CN107334726A - A kind of acne-removing composition and its preparation method and application - Google Patents
A kind of acne-removing composition and its preparation method and application Download PDFInfo
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- CN107334726A CN107334726A CN201710773759.7A CN201710773759A CN107334726A CN 107334726 A CN107334726 A CN 107334726A CN 201710773759 A CN201710773759 A CN 201710773759A CN 107334726 A CN107334726 A CN 107334726A
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- acne
- tunning
- removing composition
- rice bran
- fermented soybean
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/99—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from microorganisms other than algae or fungi, e.g. protozoa or bacteria
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/59—Mixtures
- A61K2800/592—Mixtures of compounds complementing their respective functions
- A61K2800/5922—At least two compounds being classified in the same subclass of A61K8/18
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/70—Biological properties of the composition as a whole
- A61K2800/72—Hypo-allergenic
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/80—Process related aspects concerning the preparation of the cosmetic composition or the storage or application thereof
- A61K2800/85—Products or compounds obtained by fermentation, e.g. yoghurt, beer, wine
Abstract
The present invention provides a kind of acne-removing composition and its preparation method and application.In terms of the percentage by weight of the gross weight of the acne-removing composition, the acne-removing composition includes following components：Radish root tunning filtrate：10~50%；Fermented soybean product extract：10~50%；Chlorella tunning：15~35%；Rice bran tunning：5~25%.Acne-removing composition provided by the invention, according to the compounding of four kinds of tunnings of the present invention, the synergy of plant fermentation product can be effectively played, more effectively plays bioactivity.The acne-removing composition of the present invention has good anti-acne effect, while has the performance non-stimulated to skin safe.
Description
Technical field
The present invention relates to a kind of acne-removing composition and its preparation method and application, and in particular to one kind is by plant fermentation product
The acne-removing composition formed is compounded, belongs to cosmetic field.
Background technology
Acne (being commonly called as whelk) is the chronic inflammatory skin problem of puberty common pilosebaceous follicle, is mainly in
Face, the back of the body, chest etc. are containing the more position of sebaceous glands；Its origin cause of formation mainly has hypersteatosis, sebaceous glands follicular hyperkeratosis, Cuo
Sore Propionibacterium amount reproduction, the reaction of perifollicolar inflammation etc..
Seek safe and effective acne-removing composition and have been carried out many years, also disclose that some anti-acne groups in the prior art
The composition of compound.As patent CN105796424A discloses a kind of acne-removing composition, the acne-removing composition contains vitamin A palm fibre
Glycerin monostearate active matter, azelaic acid active matter, salicylic acid active matter, Gotu Kola P.E；Wherein described Retinol Palmitate
Active matter, azelaic acid active matter and salicylic acid active matter are respectively using beta-schardinger dextrin parcel Retinol Palmitate, azelaic acid
With salicylic acid made from active matter.The acne-removing composition has excellent anti-acne effect.But from such as salicylic acid, azelaic acid
Reach etc. chemical composition and reduce propionibacterium acnes, dredge pore, hair follicle keratinization is peeled off normal and then good anti-acne
While effect, certain excitant is often carried out to skin tape.
Patent CN105012479A discloses a kind of acne-removing composition, the acne-removing composition include Butyrospermum parkii fruit fat,
Phellodendron extract, black extract of willow bark, purslane extract, extractive of perilla, Gotu Kola P.E and Semen phaseoli radiati extract, energy
Effectively nurse one's health small pox flesh and suppress small pox regeneration.But as anti-acne composition, often cost is higher from above-mentioned plant extracts
And it is more slow to work.
The content of the invention
Problems to be solved by the invention
It is an object of the invention to provide a kind of acne-removing composition and its preparation method and application.The acne-removing composition by
Plant fermentation product compounding forms.By society's acne composition of the present invention apply alleviation in skin care item or cosmetics to acne and
Dispel with good result, while there is good cutaneous safety, stimulation will not be produced to skin.
The solution used to solve the problem
The present invention provides a kind of acne-removing composition, in terms of the percentage by weight of the gross weight of the acne-removing composition, including
Following components：
Radish root tunning filtrate：10~50%；
Fermented soybean product extract：10~50%；
Chlorella tunning：15~35%；
Rice bran tunning：5~25%.
According to the acne-removing composition of the present invention, in terms of the percentage by weight of the gross weight of the acne-removing composition, the radish
The addition of root tunning filtrate is 20~40%；The addition of the fermented soybean product extract is 20~40%；Institute
The addition for stating chlorella tunning is 20~30%；The addition of the rice bran tunning is 10~20%.
