from mast cells and the like due to the reaction via IgE antibody, caused by excessive chemical mediator, contraction of smooth muscle, enhanced vascular permeability, neutrophil migration, platelet aggregation, etc. It also includes the action of preventing, treating, reducing or alleviating the reactions and the various symptoms induced thereby.

  The present invention is effective for the above-mentioned pathological conditions, symptoms and conditions caused by an excess of IgE antibody, and does not depend on an excess of IgE antibody. Chemical mediator antagonists (for example, antihistamines, etc.) and degranulation inhibitors in that they do not suppress innate immune reactions that occur in the body or chemical defenses that are released by IgE antibodies and that are caused by chemical mediators. It is superior to etc. Furthermore, the degranulation inhibitor cannot suppress leukotriene (LT) or prostaglandin D2 (PGD2) synthesized and released on the mast cell membrane, but the IgE production inhibitory composition is also effective for LT and PGD2. Suppression of PGD2 acts particularly effectively on allergic reactions associated with migration of Th2 cells, eosinophils, and basophils. In addition, since the reaction through the IgE antibody, which is an upstream reaction, can be suppressed in a series of allergic reactions, the prevention and treatment of allergic reactions is more effective, immediate and specific. It is also excellent in that it is possible. Therefore, it is expected to be particularly effective for diseases associated with a disease state with high IgE level in the blood (hyperIgEemia), such as allergic (atopic) diseases, parasitic infections, high IgE syndrome, and Wiskott-Aldrich syndrome. it can.

  The camphor tree used in the present invention refers to a camphor tree (scientific name: Cinnamomum camphora, camellia, camellia, aka Kus, Namjamonja) which is a plant belonging to the genus Nikkei. The bay tree used in the present invention refers to a bay tree (scientific name: Laurus nobilis L., laurel tree) which is a plant belonging to the genus Camphoraceae. The black moji used in the present invention refers to a black moji (scientific name: Lindera umbellata, black letters) which is a plant belonging to the genus Black mushroom. The crocodile used in the present invention refers to a crocodile (Scientific name: Persea americana Mill., Pear, avocado) that is a plant belonging to the genus Allenaceae.

  As an active ingredient of the IgE production inhibitory composition and the antiallergic composition of the present invention, camphor, bay bay, black moji or crocodile may be used as they are, or a processed product of these plants may be used. As the treatment, crushing treatment, pulverization treatment, heating treatment, drying treatment, extraction treatment, pressure treatment, enzyme treatment, decomposition treatment (for example, hydrolysis treatment), and combinations thereof can be employed. In the present invention, it is preferable to use an organic solvent extract of camphor, bay, black moji or crocodile as an active ingredient. Extraction using an organic solvent is advantageous because the effects of the present invention can be easily enhanced. As described above, the IgE production-suppressing composition and anti-allergic composition of the present invention can be easily prepared and have high effects, so that they are economically excellent.

  Hereafter, the manufacturing method of the organic solvent extract of camphor, bay, black moji or crocodile used for this invention is demonstrated in detail. Examples of plant parts used for extraction include leaves, stems, trunks, bark, fruits, flowers, roots, and the like. For camphor trees and bays it is preferred to use leaves, for black moji to use bark, and for crocodiles it is preferred to use fruits. Leaves, bark, and fruits are easy to collect, can be easily secured, and are softer than trunks, so they are easy to process and extract, which is economically preferable.

  The extraction method is not particularly limited, but the above-mentioned camphor, bay, black moji, or crocodile parts as they are or after being cut or crushed, dried, crushed after drying, squeezed and extracted juice, etc. in the extraction solvent Examples of the method include immersion, stirring or refluxing, and known methods such as supercritical fluid extraction.

