KR20190094913A - Composition for preventing hair loss or reinforcing scalp comprising natural extract - Google Patents
Composition for preventing hair loss or reinforcing scalp comprising natural extract Download PDFInfo
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- KR20190094913A KR20190094913A KR1020180014603A KR20180014603A KR20190094913A KR 20190094913 A KR20190094913 A KR 20190094913A KR 1020180014603 A KR1020180014603 A KR 1020180014603A KR 20180014603 A KR20180014603 A KR 20180014603A KR 20190094913 A KR20190094913 A KR 20190094913A
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Abstract
Description
본 발명은 천연 추출물을 유효성분으로 포함하는 탈모 방지 또는 두피 강화용 조성물에 관한 것이다.The present invention relates to a hair loss preventing or scalp strengthening composition comprising a natural extract as an active ingredient.
인체의 모발은 약 10만 내지 15만 개 정도이며, 각각의 모발은 서로 다른 주기를 가지며 성장기(anagen), 퇴행기(catagen), 휴지기(telogen)를 거쳐 성장, 탈락한다. 이러한 주기는 3-6년에 걸쳐 반복되는데, 그 결과 일일 평균 50 내지 100개의 모발이 정상적으로 탈락하게 된다. 일반적으로 탈모증이라 함은 이러한 주기 중에서 성장기의 모발 비율이 짧아지고, 퇴행기 또는 휴지기의 모발이 비율이 많아져 비정상적으로 모발이 탈락하는 숫자가 많아지는 것을 의미한다.The human hair is about 100,000 to 150,000 pieces, each hair has a different cycle and grow and drop out through the anagen, catagen, telogen. This cycle is repeated over three to six years, with the result that on average 50-100 hairs fall out normally. Generally, the term alopecia means that the hair growth rate of the growth phase is shortened among these cycles, and the number of hairs of the degenerative or resting phase increases, so that the number of abnormal hair dropouts increases.
탈모의 원인으로는 남성호르몬의 과다 분비, 지루성 두피, 스트레스, 비만, 과산화물, 세균 등에 의한 두피 기능 저하, 영양부족, 약물에 의한 부작용, 유전적 요인 등이 알려져 있다. 또한, 과도한 샴푸, 건조, 헤어스타일링 등으로 인한 두피 및 모발의 자극과 화학 세정 성분에 의한 두피의 천연 보습성분이 제거됨으로써 두피 및 모발이 손상을 받는 것으로 알려져 있다. 그러나, 현재까지 탈모에 관한 명확한 원인은 밝혀져 있지 않으며, 최근 들어 식생활의 변화, 사회환경 등에 의한 스트레스의 증가 등으로 탈모로 고민하는 인구가 늘어나고 있는 추세이고, 그 연령 또한 낮아지고 있으며, 여성의 탈모 인구도 늘어나고 있는 실정이다. The causes of hair loss are known to be excessive secretion of male hormones, seborrheic scalp, stress, obesity, peroxide, bacteria, reduced scalp function, malnutrition, side effects caused by drugs, genetic factors. In addition, it is known that the scalp and hair are damaged by irritation of the scalp and hair due to excessive shampooing, drying, hair styling, and the like, and the natural moisturizing component of the scalp by chemical cleaning ingredients is removed. However, to date, no clear cause of hair loss is known, and in recent years, a growing number of people are suffering from hair loss due to changes in diet and stress caused by social conditions. Population is also increasing.
이에 따라 탈모를 비롯한 각종 두피 및 모발의 이상 증상을 방지하고, 두피 및 모발의 상태를 개선시킬 수 있는 조성물에 대한 연구가 진행되어 왔다. 하지만, 기존의 두피 및 모발 관련 제품들은 주성분이 화학물질인 경우가 많아 두피에 부작용을 유발하는 경우가 많았으며, 두피 또는 모발 중 어느 하나에 중점적으로 작용하여 기능을 향상시키기 위한 것들이 대부분이었다. 따라서, 생체에 안전하고 사용이 간편할 뿐만 아니라, 제형 상으로도 안정성이 높으면서도 탈모 방지 및 발모 촉진을 포함한 모발 상태 개선뿐만 아니라, 비듬 방지 및 염증 완화 등의 두피 상태 개선이 가능한 종합적인 기능성 제품의 개발이 절실히 요구되고 있는 실정이다.Accordingly, research has been conducted on compositions capable of preventing abnormal symptoms of various scalp and hair, including hair loss, and improving the condition of the scalp and hair. However, the existing scalp and hair-related products are often the main ingredient is a chemical, causing many side effects on the scalp, mostly to improve the function by working on either the scalp or hair. Therefore, it is a comprehensive functional product that is not only safe for the living body and easy to use, but also has high stability in terms of formulation, and improves the hair condition including hair loss prevention and hair growth promotion, as well as anti-dandruff and inflammation reduction. The development of is urgently needed.
본 발명의 목적은 천연 추출물을 유효성분으로 포함하는 탈모 방지 또는 두피 강화용 조성물을 제공하는 데에 있다.It is an object of the present invention to provide a composition for preventing hair loss or strengthening the scalp comprising a natural extract as an active ingredient.
상기 목적을 달성하기 위하여, 본 발명은 조성물 총 100 중량부에 대하여, 대나무 추출물 55 내지 70 중량부, 녹차 추출물 1 내지 5 중량부, 어성초 추출물 1 내지 5 중량부, 다시마 추출물 1 내지 5 중량부, 검은콩 추출물 2 내지 6 중량부, 비오틴 2 내지 6 중량부, 실크아미노산 12 내지 16 중량부 및 에센셜 오일 0.1 내지 0.8 중량부를 유효성분으로 포함하는 탈모 방지 또는 두피 상태 개선을 위한 화장료 조성물, 약학 조성물 또는 건강식품 조성물을 제공한다.In order to achieve the above object, the present invention is based on a total of 100 parts by weight of the composition, 55 to 70 parts by weight of bamboo extract, 1 to 5 parts by weight of green tea extract, 1 to 5 parts by weight of Echochocho extract, 1 to 5 parts by weight of kelp extract, Cosmetic composition, pharmaceutical composition for preventing hair loss or improving scalp condition comprising 2 to 6 parts by weight of black bean extract, 2 to 6 parts by weight of biotin, 12 to 16 parts by weight of silkamino acid, and 0.1 to 0.8 parts by weight of essential oil as active ingredients. Provide a health food composition.
