CN103284940A - Saccharomycetes fermented traditional Chinese medicine composition, as well as preparation method and application thereof - Google Patents
Saccharomycetes fermented traditional Chinese medicine composition, as well as preparation method and application thereof Download PDFInfo
- Publication number
- CN103284940A CN103284940A CN2013102651360A CN201310265136A CN103284940A CN 103284940 A CN103284940 A CN 103284940A CN 2013102651360 A CN2013102651360 A CN 2013102651360A CN 201310265136 A CN201310265136 A CN 201310265136A CN 103284940 A CN103284940 A CN 103284940A
- Authority
- CN
- China
- Prior art keywords
- chinese medicine
- parts
- fermentation
- radix
- yeast
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Images
Landscapes
- Cosmetics (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Abstract
The invention discloses an saccharomycetes fermented traditional Chinese medicine composition, as well as a preparation method and application thereof, and relates to a fermented composition prepared by commonly fermenting saccharomycetes and traditional Chinese medicines or traditional Chinese medicine extractives and application thereof in the field of cosmetics. According to the invention, a part of traditional Chinese medicines including radix paeoniae alba, rhizoma bletillae, bighead atractylodes rhizome, radix ampelopsis, poria cocos, liquorice, ginseng and astragalus membranaceus having the effects of hairdressing and protecting skin is selected; the saccharomycetes fermented traditional Chinese medicine composition is prepared by selecting any one or more of the traditional Chinese medicines to form a compound according to proper parts by weight, crushing, immersing, extracting, fermenting through candida lambica and/or rhodotorula rubra, and carrying out enzymolysis of fermentation liquor; the fermented composition used as an adding ingredient is added into a cosmetic according to the known method in the cosmetic industry to form an external preparation, such as a cream cosmetic, an emulsion cosmetic, a water cosmetic, a gel cosmetic, an aesthetic cosmetic or a skin protection cosmetic, and therefore, the effects of protecting, nourishing, caring and strengthening skin are achieved.
Description
Technical field
The present invention relates to the fermentation composition of yeast and Chinese medicine or Chinese medicine extract co-fermentation preparation and the application in cosmetic field thereof, but particularly relating to Chinese medicine or Chinese medicine extract must candida mycoderma and/or the rhodothece rubra fermentation through the youth, the fermentation composition that fermentation liquid makes through enzymolysis, and this fermentation composition for the preparation of whiten, preserve moisture, application in the anti-wrinkle cosmetic.
Background technology
In recent years, the cosmetics market development is very rapid.The cosmetics of natural material preparation become the major trend of domestic and international cosmetics research and development because effect is obvious, side effect is little, is subjected to consumers in general's welcome.
In China, utilize the with a long history of Chinese herbal medicine beauty treatment.Accumulated the data of many relevant this respects on the document.Remarkable with beauty treatment clinical practice checking effect through the daily health caring that people are long-term.For example: seven white cream are classics beauty treatments ancient prescriptions of putting down in writing in the Holy Benevolent Prescriptions, and this side is made up of seven flavor medicines such as the Radix Angelicae Dahuricae, Radix Ampelopsis, the Rhizoma Atractylodis Macrocephalae, Rhizoma Typhonii, Poria, Pseudobulbus Bletillae (Rhizoma Bletillae), Herba Asaris, and Pear Power skin makes skin smooth, moist effect.
The beautification function of single medicinal material also has a lot of records.For example: " Bencao Pinhui Jingyao " said: " Poria is the end, close honey and, treat the black bleb of acne vulgaris and puerpera such as Ovum passeris on the flush coat." Poria can remove the black and white face, firm tooth black hair again, life lengthening." property of medicine opinion " cloud " Pseudobulbus Bletillae (Rhizoma Bletillae) is controlled skin ulcer on the face, makes us flesh and slides ".Compendium of Material Medica cloud " Pseudobulbus Bletillae (Rhizoma Bletillae), it is black to wash one's face, speckle dispelling ".Dip in the shape of wine (or vinegar) as rubbing an ink stick on an inkstone with the Rhizoma Atractylodis Macrocephalae, evenly smear on the face, can control freckle and black speck, holy doctor's Li Shizhen (1518-1593 A.D.) said once that this side controlled freckle " ultimate attainment ".
Modern study confirms that some composition of Chinese medicine has effects such as skin Caring, skin and complexion improving really.
The Radix Paeoniae Alba: the free radical of removing, antioxidative effect are arranged; Effect with antiinflammatory, blood vessel dilating etc.
Radix Ampelopsis: the Radix Ampelopsis water extract has higher tyrosinase inhibitory action.
The Rhizoma Atractylodis Macrocephalae: can dispel skin black speck black halo, the acne cicatrix.
Radix Ginseng: just be regarded as famous and precious traditional Chinese medical science medical material since ancient times, have the blood circulation promoting effect, can prevent that xerosis cutis is aging, enhance metabolism, repair and keep the healthy base state of skin, make skin normalization.
The Radix Astragali: dispelling speckles and whitening face, reduce pigmentation, the nutrition skin promotes the skin resistance against diseases, slow down aging, skin care is whitened, and removes yellow gas, makes skin health glossy, to removing the blackhead hoary hair good effect is arranged all simultaneously.
Radix Glycyrrhizae: Radix Glycyrrhizae extract is a kind of good whitening composition, as licoflavone, glycyrrhizic acid (a kind of pentacyclic triterpene acid), its mechanism of whitening is mainly to the inhibition of tryrosinase, dopachrome tautomerase activity with to the obstruction of the polymerization of 5,6--dihydroxy indole (DHI).
For excavating the elite of motherland's medical science, relevant scholar has proposed the fermentation technique of Chinese medicine.From biological viewpoint, not only microorganism has the effect of skin protection, skin and complexion improving owing to some inherent characteristicses of itself; And a large amount of secondary metabolites can participate in the metabolism of microorganism in the Chinese medicine, promotes microbial growth, and the active component in the Chinese medicine also might be produced new material by microbial transformation or modification, for the research and development of cosmetics have indicated a direction.
Chinese medicine itself has comprised complicated chemical constituent, it is a natural compound library, Chinese medicine is added yeast fermentation, on the one hand, the enzyme that yeast produces (invertase, alpha-galactosidase, acid phosphatase matter enzyme, L-Asnase, aminoacid peptidase II, propiono-beta-glucosidase, glucoamylase etc.), active component in the Chinese medicine may be transformed, produce active stronger metabolite; On the other hand, the active substance in the Chinese medicine (as polysaccharide, flavone, terpenoid etc.) may be regulated saccharomycetic metabolism, stimulates (inducing) yeast to produce new metabolite or excessive synthetic certain chemical compound; In addition, the toxicant in the Chinese medicine can be utilized by the yeast degraded, to eliminate the toxic and side effects of Chinese medicine.
