CN114557938A - Composition with brightening, compacting and anti-wrinkle functions and preparation method and application thereof - Google Patents
Composition with brightening, compacting and anti-wrinkle functions and preparation method and application thereof Download PDFInfo
- Publication number
- CN114557938A CN114557938A CN202210122777.XA CN202210122777A CN114557938A CN 114557938 A CN114557938 A CN 114557938A CN 202210122777 A CN202210122777 A CN 202210122777A CN 114557938 A CN114557938 A CN 114557938A
- Authority
- CN
- China
- Prior art keywords
- extract
- composition
- brightening
- skin
- wrinkle
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000000203 mixture Substances 0.000 title claims abstract description 53
- 238000005282 brightening Methods 0.000 title claims abstract description 35
- 230000006870 function Effects 0.000 title claims abstract description 30
- 230000001153 anti-wrinkle effect Effects 0.000 title claims abstract description 29
- 238000002360 preparation method Methods 0.000 title abstract description 16
- 239000011347 resin Substances 0.000 claims abstract description 44
- 229920005989 resin Polymers 0.000 claims abstract description 44
- 235000006040 Prunus persica var persica Nutrition 0.000 claims abstract description 34
- 244000144730 Amygdalus persica Species 0.000 claims abstract description 33
- 239000002537 cosmetic Substances 0.000 claims abstract description 22
- 230000037303 wrinkles Effects 0.000 claims abstract description 19
- 241001558929 Sclerotium <basidiomycota> Species 0.000 claims abstract description 9
- 244000193174 agave Species 0.000 claims abstract description 9
- 241001619461 Poria <basidiomycete fungus> Species 0.000 claims abstract description 3
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 claims description 30
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 21
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 20
- 235000007340 Hordeum vulgare Nutrition 0.000 claims description 16
- 238000001914 filtration Methods 0.000 claims description 10
- 239000007788 liquid Substances 0.000 claims description 10
- 239000001509 sodium citrate Substances 0.000 claims description 10
- NLJMYIDDQXHKNR-UHFFFAOYSA-K sodium citrate Chemical compound O.O.[Na+].[Na+].[Na+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O NLJMYIDDQXHKNR-UHFFFAOYSA-K 0.000 claims description 10
- 244000197580 Poria cocos Species 0.000 claims description 9
- 235000008599 Poria cocos Nutrition 0.000 claims description 9
- JYJIGFIDKWBXDU-MNNPPOADSA-N inulin Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)OC[C@]1(OC[C@]2(OC[C@]3(OC[C@]4(OC[C@]5(OC[C@]6(OC[C@]7(OC[C@]8(OC[C@]9(OC[C@]%10(OC[C@]%11(OC[C@]%12(OC[C@]%13(OC[C@]%14(OC[C@]%15(OC[C@]%16(OC[C@]%17(OC[C@]%18(OC[C@]%19(OC[C@]%20(OC[C@]%21(OC[C@]%22(OC[C@]%23(OC[C@]%24(OC[C@]%25(OC[C@]%26(OC[C@]%27(OC[C@]%28(OC[C@]%29(OC[C@]%30(OC[C@]%31(OC[C@]%32(OC[C@]%33(OC[C@]%34(OC[C@]%35(OC[C@]%36(O[C@@H]%37[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O%37)O)[C@H]([C@H](O)[C@@H](CO)O%36)O)[C@H]([C@H](O)[C@@H](CO)O%35)O)[C@H]([C@H](O)[C@@H](CO)O%34)O)[C@H]([C@H](O)[C@@H](CO)O%33)O)[C@H]([C@H](O)[C@@H](CO)O%32)O)[C@H]([C@H](O)[C@@H](CO)O%31)O)[C@H]([C@H](O)[C@@H](CO)O%30)O)[C@H]([C@H](O)[C@@H](CO)O%29)O)[C@H]([C@H](O)[C@@H](CO)O%28)O)[C@H]([C@H](O)[C@@H](CO)O%27)O)[C@H]([C@H](O)[C@@H](CO)O%26)O)[C@H]([C@H](O)[C@@H](CO)O%25)O)[C@H]([C@H](O)[C@@H](CO)O%24)O)[C@H]([C@H](O)[C@@H](CO)O%23)O)[C@H]([C@H](O)[C@@H](CO)O%22)O)[C@H]([C@H](O)[C@@H](CO)O%21)O)[C@H]([C@H](O)[C@@H](CO)O%20)O)[C@H]([C@H](O)[C@@H](CO)O%19)O)[C@H]([C@H](O)[C@@H](CO)O%18)O)[C@H]([C@H](O)[C@@H](CO)O%17)O)[C@H]([C@H](O)[C@@H](CO)O%16)O)[C@H]([C@H](O)[C@@H](CO)O%15)O)[C@H]([C@H](O)[C@@H](CO)O%14)O)[C@H]([C@H](O)[C@@H](CO)O%13)O)[C@H]([C@H](O)[C@@H](CO)O%12)O)[C@H]([C@H](O)[C@@H](CO)O%11)O)[C@H]([C@H](O)[C@@H](CO)O%10)O)[C@H]([C@H](O)[C@@H](CO)O9)O)[C@H]([C@H](O)[C@@H](CO)O8)O)[C@H]([C@H](O)[C@@H](CO)O7)O)[C@H]([C@H](O)[C@@H](CO)O6)O)[C@H]([C@H](O)[C@@H](CO)O5)O)[C@H]([C@H](O)[C@@H](CO)O4)O)[C@H]([C@H](O)[C@@H](CO)O3)O)[C@H]([C@H](O)[C@@H](CO)O2)O)[C@@H](O)[C@H](O)[C@@H](CO)O1 JYJIGFIDKWBXDU-MNNPPOADSA-N 0.000 claims description 8
- 238000001035 drying Methods 0.000 claims description 5
- 238000007710 freezing Methods 0.000 claims description 5
- 230000008014 freezing Effects 0.000 claims description 5
- 238000002156 mixing Methods 0.000 claims description 5
- 239000002244 precipitate Substances 0.000 claims description 5
- 238000002791 soaking Methods 0.000 claims description 5
- 239000006228 supernatant Substances 0.000 claims description 5
- 239000002904 solvent Substances 0.000 claims description 4
- 241001261506 Undaria pinnatifida Species 0.000 claims description 3
- 239000006071 cream Substances 0.000 claims description 2
- 230000002950 deficient Effects 0.000 claims description 2
- 235000015110 jellies Nutrition 0.000 claims description 2
- 239000008274 jelly Substances 0.000 claims description 2
- 239000006210 lotion Substances 0.000 claims description 2
- 229920005862 polyol Polymers 0.000 claims description 2
- 150000003077 polyols Chemical class 0.000 claims description 2
- 239000000243 solution Substances 0.000 claims description 2
- 240000004246 Agave americana Species 0.000 claims 1
- 235000008754 Agave americana Nutrition 0.000 claims 1
- 240000005979 Hordeum vulgare Species 0.000 claims 1
- 230000000694 effects Effects 0.000 abstract description 11
- 230000015572 biosynthetic process Effects 0.000 abstract description 7
- 238000003786 synthesis reaction Methods 0.000 abstract description 7
- 230000004936 stimulating effect Effects 0.000 abstract description 6
- 102000008186 Collagen Human genes 0.000 abstract description 5
- 108010035532 Collagen Proteins 0.000 abstract description 5
- 229920001436 collagen Polymers 0.000 abstract description 5
- 239000002994 raw material Substances 0.000 abstract description 5
- 241000721047 Danaus plexippus Species 0.000 abstract description 4
