JP2001163762A - Sliming agent - Google Patents

Abstract

PROBLEM TO BE SOLVED: To obtain a percutaneous sliming agent, promoting the decomposition and burning of subcutaneous fat, having a subcutaneous fat-reducing effect and useful for the prevention and treatment of obesity. SOLUTION: This sliming agent is provided by blending an extract obtained by extracting a plant belonging to family Bgnoniaceae, genus Tabebuia, with a skin cosmetic, skin detergent, percutaneous medicine, bath agent, or the like.

Description

DETAILED DESCRIPTION OF THE INVENTION

[0001]

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to a slimming agent effective for preventing and treating obesity, which has an effect of reducing subcutaneous fat by promoting metabolic decomposition and burning of fat in the human body. It is.

[0002]

2. Description of the Related Art Conventionally, for the prevention and treatment of obesity, Sanorex (Si) which inhibits re-entry of β-adrenaline at the nerve terminal and exerts an appetite suppressing effect for medical use.
kdar and Omura, Brain Res. Bull
l. , 15:33, 1985), brown fat cells and a thermogenic accelerator ephedrine, caffeine (Yoshioka et al., J. Nutr. Sci. Vitamino, which activates whole body metabolism).
l. , 36: 173-178, 1990), an ultra-low energy diet capable of maintaining a nitrogen balance (600 kcal, usually:
2000-3000 / day) Optifirst (Therapeutic Research, Ikeda et al., 10: 5)
037-5050, 1989), which is highly effective, but cannot be generally applied unless used under strict control of a physician due to side effects.

On the other hand, theophylline,
Soybean saponin, Plectrantas extract, etc. are known, and cosmetics containing capsaicin and hydroxytric acid as fatty acid metabolism promoters are known to have anti-obesity and slimming effects, and are esters of sucrose and fatty acids. Seaweed polysaccharides such as olestrella, lignin, agar, and carrageenan have been commercialized as diet foods. However, the above-mentioned capsaicin has an inflammation of the mucous membrane accompanied by a hot stimulus (Japanese Patent Application Laid-Open No. 60-262511).
It is known that the above-mentioned olestrella has side effects such as diarrhea, and the above-mentioned theophylline, hydroxy acid, etc. are not sufficient in effect, and soybean saponin, dietary fiber (Ono, obesity Medicine, 351-
372, 1993) has a problem that the effect is not obtained unless it is taken in a large amount, and at present there is no sufficient anti-obesity effect found yet.

On the other hand, an extract containing saponin declaring the action of removing meat (Japanese Patent Application Laid-Open No. 57-149215), a slimming agent containing 1'-hydroxyalkylxanthine utilizing a phosphodiesterase inhibitory action (Japanese Patent Application Laid-Open No.
No. 22813), a lipase activity accelerator (JP-A-09-301821) including an extract of coffee tree, eucommia and seaweed having an action of enhancing lipase activity, and an extract of fennel, inosit, and dextran sulfate for external use for body skin (Japanese Patent Application Laid-Open No. 05-262636) and a slimming agent composition for cosmetics containing a ginkgo extract having an α-2 receptor blocking effect (Japanese Patent Application Laid-Open No. 05-2218).
No. 42);
niaceae) A plant extract of the genus Tabebuia belonging to the genus Tabebuia is a bath agent demonstrating heat retention and deodorant effect (Japanese Patent Application No. 03-186953), and a hair restorer declaring the promotion of hair growth (Japanese Patent Application No. 07-125736, Japanese Patent Application JP-A-09-145788), anti-androgenic agents which declare acne prevention (JP-A-11-180819) and the like have been disclosed, but an external preparation containing a plant extract belonging to the genus Tabebuia belonging to the family Nostella spp. Having is something that was not yet known.

[0005] The present invention has been made in view of the above circumstances,
An object of the present invention is to provide a slimming agent which is absorbed from the human epidermis and has an effect of remarkably reducing subcutaneous fat and can prevent and treat obesity.

[0006]

SUMMARY OF THE INVENTION The present inventor has sought to solve this problem in view of the above-mentioned conventional problems and the current situation. An object of the present invention is to provide a slimming agent capable of preventing and treating obesity.

