JP2017165686A - Liver function improver - Google Patents
Liver function improver Download PDFInfo
- Publication number
- JP2017165686A JP2017165686A JP2016052940A JP2016052940A JP2017165686A JP 2017165686 A JP2017165686 A JP 2017165686A JP 2016052940 A JP2016052940 A JP 2016052940A JP 2016052940 A JP2016052940 A JP 2016052940A JP 2017165686 A JP2017165686 A JP 2017165686A
- Authority
- JP
- Japan
- Prior art keywords
- liver function
- mass
- parts
- improving agent
- vitamin
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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Landscapes
- Coloring Foods And Improving Nutritive Qualities (AREA)
- Medicinal Preparation (AREA)
- Cosmetics (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Medicines Containing Plant Substances (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
Description
本発明は、肝機能改善剤に係り、詳しくは、テクトリゲニン類及び特定の他成分を含有することを特徴とする肝機能改善剤に関する。 The present invention relates to a liver function improving agent, and more particularly, to a liver function improving agent characterized by containing tectorigenin and a specific other component.
テクトリゲニン類はアヤメ科やマメ科の植物に存在するフラボノイドの一つであり、サーチュインを活性化すること（特許文献１参照）、Ｂｍａｌ１遺伝子の発現を活性化すること等が知られている（特許文献２参照）。
テクトリゲニン類は植物に含まれていることから、安全性が比較的高く日常的に摂取しやすいと考えられるが、その活性や機能については未だ不明な点も多い。
Tectrigenins are one of the flavonoids present in Iridaceae and leguminous plants, and are known to activate sirtuins (see Patent Document 1), activate Bmal1 gene expression, etc. (patents) Reference 2).
Tectrigenins are contained in plants and are considered to be relatively safe and easy to take on a daily basis, but there are still many unclear points about their activity and function.
そこで、本発明においては、テクトリゲニン類と特定の他成分とを組み合わせて、従来にない優れた肝機能改善剤を得ることを目的に種々の検討を行った。 Therefore, in the present invention, various studies have been conducted for the purpose of obtaining an unprecedented excellent liver function improving agent by combining tectorigenins and specific other components.
本発明者らは、テクトリゲニン類と多種多様な成分とを組み合わせて肝機能改善作用を試験したところ、テクトリゲニン類と特定の他成分とを組み合わせることにより、肝機能改善作用が飛躍的に向上することを見い出した。 The inventors of the present invention tested liver function improving action by combining tectorigenins and a wide variety of components. By combining tectorigenins and specific other components, the liver function improving action is dramatically improved. I found out.
本発明は具体的には、
テクトリゲニン類と、下記（ａ）〜（ｆ）からなる群より選ばれる少なくとも１種の成分とを含有することを特徴とする肝機能改善剤である。
（ａ）ビタミンＢ２、パントテン酸ナトリウム、ビオチン、ビタミンＥから選ばれる少なくとも１種のビタミン類
（ｂ）ヨモギ、黒ショウガ（Ｋａｅｍｐｆｅｒｉａ ｐａｒｖｉｆｌｏｒａ）、米ぬか、米胚芽から選ばれる少なくとも１種の植物素材
（ｃ）穀物麹、黒酢、小麦ふすま発酵エキス末、もろみ酢、ビール酵母から選ばれる少なくとも１種の発酵関連素材
（ｄ）アラニン、イソロイシン、リジン、プロリン、チロシンから選ばれる少なくとも１種のアミノ酸（塩を含む）
（ｅ）鉄、モリブデン、亜鉛、チタン、没食子酸、クロロゲン酸、クルクミン、カフェイン、Ｌ−カルニチン、α‐リポ酸から選ばれる少なくとも１種の機能性添加剤
（ｆ）アスパルテーム、麦芽糖、フラクトオリゴ糖から選ばれる少なくとも１種の甘味料
The present invention specifically includes:
It is a liver function improving agent characterized by containing tectorigenins and at least one component selected from the group consisting of the following (a) to (f).
(A) At least one vitamin selected from vitamin B2, sodium pantothenate, biotin, and vitamin E (b) At least one plant material selected from mugwort, black ginger (Kaempferia parviflora), rice bran, and rice germ (c ) At least one fermentation-related material selected from cereal meal, black vinegar, wheat bran fermentation extract powder, moromi vinegar, brewer's yeast (d) at least one amino acid (salt) selected from alanine, isoleucine, lysine, proline, tyrosine including)
(E) At least one functional additive selected from iron, molybdenum, zinc, titanium, gallic acid, chlorogenic acid, curcumin, caffeine, L-carnitine, α-lipoic acid (f) aspartame, maltose, fructooligosaccharide At least one sweetener selected from
また、本発明は、テクトリゲニン類と（ａ）〜（ｆ）からなる群より選ばれる少なくとも１種の成分とからなる成分を添加して得たことを特徴とする肝機能改善剤であることが好ましい。 Further, the present invention is a liver function improving agent obtained by adding a component consisting of tectrigenins and at least one component selected from the group consisting of (a) to (f). preferable.
また、本発明は、錠剤、カプセル剤、粉末剤、顆粒剤、又は液剤であることを特徴とする肝機能改善剤であることが好ましい。 In addition, the present invention is preferably a liver function improving agent characterized by being a tablet, capsule, powder, granule, or liquid.
本発明によれば、優れた肝機能改善作用を有する肝機能改善剤を提供することができる。 ADVANTAGE OF THE INVENTION According to this invention, the liver function improving agent which has the outstanding liver function improvement effect can be provided.
本発明の肝機能改善剤としては、テクトリゲニン類及び特定の他成分を含有するものであれば特に制限されるものではない。また、本発明の肝機能改善剤は優れた肝機能改善作用を有し、肝機能の亢進又は肝障害の抑制が期待できる。特に、本発明のテクトリゲニン類と特定の他成分との組み合わせは、肝細胞の傷害を防ぐ。これにより、肝細胞中のアスパラギン酸アミノトランスフェラーゼ（ＡＳＴ）、アラニンアミノ基転移酵素（Ａｌａｎｉｎｅ ｔｒａｎｓａｍｉｎａｓｅ、ＡＬＴ）、γ−グルタミルトランスペプチダーゼ（γ−Ｇｌｕｔａｍｙｌｔｒａｎｓｆｅｒａｓｅ、γ−ＧＴＰ）の血中への逸脱が抑制されることが期待される。 The liver function improving agent of the present invention is not particularly limited as long as it contains tectorigenins and specific other components. Moreover, the liver function improving agent of the present invention has an excellent liver function improving action, and can be expected to enhance liver function or suppress liver damage. In particular, the combination of the tectorigenins of the present invention with certain other components prevents damage to hepatocytes. As a result, the aspartate aminotransferase (AST), alanine aminotransferase (ALT), and γ-glutamyltranspeptidase (γ-Glutamyltransferase, γ-GTP) in the liver cells are suppressed. It is expected that
本発明に用いられるテクトリゲニン類とは、テクトリゲニン、その配糖体又は誘導体、及びそれらの混合物を意味する。テクトリゲニン類は通常知られているテクトリゲニン類であれば特に限定されないが、テクトリゲニン（ｔｅｃｔｏｒｉｇｅｎｉｎ）、テクトリジン（ｔｅｃｔｏｒｉｄｉｎ）及びテクトリゲニン７−Ｏ−キシロシルグルコシド（ｔｅｃｔｏｒｉｇｅｎｉｎ ７−Ｏ−ｘｙｌｏｓｙｌｇｌｕｃｏｓｉｄｅ（ＴＧＸＧ）が好ましく、これらの混合物が特に好ましい。 Tectorigenin used in the present invention means tectorigenin, its glycoside or derivative, and a mixture thereof. The tectorigenins are not particularly limited as long as they are generally known tectorigenins, but tectorigenin, tectoridine, and tectorigenin 7-O-xylosylglucoside (TGXG) are preferable. The mixture of is particularly preferred.