- 229920002683 Glycosaminoglycan Polymers 0.000 abstract description 3
- 230000008901 benefit Effects 0.000 abstract description 3
- 210000001339 epidermal cell Anatomy 0.000 abstract description 3
- 239000004519 grease Substances 0.000 abstract description 3
- 230000001502 supplementing effect Effects 0.000 abstract description 3
- 235000012041 food component Nutrition 0.000 abstract description 2
- 150000005846 sugar alcohols Polymers 0.000 abstract description 2
- 239000002562 thickening agent Substances 0.000 abstract description 2
- 230000000052 comparative effect Effects 0.000 description 57
- 210000003491 skin Anatomy 0.000 description 32
- 238000012360 testing method Methods 0.000 description 22
- 241000209219 Hordeum Species 0.000 description 15
- 239000002884 skin cream Substances 0.000 description 15
- 230000006872 improvement Effects 0.000 description 8
- 230000037394 skin elasticity Effects 0.000 description 7
- 239000000523 sample Substances 0.000 description 6
- 229940006284 undaria pinnatifida extract Drugs 0.000 description 6
- 235000013339 cereals Nutrition 0.000 description 5
- 238000011156 evaluation Methods 0.000 description 5
- 239000000902 placebo Substances 0.000 description 5
- 229940068196 placebo Drugs 0.000 description 5
- 239000000047 product Substances 0.000 description 5
- 239000004480 active ingredient Substances 0.000 description 4
- 229940069780 barley extract Drugs 0.000 description 4
- 230000001815 facial effect Effects 0.000 description 4
- 210000001061 forehead Anatomy 0.000 description 4
- BTCSSZJGUNDROE-UHFFFAOYSA-N gamma-aminobutyric acid Chemical compound NCCCC(O)=O BTCSSZJGUNDROE-UHFFFAOYSA-N 0.000 description 4
- 230000002829 reductive effect Effects 0.000 description 4
- 229920001202 Inulin Polymers 0.000 description 3
- CDQSJQSWAWPGKG-UHFFFAOYSA-N butane-1,1-diol Chemical compound CCCC(O)O CDQSJQSWAWPGKG-UHFFFAOYSA-N 0.000 description 3
- 229940029339 inulin Drugs 0.000 description 3
- 108090000623 proteins and genes Proteins 0.000 description 3
- 150000003648 triterpenes Chemical class 0.000 description 3
- 230000002087 whitening effect Effects 0.000 description 3
- OGNSCSPNOLGXSM-UHFFFAOYSA-N (+/-)-DABA Natural products NCCC(N)C(O)=O OGNSCSPNOLGXSM-UHFFFAOYSA-N 0.000 description 2
- KIUKXJAPPMFGSW-DNGZLQJQSA-N (2S,3S,4S,5R,6R)-6-[(2S,3R,4R,5S,6R)-3-Acetamido-2-[(2S,3S,4R,5R,6R)-6-[(2R,3R,4R,5S,6R)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylic acid Chemical group CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 KIUKXJAPPMFGSW-DNGZLQJQSA-N 0.000 description 2
- 102000010637 Aquaporins Human genes 0.000 description 2
- 244000298479 Cichorium intybus Species 0.000 description 2
- 235000007542 Cichorium intybus Nutrition 0.000 description 2
- 102000016942 Elastin Human genes 0.000 description 2
- 108010014258 Elastin Proteins 0.000 description 2
- 241000233866 Fungi Species 0.000 description 2
- 235000001188 Peltandra virginica Nutrition 0.000 description 2
- 208000004880 Polyuria Diseases 0.000 description 2
- 230000001914 calming effect Effects 0.000 description 2
- 238000006243 chemical reaction Methods 0.000 description 2
- 239000003153 chemical reaction reagent Substances 0.000 description 2
- 238000000354 decomposition reaction Methods 0.000 description 2
- 230000035619 diuresis Effects 0.000 description 2
- 239000003814 drug Substances 0.000 description 2
- 229920002549 elastin Polymers 0.000 description 2
- 235000013305 food Nutrition 0.000 description 2
- 229960003692 gamma aminobutyric acid Drugs 0.000 description 2
- 150000004676 glycans Chemical class 0.000 description 2
- 229920002674 hyaluronan Polymers 0.000 description 2
- 229960003160 hyaluronic acid Drugs 0.000 description 2
- 230000001939 inductive effect Effects 0.000 description 2
- 230000002401 inhibitory effect Effects 0.000 description 2
- 239000000463 material Substances 0.000 description 2
- 229920001282 polysaccharide Polymers 0.000 description 2
- 239000005017 polysaccharide Substances 0.000 description 2
- 102000004169 proteins and genes Human genes 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
- 235000013529 tequila Nutrition 0.000 description 2
- 238000010998 test method Methods 0.000 description 2
- QURCVMIEKCOAJU-UHFFFAOYSA-N trans-isoferulic acid Natural products COC1=CC=C(C=CC(O)=O)C=C1O QURCVMIEKCOAJU-UHFFFAOYSA-N 0.000 description 2
- 235000013343 vitamin Nutrition 0.000 description 2
- 239000011782 vitamin Substances 0.000 description 2
- 229940088594 vitamin Drugs 0.000 description 2
- 229930003231 vitamin Natural products 0.000 description 2
- FYGDTMLNYKFZSV-URKRLVJHSA-N (2s,3r,4s,5s,6r)-2-[(2r,4r,5r,6s)-4,5-dihydroxy-2-(hydroxymethyl)-6-[(2r,4r,5r,6s)-4,5,6-trihydroxy-2-(hydroxymethyl)oxan-3-yl]oxyoxan-3-yl]oxy-6-(hydroxymethyl)oxane-3,4,5-triol Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1OC1[C@@H](CO)O[C@@H](OC2[C@H](O[C@H](O)[C@H](O)[C@H]2O)CO)[C@H](O)[C@H]1O FYGDTMLNYKFZSV-URKRLVJHSA-N 0.000 description 1
- QBLFZIBJXUQVRF-UHFFFAOYSA-N (4-bromophenyl)boronic acid Chemical compound OB(O)C1=CC=C(Br)C=C1 QBLFZIBJXUQVRF-UHFFFAOYSA-N 0.000 description 1
- KSEBMYQBYZTDHS-HWKANZROSA-M (E)-Ferulic acid Natural products COC1=CC(\C=C\C([O-])=O)=CC=C1O KSEBMYQBYZTDHS-HWKANZROSA-M 0.000 description 1
- 206010067484 Adverse reaction Diseases 0.000 description 1
- 240000003498 Agave tequilana Species 0.000 description 1
- 235000005451 Agave tequilana Nutrition 0.000 description 1
- 108010063290 Aquaporins Proteins 0.000 description 1
- 241000894006 Bacteria Species 0.000 description 1
- 229920002498 Beta-glucan Polymers 0.000 description 1
- 102000029816 Collagenase Human genes 0.000 description 1
- 108060005980 Collagenase Proteins 0.000 description 1
- 241000196324 Embryophyta Species 0.000 description 1
- 206010015150 Erythema Diseases 0.000 description 1
- 108010003272 Hyaluronate lyase Proteins 0.000 description 1
- 102000001974 Hyaluronidases Human genes 0.000 description 1