[0007]

Means for Solving the Problems The present inventors have made intensive studies on the above-mentioned problems and the like, and as a result, it has been found that a plant extract belonging to the genus Tabebuia of the family Agonaceae has an effect of promoting the reduction of subcutaneous fat in humans, and even if a large amount is incorporated. No obstacles, hence
The topical composition of the genus Taberuaceae, an anti-obesity active ingredient, is added to the topical composition to specifically and effectively reduce the subcutaneous fat at the application site without causing any adverse effects on the application site. The inventors have succeeded in obtaining a slimming agent of the above-mentioned purpose capable of preventing and treating obesity as an anti-obesity agent, thereby completing the present invention. That is, the slimming agent of the present invention is characterized by containing one or two or more species of the plant extract belonging to the genus Tabebuia of the family Acalymis.

[0008]

Embodiments of the present invention will be described below in detail. The slimming agent composition of the present invention (hereinafter, simply referred to as "the present invention") is a composition containing one or more kinds of extracts of a plant belonging to the genus Tabebuia of the family Sorrelaceae.

[0009] The genus Tabebuia of the family Pondaceae used in the present invention includes Caixetta (Tix
abebuia Cassinoides) and (T
abebuia leucoxyla), Iperosa: Ipe-rosa (Tabebuia impet)
iginosa), iperosho: Ipre-rox
o (Tabebuia heptaphylla), Ipecomn: Ipe-comm (Tabebuia
velozoi), Carobira: Carobira
(Tabebuia caraiba), Ipea-mareiro: Ipe-amarelo (Tabebuia c
hrsotricha) and (Tabebuia u
mbellata), Pau Darco Amarero: Pa
u-darco-amarelo (Tabebuia
serratifolia) and the like. It is a new finding of the present inventors that the slimming agent prepared by mixing one or more of these plant extracts has the attribute of having the above-mentioned subcutaneous fat reducing effect. . This point and the like will be described in detail in Test Examples and the like described later.

[0010] The extract of the present invention can be used for bark, xylem,
Using leaves, flowers, fruits or roots, when extracting, the plant may be in an undried state, but preferably it is dried and dried by a method such as air-drying or freeze-drying in terms of extraction efficiency. desirable. As a method for extracting the extract, a normal extraction method is employed, and the extraction can be performed using water, a sodium chloride solution, a hydrophilic organic solvent, a hydrated hydrophilic organic solvent, another organic solvent, or the like.

The hydrophilic organic solvent used in the extraction includes lower alcohols such as methanol, ethanol and isopropanol, glycols such as propylene glycol and 1,3-butylene glycol, glycerin, acetone, methyl ethyl ketone, acetonitrile, dimethyl sulfoxide, and the like. Examples thereof include dimethylformamide and the like, and a mixture thereof. In particular, it is preferable to perform extraction using water or a mixture of water and a lower alcohol such as methanol, ethanol, or isopropanol. In this case, the ratio of water to lower alcohol is 0/100 for lower alcohol / water.
７０70/30 (V / V: volume ratio), more preferably 0/100１００40/60.

The ratio between the dried plant and the extraction solvent is as follows:
The dried plant / solvent ratio is preferably in the range of 1/50 to 1/2 (W / W: weight ratio). Also, as the extraction conditions,
The extraction temperature is not particularly limited, but it is preferable to carry out the stirring at a temperature of 5 to 80 ° C., preferably 5 to 50 ° C. for 1 to 24 hours while stirring, and the extraction pH is inclined to extreme acidity and alkalinity. There are no particular restrictions.

The extraction efficiency can be increased by repeating the extraction operation on the extraction residue generated in the above extraction operation. The extract may be used as it is, or may be used as a diluent or as a concentrated extract, or may be prepared as a dry powder by freeze-drying or the like, or may be prepared in a paste form. When prepared into the dry powder, methanol or ethanol containing water, ethanol, ethanol or a lower alcohol such as isopropanol may be used by previously dissolving or used after solubilization in an external composition containing water described below. Is preferred.

The slimming agent of the present invention can be mixed with the extract obtained above at any concentration. The amount of the slimming agent to be compounded varies depending on the product form, but is generally 0.01 to 50% by weight, preferably 0.05 to 20% by weight.
%, More preferably 0.1 to 10% by weight. If it is less than 0.01% by weight, a satisfactory obesity prevention effect may not be exhibited, and if it exceeds 50%, no further effect is usually exhibited. In the case of a bath agent, it is diluted to tens of thousands in use, but since the temperature of the hot water is higher than the body temperature, the pores open, and it is easy to absorb the extracted components, the above amount should be ensured in the bath dosage form. Is enough.

[0015] The slimming agent of the present invention includes, in addition to the above-mentioned plant extract of the genus Tabebuia, which is a subcutaneous fat-reducing component,
Oil, water, surfactant, moisturizing, lower alcohol, thickener, antioxidant, chelating agent, pH adjuster, preservative, fragrance, coloring matter, ultraviolet absorber, ultraviolet scattering agent, vitamins,
Raw materials commonly used for cosmetics, soap baths and the like such as amino acids and water can be blended. Incidentally, the optional components to be added to the external preparation composition of the present invention are not limited to these, and for example, extracts of animal, microbial and plant origin can be added as appropriate.

[0016] The slimming agent of the present invention thus constituted is a lotion (lotion), cosmetic cream, emulsion, lotion, pack, skin milk (emulsion), gel, powder, lip balm, lipstick , Under makeup, foundation, sun care, bath agent, body shampoo, body rinse, soap, cleansing foam, ointment, patch, jelly agent, aerosol agent, etc., can be used as various slimming agents. But are not limited to these. These products can be produced by appropriately mixing the Tabebuia plant extract of the present invention with the above-mentioned optional components. In addition, the above Tab used in the present invention
The ebuia plant extract is a highly safe product, and therefore can be widely used as the anti-obesity agent of the above-mentioned various dosage forms.

[0017]

DESCRIPTION OF THE PREFERRED EMBODIMENT
Oniaceae) The present invention will be specifically described with reference to production examples of a plant extract of Tabebuia genus, but the present invention is not limited to the following examples. Note that “%” in each example is “% by weight”.

[Example of production of plant extract: Tabebui
Example of a chrsotricha] Fam. Bignoniaceae Tabebui
apea mareiro (Tabebuia c
hrsotricha) 100 g of the dried bark was immersed in 2 liters of methanol and extracted at room temperature for 3 hours with stirring. Thereafter, the resultant was concentrated and freeze-dried to obtain 2 g of Tabebuiachrsotricha extract. In addition, various extracts of other Tabebuia genus plants can be obtained in accordance with the above-mentioned production method. [Example of plant extract production: Tabebuia hept
aphylla] Family Cranaceae (Fam. Bi
gnoniacae) Iberosho (Tabebuia heptaphy) belonging to the genus Tabebuia
lla) 100 g of dried leaf was immersed in 2 liters of acetone and extracted at room temperature for 3 hours with stirring. After that, it was concentrated and freeze-dried to obtain Tabebuia.
1.5 g of heptaphylla extract was obtained. or,
Various extracts of other Tabebuia genus plants can be obtained according to the above-mentioned production method.

[Test Example 1] Degradation of fat is measured by a method in which a specimen is allowed to act on free white adipocytes, which is widely used as a screening method for slimming agent development, and the amount of released fatty acids is measured (Ezaki: History of Medicine vol 184). N
o. 6 1998). That is, SD-IG
Free adipocytes prepared from epididymal adipose tissue of S male rat (body weight: 200-300 g) using a collagenase solution were diluted at 37 ° C. in an albumin-bicarbonate buffer solution diluted to a sample concentration of 100 μg / ml. Hatch for 2 hours,
The amount of free fatty acids in the reaction solution is determined using a free fatty acid measurement kit (NE
FA-Test; Wako: enzymatic method using acyl-COA oxidase). In addition, as a comparative control, two points of Garcinol extract and Kola extract used as lipolysis promoting components of a commercially available slimming agent were used for the test.

