JPH11246425A - Accelerator for decomposition of lipid and skin preparation for lean figure and for external use - Google Patents

Abstract

PROBLEM TO BE SOLVED: To obtain the subject accelerator having an action for stimulating the decomposition of lipid by including the extract of a Prerseae plant. SOLUTION: This accelerator for the decomposition of lipid comprises an extract obtained by extracting the fruit, pericarp or leaves of a Prerseae plant, preferably Persea americana belonging to the genus Machilus shearieri, Persea, with water or a hydrophilic organic solvent such as an alcohol and, if necessary, subsequently suitably subjecting the extract to concentration, purification, sterilization and/or drying treatments. When the accelerator is used for a skin preparation for external use, the extract is preferably added in an amount of 0.001-30.0 wt.% converted into the dry product. The addition of an ingredient selected from a xanthine derivative (for example, caffeine), a β-adrenaline action- accelerator (for example, isoproterenol), α 2-adrenaline action-inhibiting agent and a pyridine derivative (for example, yohimibine) to the extract gives a more excellent skin preparation for lean figure and for external use.

Description

DETAILED DESCRIPTION OF THE INVENTION

[0001]

The present invention relates to a lipolysis accelerator having an action of accelerating lipolysis and an external preparation for slimming skin using the lipolysis accelerator.

[0002]

2. Description of the Related Art Conventionally, in order to reduce excess fat in a body and maintain a firm body, in addition to various exercises and dietary restrictions, gels, creams and the like which promote metabolism in the body are conventionally used. It is known to use cosmetics, and such cosmetics and the like contain caffeine for the purpose of promoting lipolysis of fat cells constituting fat and having a slimming effect. Is a well-known fact. In addition to caffeine as a substance that promotes lipolysis, tea extracts and kola extracts are known as plant extracts, but none of them have a sufficient effect, and more effective lipolysis. The development of accelerators was desired.

[0003]

Means for Solving the Problems The present inventors have conducted intensive studies on a new component that promotes lipid degradation of adipocytes, and as a result, it has been found that an extract of a camphor tree plant (Perseae) has an excellent lipolysis promoting action. Xanthin derivatives, β-adrenergic stimulants, and
The present inventors have found that the addition of one or two or more selected from an α2 adrenergic action inhibitor and a bipyridine derivative can further enhance the lipolytic effect, and completed the present invention.

[0004] That is, the present invention is a lipolysis accelerator characterized by comprising an extract of a plant belonging to the family Leucaena (Perseae).

As the Perseae plants of the camphoraceae family used in the present invention, the genus Belischmiedia (Acacia catechu), the genus Machilus (Tabanoki), M.sheareri, Perse
a (Alligator, Avocado) genus. Machilus
Examples of the genus (Taunoki) include M. japonica (Blue oak) and M. thunbergii (Taunoki). M.shea
As the genus reri, Persea (crocodile, avocado), for example, P. americana (Americana), Mexican race (Mexico), Guatemaklan race (Guatemala), Indian
race (West Indies). These can be used alone or in combination of two or more. Among these, the genus M.sheareri, Persea (alligator, avocado) is preferable, and among them, avocado (P.americana (Americana)) is particularly preferable because of its excellent effect.

[0006] Such a camphor tree alligator ream (Perseae)
As the plant, mature or immature fruits, peels, seeds, leaves, petiole, branches, roots, flowers, etc. are used as raw materials, and among them, fruits, peels, and leaves are particularly preferable. The extraction method is not particularly limited, for example, water, a hydrophilic organic solvent such as alcohol, or a mixture thereof,
Alternatively, it is extracted with a polyhydric alcohol such as glycerin or 1,3-butylene glycol, or a mixed solution of water and a polyhydric alcohol. These may be used in the form of an extract, but may be used after being appropriately concentrated, purified, sterilized, dried, and the like.

The lipolysis promoter of the present invention is desirably used in the form of an external preparation. When used as an external preparation, the amount of the plant extract of the present invention in the external preparation is 0.001 to 30.0% by weight, preferably 0.01 to 1% by weight in terms of dry matter.
0.0% by weight. If the amount of the extract is less than 0.001% by weight, a sufficient lipolytic effect cannot be obtained, and if it exceeds 30.0% by weight, the lipolytic effect is not enhanced.

[0008] According to the present invention, there is provided an extract of a plant belonging to the family Leucaena (Perseae) and a xanthine derivative, β
There is provided a skin external preparation for slimming, comprising a mixture of one or more selected from an adrenergic stimulant, an α2 adrenergic inhibitor and a bipyridine derivative. By using an extract of a camphor tree (Perseae) plant and one or two or more selected from a xanthine derivative, a β-adrenergic action stimulant, an α2-adrenergic action inhibitor and a bipyridine derivative as an external preparation, An external preparation for slimming skin having an excellent decomposition effect can be obtained.

The xanthine derivatives used in the present invention include caffeine, theophylline, theobromine, xanthine, aminophylline, choline theophylline, zoprofylline, proxylphyrin and oxtriphline. These can be used alone or in combination of two or more. In the present invention, it is desirable to use one or a combination of two or more selected from the group consisting of caffeine, aminophylline, theophylline, and a pharmaceutically acceptable salt thereof, because the effect is excellent. As these xanthine derivatives, those which have been substantially purely isolated from plants such as synthetic or tea leaves can also be used.

[0010] The amount of the xanthine derivative to be incorporated into the external preparation for skin is preferably 0.001% by weight or more, particularly preferably 0.01 to 10.0% by weight.