Yeast extract can be brought into play its unique effect as natural safe activity thing in cosmetics." skin whitening efficacy of pure natural yeast extract " (daily chemical industry, 2011,41, (4)) described Gaspar etc. and confirmed that by human experimentation yeast extract has the safety of the vitamin that can match in excellence or beauty, has the remarkable effect of improving skin, comprise and improve skin coarseness etc. that experimenter oneself appraisal result shows that yeast extract has the effect of good brilliant white skin simultaneously.(the cosmetic results of Fissione-Y such as Xi Puying tree, Chinese cosmetics scientific seminar in 2006, meeting paper) a kind of new yeast extract Fissione-Y of exploitation, confirm that by in white melanoma cell B16, adding 3% active matter this yeast extract can significantly reduce melanin, human experimentation shows that Fissione-Y can obviously improve hereditary skin allergy symptom, can reduce the percutaneous moisture loss of skin simultaneously.
Yeast extract contains rich in amino acid, oligopeptide and trace element and comprises various vitamin and mineral.Aminoacid plays a part indispensable in skin nursing as the contained composition of skin itself; Various oligopeptides compositions can be used as signaling molecule, participate in various biological respinses, such as can competing with tryrosinase, thereby suppress melanic generation; Vitamin and mineral are good nutrients, and vitamin A and vitamin C itself have good white-skinned face function simultaneously.
The yeast fermentation Chinese medicine composition may play certain synergistic function, and is more more obvious than single Chinese medicine or single yeast Dissolve things inside effect, for cosmetics market provides a kind of new developing direction.Theme of the present invention is to utilize candida lambica and/or rhodothece rubra to ferment with the Chinese medicine that the present invention uses, to realize the synergism of yeast and Chinese medicine, by cell wall self-dissolving and enzymolysis processing, extract yeast content and Chinese medicine ingredients, be used for cosmetics.The result is surprisingly found out that Chinese medicine adds in the cosmetics through the fermentation composition of yeast co-fermentation Processing of Preparation, can significantly improve the effect of cosmetics skin protection, foster skin, skin Caring, skin and complexion improving.
Summary of the invention
An object of the present invention is to provide a kind of yeast fermentation Chinese medicine composition, the Chinese medicine that uses is selected from the part Chinese medicine with beauty and skin care effect: the Radix Paeoniae Alba, Pseudobulbus Bletillae (Rhizoma Bletillae), the Rhizoma Atractylodis Macrocephalae, Radix Ampelopsis, Poria, Radix Glycyrrhizae, Radix Ginseng, the Radix Astragali, select wherein any one Chinese medicine or several Chinese medicine to form compound recipe by suitable weight portion, make by the following method, selected Chinese medicine is pulverized, add suitable quantity of water, soaked 0.5～2 hour, 100 ℃ were extracted 5～30 minutes, add glucose, adjust about pH value to 6.0, sterilization obtains the substrate for yeast fermentation continue the back; When substrate temperature is down to 30 ℃ of left and right sides, inoculate pre-incubated saccharomycetic bacterium liquid, cultivate or about 2～6 days of the aerobic cultivation of fermentation tank in 25 ℃～35 ℃ shaking tables, static placement 1～4 day, survey below the pH value to 5.5, finish fermentation, in fermentation liquid, add enzyme then, enzymolysis, after the stabilizing treatment, centrifugal, get supernatant, sterilization or interpolation antiseptic namely obtain the yeast fermentation Chinese medicine composition.
The weight portion content of described Chinese medicine is: Radix Paeoniae Alba 0-30 part, Pseudobulbus Bletillae (Rhizoma Bletillae) 0-20 part, Rhizoma Atractylodis Macrocephalae 0-30 part, Radix Ampelopsis 0-20 part, Poria 0-40 part, Radix Glycyrrhizae 0-50 part, Radix Ginseng 0-50 part, Radix Astragali 0-50 part, the content of above-mentioned each Chinese medicinal components can not be 0 part simultaneously.
A preferred version of this yeast fermentation Chinese medicine composition is by yeast the following Chinese medicine compound co-fermentation of forming according to weight portion to be made: 15 parts of the Radix Paeoniae Albas, 10 parts of Pseudobulbus Bletillae (Rhizoma Bletillae), 10 parts of the Rhizoma Atractylodis Macrocephalaes, 10 parts of Radix Ampelopsis, 15 parts in Poria, 15 parts in Radix Glycyrrhizae, 10 parts of Radix Ginsengs, 15 parts of the Radixs Astragali.
Another preferred version of this yeast fermentation Chinese medicine composition is by yeast the following Chinese medicine compound co-fermentation of forming according to weight portion to be made: 15 parts of the Radix Paeoniae Albas, 15 parts of Pseudobulbus Bletillae (Rhizoma Bletillae), 15 parts of the Rhizoma Atractylodis Macrocephalaes, 15 parts of Radix Ampelopsis, 15 parts in Poria, 15 parts in Radix Glycyrrhizae, 10 parts of Radix Ginsengs.
Another preferred version of this yeast fermentation Chinese medicine composition is by yeast the following Chinese medicine compound co-fermentation of forming according to weight portion to be made: 40 parts of the Radixs Astragali, 25 parts in Poria, 25 parts in Radix Glycyrrhizae, 10 parts of Radix Ginsengs.
Another object of the present invention provides the preparation method of above-mentioned yeast fermentation Chinese medicine composition, and step is:
1) getting selected Chinese medicine pulverizes, add suitable quantity of water, water volume ml: quality of medicinal material g=40:1～10:1, soaked 0.5～2 hour, 100 ℃ were extracted 5～30 minutes, added glucose, its quality g/ volume ml is 0～0.5%, adjust about pH value to 6.0, and in 115 ℃ down sterilization obtain the substrate for yeast fermentation continue the back after 30～60 minutes;
When 2) temperature of the substrate that is used for yeast fermentation that obtains when step 1) is down to 30 ℃ of left and right sides, inoculate pre-incubated saccharomycetic bacterium liquid, cultivate or the aerobic cultivation of fermentation tank 2～6 days in 25 ℃～35 ℃ shaking tables, static placement 1～4 day, survey below the pH value to 5.5, finish fermentation, obtain yeast fermentation liquor;
3) get step 2) yeast fermentation liquor that obtains, add enzyme, in 50～60 ℃, enzymolysis 2～10 hours, 100 ℃ of stabilizing treatment 10 minutes, centrifugal, get supernatant, sterilization or add antiseptic namely obtains yeast fermentation Chinese medicine composition of the present invention.