- QURCVMIEKCOAJU-HWKANZROSA-N Isoferulic acid Natural products COC1=CC=C(\C=C\C(O)=O)C=C1O QURCVMIEKCOAJU-HWKANZROSA-N 0.000 description 1
- 241000218378 Magnolia Species 0.000 description 1
- 206010028980 Neoplasm Diseases 0.000 description 1
- 206010030113 Oedema Diseases 0.000 description 1
- 102000016387 Pancreatic elastase Human genes 0.000 description 1
- 108010067372 Pancreatic elastase Proteins 0.000 description 1
- 235000008331 Pinus X rigitaeda Nutrition 0.000 description 1
- 235000011613 Pinus brutia Nutrition 0.000 description 1
- 241000018646 Pinus brutia Species 0.000 description 1
- 241000209504 Poaceae Species 0.000 description 1
- 238000012356 Product development Methods 0.000 description 1
- 241001631271 Prunus fasciculata Species 0.000 description 1
- 240000005809 Prunus persica Species 0.000 description 1
- 208000003251 Pruritus Diseases 0.000 description 1
- 235000004789 Rosa xanthina Nutrition 0.000 description 1
- 241000220222 Rosaceae Species 0.000 description 1
- 241000264279 Sargassum fusiforme Species 0.000 description 1
- 206010040914 Skin reaction Diseases 0.000 description 1
- QAOWNCQODCNURD-UHFFFAOYSA-L Sulfate Chemical compound [O-]S([O-])(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-L 0.000 description 1
- 208000024780 Urticaria Diseases 0.000 description 1
- 230000001133 acceleration Effects 0.000 description 1
- 206010000496 acne Diseases 0.000 description 1
- 230000009471 action Effects 0.000 description 1
- 230000002411 adverse Effects 0.000 description 1
- 230000006838 adverse reaction Effects 0.000 description 1
- 230000002776 aggregation Effects 0.000 description 1
- 238000004220 aggregation Methods 0.000 description 1
- WQZGKKKJIJFFOK-PHYPRBDBSA-N alpha-D-galactose Chemical compound OC[C@H]1O[C@H](O)[C@H](O)[C@@H](O)[C@H]1O WQZGKKKJIJFFOK-PHYPRBDBSA-N 0.000 description 1
- 230000003712 anti-aging effect Effects 0.000 description 1
- PYMYPHUHKUWMLA-WDCZJNDASA-N arabinose Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)C=O PYMYPHUHKUWMLA-WDCZJNDASA-N 0.000 description 1
- PYMYPHUHKUWMLA-UHFFFAOYSA-N arabinose Natural products OCC(O)C(O)C(O)C=O PYMYPHUHKUWMLA-UHFFFAOYSA-N 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- SRBFZHDQGSBBOR-UHFFFAOYSA-N beta-D-Pyranose-Lyxose Natural products OC1COC(O)C(O)C1O SRBFZHDQGSBBOR-UHFFFAOYSA-N 0.000 description 1
- 230000004071 biological effect Effects 0.000 description 1
- 230000008859 change Effects 0.000 description 1
- 239000011248 coating agent Substances 0.000 description 1
- 238000000576 coating method Methods 0.000 description 1
- 229960002424 collagenase Drugs 0.000 description 1
- 239000012141 concentrate Substances 0.000 description 1
- 235000009508 confectionery Nutrition 0.000 description 1
- 201000010251 cutis laxa Diseases 0.000 description 1
- 210000004207 dermis Anatomy 0.000 description 1
- 238000004945 emulsification Methods 0.000 description 1
- 230000002708 enhancing effect Effects 0.000 description 1
- 238000003912 environmental pollution Methods 0.000 description 1
- 210000002615 epidermis Anatomy 0.000 description 1
- 231100000321 erythema Toxicity 0.000 description 1
- 150000002148 esters Chemical class 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- KSEBMYQBYZTDHS-HWKANZROSA-N ferulic acid Chemical compound COC1=CC(\C=C\C(O)=O)=CC=C1O KSEBMYQBYZTDHS-HWKANZROSA-N 0.000 description 1
- 229940114124 ferulic acid Drugs 0.000 description 1
- KSEBMYQBYZTDHS-UHFFFAOYSA-N ferulic acid Natural products COC1=CC(C=CC(O)=O)=CC=C1O KSEBMYQBYZTDHS-UHFFFAOYSA-N 0.000 description 1
- 235000001785 ferulic acid Nutrition 0.000 description 1
- 239000000835 fiber Substances 0.000 description 1
- 235000013312 flour Nutrition 0.000 description 1
- 235000011389 fruit/vegetable juice Nutrition 0.000 description 1
- 229930182830 galactose Natural products 0.000 description 1
- 230000036449 good health Effects 0.000 description 1
- 230000036541 health Effects 0.000 description 1
- 229960002773 hyaluronidase Drugs 0.000 description 1
- 230000036571 hydration Effects 0.000 description 1
- 238000006703 hydration reaction Methods 0.000 description 1
- 230000036039 immunity Effects 0.000 description 1
- 230000005764 inhibitory process Effects 0.000 description 1
- 229910052500 inorganic mineral Inorganic materials 0.000 description 1
- 229910017053 inorganic salt Inorganic materials 0.000 description 1
- 230000007794 irritation Effects 0.000 description 1
- 230000007803 itching Effects 0.000 description 1
- 235000004213 low-fat Nutrition 0.000 description 1
- 238000007433 macroscopic evaluation Methods 0.000 description 1
- 230000035800 maturation Effects 0.000 description 1
- 238000000034 method Methods 0.000 description 1
- 235000010755 mineral Nutrition 0.000 description 1
- 239000011707 mineral Substances 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 230000003020 moisturizing effect Effects 0.000 description 1
- 239000013642 negative control Substances 0.000 description 1
- 210000005036 nerve Anatomy 0.000 description 1
- 231100000252 nontoxic Toxicity 0.000 description 1
- 230000003000 nontoxic effect Effects 0.000 description 1
- 235000015097 nutrients Nutrition 0.000 description 1
- 235000016709 nutrition Nutrition 0.000 description 1
- 230000035764 nutrition Effects 0.000 description 1
- 230000003071 parasitic effect Effects 0.000 description 1
- 230000000144 pharmacologic effect Effects 0.000 description 1
- 150000002989 phenols Chemical class 0.000 description 1
- 230000008635 plant growth Effects 0.000 description 1
- 239000000843 powder Substances 0.000 description 1
- 238000004321 preservation Methods 0.000 description 1
- 230000001681 protective effect Effects 0.000 description 1
- YQUVCSBJEUQKSH-UHFFFAOYSA-N protochatechuic acid Natural products OC(=O)C1=CC=C(O)C(O)=C1 YQUVCSBJEUQKSH-UHFFFAOYSA-N 0.000 description 1
- 230000005855 radiation Effects 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 238000012827 research and development Methods 0.000 description 1
- 210000000582 semen Anatomy 0.000 description 1