The β-adrenergic stimulant used in the present invention is not particularly restricted but includes, for example, isoproterenol, epinephrine, norepinephrine, dobudamine, dobamine, butopamine, salbutamol, terbutaline, isoethalin, protokylol, fenoterol, metaproteline. Renol, chlorprenaline, hexoprenaline, trimethoquinol, procaterol hydrochloride, prenalterol, forskolin, disodium (R, R) -5- (2
-((2-((3-chlorophenyl) -2-hydroxyethyl) -amino) propyl-amino) propyl)-
1,3-benzoxol 2,2-dicarboxylate, (R, R) -4- (2-((2-((3-chlorophenyl) -2-hydroxyethyl) amino) propyl)
Phenyl) phenoxyacetic acid, (2-hydroxy-5-imidazol-2-yl) phenoxy) propyl) amino) ethoxy) benzamide monomethanesulfonate, erythro-DL-1- (7-methylindan-4-
(Iroxy) -3-isopropylaminobutan-2-ol and pharmaceutically acceptable salts thereof. These salts include, for example, pharmaceutically acceptable acid addition salts, metal salts, ammonium salts, organic amine addition salts,
Amino acid addition salts and the like. In the present invention, it is preferable to use one or more selected from the group consisting of isoproterenol, dobudamine, salbutamol and a pharmaceutically acceptable salt thereof, and in this case, the salt may be a hydrochloride or a sulfate. Is preferred.

The amount of the β-adrenergic stimulant added to the external preparation for skin is 0.005% by weight or more, especially 0.01 to 5% by weight.
Preferably, the content is 20.0% by weight.

The α2 adrenergic inhibitor used in the present invention is not particularly restricted but includes, for example, yohimbine, phentolamine, phenoxybenzamine, tolazoline, ergotamine, erotoxin, dihydroergotamine, ergomethrin, methylergometrine, dihydroergotoxin, laurosine, piperoxan. And pharmacologically acceptable salts thereof. These salts include:
The same thing as the above is mentioned. In the present invention, it is preferable to use one or two or more selected from the group consisting of yohimbine, phentolamine, ergotamine and a pharmaceutically acceptable salt thereof. Hydrochloride is preferred.

The content of the α2 adrenergic inhibitor in the external preparation for skin is 0.005% by weight or more, especially 0.01% by weight.
It is preferable to set it to ２20.0% by weight.

The bipyridine derivative used in the present invention is not particularly restricted but includes, for example, amrinone, milrinone, 5-cyano- (3,4-bipyridine) -6- (1H) -one and pharmaceutically acceptable salts thereof. And the like. Examples of these salts include those similar to the above. In the present invention, it is preferable to use one or more selected from the group consisting of amrinone, milrinone, and a pharmaceutically acceptable salt thereof.

The compounding amount of the bipyridine derivative in the external preparation for skin is 0.005% by weight or more, especially 0.01 to 20.0%.
It is preferable to set the weight%.

The external preparation for slimming skin of the present invention may contain various components generally used in cosmetics, pharmaceuticals, and the like, if necessary, as long as the effects of the present invention are not impaired. Such components include the following.

Vitamin A such as vitamin oil, retinol, retinol acetate, riboflavin, riboflavin butyrate,
Vitamin B ₂ such as flavin adenine nucleotide, pyridoxine hydrochloride, vitamin B ₆ such as pyridoxine dioctanoate, L- ascorbic acid, L- ascorbic acid Jiparuchimin ester, L- ascorbic acid -2
-Vitamin Cs such as sodium sulfate, L-ascorbic acid phosphate, DL-α-tocopherol-L-ascorbic acid diester dipotassium, calcium pantothenate, D-pantothenyl alcohol, pantothenyl ethyl ether, acetyl pantothenyl Pantothenic acids such as ethyl ether, ergocalciferol,
Vitamin Ds such as cholecalciferol, nicotinic acid,
Nicotinic acids such as nicotinamide and benzyl nicotinate; vitamin E agents such as α-tocopherol, tocopherol acetate, DL-α-tocopherol nicotinate, and DL-α-tocopherol succinate; vitamin P; vitamins such as biotin; Can be

Liquid oils and fats include avocado oil, camellia oil, evening primrose oil, turtle oil, macadamia nut oil, corn oil, mink oil, olive oil, rapeseed oil, egg yolk oil, sesame oil, persic oil, wheat germ oil, sasanqua oil,
Castor oil, linseed oil, safflower oil, cottonseed oil, eno oil,
Examples include soybean oil, peanut oil, teaseed oil, kaya oil, rice bran oil, sinagiri oil, Japanese kiri oil, jojoba oil, germ oil, triglycerin, glycerin trioctanoate, glycerin triisopalmitate, and the like.

Examples of solid fats and oils include cocoa butter, coconut oil, horse fat, hardened coconut oil, palm oil, tallow, sheep butter, hardened tallow, palm kernel oil, lard, beef bone oil, mocro kernel oil, hardened oil, Beef leg fat, mokuro, hardened castor oil and the like.

Examples of waxes include beeswax, candelilla wax, cotton wax, carnauba wax, bayberry wax, botaro wax, whale wax, montan wax, nuka wax, lanolin, kapok wax, lanolin acetate, liquid lanolin, sugar cane wax, isopropyl lanolin fatty acid, hexyl laurate, reduction Lanolin, Jojoba wax, hard lanolin, shellac wax, POE lanolin alcohol ether, PO
E Lanolin Alcohol Acetate, POE Cholesterol Ether, Lanolin Fatty Acid Polyethylene Glycol,
POE hydrogenated lanolin alcohol ethers and the like.

Examples of the hydrocarbon oil include liquid paraffin, ozokerite, squalene, pristane, paraffin, ceresin, squalene, petrolatum, microcrystalline wax and the like.