본 발명에 따른 녹차 추출물, 어성초 추출물, 다시마 추출물, 검은콩 추출물, 실크아미노산, 비오틴 및 에센셜 오일을 포함하는 천연 추출 조성물은 두피의 피지를 억제하고, 탈모를 방지하며, 두피 개선 및 모발 상태를 강화시키는 효과를 갖는다. 따라서, 상기와 같은 효과를 가지는 본 발명의 천연 추출 조성물은 탈모 방지 및 모발 상태 개선 뿐만 아니라, 피지 방지, 염증 완화 등 두피 상태의 개선이 가능한 종합적인 기능성 제품의 개발에 유용하게 활용될 수 있다.Natural extract composition comprising green tea extract, Echochocho extract, kelp extract, black soybean extract, silk amino acid, biotin and essential oil according to the present invention inhibits sebum of the scalp, prevents hair loss, improves scalp and enhances hair condition It has an effect to make. Therefore, the natural extract composition of the present invention having the above effect can be usefully used for the development of a comprehensive functional product capable of improving the scalp condition, such as preventing hair loss and improving hair condition, preventing sebum and inflammation.
도 1은 본 발명에 따른 천연 추출물을 유효성분으로 포함하는 탈모 방지 및 두피 강화용 제품의 제조 과정을 순차적으로 나타낸 것이다.
도 2는 상기 제품을 두피에 적용하여 제품 사용 전 후의 피지 개선 효과를 비교한 것이다.
도 3은 상기 제품을 샴푸 후 두피에 적용하여 사용 전 후의 모발 빠짐 정도를 비교한 것이다. Figure 1 shows in sequence the manufacturing process of the product for preventing hair loss and scalp enhancement comprising a natural extract according to the present invention as an active ingredient.
Figure 2 compares the sebum improvement effect before and after using the product by applying the product to the scalp.
Figure 3 compares the degree of hair loss before and after use by applying the product to the scalp after shampooing.
본 발명의 발명자들은 대나무 추출물을 기본 베이스로 하고, 녹차 추출물, 어성초 추출물, 다시마 추출물, 검은콩 추출물, 실크아미노산, 비오틴, 에센셜 오일, 비오틴 및 글리세린을 다양한 배합 비율로 첨가하여 가장 적합한 배합 비율을 선정하였으며, 상기 천연 추출 조성물이 두피의 피지를 억제하고 탈모 개선 효과를 나타냄을 확인하며 본 발명을 완성하였다.The inventors of the present invention, based on the bamboo extract, the addition of green tea extract, eochocho extract, kelp extract, black bean extract, silkamino acid, biotin, essential oils, biotin and glycerin in various blending ratios to select the most suitable blending ratio In addition, the natural extract composition was confirmed to exhibit the effect of inhibiting sebum of the scalp and improving hair loss, and completed the present invention.
녹차는 차나무의 어린잎을 따서 찌거나 열을 가해 효소의 작용을 억제시켜 말린 것으로 생리활성이 높은 폴리페놀류인 카테킨(catechin)과 탄닌(tannin)이 다량 함유되어 있을 뿐만 아니라 카페인, 비타민 및 많은 무기염류가 다량 함유되어 있어 전 세계에 걸쳐 널리 사용되고 있다. 우리가 호흡하는 산소는 에너지를 만드는 과정에서 활성산소를 생성하는데, 상기 활성산소는 세포의 여러 부위를 공격하므로 활성산소가 세포를 공격하기 전에 빨리 제거하는 것이 중요하다. 녹차 추출물은 우리 몸에 해로운 활성산소와 반응하여 과량의 활성산소를 제거하고, 항산화 작용을 하는 것으로 알려져 있다. 또한, 녹차의 주성분인 카테킨류는 성인병 예방과 후천성 면역결핍증, 바이러스와 충치 세균에 대해서도 강한 살균능력을 가지고 있어 충치예방 치약이나 소취제와 같은 화장품의 원료로 사용되고 있다. 또한, 커피 속의 카페인은 주성분이 클로로겐산으로 녹차 속에 있는 카테킨 등의 성분이 없기 때문에 체내에 바로 흡수되면서 강한 카페인의 활성과 함께 동맥경화나 심장질환을 일으키는데 반해 녹차의 카페인은 혈중 콜레스테롤을 저하시키는 카테킨과 같이 작용하기 때문에 상기와 같은 작용이 일어나지 않는다. 따라서 녹차는 항산화 효과를 증가시켜 모발의 성장을 유도할 수 있다.Green tea is steamed or steamed from young leaves of tea trees to suppress the action of enzymes, and is dried. It contains high amounts of physiologically active polyphenols, catechin and tannin, as well as caffeine, vitamins and many inorganic substances. It contains a large amount of salt and is widely used all over the world. The oxygen we breathe produces free radicals in the process of making energy, and it is important that the free radicals be removed quickly before they attack the cells, because they attack different parts of the cell. Green tea extract is known to react with free radicals that are harmful to our body to remove excess free radicals and to act as an antioxidant. In addition, catechins, the main component of green tea, have strong sterilizing ability against adult diseases, acquired immunodeficiency syndrome, viruses and tooth decay bacteria, and are used as raw materials for cosmetics such as tooth decay toothpaste and deodorant. In addition, since caffeine in coffee has chlorogenic acid as its main ingredient and there is no catechin in green tea, it is absorbed directly into the body and causes strong caffeine activity and causes arteriosclerosis and heart disease, whereas green tea caffeine is a catechin that lowers blood cholesterol and The same action does not occur because it works together. Therefore, green tea may increase the antioxidant effect and induce hair growth.