- 230000005808 skin problem Effects 0.000 description 1
- 230000035483 skin reaction Effects 0.000 description 1
- 231100000430 skin reaction Toxicity 0.000 description 1
- 210000000952 spleen Anatomy 0.000 description 1
- 238000009210 therapy by ultrasound Methods 0.000 description 1
- 229940126680 traditional chinese medicines Drugs 0.000 description 1
- WKOLLVMJNQIZCI-UHFFFAOYSA-N vanillic acid Chemical compound COC1=CC(C(O)=O)=CC=C1O WKOLLVMJNQIZCI-UHFFFAOYSA-N 0.000 description 1
- TUUBOHWZSQXCSW-UHFFFAOYSA-N vanillic acid Natural products COC1=CC(O)=CC(C(O)=O)=C1 TUUBOHWZSQXCSW-UHFFFAOYSA-N 0.000 description 1
- 150000003722 vitamin derivatives Chemical class 0.000 description 1
Images
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9794—Liliopsida [monocotyledons]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9706—Algae
- A61K8/9711—Phaeophycota or Phaeophyta [brown algae], e.g. Fucus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9728—Fungi, e.g. yeasts
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9789—Magnoliopsida [dicotyledons]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/008—Preparations for oily skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/02—Preparations for care of the skin for chemically bleaching or whitening the skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/08—Anti-ageing preparations
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/59—Mixtures
- A61K2800/592—Mixtures of compounds complementing their respective functions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/59—Mixtures
- A61K2800/592—Mixtures of compounds complementing their respective functions
- A61K2800/5922—At least two compounds being classified in the same subclass of A61K8/18
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/74—Biological properties of particular ingredients
- A61K2800/78—Enzyme modulators, e.g. Enzyme agonists
- A61K2800/782—Enzyme inhibitors; Enzyme antagonists
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/80—Process related aspects concerning the preparation of the cosmetic composition or the storage or application thereof
- A61K2800/805—Corresponding aspects not provided for by any of codes A61K2800/81 - A61K2800/95
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/80—Process related aspects concerning the preparation of the cosmetic composition or the storage or application thereof
- A61K2800/82—Preparation or application process involves sonication or ultrasonication
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Biotechnology (AREA)
- Engineering & Computer Science (AREA)
- Mycology (AREA)
- Microbiology (AREA)
- Birds (AREA)
- Epidemiology (AREA)
- Botany (AREA)
- Dermatology (AREA)
- Gerontology & Geriatric Medicine (AREA)
- Cosmetics (AREA)
Abstract
The invention belongs to the technical field of skin care compositions, and particularly relates to a composition with brightening, firming and anti-wrinkle functions, and a preparation method and application thereof. The composition comprises the following components: folium agaves Sisalanae extract, thallus laminariae extract, peach resin extract, fructus Hordei vulgaris extract and Poria sclerotium extract; by utilizing the formula principle of 'monarch, minister, assistant and guide', the components are mutually blended and synergized, and the purposes of brightening, compacting and resisting wrinkles are achieved in the aspects of controlling oil, recovering the natural moisture content of skin, stimulating the synthesis of mucopolysaccharide, stimulating the synthesis of collagen, accelerating the renewal of epidermal cells, supplementing skin nutritional components and the like; the skin care product is applied to preparing cosmetics with brightening, firming and anti-wrinkle functions, improves the extensibility, silky feeling and powdery feeling of the cosmetics, forms a layer of velvet-like net on skin together with common raw materials of the cosmetics, such as grease, polyalcohol, thickening agent and the like, and has the advantages of elegant skin feeling, safety, high efficiency, mildness, multiple effects and high cost performance after use.
Description
Technical Field
The invention belongs to the technical field of skin care compositions, and particularly relates to a composition with brightening, tightening and anti-wrinkle functions, and a preparation method and application thereof.
Background
In recent years, with the acceleration of the pace of life and work of people and the aggravation of environmental pollution, people face more and more skin problems, especially the appearance of problems such as skin darkness, skin laxity, wrinkles and the like, and cosmetics with the functions of brightening, firming and anti-wrinkle become a hot spot in the field of skin care product development. With the increasingly mature consumption concept of people, the focus of consumers on the functional cosmetics is not only on the efficacy, but also on the safety. Compared with chemical whitening and anti-aging components with safety risks such as irritation, the natural components have the advantages of safety, mildness, durability, high efficiency and the like, and become a great trend in research and development of the existing functional cosmetics.
Disclosure of Invention
Aiming at the problems, the invention aims to provide a composition with brightening, firming and anti-wrinkle functions and a preparation method and application thereof, and by utilizing the formula principle of monarch, minister, assistant and guide, all components are mutually blended and synergized, so that the purposes of brightening, firming and anti-wrinkle are achieved in the aspects of controlling oil, recovering the natural moisture content of skin, stimulating the synthesis of mucopolysaccharide, stimulating the synthesis of collagen, accelerating the renewal of epidermal cells, supplementing skin nutrient components and the like.