According to the present invention acne-removing composition, the radish root tunning filtrate, the fermented soybean product extract,
The mass ratio of the chlorella tunning and rice bran tunning is 1~3:1~3:0.8~3:1, preferably 1.5~2.5:
1.2~2.2:1.5~2.5:1.
According to the acne-removing composition of the present invention, the radish root tunning filtrate is bright string coccus/radish root tunning
Filtrate.
According to the acne-removing composition of the present invention, the fermented soybean product extract is bacillus/fermented soybean product
The combination of one or both of extract, Bacillus acidi lactici/fermented soybean product extract.
According to the acne-removing composition of the present invention, the rice bran tunning is saccharomycete/rice bran tunning, gemma bar
The combination of one or both of bacterium/rice bran extract tunning filtrate.
The present invention also provides a kind of preparation method of the acne-removing composition according to the present invention, including the step that each component is mixed
Suddenly.
According to application of the acne-removing composition of the present invention in cosmetics or skin care item.
Application according to the present invention, it is described in terms of the cosmetics or the percentage by weight of the gross weight of the skin care item
The addition of acne-removing composition is 1-15%, preferably 3%-10%.
Application according to the present invention, the cosmetics or the skin care item include water aqua type, gel formulation or emulsion-type.
The effect of invention
(1) acne-removing composition provided by the invention, according to the compounding of four kinds of tunnings of the present invention, can effectively play
The synergy of plant fermentation product, more effectively plays bioactivity.
(2) acne-removing composition of the invention has good anti-acne effect, while has the property non-stimulated to skin safe
Energy.
Embodiment
It will be detailed below various exemplary embodiments, feature and the aspect of the present invention.Special word " example herein
Property " mean " being used as example, embodiment or illustrative ".Any embodiment here as illustrated by " exemplary " should not necessarily be construed as
Preferred or advantageous over other embodiments.
In addition, in order to which the present invention is better described, numerous details is given in embodiment below.
It will be appreciated by those skilled in the art that without some details, the present invention can equally be implemented.In other example,
It is not described in detail for method well known to those skilled in the art, means, equipment and step, in order to highlight the master of the present invention
Purport.
The present invention provides a kind of acne-removing composition, including following components：Radish root tunning filtrate, fermented soybean product
Extract, chlorella tunning and rice bran tunning.
The radish root tunning filtrate of the present invention can be prepared by radish root through strain fermentation.Radish root ferments
Product filtrate application has the function that the bacteriostasis property of wide spectrum and repairs anti-inflammatory in the present invention, can effectively suppress acne lesions
Propionibacterium acnes and MRSE.Radish root tunning filtrate can also subtract in the acne-removing composition of the present invention
The amount reproduction of few propionibacterium acnes.
In the present invention, radish root tunning filtrate is preferably bright string coccus/radish root tunning filtrate.Bright string ball
Bacterium/radish root tunning filtrate is that bright string coccus is a kind of lactic acid bacteria, and it is secreted through Leuconostoc fermentation gained by radish root
Antibacterial peptide antibacterial range it is wide, safe.Bright string coccus/radish root tunning filtrate can be anti-acne group in the present invention
Compound provides the bacteriostasis efficacy of natural safety, can suppress mould, bacterium, saccharomycete, Escherichia coli, staphylococcus aureus,
A variety of mushrooms such as ETEC (E.coli), Aspergillus (A.niger).
According to the acne-removing composition of the present invention, in terms of the percentage by weight of the gross weight of the acne-removing composition, the radish
The addition of root tunning filtrate is 10~50%, preferably 20~40%, more preferably 30%.When radish root tunning
For the addition of filtrate when in the range of 10~50%, it can provide excellent bacteriostasis property.When radish root tunning filtrate
When addition is less than 10%, excellent bacteriostasis property can not be obtained；When the addition of radish root tunning filtrate is more than 50%
When, unnecessary radish root tunning filtrate can not also play the effect of more preferable.
Fermented soybean product extract is the day extracted in the metabolin generated by soybean after specific strain fermentation
Right composition.In the present invention, it has the good function of reducing fat secretion, recover skin normal keratinization process.Specifically
Ground, the fermented soybean product extract are bacillus/fermented soybean product extract, Bacillus acidi lactici/fermented soybean product
One or both of extract combines.Fermented soybean product extract in the present invention is preferably bacillus/fermented soybean
Product extract.