  Specific examples of organic solvents that can be used for extraction include alcohols, lower alcohols such as methanol, ethanol, n-propyl alcohol, isopropyl alcohol, and n-butyl alcohol, and 1,3-butylene glycol. Alcohols that are liquid at room temperature such as polyhydric alcohols such as propylene glycol and glycerin; Examples of ester solvents include methyl acetate, ethyl acetate, butyl acetate, isobutyl acetate, propyl acetate, cellosolve acetate, and methoxyacetate. Examples of other organic solvents include ethers such as diethyl ether and propyl ether; ketones such as acetone and ethyl methyl ketone; hexane; and chloroform. These may be used alone or in combination of two or more. When combining, the extraction operation may be performed using a mixture of a plurality of solvents, or the extraction operation may be performed in multiple stages in order with different solvents. Among the above organic solvents, alcohols that are liquid at room temperature, for example, lower alcohol solvents having 1 to 4 carbon atoms, are preferably used from the viewpoints of operability, safety, and environmental performance, and extraction is highly active. From the viewpoint of obtaining a product, an ester solvent is preferably used. Further, an extract obtained by further extracting with an ester solvent what is extracted with an alcohol solvent is also preferable.

  Specific extraction methods include adding a plant to a room temperature or warmed solvent at normal pressure or under pressure, extracting the plant with immersion, stirring, shaking, extracting with refluxing in the solvent, etc. Can be mentioned. In this case, it is appropriate that the extraction temperature is 5 ° C. to the boiling point of the solvent or less, and the extraction time varies depending on the type of solvent used and the extraction conditions. Particularly, it is appropriate to set it to about 3 to 10 days. When performing extraction by refluxing, it is preferable to use a low-boiling solvent so that the plant extract does not undergo denaturation or thermal decomposition. Further, the extraction operation can also be performed by a supercritical fluid extraction method using carbon dioxide or the like.

  Next, the mixture containing the extract and the residue is subjected to filtration, centrifugation, or the like, if necessary, to remove the solid component as a residue to obtain an extract. The removed solid component can be used again for the extraction operation, and this operation may be repeated several times.

  The extract thus obtained may be used as it is, and further may be used as dried or powdered by a method such as concentration or freeze-drying or spray-drying, if necessary.

  The IgE production-suppressing composition and anti-allergic composition of the present invention are usually applied in the range of 0.001 to 10 g per day for an adult on the basis of the dry mass of a processed product of camphor, bay, black moji or crocodile. . In the case of oral administration, the general daily intake is 0.01 to 3 g. However, since the extract is particularly safe, the intake can be further increased. The daily intake may be taken once, but may be taken in several divided doses.

  Examples of the dosage form when the IgE production-suppressing composition and antiallergic composition of the present invention are used as pharmaceutical compositions include, for example, tablets, capsules, granules, powders, syrups, dry syrups, liquids, suspensions, etc. Oral preparations such as oral preparations, inhalants, suppositories, etc., ointments, creams, gels, external preparations for skin such as patches, drops, injections and the like. Of these, oral agents are preferred. From the viewpoint of safety, it is better to use the organic solvent extract in the form of camphor, gecko, black moji or crocodile as it is.

  Such dosage forms include additives commonly used in processed products of camphor, bay, black moji or crocodile which are active ingredients such as excipients, disintegrants, binders, lubricants, surfactants, alcohols. Water, a water-soluble polymer, a sweetener, a corrigent, a sour agent, etc. can be blended according to the dosage form and can be produced according to a conventional method. Liquid preparations such as liquids and suspensions may be dissolved or suspended in water or other appropriate medium immediately before taking. In the case of tablets and granules, the preparations may be prepared by well-known methods. The surface may be coated.

  The content of the processed product of camphor, bay, black moji or crocodile in the pharmaceutical composition varies depending on the dosage form, but is usually 0.001 to 99% by mass, preferably 0.01 to 80% based on the dry mass. It is desirable that the dosage is in a mass% range so that the daily dose can be controlled so that the above-mentioned daily intake for adults can be taken.