The technical content of the invention is as follows:
the invention provides a composition with functions of brightening, firming and resisting wrinkles, which comprises the following components: folium agaves Sisalanae extract, thallus laminariae extract, peach resin extract, fructus Hordei vulgaris extract and Poria sclerotium extract;
the weight percentage of the Taikui agave leaf extract is 1-10%, the weight percentage of the undaria pinnatifida extract is 1-10%, the weight percentage of the peach resin extract is 1-10%, the weight percentage of the barley extract is 1-10%, the weight percentage of the poria cocos sclerotium extract is 1-10%, and the balance is solvent;
the tequila agave extract is multi-branched agave inulin, and the number of sugar groups is 6-29;
the preparation of the peach resin extract comprises the following steps: soaking resin secreted from peach tree bark in 50-70 wt% sodium citrate solution at 50-60 ℃ for softening, then carrying out ultrasonic microwave with the ultrasonic frequency of 40-50 kHz and the power of 80-90W, carrying out ultrasonic treatment for 10-15 min for 1-2 times, filtering to remove water, mixing the resin with NaOH with the concentration of 8-10% and ethanol with the concentration of 60-70%, carrying out ultrasonic microwave operation under the same conditions again, placing in a refrigerator for 24 hours, taking out and filtering to obtain precipitate, dissolving with water to obtain supernatant, freezing, and drying to obtain the peach tree resin extract;
The solid-to-liquid ratio of the resin to the sodium citrate solution is 1: (1-2) mg/mL;
and the mixed solid-liquid ratio of the filtered resin to NaOH and ethanol is 1: (1-2): (1-2) mg/mL;
the Taikulan magnolia leaf extract is rich in inulin, has an inhibition effect on hyaluronidase, can effectively inhibit the decomposition of hyaluronic acid, and can increase the water content of the horny layer by coating; has inhibitory effect on elastase and collagenase activity, and can effectively inhibit decomposition of skin elastin and collagen, thereby having skin moisturizing and tightening effects.
The undaria pinnatifida extract is rich in galactofucan sulfate, also called undaria pinnatifida ester, and the concentrate can reactivate 14 genes related to elastin, collagen and hyaluronic acid synthesis, maturation, aggregation and linkage, restore the skin vitality and enable the skin to be younger.
The peach resin is resin secreted from barks of peaches or wild peaches in Rosaceae, also called peach oil, peach grease, peach tears and peach gum, is sweet and bitter in taste and nontoxic, and is a food material and a traditional Chinese medicine with good health preservation and health care effects. The peach resin extract contains a large amount of polysaccharide, the polysaccharide mainly comprises arabinose and galactose, the expression quantity of an important medium for water exchange between aquaporin and dermis and epidermis can be increased, water channels can be unblocked to become strong hydrodynamic force, the hydration degree of the horny layer reaches a sufficient state, water is quickly supplemented, dry lines and fine lines disappear, and the skin becomes smooth and elastic. The Tibetan peach resin is produced from a Qinghai-Tibet plateau area with the altitude of more than 3100m, belongs to a typical extreme environment area, has strong ultraviolet radiation and low temperature and pressure, belongs to an extreme environment for plant growth, and has higher content of self-repairing and protective active ingredients in peach resin secreted by peach trees in the Tibetan area than in a conventional area.
The barley seed is a cereal crop of the genus barley of the family Gramineae, and the barley is a generic name of the palea-bearing barley and the naked barley. The barley is rich in nutrition, minerals and vitamins, and has certain medicinal value, especially semen Avenae Nudae. The Tibetan highland barley is the main grain of Tibetan people, is a typical plateau environment crop, has the characteristics of high protein, high fiber, high vitamin, low fat, low sugar and the like although the main components are similar to other grains, contains phenolic compounds such as ferulic acid, isoferulic acid, vanillic acid and the like, and active components such as beta-glucan, GABA (gamma-aminobutyric acid) and the like, and is a good product in cereal crops. Barley is used in the fields of food, wine brewing, feed, medicine, functional products, etc., and barley and its related substances can also be used as cosmetic raw materials, such as barley flour, barley seed fine powder, barley seed extract, barley malt extract, barley juice, etc.
The poria cocos is an edible and medicinal fungus, is a fungus plant parasitic on pine roots, is one of the traditional Chinese medicines 'four monarch and eight delicacies', has the effects of inducing diuresis and excreting dampness, and invigorating spleen and calming heart, and is further proved by modern medical research to have multiple effects of resisting tumors, inducing diuresis and reducing edema, enhancing immunity, calming and soothing nerves, inhibiting bacteria and the like. The main active ingredients of the tuckahoe comprise pachyman, triterpenes, protein, fat, inorganic salt and the like, wherein the pachyman and the triterpenes are the main active ingredients, and the active ingredients contained in Tibetan tuckahoe in the Tibetan region are much higher than similar materials in the common region. The components of pachyman, triterpene, etc. and the pharmacological action and biological activity thereof are researched more at home and abroad, and great progress is made.
The solvent comprises water and/or a polyol;
the invention also provides a cosmetic, which comprises the composition with the functions of brightening, firming and resisting wrinkles, wherein the composition accounts for 0.5-30% of the weight of the cosmetic;
further, the composition accounts for 5-20% of the weight of the cosmetic;
the cosmetic is available in the form of solution, jelly, lotion, cream, etc.
The invention has the following beneficial effects:
the composition with the functions of brightening, compacting and resisting wrinkles utilizes the composing principle of monarch, minister, assistant and messenger, all components are mutually blended and synergized, and the purposes of brightening, compacting and resisting wrinkles are achieved in the aspects of controlling oil, recovering the natural moisture content of skin, stimulating the synthesis of mucopolysaccharide, stimulating the synthesis of collagen, accelerating the renewal of epidermal cells, supplementing skin nutritional components and the like;
the composition disclosed by the invention is applied to preparation of cosmetics with brightening, firming and anti-wrinkle functions, the ductility, silky feeling and powdery feeling of the cosmetics are improved, a layer of velvet-like net is formed on skin together with common raw materials of the cosmetics, such as grease, polyhydric alcohol, a thickening agent and the like, and the composition has the advantages of elegant after-skin feeling, safety, high efficiency, mildness, multiple effects and high cost performance.
Drawings
FIG. 1 is a comparative representative view of facial wrinkles of a subject.
Detailed Description
The present invention is described in further detail in the following description of specific embodiments and the accompanying drawings, it is to be understood that these embodiments are merely illustrative of the present invention and are not intended to limit the scope of the invention, which is defined by the appended claims, and modifications thereof by those skilled in the art after reading this disclosure that are equivalent to the above described embodiments.
All the raw materials and reagents of the invention are conventional market raw materials and reagents unless otherwise specified.
Example 1
Composition A with brightening, tightening and anti-wrinkle functions
8% of tequila leaf extract (the sugar base of multi-branched tequila inulin is 6-29), 8% of undaria pinnatifida extract, 8% of peach resin extract, 8% of barley extract, 8% of poria cocos sclerotium extract, 30% of butanediol and 30% of water;
the preparation of the peach resin extract comprises the following steps: soaking resin secreted from peach bark in 60 wt% sodium citrate solution at 55 deg.C for softening, performing ultrasonic microwave treatment at ultrasonic frequency of 45kHz and power of 85W for 12min for 2 times, filtering to remove water, mixing the resin with 9% NaOH and 65% ethanol, performing ultrasonic microwave operation under the same conditions, standing in refrigerator for 24 hr, filtering to obtain precipitate, dissolving with water to obtain supernatant, freezing, and drying to obtain peach resin extract;
The solid-to-liquid ratio of the resin to the sodium citrate solution is 1: 2 mg/mL;
and the mixed solid-liquid ratio of the filtered resin to NaOH and ethanol is 1: 1: 2 mg/mL.