It is described big in terms of the percentage by weight of the gross weight of the acne-removing composition according to the acne-removing composition of the present invention
The addition of beans tunning extract is 10~50%, preferably 20~40%, more preferably 30%.When fermented soybean product
At 10~50%, it can be compounded the addition of extract with other three kinds of compositions, so as to play synergy, reach excellent
Oil-control and anti-acne effect.When the addition of fermented soybean product extract is less than 10%, synergy can not be played, oil-control with
Anti-acne effect unobvious；When the addition of fermented soybean product extract is more than 50%, the extraction of unnecessary fermented soybean product
Thing can not play the effect of more preferable.
Chlorella (Chlorella) is green alga rich in protein, amino acid and diversified vitamin and mineral matter
The door general natural disposition monoplast green alga of Chlorella, is a kind of spherical unicellular fresh water algae, 3~8 microns of diameter, than red blood in human body
Ball is smaller.In the present invention, chlorella tunning, which has, improves skin barrier, helps to pin more juicy, be anti-irritant, careful
The effect of skin pore, while the antioxidation of chlorella tunning is also superior to conventional chlorella extract.
It is described small in terms of the percentage by weight of the gross weight of the acne-removing composition according to the acne-removing composition of the present invention
The addition of ball algae tunning is 15~35%, preferably 20~30%, more preferably 25%.When chlorella tunning
Addition is at 15~35%, using the teaching of the invention it is possible to provide excellent skin moisturizing, recovers skin water and oil balance and the function of careful pore.When
When the addition of chlorella tunning is less than 15%, skin moisturizing, recover the effect of skin water and oil balance and careful pore not
Substantially；When the addition of chlorella tunning is higher than 35%, the content of other components can decrease, so as to influence anti-acne
Effect.
The rice bran tunning of the present invention, such as：It can be by the distiller's yeast that is saccharified, and be obtained using strain fermentation.This
One special process causes rice bran tunning to have high active content (6% protein, asafoetide relative to other rice extracts
Acid) and the characteristics of no cytotoxicity.In the present invention, rice bran tunning reaches whitening flesh by suppressing the activity of TYR enzyme
The function of skin, help to remove the acne print left after anti-acne.
B16 cell be by α-MSH and inflammatory mediator (such as histamine and prostaglandin E2) activation, increase ring AMP it is horizontal and
Trigger activated tyrosine enzyme and then form the chain reaction of melanin.It is main tyrosinase transcription factor, by α-MSH
(or histamine, prostaglandin E2) activation triggers unidirectional response.
In the present invention, rice bran tunning is suppressed by reducing the activity of MITF (microphthalmia collaboration transcription factor)
Tyrosinase activity；Completely melanin can be blocked to be formed, inhibition is good；Compared to other rice class raw material acellular poisons
Property.The rice bran tunning is in saccharomycete/rice bran tunning, bacillus/rice bran extract tunning filtrate
One or two combination.
According to the acne-removing composition of the present invention, in terms of the percentage by weight of the gross weight of the acne-removing composition, the rice
The addition of chaff tunning is 5~25%, preferably 10~20%, more preferably 15%.When the addition of rice bran tunning
Amount advantageously reduces MITF activity, so as to suppress tyrosinase activity, inhibition is good when between 5~25%.Work as rice bran
When the addition of tunning is less than 5%, inhibition is poor；When the addition of rice bran tunning is higher than 25%, it is impossible to
Inhibition is further improved, and cost is higher.
According to the present invention acne-removing composition, the radish root tunning filtrate, the fermented soybean product extract,
The mass ratio of the chlorella tunning and rice bran tunning is 1~3:1~3:0.8~3:1, preferably 1.5~2.5:
1.2~2.2:1.5~2.5:1.When radish root tunning filtrate, fermented soybean product extract, chlorella tunning and rice
The mass ratio of chaff tunning is 1~3:1~3:0.8~3:When between 1, four kinds of tunning extracts energy after compounding
Reach preferably synergy and acne-removing.
Pass through radish root tunning filtrate, fermented soybean product extract, chlorella tunning and the rice bran of the present invention
The compounding of tunning, so as to obtain a kind of acne-removing composition with good acne-removal function, also have stingless to skin safe
Sharp performance.
The present invention also provides a kind of preparation method of the acne-removing composition according to the present invention, including the step that each component is mixed
Suddenly.
Acne-removing composition of the present invention is by the way that the radish root tunning filtrate, the fermented soybean product are carried
Take thing, the chlorella tunning and the rice bran tunning to sequentially add with container, fully stir at ambient temperature
Mix well mixed consistent acquisition.In the present invention, " room temperature condition " generally refers to temperature between 20-30 DEG C, preferably at 22-28 DEG C
Between.