The higher fatty acids include, for example, lauric acid, myristic acid, palmitic acid, stearic acid, behenic (behenic) acid, oleic acid, 12-hydroxystearic acid, undecylenic acid, tallic acid, isostearic acid, linoleic acid, linoleic acid Acid, eicosapentaenoic acid (EPA), docosahexaenoic acid (DHA) and the like.

Examples of the higher alcohol include straight-chain alcohols such as lauryl alcohol, cetyl alcohol, stearyl alcohol, behenyl alcohol, myristyl alcohol, oleyl alcohol, and cetostearyl alcohol, monostearyl glycerin ether (bacyl alcohol), and 2-decyltetradecyl alcohol. And branched-chain alcohols such as knol, lanolin alcohol, cholesterol, phytosterol, hexyldecanol, isostearyl alcohol, octyldodecanol, and the like.

Examples of synthetic ester oils include isopropyl myristate, cetyl octoate, octyldodecyl myristate, isopropyl palmitate, butyl stearate, hexyl laurate, myristyl myristate,
Decyl oleate, hexyl decyl dimethyl octoate, cetyl lactate, myristyl lactate, lanolin acetate, isocetyl stearate, isocetyl isostearate,
Cholesteryl 2-hydroxystearylate, ethylene glycol di-2-ethylhexylate, fatty acid ester of dipentaerythritol, N-alkyl glycol monoisostearate, neopentyl glycol dicaprate, diisostearyl malate, glycerin di-2-heptylundecanoate Trimethylolpropane tri-2-ethylhexylate, trimethylolpropane triisostearate, pentaneerythritol tetra-2-ethylhexylate, glycerin tri-2-ethylhexylate, trimethylolpropane triisostearate, cetyl 2-ethylhexanoate, 2-ethylhexyl palmitate, glyceryl trimmyristate, tri-2-
Heptylundecanoic acid glyceride, castor oil fatty acid methyl ester, oleic oil, cetostearyl alcohol, acetoglyceride, 2-heptylundecyl palmitate, diisobutyl adipate, N-lauroyl-L-glutamic acid-2-octyldodecyl ester, adipic acid Di-2-heptylundecyl, ethyl laurate, di-2-ethylhexyl sebacate, 2-hexyldecyl myristate, 2-hexyldecyl palmitate, 2-hexyldecyl adipate, diisopropyl sebacate, 2-ethylhexyl succinate , Ethyl acetate, butyl acetate, amyl acetate, triethyl citrate and the like.

Examples of the silicone include linear polysiloxanes such as dimethylpolysiloxane, methylphenylpolysiloxane and methylhydrogenpolysiloxane, and cyclic polysiloxanes such as decamethylpolysiloxane, dodecamethylpolysiloxane and tetramethyltetrahydrogenpolysiloxane. Examples include polysiloxane, a silicone resin having a three-dimensional network structure, silicone rubber, and a solution of trimethylsiloxysilicate-octamethylcyclotetrasiloxane (50%).

Examples of humectants include polyethylene glycol, propylene glycol, glycerin, 1,3-
Butylene glycol, hexylene glycol, xylitol, sorbitol, maltitol, chondroitin sulfate, hyaluronic acid, mucoitin sulfate, caronic acid, atelocollagen, cholesteryl-12-hydroxystearate, sodium lactate, bile salts, dl-pyrrolidone carboxylate, Short-chain soluble collagen, adducts of diglycerin (EO) PO, extract of Iris osseum, extract of Achillea millefolium, extract of melilot and the like can be mentioned.

Examples of the ultraviolet absorber include para-aminobenzoic acid (hereinafter abbreviated as PABA), PABA monoglycerin ester, N, N-dipropoxy PABA ethyl ester, N, N-diethoxy PABA ethyl ester, N, N-diethoxy PABA ethyl ester
Benzoic acid ultraviolet absorbers such as N-dimethyl PABA ethyl ester and N, N-dimethyl PABA butyl ester; anthranilic acid ultraviolet absorbers such as homomenthyl-N-acetylanthranilate; amyl salicylate;
Salicylic acid ultraviolet absorbers such as menthyl salicylate, homomenthyl salicylate, octyl salicylate, phenyl salicylate, benzyl salicylate, p-isopropanol phenyl salicylate, octyl cinnamate, ethyl-4-isopropyl cinnamate, methyl-2,5-diisopropyl cinnamate , Ethyl-2,
4-diisopropylcinnamate, methyl-2,4-diisopropylcinnamate, propyl-p-methoxycinnamate, isopropyl-p-methoxycinnamate, isoamyl-p-methoxycinnamate, octyl-p-methoxycinnamate (2- Ethylhexyl-p
-Methoxycinnamate), 2-ethoxyethyl-p-
Methoxy cinnamate, cyclohexyl-p-methoxy cinnamate, ethyl-α-cyano-β-phenyl cinnamate, 2-ethylhexyl-α-cyano-β-phenyl cinnamate, glyceryl mono-2-ethylhexanoyl-diparamethoxy Cinnamate, cinnamic acid-based ultraviolet absorbers such as 3,4,5-trimethoxycinnamate 3-methyl-4- [methylbis (trimethylsiloxy) silyl] butyl and the like, 2,4-dihydroxybenzophenone, 2,2 ′
-Dihydroxy-4-methoxybenzophenone, 2,
2′-dihydroxy-4,4′-dimethoxybenzophenone, 2,2 ′, 4,4′-tetrahydroxybenzophenone, 2-hydroxy-4-methoxybenzophenone, 2-hydroxy-4-methoxy-4′-methylbenzophenone, 2-hydroxy-4-methoxybenzophenone-5-sulfonate, 4-phenylbenzophenone, 2-ethylhexyl-4′-phenyl-benzophenone-2-carboxylate, 2-hydroxy-4-n
Benzophenone-based ultraviolet absorbers such as -octoxybenzophenone, 4-hydroxy-3-carboxybenzophenone, 3- (4'-methylbenzylidene) -d, 1-camphor, 3-benzylidene-d, 1-camphor, urocanic acid, Urocanic acid ethyl ester, 2-phenyl-5-methylbenzoxazole, 2,2′-hydroxy-5-methylphenylbenzotriazole, 2- (2 ′
-Hydroxy-5'-t-octylphenyl) benzotriazole, 2- (2'-hydroxy-5'-methylphenylbenzotriazole, dibenzarazine, dianisoylmethane, 4-methoxy-4'-t-butyldibenzoylmethane, 5- (3,3-dimethyl-2-norbornylidene) -3-pentan-2-one and the like.