  When adding the IgE production suppression composition of this invention to food-drinks, the form in particular is not restrict | limited, The IgE production suppression composition of this invention can be mix | blended other than health food, functional food, food for specific health, etc. All food and drinks are included. Specifically, various preparation forms such as liquid foods such as tablets, chewable tablets, powders, capsules, granules, drinks, and enteral nutrients can be used. The food and drink in the form of a preparation can be produced in the same manner as the pharmaceutical composition. In addition, food and beverage products such as green tea, oolong tea and black tea drinks, soft drinks, jelly drinks, sports drinks, milk drinks, carbonated drinks, fruit juice drinks, lactic acid bacteria drinks, fermented milk drinks, powdered drinks, cocoa drinks, purified water, etc. Beverages, butter, jam, sprinkles, margarine spreads, mayonnaise, shortening, custard cream, dressings, breads, cooked rice, noodles, pasta, miso soup, tofu, milk, yogurt, soup or sauces, confectionery (e.g. (Biscuits, cookies, chocolate, candy, cake, ice cream, chewing gum, tablets) and the like.

  The food and drink according to the present invention also includes livestock, racehorses, feed for appreciation animals, pet food, and the like. Since the feed can be used in almost the same composition and form as the food and drink, the description regarding the food and drink in this specification can be applied to the feed as well.

  In addition to food and drink, other food materials used in the production of food and feed, various nutrients, various vitamins, minerals, amino acids, various fats and oils, various additives (for example, taste ingredients, sweeteners, acidity such as organic acids, etc.) And a surfactant, a pH adjuster, a stabilizer, an antioxidant, a dye, and a flavor) and the like, and can be produced according to a conventional method. Moreover, the food / beverage products which concern on this invention can also be manufactured by mix | blending the IgE production suppression composition of this invention with the food / beverage products normally eaten.

  In the food and drink according to the present invention, the content of the processed product of camphor, bay, black moji or crocodile varies depending on the form of the food or drink, but is usually 0.001 to 50% by mass, preferably based on the dry mass. It is 0.05-20 mass%, More preferably, it is the range of 0.1-5 mass%. The daily intake may be taken once, but may be taken in several divided doses. It is preferable that the intake amount per day can be managed so that the intake amount per day for an adult can be consumed.

  Since the IgE production-suppressing composition of the present invention has high safety, it can also be added to cosmetics. Since the cosmetic according to the present invention can be applied continuously, it is particularly effective for preventing and / or improving atopic dermatitis.

  When preparing the cosmetic according to the present invention, the processed product of camphor, bay, black moji or crocodile may be used as it is, or an organic solvent extract of camphor, bay, black moji or crocodile is formulated by a general-purpose method, Milky lotion, cosmetic liquid, cream, lotion, essence, pack and sheet, foundation, funny, blusher, lipstick, eye shadow, eyeliner, mascara, facial cleanser, skin cleanser, gel, gel, skin cleanser, body shampoo, etc. Cosmetics in the form of hair cosmetics such as shampoos, shampoos, rinses, hair cosmetics, hair treatments, hair nourishing agents, bath preparations, ointments, quasi-drugs, oil blotting paper, etc. may be prepared.

  The cosmetics according to the present invention include conventionally known excipients and perfumes, fats and oils, surfactants, preservatives, according to the desired dosage form, in addition to the processed products of camphor, bay, black moji or crocodile. A sequestering agent, a water-soluble polymer, a thickener, a powder component such as a pigment, a UV protection agent, a moisturizing agent, an antioxidant, a pH adjusting agent, a cleaning agent, a drying agent, an emulsifier, etc. Can be manufactured according to the law.

  The content of the processed product of camphor, bay, black moji or crocodile in the cosmetic according to the present invention is not particularly limited, but is usually 0.001 to 50% by mass, preferably 0.01 to 20% based on the dry mass. It is in the range of mass%.