The acne-removing composition of the present invention can be applied in cosmetics or skin care item.With the cosmetics or the weight of skin care item
Percentages are measured, the addition of the acne-removing composition is 1-15%, preferably 3%-10%, and the addition of acne-removing composition exists
When in the range of 1-15%, excellent anti-acne effect can reach.When the addition of acne-removing composition is less than 1%, it is impossible to obtain good
Good anti-acne using effect, when the addition of acne-removing composition is higher than 15%, anti-acne effect is without rising appreciably and cost also phase
It should improve.
According to application of the acne-removing composition of the present invention in cosmetics or skin care item, the cosmetics or skin care item include
Water aqua type, gel formulation or emulsion-type.
The water aqua type skin care item include：Maintenance water, moisture retention water, toner or facial mask etc.；The gel formulation skin care item
Including facial treatment essence, skin care gel, gel shape sleep mask etc., emulsion-type skin care item include moisturizing lotion, moisturizing cream etc..
The water aqua type cosmetics include：Toner etc.；The emulsion-type cosmetics include：Sunscreen or isolation are newborn, anti-
Shine frost, BB frosts or sun screen etc..
Embodiment
Embodiment of the present invention is described in detail below in conjunction with embodiment, but those skilled in the art will
Understand, the following example is merely to illustrate the present invention, and should not be taken as limiting the scope of the invention.It is unreceipted specific in embodiment
Condition person, the condition suggested according to normal condition or manufacturer are carried out.Agents useful for same or the unreceipted production firm person of instrument, it is
The conventional products for meeting certain mass standard of acquisition purchased in market can be passed through.
Embodiment 1
Take bright string coccus/parts by weight of radish root tunning filtrate 20, the bacillus/weight of fermented soybean product extract 40
Measure part, the parts by weight of chlorella tunning 25, the saccharomycete/parts by weight of rice bran tunning 15.Wherein, bright string coccus/radish root hair
Ferment Product filtrate, bacillus/fermented soybean product extract, chlorella tunning and saccharomycete/rice bran tunning
Mass ratio is 4/3:8/3:5/3:1.After being well mixed under room temperature condition, acne-removing composition I is prepared.
Embodiment 2
Take bright string coccus/parts by weight of radish root tunning filtrate 30, the bacillus/weight of fermented soybean product extract 30
Measure part, the parts by weight of chlorella tunning 25, the saccharomycete/parts by weight of rice bran tunning 15.Wherein, bright string coccus/radish root hair
Ferment Product filtrate, bacillus/fermented soybean product extract, chlorella tunning and saccharomycete/rice bran tunning
Mass ratio is 2:2:5/3:1.After being well mixed under room temperature condition, acne-removing composition II is prepared.
Embodiment 3
Take bright string coccus/parts by weight of radish root tunning filtrate 50, the bacillus/weight of fermented soybean product extract 20
Measure part, the parts by weight of chlorella tunning 20, the saccharomycete/parts by weight of rice bran tunning 10.Wherein, bright string coccus/radish root hair
Ferment Product filtrate, bacillus/fermented soybean product extract, chlorella tunning and saccharomycete/rice bran tunning
Mass ratio is 5:2:2:1.After being well mixed under room temperature condition, acne-removing composition III is prepared.
Embodiment 4
Take bright string coccus/parts by weight of radish root tunning filtrate 25, the bacillus/weight of fermented soybean product extract 25
Measure part, the parts by weight of chlorella tunning 35, the saccharomycete/parts by weight of rice bran tunning 15.Bright string coccus/radish root fermentation production
Thing filtrate, bacillus/fermented soybean product extract, the quality of chlorella tunning and saccharomycete/rice bran tunning
Than for 5/3:5/3:7/3:1.After being well mixed under room temperature condition, acne-removing composition IV is prepared.
Comparative example 1
Take bacillus/parts by weight of fermented soybean product extract 60, the parts by weight of chlorella tunning 25, saccharomycete/
The parts by weight of rice bran tunning 15.Bacillus/fermented soybean product extract, chlorella tunning and saccharomycete/rice bran
The mass ratio of tunning is 4:5/3:1.After being well mixed under room temperature condition, acne-removing composition V is prepared.