어성초에는 프라보노이드 물질 중 쿠에르치트린이 가장 풍부하게 함유되어 있다. 쿠에르치트린은 세포 혈관을 팽창시켜 이뇨작용을 하며, 변비 해소와 숙변 제거에 작용하고, 모세혈관의 강화로 혈압을 적정 수준으로 유지시켜 혈류를 개선시큰 효과를 가진다. 따라서, 어성초는 두피에 충분한 영양을 공급하고 두피에 쌓인 독소와 각종 노폐물을 제거하여 두피세포를 강화하고, 모발세포의 생성과 활성화를 도와 탈모개선에 도움을 줄 수 있다.Eochochocho contains the most abundant querchitrin among the flavonoids. Cuerchithrin dilates blood vessels to act as a diuretic, constipation and elimination of stool, and by strengthening capillaries, blood pressure is maintained at an appropriate level to improve blood flow. Therefore, Eoseongcho provides enough nutrition to the scalp and removes toxins and various wastes accumulated in the scalp to strengthen scalp cells, and helps hair loss by helping to generate and activate hair cells.
다시마는 갈조류에 속하는 해조류로서 다시마에 풍부하게 들어 있는 칼슘은 뼈 및 이를 구성하는 주요 요소이며, 체내에서 칼슘 활동을 증진시켜주는 마그네슘 역시 풍부하게 들어 있어 뼈 및 이를 강화시키는데 효과적이다. 다시마에는 머리카락을 구성하는 단백질, 비타민, 요오드, 아연, 유황, 칼슘, 철분 등이 다량 함유되어 있고, 모발 발육 촉진제의 역할을 하는 옥소라는 성분도 함유되어 있기 때문에 탈모 치료에도 효과적일 수 있다.Kelp is a seaweed belonging to the brown algae, calcium is abundant in the kelp is a major component of bone and its composition, and also contains abundant magnesium to enhance calcium activity in the body is effective in strengthening bone and it. Kelp contains protein, vitamins, iodine, zinc, sulfur, calcium, iron, etc., which make up hair, and oxo, a component that promotes hair growth, may also be effective in treating hair loss.
검은콩은 양질의 단백질은 물론 각종 비타민 뿐만 아니라 모발의 주요 구성성분이라 할 수 있는 시스테인, 식물성 에스트로겐, 이소플라본 등이 함유되어 있어 모근의 상피세포에 영양분을 공급하고 모근을 자극하여 세포의 활성을 유도할 수 있다.Black soybean contains not only high-quality protein but also various vitamins as well as cysteine, phytoestrogens, and isoflavones, which are the main constituents of hair. Can be induced.
실크아미노산은 누에고치에서 얻어지는 천연 아미노산의 하나로, 8가지의 필수아미노산과 10가지의 비필수아미노산으로 구성되는데, 이들 아미노산을 살펴보면, 글리신(Glycine), 알라닌(Alanine), 세린(Serine), 티로신(Tyrosine), 발린(Valine), 아스파라긴산(Asparagine acid), 글루타민산(Glutamine acid), 트레오닌(Threonine), 이소루신(Isoleucine), 페닐알라닌(Phenylalanine), 로이신(Leucine), 아르기닌(Arginine), 라이신(Lysine), 시스틴(Cysteine), 프롤린(Proline), 히스티딘(Histidine), 트립토판(Tryptophan), 메티오닌(Methionine)으로 구성된다. 실크아미노산은 피부 재생, 지혈 및 해열 효과를 가지는 것으로 알려져 있고, 피부에 흡수가 잘 되어 두피와 손상된 모발을 회복시키는데 도움을 줄 수 있다.Silkamino acid is one of the natural amino acids obtained from cocoon, and consists of 8 essential amino acids and 10 non-essential amino acids.These amino acids include glycine, alanine, serine, tyrosine ( Tyrosine, Valine, Asparagine acid, Glutamine acid, Threonine, Thsoleon, Isoleucine, Phenylalanine, Leucine, Arginine, Lysine Cysteine, Proline, Histidine, Tryptophan, Methionine. Silkamino acids are known to have skin regeneration, hemostatic and antipyretic effects, and are well absorbed by the skin, which can help to restore the scalp and damaged hair.
비오틴은 비타민 B 복합체의 일부인 수용성 비타민으로 몸의 대사, 신경, 소화 및 심혈관 기능에 필요한 주요 영양소이다. 비오틴은 지방산, 아미노산 및 포도당의 신진 대사에 필요한 신체의 보효소 역할을 하고, 단백질 대사를 도와 두피 개선에 도움을 주고 모낭조직을 자극해 새로운 모발 생성을 촉진시킬 수 있다. Biotin is a water-soluble vitamin that is part of the vitamin B complex and is a key nutrient for the body's metabolism, nerves, digestion, and cardiovascular function. Biotin acts as the body's coenzyme for the metabolism of fatty acids, amino acids and glucose, helps metabolize proteins, improves the scalp and stimulates hair follicle tissue to promote new hair production.
페퍼민트 오일에 함유되어 있는 멘톨 성분은 항균 및 쿨링 효과로 가져 두피의 열을 낮추어 줄 수 있고, 티트리 오일은 피지 조절 효과가 있어 지루성 두피염을 예방할 수 있으며, 로즈마리 오일은 두피의 혈액순환을 촉진하여 모낭세포를 활성화하고 모발 생성을 촉진시킬 수 있다.Menthol contained in peppermint oil can reduce scalp heat with antibacterial and cooling effect, tea tree oil has sebum control effect to prevent seborrheic scalp infection, and rosemary oil promotes blood circulation of scalp This can activate hair follicle cells and promote hair production.
본 발명은 조성물 총 100 중량부에 대하여, 대나무 추출물 55 내지 70 중량부, 녹차 추출물 1 내지 5 중량부, 어성초 추출물 1 내지 5 중량부, 다시마 추출물 1 내지 5 중량부, 검은콩 추출물 2 내지 6 중량부, 비오틴 2 내지 6 중량부, 실크아미노산 12 내지 16 중량부 및 에센셜 오일 0.1 내지 0.8 중량부를 유효성분으로 포함하는 탈모 방지 또는 두피 상태 개선용 화장료 조성물을 제공한다.The present invention is based on 100 parts by weight of the total composition, 55 to 70 parts by weight of bamboo extract, 1 to 5 parts by weight of green tea extract, 1 to 5 parts by weight of Echochocho extract, 1 to 5 parts by weight of kelp extract, 2 to 6 parts by weight of black bean extract It provides a cosmetic composition for preventing hair loss or improving the scalp state, comprising 2 to 6 parts by weight of biotin, 12 to 16 parts by weight of silkamino acid, and 0.1 to 0.8 parts by weight of essential oil as an active ingredient.