But the yeast described in the preparation method of above-mentioned yeast fermentation Chinese medicine composition be selected from the youth must candida mycoderma (Candida lambica) CGMCC AS 2.1763 and rhodothece rubra (Rhodotorula rubra) CGMCC AS 2.1817 in a kind of or two kinds.
The yeast cell wall is comparatively tough and tensile, must could extract content through broken wall treatment.The process of extracting content from yeast is a lot: as autolysis method, enzymatic isolation method, salt full-boiled process, alkaline process, high pressure homogenize breaking cellular wall method etc.According to the purposes characteristics, the present invention selects the autolysis method technology that combines with enzymatic isolation method.
The selected enzyme of enzymolysis described in the preparation method of above-mentioned yeast fermentation Chinese medicine composition is selected from one or both in pectase and the yeast extracting enzyme.
A further object of the present invention provides the application of yeast fermentation Chinese medicine composition of the present invention in the preparation cosmetics.The yeast fermentation Chinese medicine composition that contains the skin-care effect Chinese medicine ingredients that obtains as stated above can be used as adding ingredient, is applied to the production of cosmetics.Can yeast fermentation Chinese medicine composition of the present invention be added into according to method known in the cosmetics industry and make external preparation in the cosmetics, as cream kind, emulsion class, water class, gel-like, beauty treatment class or skin-care cosmetics, reach the effect of skin protection, foster skin, skin Caring, skin and complexion improving.
In general, the addition of yeast fermentation Chinese medicine composition of the present invention can be determined according to the principle of in stable condition, product safety, reliable effect according to factors such as Product Status, character, purposes.
Beneficial effect of the present invention:
But use among the present invention the youth must candida mycoderma (Candida lambica) CGMCC AS 2.1763 and rhodothece rubra (Rhodotorula rubra) CGMCC AS 2.1817 in one or both fermented tcms, on the one hand, yeast is in metabolic process, the abundant enzyme that produces is modified and is transformed Chinese medicine ingredients, the small-molecule substance that macromolecular substances is converted into be easy to absorb; On the other hand, the abundant protein that yeast contains, aminoacid, vitamin B group and trace element can be safeguarded the microecological environment of skin effectively.Utilize the cosmetics of this method preparation, can promote the metabolism of human body skin, method is easy, and the products obtained therefrom green safety easily absorbs, and has reached skin protection, has supported the effect of skin, skin and complexion improving.The yeast fermentation Chinese medicine composition of gained of the present invention can be used as cosmetics additive, has purposes widely in the preparation cosmetics.
Description of drawings
Fig. 1 is the physical beauty's white effect Test Drawing that contains yeast fermentation Chinese medicine composition cosmetics provided by the invention.
The specific embodiment
In the present invention, through the resulting yeast fermentation Chinese medicine composition of yeast fermentation post processing, said composition contains yeast extract and Chinese medicine extract, usually is called fermentation composition for short by selected Chinese medicine.
Further describe hereinafter with reference to the present invention of embodiment, but should not regard limitation of the present invention as.
Embodiment 1: the preparation of yeast fermentation Chinese medicine composition A
Press the column weight amount and take by weighing each Chinese medicine ingredients: Radix Paeoniae Alba 15g, Poria 15g, Radix Glycyrrhizae 15g, Radix Astragali 15g, Radix Ginseng 10g, Rhizoma Atractylodis Macrocephalae 10g, Pseudobulbus Bletillae (Rhizoma Bletillae) 10g, Radix Ampelopsis 10g.Pulverizing adds 22 times of water loggings bubbles 60 minutes, in 100 ℃ of extractions 10 minutes, adjusts about pH value to 6.0, and sterilizes 50 minutes down in 115 ℃.When temperature is down to 30 ℃ of left and right sides, but inoculating pre-incubated youth must the about 1.0%(volume of candida mycoderma (Candida lambica) CGMCC AS2.1763) bacterium liquid, (every liter of fermentation liquid ventilation 3～6L/min) is after about 3 days for 30 ℃ of fermentor cultivation, static placement 3 days, detect pH value and be down to below 5.5, finish fermentation, add 0.6g pectase and 0.6g yeast extracting enzyme, in 50-55 ℃, enzymolysis 4 hours.100 ℃ of stabilizing treatment 10 minutes, centrifugal, collect supernatant.The sterilization or add an amount of antiseptic, namely obtain the yeast fermentation compositions A for cosmetics.
But described youth must candida mycoderma (Candida lambica) CGMCC AS 2.1763 bacterial strains can be buied by Chinese common micro-organisms culture presevation administrative center.
Embodiment 2: the preparation of yeast fermentation Chinese medicine composition B
Press the column weight amount and take by weighing each Chinese medicine ingredients: Rhizoma Atractylodis Macrocephalae 15g, Radix Paeoniae Alba 15g, Pseudobulbus Bletillae (Rhizoma Bletillae) 15g, Radix Ampelopsis 15g, Poria 15g, Radix Glycyrrhizae 15g, Radix Ginseng 10g.Pulverize, add 22 times of water loggings and steeped 50 minutes, and in 100 ℃ of extractions 10 minutes, add glucose 4g, adjust about pH value to 6.0, and sterilized 40 minutes down in 115 ℃.When temperature is down to 30 ℃ of left and right sides, but inoculating pre-incubated youth must the about 1.0%(volume of candida mycoderma (Candida lambica) CGMCC No.2.1763) bacterium liquid, after 30 ℃ of shaking tables are cultivated about 3 days, static placement 3 days, detect pH value and be down to below 5.5, finish fermentation, add 0.6g pectase and 0.6g yeast extracting enzyme, in 50-55 ℃, enzymolysis 4 hours.100 ℃ of stabilizing treatment 10 minutes, centrifugal, collect supernatant.The sterilization or add an amount of antiseptic, namely obtain the yeast fermentation compositions B for cosmetics.
But described youth must candida mycoderma (Candida lambica) CGMCC AS 2.1763 bacterial strains can be buied by Chinese common micro-organisms culture presevation administrative center.