Examples of the anionic surfactant include soap base, fatty acid soaps such as sodium laurate and sodium palmitate, higher alkyl sulfates such as sodium lauryl sulfate and potassium lauryl sulfate, POE lauryl sulfate triethanolamine, PO
E Alkyl ether sulfates such as sodium lauryl sulfate; N-acyl sarcosine acids such as sodium lauroyl sarcosine; sodium N-myristoyl-N-methyltaurine; higher fatty acids such as sodium coconut fatty acid methyl tauride and sodium lauryl methyl tauride. Amidosulfonic acid salts, phosphate salts such as POE sodium oleyl ether phosphate, POE stearyl ether phosphoric acid, sodium di-2-ethylhexylsulfosuccinate, sodium monolauroyl monoethanolamide polyoxyethylene sulfosuccinate, lauryl polypropylene glycol sulfosuccinate Sulfosuccinates such as sodium, sodium linear dodecylbenzenesulfonate, triethanolamine linear dodecylbenzenesulfonate Alkylbenzenesulfonates such as linear dodecylbenzenesulfonic acid, monosodium N-lauroylglutamate, disodium N-stearoylglutamate, N-acylglutamate such as monosodium N-myristoyl-L-glutamate, and hydrogenated coconut oil fatty acid sodium glycerin sulfate Sulphate oils such as funnel oils, sulfated oils such as funnel oils, PO
E alkyl ether carboxylic acid, POE alkyl allyl ether carboxylate, α-olefin sulfonate,
Higher fatty acid ester sulfonate, secondary alcohol sulfate, higher fatty acid alkylolamide sulfate, sodium lauroyl monoethanolamidosuccinate, N-palmitoyl aspartate ditriethanolamine, sodium caseinate and the like.

Examples of the cationic surfactant include alkyltrimethylammonium salts such as stearyltrimethylammonium chloride and lauryltrimethylammonium chloride, distearyldimethylammonium dialkyldimethylammonium chloride, and poly (N, N'-dimethyl-3,3,3,4-dimethyl-3,3,4-dimethyl-3,3-dimethyl-3,3,4-dimethyl-3,3,4-dichloroammonium). Alkylpyridinium salts such as 5-methylenepiperidinium) and cetylpyridinium chloride, alkyl quaternary ammonium salts, alkyldimethylbenzylammonium salts, alkylisoquinolinium salts, dialkylmorphonium salts, POE alkylamines, alkylamine salts, Examples thereof include polyamine fatty acid derivatives, amyl alcohol fatty acid derivatives, benzalkonium chloride, benzethonium chloride and the like.

Examples of the amphoteric surfactant include 2-undecyl-N, N, N- (hydroxyethylcarboxymethyl) -2-imidazoline sodium and 2-cocoyl-2-imidazolinium hydroxide-1-carboxyethyl. Imidazoline amphoteric surfactants such as roxy disodium salt, 2-heptadecyl-N-carboxymethyl-
N-hydroxyethyl imidazolinium betaine, lauryl dimethylamino acetate betaine, alkyl betaine,
Betaine-based surfactants such as amidobetaine and sulfobetaine are exemplified.

Examples of the lipophilic nonionic surfactant include sorbitan monooleate, sorbitan monoisostearate, sorbitan monolaurate, sorbitan monopalmitate, sorbitan monostearate, sorbitan sesquioleate, sorbitan trioleate, Sorbitan fatty acid esters such as penta-2-ethylhexyl diglycerol sorbitan, tetra-2-ethylhexyl diglycerol sorbitan, mono-cottonseed oil fatty acid glycerin, glycerin monoerucate, glycerin sesquioleate, glyceryl monostearate, α,
Glycerin polyglycerin fatty acids such as α'-oleic acid glycerol pyroglutamate, glyceryl monostearate, propylene glycol fatty acid esters such as propylene glycol monostearate, hydrogenated castor oil derivatives, glycerin alkyl ether, polyoxyethylene methyl And polysiloxane copolymers.