Comparative example 2
Take bright string coccus/parts by weight of radish root tunning filtrate 60, the parts by weight of chlorella tunning 25, saccharomycete/rice
The parts by weight of chaff tunning 15.Bright string coccus/radish root tunning filtrate, chlorella tunning and saccharomycete/rice bran fermentation
The mass ratio of product is 4:5/3:1.After being well mixed under room temperature condition, acne-removing composition VI is prepared.
Comparative example 3
Take bright string coccus/parts by weight of radish root tunning filtrate 15, the bacillus/weight of fermented soybean product extract 25
Measure part, the parts by weight of chlorella tunning 25, the saccharomycete/parts by weight of rice bran tunning 35.Bright string coccus/radish root fermentation production
Thing filtrate, bacillus/fermented soybean product extract, the quality of chlorella tunning and saccharomycete/rice bran tunning
Than for 3/7:5/7:5/7:1.After being well mixed under room temperature condition, acne-removing composition VII is prepared.
Application Example
Application Example 1-3
Embodiment 1-3 acne-removing composition I-III is added in skin care gel, obtains anti-acne jelly.After test addition
Anti-acne jelly anti-acne performance and safety in utilization.Wherein, the formula of anti-acne jelly is as shown in table 1 below.
The preparation method of anti-acne jelly is：Formed according to the formula of Application Example 1-3 anti-acne jelly in table 1, by A phases
It is heated to 75 DEG C and stirs, high speed homogenization mixes under 2500r/min rotating speed；B phases are added after being cooled to less than 45 DEG C
Stir, anti-acne jelly I-III is prepared.
Application Example 4-6
Embodiment 1-3 acne-removing composition I-III is added in facial treatment milk, obtains anti-acne emulsion.After test addition
Anti-acne emulsion anti-acne performance and safety in utilization.Wherein, the formula of anti-acne emulsion is as shown in table 2 below.
The preparation method of anti-acne emulsion is：Formed according to the formula of Application Example 4-6 anti-acne emulsion in table 2, by A phases
It is heated to 75 DEG C and stirs, high speed homogenization is mixed under 2500r/min rotating speed, and B heat phases to 75 DEG C and are stirred equal
A phases are added after even, high speed homogenization mixes under 2500r/min rotating speed；C phases are added after being cooled to less than 45 DEG C to stir,
Anti-acne emulsion I-III is prepared.
Table 1
Table 2
Comparison study example
Comparison study example 1-3
Comparative example 1-3 acne-removing composition V-VII is added in skin care gel, obtains anti-acne jelly.After test addition
Anti-acne jelly anti-acne performance.Wherein, the formula of skin care gel is as shown in table 3.
Formed according to the formula of the anti-acne emulsion in table 3, using Application Example 1-3 preparation method, be prepared and dispel
Acne gel IV-VI.
Comparison study example 4-6
Comparative example 1-3 acne-removing composition V-VII is added in facial treatment milk, obtains anti-acne emulsion.After test addition
Anti-acne emulsion anti-acne performance.Wherein, the formula of facial treatment milk is as shown in table 4.
Formed according to the formula of the anti-acne emulsion in table 4, using Application Example 4-6 preparation method, be prepared and dispel
Acne emulsion IV-VI.
Table 3
Table 4
Acne-removing is tested
Test method：19-28 year acne skin quality subject of age is selected, uses test sample (application daily sooner or later each 1 time
Embodiment 1-6 and Comparison study example 1-6) 3 days, after 7 days, with Digimic2000 skin measurement systems, acne count is carried out
Quantitative test, calculate acne count and compare the down ratio for using preceding initial value, test data result is as shown in table 5.
Table 5
As can be seen from Table 5, acne-removing test result show, subject use test product (anti-acne jelly I,
II and anti-acne emulsion I, II) 3 days and after 7 days, acne count, which has, largely to be reduced.Subject is using test product
(anti-acne jelly III and anti-acne emulsion III) 3 days and after 7 days, acne count, which also has, largely to be reduced, but using after 7 days
The reduction quantity of acne count is slightly less than anti-acne jelly I, II or anti-acne emulsion I, II.Subject is using test product (anti-acne
Gel IV-VI and anti-acne emulsion IV-VI) after, acne count down ratio is relatively low.
Crowd's investigation on probation
Carry out crowd's investigation on probation respectively to test product.Select 19-28 year acne skin quality subject of age, daily morning and evening
Each 1 use test product anti-acne jelly I-III and anti-acne emulsion I-III 7 days, fill in using effect questionnaire, according to
Following condition statistical result, statistical result are as shown in table 6.