상기 에센셜 오일은 페퍼민트 오일, 티트리 오일, 로즈마리 오일 및 림스 오일로 이루어진 군에서 선택된 어느 하나 이상일 수 있으나, 이에 제한되는 것은 아님을 명시한다.The essential oil may be any one or more selected from the group consisting of peppermint oil, tea tree oil, rosemary oil, and rims oil, but is not limited thereto.
상기 페퍼민트 오일, 티트리 오일, 로즈마리 오일 및 림스 오일은 3:3:3:1의 중량비로 포함될 수 있으나, 이에 제한되는 것은 아님을 명시한다.The peppermint oil, tea tree oil, rosemary oil and rims oil may be included in a weight ratio of 3: 3: 3: 1, but are not limited thereto.
상기 조성물은 보습제 및 가용화제를 더 포함할 수 있고, 상기 보습제는 글리세린, 부틸렌글라이콜, 디프로필렌글리콜, 소듐하이알루로네이트, 베타인, 트레할로스, 프로필렌글라이콜, 젖산나트륨, 솔비톨 및 스쿠알렌으로 이루어진 군에서 선택될 수 있으며, 상기 가용화제는 올리브 리퀴드, HCO60, HCO40, 솔루빌라이저, 폴리소르베이트 및 솔루졸로 이루어진 군에서 선택될일 수 있으나, 이에 제한되는 것은 아님을 명시한다. The composition may further comprise a moisturizer and a solubilizer, the moisturizer being glycerin, butylene glycol, dipropylene glycol, sodium hyaluronate, betaine, trehalose, propylene glycol, sodium lactate, sorbitol and squalene It may be selected from the group consisting of, the solubilizer may be selected from the group consisting of olive liquid, HCO60, HCO40, solubilizer, polysorbate and solusol, but is not limited thereto.
상기 보습제는 글리세린, 상기 가용화제는 올리브 리퀴드가 바람직할 수 있다.The moisturizing agent is glycerin, the solubilizer may be preferably olive liquid.
상기 조성물은 탈모 방지, 피지 억제 또는 모발 상태를 개선시킬 수 있다.The composition can prevent hair loss, inhibit sebum or improve hair condition.
상기 조성물은 헤어토닉, 헤어컨디셔너, 헤어에센스, 헤어로션, 헤어영양로션, 헤어샴푸, 헤어린스, 헤어트리트먼트, 헤어크림, 헤어영양크림, 헤어모이스처크림, 헤어맛사지크림, 헤어왁스, 헤어에어로졸, 헤어팩, 헤어영양팩, 헤어비누, 헤어클렌징폼, 머릿기름, 모발건조제, 모발보존처리제, 모발염색제, 모발용 웨이브제, 모발탈색제, 헤어겔, 헤어글레이즈, 헤어드레싱어, 헤어래커, 헤어모이스처라이저, 헤어무스 및 헤어스프레이로 구성된 군으로부터 선택된 제형일 수 있으나, 이에 제한되는 것은 아님을 명시한다.The composition includes hair tonic, hair conditioner, hair essence, hair lotion, hair nutrition lotion, hair shampoo, hair rinse, hair treatment, hair cream, hair nourishment cream, hair moisturizer cream, hair massage cream, hair wax, hair aerosol, Hair Pack, Hair Nutrition Pack, Hair Soap, Hair Cleansing Foam, Hair Oil, Hair Dryer, Hair Preservative, Hair Dye, Hair Wave Agent, Hair Bleach, Hair Gel, Hair Glaze, Hair Dresser, Hair Lacquer, Hair Moisturizer, Hair It may be, but is not limited to, a formulation selected from the group consisting of mousse and hairspray.
본 발명의 조성물이 화장료 조성물인 경우, 상기 화장료 조성물은 상기 유효성분 외에 안정화제, 용해화제, 비타민, 안료 및 향료와 같은 통상적인 보조제, 그리고 담체를 포함할 수 있다. 또한, 상기 화장료 조성물은 그 효과를 증진시키기 위해 피부 흡수 촉진제를 추가로 포함할 수 있다.When the composition of the present invention is a cosmetic composition, the cosmetic composition may include, in addition to the active ingredient, conventional auxiliaries such as stabilizers, solubilizers, vitamins, pigments and flavors, and carriers. In addition, the cosmetic composition may further include a skin absorption enhancer to enhance the effect.
상기 화장료 조성물의 제형은 당업계에서 통상적으로 제조되는 어떠한 제형으로도 제조될 수 있으며, 예를 들어, 화장료 조성물은 화장수, 유액, 스킨, 토너, 로션, 에센스, 선 스크린, 크림, 메이크업 베이스, 파운데이션, 파우더, 팩, 젤, 샴푸, 린스, 스프레이, 메이크업 제거제 및 세정제 등으로 제형화 될 수 있으나, 이에 한정되는 것은 아님을 명시한다.The formulation of the cosmetic composition may be prepared in any formulation conventionally prepared in the art, for example, the cosmetic composition may be a lotion, latex, skin, toner, lotion, essence, sunscreen, cream, makeup base, foundation , Powders, packs, gels, shampoos, rinses, sprays, makeup removers and cleansers, etc., but are not limited thereto.
상기 제형이 페이스트, 크림 또는 겔인 경우에는 담체 성분으로서 동물성유, 식물성유, 왁스, 파라핀, 전분, 트라칸트, 셀룰로오스 유도체, 폴리에틸렌 글리콜, 실리콘, 벤토나이트, 실리카, 탈크 또는 산화아연 등이 이용될 수 있다.When the formulation is a paste, cream or gel, animal oil, vegetable oil, wax, paraffin, starch, tracant, cellulose derivative, polyethylene glycol, silicone, bentonite, silica, talc or zinc oxide may be used as a carrier component. .
상기 제형이 파우더 또는 스프레이인 경우에는 담체 성분으로서 락토스, 탈크, 실리카, 알루미늄 히드록시드, 칼슘 실리케이트 또는 폴리아미드 파우더가 이용될 수 있고, 특히 스프레이인 경우에는 추가적으로 클로로플루오로히드로카본, 프로판/부탄 또는 디메틸 에테르와 같은 추진체를 포함할 수 있다.If the formulation is a powder or a spray, lactose, talc, silica, aluminum hydroxide, calcium silicate or polyamide powder may be used, in particular in the case of a spray additionally chlorofluorohydrocarbon, propane / butane Or propellants such as dimethyl ether.