Embodiment 3: the preparation of yeast fermentation Chinese medicine composition C
Press the column weight amount and take by weighing each Chinese medicine ingredients: Radix Astragali 40g, Poria 25g, Radix Glycyrrhizae 25g, Radix Ginseng 10g.Pulverize, add 22 times of water loggings and steeped 50 minutes, and in 100 ℃ of extractions 10 minutes, add glucose 6g, adjust about pH value to 6.0, and sterilized 40 minutes down in 115 ℃.When temperature is down to 30 ℃ of left and right sides, inoculate pre-incubated rhodothece rubra (Rhodotorula rubra) CGMCC AS 2.1817 about 1.0%(volume) bacterium liquid, after 30 ℃ of shaking tables are cultivated about 3 days, static placement 2 days, detect pH value and be down to below 5.5, finish fermentation, add 0.6g yeast extracting enzyme, in 55 ℃, enzymolysis 4 hours.100 ℃ of stabilizing treatment 10 minutes, centrifugal, collect supernatant.The sterilization or add an amount of antiseptic, namely obtain the yeast fermentation compositions C for cosmetics.
Described rhodothece rubra (Rhodotorula rubra) CGMCC AS 2.1817 bacterial strains can be buied by Chinese common micro-organisms culture presevation administrative center.
Embodiment 4: the preparation of the fermentation composition D of yeast fermentation single medicinal material
Choosing single medicinal material and ferment, is example with the Radix Glycyrrhizae: extracting liquorice 100g pulverizes, and adds 20 times of water loggings and steeps 50 minutes, and in 100 ℃ of extractions 10 minutes, add glucose 8g, adjusts about pH value to 6.0, and sterilizes 40 minutes down in 115 ℃.When temperature is down to 30 ℃ of left and right sides, but inoculating pre-incubated youth must candida mycoderma (Candida lambica) CGMCC AS 2.1763 and rhodothece rubra (Rhodotorula rubra) CGMCC AS 2.1817 each about 1.0%(volume) bacterium liquid, after 30 ℃ of shaking tables are cultivated about 3 days, static placement 2 days, detect pH value and be down to below 5.5, finish fermentation, add 0.6g yeast extracting enzyme, in 55 ℃, enzymolysis 10 hours.100 ℃ of stabilizing treatment 10 minutes, centrifugal, collect supernatant.The sterilization or add an amount of antiseptic, namely obtain the yeast fermentation compositions D for cosmetics.
But described youth must candida mycoderma (Candida lambica) CGMCC AS 2.1763 bacterial strains and rhodothece rubra (Rhodotorula rubra) CGMCC AS 2.1817 bacterial strains can be buied by Chinese common micro-organisms culture presevation administrative center.
Embodiment 5: contain the preparation of the cleansing milk of fermentation composition of the present invention
Cleansing milk composition of raw materials (referring to table 1)
Table 1: contain fermentation composition C cleansing milk prescription of the present invention
Preparation method:
Add deionized water in the manufacturing pot, start heating, stir, add sodium laureth sulfate, sodium lauryl sulfate, be heated to 85 ℃, be stirred to dissolving fully, be incubated 10 minutes, begin to lower the temperature; Cool to 75 ℃ and add coconut oleoyl amine MEA, glycol distearate, be stirred to whole dissolvings, continue cooling; Cool to 60 ℃ and add glycerol, cocamido propyl betaine, fermentation composition C, acrylic acid (ester) analog copolymer, citric acid, stir; Add diazolidinyl urea, iodine propilolic alcohol butyl mephenesin Carbamate, essence, sodium chloride at last, stir, namely.
Embodiment 6: contain the preparation of the water class cosmetics of fermentation composition of the present invention
Water class cosmetic material prescription (referring to table 2)
Table 2: contain fermentation composition A of the present invention equilibrium water prescription
Preparation method
Add deionized water in the emulsifying pot, start stirring, add carbomer. fully dispersed with stirring is even, add allantoin, glycerol, propylene glycol, be heated to 85 ℃, be incubated 10 minutes, add Jojoba wax PEG-120 esters, beta glucan, glycyrrhizic acid dipotassium, tocopherol acetas, fermentation composition A, stir.Cool to 45 ℃; Take by weighing essence, the PEG-40 castor oil hydrogenated after stirring, adds the emulsifying pot, adds diazolidinyl urea, iodine propilolic alcohol butyl mephenesin Carbamate, and triethanolamine stirs, namely.
Embodiment 7: contain the preparation of the cream kind cosmetics of fermentation composition of the present invention
Cream kind cosmetic material prescription (referring to table 3)
Table 3: contain fermentation composition B day cream prescription of the present invention
Preparation method:
Deionized water adds kettle, starts stirring, adds carbomer and is uniformly dispersed, and adds glycerol, fermentation composition, methyl hydroxybenzoate again and is heated to 85 ℃, is incubated 10 minutes; Glyceryl stearate, Dormant oils, C10-16 alkyl androstanediol, different ethylhexyl palmitate, vaseline, caprylic/capric triglyceride, polydimethylsiloxane, cetearyl alcohol, PEG-25 cetearyl alcohol, propyl hydroxybenzoate are added oil cauldron successively, be stirred and heated to 85 ℃, be incubated 10 fens kinds; The emulsifying pot is preheating to 40 ℃, and evacuation draws water earlier, and stirring is opened in oil pumping again, and raw material exhausts, and homogenizing 3 minutes is incubated 5 minutes; Add fermentation composition B, stir cooling; Cool to 50 ℃, add triethanolamine; Stirring cools to 45 ℃, adds essence, diazolidinyl urea, iodine propilolic alcohol butyl mephenesin Carbamate, stirs and cools to 36 ℃, namely.
Embodiment 8: contain the preparation of the gel-like cosmetics of fermentation composition of the present invention
Gel-like cosmetic material prescription (referring to table 4)
Table 4: contain fermentation composition D gel-like cosmetic formulations of the present invention
Preparation method:
Add deionized water in the emulsifying pot, start stirring, add carbomer. fully be uniformly dispersed, add glycerol, propylene glycol, be heated to 85 ℃, add Jojoba wax PEG-120 esters, allantoin, fermentation composition D, beta glucan successively, be incubated 10 minutes, cool to 45 ℃; Take by weighing essence, the PEG-40 castor oil hydrogenated after stirring, adds the emulsifying pot, adds diazolidinyl urea, iodine propilolic alcohol butyl mephenesin Carbamate, tocopherol acetas, stirs; Add triethanolamine again, stir, namely.
Further, according to yeast fermentation Chinese medicine composition of the present invention, when it uses as functional beauty treatment/cosmetics additive, wherein also can contain and be selected from ultraviolet absorber, antiinflammatory, antioxidant, benzofuran derivatives, one or more auxiliary elements that complexing of metal ion agent and skin are penetrating dose.