Examples of the hydrophilic nonionic surfactant include POE sorbitan fatty acid esters such as POE sorbitan monooleate, POE-sorbitan monostearate, POE-sorbitan monooleate, POE-sorbitan tetraoleate, and POE-sorbitan. Sorbit Monolaurate, POE-Sorbit Monooleate, POE
-POE sorbitol fatty acid esters such as sorbit pentaoleate and POE-sorbit monostearate, POE glycerin fatty acid esters such as POE-glycerin monostearate, POE-glycerin monoisostearate and POE-glycerin triisostearate; POE monooleate, POE distearate,
POE fatty acid esters such as POE monodioleate and ethylene glycol cysteate, POE lauryl ether, POE oleyl ether, POE stearyl ether, POE behenyl ether, POE alkyl ethers such as POE2-octyldodecyl ether, POE cholestanol ether, POE octyl POE alkyl phenyl ethers such as phenyl ether, POE nonyl phenyl ether and POE dinonyl phenyl ether; pluronic type such as bruronic;
POE / POP alkyl ethers such as POP cetyl ether, POE / POP2-decyltetradecyl ether, POE / POP monobutyl ether, POE / POP hydrogenated lanolin, POE / POP glycerin ether, and tetraPOE / tetraPOP ethylenediamine such as Tetronic Condensates, POE castor oil, POE hardened castor oil, POE hardened castor oil monoisostearate,
POE-cured castor oil triisostearate, POE-cured castor oil monopyroglutamic acid monoisostearate diester, POE-casted oil-cured castor oil derivatives such as POE-cured castor oil maleic acid, POE beeswax lanolin derivatives such as POE sorbitol beeswax, coconut oil Fatty acid diethanolamide, lauric acid monoethanolamide,
Alkanolamides such as fatty acid isopropanolamide, POE propylene glycol fatty acid ester, PO
E alkylamine, POE fatty acid amide, sucrose fatty acid ester, POE nonylphenylformaldehyde condensate, alkylethoxydimethylamine oxide, trioleyl phosphoric acid and the like.

As amino acids, glycine, alanine,
Valine, leucine, isoleucine, phenylalanine,
Examples include tyrosine, threonine, serine, proline, hydroxyproline, tryptophan, methionine, cystine, aspartic acid, arginine, glutamic acid, glutamine, lysine, arginine, histidine and the like.

In addition, preservatives such as ethylparaben and butylparaben, anti-inflammatory agents such as glycyrrhizic acid derivatives, glycyrrhetinic acid derivatives, salicylic acid derivatives, hinokitiol, zinc oxide and allantoin; Oubak, Ouren,
Chicken, peonies, assembly, birch, sage, loquat, carrot, aloe, mallow, iris, grape, yokuinin, loofah, lily, saffron, senkyu, ginger, chrysanthemum, ononis, garlic, capsicum, chimpi, touki, seaweed, etc. Extract, royal jelly, photosensitizer, cholesterol derivative, activator such as juvenile blood extract, nonylate valenylamide, nicotinic acid benzyl ester, nicotinic acid β-butoxyethyl ester, capsaicin, zingerone, canthalis tincture, ictamol, tannic acid, α-borneol, tocopherol nicotinate, inositol hexanicotinate, cyclandate, cinnarizine, tolazoline,
There are blood circulation promoters such as acetylcholine, verapamil, cepharanthin, γ-oryzanol, antiseborrheic agents such as sulfur and thiantol, tranexamic acid, trimethylglycine, thiotaurine and hypotaurine.

Examples of natural water-soluble polymers include, for example, gum arabic, tragacanth, galactan, guar gum, carob gum, karaya gum, carrageenan, pectin, agar, quince seed (quince), alge colloid (cassow extract), starch (rice, corn) , Potato, wheat), plant polymers such as glycyrrhizic acid, microbial polymers such as xanthan gum, dextran, succinoglucan, pullulan, collagen,
Animal-based polymers such as casein, albumin, and gelatin are exemplified.

As the semi-synthetic water-soluble polymer, for example,
Starch-based polymers such as carboxymethyl starch and methylhydroxypropyl starch, methylcellulose, nitrocellulose, ethylcellulose, methylhydroxypropylcellulose, hydroxyethylcellulose, cellulose sodium sulfate, hydroxypropylcellulose, sodium carboxymethylcellulose (CM
C), cellulosic polymers such as crystalline cellulose and cellulose powder, and alginic acid polymers such as sodium alginate and propylene glycol alginate.

Examples of the synthetic water-soluble polymer include vinyl polymers such as polyvinyl alcohol, polyvinyl methyl ether, polyvinylpyrrolidone, and carboxyvinyl polymer (Carbopol);
000, 4,000,000, 600,000 and other polyoxyethylene polymers, polyoxyethylene polyoxypropylene copolymer copolymer polymers, sodium polyacrylate, polyethyl acrylate, polyacrylamide, etc. Acrylic polymer, polyethylene imine,
And cationic polymers.

Examples of the inorganic water-soluble polymer include bentonite, silicic acid A1Mg (Vegum), laponite,
Hectorite, silicic anhydride and the like.

Examples of the thickener include gum arabic, carrageenan, karaya gum, tragacanth gum, carob gum, quince seed (quince), casein, dextrin, gelatin, sodium pectate, sodium alginate, methylcellulose, ethylcellulose, C
MC, hydroxyethylcellulose, hydroxypropylcellulose, PVA, PVM, PVP, sodium polyacrylate, carboxyvinyl polymer, locust bean gum, guar gum, tamarind gum, dialkyldimethylammonium cellulose sulfate, xanthan gum, aluminum magnesium silicate, bentonite,
Hectorite and the like.

Examples of the powder component include talc, kaolin, mica, sericite, sericite, muscovite, phlogopite, synthetic mica, biotite, biotite, lithic mica, vermiculite,
Magnesium carbonate, calcium carbonate, aluminum silicate, barium silicate, calcium silicate, magnesium silicate, strontium silicate, metal tungstate, magnesium, silica, zeolite, barium sulfate, calcined calcium sulfate (calcium gypsum), calcium phosphate, Fluoroapatite, hydroxyapatite, ceramic powder, metal soap (zinc myristate, calcium palmitate, aluminum stearate), inorganic powder such as boron nitride, polyamide resin powder (nylon powder), polyethylene powder, polymethyl methacrylate powder, polystyrene Powders, organic resin powders such as styrene and acrylic acid copolymer resin powder, benzoguanamine resin powder, polytetrafluoroethylene powder, cellulose powder, etc., and inorganic white such as titanium dioxide, zinc oxide, etc. Fee, iron oxide (red iron oxide),
Inorganic red pigments such as iron titanate, inorganic brown pigments such as γ-iron oxide, yellow iron oxide, inorganic yellow pigments such as loess black iron oxide, carbon black, inorganic black pigments such as lower titanium oxide, Inorganic purple pigments such as mango violet and cobalt violet; inorganic green pigments such as chromium oxide, chromium hydroxide and cobalt titanate; inorganic blue pigments such as ultramarine blue and dark blue; titanium oxide coated mica; titanium oxide coated bismuth oxychloride , Titanium oxide coated talc, colored titanium oxide coated mica, bismuth oxychloride, pearl pigments such as fish scale foil, aluminum powder,
Metal powder pigments such as copper powder, Red No. 201, Red No. 202, Red No. 204, Red No. 205, Red 220
No. Red 226, Red 228, Red 405, Orange 203, Orange 204, Yellow 205, Yellow 401
No. 3, and organic pigments such as Blue No. 404, Red No. 3, Red No. 104, Red No. 106, Red No. 227, Red No. 230
No. Red No. 401, Red No. 505, Orange No. 205, Yellow No. 4, Yellow No. 5, Yellow No. 202, Yellow No. 203, Green No. 3
And organic pigments such as zirconium, barium or aluminum lakes such as No. 1 and Blue No. 1, natural pigments such as chlorophyll and β-carotene, and fragrances, water, alcohols, coloring agents such as titanium yellow, carsamin, and safflower red. It can be appropriately compounded depending on the situation.

The dosage form of the external preparation for skin of the present invention is arbitrary. For example, the dosage form may be an oily preparation, a solubilizing system for a lotion, an emulsifying system such as an emulsion or a cream, or an ointment, a dispersion or a powder. be able to.

[0043]

Next, the present invention will be described in more detail by way of examples. Note that the present invention is not limited to this. The compounding amount is% by weight. Prior to the examples, the effects of the present invention will be shown by experimental data.

(1) Lipolytic effect [Evaluation method] Isolation of adipocytes from adipose tissue was performed using Rodbel
According to the method of l (M. Rodbell, JBC, 239 (2), 1964).
The human adipose tissue obtained by liposuction is sliced into 2-3 mm pieces, and a 0.05% collagenase solution (Bank's buffer,
Contains 4% glucose. ) Incubation (3)
7 ° C, 45-60 minutes). Thereafter, the mixture was filtered to remove undigested adipose tissue, and centrifuged (1000 rpm, 1 rpm).
Minutes). Adipocytes have a specific gravity of less than 1 and float on top. The lower layer solution was removed, and a culture solution (199 medium, containing 10% newborn calf serum) was added and redispersed. Centrifugation and medium addition were repeated twice to remove collagenase.
Finally, 30 ml of the sample shown in Table 1 was added, and the cells were dispersed. In each sample, the avocado extract was 5.0% by weight, and caffeine, norepinephrine, phentolamine and amrinone were 0.1% by weight. The lipid content of adipocytes before and after the culture was quantified using Triglyceride-Test Wako (color reagent for lipid quantification, manufactured by Wako Pure Chemical Industries, Ltd.), and the amount of decomposed lipid (mg / tube) was determined.
Was measured. Table 1 shows the experimental results. The avocado extract was prepared by adding 500 ml of water to 500 g of the finely cut pieces,
For 60 minutes. After cooling, the mixture was naturally filtered with a filter paper, and water was added to make a total volume of 500 ml.

[0045]

[Table 1] ──────────────────────────────── Sample amount of decomposed lipid (mg / tube) ───── ─────────────────────────── Not added 0.35 ± 0.07 Avocado extract 0.34 ± 0.09 Caffeine 1.69 ± 0.15 Norepinephrine 1.74 ± 0.20 Phentolamine 1.50 ± 0.12 amrinone 1.45 ± 0.08 avocado extract + caffeine 2.33 ± 0.18 avocado extract + norepinephrine 2.45 ± 0.20 avocado extract + phentolamine 2.20 ± 0.25 avocado extract + amrinone 2.10 ± 0.15 ──────────── ────────────────────

From Table 1, it can be seen that the addition of the avocado extract and caffeine in combination promotes lipid degradation.

(2) Effect of promoting lipid metabolism [Evaluation method] 50 out of 90 women in their 20s and 30s were applied with the cream of Example 1 described later on the face and the whole body in the morning and evening, and used continuously for 3 months. received. The body fat percentage (the ratio of fat to the whole body) before and after continuous use was measured by a measuring device (body fat meter BFT-2000, manufactured by Kett Kagaku) based on the principle of light reflection at an outside infrared wavelength. Twenty out of 90 persons were set as a control group from which the avocado extract and caffeine were removed from Example 1, and 20 out of 90 persons were set as a sample from which the avocado extract was removed from Example 1 (Comparative Example 1). The average of the rates was determined. Table 2 shows the results.

[0048]

[Table 2] 前 Before continuous use After continuous use ───────────────── ──────── Control 33.5 ± 5.1% 34.7 ± 5.6% Example 1 34.7 ± 7.2% 27.5 ± 6.5% Comparative Example 1 33.8 ± 6.2% 30.2 ± 4.2% ─────────── ──────────────

As is clear from the above results, the product of the present invention has a remarkable decrease in the body fat percentage as compared with the control group and Comparative Example 1.