상기 제형이 용액 또는 유탁액인 경우에는 담체 성분으로서 용매, 용해화제 또는 유탁화제가 이용되고, 예컨대 물, 에탄올, 이소프로판올, 에틸 카보네이트, 에틸 아세테이트, 벤질 알코올, 벤질 벤조에이트, 프로필렌 글리콜, 1,3-부틸글리콜 오일, 글리세롤 지방족 에스테르, 폴리에틸렌 글리콜 또는 소르비탄의 지방산 에스테르가 있다.If the formulation is a solution or emulsion, solvents, solubilizers or emulsions are used as carrier components, such as water, ethanol, isopropanol, ethyl carbonate, ethyl acetate, benzyl alcohol, benzyl benzoate, propylene glycol, 1,3 Fatty acid esters of butylglycol oil, glycerol aliphatic ester, polyethylene glycol or sorbitan.
상기 제형이 현탁액인 경우에는 담체 성분으로서 물, 에탄올 또는 프로필렌 글리콜과 같은 액상의 희석제, 에톡실화 이소스테아릴 알코올, 폴리옥시에틸렌 소르비톨 에스테르 및 폴리옥시에틸렌 소르비탄 에스테르와 같은 현탁제, 미소결정성 셀룰로오스, 알루미늄 메타히드록시드, 벤토나이트, 아가 또는 트라칸트 등이 이용될 수 있다.If the formulation is a suspension, liquid carrier diluents such as water, ethanol or propylene glycol, suspensions such as ethoxylated isostearyl alcohol, polyoxyethylene sorbitol esters and polyoxyethylene sorbitan esters, microcrystalline cellulose , Aluminum metahydroxy, bentonite, agar or tracant and the like can be used.
또한, 본 발명은 조성물 총 100 중량부에 대하여, 대나무 추출물 55 내지 70 중량부, 녹차 추출물 1 내지 5 중량부, 어성초 추출물 1 내지 5 중량부, 다시마 추출물 1 내지 5 중량부, 검은콩 추출물 2 내지 6 중량부, 비오틴 2 내지 6 중량부, 실크아미노산 12 내지 16 중량부 및 에센셜 오일 0.1 내지 0.8 중량부를 유효성분으로 포함하는 탈모 방지 또는 두피 상태 개선용 약학 조성물을 제공한다.In addition, the present invention with respect to 100 parts by weight of the total composition, 55 to 70 parts by weight of bamboo extract, 1 to 5 parts by weight of green tea extract, 1 to 5 parts by weight of Echochocho extract, 1 to 5 parts by weight of kelp extract, 2 to black soybean extract It provides a pharmaceutical composition for preventing hair loss or improving scalp condition comprising 6 parts by weight, 2 to 6 parts by weight of biotin, 12 to 16 parts by weight of silkamino acid, and 0.1 to 0.8 parts by weight of essential oil as an active ingredient.
상기 에센셜 오일은 페퍼민트 오일, 티트리 오일, 로즈마리 오일 및 림스 오일로 이루어진 군에서 선택된 어느 하나 이상일 수 있으나, 이에 제한되는 것은 아님을 명시한다.The essential oil may be any one or more selected from the group consisting of peppermint oil, tea tree oil, rosemary oil, and rims oil, but is not limited thereto.
본 발명의 조성물이 약학 조성물인 경우, 투여를 위하여, 상기 기재한 유효성분 이외에 약학적으로 허용 가능한 담체, 부형제 또는 희석제를 포함할 수 있다. 상기 담체, 부형제 및 희석제로는 락토오스, 덱스트로오스, 수크로오스, 소르비톨, 만니톨, 자일리톨, 에리스리톨, 말티톨, 전분, 아카시아 고무, 알지네이트, 젤라틴, 칼슘 포스페이트, 칼슘 실리케이트, 셀룰로오스, 메틸 셀룰로오스, 미정질 셀룰로오스, 폴리비닐피롤리돈, 물, 메틸히드록시벤조에이트, 프로필히드록시벤조에이트, 탈크, 마그네슘 스테아레이트 및 광물유를 들 수 있다.When the composition of the present invention is a pharmaceutical composition, for administration, it may include a pharmaceutically acceptable carrier, excipient or diluent in addition to the active ingredient described above. The carrier, excipient and diluent may include lactose, dextrose, sucrose, sorbitol, mannitol, xylitol, erythritol, maltitol, starch, acacia rubber, alginate, gelatin, calcium phosphate, calcium silicate, cellulose, methyl cellulose, microcrystalline cellulose, Polyvinylpyrrolidone, water, methylhydroxybenzoate, propylhydroxybenzoate, talc, magnesium stearate and mineral oil.