Embodiment 9: the cosmetics human body that the contains fermentation composition of the present invention test of whitening
Select embodiment 7 samples for use, and prepare sample sample in contrast with fermentation composition B in the deionized water replacement prescription with quadrat method.Select 16 volunteers and experimentize, 25 years old mean age, M-F 6:10.All volunteers to be tried position skin all no abnormal, do not smear any external preparation yet.Get the inboard labelling 3cm of volunteer right-hand man's forearm * 3cm pilot region, same arm can be with a plurality of zones of tense marker, interregional 2 cm that are divided into.Specimen and control sample all are randomly dispersed on the arm of the left and right sides.The dermal melanin tester that uses German CK company to produce is tried the measurement of zone and control zone, and each zone is parallel assay 3 times successively.Measure the blank value of each test zone earlier, then by (50 ± 2) mg sample/cm
2Consumption, use latex finger cot that sample is evenly coated in the trial zone.Smear the sample that prepared every day once, measure the dermal melanin content that was tried zone and control zone on the the the the the 7th, the 14th, the 21st, the 28th, the 35th, the 42nd day after smearing respectively.Same volunteer's test is finished by same survey crew.Draw the melanin changing value (referring to table 5) of each sample in 6 weeks, and the melanin change curve that draws (referring to accompanying drawing 1).As can be seen, the sample that contains fermentation composition of the present invention has the melanic effect of obvious reduction, demonstrates whitening effect preferably.
Melanin value and 0 all blank values relatively reduce percentage rate in table 5:6 week
The usage of cosmetics of the present invention and consumption can use according to common usage and the consumption of similar cosmetics.For the heavier position of pigmentation, can appropriateness increase number of times and consumption.
Claims (9)
1. yeast fermentation Chinese medicine composition, it is characterized in that: will comprise the Chinese medicine of the Radix Paeoniae Alba, Pseudobulbus Bletillae (Rhizoma Bletillae), the Rhizoma Atractylodis Macrocephalae, Radix Ampelopsis, Poria, Radix Glycyrrhizae, Radix Ginseng and the Radix Astragali, and select wherein any one Chinese medicine or several Chinese medicine to form compound recipe by suitable weight portion, and make by the following method, above-mentioned selected Chinese medicine is pulverized, add suitable quantity of water, soaked 0.5～2 hour, 100 ℃ were extracted 5～30 minutes, add glucose, adjust about pH value to 6.0, sterilization obtains the substrate for yeast fermentation continue the back; When substrate temperature is down to 30 ℃ of left and right sides, inoculate pre-incubated saccharomycetic bacterium liquid, cultivate or about 2～6 days of the aerobic cultivation of fermentation tank in 25 ℃～35 ℃ shaking tables, static placement 1～4 day, survey below the pH value to 5.5, finish fermentation, in fermentation liquid, add enzyme then, enzymolysis, after the stabilizing treatment, centrifugal, get supernatant, sterilization or interpolation antiseptic namely obtain the yeast fermentation Chinese medicine composition.
2. yeast fermentation Chinese medicine composition according to claim 1, it is characterized in that: described Chinese medicinal components content is: Radix Paeoniae Alba 0-30 part, Pseudobulbus Bletillae (Rhizoma Bletillae) 0-20 part, Rhizoma Atractylodis Macrocephalae 0-30 part, Radix Ampelopsis 0-20 part, Poria 0-40 part, Radix Glycyrrhizae 0-50 part, Radix Ginseng 0-50 part, Radix Astragali 0-50 part, the content of above-mentioned each Chinese medicinal components can not be 0 part simultaneously.
3. yeast fermentation Chinese medicine composition according to claim 2 is characterized in that: by yeast the following Chinese medicine compound co-fermentation of forming according to weight portion is made: 15 parts of the Radix Paeoniae Albas, 10 parts of Pseudobulbus Bletillae (Rhizoma Bletillae), 10 parts of the Rhizoma Atractylodis Macrocephalaes, 10 parts of Radix Ampelopsis, 15 parts in Poria, 15 parts in Radix Glycyrrhizae, 10 parts of Radix Ginsengs, 15 parts of the Radixs Astragali.
4. yeast fermentation Chinese medicine composition according to claim 2 is characterized in that: by yeast the following Chinese medicine compound co-fermentation of forming according to weight portion is made: 15 parts of the Radix Paeoniae Albas, 15 parts of Pseudobulbus Bletillae (Rhizoma Bletillae), 15 parts of the Rhizoma Atractylodis Macrocephalaes, 15 parts of Radix Ampelopsis, 15 parts in Poria, 15 parts in Radix Glycyrrhizae, 10 parts of Radix Ginsengs.
5. yeast fermentation Chinese medicine composition according to claim 2 is characterized in that: by yeast the following Chinese medicine compound co-fermentation of forming according to weight portion is made: 40 parts of the Radixs Astragali, 25 parts in Poria, 25 parts in Radix Glycyrrhizae, 10 parts of Radix Ginsengs.
6. the preparation method of the arbitrary described yeast fermentation Chinese medicine composition of claim 1-5, it is characterized in that: step is:
1) getting selected Chinese medicine pulverizes, add suitable quantity of water, water volume ml: quality of medicinal material g=40:1～10:1, soaked 0.5～2 hour, 100 ℃ were extracted 5～30 minutes, added glucose, its quality g/ volume ml is 0～0.5%, adjust about pH value to 6.0, and in 115 ℃ down sterilization obtain the substrate for yeast fermentation continue the back after 30～60 minutes;
When 2) temperature of the substrate that is used for yeast fermentation that obtains when step 1) is down to 30 ℃ of left and right sides, inoculate pre-incubated saccharomycetic bacterium liquid, cultivate or the aerobic cultivation of fermentation tank 2～6 days in 25 ℃～35 ℃ shaking tables, static placement 1～4 day, survey pH value, to below 5.5, finish fermentation, obtain yeast fermentation liquor;
3) get step 2) yeast fermentation liquor that obtains, add enzyme, in 50～60 ℃, enzymolysis 2～10 hours, 100 ℃ of stabilizing treatment 10 minutes, centrifugal, get supernatant, sterilization or add antiseptic.
7. the preparation method of yeast fermentation Chinese medicine composition according to claim 6 is characterized in that: but described yeast be selected from the youth must candida mycoderma (Candida lambica) CGMCC AS 2.1763 and rhodothece rubra (Rhodotorula rubra) CGMCC AS 2.1817 in a kind of or two kinds.