Example 2
Composition B with brightening, tightening and anti-wrinkle functions
10% of Taikui agave leaf extract (the sugar base number of multi-branched agave inulin is 6-29), 8% of undaria pinnatifida extract, 6% of peach resin extract, 10% of barley extract, 6% of poria cocos sclerotium extract, 25% of butanediol and 35% of water;
the preparation of the peach resin extract comprises the following steps: soaking resin secreted from peach bark in 50 wt% sodium citrate solution at 50 deg.C for softening, performing ultrasonic microwave treatment at ultrasonic frequency of 40kHz and power of 80W for 10min for 2 times, filtering to remove water, mixing resin with 8% NaOH and 60% ethanol, performing ultrasonic microwave operation under the same conditions, standing in refrigerator for 24 hr, filtering to obtain precipitate, dissolving with water to obtain supernatant, freezing, and drying to obtain peach resin extract;
the solid-liquid ratio of the resin to the sodium citrate solution is 1: 1 mg/mL;
the mixed solid-liquid ratio of the filtered resin to NaOH and ethanol is 1: 1: 2 mg/mL.
Example 3
Composition C with brightening, tightening and anti-wrinkle functions
3% of Taikui agave leaf extract (the sugar base number of multi-branched agave inulin is 6-29), 10% of undaria pinnatifida extract, 3% of peach resin extract, 4% of barley extract, 10% of poria cocos sclerotium extract, 35% of butanediol and 35% of water;
the preparation of the peach resin extract comprises the following steps: soaking resin secreted from peach bark in 70 wt% sodium citrate solution at 60 deg.C for softening, performing ultrasonic microwave treatment at ultrasonic frequency of 50kHz and power of 90W for 15min for 1 time, filtering to remove water, mixing resin with 10% NaOH and 70% ethanol, performing ultrasonic microwave operation under the same conditions, standing in refrigerator for 24 hr, taking out the precipitate, dissolving with water to obtain supernatant, freezing, and drying to obtain peach resin extract;
the solid-liquid ratio of the resin to the sodium citrate solution is 1: 1 mg/mL;
the mixed solid-liquid ratio of the filtered resin to NaOH and ethanol is 1: 2: 2 mg/mL.
Example 4
Skin care essence with brightening, tightening and anti-wrinkle functions
TABLE 1 skin care essence
Preparing skin care essence: according to the formula, the component of the phase A is dissolved and mixed uniformly at the temperature of 80 ℃, the temperature is reduced to below 45 ℃, the phase B and the phase C are added and stirred for 5 minutes, and the temperature is reduced to normal temperature, so that the skin care essence with the functions of brightening, firming and resisting wrinkles is obtained.
Example 5
Skin cream A with brightening, tightening and anti-wrinkle functions
TABLE 1 skin cream
Preparing skin cream: according to the formula, the components of the phase A are dissolved and mixed uniformly at 75 ℃, the phase B is dissolved and mixed uniformly at 80 ℃, the phase A is added into the phase B during emulsification, the phase B is homogenized for 5 minutes, and the phase C and the phase D are added when the temperature is reduced to be below 45 ℃, so that the skin cream with the functions of brightening, firming and anti-wrinkle is obtained.
Comparative example 1
Composition D
The adopted Taikui agave leaf extract is multi-branched agave inulin, and the sugar base number is 35-55;
the rest is the same as in example 1.
Comparative example 2
Composition E
The same procedure as in example 1 was repeated except that chicory extract (with a sugar content of chicory inulin of 6-29) was used instead of the TAIKOU YINGYANYE extract of example 1.
Comparative example 3
Composition F
The same as in example 1 was repeated except that the extract of Undaria pinnatifida of example 1 was replaced with the extract of Hizikia fusiforme.
Comparative example 4
Composition G
The extract of peach resin, barley and poria cocos sclerotium were not contained, and the rest was the same as in example 1, and water was added to make up to 54%.
Comparative example 5
Composition H
The same as in example 1 except that the undaria pinnatifida extract was not contained, and water was supplemented to 38%.
Comparative example 6
Composition I
The extract of agave leaves was not too deficient, the rest was the same as in example 1, and water was added to make up to 38%.
Comparative example 7
Skin cream B
Composition D of comparative example 1 was used in place of composition A of example 5, and the remaining components and preparation method were the same as in example 5.
Comparative example 8
Skin cream C
Composition E of comparative example 2 was used in place of composition a of example 5, and the remaining components and preparation method were the same as in example 5.
Comparative example 9
Skin cream D
Composition F of comparative example 3 was used in place of composition a of example 5, and the remaining components and preparation method were the same as in example 5.
Comparative example 10
Skin cream E
Composition G of comparative example 4 was used instead of composition a of example 5, and the remaining components and preparation method were the same as example 5.
Comparative example 11
Skin cream F
Composition H of comparative example 5 was used in place of composition a of example 5, and the remaining components and preparation method were the same as example 5.
Comparative example 12
Skin cream G
Composition I of comparative example 6 was used in place of composition A of example 5, and the remaining components and preparation method were the same as those of example 5.
Test example 1
And (3) safety evaluation: human skin occlusion patch test
The compositions of example 1, example 2, example 3, comparative example 4, comparative example 5 and comparative example 6 were tested according to the closed patch test requirements in the 2015 edition of technical Specification for cosmetic safety; the negative control was a blank control, and the subjects were 30 persons in total, with a mean age of 35 ± 10 years.
The test results are as follows:
TABLE 3 closed patch test on human skin
As can be seen from Table 3, no positive reaction occurred in examples 1 to 3 and comparative examples 4 to 6; the blank control showed a suspicious reaction, and it can be determined that none of example 1, example 2, example 3, comparative example 4, comparative example 5, and comparative example 6 caused adverse reactions to the skin of the subjects of the batch.
Test example 2
Evaluation of human body lightening efficacy
The test method comprises the following steps: 7 samples such as skin creams prepared in example 5, comparative example 7, comparative example 8, comparative example 9, comparative example 10, comparative example 11 and comparative example 12 were used as test samples, and a skin cream containing no composition having functions of brightening, firming and anti-wrinkle and having the same other components was used as a placebo. Double-blind, open, randomized, self-cross-control observation studies were used. 140 eligible subjects (63 men and 77 women, between the ages of 25 and 45) were screened and randomized into 7 groups of 20 individuals, each group tested one sample. Each group of subjects applied test samples to one side of the face on a random basis and placebo to the other side for 28 days, twice a day, once in the morning and once in the evening. Face-related tests were performed on days 0, 14, and 28 to evaluate the lightening efficacy of the product. The subjects did not experience erythema, pimples, wheal, itching, and other adverse skin reactions associated with the products tested during the trial.
