JP2006257067A - Production method of sasa albo-marginata extract, sasa albo-marginata extract and its use - Google Patents

Abstract

<P>PROBLEM TO BE SOLVED: To provide a production method of Sasa albo-marginata extract, and to provide use of the extract. <P>SOLUTION: The production method of the Sasa albo-marginata extract uses Sasa albo-marginata compressed residue obtained by squeezing green leaves and stems of the Sasa albo-marginata to remove juice, and comprises adding water thereto and extracting active components of the Sasa albo-marginata in an open or closed vessel at 60-210°C to produce extracts of the Sasa albo-marginata, or comprises soaking the raw material in 50 wt% ethanol-water mixture to extract the active components and removing ethanol. And hair-growing and hair-fostering agents, cosmetics and health foods, which are compounded with the Sasa albo-marginata extracts, are provided. <P>COPYRIGHT: (C)2006,JPO&NCIPI

Description

  The present invention is to squeeze fresh leaves and stems of the genus Kumazasa as a primary raw material, and to effectively use the pressed residue after obtaining the pressed juice. As a secondary raw material), after adding water, heat treatment is performed in an open or closed container at 60 to 210 ° C. The present invention relates to a method for producing a genus extract, and also relates to a method for producing an extract of the genus Kumaza, which immerses the secondary raw material in an ethyl alcohol / water mixture and extracts an active ingredient contained in the secondary raw material. In addition, the present invention relates to use in cosmetics and health drinks containing this Kumazasa extract, and in particular, use in a hair nourishing agent.

  Conventionally, as a method for extracting an active ingredient from Kumazasa (Kumamine or Koji), a method of obtaining a raw extract after concentration by sterilizing a liquid obtained by squeezing fresh leaves at 15 ° C. or less with 10% ethyl alcohol (for example, Patent Document 1) A method for obtaining a water-soluble concentrated extract by immersing and boiling dry leaves (for example, see Patent Document 2), a method for obtaining an extract by steaming leaves and straws at high temperature and high pressure (for example, see Patent Document 3), After obtaining raw solution by high-pressure squeezing raw leaves and straw at room temperature, the extract is obtained by fractionating at high temperature (see, for example, Patent Document 4) After extracting the substances, a method of extracting water-soluble substances with water alone (see, for example, Patent Document 5), extracts extracts of plants and mushrooms with a pressurized hot water extractor, and the residue is a saturated steam pressurized heat treatment Extract again with a machine and efficiently And a method and apparatus to obtain the 'products (for example, see Patent Document 6) are known.

Furthermore, as a skin protection composition using Kumazasa extract as an active ingredient, a composition containing an extract obtained by extracting fresh leaves or dried leaves with water at 60 to 130 ° C. at normal pressure or pressure (for example, patent documents). 7), as a hair nourishing / hair-growth material, a hair cosmetic (for example, refer to Patent Document 8), which combines a cedar extract and a blood circulation promoter such as a nicotine derivative, a plant extract such as Kumazasa extract, chili pepper tincture, etc. Known is a hair restoration (for example, see Patent Document 9) in which a fatty acid or alcohol having a chain length is combined with a plant extract such as Kumazasa extract or Gentian extract.
As for Kumazasa, Dr. Tomita Makino published in the “Botany Journal” published on February 20, Meiji 34, “Suzutake”, “Azumazasa”, “Miyakozasa”, “Kumazasa”, “Kokuzasa” , “Chimakiza”, “Shakotanza”, “Kumizaza”, “Miyazaza”, “Ohokuzasa”, “Chishimaza”, etc., are 11 species of the genus Bambusa in bamboo. It was proposed that a new genus should be provided with the name of the genus Kumaza because it differs in part structure and form (see Non-Patent Document 1, for example).
Japanese Patent Laid-Open No. 01-187071 Japanese Patent No. 1703690 JP 62-148425 Japanese Patent 2002407 JP2003-116480 Japanese Patent No. 3212278 JP2003-201247 JP 2001-288049 JP-A-10-45539 Tomita Makino; Plant taxonomy research, p.182-183, Seikodo Shinkosha (issued on December 21, 1927)