本発明に用いられるテクトリゲニン類は、合成されたものであっても植物に含まれるものであっても良いが、安全性等の観点から植物から抽出されたものが好ましく、アヤメ科やマメ科の植物から抽出したものが特に好ましい。アヤメ科植物やマメ科の植物としては、ハナショウブ、アヤメ、クズ、カキツバタ等が知られている。 The tectorigenins used in the present invention may be synthesized or contained in plants, but those extracted from plants are preferable from the viewpoint of safety and the like, and Iridaceae and legumes Those extracted from plants are particularly preferred. As the Iridaceae plant and the Leguminosae plant, hanashoubu, iris, kuzu, oyster butterfly and the like are known.
テクトリゲニン類を植物から抽出する場合、植物の幹、枝、果実、葉、花、種子、樹皮、樹液、根、茎、芽等のいずれの部位を用いても構わないが、簡便に利用するには、葉や花を用いるとよい。抽出の際は、生のまま用いてもよいが、抽出効率を考えると、細切、乾燥、粉砕等の処理を行った後に抽出を行うことが好ましい。抽出は、抽出溶媒に浸漬するか、抽出効率を上げるため、撹拌や抽出溶媒中でホモジナイズしてもよい。抽出温度としては、５℃程度から抽出溶媒の沸点以下の温度とするのが適切である。抽出時間は抽出溶媒の種類や抽出温度によっても異なるが、１時間〜３０日間程度とするのが適切である。 When extracting tectorigenins from plants, any part of plant trunks, branches, fruits, leaves, flowers, seeds, bark, sap, roots, stems, buds, etc. may be used. Use leaves and flowers. In the extraction, it may be used as it is, but considering the extraction efficiency, it is preferable to perform the extraction after performing processing such as shredding, drying, and pulverization. The extraction may be immersed in an extraction solvent or homogenized in stirring or extraction solvent to increase extraction efficiency. The extraction temperature is suitably about 5 ° C. to the boiling point of the extraction solvent. The extraction time varies depending on the type of extraction solvent and the extraction temperature, but it is appropriate to set it to about 1 hour to 30 days.
抽出溶媒としては、水の他、生理食塩水、リン酸緩衝液、リン酸緩衝生理食塩水等を用いてもよい。また、メタノール、エタノール、プロパノール、イソプロパノール等の低級アルコール、１、３−ブチレングリコール、プロピレングリコール、ジプロピレングリコール、グリセリン等の多価アルコール、エチルエーテル、プロピルエーテル等のエーテル類、酢酸エチル、酢酸ブチル等のエステル類、アセトン、エチルメチルケトン等のケトン類等の極性有機溶媒を用いることができ、これらより１種又は２種以上を選択して用いることができる。 As the extraction solvent, in addition to water, physiological saline, phosphate buffer, phosphate buffered saline, or the like may be used. Also, lower alcohols such as methanol, ethanol, propanol and isopropanol, polyhydric alcohols such as 1,3-butylene glycol, propylene glycol, dipropylene glycol and glycerin, ethers such as ethyl ether and propyl ether, ethyl acetate and butyl acetate Polar organic solvents such as esters such as acetone and ketones such as ethyl methyl ketone can be used, and one or more of these can be selected and used.
アヤメ科やマメ科の上記溶媒による抽出物に含まれるテクトリゲニン類は、そのままでも使用することができるが、濃縮、乾固した物を水や極性溶媒に再度溶解したり、或いはこれらの生理作用を損なわない範囲で脱色、脱臭、脱塩等の精製処理を行ったり、カラムクロマトグラフィー等による分画処理を行った後に用いてもよい。 Tectigenin contained in extracts of the above-mentioned solvents of Iridaceae and legumes can be used as they are, but the concentrated and dried solids can be dissolved again in water or a polar solvent, or their physiological action can be improved. It may be used after performing purification treatment such as decolorization, deodorization, desalting, etc. within a range that does not impair, or after performing fractionation treatment by column chromatography or the like.
本発明で用いるテクトリゲニン類の入手方法は上記の通り植物から抽出することもできるが、当業者に通常知られる方法により合成された合成物、市販品、該市販品を化学処理、酵素処理、精製処理等に供することによって得られた処理物等を用いてもよい。例えば、テクトリゲニン及びテクトリジンは関東化学社から得ることができる。 The method for obtaining tectorigenins used in the present invention can be extracted from plants as described above, but synthetic products synthesized by methods generally known to those skilled in the art, commercially available products, chemical treatments, enzyme treatments, and purification of the commercially available products. You may use the processed material etc. which were obtained by using for a process etc. For example, tectorigenin and tectoridine can be obtained from Kanto Chemical.
テクトリゲニン類の含有量は特に限定されず、例えば、本発明の肝機能改善剤の全量に対して、０．０１質量％以上、好ましくは０．０５〜２０質量％、より好ましくは０．１〜１０質量％、特に好ましくは０．５〜５質量％である。この場合のテクトリゲニン類の含有量とは、テクトリゲニン、テクトリジン及びＴＧＸＧの含有量の総量をいう。 The content of tectorigenins is not particularly limited, and for example, 0.01% by mass or more, preferably 0.05 to 20% by mass, more preferably 0.1 to 0.1% by mass with respect to the total amount of the liver function improving agent of the present invention. It is 10 mass%, Most preferably, it is 0.5-5 mass%. The content of tectorigenins in this case refers to the total content of tectorigenin, tectoridine and TGXG.
［他成分］
本発明の肝機能改善剤は、テクトリゲニン類と特定の他成分とを含有することを特徴とし、特定の他成分としては、肝機能改善能がほとんどないか、その能力が小さい他成分を、テクトリゲニン類と組み合わせることにより、肝機能改善能を相乗的に向上させることができる成分であれば限定されないが、特に以下に記載する（ａ）〜（ｆ）からなる群より選ばれる少なくとも１種の成分とを含有することが望ましい。
[Other ingredients]
The liver function-improving agent of the present invention is characterized by containing tectrigenin and a specific other component. As the specific other component, other component with little or no ability to improve liver function is used as tectrigenin. Although it will not be limited if it is a component which can improve liver function improvement ability synergistically by combining with a kind, Especially at least 1 sort (s) of components chosen from the group which consists of (a)-(f) described below It is desirable to contain.
（ａ）ビタミン類
本発明の肝機能改善剤においては、テクトリゲニン類と共に、他成分として、ビタミンＢ２、パントテン酸ナトリウム、ビオチン、ビタミンＥから選ばれる少なくとも１種のビタミン類を用いることが好ましい。これらのビタミン類は、特に限定されないが、化粧品や飲食品の原料として利用される市販のものを用いることができる。これらの他成分は、テクトリゲニン類と組み合わせた場合に、相乗的な肝機能改善作用が得られるだけでなく、テクトリゲニン類の呈味を改善することができる。さらに、テクトリゲニン類と組み合わせて飲料、錠剤とした際にテクトリゲニン類の体内への吸収性を高めることができる。
(A) Vitamins In the liver function-improving agent of the present invention, it is preferable to use at least one vitamin selected from vitamin B2, sodium pantothenate, biotin, and vitamin E as other components together with tectrigenins. Although these vitamins are not specifically limited, the commercially available thing utilized as a raw material of cosmetics and food-drinks can be used. When these other components are combined with tectorigenins, not only a synergistic liver function improving action can be obtained, but also the taste of tectorigenins can be improved. Furthermore, when it is used as a beverage or a tablet in combination with tectorigenins, the absorbability of tectorigenins into the body can be increased.
（ｂ）植物素材
本発明の肝機能改善剤においては、テクトリゲニン類と共に、他成分として、ヨモギ（Ａｒｔｅｍｉｓｉａ ｉｎｄｉｃａ）、黒ショウガ（Ｋａｅｍｐｆｅｒｉａ ｐａｒｖｉｆｌｏｒａ）、米ぬか、米胚芽から選ばれる少なくとも１種の植物素材を用いることが好ましい。これらの他成分は、テクトリゲニン類と組み合わせた場合に、相乗的な肝機能改善作用が得られるだけでなく、テクトリゲニン類の呈味を改善することができる。さらに、水にテクトリゲニン類のみを溶解した場合よりも、色味に優れ、また分散性に優れたものとすることができる。
(B) Plant material The liver function-improving agent of the present invention comprises at least one plant material selected from Artemisia indica, black ginger (Kaempferia parviflora), rice bran, and rice germ, together with tectreggenins. It is preferable to use it. When these other components are combined with tectorigenins, not only a synergistic liver function improving action can be obtained, but also the taste of tectorigenins can be improved. Furthermore, it can be excellent in color and dispersibility compared with the case where only tectrigenins are dissolved in water.