Recovery from illness：Skin lesion is disappeared, or only leaves pigmentation, therapeutic index ＞ 90%；
It is effective：Skin lesion is largely disappeared, therapeutic index 60-90%；
Effectively：Skin lesion partial remission, therapeutic index 20-60%；
It is invalid：Skin lesion regression unobvious, therapeutic index ＜ 20%.
Table 6
As can be seen from Table 6, the result of crowd's investigation on probation show, subject use test product (anti-acne jelly I,
II and anti-acne emulsion I, II) after 7 days, acne lesions situation has different degrees of regression.Subject is using test product
After (anti-acne jelly III and anti-acne emulsion III) 7 days, acne lesions situation also has different degrees of regression.And use test
Product (anti-acne jelly IV-VI and anti-acne emulsion IV-VI) is after 7 days, acne skin lesion situation compared to test product (anti-acne jelly I,
II and anti-acne emulsion I, II) it is poor.
Human safety is examined
According to《Cosmetics safety technical specification》2015 editions human skin patch methods are carried out to test anti-acne combination
Thing I-IV and the negative control of every group of experiment (being free of test substances) carry out patch test, and according to dermoreaction grade scale
Record (as shown in table 7) is as a result, result is as shown in table 8.
The normal individual trial of table 7 tests dermoreaction grade scale
Table 8
As can be seen from Table 8, the result of human body patch test is shown, uses acne-removing composition I-IV 32 subject's skins
Skin has no adverse reaction, and shows that acne-removing composition I-IV has good safety in utilization to human body skin.
The foregoing is only a specific embodiment of the invention, but protection scope of the present invention is not limited thereto, any
Those familiar with the art the invention discloses technical scope in, change or replacement can be readily occurred in, should all be contained
Cover within protection scope of the present invention.Therefore, protection scope of the present invention should be based on the protection scope of the described claims.
Claims (10)
- A kind of 1. acne-removing composition, it is characterised in that in terms of the percentage by weight of the gross weight of the acne-removing composition, including with Lower component：Radish root tunning filtrate：10~50%；Fermented soybean product extract：10~50%；Chlorella tunning：15~35%；Rice bran tunning：5~25%.
- 2. acne-removing composition according to claim 1, it is characterised in that with the weight of the gross weight of the acne-removing composition Percentages, the addition of the radish root tunning filtrate is 20~40%；The addition of the fermented soybean product extract Measure as 20~40%；The addition of the chlorella tunning is 20~30%；The addition of the rice bran tunning is 10~20%.
- 3. acne-removing composition according to claim 1 or 2, it is characterised in that the radish root tunning filtrate, described The mass ratio of fermented soybean product extract, the chlorella tunning and rice bran tunning is 1~3:1~3:0.8~ 3:1, preferably 1.5~2.5:1.2~2.2:1.5~2.5:1.
- 4. according to the acne-removing composition described in claim any one of 1-3, it is characterised in that the radish root tunning filtrate For bright string coccus/radish root tunning filtrate.
- 5. according to the acne-removing composition described in claim any one of 1-4, it is characterised in that the fermented soybean product extract For the group of one or both of bacillus/fermented soybean product extract, Bacillus acidi lactici/fermented soybean product extract Close.
- 6. according to the acne-removing composition described in claim any one of 1-5, it is characterised in that the rice bran tunning is yeast The combination of one or both of bacterium/rice bran tunning, bacillus/rice bran extract tunning filtrate.
- 7. the preparation method of a kind of acne-removing composition according to claim any one of 1-6, it is characterised in that including by respectively The step of component mixes.
- 8. application of the acne-removing composition according to claim any one of 1-6 in cosmetics or skin care item.
- 9. application according to claim 8, it is characterised in that with the cosmetics or the weight of the gross weight of the skin care item Percentages are measured, the addition of the acne-removing composition is 1-15%, preferably 3%-10%.
- 10. application according to claim 8 or claim 9, it is characterised in that the cosmetics or the skin care item include aqua Type, gel formulation or emulsion-type.
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| CN108323531A (en) * | 2018-03-09 | 2018-07-27 | 深圳市容大生物技术有限公司 | A kind of function composition and its preparation method and application containing the antibacterial polypeptide of plant |
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| CN111514053A (en) * | 2019-11-06 | 2020-08-11 | 广州妮趣化妆品有限公司 | Composition with acne removing effect and preparation method and application thereof |
| CN111514053B (en) * | 2019-11-06 | 2023-02-07 | 广州妮趣化妆品有限公司 | Composition with acne removing effect and preparation method and application thereof |
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