본 발명의 약학 조성물은 각각 통상의 방법에 따라 산제, 과립제, 정제, 캡슐제, 현탁액, 에멀젼, 시럽, 에어로졸 등의 경구형 제형, 외용제, 좌제 또는 멸균 주사용액의 형태로 제형화하여 사용할 수 있다. 상세하게는 제형화할 경우 통상 사용하는 충진제, 중량제, 결합제, 습윤제, 붕해제, 계면활성제 등의 희석제 또는 부형제를 사용하여 조제될 수 있다. 경구투여를 위한 고형 제제로는 정제, 환제, 산제, 과립제, 캡슐제 등을 포함하나, 이에 한정되는 것은 아니다. 이러한 고형 제제는 상기 유효성분 외에 적어도 하나 이상의 부형제, 예를 들면, 전분, 칼슘 카보네이트, 수크로오스, 락토오스, 젤라틴 등을 섞어 조제될 수 있다. 또한, 단순한 부형제 이외에 마그네슘 스테아레이트, 탈크 같은 윤활제들도 사용될 수 있다. 경구를 위한 액상물, 리퀴드 파라핀 이외에 여러 가지 부형제, 예를 들면 습윤제, 감미제, 방향제, 보존제 등을 첨가하여 조제될 수 있다. 비경구 투여를 위한 제제는 멸균된 수용액, 비수성 용제, 현탁제, 유제, 동결건조 제제 및 과제를 포함한다. 비수성 용제 및 현탁제로는 프로필렌글리콜, 폴리에틸렌글리콜, 올리브 오일과 같은 식물성 오일, 에틸올레이트와 같은 주사 가능한 에스테르 등이 사용될 수 있다. 좌제의 기제로는 위텝솔, 마크로솔, 트윈 61, 카카오지, 라우린지, 글리세로젤라틴 등이 사용될 수 있다.The pharmaceutical compositions of the present invention may be formulated in the form of powders, granules, tablets, capsules, suspensions, emulsions, syrups, aerosols, oral formulations, external preparations, suppositories, or sterile injectable solutions according to conventional methods. . In detail, when formulated, it may be prepared by using diluents or excipients such as fillers, weights, binders, wetting agents, disintegrating agents, and surfactants which are commonly used. Solid preparations for oral administration include, but are not limited to, tablets, pills, powders, granules, capsules, and the like. Such solid preparations may be prepared by mixing at least one excipient such as starch, calcium carbonate, sucrose, lactose, gelatin and the like in addition to the active ingredient. In addition to simple excipients, lubricants such as magnesium stearate, talc can also be used. It may be prepared by adding various excipients such as humectants, sweeteners, fragrances, preservatives and the like in addition to liquid oral liquids or liquid paraffin for oral use. Formulations for parenteral administration include sterile aqueous solutions, non-aqueous solvents, suspensions, emulsions, lyophilized formulations and tasks. As the non-aqueous solvent and suspending agent, propylene glycol, polyethylene glycol, vegetable oils such as olive oil, injectable esters such as ethyl oleate, and the like can be used. As the base of the suppository, utopsol, macrosol, tween 61, cacao butter, laurin butter, glycerogelatin and the like can be used.
본 발명의 약학 조성물의 적합한 투여량은 환자의 상태 및 체중, 질병의 정도, 약물형태, 시간에 따라 다르지만, 당 업자에 의해 적절하게 선택될 수 있는 바, 상기 조성물의 일일 투여량은 바람직하게는 0.001 mg/kg 내지 50 mg/kg이며, 필요에 따라 일일 1회 내지 수회로 나누어 투여할 수 있다.Suitable dosages of the pharmaceutical compositions of the present invention vary depending on the condition and weight of the patient, the severity of the disease, the form of the drug, and the time, but can be appropriately selected by those skilled in the art, and therefore the daily dosage of the composition is preferably It is 0.001 mg / kg to 50 mg / kg, it can be administered once or divided into several times as needed.
또한, 본 발명은 조성물 총 100 중량부에 대하여, 대나무 추출물 55 내지 70 중량부, 녹차 추출물 1 내지 5 중량부, 어성초 추출물 1 내지 5 중량부, 다시마 추출물 1 내지 5 중량부, 검은콩 추출물 2 내지 6 중량부, 비오틴 2 내지 6 중량부, 실크아미노산 12 내지 16 중량부 및 에센셜 오일 0.1 내지 0.8 중량부를 유효성분으로 포함하는 탈모 방지 또는 두피 상태 개선용 건강식품 조성물을 제공한다.In addition, the present invention with respect to 100 parts by weight of the total composition, 55 to 70 parts by weight of bamboo extract, 1 to 5 parts by weight of green tea extract, 1 to 5 parts by weight of Echochocho extract, 1 to 5 parts by weight of kelp extract, 2 to black soybean extract It provides a health food composition for preventing hair loss or improving the scalp condition comprising 6 parts by weight, 2 to 6 parts by weight of biotin, 12 to 16 parts by weight of silkamino acid, and 0.1 to 0.8 parts by weight of essential oil as an active ingredient.
상기 에센셜 오일은 페퍼민트 오일, 티트리 오일, 로즈마리 오일 및 림스 오일로 이루어진 군에서 선택된 어느 하나 이상일 수 있으나, 이에 제한되는 것은 아님을 명시한다.The essential oil may be any one or more selected from the group consisting of peppermint oil, tea tree oil, rosemary oil, and rims oil, but is not limited thereto.
본 발명의 조성물이 건강식품 조성물인 경우, 여러 가지 영양제, 비타민, 광물(전해질), 합성 풍미제 및 천연 풍미제 등의 풍미제, 착색제 및 중진제(치즈, 초콜릿 등), 펙트산 및 그의 염, 알긴산 및 그의 염, 유기산, 보호성 콜로이드 증점제, pH 조절제, 안정화제, 방부제, 글리세린, 알코올, 탄산음료에 사용되는 탄산화제 등을 함유할 수 있다. 그 밖에 천연 과일 주스, 합성 과일 주스 및 야채 음료의 제조를 위한 과육을 함유할 수 있다. 이러한 성분은 독립적으로 또는 조합하여 사용할 수 있다. 또한, 건강식품 조성물은 육류, 소세지, 빵, 초콜릿, 캔디류, 스넥류, 과자류, 피자, 라면, 껌류, 아이스크림류, 스프, 음료수, 차, 기능수, 드링크제, 알코올 및 비타민 복합제 중 어느 하나의 형태일 수 있다.When the composition of the present invention is a health food composition, flavors such as various nutrients, vitamins, minerals (electrolytes), synthetic flavors and natural flavors, coloring and neutralizing agents (such as cheese, chocolate), pectic acid and salts thereof , Alginic acid and salts thereof, organic acids, protective colloidal thickeners, pH adjusters, stabilizers, preservatives, glycerin, alcohols, carbonation agents used in carbonated drinks and the like. Others may contain pulp for the production of natural fruit juices, synthetic fruit juices and vegetable drinks. These components can be used independently or in combination. In addition, the health food composition may be in the form of any one of meat, sausage, bread, chocolate, candy, snacks, confectionary, pizza, ramen, gum, ice cream, soup, beverage, tea, functional water, drink, alcohol and vitamin complex Can be.