As described above, raw leaves or dried leaves have been mainly used as a raw material for obtaining the extract of Kumazasa (Kuma persimmon or persimmon), but a method using ginger (stem) or dry persimmon (stem) as a raw material. (The above-mentioned patent documents 4 and 5) are also known. Furthermore, in order to obtain an extract of kumabuchi or kumazasa, as a general method, a method of extracting dried leaves by immersing in water for a long time, a method of immersing in water and then heating and boiling, a method of extracting at high temperature under water, A method of extracting leaves and stems with an alcohol / water mixture is known.
However, when raw leaves and stems are used as raw materials, cell conjugates and active ingredients contained in the hard fiber tissue of bamboo leaves and stems cannot be satisfactorily extracted, and Kumazasa is effectively used without waste It was not made.
In addition, when dry leaves and stems are used, they can be finely pulverized by drying, but the fiber structure becomes hard and extraction of the active ingredients present inside becomes even more difficult. By drying, alteration of the active ingredient is caused, and it is considered that the extract is different from the state in which it is present in the raw leaves and stems.
The present invention relates to a method for efficiently extracting a cocoon, which is a limited resource, without waste by extracting a rare natural component with a high value contained in a residue after squeezing ginger of the genus Kumazasa. The issue is to provide. In the present invention, the pressed residue obtained after high-pressure pressing in advance at room temperature in advance, that is, by effectively using the secondary material, is contained in the hard fiber tissue of fresh leaves and stems that could not be extracted conventionally. The present invention provides a method capable of obtaining an active ingredient and bound water.
Furthermore, the water extract or ethyl alcohol / water mixture extract is distilled off under heating, and it is suitable for cosmetics with little coloration, tasteless odor and excellent safety to the skin, especially for hair restoration and hair restoration. In addition to obtaining an extract of the genus Kumaza, there is also obtained an extract of the genus Kumaza that is less colored, has no unpleasant odor, has no astringency, and is suitable for health drinks.

  In order to solve the above-mentioned problems, the present inventor has intensively studied various plant extraction methods and extracts, and has antibacterial and moisturizing properties, and is safe for human skin and a cosmetic material, health food, and beverage Search for prescriptions as raw materials, and press the raw leaves and stems of the genus Kumazasa to obtain compressed juice, and then use heated residue at 60-210 ° C in an open or closed container, or with heated water while stirring Extracts obtained by extracting the active ingredients and tissue water contained in the pressed residue by contact with or in an ethyl alcohol / water mixture at room temperature are used in cosmetics used for human skin, especially hair nourishment. -It has been found out that it is suitable as a blending component of a hair restorer and suitable as a blending component of a health drink, and has reached the present invention.

  In other words, the present invention (1) shreds the primary raw material of the genus Kumazasa (Koji or Kumagusu) at room temperature and compresses the shredded material at room temperature and high pressure to extract a stock solution of medicinal substances in the protoplasm The secondary raw material is obtained, dried and pulverized, and the pulverized product is hydrolyzed with hot water to decompose the polysaccharide, thereby extracting monosaccharides and oligosaccharides. Non-chemical two-step treatment method for ginger of the genus Kumazasa (隈 笹 or Kumakuma), (2) Squeeze fresh leaves and stems of the genus Kumazasa as the primary raw material, As a secondary material, a method for producing an extract of the genus Kumazasa characterized by extracting an active ingredient after hydration; (3) after hydration to the secondary material according to 2, the temperature is 60 to 210 ° C. in an open container or a sealed container A method for producing a Kumazasa extract, characterized by heat treatment 2) A method for producing an extract of the genus Kumaza, wherein the active ingredient is extracted by immersing the secondary raw material described in 2 in an ethyl alcohol / water mixture at room temperature, and (5) 50% of the ethyl alcohol / water mixture is produced. 4. A method for producing an extract of the genus Kumazasa according to 4, which is a mixed solution containing ethyl alcohol in an amount of not more than% by weight; (6) after adding water to the secondary raw material according to 2, 60 ~ 2. The Kumazasa extract according to 2 or 3, wherein the Kumazasa extract is obtained as a distillate and an evaporation residue after being subjected to heat treatment at 210 ° C. and then fractionated without removing solids. (7) The secondary raw material described in 2 is immersed in water containing 50% by weight or less of ethyl alcohol at room temperature, and then the liquid obtained by separating the solid content is heated to obtain ethyl alcohol and Characterized by distilling off water 4 or 5, wherein (8) the ethyl alcohol and water are distilled off, and the mixture is further replaced with an aqueous solution, followed by fractional distillation at 70 ° C. or lower under reduced pressure. The method for producing an extract of the genus Kumaza of 7 above, (9) the extract of the genus Kumaza obtained by the method of production of 2, 3, 4, 5, 6, 7 or 8; A hair nourishing / hair-growth agent comprising a product, (11) a cosmetic comprising the Kumazasa extract described in 9, and (12) a health drink comprising the Kumazasa extract described in 9, .