Test indexes and main instruments: respectively measuring the skin brightness ITA of the face designated parts of the subject by using a skin color probe of a skin analyzer0And detecting, recording and calculating the value.
Evaluation criteria: skin lightness ITA0The higher theThe brighter the skin, the whiter the skin.
TABLE 4 human body brightening efficacy experiment
As can be seen from the data in Table 4, on days 14 and 28, the face-side indices of the subjects using the test samples of example 5, comparative example 7, comparative example 8, comparative example 9, comparative example 10, comparative example 11 and comparative example 12 exhibited a tendency of ITA, as compared with the placebo side0Increased values (positive improvement rate) manifested as a whitening of the skin tone on the subject's skin; wherein the subject uses the ITA of example 50The improvement rate of the value is obviously higher than that of comparative example 7, comparative example 8, comparative example 9, comparative example 10, comparative example 11 and comparative example 12; and at day 14 the skin color of the subject was significantly improved. The result shows that the skin cream prepared in example 5 has the functions of brightening, firming and resisting wrinkles, and has the effects of brightening and whitening the skin color of the face.
Test example 3
Evaluation of human body tightening and anti-wrinkle efficacy
The test method comprises the following steps: the test indexes of each group of subjects were recorded in the same manner as in test example 2.
Test indexes and main instruments: detecting, recording and calculating the elastic change of the designated parts (forehead, canthus, under-eye and normal line) of the face of the subject by using an elastic probe of a skin analyzer; the pictures were analyzed for wrinkle macrochanges using the VISIA facial photography system.
Evaluation criteria: the higher the elasticity improvement rate is, the more remarkable the VISIA image wrinkle macroscopic improvement is, and the better the product is in firming and anti-wrinkle effects are.
1) In improving skin elasticity:
TABLE 5 human firming and anti-wrinkle efficacy-28 days skin elasticity test results
On day 14, there was no statistical significance, no significant difference in the ratio of elasticity improvement in both facial areas of the subjects. As can be seen from the data in table 5, on day 28, the skin elasticity was improved on the test side of example 5, comparative example 7, comparative example 8, comparative example 9, comparative example 10, comparative example 11, comparative example 12, compared to the placebo side; wherein, the skin elasticity improvement rate of the subjects using the forehead, the canthus, the under-eye and the grain of the law of the example 5 is obviously higher than that of the subjects of the comparative examples 7, 8, 9, 10, 11 and 12; and the skin elasticity improvement rate is highest under the eyes for each group of test samples. The result shows that the skin cream A prepared in the example 5 can obviously improve the skin elasticity, has the effects of tightening and resisting wrinkles, and has the most obvious performance under eyes.
2) Macroscopic evaluation of VISIA images wrinkles:
from the wrinkle area macro image data, it was shown that the subjects had improved the wrinkles at the forehead, canthus, under the eyes, and normal line side on day 28 using example 5, comparative example 7, comparative example 8, comparative example 9, comparative example 10, comparative example 11, and comparative example 12, and the improvement was greater than on the placebo side. Among them, the test sample of example 5 was used by a subject to improve the wrinkles under the eyes most significantly, and the result of the skin elasticity test was substantially the same as that of the test sample of example 5, and a typical graph is shown in fig. 1, in which a subject used the test sample of example 5 to macroscopically improve and compare D0 (left) and D28 (right) wrinkles on one facial area, and wrinkles on the forehead, canthus, under the eyes, and at the position of a normal line after D28 were reduced, so that it was found that the skin cream having the functions of brightening, tightening, and anti-wrinkle, prepared in example 5, had the effects of tightening and anti-wrinkle on the skin.
Claims (10)
1. A composition with functions of brightening, firming and resisting wrinkles, which is characterized by comprising the following components: folium agaves Sisalanae extract, thallus laminariae extract, peach resin extract, fructus Hordei vulgaris extract and Poria sclerotium extract.
2. The composition with brightening, tightening and anti-wrinkle functions as claimed in claim 1, wherein the composition comprises 1-10% by mass of the extract of agave americana, 1-10% by mass of the extract of undaria pinnatifida, 1-10% by mass of the extract of peach resin, 1-10% by mass of the extract of barley, 1-10% by mass of the extract of sclerotium of poria cocos, and the balance of a solvent.
3. The composition with brightening, tightening and anti-wrinkle functions as claimed in claim 1, wherein the too deficient agave extract is multi-branched agave inulin, and the sugar base number is 6-29.
4. The composition with brightening, tightening and anti-wrinkle functions as claimed in claim 1, wherein the peach resin extract is prepared by: soaking resin secreted from peach tree bark in 50-70 wt% sodium citrate solution at 50-60 ℃ for softening, then carrying out ultrasonic microwave treatment with the ultrasonic frequency of 40-50 kHz and the power of 80-90W for 10-15 min for 1-2 times, filtering to remove water, mixing the resin with NaOH with the concentration of 8-10% and ethanol with the concentration of 60-70%, carrying out ultrasonic microwave operation under the same conditions again, placing in a refrigerator for 24 hours, taking out and filtering to obtain a precipitate, dissolving with water to obtain a supernatant, freezing, and drying to obtain the peach tree resin extract.
5. The composition with brightening, tightening and anti-wrinkle functions as claimed in claim 4, wherein the solid-to-liquid ratio of the resin to the sodium citrate solution is 1: (1-2) mg/mL.
6. The composition with the functions of brightening, firming and anti-wrinkle as claimed in claim 4, wherein the mixed solid-liquid ratio of the resin after filtration to NaOH and ethanol is 1:
(1～2)：(1～2)mg/mL。
7. The composition with brightening, tightening and anti-wrinkle functions as claimed in claim 2, wherein the solvent comprises water and/or a polyol.
8. Use of the composition with brightening, firming and anti-wrinkle functions as defined in any one of claims 1-7 in cosmetics.
9. The composition for cosmetic use according to claim 8, wherein the composition with the functions of brightening, firming and anti-wrinkle accounts for 0.5-30% of the weight of the cosmetic.
The cosmetic is available in the form of solution, jelly, lotion, cream, etc.