또한, 상기 건강식품 조성물은 식품첨가물을 추가로 포함할 수 있으며, 식품첨가물로서의 적합 여부는 다른 규정이 없는 한 식품의약품안전처에 승인된 식품첨가물공전의 총칙 및 일반 시험법 등에 따라 해당 품목에 관한 규격 및 기준에 의하여 판정한다.In addition, the health food composition may further include a food additive, and the suitability as a food additive is related to the item according to the General Regulations and General Test Law of the Food Additives Code approved by the Ministry of Food and Drug Safety unless otherwise specified. Judging by the standards and standards.
상기 식품첨가물공전에 수재된 품목으로 예를 들어, 케톤류, 글리신, 구연산 칼륨, 니코틴산, 계피산 등의 화학적 합성품, 감색소, 감초추출물, 결정셀룰로오스, 고랭색소, 구아검 등의 천연첨가물, L-글루타민산나트륨 제제, 면류 첨가 알칼리제, 보존료제제, 타르색소 제제 등의 혼합 제제류 등을 들 수 있다.Examples of the items added to the food additives, chemical synthetic products such as ketones, glycine, potassium citrate, nicotinic acid, cinnamon acid, navy dye, licorice extract, natural additives such as crystalline cellulose, high quench pigment, guar gum, L-glutamic acid Mixed preparations, such as a sodium preparation, a noodles addition alkali agent, a preservative preparation, and a tar pigment preparation, etc. are mentioned.
이때, 건강식품 조성물을 제조하는 과정에서 식품에 첨가되는 본 발명에 따른 조성물은 필요에 따라 그 함량을 적절히 가감할 수 있다.At this time, the composition according to the present invention to be added to food in the process of preparing a health food composition can be appropriately added or reduced the content as needed.
이하에서는 실시예를 통하여 본 발명을 더욱 상세히 설명하고자 한다. 이들 실시예는 오로지 본 발명을 보다 구체적으로 설명하기 위한 것으로, 본 발명의 요지에 따라 본 발명의 범위가 이들 실시예에 의해 제한되지 않는다는 것은 당업계에서 통상의 지식을 가진 자에 있어서 자명할 것이다.Hereinafter, the present invention will be described in more detail with reference to Examples. These examples are only for illustrating the present invention in more detail, it will be apparent to those skilled in the art that the scope of the present invention is not limited by these examples in accordance with the gist of the present invention. .
실시예Example 1: 천연 추출물을 함유하는 조성물 제조 1: Preparation of a composition containing a natural extract
도 1은 천연 추출물을 함유하는 조성물의 제조방법을 순차적으로 나타낸 것이다. 먼저 녹차, 어성초, 다시마, 검은콩을 각 250 g 씩 정량하고, 오쿠 추출기를 이용하여 물 500 mL에서 6시간 동안 끓여 추출물을 추출하였다. 각 추출물은 진공 감압 농축기를 이용하여 150 mL의 부피로 농축하였다. 농축액은 불순물을 제거하기 위해 여과지로 여과하였다. 0.4 g의 비오틴을 정량하여 50 mL의 메스플라스크에 첨가하고 용해한 다음 상등액을 사용하였다. 제품의 향과 성능을 향상시키기 위해, 에센셜 오일로 페퍼민트 오일, 티트리 오일, 로즈마리 오일을 사용하였다. 대나무 추출물을 기본 베이스로 하고, 보습제로서 글리세린을 사용하였으며, 수분층과 유분층을 혼합시키기 위해, 가용화제로 올리브 리퀴드를 사용하였다. 조성물의 흡수를 돕기 위해 실크아미노산을 사용하였다. 조성물은 용기에 담아 제품으로 완성시켰다.Figure 1 shows in sequence the method for producing a composition containing a natural extract. First, green tea, eoseongcho, kelp and black soybeans were quantified by 250 g each, and extracted by boiling for 6 hours in 500 mL of water using an Oku extractor. Each extract was concentrated to a volume of 150 mL using a vacuum depressurizer. The concentrate was filtered through filter paper to remove impurities. 0.4 g of biotin was quantified and added to a 50 mL volumetric flask, dissolved, and the supernatant was used. To enhance the fragrance and performance of the product, peppermint oil, tea tree oil and rosemary oil were used as essential oils. Based on bamboo extract, glycerin was used as a moisturizer, and olive liquid was used as a solubilizer to mix the water layer and the oil layer. Silkamino acids were used to aid in the absorption of the composition. The composition was placed in a container to complete the product.
상기 각 성분의 함량을 다르게 배합하여 제품을 제조하였으며, 최적의 배합 비를 확정하기 위해, 제품을 평가 및 분석하였다.The product was prepared by differently blending the content of each component, and the product was evaluated and analyzed to determine the optimum blending ratio.
실시예 2: 각 성분의 배합 비에 따른 제품의 효과 분석Example 2 Analysis of Effect of Product on Mixing Ratio of Each Component
상기 실시예 1의 성분들을 이용하여 하기 표 1과 같이, 다양한 배합 비율로 4개의 제품을 완성하였다. Using the components of Example 1, as shown in Table 1 below, four products were completed at various mixing ratios.
각 제품을 두피에 적용한 결과, 청량감은 3 > 1 > 4 > 2의 순서를 보였다. 오일에 의한 청량감 비교 시, 1번 제품과 3번 제품에 같은 양의 오일이 첨가되었으나, 가용화제 및 첨가물이 더 많이 함유되어 있는 1번 제품의 청량감이 적었다.As a result of applying each product to the scalp, the refreshment was in the order of 3> 1> 4> 2. Compared with oil refreshment, the same amount of oil was added to product 1 and 3, but product 1, which contained more solubilizers and additives, was less.
사용감은 4 > 3 > 2 > 1의 순서를 보였고, 기본 베이스인 대나무 추출물의 함량이 많을수록 끈적임이 덜해 사용 시 거부감이 적었다.The feeling of use was in the order of 4> 3> 2> 1, and the higher the content of the bamboo extract, which is the basic base, the less stickiness, so there was less rejection.
두피 피지에서의 효과는 3 > 2 > 4 > 1의 순서를 보였다. 첨가물의 양이 많은 경우, 사용감이 무거웠고 오히려 두피의 피지가 더 발생하였다. The effect on scalp sebum was 3> 2> 4> 1. When the amount of the additive was large, the feeling was heavy and more sebum of the scalp occurred.
상기 결과를 종합하였을 때, 3번 제품의 배합 비가 가장 적합한 것으로 판단하였다.Based on the above results, it was determined that the compounding ratio of the third product was most suitable.