Example 1 Cream (1) 3.5% by weight of cetostearyl alcohol (2) Squalane 40.0 (3) Beeswax 3.0 (4) Reduced lanolin 5.0 (5) Ethyl paraben 0.3 (6 ) Polyoxyethylene (20) sorbitan monopalmitate 2.0 (7) monoglyceride stearate 2.0 (8) sodium N-stearoyl glutamate 0.5 (9) 2-hydroxy-4-methoxybenzophenone 1.0 ( 10) Retinol acetate 2.0 (11) Evening primrose oil 0.05 (12) Fragrance 0.05 (13) Avocado extract 6.0 (14) Caffeine 0.1 (15) Green tea extract 3.0 (16) ) Sodium hexametaphosphate 0.02 (17) 1,3-butylene glycol 0.1 (18) Purified water residue

(Preparation method) Avocado extract was prepared by adding 500 ml of 30 V / V% aqueous ethanol solution to 500 g of avocado shreds, extracting at 50 ° C. for 60 minutes, cooling, filtering naturally with filter paper, and adding water to make a total of 500 ml. And (1)-(12)
Is dissolved under heating and added to (13) to (18) heated to 70 ° C. while stirring. After homogenizing the emulsion to make the emulsified particles fine, the mixture was rapidly cooled while stirring to obtain a cream.

Example 2 Lotion (1) Tabunoki extract 1.0% by weight (2) Isoproterenol hydrochloride 0.1 (3) Glycerin 4.0 (4) 1,3-butylene glycol 4.0 ( 5) Tocopherol acetate 0.05 (6) Ethanol 7.0 (7) Polyoxyethylene (18) oleyl alcohol ether 0.5 (8) Methyl paraben 0.2 (9) Citric acid 0.05 (10) Sodium citrate 0.1 (11) Trisodium ethylenediaminetetraacetate 0.02 (12) Fragrance 0.05 (13) Purified water residue

(Preparation method) As for the extract of tabunoki, 500 ml of water was added to 500 g of sliced tabunoki, extracted at 50 ° C. for 60 minutes, cooled, filtered naturally with filter paper, and added with water to a total volume of 50%.
The volume was 0 ml. In purified water, citric acid, sodium citrate, glycerin, 1,3-butylene glycol, tabunoki extract, isoproterenol hydrochloride, and trisodium ethylenediaminetetraacetate are dissolved (aqueous phase). Separately, polyoxyethylene oleyl alcohol ether, tocopherol acetate, perfume, and methyl paraben were dissolved in ethanol, added to the above-mentioned aqueous phase, solubilized, and filtered to obtain a lotion.

Example 3 Emulsion (1) 1.5% by weight of stearic acid (2) Cetyl alcohol 0.5 (3) Beeswax 2.0 (4) Polyoxyethylene (10) monooleate 1.0 (5) ) Octyl methoxycinnamate 2.0 (6) Green oak extract 0.7 (7) Sodium hyaluronate 0.01 (8) Triethanolamine 0.75 (9) Glycerin 7.0 (10) Inosit 0.5 (11) Caffeine 0.2 (12) Sodium ethylenediaminehydroxytriacetate 0.01 (13) Ethylparaben 0.3 (14) Fragrance 0.03 (15) Purified water residue

(Preparation method) A green oak extract was prepared by adding 500 ml of water to 500 g of green oak and extracting at 50 ° C. for 60 minutes. After cooling, the mixture was naturally filtered with a filter paper, and water was added to a total volume of 50 g.
The volume was 0 ml. A blue oak extract, sodium hyaluronate, glycerin, inosit, caffeine, sodium ethylenediaminehydroxytriacetate, and triethanolamine are added to purified water, and the mixture is maintained at 70 ° C (aqueous phase). The other components are mixed, dissolved by heating and kept at 70 ° C. (oil phase). Preliminary emulsification is performed by adding the oil phase to the water phase, and the mixture is uniformly emulsified with a homomixer. Thereafter, the mixture was rapidly cooled while stirring to obtain an emulsion.

Example 4 Foam pack (1) Avocado extract 1.1% by weight (2) Yohimbine hydrochloride 0.02 (3) Sodium metaphosphate 0.02 (4) 1,3-butylene glycol 5.0 ( 5) Glycerin 7.0 (6) Methyl paraben 0.1 (7) Potassium hydroxide 0.15 (8) Stearic acid 0.5 (9) Myristic acid 1.0 (10) Bacyl alcohol 1.5 (11) Poly Oxyethylene (60) hydrogenated castor oil 3.0 (12) Perfume 0.05 (13) Liquefied petroleum gas 6.0 (14) Dimethyl ether 3.0 (15) Purified water residue

(Preparation method) Avocado extract was prepared by adding 500 ml of a 1,3-butylene glycol solution to 500 g of avocado shreds.
And extracted at 50 ° C. for 60 minutes. After cooling, the mixture was naturally filtered through a filter paper, and 1,3-butylene glycol was added to add a total of 5
00 ml. Add (1) to (7) to (15) and heat and dissolve at 70 ° C. Add (8) to (12) with heating and stirring to 75 ° C, stir well, then cool. . This was filled in a container, and finally (13) and (14) were filled as a propellant to obtain a foam pack.