  The IgE production-suppressing composition, antiallergic composition, food and drink, feed and cosmetics of the present invention can be combined with known antihistamine substances, antiallergic substances, and immunomodulating substances. Antihistamines include tea, perilla, bursa, polyphenols, diphenhydramine hydrochloride, diphenylpyraline hydrochloride, diphenylpyraline teolurate, clemastine fumarate, chlorpheniramine maleate, triprolidine hydrochloride, cyproheptadine hydrochloride, promethazine hydrochloride, alimemazine tartrate, Examples include dimene donato. Antiallergic substances include tea, green tea, perilla, oligosaccharide, lactic acid bacteria, amlexanox, ibudilast, cromoglycate sodium, tazanolast, tranilast, pemirolast potassium, repirinast, ebastine, azelastine hydrochloride, epinastine hydrochloride, olopatadine hydrochloride, cetirizine hydrochloride, Fexofenadine hydrochloride, levocabastine hydrochloride, oxatomide, ketotifen fumarate, emedastine fumarate, bepotastine pecylate, mequitazine, loratadine, ozagrel hydrochloride, seratrodast, ramatroban, zafirlukast, pranlukast hydrate, montelukast sodium, suplatast tosylate, etc. Can be mentioned. Examples of immunomodulators include arabinoxylan, lactic acid bacteria, β-glucan, ginger, IL-1α, IL-1β, IL-2, IL-3, IL-4, IL-5, IL-6, IL-7, IL- 8, IL-9, IL-10, IL-11, IL-12, IL-13, IL-15, IL-21, TGF-β, GM-CSF, M-CSF, G-CSF, TNF-α, Examples include TNF-β, LAF, TCGF, BCGF, TRF, BAF, BDG, MP, LIF, OSM, TMF, PDGF, IFN-α, IFN-β, IFN-γ, and the like.

  In addition to the above, the IgE production-suppressing composition, antiallergic composition, food and drink, feed and cosmetics of the present invention include, for example, conjugated linoleic acid, taurine, glutathione, carnitine, creatine, coenzyme Q, glucuronic acid, glucuronic acid. Chronolactone, pepper extract, ginger extract, cacao extract, guarana extract, garcinia extract, theanine, γ-aminobutyric acid, capsaicin, capsiate, various organic acids, flavonoids, polyphenols, catechins, xanthine derivatives, fructooligosaccharides, etc. Digestible oligosaccharides, polyvinylpyrrolidone, etc. may be blended.

  EXAMPLES Hereinafter, although this invention is demonstrated further in detail based on an Example, this invention is not limited to a following example.

(Example 1) Production of methanol extract of camphor tree Harvested camphor leaves (634 g) were washed and air-dried. Thereafter, it was further dried at 60 ° C. overnight. This was pulverized, immersed in 5 times the amount of methanol, and left to stand for 1 week for extraction. Thereafter, the insoluble matter was filtered through a filter paper (No. 2, Advantec Co. Ltd., Tokyo, Japan), and then concentrated and dried under reduced pressure to obtain 52.9 g of camphor methanol extract (yield: 8.84%).

(Example 2) Production of ethyl acetate extract of camphor tree Add 1 mL of distilled water to 0.27 g of methanol extract of camphor tree of Example 1, add 1 mL of ethyl acetate, and extract by shaking, and fractionate the ethyl acetate layer. did. This was repeated three times and the ethyl acetate layers were combined. This was concentrated with a centrifugal concentrator to obtain 46 mg of camphor ethyl acetate extract.

(Example 3) Manufacture of bay bay methanol extract Harvested bay leaves (15 g) were washed and air-dried. Thereafter, it was further dried at 60 ° C. overnight. This was pulverized, immersed in 5 times the amount of methanol, and left to stand for 1 week for extraction. Thereafter, the insoluble matter was filtered through a filter paper (No. 2, Advantec Co. Ltd., Tokyo, Japan), then concentrated under reduced pressure and dried to obtain 1.89 g of a bay bay methanol extract (yield: 12.6%).