8. according to the preparation method of claim 6 or 7 described yeast fermentation Chinese medicine compositions, it is characterized in that the described enzyme of enzymolysis is selected from one or both in pectase and the yeast extracting enzyme.
9. the application of the arbitrary described yeast fermentation Chinese medicine composition of claim 1-5 in the preparation cosmetics.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201310265136.0A CN103284940B (en) | 2013-06-28 | 2013-06-28 | Saccharomycetes fermented traditional Chinese medicine composition, as well as preparation method and application thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201310265136.0A CN103284940B (en) | 2013-06-28 | 2013-06-28 | Saccharomycetes fermented traditional Chinese medicine composition, as well as preparation method and application thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN103284940A true CN103284940A (en) | 2013-09-11 |
| CN103284940B CN103284940B (en) | 2014-08-06 |
Family
ID=49086838
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201310265136.0A Active CN103284940B (en) | 2013-06-28 | 2013-06-28 | Saccharomycetes fermented traditional Chinese medicine composition, as well as preparation method and application thereof |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN103284940B (en) |
Cited By (35)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104257545A (en) * | 2014-09-18 | 2015-01-07 | 北京工商大学 | Rhodiola rosea fermentation protoplasm cosmetic and preparation method thereof |
| CN104522815A (en) * | 2015-01-14 | 2015-04-22 | 三株福尔制药有限公司 | Probiotics fermentation maca composition and preparing method and application thereof |
| CN104784233A (en) * | 2015-04-16 | 2015-07-22 | 珲春绿源参业生物科技有限公司 | Method for preparing panaxoside and panaxynol through enzymatic zymotechnics |
| CN104940115A (en) * | 2014-03-28 | 2015-09-30 | 四川省中医药科学院 | New application of lucid ganoderma liquid fermented product and cosmetic prepared from same |
| CN105147584A (en) * | 2015-09-24 | 2015-12-16 | 广州环亚化妆品科技有限公司 | Traditional-Chinese-medicine-ingredient-containing yeast fermentation material, preparing method thereof and application thereof |
| CN105434323A (en) * | 2015-12-22 | 2016-03-30 | 广州市娇兰化妆品有限公司 | Yeast fermentation compound composition and application thereof in whitening and moisturizing skincare products |
| CN106176556A (en) * | 2016-08-31 | 2016-12-07 | 张进 | A kind of removing acnes and controlling oil whitening cream |
| CN106361675A (en) * | 2016-10-31 | 2017-02-01 | 烟台市昊星晟信息技术有限公司 | Preparation method for skin care product from Chinese herbal medicine |
| CN106420565A (en) * | 2016-10-31 | 2017-02-22 | 烟台市昊星晟信息技术有限公司 | Preparation method of Chinese herbal medicine mask |
| CN106860233A (en) * | 2017-01-18 | 2017-06-20 | 长沙协浩吉生物工程有限公司 | A kind of compound method of ferment antiallergy emulsion |
| CN106860388A (en) * | 2017-02-24 | 2017-06-20 | 长沙协浩吉生物工程有限公司 | A kind of compound method of ferment anti-acne emulsion |
| CN106860234A (en) * | 2017-01-18 | 2017-06-20 | 长沙协浩吉生物工程有限公司 | A kind of compound method of ferment antiallergy emulsion |
| CN107028823A (en) * | 2016-02-04 | 2017-08-11 | 北京工商大学 | One kind prepares high security, and microbial fermentation processes of radix glycyrrhizae zymotic fluid with whitening and anti-aging effects and products thereof |
| CN107260649A (en) * | 2017-07-24 | 2017-10-20 | 丘利锦 | A kind of preparation method of jujube facial mask |
| CN107260650A (en) * | 2017-07-24 | 2017-10-20 | 丘利锦 | A kind of preparation method of garlic honey facial mask |
| CN107349302A (en) * | 2017-06-29 | 2017-11-17 | 温州古木生物科技有限公司 | It is a kind of that there is the Chinese medicine composition for repairing sensitive skin effect and its fermentate and application |
| CN107375067A (en) * | 2017-07-24 | 2017-11-24 | 丘利锦 | A kind of preparation method of pollen pini facial mask |
| CN107375170A (en) * | 2017-07-24 | 2017-11-24 | 丘利锦 | A kind of preparation method of Momordica grosvenori facial mask |
| CN107519104A (en) * | 2016-06-17 | 2017-12-29 | 自然解决方案园区有限公司 | Improve functional cosmetic composition and preparation method thereof containing the anti-oxidant of rice washing water fermentation culture medium, anti-wrinkle and moisturizing |
| CN107898743A (en) * | 2017-12-14 | 2018-04-13 | 湖州盛明生物科技有限公司 | The all-round beautifying liquid of whitening and softening skin smoothing wrinkle of all natural more plant enzymolysis extractions |
| CN108244572A (en) * | 2018-02-09 | 2018-07-06 | 米盈食品科技(苏州)有限公司 | Have effects that whitening and prebiotics without sucrose jelly item and preparation method |
| CN109223691A (en) * | 2018-09-30 | 2019-01-18 | 贵州贵和隆科技研发有限公司 | A kind of daily use chemicals ferment and preparation method thereof |
| CN110101625A (en) * | 2019-06-14 | 2019-08-09 | 芳香世家化妆品(广州)有限公司 | A kind of nutrition restorative facial cream |
| CN110327277A (en) * | 2019-08-13 | 2019-10-15 | 马悦馨 | A kind of herbal mixture skin care formulation and preparation method thereof rich in growth factor |
| CN110538123A (en) * | 2019-08-28 | 2019-12-06 | 银川凤仪堂生物工程有限公司 | Preparation process and application of traditional Chinese medicine compound extract for whitening skin and removing freckles |
| CN110680781A (en) * | 2019-10-28 | 2020-01-14 | 上海仪玳化妆品有限公司 | White peony root fermented cosmetic and preparation method and application thereof |
| CN110772459A (en) * | 2019-11-28 | 2020-02-11 | 浙江养生堂天然药物研究所有限公司 | Yeast fermented birch juice and application thereof in whitening cosmetic composition |
| CN111358735A (en) * | 2020-04-21 | 2020-07-03 | 济南碧蒙萱生物技术有限公司 | Lactobacillus rice fermentation product and preparation method thereof |
| CN111588656A (en) * | 2020-04-30 | 2020-08-28 | 杭州谦美化妆品有限公司 | Application of symbiotic fermentation product of hydrolyzed candida and saccharomyces cerevisiae |
| CN112156043A (en) * | 2020-10-19 | 2021-01-01 | 张兴富 | Cosmetic composition containing yeast fermentation product extract and preparation method thereof |