By completing the present invention, it has become possible to effectively use the genus Kumazasa which is a natural resource.
Attempts to recycle the compressed residue after high-pressure compression of the genus Kumazasa has not been made in the past, and is also a useful method from the viewpoint of resource protection.
This method is a milder method that can greatly prevent destruction and denaturation of the active ingredients inherent in koji compared to other methods that use acids and high temperatures. It is extremely effective for hair and hair growth, and is excellent as a cosmetic and health drink.

As the raw material of the genus Kumazasa used in the present invention, all the Kumazasa Sasa that grow naturally in Japan can be used, but Kumazasa and Chishimasasa that grow naturally on a clean land away from the human sphere of life are preferable.
As soon as possible to cut down the bamboo indigenous to kumazasa genus, at a normal temperature without dividing the leaves and stems, and under high pressure compressed to about ^{200 kg / cm 2 ~700kg / cm} 2, squeezing residue after obtaining the squeezed juice The object appears to be almost dry in appearance. However, it is generally said that even if the plant is sufficiently dried, the tissue-bound water still remains about 10%, so that a sufficient amount of the active ingredient and the bound water remain in the tissue of this Kumazasa pressed residue. It can be said that.
Of course, in order to increase the compression efficiency, it is preferable to shred the scorpion of the genus Kumazasa cut before squeezing.
In the present invention, (1) when water is used as an extraction medium, the component can be extracted by heating in an open container or a closed container at 60 to 210 ° C. or by contacting with heated water while stirring. In general, it is said that carbohydrates in plants cause hydrolysis when heated at a temperature exceeding 160 ° C., but there is no problem for the purpose of the present invention. (2) In the case of extraction with an ethyl alcohol / water mixture, the pressed residue is immersed in a mixture containing 50% by weight of ethyl alcohol at room temperature for 1 to several months for extraction. If the immersion time is shorter than one month, the extraction efficiency is poor, and if it is immersed for several months or more, the extraction efficiency is improved but it is not economical.
When water is used as the extraction medium, the aqueous solution obtained by removing the solid matter by filtering once, or in a container containing the solid matter without filtration, it is extracted by fractional distillation at about 70 ° C. or less under reduced pressure. An extract is obtained.
Even if the aqueous solution obtained by removing solids by filtration in the above process can be used for the intended purpose of the present invention, it has a bitter taste, so it is used in cosmetics and beverages. Somewhat unsuitable for. Therefore, in order to obtain a clear and tasteless Kumazasa extract, it is preferable to obtain a distillate extract by fractional distillation at about 70 ° C. or less under reduced pressure.

If the ethyl alcohol concentration of the ethyl alcohol / water mixture exceeds 50%, the extraction rate of soluble components is lowered, and there is a problem in handling as a combustible material.
When an ethyl alcohol / water mixture is used as an extraction medium, solids are removed by filtration, and then the filtrate is distilled off together with water at about 50 ° C. or less under reduced pressure, and then replaced with an aqueous solution again. The extract is obtained by fractional distillation under reduced pressure at about 70 ° C. or lower.
Even if the aqueous solution in which ethyl alcohol is substituted with water in the above process is used as it is, it can be used for the intended purpose of the present invention, but it is more astringent than the case where water is used as an extraction medium, and is blended in cosmetics and beverages. Slightly unsuitable for use.
Therefore, in order to obtain a clear and tasteless extract of the genus Kumazasa, it is preferable to obtain it by fractional distillation at about 70 ° C. or less under reduced pressure.
Even if ethyl alcohol in the final extract of the genus Kumazasa is used only as a cosmetic formulation, there is no problem even if it remains in a few wt%, but for the purpose of formulating it as a health beverage, it is almost completely water. It is desirable to be substituted with.
The extract of the genus Kumazasa obtained as described above is less colored, has no odor, tastes good to the skin, is easy to blend into cosmetics, has no astringency, and has a rather sweet taste. And is easy to formulate into health drinks.
The Kumazasa extract obtained using water as a medium and the Kumazasa extract obtained using an ethyl alcohol / water mixture as a medium may be used alone or in combination at any ratio.
The ethyl alcohol in the final Kumazasa extract, if used only as a cosmetic compounding agent, can remain at a few percent by weight or less, but for the purpose of formulating as a health drink, it is almost completely Must be replaced with water.

The evaporation residue obtained after obtaining a distillate extract using either water or ethyl alcohol / water mixed solution as an extraction medium can also be used by partially mixing the distillate extract.
As the extraction medium used in the present invention, tap water can be used, but clean spring water, ion-exchanged water, or distilled water that is not sterilized with chlorine is desirable.
In addition, the ethyl alcohol used in the present invention is preferably brewing ethyl alcohol that is specified for use in food processing in Japan.

It is said that the number of hairs of a healthy Japanese person is about 100,000, but if the hair cycle is about 5 years, the number of hair loss per day is about 55.
Today, with changes in living environment and eating habits, the types of alopecia are also increasing. According to the general classification of these alopecias, Tetsuo Inoue and Yoichi Yagihara “Science and Diagnosis of Hair (Revised)” (Pharmaceutical Daily Report 04, 2002.2.1), resting hair loss alopecia, growth It is divided into stage hair loss.
Resting hair alopecia includes male pattern alopecia (juvenile alopecia / aged alopecia), postpartum alopecia, post-pill alopecia, seborrheic alopecia, hair loss due to thyroid dysfunction, hair loss due to diet Vitamin A alopecia, drug-induced alopecia, traction alopecia and the like. Growth alopecia includes alopecia areata, pressure alopecia, drug-induced alopecia, and syphilitic alopecia.
Hair restorers are products for keeping the scalp and hair healthy. In Japan, there are hair restorers belonging to cosmetics and hair regrowths (correctly hair restorers) belonging to quasi-drugs in accordance with the Pharmaceutical Affairs Law.
Hair nourishment suppresses dandruff and itching, replenishes moisture and oils that tend to be deficient, and keeps the hair and scalp healthy. Hair restorer prevents hair growth, hair loss prevention, hair growth promotion, dandruff and itching. It has more direct hair-growth effects, such as suppression, and many of them are allowed to be labeled with “medicinal” in their names, such as medicinal hair-growth agents and medicinal hair growth promoters.
The function of the hair restorer is to expand peripheral blood vessels and increase blood flow, so that the hair papilla works normally, gives the hair matrix cells the necessary nutrients and energy, makes healthy hair, and promotes root metabolism. Is done. Hair matrix cells divide and proliferate, differentiate and produce hair and grow, and a hair growth effect appears. In addition, it has functions such as promoting hair growth, preventing hair loss, post-sickness and postpartum hair removal, hair growth, hair nourishing, thinning hair, etc. and suppressing dandruff and itching.

As ingredients of the hair restorer, the following ingredients are used.
(1) Peripheral vasodilators are local stimulants that stimulate the scalp and raise skin temperature, chili tincture, ginger tincture, menthol, mint oil, camphor, benzyl nicotinate, ginseng extract of blood circulation promoter, Other examples include garlic extract, assembly extract, vitamin E, capronium chloride, gentian extract, and cephalatin.
(2) As a hair metabolism activator, substances necessary for activation of skin respiration-related enzymes necessary for hair growth and energy supply to hair matrix cells are blended. Examples thereof include pantothenic acids, chlorophyll, hinokitiol, placenta extract, glyceryl pentadecanoate, and photosensitizer.
(3) As a nutritional supplement, vitamins A, B2, B6, C, D, H, etc., as well as vitamins A, B2, B6, C, D, H, etc., as well as amino acids unique to hair, cysteine, methionine, serine and the like are blended.
(4) Antiseborrheic agent is a component that suppresses sebum secretion that causes dandruff, and includes sulfur, thioxolone, vitamin B6, and derivatives thereof.
(5) As a bactericidal agent, it is a component for suppressing the activity of microorganisms that use sebum as a nutrient, and contains chlorhexidine hydrochloride, quaternary ammonium salt and photosensitizer.
(6) As the keratolytic agent, salicylic acid, resorcin, lactic acid, and the like are blended as components for preventing swelling by swelling before the keratin becomes too thick.
(7) As an antipruritic / anti-inflammatory agent, diphenhydramine hydrochloride and glycyrrhetinic acid are blended to prevent itching.
(8) As a moisturizer, glycerin, pyrrolidone carboxylic acid, hyaluronic acid, etc. are used for dandruff due to drying of the scalp keratin to maintain keratin softness and moisture, and castor oil, etc. is used for dandruff due to keratin oil. Used.
(9) Antibacterial agents include piroctone olamine and miconazole nitrate.

It is unclear at this stage that the Kumazasa extract of the present invention exerts a hair-restoring / hair-growth effect by any mechanism of action, but in consideration of the components used in the above-mentioned normal hair-restoration / hair-growth agents, It is surmised that the Kumazasa extract of the invention promotes peripheral blood vessel dilation and hair metabolism activity.
Ingredients used in the production of cosmetics by blending the extract of the genus Kumazasa of the present invention include those usually used in cosmetic liquids such as lotions and emulsions, solid soaps, such as moisturizers, pH adjusters, antibacterial agents Agents, astringents, antioxidants, pigments, perfumes and / or stabilizers. In addition, in the case of producing a hair nourishing and hair restorer by blending the Kumazasa extract of the present invention, the aforementioned peripheral vasodilator, hair metabolism activator, nutritional supplement, antiseborrheic agent, Antibacterial agents such as bactericides, keratolytic agents, antifungal / anti-inflammatory agents, humectants, antibacterial agents, dyes, fragrances and / or stabilizers.
Furthermore, when a health drink is produced by blending the Kumazasa extract of the present invention, vitamin agents, acidulants, sweeteners, sugars, amino acids and the like that are usually used in food production can be blended. However, it is not limited to these.
In addition, if necessary, the citrus mushroom extract subjected to deodorization / decolorization treatment by filtration with activated carbon according to a conventional method, or after deodorization / decolorization treatment with activated carbon, can be spray-dried and used as a powder.
Hereinafter, as examples of the extract of the genus Kumazasa of the present invention, examples of the koji extract and the chishimasa extract are given.

Shred the salmon ginger with a shredder. The shredded ginger as the primary raw material is squeezed under high pressure up to about 400 kg / cm ² at room temperature using a squeezing machine. The analysis results shown in the analysis test report in Table 1 were obtained from 100 g of sap (sasa) sap / extract 100% obtained through the pressing process of the primary treatment.

  The secondary raw material after the primary treatment is dried and then pulverized, and from the sap 100 g obtained by hydrolyzing it with hot water, the analytical results shown in the analytical test report of Table 2 was gotten.

As is clear from the above analysis results, secondary treatment of hydrolysis with hot water after extraction of components that can be denatured by heat, such as amino acids contained in ginger, in the normal temperature high pressure pressing process by primary treatment It is clear that no amino acids have been extracted.
However, when hydrolyzed with hot water, polysaccharides having a large number of binding molecules are thermally decomposed to extract aspartic acid, glutamic acid, glycine, alanine, valine, and the like.
The remaining residue that has undergone the primary treatment and the secondary treatment can be mixed and used as livestock feed by appropriate processing, such as mixing with other products and subjecting to fermentation.

1. Preparation of raw materials for extraction;
50 kg of Chishimasasa containing fresh leaves and stems harvested from Chishimazasa's own dough is shredded to a length of about 10 to 30 mm, and then pressed under a high pressure of about 470 kg / cm ² to obtain 4 kg of squeezed juice, ) 45kg was obtained.
2. Extraction method of Chishimazasa extract (1) Extraction by boiling under normal pressure using water as a medium 300 g of the above Chishimazasa press residue (I) is collected after air drying, together with 3,500 g of commercially purified water, the volume is 5 liters. It was put into smoked pasta bread. This was heated with an electromagnetic induction-type electric heater, boiled and extracted at a liquid temperature of about 95 ° C. for 13.5 hours, cooled to room temperature, and filtered to obtain 2,087 g of a light brown liquid.
<Confirmation of high boilers>
In order to confirm the abundance of high-boiling substances by evaporating and drying the liquid, 100 g of the liquid was evaporated to a final vacuum of 20 hPa using a rotary evaporator while keeping the bath temperature at 45 ° C and being careful of bumping. Drying gave 0.975 g of evaporation residue. This evaporation residue was found to correspond to about 6.38% when calculated with respect to the raw material pressing residue.
<Collecting extract>
Using the rotary evaporator, the remaining 1,486 g of the filtrate was again maintained at a bath temperature of 45 ° C., and 1,220 g of the liquid distilled up to a final vacuum of 20 hPa was recovered.
The collected fractionated liquid was a pale yellow transparent liquid having a sweet and pleasant scent.
The evaporation residue was a liquid having a light brown viscosity.
The physical properties of the extract of Chichimasasa prepared by the above method are as follows.
Carbohydrates 0.7% or less Proteins 0.06% or less Lipids 0.01% or less Ash 0.07% or less Water 99.16% or more The Chishimasa extract is a transparent liquid with an unpleasant smell, Suitable for use as a beverage compounding agent.

(2) Extraction with pressurized hot water 60 kg of Chishimazasa pressure residue (I) was charged into a 200-liter pressure vessel equipped with a stirrer and injected with 100 kg of purified water.
A high pressure steam of 12 kg / cm ² was injected into the jacket, the contents were kept at about 180 ° C., and the active ingredients were extracted from the squeezed squeezed residue while heating and stirring for 5 hours, and the saccharides were hydrothermally decomposed.
<Collecting extract>
When cooling water is poured into the jacket in the container and the liquid temperature reaches 70 ° C. while continuing the stirring, the system is gradually depressurized by a vacuum pump, and while the final pressure of 50 hpa is reached, Was distilled as a distillate containing an active ingredient to obtain 63 kg.
The collected fractional distillate was a pale yellow and transparent aqueous solution having a sweet and pleasant scent.
The evaporation residue was a light brown viscous liquid and extraction residue.
The physical properties of the extract of Chichimasasa collected by the above method are as follows.
Carbohydrate 0.8% or less Protein 0.08% or less Lipid 0.1% or less Ash 0.06% or less Water 98.96% or more

(3) Extraction with 20 wt% ethyl alcohol / water mixed solution 250 g of squeezed squeezed residue (I) is placed in a glass container with a lid of 5 liters in inner volume, and 2500 g of an aqueous solution of 20% by weight of reagent-grade ethyl alcohol prepared in advance is added. It was stored at room temperature in a dark place for 106 days. During this time, the container was occasionally shaken to mix the contents.
<Collecting extract>
After 3 months, the above contents were filtered using a suction funnel to recover 1590 g of the filtrate.
Using a rotary evaporator, maintain the bath temperature at 45 ° C., gradually increase the degree of pressure reduction from normal pressure to 50 hpa, and then inject only purified water into the system after the injection of the filtrate. Ethyl alcohol and water were distilled off until the odor of ethyl alcohol disappeared from the distillate. The final degree of vacuum was 20 hPa, and the container contents were in a dry state.
The evaporation residue had a yellowish brown viscosity, had a sweet and pleasant scent, and had a slightly bitter taste. There was no odor of ethyl alcohol.
This evaporation residue is 10.17 g, which corresponds to about 4.1% with respect to the raw cicada mushroom pressing residue.
To this evaporation residue, 760 g of purified water was added and stirred to dissolve. (About 1.3 wt%.)
The evaporation residue aqueous solution prepared as described above recovered 755 g of a distillate distilled from a normal pressure to a final reduced pressure of 20 hpa while maintaining the bath temperature at 45 ° C. using a rotary evaporator. Chishimazasa extract has a light yellow sweet and pleasant scent and has little bitter taste, and is suitable for use as a cosmetic or beverage formulation.
The physical properties of this Chishimasa extract are as follows.
Carbohydrate 0.7% or less Protein 0.06% or less Lipid 0.01% or less Ash 0.06% or less Water 99.17% or more

２）使用方法・手順
・被験者には通常の洗髪をしてもらう。
・洗髪後、実施例２−（２）の加圧熱水によるチシマザサ抽出物約１０ｍｌを、直接頭皮に摺りこむよう塗布した。洗髪しない日も同様に就寝前に塗布してもらった。この作業を1ヶ月継続してもらった。
３）判定
・目視にて判定

以上の結果のように、通院患者５名に、チシマザサ抽出物単独を１ヶ月塗布することで、全体に毛髪のボリュームが出てきた、毛髪が生えてきたなど、顕著な改善が認められ、本発明チシマザサ抽出物の養毛・育毛効果が認められた。 3. Hair growth and hair growth test <Human hair growth and hair growth test>
74-3 Edo, Ishie, Aomori City Medical Director Dr. Kenji Suzuki, Medical Director, Belsonte Suzuki Dermatology Department, with the consent of a patient at the hospital.
1) Subjects Table 3 shows the condition of the scalp before the test of three male subjects and two female subjects.

2) How to use / Procedures • Ask the subject to perform normal hair washing.
-After shampooing, about 10 ml of the extract of Chishimasa in pressurized hot water of Example 2- (2) was applied so as to be rubbed directly onto the scalp. The same day, they were applied before going to bed on the days when they did not wash their hair. This work was continued for one month.
3) Judgment-Judgment by visual inspection

As shown in the above results, the application of Chishimasa extract alone to 5 outpatients for 1 month showed significant improvements such as the appearance of hair volume and hair growth. The effect of hair restoration and hair restoration of the invention Chishimasa extract was recognized.

（１）から（７）を混合し、常温下で加熱溶解後、常法に従って弱酸性タイプのスキンケアローションを作製した。該スキンケアローションを３ヶ月保存したのち、塗布試験を行ったところ異臭も無く、しっとり感を備えた、良好なスキンケアローションであった。 4). Preparation of cosmetics The following is an example of blending cosmetics with the extract of Chishimasa obtained by the two methods.
<Prescription-1>
Lotion (slightly acidic skincare lotion)
The extract of Chishimasa using pressurized hot water in Example 2- (2) was used.

(1) to (7) were mixed, heated and dissolved at room temperature, and then a weakly acidic skin care lotion was prepared according to a conventional method. After the skin care lotion was stored for 3 months, an application test was conducted. The skin care lotion was free from a bad odor and had a moist feeling, and was a good skin care lotion.

（１）および（９）〜（１２）を80〜85℃に加熱溶解して水相液を調整し、これに予め（２）から（８）を溶解して80〜85℃の温度に加熱した油相液を混合して、常法に従ってスキントリートメントローション作製した。
得られたスキントリートメントローションを塗布した結果、特段の嫌味も無く、しっとり感があり、きめ細かな肌を与え、肌荒れに有効であった。 <Prescription-2>
Lotion (Skin Treatment Lotion)
The extract of Chishimasa using pressurized hot water in Example 2- (2) was used.

(1) and (9) to (12) are heated and dissolved at 80 to 85 ° C to prepare an aqueous phase liquid, and (2) to (8) are dissolved in advance and heated to a temperature of 80 to 85 ° C. The oil phase solution was mixed and a skin treatment lotion was prepared according to a conventional method.
As a result of applying the obtained skin treatment lotion, there was no special taste, moist feeling, fine skin and effective for rough skin.

（２）から（１２）を80〜85℃の温度に加熱溶解して油相液を調製し、これに予め（１）および（１３）から（１７）を溶解して80〜85℃の温度に加熱した水溶液を混合して常法に従って乳液を作製した。冷却後（１８）を混合してミルキーローションを得た。
得られたミルキーローションを室温下に３ヶ月間保存したところ変化は認められず、安定したものであり、塗布試験の結果、べとつきがなく、さっぱり感のあるミルキーローションであった。 <Prescription-3>
Milky lotion
The extract of Chishimasa by boiling under normal pressure in Example 2- (1) was used.

(2) to (12) are heated and dissolved at a temperature of 80 to 85 ° C. to prepare an oil phase liquid, and (1) and (13) to (17) are dissolved in advance to obtain a temperature of 80 to 85 ° C. The aqueous solution heated was mixed to prepare an emulsion according to a conventional method. After cooling, (18) was mixed to obtain a milky lotion.
When the obtained milky lotion was stored at room temperature for 3 months, no change was observed, and the milky lotion was stable, and as a result of the coating test, it was a milky lotion with a refreshing feeling without stickiness.

（１）から（５）を混合した水溶液に、予め（６）〜（１０）を溶解した油相液を均一に混合し、これに（１１）を加えて増粘させ、さらに（１２）〜（１４）を加えてジェル状の美容液を作製した。該ジェル状美容液を常温下で３ヶ月保存したのち、塗布試験を行ったところ安定であり、延びもあり、しっとり感を備えた、良好なジェル状美容液を得た。 <Prescription-4>
Cosmetic liquid (gel liquid)
The extract of Tichishimasa using a 20 wt% ethyl alcohol / water mixture of Example 2- (3) was used.

The oil phase solution in which (6) to (10) is dissolved in advance is uniformly mixed with the aqueous solution obtained by mixing (1) to (5), and (11) is added thereto to increase the viscosity. (14) was added to prepare a gel-like serum. The gel serum was stored at room temperature for 3 months, and then a coating test was conducted. As a result, a good gel serum was obtained that was stable, stretched and moist.

(2)から(10)を混合し、80〜85℃の温度下で加熱溶解後、油相液を調製し、これに予め(1)および(11)〜(14)を80〜85℃の温度下に加熱溶解して得た水溶液を常法に従って混合してモイスチャークリームを作製した。該モイスチャークリームを３ヶ月保存したところ品質の変化もなく安定であった。これについて塗布試験を行った結果、異臭も無く、エモリエント性の高い、しっとり感を備えた良好なモイスチャークリームを得た。 <Prescription-5>
Moisture cream The extract of Chishimasa in pressurized hot water of Example 2- (2) was used.

(2) to (10) are mixed, heated and dissolved at a temperature of 80 to 85 ° C., and then an oil phase liquid is prepared, and (1) and (11) to (14) are preliminarily added at 80 to 85 ° C. An aqueous solution obtained by heating and dissolving at a temperature was mixed according to a conventional method to prepare a moisture cream. The moisture cream was stored for 3 months and was stable with no change in quality. As a result of performing an application test on this, a good moisture cream having a moist feeling with high emollient and no odor was obtained.

5. Preparation of health functional food A prescription example of a health functional food to which the extract of tishima zasa with pressurized hot water of Example 2- (2) is added is shown below.
In addition, the Chishimazasa extract used the thing deodorized and decolored by filtering with activated carbon for drinks, and the tablet etc. used the powder which carried out the deodorizing and decoloring process by activated carbon, and was spray-dried.
<Prescription-6>
Drink
(1) to (4) were dissolved in (5) to prepare a drink. It is a beverage with a faint sweet fragrance unique to Chishimasa extract.

(１)〜(14)を混合したのち打錠機にかけ錠剤とした。処方−７は加齢による皮膚の老化の一つである肌の潤い、ハリを改善することが期待される。 <Prescription-7>
The tablet (1) was obtained by completely evaporating ethyl alcohol from the extract of Tichishimasa using a 20 wt% ethyl alcohol / water mixture of Example 2- (3), re-dissolving it in water, and then spray drying. is there.

After mixing (1) to (14), the mixture was put into a tableting machine to obtain tablets. Formula-7 is expected to improve the moisture and firmness of the skin, which is one of the aging of the skin due to aging.

(１)〜(11)を混合したのち散剤とした。 <Prescription-8>
Powder (1) used was the same spray-dried powder as used in Formula-7.

After mixing (1) to (11), a powder was prepared.

Claims (12)

The primary raw material that is a ginger of the genus Kumazasa (Akatsuki or Kumagusu) is shredded at room temperature, and the shredded material is compressed at room temperature and high pressure to extract a stock solution of medicinal substances in the protoplasm to obtain a secondary raw material, The secondary raw material is dried and pulverized, and the pulverized product is hydrolyzed with hot water to decompose polysaccharides, thereby extracting monosaccharides and oligosaccharides. Non-chemical two-step treatment of genus ginger. A method for producing an extract of the genus Kumazasa, wherein the active ingredient is extracted after hydration using the fresh leaves and stems of the genus Kumaza as a primary material and the Kumaza squeezed residue after squeezing the squeezed juice as a secondary material . A method for producing an extract of the genus Kumazasa, comprising adding water to the secondary raw material according to claim 2 and then performing heat treatment at 60 to 210 ° C in an open or closed container. A method for producing an extract of the genus Kumaza, which comprises immersing the secondary raw material according to claim 2 in an ethyl alcohol / water mixture at room temperature to extract an active ingredient. 5. The method for producing an extract of the genus Kumazasa according to claim 4, wherein the ethyl alcohol / water mixture is a mixture containing 50% by weight or less of ethyl alcohol. After adding water to the secondary raw material according to claim 2, after heat treatment at 60 to 210 ° C. in an open container or a closed container, it is fractionated without removing or removing solids, and as a distillate and a residual liquid. 4. The method for producing a Kumazasa extract according to claim 2 or 3, wherein the Kumazasa extract is obtained. The secondary raw material according to claim 2 is immersed in water containing 50% by weight or less of ethyl alcohol at room temperature, and then the liquid obtained by separating the solid content is heated to distill off the ethyl alcohol and water. The method for producing a Kumazasa extract according to claim 4 or 5. 8. The method for producing a Kumazasa extract according to claim 7, wherein after distilling off ethyl alcohol and water, the aqueous solution is substituted again with an aqueous solution, and fractionated at 70 ° C. or lower under reduced pressure. 9. An extract of the genus Kumazasa obtained by the production method according to claim 2, 3, 4, 5, 6, 7 or 8. A hair nourishing and hair restorer comprising the extract of the genus Kumazasa according to claim 9. A cosmetic comprising the extract of the genus Kumazasa according to claim 9. A health drink comprising the extract of the genus Kumazasa according to claim 9.