(Example 4) Manufacture of methanol extract of Kuromoji Harvested barberry (15 g) was washed and air-dried. Thereafter, it was further dried at 60 ° C. overnight. This was pulverized, immersed in 5 times the amount of methanol, and left to stand for 1 week for extraction. Thereafter, the insoluble matter was filtered through a filter paper (No. 2, Advantec Co. Ltd., Tokyo, Japan), and then concentrated and dried under reduced pressure to obtain 0.99 g of a black extract methanol extract (yield: 6.6%).

(Example 5) Production of methanol extract of crocodile Harvest crocodile fruit (15 g) was washed and air-dried. Thereafter, it was further dried at 60 ° C. overnight. This was pulverized, immersed in 5 times the amount of methanol, and left to stand for 1 week for extraction. Thereafter, the insoluble matter was filtered through a filter paper (No. 2, Advantec Co. Ltd., Tokyo, Japan), and then concentrated and dried under reduced pressure to obtain 1.33 g of an alligator methanol extract (yield: 8.9%).

(Comparative example)
In the same manner as in Example 1, methanol extracts of pomegranate (Pomegranateaceae: Comparative Example 1), black cohosh (Ranunculaceae: Comparative Example 2) and cornflower mint (Lamiaceae: Comparative Example 3) were obtained.

(Test Example 1) IgE secretion inhibitory action U266 cells were cultured in RPMI 1640 (manufactured by SIGMA) supplemented with 10% of non-immobilized FBS. U266 cells were dispensed at a concentration of 3.5 × 10 ⁵ cells / mL into each well of a 96-well plate, to which Example 1 was 10, 30, 120 μg / mL, Example 2 was 2, 6, 24, 120 μg / mL and Examples 3 to 5 were diluted with DMSO and added to 120 μg / mL. After culturing at 37 ° C. for 4 hours, the culture supernatant was separated, and the amount of IgE antibody in the supernatant was measured using an IgE measurement kit (manufactured by the Institute of Medical Biology). As a positive target, a final concentration of 50 μmol / L of ammonium pyrrolidine dithiocarbamate (PDTC; manufactured by SIGMA) was used. The results are shown in Table 1 as relative values with the IgE amount of wells to which only DMSO as a solvent was added being 100.

(Test Example 2) IgE secretion inhibitory action Each sample of the comparative example was used at 120 μg / mL, and the test was performed in the same manner as in Test Example 1. The results are shown in Table 2 together with the results of the same concentration in the Example of Test Example 1.

(Example 6) Manufacture of tablets 40 g of methanol extract of camphor obtained in the same manner as in Example 1, 54 g of crystalline cellulose (Asahi Kasei) and 5 g of polyvinylpyrrolidone (BASF) were mixed, and 30 mL of ethanol was added thereto. Granules were produced according to a conventional method by a wet method. After the granules were dried, 1.2 g of magnesium stearate was added to obtain granules for tableting, and tableting was performed using a tableting machine to produce 100 tablets each having 1 g.

(Example 7) Manufacture of granule 100 g of methanol extract of chromoji obtained in the same manner as in Example 4, 100 g of lactose (DMV) and 40 g of crystalline cellulose (Asahi Kasei) were mixed, and 130 mL of ethanol was kneaded with this. And kneaded for 5 minutes by a conventional method. After kneading, the mixture was sieved with 10 mesh and dried at 50 ° C. in a dryer. After drying, the particles were sized to obtain 240 g of granules.

(Example 8) Manufacture of syrup agent While boiling 400 g of purified water, 750 g of white sugar and 10 g of the camphor methanol extract obtained in the same manner as in Example 1 were added and dissolved, and the cloth was heated when heated. Then, purified water was added thereto to make a total volume of 1000 mL to produce a syrup.