[0020]

[Table 1]

[Test Example 2] Hydrophilic ointment / white petrolatum was 1
A slimming agent was prepared by mixing the above extract with a base compounded at a ratio of / 1 (weight ratio) to 1.0%.
The following tests were performed using two commercially available slimming agents A (containing garcinol, caffeine, and keratrine) and B (containing pectrantas, cola, and cassava) as controls. [Test method] Six adult males and females (two males and four females) were used as subjects, and the above sample was applied to the upper right arm of each subject at least twice a day. The subcutaneous fat thickness of the left (uncoated part) and right (sample-coated part) subcutaneous fat thickness was measured by an ultrasonic diagnostic apparatus (UX-1: Rion Co., Ltd.) at 4 weeks in total, and the following formula The reduction rate was calculated and judged from the average value of 6 subjects according to the following evaluation criteria.

(Equation 1)

Evaluation Criteria Based on the values, the slimming effect was evaluated based on the following four criteria. -(No effect) .... The subcutaneous fat reduction rate is 5% or less ± (Some effect) ... The subcutaneous fat reduction rate is 6 to 10% + (Effective) ... The subcutaneous fat reduction rate Is 11-1
5% ++ (Effective effect) .. The subcutaneous fat reduction rate is 16 or more. Table 2 shows the subcutaneous fat reduction rate and the evaluation results.

[0023]

[Table 2]

Hereinafter, the slimming agent of the present invention is used as a cream,
Emulsion, lotion, bath agent (granular), bath agent (powder),
Bath agent (tablet), bath agent (foaming agent), bath agent (liquid),
Specific examples when applied to body shampoo and body rinse will be described. In addition, what was manufactured similarly to the said manufacturing example was used for the various extracts of each Example.

[Examples 1 to 9] Table 3 shows examples of skin creams.

[Table 3] It was blended as in Examples 1 to 9 to obtain a skin cream having a slimming effect.

[Examples 10 to 18] Examples of emulsions are shown in Table 4.
It was shown to.

[Table 4] By blending as in Examples 10 to 18, an emulsion having a slimming effect was obtained.

[Examples 19 to 27] Table 5 shows examples of the lotion.

[Table 5] By blending as in Examples 19 to 27, a lotion having a slimming effect was obtained.

[Example 28] Bath agent (granular) Sodium sulfate 30.0% by weight Magnesium oxide 2.0 Sodium carboxymethylcellulose 1.0 Tabebuia casinoides methanol extract 2.0 Chamomile 0.5 Vitamin E 0.5 Flavor 1.0 Dye 0.1 Potassium hydrogen carbonate Balance (total) 100.0 With the above composition, a bath agent (granular) having a slimming effect was obtained by a conventional method.

Example 29 Bath agent (powder) Sodium bicarbonate 32.0% by weight Tabebuia caraiba methanol extract 2.0 Pepsin enzyme (200 U) 1.0 Sodium citrate 3.0 Limonene 0.5 Lavender oil 0.3 Fragrance 1.0 Dye 0.1 Sodium carbonate Balance (total) 100.0 Bath compound (powder) having a slimming effect was obtained by the usual method with the above composition.

Example 30 Bath agent (tablet) Sodium bicarbonate 25.4% by weight succinic acid 40.0 Tabebuia caraiba methanol extract 1.5 Aloe powder 0.5 Tabebuia impetiginosa methanol extract 0.5 Tabebuia leucoxyla methanol Extract 0.5 Perfume 1.0 Dye 0.1 Sodium carbonate Balance (total) 100.0 With the above composition, a bath preparation (tablet) having a slimming effect was obtained by an ordinary method.

Example 31 Bath agent (foamed) Sodium sulfate 8.0% by weight Sodium bicarbonate 30.0 Tabebuia umbellata methanol extract 0.5 Tabebuia heptaphylla methanol extract 0.5 Tabebuia chrsotricha methanol extract 5 Citric acid 20.0 Tartaric acid 10.0 Succinic acid 10.0 Dye 0.5 Fragrance 1.5 Sodium carbonate Balance (Total) 100.0 With the above composition, a bath agent (foaming) having a slimming effect by a standard method. Obtained.