これらの植物素材の中で、ヨモギと黒ショウガについては、花、葉、茎、根等、植物のいずれの部位であってもよいが、通常食用される部位が好ましく、植物素材そのもの（乾燥物を含む）、その粉砕物、搾汁、抽出物等を用いることができる。粉砕物としては、粉末、顆粒等が挙げられる。搾汁や抽出物は、液状であってもよいが、ペースト状や乾燥粉末として用いることもできる。抽出物は、適当な溶媒を用いて抽出することによって得ることができ、溶媒としては、例えば、水、エタノール、含水エタノールを用いることができる。 Among these plant materials, mugwort and black ginger may be any part of the plant, such as flowers, leaves, stems, roots, etc., but usually edible parts are preferred, and the plant material itself (dry matter) ), Pulverized products, juices, extracts, and the like. Examples of the pulverized product include powder and granules. The squeezed juice or extract may be liquid, but can also be used as a paste or dry powder. The extract can be obtained by extraction using an appropriate solvent. As the solvent, for example, water, ethanol, or hydrous ethanol can be used.
米ぬかは、米を精米した際に出る果皮、種皮、胚芽等を分離したものである。米ぬかとしては、特に限定されないが、化粧品や飲食品の原料として利用される市販のものを用いることができる。 Rice bran is obtained by separating the pericarp, seed coat, germ, etc. produced when rice is polished. Although it does not specifically limit as rice bran, The commercially available thing utilized as a raw material of cosmetics and food-drinks can be used.
米胚芽には、米の胚芽や胚芽に含まれる成分を単離したものが挙げられる。米胚芽としては、特に限定されないが、化粧品や飲食品の原料として利用される市販のものを用いることができる。 Rice germs include those obtained by isolating rice germ and components contained in the germ. Although it does not specifically limit as a rice germ, The commercially available thing utilized as a raw material of cosmetics and food-drinks can be used.
（ｃ）発酵関連素材
本発明の肝機能改善剤においては、テクトリゲニン類と共に、他成分として、穀物麹、黒酢、小麦ふすま発酵エキス末、もろみ酢、ビール酵母から選ばれる少なくとも１種の発酵関連素材を用いることが好ましい。これらの他成分は、テクトリゲニン類と組み合わせた場合に、相乗的な肝機能改善作用が得られるだけでなく、テクトリゲニン類の呈味を改善することができる。さらに、水にテクトリゲニン類のみを溶解した場合よりも、色味に優れ、また分散性に優れたものとすることができる。
(C) Fermentation-related material In the liver function improving agent of the present invention, at least one kind of fermentation-related selected from cereal meal, black vinegar, wheat bran fermented extract powder, moromi vinegar, and brewer's yeast as tetrigenins. It is preferable to use a material. When these other components are combined with tectorigenins, not only a synergistic liver function improving action can be obtained, but also the taste of tectorigenins can be improved. Furthermore, it can be excellent in color and dispersibility compared with the case where only tectrigenins are dissolved in water.
これら発酵関連素材は、特に限定されないが、発酵関連素材をそのまま用いても良く、発酵関連素材を乾燥させて、粉砕したものを用いても良い。また、発酵関連素材から抽出したものであっても良く、抽出物をそのまま、或いは粉砕して用いることができる。粉砕物としては、粉末、顆粒等が挙げられる。抽出物は、液状であってもよいが、ペースト状や乾燥粉末として用いることもできる。抽出物は、適当な溶媒を用いて抽出することによって得ることができ、溶媒としては、例えば、水、エタノール、含水エタノールを用いることができる。 These fermentation-related materials are not particularly limited, but the fermentation-related materials may be used as they are, or the fermentation-related materials may be dried and pulverized. Moreover, what was extracted from the fermentation related raw material may be used, and an extract can be used as it is or grind | pulverized. Examples of the pulverized product include powder and granules. The extract may be liquid, but can also be used as a paste or a dry powder. The extract can be obtained by extraction using an appropriate solvent. As the solvent, for example, water, ethanol, or hydrous ethanol can be used.
穀物麹は、大麦、アワ、ヒエ、キビ、タカキビ、紫黒米及び米粉の７つを麹菌を用いて発酵させたものであり、黒酢、小麦ふすま発酵エキス末、もろみ酢、ビール酵母は、特に限定されないが、化粧品や飲食品の原料として利用される市販のものを用いることができる。 Cereal meal is made by fermenting 7 kinds of barley, millet, millet, millet, purple millet, purple black rice and rice flour using koji mold. Black vinegar, wheat bran fermentation extract powder, moromi vinegar, brewer's yeast Although not limited, the commercially available thing utilized as a raw material of cosmetics and food-drinks can be used.
穀物麹、黒酢、小麦ふすま発酵エキス末、もろみ酢の発酵に使用する麹は、特に限定されないが、米、麦、大豆、アワ、ヒエ、キビ等の穀物を麹菌で発酵させたものであれば良く、発酵に用いる麹菌としては、黄麹菌、青麹菌、白麹菌、黒麹菌、紅麹等のいずれを用いても良い。具体的には、アスペルギルス・アワモリ（Ａｓｐｅｒｇｉｌｌｕｓ ａｗａｍｏｒｉ）（黒麹菌）、アスペルギルス・サイトイ（Ａｓｐｅｒｇｉｌｌｕｓ ｓａｉｔｏｉ）（黒麹菌）、アスペルギルス・ナカザワイ（Ａｓｐｅｒｇｉｌｌｕｓ ｎａｋａｚａｗａｉ）(黒麹菌)、アスペルギルス・ウサミ（Ａｓｐｅｒｇｉｌｌｕｓ ｕｓａｍｉｉ）（黒麹菌）、アスペルギルス・ルーチェンシス（Ａｓｐｅｒｇｉｌｌｕｓ ｌｕｃｈｅｎｓｉｓ）（黒麹菌）、アスペルギルス・ニガー（Ａｓｐｅｒｇｉｌｌｕｓ ｎｉｇｅｒ）（黒麹菌）、アスペルギルス・カワチ（Ａｓｐｅｒｇｉｌｌｕｓ ｋａｗａｃｈｉｉ）（白麹菌）、アスペルギルス・オリゼー（Ａｓｐｅｒｇｉｌｌｕｓ ｏｒｙｚａｅ）（黄麹菌）等のアスペルギルス属に属する微生物を挙げることができる。 Grain koji, black vinegar, wheat bran fermented extract powder, koji used for fermentation of moromi vinegar are not particularly limited, but may be rice, wheat, soybean, millet, millet, millet, etc. fermented with koji mold As the koji mold used for fermentation, any of koji mold, blue koji mold, white koji mold, black koji mold, red koji mold, etc. may be used. Specifically, Aspergillus awamori (Aspergillus sawai), Aspergillus nakaisai (Aspergillus nakasai) (Aspergillus nakasai) Aspergillus lucensis (Aspergillus luciferis), Aspergillus kawachii (Aspergillus spp. Such as microorganisms belonging to the genus Aspergillus Rukoto can.
（ｄ）アミノ酸
本発明の肝機能改善剤においては、テクトリゲニン類と共に、他成分として、アラニン、イソロイシン、リジン、プロリン、チロシンから選ばれる少なくとも１種のアミノ酸を用いることが好ましい。塩としては、例えば、ナトリウム塩、塩酸塩等を挙げることができる。これらのアミノ酸類は、特に限定されないが、化粧品や飲食品の原料として利用される市販のものを用いることができる。これらの他成分は、テクトリゲニン類と組み合わせた場合に、相乗的な肝機能改善作用が得られるだけでなく、テクトリゲニン類の呈味を改善することができる。さらに、水にテクトリゲニン類のみを溶解した場合よりも、色味に優れ、また分散性に優れたものとすることができる。
(D) Amino acid In the liver function improving agent of the present invention, it is preferable to use at least one amino acid selected from alanine, isoleucine, lysine, proline, and tyrosine as the other component together with tectrigenins. Examples of the salt include sodium salt and hydrochloride. These amino acids are not particularly limited, and commercially available products used as raw materials for cosmetics and foods and drinks can be used. When these other components are combined with tectorigenins, not only a synergistic liver function improving action can be obtained, but also the taste of tectorigenins can be improved. Furthermore, it can be excellent in color and dispersibility compared with the case where only tectrigenins are dissolved in water.
（ｅ）機能性添加剤
本発明の肝機能改善剤においては、テクトリゲニン類と共に、他成分として、鉄、モリブデン、亜鉛、チタン、没食子酸、クロロゲン酸、クルクミン、カフェイン、Ｌ−カルニチン、α‐リポ酸から選ばれる少なくとも１種の機能性添加剤を用いることが好ましい。これらの機能性添加剤は、特に限定されないが、化粧品や飲食品の原料として利用される市販のものを用いることができる。これらの他成分は、テクトリゲニン類と組み合わせた場合に、相乗的な肝機能改善作用が得られるだけでなく、テクトリゲニン類の呈味を改善することができる。さらに、水にテクトリゲニン類のみを溶解した場合よりも、色味に優れ、また分散性に優れたものとすることができる。
(E) Functional additive In the liver function-improving agent of the present invention, iron, molybdenum, zinc, titanium, gallic acid, chlorogenic acid, curcumin, caffeine, L-carnitine, α-, as other components together with tectrigenins. It is preferable to use at least one functional additive selected from lipoic acid. These functional additives are not particularly limited, and commercially available products used as raw materials for cosmetics and foods and drinks can be used. When these other components are combined with tectorigenins, not only a synergistic liver function improving action can be obtained, but also the taste of tectorigenins can be improved. Furthermore, it can be excellent in color and dispersibility compared with the case where only tectrigenins are dissolved in water.
（ｆ）甘味料
本発明の肝機能改善剤においては、テクトリゲニン類と共に、他成分として、アスパルテーム、麦芽糖、フラクトオリゴ糖から選ばれる少なくとも１種の甘味料を用いることが好ましい。これらの甘味料は、特に限定されないが、化粧品や飲食品の原料として利用される市販のものを用いることができる。これらの他成分は、テクトリゲニン類と組み合わせた場合に、相乗的な肝機能改善作用が得られるだけでなく、テクトリゲニン類の呈味を改善することができる。さらに、水にテクトリゲニン類のみを溶解した場合よりも、色味に優れ、また分散性に優れたものとすることができる。
(F) Sweetener In the liver function improving agent of the present invention, it is preferable to use at least one sweetener selected from aspartame, maltose, and fructooligosaccharide as the other component together with the tectorigenins. Although these sweeteners are not specifically limited, The commercially available thing utilized as a raw material of cosmetics and food-drinks can be used. When these other components are combined with tectorigenins, not only a synergistic liver function improving action can be obtained, but also the taste of tectorigenins can be improved. Furthermore, it can be excellent in color and dispersibility compared with the case where only tectrigenins are dissolved in water.
[使用の形態]
本発明の肝機能改善剤は、肝機能改善の用途に用いられる点において、製品として他の製品と区別できるものであればよく、例えば、本発明の肝機能改善剤に係る製品の本体、包装、説明書、宣伝物のいずれかに肝機能改善の機能がある旨を表示したものを挙げることができる。肝機能改善機能がある旨の表示とは、例えば、肝臓の健康を維持したい方、肝臓の健康を維持する、肝臓の働きをサポートする、肝臓の健康に、肝臓機能の改善に、といったように肝臓の健康の維持増進に役立つことの表示や、肝機能が気になる方、肝臓の健康が気になる方、お酒をよく飲む方、といったように肝臓の働きを気にする対象者に訴えかける表示をいう。
[Type of use]
The liver function-improving agent of the present invention may be any product that can be distinguished from other products as a product in terms of being used for the purpose of improving liver function. For example, the main body and packaging of the product according to the liver function-improving agent of the present invention , Any of the instructions and advertisements that indicate that there is a function of improving liver function. The indication that there is a liver function improving function is, for example, those who want to maintain liver health, maintain liver health, support liver function, liver health, improve liver function, etc. For those who are concerned about liver function such as indications that help maintain and improve liver health, those who are concerned about liver function, those who are concerned about liver health, those who drink alcohol well, etc. An appealing display.
本発明の肝機能改善剤の利用形態としては、具体的には、医薬品（医薬部外品を含む）、化粧品、一般食品、栄養機能食品の他、消費者庁により効能の表示が認められた特定保健用食品、機能性表示食品等のいわゆる健康食品を挙げることができる。 Specifically, the indication of efficacy is recognized by the Consumer Affairs Agency in addition to pharmaceuticals (including quasi-drugs), cosmetics, general foods, and nutritional functional foods as usage forms of the liver function improving agent of the present invention. Examples include so-called health foods such as foods for specified health use and foods with functional indications.
本発明の肝機能改善剤は、外用又は経口用として使用することができる。外用剤としては、皮膚、頭皮等に塗布して用いるものであれば、特に制限はなく、その形態としては、軟膏剤、クリーム剤、ジェル剤、ローション剤、乳液剤、パック剤、湿布剤等の皮膚外用剤や、注射剤等の形態を挙げることができる。 The liver function improving agent of the present invention can be used for external use or oral use. The external preparation is not particularly limited as long as it is applied to the skin, scalp and the like, and the form is an ointment, cream, gel, lotion, emulsion, pack, poultice, etc. The form of skin external preparations, injections, etc. can be mentioned.
また、本発明の肝機能改善剤を経口剤として用いる場合、その形態としては、例えば、錠剤、カプセル剤、粉末剤、顆粒剤、液剤、粒状剤、棒状剤、板状剤、ブロック状剤、固形状剤、丸状剤、ペースト状剤、クリーム状剤、カプレット状剤、ゲル状剤、チュアブル状剤、スティック状剤等を挙げることができる。これらの中でも、錠剤、カプセル剤、粉末剤、顆粒剤、液剤の形態が、摂取がしやすく肝機能改善作用を得やすいことから特に好ましい。具体的には、サプリメント、食品添加剤、ペットボトル、缶、瓶等に充填された容器詰飲料、水（湯）、牛乳、果汁等に溶解して飲むためのインスタント粉末（顆粒）飲料等を例示することができる。これらは食事の際等に手軽に飲食しやすく、また嗜好性を高めることができるという点で好ましい。 In addition, when the liver function improving agent of the present invention is used as an oral preparation, examples of the form thereof include tablets, capsules, powders, granules, liquids, granules, rods, plates, blocks, Examples thereof include a solid agent, a round agent, a paste agent, a cream agent, a caplet agent, a gel agent, a chewable agent, and a stick agent. Among these, the forms of tablets, capsules, powders, granules, and liquids are particularly preferable because they are easy to ingest and easily obtain liver function improving action. Specifically, supplements, food additives, bottled beverages filled in plastic bottles, cans, bottles, instant powder (granule) beverages for dissolving in water (hot water), milk, fruit juice, etc. It can be illustrated. These are preferable in that they are easy to eat and drink at the time of eating and the like, and can enhance palatability.
本発明の肝機能改善剤におけるテクトリゲニン類及び他成分の含有量としては、その効果の奏する範囲で適宜含有させればよい。本発明の肝機能改善剤は、テクトリゲニン類を有効成分とするものであってもよく、テクトリゲニン類と他成分とを有効成分とするものであってもよい。 The contents of tectorigenins and other components in the liver function improving agent of the present invention may be appropriately contained within the range where the effects are exerted. The liver function-improving agent of the present invention may contain tectrigenins as active ingredients, or tectrigenins and other ingredients as active ingredients.
一般的には、本発明の肝機能改善剤が医薬品やサプリメント（錠剤、カプセル剤）の場合には、テクトリゲニン類及び他成分が乾燥質量換算で全体の０．０１〜１００質量％含まれていることが好ましく、０．１〜８５質量％含まれていることがより好ましく、０．５〜７０質量％含まれていることがさらに好ましい。 In general, when the liver function-improving agent of the present invention is a pharmaceutical product or a supplement (tablet, capsule), tektrigenins and other components are contained in an amount of 0.01 to 100% by mass in terms of dry mass. It is preferable that 0.1 to 85% by mass is included, and 0.5 to 70% by mass is further preferable.
本発明の肝機能改善剤が容器詰飲料（液剤）である場合には、テクトリゲニン類及び他成分が乾燥質量換算で全体の０．０００１〜１０質量％含まれていることが好ましく、０．０００３〜６質量％含まれていることがより好ましく、０．０００５〜４質量％含まれていることがさらに好ましい。 When the liver function improving agent of the present invention is a container-packed beverage (liquid), it is preferable that tectrigenins and other components are contained in an amount of 0.0001 to 10% by mass in terms of dry mass. More preferably, it is contained in an amount of ˜6% by mass, and further preferably contained in an amount of 0.0005-4% by mass.
また、本発明の肝機能改善剤がインスタント粉末飲料（粉末剤）、インスタント顆粒飲料（顆粒剤）である場合には、テクトリゲニン類及び他成分が乾燥質量換算で全体の０．００１〜５０質量％含まれていることが好ましく、０．０１〜４０質量％含まれていることがより好ましく、０．１〜３０質量％含まれていることがさらに好ましい。 Moreover, when the liver function improving agent of the present invention is an instant powder beverage (powder) or an instant granule beverage (granule), the tectorigenins and other components are 0.001 to 50% by mass in terms of dry mass. It is preferably contained, more preferably 0.01 to 40% by mass, and even more preferably 0.1 to 30% by mass.
本発明の効果をより有効に発揮させるためには、テクトリゲニン類及び他成分が乾燥質量換算で本発明の肝機能改善剤全体（水分を除く）の８０質量％以上含まれていることが好ましく、９０質量％以上含まれていることがより好ましく、９５質量％以上含まれていることがさらに好ましく、１００質量％であることが特に好ましい。さらに、本発明の肝機能改善剤が成分（ａ）〜（ｆ）のいずれかを含有する場合、その含有される成分は、本発明に記載される他成分のみで構成されることが好ましい。すなわち、本発明の肝機能改善剤が例えば成分（ａ）植物素材を含有する場合には、それ以外の飲料用植物素材を含まないように構成することが好ましい。 In order to exhibit the effect of the present invention more effectively, it is preferable that tectrigenins and other components are contained in an amount of 80% by mass or more of the whole liver function improving agent of the present invention (excluding moisture) in terms of dry mass, It is more preferably 90% by mass or more, further preferably 95% by mass or more, and particularly preferably 100% by mass. Furthermore, when the liver function improving agent of this invention contains any of component (a)-(f), it is preferable that the component contained is comprised only with the other component described in this invention. That is, when the liver function improving agent of this invention contains a component (a) plant material, for example, it is preferable to comprise so that the plant material for drinks other than that may not be included.
本発明の肝機能改善剤の摂取量としては特に制限はないが、本発明の効果をより顕著に発揮させる観点から、１日当たりのテクトリゲニン類及び他成分の摂取量が、５ｍｇ／日以上となるように摂取することが好ましく、１０ｍｇ／日以上となるように摂取することがより好ましく、２０ｍｇ／日以上となるように摂取することがさらに好ましい。その上限は特に制限されないが、例えば、２ｇ／日であり、好ましくは１ｇ／日である。本発明の肝機能改善剤は、1日の摂取量が前記摂取量となるように、１つの容器に、又は例えば２〜３の複数の容器に分けて、1日分として収容することができる。 Although there is no restriction | limiting in particular as an intake of the liver function improving agent of this invention, From a viewpoint of exhibiting the effect of this invention more notably, the intake of tectrigenin and other components per day will be 5 mg / day or more. Ingestion is preferable, more preferably 10 mg / day or more, and even more preferably 20 mg / day or more. Although the upper limit in particular is not restrict | limited, For example, it is 2 g / day, Preferably it is 1 g / day. The liver function-improving agent of the present invention can be accommodated in one container or divided into a plurality of containers such as 2 to 3 so that the daily intake becomes the above-mentioned intake. .
テクトリゲニン類及び他成分の配合質量比としては、乾燥質量換算で、０．０００１：１〜６０：１の範囲であることが好ましく、０．０００５：１〜５０：１の範囲であることがより好ましく、０．００１：１〜４０：１の範囲であることがさらに好ましく、０．００３：１〜３０：１の範囲であることが特に好ましい。テクトリゲニン類及び他成分の配合比が、上記範囲であることにより、本発明の効果をより有効に発揮することができる。 The blending mass ratio of tectorigenins and other components is preferably in the range of 0.0001: 1 to 60: 1, more preferably in the range of 0.0005: 1 to 50: 1 in terms of dry mass. The range of 0.001: 1 to 40: 1 is more preferable, and the range of 0.003: 1 to 30: 1 is particularly preferable. The effect of this invention can be more effectively exhibited because the compounding ratio of tectorigenins and other components is within the above range.
本発明の肝機能改善剤は、必要に応じて、経口用として許容される添加剤や、テクトリゲニン類及び他成分以外の成分を添加して、公知の製剤方法によって製造することができる。 The liver function-improving agent of the present invention can be produced by a known preparation method by adding an additive that is acceptable for oral use, or components other than tectrigenins and other components, if necessary.
また、本発明の肝機能改善剤としては、テクトリゲニン類及び他成分を含有する肝機能改善用食品の他、食品に対してテクトリゲニン類及び他成分を添加して得た肝機能改善用食品を挙げることができ、例えば、通常の食品（天然の食品を含む）に比して本発明のテクトリゲニン類及び他成分含有量を増加させた食品や、本発明のテクトリゲニン類及び他成分を通常含まない食品に対してテクトリゲニン類及び他成分を添加した食品を挙げることができる。テクトリゲニン類及び他成分の添加は、それぞれの成分を別々に添加してもよいし、同時に添加してもよく、また、テクトリゲニン類及び他成分以外の他成分と共に添加してもよい。 In addition, the liver function-improving agent of the present invention includes foods for improving liver function obtained by adding tectorigenins and other ingredients to foods, as well as foods for improving liver functions containing tectorigenins and other ingredients. For example, a food with an increased content of tectrigenins and other components of the present invention as compared to normal foods (including natural foods), or a food that does not normally contain the tectrigenins and other components of the present invention The foodstuff which added tectorigenins and other components with respect to can be mentioned. Tectrigenins and other components may be added separately, or may be added at the same time, or may be added together with other components other than tectorigenins and other components.
本発明の肝機能改善剤の使用形態の一つとして、食品に添加することができ、食品としては、例えば、炭酸飲料、栄養飲料、果実飲料、乳酸飲料、スムージー、青汁等の飲料；アイスクリーム、アイスシャーベット、かき氷等の冷菓；そば、うどん、はるさめ、中華麺、即席麺等の麺類；飴、キャンディー、ガム、チョコレート、錠菓、スナック菓子、ビスケット、ゼリー、ジャム、クリーム、焼き菓子、パン等の菓子類；かまぼこ、ハム、ソーセージ等の水産・畜産加工食品；加工乳、発酵乳、ヨーグルト等の乳製品；サラダ油、てんぷら油、マーガリン、マヨネーズ、ショートニング、ホイップクリーム、ドレッシング等の油脂及びその加工食品；ソース、醤油等の調味料；カレー、シチュー、親子丼、お粥、雑炊、中華丼、かつ丼、天丼、牛丼、ハヤシライス、オムライス、おでん、マーボドーフ、餃子、シューマイ、ハンバーグ、ミートボール、各種ソース、各種スープ等のレトルトパウチ食品等を挙げることができる。 As one of the usage forms of the liver function improving agent of the present invention, it can be added to food. Examples of food include beverages such as carbonated beverages, nutritional beverages, fruit beverages, lactic acid beverages, smoothies, and green juices; ice Frozen sweets such as cream, ice sherbet, shaved ice, noodles such as buckwheat, udon, harusame, Chinese noodles, instant noodles, etc. Processed foods such as kamaboko, ham, sausage, etc .; Dairy products such as processed milk, fermented milk, yogurt; fats and oils such as salad oil, tempura oil, margarine, mayonnaise, shortening, whipped cream, dressing and the like Processed foods; seasonings such as sauces, soy sauce; curry, stew, oyakodon, rice cakes, miscellaneous cooking, Chinese rice cakes, bonito, heaven , Mention may be made of beef bowl, hashed rice, omelet, Oden, Mabodofu, dumplings, Shumai, hamburger, meatballs, various sources, the retort pouch foods such as various types of soup.