Example 5 Ointment (1) Avocado extract 11.0% by weight (2) Amrinone 0.2 (3) Trimethylglycine 0.2 (4) Sodium ethylenediaminehydroxytriacetate 0.01 (5) Retinol palmitate 0.5 (6) Stearyl alcohol 18.0 (7) Mokuro 20.0 (8) Polyoxyethylene (20) monooleate 0.25 (9) Glycerin monostearate 0.3 (10) Vaseline 40 0.0 (11) Purified water residue

(Preparation method) Avocado extract was prepared by adding 500 ml of water to 500 g of avocado shreds, extracting at 50 ° C. for 60 minutes, cooling, filtering naturally with filter paper, and adding water to obtain a total of 50 parts.
The volume was 0 ml. (11) to (1) to (4) were added and dissolved,
(Aqueous phase). The remaining components (5) to (10) are mixed and dissolved at 70 ° C. (oil phase). The oil phase was added to the aqueous phase, and the mixture was uniformly emulsified with a homomixer and then cooled to obtain an ointment.

Example 6 Emulsion for Massage (1) 1.5% by weight of stearic acid (2) Cetyl alcohol 0.5 (3) Polyoxyethylene (10) monooleate 1.0 (4) Vaseline 3.0 (5) Squalane 10.0 (6) Liquid paraffin 5.0 (7) Glycerin 7.0 (8) 1,3-butylene glycol 5.0 (9) Triethanolamine 0.75 (10) Tabunoki extract 1 0.05 (11) Caffeine 3.0 (12) Theophylline 2.0 (13) Sodium metaphosphate 0.02 (14) Sodium ethylenediaminehydroxytriacetate 0.01 (15) Ethylparaben 0.25 (16) Fragrance 0 .02 (17) Purified water residue

(Preparation method) As for the extract of Tabunoki, 500 ml of water was added to 500 g of the cut pieces of Tabunoki, extracted at 50 ° C. for 60 minutes, cooled, filtered naturally with filter paper, and added with water to a total volume of 50%.
The volume was 0 ml. (7) to (16) are added to (17), and the mixture is maintained at 70 ° C. (aqueous phase). The other components are mixed, dissolved by heating and kept at 70 ° C. (oil phase). Preliminary emulsification is performed by adding the oil phase to the water phase, and the mixture is uniformly emulsified with a homomixer. Thereafter, the mixture was rapidly cooled with stirring to obtain a milky lotion for massage.

Example 7 Massage gel (1) Isoproterenol hydrochloride 2.0% by weight (2) Avocado extract 8.0 (3) Glycerin 50.0 (4) Trimethylglycine 0.2 (5) Carboxy Vinyl polymer 0.4 (6) Polyethylene glycol 400 30.0 (7) Sodium ethylenediamine hydroxytriacetate 0.1 (8) Polyoxyethylene (10) methylpolysiloxane copolymer 2.0 (9) Squalane 1.0 (10) Fragrance 0.12 (11) Potassium hydroxide 0.15 (12) Purified water residue

(Preparation method) Avocado extract was prepared by adding 500 ml of a 20 V / V% methanol aqueous solution to 500 g of avocado shreds, extracting at 50 ° C. for 60 minutes, cooling, filtering naturally with filter paper, and adding water to make a total of 500 ml. And (12) to (1)
Dissolve (7). Separately, a mixture of (8) to (10) was added, and then (11) was added to obtain a massage gel.

Example 8 Serum (1) Aogashi extract 20.0% by weight (2) Tranexamic acid 1.0 (3) Yohimbine hydrochloride 0.1 (4) L-arginine L-aspartate 0.1 (5) Sodium hyaluronate 0.01 (6) Glycerin 10.0 (7) 1,3-butylene glycol 5.0 (8) Carboxyvinyl polymer 0.3 (9) Sodium ethylenediaminehydroxytriacetate 0.01 (10 ) Ethanol 7.0 (11) polyoxyethylene (18) oleyl alcohol ether 0.8 (12) macadamia nut oil 0.1 (13) evening primrose oil 0.01 (14) tocopherol acetate 0.01 (15) methyl paraben 15 (16) Fragrance 0.1 (17) Potassium hydroxide 0.08 (18) Purified water residue

(Preparation method) A green oak extract was prepared by adding 500 ml of water to 500 g of green shredded green oak, extracting at 50 ° C. for 60 minutes, cooling, filtering naturally with a filter paper, and adding water to obtain a total of 50 g.
The volume was 0 ml. Dissolve (1)-(9) in (18) and separately in (10)
A solution obtained by dissolving (11) to (16) is added. Thereafter, (17) was added to obtain a serum.

[0066]

As described above, the lipolysis promoting agent of the present invention has a high action of promoting lipolysis of adipocytes, and has an excellent slimming effect.

Claims (7)

[Claims] 1. An agent for promoting lipid degradation, comprising an extract of a plant belonging to the family Camphor tree (Perseae). 2. The lipolysis promoter according to claim 1, wherein the extract of the plant belonging to the family Leucaena (Perseae) is an avocado extract. 3. A mixture of an extract of a plant belonging to the family Camphor tree (Perseae) with one or more selected from a xanthine derivative, a β-adrenergic stimulant, an α2-adrenergic inhibitor and a bipyridine derivative. A skin external preparation for slimming, characterized in that: 4. The skin external preparation for slimming according to claim 3, wherein the xanthine derivative is selected from the group consisting of caffeine, aminophylline, theophylline and pharmaceutically acceptable salts thereof. 5. The external preparation for slimming skin according to claim 3, wherein the β-adrenergic stimulant is selected from the group consisting of isoproterenol, dobudamine, salbutamol and pharmaceutically acceptable salts thereof. 6. The external preparation for slimming skin according to claim 3, wherein the α2 adrenergic action inhibitor is selected from the group consisting of yohimbine, phentolamine, ergotamine and pharmacologically acceptable salts thereof. 7. The external preparation for slimming skin according to claim 3, wherein the bipyridine derivative is selected from the group consisting of amrinone, milrinone and a pharmaceutically acceptable salt thereof.