| CN112336672A (en) * | 2020-12-28 | 2021-02-09 | 中华全国供销合作总社南京野生植物综合利用研究所 | Fermentation method of bletilla striata fermentation product and application of bletilla striata fermentation product in whitening cosmetics |
| CN112842976A (en) * | 2019-11-28 | 2021-05-28 | 浙江养生堂天然药物研究所有限公司 | Yeast fermented birch juice and its application in anti-inflammatory cosmetic composition |
| CN113425665A (en) * | 2021-08-12 | 2021-09-24 | 广东药科大学 | Whitening composition capable of reducing toxicity and enhancing efficacy and preparation method and application thereof |
| CN116059119A (en) * | 2023-03-03 | 2023-05-05 | 花安堂生物科技集团有限公司 | Liposome solution containing licorice and glabridin, and preparation method and application thereof |
| CN116270262A (en) * | 2023-03-27 | 2023-06-23 | 花安堂生物科技集团有限公司 | Liposome solution, external preparation containing liposome solution for skin, and preparation method and application of external preparation |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1859921A (en) * | 2003-09-30 | 2006-11-08 | 涌永制药株式会社 | Method of processing ginseng for medicinal use and composition |
| CN103099832A (en) * | 2011-11-10 | 2013-05-15 | 冯淑琴 | Method for biotransformation of pseudo-ginseng by using Candida |
-
2013
- 2013-06-28 CN CN201310265136.0A patent/CN103284940B/en active Active
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1859921A (en) * | 2003-09-30 | 2006-11-08 | 涌永制药株式会社 | Method of processing ginseng for medicinal use and composition |
| CN103099832A (en) * | 2011-11-10 | 2013-05-15 | 冯淑琴 | Method for biotransformation of pseudo-ginseng by using Candida |
Cited By (44)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104940115A (en) * | 2014-03-28 | 2015-09-30 | 四川省中医药科学院 | New application of lucid ganoderma liquid fermented product and cosmetic prepared from same |
| CN104940115B (en) * | 2014-03-28 | 2018-07-06 | 四川省中医药科学院 | The new application of ganoderma lucidum liquid fermentate and cosmetics prepared therefrom |
| CN104257545B (en) * | 2014-09-18 | 2016-08-24 | 北京工商大学 | A kind of Radix Rhodiolae proferment pulp cosmetic and preparation method thereof |
| CN104257545A (en) * | 2014-09-18 | 2015-01-07 | 北京工商大学 | Rhodiola rosea fermentation protoplasm cosmetic and preparation method thereof |
| CN104522815A (en) * | 2015-01-14 | 2015-04-22 | 三株福尔制药有限公司 | Probiotics fermentation maca composition and preparing method and application thereof |
| CN104522815B (en) * | 2015-01-14 | 2016-07-06 | 三株福尔制药有限公司 | A kind of probiotics fermention maca composition and its preparation method and application |
| CN104784233A (en) * | 2015-04-16 | 2015-07-22 | 珲春绿源参业生物科技有限公司 | Method for preparing panaxoside and panaxynol through enzymatic zymotechnics |
| CN105147584B (en) * | 2015-09-24 | 2019-01-29 | 广州环亚生物科技有限公司 | A kind of yeast product and its preparation method and application containing traditional Chinese medicine ingredients |
| CN105147584A (en) * | 2015-09-24 | 2015-12-16 | 广州环亚化妆品科技有限公司 | Traditional-Chinese-medicine-ingredient-containing yeast fermentation material, preparing method thereof and application thereof |
| CN105434323A (en) * | 2015-12-22 | 2016-03-30 | 广州市娇兰化妆品有限公司 | Yeast fermentation compound composition and application thereof in whitening and moisturizing skincare products |
| CN105434323B (en) * | 2015-12-22 | 2018-06-19 | 广州市娇兰化妆品有限公司 | Saccharomycetes to make fermentation compound and its application in skin whitening, moisturizing skin care item |
| CN107028823A (en) * | 2016-02-04 | 2017-08-11 | 北京工商大学 | One kind prepares high security, and microbial fermentation processes of radix glycyrrhizae zymotic fluid with whitening and anti-aging effects and products thereof |
| CN107519104A (en) * | 2016-06-17 | 2017-12-29 | 自然解决方案园区有限公司 | Improve functional cosmetic composition and preparation method thereof containing the anti-oxidant of rice washing water fermentation culture medium, anti-wrinkle and moisturizing |
| CN106176556A (en) * | 2016-08-31 | 2016-12-07 | 张进 | A kind of removing acnes and controlling oil whitening cream |
| CN106361675A (en) * | 2016-10-31 | 2017-02-01 | 烟台市昊星晟信息技术有限公司 | Preparation method for skin care product from Chinese herbal medicine |
| CN106420565A (en) * | 2016-10-31 | 2017-02-22 | 烟台市昊星晟信息技术有限公司 | Preparation method of Chinese herbal medicine mask |
| CN106860233A (en) * | 2017-01-18 | 2017-06-20 | 长沙协浩吉生物工程有限公司 | A kind of compound method of ferment antiallergy emulsion |
| CN106860234A (en) * | 2017-01-18 | 2017-06-20 | 长沙协浩吉生物工程有限公司 | A kind of compound method of ferment antiallergy emulsion |
| CN106860388A (en) * | 2017-02-24 | 2017-06-20 | 长沙协浩吉生物工程有限公司 | A kind of compound method of ferment anti-acne emulsion |
| CN107349302A (en) * | 2017-06-29 | 2017-11-17 | 温州古木生物科技有限公司 | It is a kind of that there is the Chinese medicine composition for repairing sensitive skin effect and its fermentate and application |
| CN107375067A (en) * | 2017-07-24 | 2017-11-24 | 丘利锦 | A kind of preparation method of pollen pini facial mask |
| CN107375170A (en) * | 2017-07-24 | 2017-11-24 | 丘利锦 | A kind of preparation method of Momordica grosvenori facial mask |
| CN107260650A (en) * | 2017-07-24 | 2017-10-20 | 丘利锦 | A kind of preparation method of garlic honey facial mask |
| CN107260649A (en) * | 2017-07-24 | 2017-10-20 | 丘利锦 | A kind of preparation method of jujube facial mask |
| CN107898743A (en) * | 2017-12-14 | 2018-04-13 | 湖州盛明生物科技有限公司 | The all-round beautifying liquid of whitening and softening skin smoothing wrinkle of all natural more plant enzymolysis extractions |
| CN108244572A (en) * | 2018-02-09 | 2018-07-06 | 米盈食品科技(苏州)有限公司 | Have effects that whitening and prebiotics without sucrose jelly item and preparation method |
| CN109223691A (en) * | 2018-09-30 | 2019-01-18 | 贵州贵和隆科技研发有限公司 | A kind of daily use chemicals ferment and preparation method thereof |
| CN110101625A (en) * | 2019-06-14 | 2019-08-09 | 芳香世家化妆品(广州)有限公司 | A kind of nutrition restorative facial cream |