10. The cosmetic composition of claim 9, wherein the composition is used in a cosmetic application, and the composition accounts for 5-20% of the weight of the cosmetic composition.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202210122777.XA CN114557938B (en) | 2022-02-09 | 2022-02-09 | Composition with brightening, tightening and anti-wrinkle functions and preparation method and application thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202210122777.XA CN114557938B (en) | 2022-02-09 | 2022-02-09 | Composition with brightening, tightening and anti-wrinkle functions and preparation method and application thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN114557938A true CN114557938A (en) | 2022-05-31 |
| CN114557938B CN114557938B (en) | 2024-03-26 |
Family
ID=81714776
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202210122777.XA Active CN114557938B (en) | 2022-02-09 | 2022-02-09 | Composition with brightening, tightening and anti-wrinkle functions and preparation method and application thereof |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN114557938B (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN116747158A (en) * | 2023-08-01 | 2023-09-15 | 广州市花木草生物科技有限公司 | Cosmetic composition capable of resisting wrinkle and compacting through mitochondria and application thereof |
Citations (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108324674A (en) * | 2018-03-26 | 2018-07-27 | 广东巴松那生物科技有限公司 | A kind of creme of cosmetic complex and preparation method thereof containing actin |
| CN108451860A (en) * | 2018-06-17 | 2018-08-28 | 佛山文森特知识产权服务有限公司 | Dispel skin care compositions and its application of small microgroove |
| CN108853000A (en) * | 2018-08-17 | 2018-11-23 | 广州皓雨投资有限公司 | Have effects that moisture-keeping crease-shedding restores the composition of elasticity of skin, facial mask and preparation method thereof |
| CN112022751A (en) * | 2020-10-12 | 2020-12-04 | 惠州市好好爱日化用品有限公司 | Tightening lifting mask |
| CN113274305A (en) * | 2021-06-23 | 2021-08-20 | 植物医生(广东)生物科技有限公司 | Instant firming wrinkle-removing whitening mask liquid and preparation method and application thereof |
| CN113712859A (en) * | 2021-08-09 | 2021-11-30 | 科丝美诗(中国)化妆品有限公司 | Soothing and repairing composition and preparation method and application thereof |
| US20220016196A1 (en) * | 2020-07-09 | 2022-01-20 | Unigen, Inc. | Aloe Based Compositions Comprising Polysaccharides and Polyphenols for Regulation of Homeostasis of Immunity |
-
2022
- 2022-02-09 CN CN202210122777.XA patent/CN114557938B/en active Active
Patent Citations (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108324674A (en) * | 2018-03-26 | 2018-07-27 | 广东巴松那生物科技有限公司 | A kind of creme of cosmetic complex and preparation method thereof containing actin |
| CN108451860A (en) * | 2018-06-17 | 2018-08-28 | 佛山文森特知识产权服务有限公司 | Dispel skin care compositions and its application of small microgroove |
| CN108853000A (en) * | 2018-08-17 | 2018-11-23 | 广州皓雨投资有限公司 | Have effects that moisture-keeping crease-shedding restores the composition of elasticity of skin, facial mask and preparation method thereof |
| US20220016196A1 (en) * | 2020-07-09 | 2022-01-20 | Unigen, Inc. | Aloe Based Compositions Comprising Polysaccharides and Polyphenols for Regulation of Homeostasis of Immunity |
| CN112022751A (en) * | 2020-10-12 | 2020-12-04 | 惠州市好好爱日化用品有限公司 | Tightening lifting mask |
| CN113274305A (en) * | 2021-06-23 | 2021-08-20 | 植物医生(广东)生物科技有限公司 | Instant firming wrinkle-removing whitening mask liquid and preparation method and application thereof |
| CN113712859A (en) * | 2021-08-09 | 2021-11-30 | 科丝美诗(中国)化妆品有限公司 | Soothing and repairing composition and preparation method and application thereof |
Non-Patent Citations (1)
| Title |
|---|
| 李向东等: ""超声微波协同萃取桃胶多糖的工艺研究"", 《中国食品添加剂》, pages 77 - 82 * |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN116747158A (en) * | 2023-08-01 | 2023-09-15 | 广州市花木草生物科技有限公司 | Cosmetic composition capable of resisting wrinkle and compacting through mitochondria and application thereof |
| CN116747158B (en) * | 2023-08-01 | 2024-01-23 | 广州市花木草生物科技有限公司 | Cosmetic composition capable of resisting wrinkle and compacting through mitochondria and application thereof |
Also Published As
| Publication number | Publication date |
|---|---|
| CN114557938B (en) | 2024-03-26 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN102406581B (en) | Skin protecting composite with function of tightening skin | |
| CN110464693A (en) | Composition for splitting yeast tunning lysis object containing two and preparation method thereof and the application in cosmetics | |
| KR101373636B1 (en) | Composition for improving condition of skin and scalp containing fermented extracts of herb mixture | |
| CN103284940A (en) | Saccharomycetes fermented traditional Chinese medicine composition, as well as preparation method and application thereof | |
| CN108143702A (en) | A kind of efficient whitening and moisturizing facial mask liquid, facial mask and preparation method thereof | |
| KR101096393B1 (en) | Cosmetic Composition for Skin Moisturizing | |
| CN108271982A (en) | A kind of Isin glue collagen peptide vegetable solid beverage and the preparation method and application thereof | |
| CN102579315B (en) | Plant composition applied to cosmetics and application method for plant composition | |
| CN108836919B (en) | Moisturizing cosmetic composition and preparation method and application thereof | |
| CN107334726A (en) | A kind of acne-removing composition and its preparation method and application | |
| CN110037981A (en) | A kind of skin care item and the preparation method and application thereof | |
| CN111265441A (en) | Composition capable of enhancing skin night repair and regeneration capacity and application thereof | |
| CN108670933B (en) | Skin care composition with moisturizing, whitening and anti-aging functions and application thereof | |
| CN114557938B (en) | Composition with brightening, tightening and anti-wrinkle functions and preparation method and application thereof | |
| KR101985381B1 (en) | Cosmetic composition for exfoliating skin keratin comprising fruit fermentation complex made by fermenting grape, orange, apple, lemon and lime | |
| CN113143820A (en) | Anti-aging composition and preparation method thereof | |
| CN111713699A (en) | Bird's nest weight-reducing composition, functional food thereof, preparation method and application | |
| KR101880470B1 (en) | Cosmetic composition comprising organic acid fermentation and natural polymer for moisturizing effect on the skin | |
| CN114652666A (en) | Application preparation of nourishing and nourishing intelligence-improving components in skin care and care products | |
| CN1111106A (en) | Beauty food | |
| CN107281084A (en) | A kind of whitening Chinese medicament mask and preparation method thereof | |
| CN113876671A (en) | Anti-aging composition containing rape bud extract and preparation method thereof | |
| CN110585107A (en) | Wonderful age essence capable of firming skin, moistening skin, beautifying skin and deeply replenishing water and preparation method thereof | |
| CN105410555A (en) | Grapefruit enzyme nutrient solution and preparation method thereof | |
| CN110679939A (en) | A food composition with skin caring, whitening, skin moistening and speckle removing effects |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| GR01 | Patent grant | ||
| GR01 | Patent grant |