Example 32 Bath Agent (Liquid) Ethanol 20.0% by Weight Sodium Sulfate 5.0 Tabebuia velozoi Methanol Extract 1.0 Lanolin 0.5 Avocado Oil 0.5 Pigment 1.5 Perfume 21.0 Propylene Glycol balance (total) 100.0 With the above composition, a bath agent (liquid) having a slimming effect was obtained by a conventional method.

[0033]

Example 33 Body shampoo 5.0% by weight potassium coconut fatty acid Potassium oleate 20.0 Coconut fatty acid diethanolamide 3.0 Glycerin 10.0 Sodium sulfate 2.0 EDTA 0.1 Tabebuia serratifolia Methanol extract 1.0 Fragrance Appropriate amount Dye Appropriate amount Preservatives Appropriate amount Purified water Balance (total) 100.0 With the above composition, a body shampoo having a slimming effect was obtained by a conventional method.

Example 34 Body Rinse Liquid Paraffin 10.0% by Weight Isopropyl Palmitate 3.0 Methylpolysiloxane 3.0 Glycerin Monostearate 1.5 POE Glycerin Stearate 1.5 Glycerin 5.0 Tabebuia heptaphylla Methanol Extract 0.2 Perfume Appropriate amount Pigment Appropriate amount Preservative Appropriate amount Purified water Balance (total) 100.0 With the above composition, a body rinse having a slimming effect was obtained by a conventional method.

[Example 35] Patch Tabebuia leucoxyla methanol extract 0.1% by weight Polyacrylic acid 5.2 Sodium polyacrylate 1.2 Polyvinyl alcohol 3.0 Sodium carboxymethylcellulose 4.0 Glycerin 5.0 Polyethylene glycol 400 2.0 1-Menthol 0.1 Synthetic hydrotalcite 0.2 Purified water Balance (Total) 100.0 With the above composition, spread on a non-woven fabric support by a conventional method, carry it, and cover it with a protective film. A patch having a slimming effect was obtained. Since the patch can be in contact with the skin for a long time, Tabebuia leucoxyl
a About 0.1% of methanol extract is sufficient. In addition, the patch is effective when it is targeted at the abdomen, buttocks and the like.

Example 36 Ointment Tabebuia heptaphylla methanol extract 0.3% by weight POE cetyl ether (30E0) 2.0 glyceryl monostearate 10.0 liquid paraffin 5.0 cetyl alcohol 6.0 methyl paraben 0.1 Propylene glycol 10.0 Purified water Balance (total) 100.0 An ointment having a slimming effect was obtained by the usual method with the above composition.

Example 37 Packing agent Tabebuia cassinoides methanol extract 0.2% by weight POE hydrogenated castor oil (20E0) 0.5 Polyvinyl alcohol 12.0 Ethanol 5.0 1,3-butylene alcohol 6.0 Methyl paraben 0 1.1 Appropriate amount of perfume Purified water Balance (total) 100.0 With the above composition, a pack having a slimming effect was obtained by a conventional method.

[0038]

The present invention has an excellent subcutaneous fat reduction-promoting effect and can effectively reduce subcutaneous fat particularly for the whole body or locally. Therefore, it is useful as a slimming agent in beauty and medicine.

Continued on the front page F-term (reference) 4C083 AA111 AA112 AA122 AB032 AB212 AB312 AB352 AB442 AC012 AC022 AC072 AC102 AC172 AC292 AC302 AC352 AC422 AC442 AC482 AC532 AC542 AC582 AC642 AD042 AD092 AD112 AD152 AD212 AD272 AD352 AD472 AD512 CC532 CC05 CC05 DD12 DD15 DD16 DD17 DD23 DD31 EE50 FF01 4C088 AB12 BA08 CA03 MA63 NA14 ZA89 ZC35

Claims (1)

[Claims] [1] The family of the family Agonaceae (Fam. Bignon)
(iaceae) A slimming agent containing a plant extract of the genus Tabebuia.