以下、本発明を実施例に基づき説明する。 Hereinafter, the present invention will be described based on examples.
［試験例］
テクトリゲニン類としては、植物から抽出したテクトリゲニン、テクトリジン及びＴＧＸＧの混合物を用いた。（テクトリゲニン：テクトリジン：ＴＧＸＧ＝５．４：３４．１：６０．５）
[Test example]
A mixture of tectorigenin, tectoridine and TGXG extracted from plants was used as the tectorigenins. (Tektrigenin: Tektridin: TGXG = 5.4: 34.1: 60.5)
［肝機能改善確認試験］
（サンプル液の調製）
ヒト肝癌由来細胞(HepG2)を10%FBS-DMEM（以下DMEM）により培養後、96well plateの各wellに4.0×104cells/wellの細胞密度で播種し、37℃、5%CO２インキュベーター内で24時間前培養した。
上記細胞にDMEMを用いて後述の表１〜６に記載する所定濃度に調製したサンプル液を200μLずつ添加し、5%CO２インキュベーター内で24時間培養した。
なお、上記サンプル液の調製において、他成分としてビタミンE、黒ショウガ、クルクミン、又はα-リポ酸を添加した際は、各被験物質DMSOに溶解し、DMSOの終濃度が0.25％になるように調製した。
[Liver function improvement confirmation test]
(Preparation of sample solution)
Human hepatoma-derived cells (HepG2) are cultured with 10% FBS-DMEM (hereinafter DMEM), then seeded at a cell density of 4.0 × 10 4 cells / well in each well of a 96-well plate, in a 37 ° C., 5% CO 2 incubator For 24 hours.
200 μL of a sample solution prepared to a predetermined concentration described in Tables 1 to 6 below was added to the cells using DMEM, and the cells were cultured in a 5% CO 2 incubator for 24 hours.
In the preparation of the sample solution, when vitamin E, black ginger, curcumin, or α-lipoic acid is added as another component, it is dissolved in each test substance DMSO so that the final concentration of DMSO is 0.25%. Prepared.
（測定方法）
サンプル液の培地を除去し、DMEMで30倍に希釈したCell Counting Kit-8溶液を150μＬ添加した。37℃、5％CO２インキュベーター内に静置し適度に発色させた後、450 nmにおける吸光度を測定した。
コントロールには、試験物質をDMSOに溶解したものに対しては0.25%DMSO含有DMEM、その他の試験物質に対してはDMEMを用いた。
(Measuring method)
The medium of the sample solution was removed, and 150 μL of Cell Counting Kit-8 solution diluted 30-fold with DMEM was added. After allowing to stand in a 37 ° C., 5% CO 2 incubator for color development appropriately, the absorbance at 450 nm was measured.
For the control, DMEM containing 0.25% DMSO was used for the test substance dissolved in DMSO, and DMEM was used for the other test substances.
各試験物質の肝細胞賦活率は下記の式にて算出した。
肝細胞賦活率（％）
% of control = (Data sample−Data blank) ／（Data control−Data blank）×100
（式中、Data sample：試験溶液(test)の蛍光強度
Data control：コントロール(test)の蛍光強度
Data blank：試験溶液(blank)の蛍光強度）
The hepatocyte activation rate of each test substance was calculated by the following formula.
Hepatocyte activation rate (%)
% of control = (Data sample-Data blank) / (Data control-Data blank) x 100
(In the formula, Data sample: Fluorescence intensity of test solution (test)
Data control: Fluorescence intensity of control (test)
Data blank: Fluorescence intensity of test solution (blank)
その結果を表１〜表６に示す。各試験区の肝細胞賦活率以外の数値はテクトリゲニン類又は他成分の最終濃度を示し、単位はいずれもμｇ／ｍＬである。各試験区の肝細胞賦活率はコントロールの肝細胞賦活率に対する変化値を示している。 The results are shown in Tables 1-6. Numerical values other than the hepatocyte activation rate in each test group indicate the final concentrations of tectrigenins or other components, and the unit is μg / mL. The hepatocyte activation rate of each test group shows a change value relative to the control hepatocyte activation rate.
なお、テクトリゲニン類を単独で用いた場合の肝細胞賦活率（変化値）と、他成分を単独で用いた場合の肝細胞賦活率（変化値）の和よりも、組み合わせて用いた場合の肝細胞賦活率（変化値）が１０ポイント以上増加した他成分をテクトリゲニン類との相乗効果ありとし、表１〜表６に記載した。 It should be noted that hepatocyte activation rate (change value) when tectrigenins are used alone and hepatocyte activation rate (change value) when other components are used alone, and liver when combined and used. Other components whose cell activation rate (change value) was increased by 10 points or more were regarded as having a synergistic effect with tectorigenins and are shown in Tables 1 to 6.
表１に記載された他成分はすべて市販されているものを用いた。 All other components listed in Table 1 were commercially available.
表２のヨモギは市販されているヨモギの粉砕末、黒ショウガは市販されている黒ショウガ根茎の６０％エタノール抽出物を用いた。また、ヨモギ及び黒ショウガ以外の他成分はすべて市販されているものを用いた。 The mugwort in Table 2 was a ground powder of mugwort, and black ginger was a commercially available 60% ethanol extract of black ginger rhizome. In addition, commercially available components other than mugwort and black ginger were used.
表３に記載された他成分はすべて市販されているものを用いた。 All other components listed in Table 3 were commercially available.
表４に記載された他成分はすべて市販されているものを用いた。 All the other components described in Table 4 were commercially available.
表５に記載された他成分はすべて市販されているものを用いた。なお、鉄は塩化鉄、モリブデンは塩化モリブデン、チタンは二酸化チタン、亜鉛はグルコン酸亜鉛を用いた。 All the other components described in Table 5 were commercially available. Iron was iron chloride, molybdenum was molybdenum chloride, titanium was titanium dioxide, and zinc was gluconate.
表６に記載された他成分はすべて市販されているものを用いた。 All other components listed in Table 6 were commercially available.
表１〜表６に示すように、テクトリゲニン類と本発明の特定の他成分を組み合わせることにより、肝細胞賦活率が相乗的に増加した。したがって、本発明の肝機能改善剤は肝血流の増加、胆汁分泌促進、肝臓組織呼吸促進、又はウィルス性・薬剤性・アルコール性肝障害抑制を目的として利用できる。 As shown in Tables 1 to 6, the hepatocyte activation rate was increased synergistically by combining tectorigenins and other specific components of the present invention. Therefore, the liver function improving agent of the present invention can be used for the purpose of increasing hepatic blood flow, promoting bile secretion, promoting liver tissue respiration, or suppressing viral / drug / alcoholic liver injury.
（比較例）
実施例と同じ手法を用いて、下記他成分の肝機能改善確認試験を行ったところ、ビタミン類であるビタミンＡ（テクトリゲニン）、植物素材である大麦若葉末、発酵関連素材である野菜発酵物、アミノ酸であるアルギニン、機能性添加剤であるカルシウム及び甘味料であるトレハロースについては、いずれもテクトリゲニン類を単独で用いた場合の肝細胞賦活率（変化値）と、他成分を単独で用いた場合の肝細胞賦活率（変化値）の和よりも、組み合わせて用いた場合の肝細胞賦活率（変化値）が１０ポイント以上増加せず、肝細胞賦活の相乗作用は確認されなかった。
(Comparative example)
Using the same technique as in the examples, a liver function improvement confirmation test of the following other components was performed. Vitamin A (tectigenin), plant material barley young leaf powder, fermentation related material vegetable fermented product, For arginine, which is an amino acid, calcium, which is a functional additive, and trehalose, which is a sweetener, the activation rate of hepatocytes (change value) when tectrigenin is used alone, and when other components are used alone The hepatocyte activation rate (change value) when used in combination did not increase by 10 points or more, and the synergistic effect of hepatocyte activation was not confirmed.
（配合例１：化粧水）
全体を１００質量部として、テクトリゲニン類 ０．０１質量部、ビタミンＢ２ ０．０１質量部、グリセリン １０質量部、ジグリセリン ３質量部、１、３−ブチレングリコール １２質量部、ペンチレングリコール ３質量部、ヒアルロン酸ナトリウム ０．１質量部、クエン酸 ０．０１質量部、クエン酸ナトリウム ０．０２質量部、キサンタンガム ０．１質量部、メチルパラベン ０．１５質量部、カルボマー ０．２質量部、水酸化ナトリウム ０．０３質量部及び水 残部を混合して、化粧水の態様で本発明の肝機能改善剤を調製した。
(Formulation example 1: lotion)
100 parts by weight as a whole, 0.01 parts by weight of tektrigenins, 0.01 parts by weight of vitamin B2, 10 parts by weight of glycerol, 3 parts by weight of diglycerol, 12 parts by weight of 1,3-butylene glycol, 3 parts by weight of pentylene glycol , Sodium hyaluronate 0.1 part, citric acid 0.01 part, sodium citrate 0.02 part, xanthan gum 0.1 part, methylparaben 0.15 part, carbomer 0.2 part, hydroxylation 0.03 parts by mass of sodium and the remaining water were mixed to prepare the liver function improving agent of the present invention in the form of a lotion.
（配合例２：シャンプー）
全体を１００質量部として、テクトリゲニン類 ０．０１質量部、ヨモギ葉エキス ０．０２質量部、ラウレス硫酸ナトリウム ７．５質量部、コカミドプロピルベタイン ４．２質量部、コカミドＤＥＡ ３質量部、１、３−ブチレングリコール ０．１質量部、ポリクオタニウム−１０ ０．２２５質量部、クエン酸 ０．１５質量部、クエン酸ナトリウム ０．０５質量部、フェノキシエタノール ０．９質量部及び水 残部を混合して、シャンプーの態様で本発明の肝機能改善剤を調製した。
(Formulation example 2: shampoo)
100 parts by mass as a whole, 0.01 parts by mass of tectorigenins, 0.02 parts by mass of mugwort leaf extract, 7.5 parts by mass of sodium laureth sulfate, 4.2 parts by mass of cocamidopropyl betaine, 3 parts by mass of cocamide DEA, 1 , 0.1 part by weight of 3-butylene glycol, 0.225 part by weight of polyquaternium-10, 0.15 part by weight of citric acid, 0.05 part by weight of sodium citrate, 0.9 part by weight of phenoxyethanol and the rest of water The liver function improving agent of the present invention was prepared in the form of a shampoo.
（配合例３：石鹸）
全体を１００質量部として、テクトリゲニン類 ０．５質量部、黒酢 ０．５重量部、グリセリン ２質量部、オリーブ油 １質量部、ＥＤＴＡ−４ナトリウム ０．１質量部、エチドロン酸４ナトリウム ０．２質量部及び石鹸素地 残部を混合及び固化することにより、石鹸の態様で本発明の肝機能改善剤を調製した。
(Formulation example 3: soap)
100 parts by mass as a whole, 0.5 parts by mass of tektrigenins, 0.5 parts by mass of black vinegar, 2 parts by mass of glycerin, 1 part by mass of olive oil, 0.1 parts by mass of EDTA-4 sodium, 4 sodium etidronate 0.2 The liver function improving agent of the present invention was prepared in the form of soap by mixing and solidifying the mass part and the remaining soap base.
（配合例４：乳液）
全体を１００質量部として、テクトリゲニン類 ０．１質量部、チロシン ０．１質量部、ショ糖脂肪酸エステル ３質量部、グリセリン １２質量部、スクアラン ６質量部、ジメチルシリコーンオイル ２４質量部、ポリプロピレングリコール １質量部、増粘剤 ０．０６質量部、フェノキシエタノール ０．２質量部、エタノール ５質量部、水酸化ナトリウム ０．０１質量部及び精製水 残部を混合して、乳液の態様で本発明の肝機能改善剤を調製した。
(Formulation example 4: emulsion)
100 parts by mass as a whole, tektrigenins 0.1 parts by mass, tyrosine 0.1 parts by mass, sucrose fatty acid ester 3 parts by mass, glycerin 12 parts by mass, squalane 6 parts by mass, dimethyl silicone oil 24 parts by mass, polypropylene glycol 1 Liver function of the present invention in the form of an emulsion by mixing parts by mass, 0.06 parts by mass of thickener, 0.2 parts by mass of phenoxyethanol, 5 parts by mass of ethanol, 0.01 parts by mass of sodium hydroxide, and the remainder of purified water. An improver was prepared.
（配合例５：化粧用クリーム）
全体を１００質量部として、テクトリゲニン類 ０．１質量部、クロロゲン酸 ０．１質量部、スクワラン １５．０質量部、ミリスチン酸オクチルドデシル ４．０質量部、水素添加大豆リン脂質 ０．２質量部、ブチルアルコール ２．４質量部、硬化油 １．５質量部、ステアリン酸 １．５質量部、親油型モノステアリン酸グリセリン １．５質量部、モノステアリン酸ポリグリセリル ０．５質量部、ベヘニルアルコール ０．８質量部、モノミリスチン酸ポリグリセリル ０．７質量部、サラシミツロウ ０．３質量部、ｄ−δ−トコフェロール ０．１質量部、メチルパラベン ０．３質量部、Ｃ１０〜３０アルキル変性カルボキシビニルポリマー ０．２質量部、カルボキシビニルポリマー ０．１質量部、１、３−ブタンジオール １８．０質量部、水酸化ナトリウム ０．１質量部及び精製水 残部を混合して、化粧用クリームの態様で本発明の肝機能改善剤を調製した。
(Formulation Example 5: Cosmetic cream)
100 parts by mass as a whole, tectrigenins 0.1 parts by mass, chlorogenic acid 0.1 parts by mass, squalane 15.0 parts by mass, octyldodecyl myristate 4.0 parts by mass, hydrogenated soybean phospholipid 0.2 parts by mass Butyl alcohol 2.4 parts by mass, hydrogenated oil 1.5 parts by mass, stearic acid 1.5 parts by mass, lipophilic glyceryl monostearate 1.5 parts by mass, polyglyceryl monostearate 0.5 parts by mass, behenyl alcohol 0 0.8 parts by mass, polyglyceryl monomyristate 0.7 parts by mass, beeswax 0.3 parts by mass, d-δ-tocopherol 0.1 parts by mass, methylparaben 0.3 parts by mass, C10-30 alkyl-modified carboxyvinyl polymer 0 .2 parts by weight, carboxyvinyl polymer 0.1 parts by weight, 1,3-butanediol 18.0 parts by weight By mixing 0.1 parts by mass of sodium hydroxide and purified water balance, liver function improving agent of the present invention was prepared in the manner of cosmetic creams.
（配合例６：パック剤）
全体を１００質量部として、テクトリゲニン類抽出物 ０．１質量部、アスパルテーム ０．０１質量部、ポリビニルアルコール ２０．０質量部、グリセリン ５．０質量部、エタノール ２０．０質量部、カオリン ６．０質量部、防腐剤 ０．２質量部、香料 ０．１質量部及び精製水 残部を混合して、パック剤の態様で本発明の肝機能改善剤を調製した。
(Formulation Example 6: Packing agent)
100 parts by mass as a whole, 0.1 parts by mass of tectorigenin extract, 0.01 parts by mass of aspartame, 20.0 parts by mass of polyvinyl alcohol, 5.0 parts by mass of glycerol, 20.0 parts by mass of ethanol, kaolin 6.0 The liver function improving agent of the present invention was prepared in the form of a pack agent by mixing parts by mass, 0.2 parts by mass of a preservative, 0.1 part by mass of a fragrance, and the remainder of purified water.
（配合例７：錠剤）
全体を１００質量部として、テクトリゲニン類粉末 ５質量部、パントテン酸ナトリウム ８質量部、ビタミンＢ１ ５質量部、結晶性セルロース ２０質量部、乳糖 ５０質量部、ステアリン酸マグネシウム ４質量部及びコーンスターチ 残部を混合及び打錠することにより、錠剤の態様で本発明の肝機能改善剤を調製した。
(Formulation Example 7: Tablet)
100 parts by mass as a whole, 5 parts by mass of tectorigenin powder, 8 parts by mass of sodium pantothenate, 5 parts by mass of vitamin B1, 20 parts by mass of crystalline cellulose, 50 parts by mass of lactose, 4 parts by mass of magnesium stearate and the remainder of corn starch And the liver function improving agent of this invention was prepared in the aspect of the tablet by tableting.
（配合例８：顆粒剤）
全体を１００質量部として、テクトリゲニン類粉末 ５質量部、黒ショウガ抽出物 １５質量部、乳糖 １０質量部、ステアリン酸カルシウム １質量部及び結晶セルロース 残部を混合及び顆粒化することにより、顆粒剤の態様で本発明の肝機能改善剤を調製した。
(Formulation Example 8: Granules)
By mixing and granulating 5 parts by mass of tectorigenin powder, 15 parts by mass of black ginger extract, 10 parts by mass of lactose, 1 part by mass of calcium stearate and the rest of crystalline cellulose, with 100 parts by mass as a whole. The liver function improving agent of the present invention was prepared.
（配合例９：カプセル剤）
全体を１００質量部として、テクトリゲニン類抽出物 ２．５質量部、穀物麹 ２０質量部、レシチン ８質量部及びオリーブ油 残部を混合して調製したものを内容液として、これをカプセル殻に内包することにより、カプセル剤の態様で本発明の肝機能改善剤を調製した。
(Formulation example 9: capsule)
The total amount is 100 parts by mass, and the tectigenin extract is mixed with 2.5 parts by mass, 20 parts by mass of cereal meal, 8 parts by mass of lecithin, and the remainder of olive oil. Thus, the liver function improving agent of the present invention was prepared in the form of a capsule.
（配合例１０：液剤）
全体を１００質量部として、テクトリゲニン類粉末 ０．３３質量部、Ｌ−アラニン ０．１質量部、果糖ブドウ糖液糖 １０質量部、クエン酸 １質量部、安息香酸ナトリウム ０．０２質量部、香料 ２質量部、スクラロース ０．０５質量部、アセスルファムカリウム ０．０３質量部及び精製水 残部を混合して、液剤の態様で本発明の肝機能改善剤を調製した。
(Formulation example 10: liquid agent)
100 parts by mass as a whole, 0.33 parts by mass of tectorigenin powder, 0.1 parts by mass of L-alanine, 10 parts by mass of fructose-glucose liquid sugar, 1 part by mass of citric acid, 0.02 parts by mass of sodium benzoate, fragrance 2 The liver function-improving agent of the present invention was prepared in a liquid form by mixing parts by mass, 0.05 parts by mass of sucralose, 0.03 parts by mass of acesulfame potassium, and the remainder of purified water.
Claims (4)
（ａ）ビタミンＢ２、パントテン酸ナトリウム、ビオチン、ビタミンＥから選ばれる少なくとも１種のビタミン類
（ｂ）ヨモギ、黒ショウガ（Ｋａｅｍｐｆｅｒｉａ ｐａｒｖｉｆｌｏｒａ）、米ぬか、米胚芽から選ばれる少なくとも１種の植物素材
（ｃ）穀物麹、黒酢、小麦ふすま発酵エキス末、もろみ酢、ビール酵母から選ばれる少なくとも１種の発酵関連素材
（ｄ）アラニン、イソロイシン、リジン、プロリン、チロシンから選ばれる少なくとも１種のアミノ酸（塩を含む）
（ｅ）鉄、モリブデン、亜鉛、チタン、没食子酸、クロロゲン酸、クルクミン、カフェイン、Ｌ−カルニチン、α‐リポ酸から選ばれる少なくとも１種の機能性添加剤
（ｆ）アスパルテーム、麦芽糖、フラクトオリゴ糖から選ばれる少なくとも１種の甘味料 A liver function-improving agent comprising tectigenin and at least one component selected from the group consisting of the following (a) to (f):
(A) At least one vitamin selected from vitamin B2, sodium pantothenate, biotin, and vitamin E (b) At least one plant material selected from mugwort, black ginger (Kaempferia parviflora), rice bran, and rice germ (c ) At least one fermentation-related material selected from cereal meal, black vinegar, wheat bran fermentation extract powder, moromi vinegar, brewer's yeast (d) at least one amino acid (salt) selected from alanine, isoleucine, lysine, proline, tyrosine including)
(E) At least one functional additive selected from iron, molybdenum, zinc, titanium, gallic acid, chlorogenic acid, curcumin, caffeine, L-carnitine, α-lipoic acid (f) aspartame, maltose, fructooligosaccharide At least one sweetener selected from
（ａ）ビタミンＢ２、パントテン酸ナトリウム、ビオチン、ビタミンＥから選ばれる少なくとも１種のビタミン類
（ｂ）ヨモギ、黒ショウガ（Ｋａｅｍｐｆｅｒｉａ ｐａｒｖｉｆｌｏｒａ）、米ぬか、米胚芽から選ばれる少なくとも１種の植物素材
（ｃ）穀物麹、黒酢、小麦ふすま発酵エキス末、もろみ酢、ビール酵母から選ばれる少なくとも１種の発酵関連素材
（ｄ）アラニン、イソロイシン、リジン、プロリン、チロシンから選ばれる少なくとも１種のアミノ酸（塩を含む）
（ｅ）鉄、モリブデン、亜鉛、チタン、没食子酸、クロロゲン酸、クルクミン、カフェイン、Ｌ−カルニチン、α‐リポ酸から選ばれる少なくとも１種の機能性添加剤
（ｆ）アスパルテーム、麦芽糖、フラクトオリゴ糖から選ばれる少なくとも１種の甘味料 A composition for improving liver function, comprising tektrigenins and at least one component selected from the group consisting of the following (a) to (f):
(A) At least one vitamin selected from vitamin B2, sodium pantothenate, biotin, and vitamin E (b) At least one plant material selected from mugwort, black ginger (Kaempferia parviflora), rice bran, and rice germ (c ) At least one fermentation-related material selected from cereal meal, black vinegar, wheat bran fermentation extract powder, moromi vinegar, brewer's yeast (d) at least one amino acid (salt) selected from alanine, isoleucine, lysine, proline, tyrosine including)
(E) At least one functional additive selected from iron, molybdenum, zinc, titanium, gallic acid, chlorogenic acid, curcumin, caffeine, L-carnitine, α-lipoic acid (f) aspartame, maltose, fructooligosaccharide At least one sweetener selected from
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| JP2022069053A JP2022089939A (en) | 2016-03-16 | 2022-04-19 | Liver function improver |
| JP2023210781A JP2024023667A (en) | 2016-03-16 | 2023-12-14 | Liver function improver |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN108813500A (en) * | 2018-05-28 | 2018-11-16 | 江西天元药业有限公司 | With tonifying middle-Jiao and Qi, nourishing blood and tranquilization and the health honey paste for adjusting function of human body |
| JP2021158984A (en) * | 2020-03-31 | 2021-10-11 | 株式会社東洋新薬 | Oral composition |
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| JP2006206557A (en) * | 2005-01-31 | 2006-08-10 | Ota Isan:Kk | Alcohol-induced disease-preventing or treating agent and method for preparing the same |
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| JPS6468318A (en) * | 1987-09-08 | 1989-03-14 | Ota Isan Kk | Prophylactic improver or hepatic function disorder |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108813500A (en) * | 2018-05-28 | 2018-11-16 | 江西天元药业有限公司 | With tonifying middle-Jiao and Qi, nourishing blood and tranquilization and the health honey paste for adjusting function of human body |
| CN108813500B (en) * | 2018-05-28 | 2021-09-21 | 江西天元药业有限公司 | Health-preserving honey paste with effects of tonifying middle-jiao and Qi, nourishing blood and soothing nerves and regulating human body functions |
| JP2021158984A (en) * | 2020-03-31 | 2021-10-11 | 株式会社東洋新薬 | Oral composition |
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