그러나 상기 제품은 두피에 빠르게 흡수되지 않은 문제점이 있어 제품의 흡수를 개선하기 위해, 실크아미노산을 첨가하였으며, 비듬 증상 및 건성 두피를 개선하기 위해, 림스 오일을 첨가하였다. However, the product has a problem that the product is not rapidly absorbed into the scalp, to improve the absorption of the product, silk amino acid was added, and to improve dandruff symptoms and dry scalp, rims oil was added.
상기 실시예 1의 성분들 및 실크아미노산, 림스 오일을 이용하여 하기 표 2와 같이, 다양한 배합 비율로 4개의 제품을 완성하였다. Using the components of Example 1 and silk amino acid, rims oil, as shown in Table 2 below, four products were completed at various mixing ratios.
상기 제품들에서도 마찬가지로 3번 제품의 배합 비가 가장 적합한 것으로 판단되어 3번의 배합 비율로 제품을 완성하였다.In the above products, the formulation ratio of the third product was determined to be the most suitable, thus completing the product at the three formulation ratios.
각 제품을 두피에 30일 동안 적용하여 피지 개선 효과를 분석하였다. 그 결과, 도 2와 같이 제품 사용 후 면봉에 묻어나오는 피지의 양이 감소하는 것을 확인할 수 있었다. Each product was applied to the scalp for 30 days to analyze sebum improvement effect. As a result, it was confirmed that the amount of sebum buried in the cotton swab after using the product as shown in FIG.
다음으로 샴푸를 하고 제품을 두피에 30일 동안 적용하여 모발이 빠지는 정도를 분석한 결과, 도 3과 같이 제품 사용 후 모발의 빠짐이 감소하는 것을 확인할 수 있었다. 두피 진정으로 인한 모발 강화 효과를 뿐만 아니라 여러 번의 임상실험을 통하여 부작용이 발견되지 않았다. Next, after shampooing and applying the product to the scalp for 30 days to analyze the degree of hair fall, it was confirmed that the fall of the hair after using the product as shown in FIG. In addition to the hair-strengthening effects of sedation of the scalp, no side effects were found through several clinical trials.
이상으로 본 발명의 특정한 부분을 상세히 기술한 바, 당업계의 통상의 지식을 가진 자에게 있어서 이러한 구체적인 기술은 단지 바람직한 구현 예일 뿐이며, 이에 본 발명의 범위가 제한되는 것이 아닌 점은 명백하다. 따라서, 본 발명의 실질적인 범위는 첨부된 청구항과 그의 등가물에 의하여 정의된다고 할 것이다.As described above in detail certain parts of the present invention, it is apparent to those skilled in the art that these specific descriptions are merely preferred embodiments, and the scope of the present invention is not limited thereto. Thus, the substantial scope of the present invention will be defined by the appended claims and equivalents thereof.
본 발명의 범위는 후술하는 특허청구범위에 의하여 나타내어지며, 특허청구범위의 의미 및 범위 그리고 그 균등 개념으로부터 도출되는 모든 변경 또는 변형된 형태가 본 발명의 범위에 포함되는 것으로 해석되어야 한다.The scope of the present invention is represented by the following claims, and it should be construed that all changes or modifications derived from the meaning and scope of the claims and their equivalents are included in the scope of the present invention.
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Cited By (6)
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KR102195880B1 (en) * | 2020-09-01 | 2020-12-29 | 주식회사 한미양행 | Composition for hair loss prevention or hair growth promotion containing cricket and Tenebrio molitor treated with high-pressure by steaming process and enzyme-decomposed |
KR102209294B1 (en) * | 2020-05-19 | 2021-02-01 | 주식회사 엑소코바이오 | Freeze-dried formulation of exosomes derived from stem cell and composition comprising the same for promoting hair growth or preventing hair loss |
KR102363835B1 (en) | 2021-08-10 | 2022-02-16 | 주식회사 에이치엔비웰 | Cosmetic composition for hair and scalp containing fermented natural plant extracts complex |
KR102418114B1 (en) | 2022-02-24 | 2022-07-07 | 주식회사 에이치엔비웰 | Cosmetic composition for enhancing hair volume and scalp condition containing natural complex extract |
KR20220118679A (en) * | 2021-02-19 | 2022-08-26 | 대경대학교 산학협력단 | Hair Essence Composition Comprising Jujube Extract and Manufacturing Method thereof |
KR102488287B1 (en) * | 2022-01-03 | 2023-01-13 | 주식회사 마미야 | Health food containing biotin |
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KR101800956B1 (en) | 2016-04-04 | 2018-01-25 | 주식회사 와이제이테크 | Composition for preventing hair loss and stimulating hair growth comprising phytosphingosine and yeast extract as active ingredients |
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KR101800956B1 (en) | 2016-04-04 | 2018-01-25 | 주식회사 와이제이테크 | Composition for preventing hair loss and stimulating hair growth comprising phytosphingosine and yeast extract as active ingredients |
Cited By (6)
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KR102209294B1 (en) * | 2020-05-19 | 2021-02-01 | 주식회사 엑소코바이오 | Freeze-dried formulation of exosomes derived from stem cell and composition comprising the same for promoting hair growth or preventing hair loss |
KR102195880B1 (en) * | 2020-09-01 | 2020-12-29 | 주식회사 한미양행 | Composition for hair loss prevention or hair growth promotion containing cricket and Tenebrio molitor treated with high-pressure by steaming process and enzyme-decomposed |
KR20220118679A (en) * | 2021-02-19 | 2022-08-26 | 대경대학교 산학협력단 | Hair Essence Composition Comprising Jujube Extract and Manufacturing Method thereof |
KR102363835B1 (en) | 2021-08-10 | 2022-02-16 | 주식회사 에이치엔비웰 | Cosmetic composition for hair and scalp containing fermented natural plant extracts complex |
KR102488287B1 (en) * | 2022-01-03 | 2023-01-13 | 주식회사 마미야 | Health food containing biotin |
KR102418114B1 (en) | 2022-02-24 | 2022-07-07 | 주식회사 에이치엔비웰 | Cosmetic composition for enhancing hair volume and scalp condition containing natural complex extract |
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