(Example 9) Manufacture of liquid foods 700 g of pure water at about 65 ° C., 40 g of sodium caseinate (DMV), 160 g of maltodextrin (Sanwa starch), and 5 g of methanol extract of bay bay obtained in the same manner as in Example 3. It was added and dissolved, and then each component mixture of vitamin mix and trace minerals was added. The obtained mixed solution was put into a homomixer and roughly emulsified at about 8,000 rpm for 15 minutes. The obtained emulsified liquid is cooled to about 20 ° C., and after adding a fragrance, the final mess up is carried out. Sterilization was performed to obtain a liquid food.

(Example 10) Manufacture of bread 163 g of wheat flour (strong flour) and 2 g of dry yeast were mixed. Separately, 0.4 g of a camphor methanol extract obtained in the same manner as in Example 1, 25 g of sugar, 3 g of sodium chloride, and 6 g of skim milk powder were dissolved in 70 g of hot water, and 1 chicken egg was added and mixed well. Add this to the above mixture of flour and dry yeast, knead by hand, knead well by adding about 40 g of butter, make 20 roll bread dough, then ferment these bread dough, Eggs were spread on and then baked in an oven at 180 ° C. for about 15 minutes to prepare a roll.

(Example 11) Manufacture of retort rice 0.1g of methanol mixture of commercially available mixed rice and camphor camphor obtained in the same manner as in Example 1 with respect to a general amount of water using 2 go rice In addition, the rice was cooked and filled in a retort pack according to a conventional method, and then sealed with nitrogen substitution, and sterilized at 121 ° C. for 15 minutes to obtain a rice litter.

(Example 12) Manufacture of sauce for pasta A portion (150 g) of meat sauce for pasta was put in a pan, and 0.1 g of camphor methanol extract obtained in the same manner as in Example 1 was added thereto, followed by warm mixing. did. After filling this pouch with a pouch, the pouch was sealed with nitrogen substitution and sterilized at 121 ° C. for 15 minutes to obtain a meat sauce for pasta.

(Example 13) Manufacture of vegetable juice A methanol extract of camphor tree obtained in the same manner as in Example 1 was added to and mixed with commercially available vegetable juice so as to be 0.5% by mass to prepare vegetable juice.

(Example 14) Manufacture of consomme soup Each slice of onion 100g, carrot 100g, long onion 100g, celery 50g, and tomato 100g was put in a pan, and here, ground beef 500g, egg white 2 pieces, beef bouillon 1kg , Boil over fire, reduce the fire, boil for 1 hour on low heat while removing acupuncture and fat floating on the surface, add 2 g of camphor methanol extract obtained in the same manner as in Example 1 Boiled for another 30 minutes and strained with a cloth to obtain a consomme soup.
(Example 15) Production of ointment

B is mixed while heating and dissolving at 70 ° C. to obtain an oil phase. A was mixed while being heated and dissolved at 70 ° C., and the oil phase of B was added thereto for mixing and emulsification. After that, the mixture was cooled and mixed well while adding C to obtain an ointment.
(Example 16) Production of cosmetic (milky lotion)

  A is mixed while heating and dissolving at 70 ° C. to obtain an oil phase. B is mixed while being heated and melted at 70 ° C., and the oil phase of A is added thereto, mixed and emulsified, and cooled to 50 ° C. Thereafter, while adding C, the mixture was well mixed and further cooled to obtain an emulsion.

Claims (5)

  An IgE production-suppressing composition comprising a processed product of camphor, bay, black moji or crocodile.   The composition for suppressing IgE production according to claim 1, comprising an organic solvent extract of camphor, bay, black moji or crocodile.   The IgE production suppression composition according to claim 2, wherein the organic solvent extract is extracted using an alcohol solvent and / or an ester solvent.   The antiallergic composition containing the IgE production suppression composition of any one of Claims 1-3.   The antiallergic food-drinks, feed, or cosmetics containing the IgE production suppression composition of any one of Claims 1-3.