| CN110327277A (en) * | 2019-08-13 | 2019-10-15 | 马悦馨 | A kind of herbal mixture skin care formulation and preparation method thereof rich in growth factor |
| CN110538123A (en) * | 2019-08-28 | 2019-12-06 | 银川凤仪堂生物工程有限公司 | Preparation process and application of traditional Chinese medicine compound extract for whitening skin and removing freckles |
| CN110680781A (en) * | 2019-10-28 | 2020-01-14 | 上海仪玳化妆品有限公司 | White peony root fermented cosmetic and preparation method and application thereof |
| CN110680781B (en) * | 2019-10-28 | 2022-07-05 | 上海仪玳化妆品有限公司 | White peony root fermented cosmetic and preparation method and application thereof |
| CN112842976A (en) * | 2019-11-28 | 2021-05-28 | 浙江养生堂天然药物研究所有限公司 | Yeast fermented birch juice and its application in anti-inflammatory cosmetic composition |
| CN110772459A (en) * | 2019-11-28 | 2020-02-11 | 浙江养生堂天然药物研究所有限公司 | Yeast fermented birch juice and application thereof in whitening cosmetic composition |
| CN112842976B (en) * | 2019-11-28 | 2024-01-02 | 浙江养生堂天然药物研究所有限公司 | Yeast fermented birch juice and its application in anti-inflammatory cosmetic composition |
| CN111358735A (en) * | 2020-04-21 | 2020-07-03 | 济南碧蒙萱生物技术有限公司 | Lactobacillus rice fermentation product and preparation method thereof |
| CN111588656A (en) * | 2020-04-30 | 2020-08-28 | 杭州谦美化妆品有限公司 | Application of symbiotic fermentation product of hydrolyzed candida and saccharomyces cerevisiae |
| CN112156043A (en) * | 2020-10-19 | 2021-01-01 | 张兴富 | Cosmetic composition containing yeast fermentation product extract and preparation method thereof |
| CN112336672A (en) * | 2020-12-28 | 2021-02-09 | 中华全国供销合作总社南京野生植物综合利用研究所 | Fermentation method of bletilla striata fermentation product and application of bletilla striata fermentation product in whitening cosmetics |
| CN113425665A (en) * | 2021-08-12 | 2021-09-24 | 广东药科大学 | Whitening composition capable of reducing toxicity and enhancing efficacy and preparation method and application thereof |
| CN116059119A (en) * | 2023-03-03 | 2023-05-05 | 花安堂生物科技集团有限公司 | Liposome solution containing licorice and glabridin, and preparation method and application thereof |
| CN116059119B (en) * | 2023-03-03 | 2023-06-20 | 花安堂生物科技集团有限公司 | Liposome solution containing licorice and glabridin, and preparation method and application thereof |
| CN116270262A (en) * | 2023-03-27 | 2023-06-23 | 花安堂生物科技集团有限公司 | Liposome solution, external preparation containing liposome solution for skin, and preparation method and application of external preparation |
| CN116270262B (en) * | 2023-03-27 | 2024-01-02 | 花安堂生物科技集团有限公司 | Liposome solution, external preparation containing liposome solution for skin, and preparation method and application of external preparation |
Also Published As
| Publication number | Publication date |
|---|---|
| CN103284940B (en) | 2014-08-06 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN103284940B (en) | Saccharomycetes fermented traditional Chinese medicine composition, as well as preparation method and application thereof | |
| CN101125119B (en) | Tibetan materia medica with whitening anti-senility function and application thereof | |
| JP2021020887A (en) | Enhanced anti-aging cosmetic composition | |
| CN102293733B (en) | Overall whitening and speckle removal skin care product | |
| KR101373636B1 (en) | Composition for improving condition of skin and scalp containing fermented extracts of herb mixture | |
| CN102258442B (en) | Compound traditional Chinese medicine extract and application thereof to whitening, moisturizing and anti-aging skin care product | |
| CN108245479B (en) | Facial mask containing bifidobacterium lactis fermented active extract | |
| CN109453087B (en) | Whitening skin-penetrating lotion, preparation method thereof and whitening cosmetic additive | |
| CN106176348A (en) | Topical skin composition and the method processing skin | |
| CN108403521A (en) | Topical skin composition and application thereof | |
| CN109662904A (en) | It is a kind of to have effects that the skin care compositions of whitening antioxidation and its application and preparation method | |
| CN102274141B (en) | Herba selaginellae revival moisturizing cream and preparation method thereof | |
| CN108670933B (en) | Skin care composition with moisturizing, whitening and anti-aging functions and application thereof | |
| KR101816725B1 (en) | Manufacturing method for fermented extracts and cosmetic composition comprising fermented extracts | |
| US20150182443A1 (en) | Traditional chinese medicine extract composition with whitening skin-care function adn its preparation method | |
| CN105687056B (en) | A kind of Chinese medicine shampoo and preparation method thereof that suitable puerpera uses | |
| CN111265441A (en) | Composition capable of enhancing skin night repair and regeneration capacity and application thereof | |
| CN109431899A (en) | One kind 5 joins circle proferment pulp cosmetic and the preparation method and application thereof | |
| CN105998617A (en) | Externally applied traditional Chinese medicine extract with effect of soothing senile pruritus, as well as preparation method and application thereof | |
| CN109464329A (en) | A kind of goddess's jade flesh virtue proferment pulp cosmetic and the preparation method and application thereof | |
| TW202102239A (en) | Antiaging agent, antioxidant, antiinflammatory agent and whitening agent, and cosmetic | |
| CN110974775A (en) | Allergy-relieving composition containing nostoc sphaeroides and preparation method and application thereof | |
| CN109260134A (en) | A kind of fine jade Rong virtue proferment pulp cosmetic and the preparation method and application thereof | |
| CN105326779A (en) | Moisturizing, brightening and whitening hair gel and preparation method thereof | |
| KR102221137B1 (en) | A lycoris uydoensis extract comprising anti-wrinkle, anti-inflammatory, anti-oxidation activity, and composition comprising the same, and use thereof |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant |