CN110538123A - Preparation process and application of traditional Chinese medicine compound extract for whitening skin and removing freckles - Google Patents
Preparation process and application of traditional Chinese medicine compound extract for whitening skin and removing freckles Download PDFInfo
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9728—Fungi, e.g. yeasts
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9789—Magnoliopsida [dicotyledons]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9794—Liliopsida [monocotyledons]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
- A61Q17/005—Antimicrobial preparations
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/02—Preparations for care of the skin for chemically bleaching or whitening the skin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/74—Biological properties of particular ingredients
- A61K2800/78—Enzyme modulators, e.g. Enzyme agonists
- A61K2800/782—Enzyme inhibitors; Enzyme antagonists
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/80—Process related aspects concerning the preparation of the cosmetic composition or the storage or application thereof
- A61K2800/805—Corresponding aspects not provided for by any of codes A61K2800/81 - A61K2800/95
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/80—Process related aspects concerning the preparation of the cosmetic composition or the storage or application thereof
- A61K2800/81—Preparation or application process involves irradiation
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/80—Process related aspects concerning the preparation of the cosmetic composition or the storage or application thereof
- A61K2800/82—Preparation or application process involves sonication or ultrasonication
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/80—Process related aspects concerning the preparation of the cosmetic composition or the storage or application thereof
- A61K2800/85—Products or compounds obtained by fermentation, e.g. yoghurt, beer, wine
Abstract
The invention belongs to the technical field of cosmetic processing, and relates to a preparation process and application of a traditional Chinese medicine compound extracting solution for whitening and removing freckles. The preparation process of the traditional Chinese medicine compound extracting solution comprises the steps of preparing a concentrated solution of mung beans and mulberry leaves as a first extracting solution, preparing a concentrated solution of liquorice, raspberry and angelica as a second extracting solution, carrying out enzymolysis and fermentation on white paeony root, bletilla striata and chinaroot greenbrier rhizome, preparing a concentrated solution of the white paeony root, the bletilla striata and the chinaroot greenbrier rhizome as a third extracting solution, and mixing the three extracting solutions to obtain the traditional Chinese medicine compound extracting solution; the Chinese medicinal compound extract is used for preparing whitening and freckle-removing face cream. The Chinese medicinal compound extract specifically and respectively extracts main functional components in plants and Chinese medicaments in different extraction modes, and the obtained extract is mixed to combine and superpose the functions, so that the prepared face cream has the effects of safely and efficiently whitening, removing freckles, resisting bacteria and diminishing inflammation.
Description
Technical Field
The invention belongs to the technical field of cosmetic processing, and relates to a preparation process and application of a traditional Chinese medicine compound extracting solution for whitening and removing freckles.
Background
White skin can promote the overall appearance and the quality of the individual, so that the individual looks as wonderful; however, if a large amount of pigments are deposited on the fair skin surface and form color spots, the skin color improvement cannot fully embody the advantage of the skin appearance improvement, and cannot meet the high requirements of people on the skin; therefore, the skin care product with the effects of whitening and removing freckles is an important requirement of the public on skin care products at present, and occupies most of the domestic skin care product market. The existing whitening and freckle-removing products generally carry out uniform extraction on materials with effects in a single extraction mode, so that the extraction degrees of active ingredients of all raw materials are different, and the efficacy levels of the products are different; meanwhile, in the extraction process, the conventional preparation is selected, so that the active ingredients cannot be fully extracted, and the waste of raw materials is caused.
Disclosure of Invention
The invention aims to provide a preparation process of a traditional Chinese medicine compound extracting solution for whitening and removing freckles.
The invention also aims to provide application of the traditional Chinese medicine compound extract for whitening and removing freckles, which is used for preparing face cream, and the prepared face cream has high-efficiency whitening, freckles removing and antibacterial effects.
The technical scheme of the invention for solving the technical problems is as follows.
A preparation process of a traditional Chinese medicine compound extract for whitening and removing freckles comprises the following steps:
(1) Preparing a first extracting solution: adding mung beans and mulberry leaves into ethanol, sequentially carrying out ultrasonic extraction and centrifugal treatment, carrying out evaporation concentration on collected supernate, and sequentially carrying out low-temperature cold turbidity and filtration on obtained concentrated solution to obtain a first extracting solution; mung beans and mulberry leaves are added into ethanol with the concentration of 70 percent according to the dosage of 3 to 15 percent. The mung bean contains a large amount of ellagic acid, amino acids, glycoprotein, etc., and has antioxidant and antiaging effects; the mulberry leaves contain abundant flavonoids and phenolic compounds, and the flavonoids and phenolic compounds have good antioxidation, can improve skin tissues, promote metabolism and inhibit pigmentation. The mung bean alcohol extract and the licorice alcohol extract are obtained by soaking mung bean and mulberry leaf which are temperature sensitive plants in ethanol, extracting with ultrasonic waves and the like, and meanwhile, the effective components of the mung bean alcohol extract and the licorice alcohol extract are fully extracted.
(2) Preparing a second extracting solution: adding Glycyrrhrizae radix, Rubi fructus, and radix Angelicae sinensis into purified water, decocting, storing at low temperature, centrifuging, and filtering to obtain second extractive solution; wherein, the liquorice, the raspberry and the angelica are added into purified water according to the dosage of 0.5 to 5 percent; when the low-temperature preservation is carried out, the temperature is 4-8 ℃ and the time is 40-60 h. The liquorice contains abundant liquiritigenin and liquiritin which can inhibit the activity of tyrosinase and has the effects of whitening, removing freckles, preventing sun, whitening and the like; the raspberry and the angelica contain a large amount of ellagic acid, amino acid, glycoprotein and the like, and have excellent antioxidant and anti-aging effects. The nutrient components in the raw materials are separated out by a high-temperature decoction mode to obtain water extracts of the raw materials, the separated nutrient substances are retained by a low-temperature preservation mode, and the nutrient substances are fully extracted by centrifugal filtration and other modes.
(3) Preparing a third extracting solution: adding radix Paeoniae alba, rhizoma Bletillae, and Poria into purified water, adding cellulase and pectinase for enzymolysis, sequentially inactivating enzyme, cooling, adding stress yeast or Aspergillus niger for fermentation, sequentially sterilizing, and centrifuging to obtain a third extractive solution; wherein, the white paeony root, the bletilla striata and the white poria are added into the purified water according to the dosage of 0.5 to 5 percent; the dosage of the cellulase is 0.1 to 2 percent, and the dosage of the pectinase is 0.1 to 2 percent; during enzymolysis, the temperature is 45-55 ℃ and the time is 2-4 h; the dosage of the stress yeast or the aspergillus niger is 0.1 to 2 percent; culturing the yeast by ultraviolet irradiation for 2-5 h, expanding culture, freezing and drying to obtain the stress yeast. The extract obtained by enzymolysis and fermentation of radix Paeoniae alba, rhizoma Bletillae and Poria contains abundant small molecule peptides, amino acids, lecithin and flavonoids, and has antibacterial and anti-inflammatory effects. After the yeast is irradiated by ultraviolet rays, the finally survived bacteria have certain resistance to the ultraviolet rays, and the essence of the resistance is that the yeast generates self-repairing protein or ultraviolet ray resistant protein; the extract has strong effects of repairing damaged skin and resisting ultraviolet rays by fermentation of stress yeast.
(4) Dissolving the first extractive solution with alcohol solvent, and mixing with the second extractive solution and the third extractive solution to obtain compound Chinese medicinal extractive solution. Specifically, the first extract is dissolved in an alcohol solvent such as propylene glycol or hexylene glycol, and then mixed with the second extract and the third extract. Because the main functional components of each plant are different, the functional components of each plant can be obtained respectively through extraction in different modes.
an application of a traditional Chinese medicine compound extract for whitening and removing freckles is used for preparing a whitening and freckles-removing facial cream.
The whitening and freckle-removing facial cream comprises the following raw materials in parts by mass: 5-50 parts of a traditional Chinese medicine compound extracting solution, 2-50 parts of a purslane extract, 0.5-50 parts of an emulsifier, 0.5-50 parts of a humectant, 0.5-30 parts of a tonic, 0.5-10 parts of a thickening agent, 0.1-5 parts of an essence and 1-95 parts of water.
Adding the raw materials into a homogenizer, and homogenizing at least once under the conditions that the temperature is 50-90 ℃ and the pressure is 2-20 MPa to obtain the whitening and freckle-removing cream.
Further, the emulsifier is one or more of polyoxyethylene oleate, monolaurin, propylene glycol fatty acid ester, sodium stearyl lactate, polyoxyethylene nonylphenol ether, polyoxyethylene stearate, polyglycerol fatty acid ester, sorbitol fatty acid ester, sodium diisooctyl succinate sulfonate or polyoxyethylene fatty acid ester.
Further, the humectant is one or more of glycerol, propylene glycol, polyethylene glycol, sorbitol, polyglutamic acid or xylitol.
Further, the tonic agent is one or more of sodium salicylate, superoxide dismutase, vitamins, dextran, sodium lysine or vitamins.
Further, the thickening agent is one or more of gelatin, sodium carboxymethylcellulose, sodium chloride or sodium alginate.
The preparation process and the application of the traditional Chinese medicine compound extract for whitening and removing freckles have the advantages that main functional components in plants and traditional Chinese medicines are respectively extracted in a targeted manner by different extraction modes, so that all raw materials can fully play roles; mixing the obtained extractive solutions, combining and superposing the effects, and using the extractive solution for preparing facial cream; the obtained cream has safe and effective whitening, speckle removing, antibacterial, and antiinflammatory effects.
Detailed Description
Example 1
A preparation process of a traditional Chinese medicine compound extract for whitening and removing freckles comprises the following steps:
(1) Preparing a first extracting solution: adding mung beans and mulberry leaves into 70% ethanol according to the dosage of 8% and 5% respectively, performing ultrasonic extraction for 0.5-2 h at 50 ℃ and 80Hz, performing centrifugal treatment for 10min at the rotating speed of 4000 rpm, collecting supernate, performing rotary evaporation concentration, removing ethanol, collecting concentrated solution, performing low-temperature cold turbidity for 24h, filtering, and collecting filtrate to obtain a first extracting solution.
(2) preparing a second extracting solution: adding 1%, 3% and 3% of liquorice, raspberry and angelica into purified water respectively, decocting for 1h, storing at low temperature of 4-8 ℃ for 48h, taking out, centrifuging at the rotating speed of 4000 rpm for 10min, performing vacuum filtration on obtained supernatant by using a ceramic membrane, and collecting filtrate to obtain a second extracting solution.
(3) Preparing a third extracting solution: dissolving the white paeony root, the bletilla striata and the white poria in purified water according to the use amounts of 3%, 2% and 5%, adding 1% of cellulase and 1% of pectinase, carrying out enzymolysis for 3h at 50 ℃, inactivating enzymes at 90-120 ℃ after the enzymolysis is finished, cooling to room temperature, adding 0.5% of stress yeast, fermenting for 12-40 h, carrying out high-pressure sterilization and centrifugation after the fermentation is finished, collecting supernate and filtering to obtain a third extracting solution. Wherein the stress yeast is obtained by culturing the yeast by ultraviolet irradiation for 2-5 h, expanding culture, freezing and drying to obtain the stress yeast; after the yeast is irradiated by ultraviolet rays, the finally living bacteria have certain resistance to the ultraviolet rays, and the essence of the resistance is that the yeast generates self-repairing protein or ultraviolet ray resisting protein, so that the third extracting solution has strong effects of repairing damaged skin and resisting the ultraviolet rays.
(4) Dissolving the first extractive solution with propylene glycol, and mixing with the second extractive solution and the third extractive solution to obtain compound extractive solution of Chinese medicinal materials.
Example 2
A preparation process of a traditional Chinese medicine compound extract for whitening and removing freckles comprises the following steps:
(1) preparing a first extracting solution: adding mung beans and mulberry leaves into 70% ethanol according to the dosage of 10% and 3% respectively, performing ultrasonic extraction for 0.5-2 h at 50 ℃ and 80Hz, performing centrifugal treatment for 15min at the rotating speed of 4000 rpm, collecting supernate, performing rotary evaporation concentration, removing ethanol, collecting concentrated solution, performing low-temperature cold turbidity for 24h, filtering, and collecting filtrate to obtain a first extracting solution.
(2) Preparing a second extracting solution: adding 3%, 5% and 0.5% of licorice, raspberry and angelica into purified water, decocting for 1h, storing at 4-8 ℃ for 60h, taking out, centrifuging for 8min at 4000 rpm, vacuum-filtering the obtained supernatant with ceramic membrane, and collecting the filtrate to obtain a second extract.
(3) Preparing a third extracting solution: dissolving radix paeoniae alba, bletilla striata and poria alba in purified water according to the dosage of 2%, 5% and 1%, adding 2% of cellulase and 0.5% of pectinase, carrying out enzymolysis for 4 hours at 55 ℃, inactivating enzymes at 90-120 ℃ after the enzymolysis is finished, cooling to room temperature, adding 0.5% of aspergillus niger, fermenting for 12-40 hours, carrying out autoclaving and centrifugation after the fermentation is finished, collecting supernate and filtering to obtain a third extracting solution.
(4) Dissolving the first extractive solution with hexanediol, and mixing with the second extractive solution and the third extractive solution to obtain compound extractive solution of Chinese medicinal materials.
Example 3
A preparation process of a traditional Chinese medicine compound extract for whitening and removing freckles comprises the following steps:
(1) preparing a first extracting solution: adding mung beans and mulberry leaves into 70% ethanol according to the dosage of 15% and 13% respectively, performing ultrasonic extraction for 0.5-2 h at 50 ℃ and 80Hz, performing centrifugal treatment for 10min at the rotating speed of 4000 rpm, collecting supernate, performing rotary evaporation concentration, removing ethanol, collecting concentrated solution, performing low-temperature cold turbidity for 24h, filtering, and collecting filtrate to obtain a first extracting solution.
(2) preparing a second extracting solution: adding liquorice, raspberry and angelica into purified water according to the use amounts of 3%, 3% and 3% respectively, decocting for 1h, storing at low temperature of 4-8 ℃ for 48h, taking out, centrifuging at the rotating speed of 4000 rpm for 10min, performing vacuum filtration on obtained supernatant by using a ceramic membrane, and collecting filtrate to obtain a second extracting solution.
(3) Preparing a third extracting solution: dissolving radix paeoniae alba, bletilla striata and poria alba in purified water according to the dosage of 2%, 5% and 1%, adding 2% of cellulase and 0.5% of pectinase, carrying out enzymolysis for 4 hours at 55 ℃, inactivating enzymes at 90-120 ℃ after the enzymolysis is finished, cooling to room temperature, adding 2% of stress yeast, fermenting for 12-40 hours, carrying out high-pressure sterilization and centrifugation after the fermentation is finished, collecting supernate and filtering to obtain a third extracting solution. Among them, the stress yeast was obtained in the same manner as in example 1.
(4) dissolving the first extractive solution with hexanediol, and mixing with the second extractive solution and the third extractive solution to obtain compound extractive solution of Chinese medicinal materials.
Example 4
an application of a traditional Chinese medicine compound extract for whitening and removing freckles is to use the traditional Chinese medicine compound extract in example 1, example 2 or example 3 to prepare a whitening and freckles-removing facial cream. The traditional Chinese medicine compound extracting solution in the embodiment 1, the embodiment 2 or the embodiment 3, the purslane extract, the emulsifier, the humectant, the tonic, the thickener, the essence and the water are mixed according to the following mass ratio of 25: 20: 5: 15: 12: 3: 2: 90, adding the mixture into a homogenizer, homogenizing at 50-90 ℃ at 2-20 MPa at least once, and obtaining the homogeneous substance, namely the whitening and freckle-removing face cream of the Chinese herbal medicine.
Wherein the emulsifier is one or more of polyoxyethylene oleate, monolaurin, propylene glycol fatty acid ester, sodium stearyl lactate, nonylphenol polyoxyethylene ether, polyoxyethylene stearate, polyglycerol fatty acid ester, sorbitol fatty acid ester, sodium diisooctyl succinate sulfonate or polyoxyethylene fatty acid ester; the humectant is one or more of glycerol, propylene glycol, polyethylene glycol, sorbitol, polyglutamic acid or xylitol; the tonic agent is one or more of sodium salicylate, superoxide dismutase, vitamin, dextran, lysine sodium or vitamin; the thickener is one or more of gelatin, sodium carboxymethylcellulose, sodium chloride or sodium alginate.
Example 5
The purslane extract in the embodiment 4 is obtained by adding purslane into ethanol and/or glycerol in an amount of 2-10 times, ultrasonically extracting for 1 hour, centrifuging, collecting supernate, concentrating and filtering to obtain a purslane crude extract; diluting the crude extract of herba Portulacae with pure water, and purifying with macroporous adsorbent resin; specifically, during purification, the impurities are removed by using purification water for 30 minutes, then the purslane is eluted by using 80% ethanol solution, the eluent is collected, the eluent is concentrated, and the concentrated solution is collected to obtain the purslane extract.
Example 6
The whitening and freckle-removing facial cream is prepared by the example method of example 4 from the traditional Chinese medicine compound extract obtained by the embodiment of example 1 to example 3, and the content of melanin in cells is measured. Specifically, adding the cell suspension to a culture plate, and adding the Chinese herbal compound extract in the embodiments 1 to 3 and a blank group of 100 μ L into each hole in a manner of 1ml per hole respectively; the plate was cultured in an incubator for 4 days, the medium was poured out and washed with physiological saline 3 times, digested with 0.25% trypsin and collected, the cells were treated with an ultrasonic pulverizer, centrifuged, precipitated, washed with absolute ethanol and centrifuged for 5min to 10min, the supernatant was poured out and 100. mu.L of 1mol/L sodium hydroxide was added, the temperature was maintained at 80 ℃ for 2h, and the A value was measured at 470 nm. As a result, the absorbance A values of example 1, example 2 and example 3 were decreased by 34%, 20% and 28% respectively, and intracellular melanin was significantly decreased, particularly, the extract solutions obtained in example 1 and example 3, to which the stress yeast was added, had a higher ultraviolet ray-resistant effect, compared with the blank group.
Therefore, the cream obtained in the embodiment has safe and efficient whitening, freckle removing, antibacterial and anti-inflammatory effects, and particularly, the cream prepared by adding the extract of the stress yeast has stronger self-repairing and ultraviolet ray resisting effects.
Claims (10)
1. a preparation process of a traditional Chinese medicine compound extract for whitening and removing freckles is characterized by comprising the following steps:
(1) Preparing a first extracting solution: adding mung beans and mulberry leaves into ethanol, sequentially carrying out ultrasonic extraction and centrifugal treatment, carrying out evaporation concentration on collected supernate, and sequentially carrying out low-temperature cold turbidity and filtration on obtained concentrated solution to obtain a first extracting solution;
(2) Preparing a second extracting solution: adding Glycyrrhrizae radix, Rubi fructus, and radix Angelicae sinensis into purified water, decocting, storing at low temperature, centrifuging, and filtering to obtain second extractive solution;
(3) Preparing a third extracting solution: adding radix Paeoniae alba, rhizoma Bletillae, and Poria into purified water, adding cellulase and pectinase for enzymolysis, sequentially inactivating enzyme, cooling, adding stress yeast or Aspergillus niger for fermentation, sequentially sterilizing, and centrifuging to obtain a third extractive solution;
(4) Dissolving the first extractive solution with alcohol solvent, and mixing with the second extractive solution and the third extractive solution to obtain compound Chinese medicinal extractive solution.
2. The preparation process of the compound traditional Chinese medicine extracting solution for whitening and removing freckles according to claim 1, characterized in that in the step (3), the yeast is cultured for 2h to 5h by ultraviolet irradiation, and then the stress yeast is obtained by expanding culture, freezing and drying.
3. The preparation process of the compound traditional Chinese medicine extracting solution for whitening and removing freckles as claimed in claim 1, wherein in the step (1), the mung beans and the mulberry leaves are added into 70% ethanol according to the dosage of 3-15%.
4. The preparation process of the compound traditional Chinese medicine extracting solution for whitening and removing freckles according to claim 1, wherein in the step (2), the liquorice, the raspberry and the angelica are added into the purified water according to the dosage of 0.5-5%.
5. The preparation process of the compound traditional Chinese medicine extracting solution for whitening and removing freckles according to claim 1, characterized in that in the step (2), the temperature is 4-8 ℃ and the time is 40-60 h when the compound traditional Chinese medicine extracting solution is stored at low temperature.
6. the preparation process of the compound traditional Chinese medicine extracting solution for whitening and removing freckles according to claim 1, wherein in the step (3), the white paeony root, the bletilla striata and the white poria are added into the purified water according to the dosage of 0.5-5%.
7. The preparation process of the compound traditional Chinese medicine extracting solution for whitening and removing freckles according to claim 1, characterized in that in the step (3), the dosage of the cellulase is 0.1-2%, and the dosage of the pectinase is 0.1-2%.
8. The preparation process of the compound traditional Chinese medicine extracting solution for whitening and removing freckles according to claim 1, characterized in that in the step (3), the temperature is 45-55 ℃ and the time is 2-4 h during enzymolysis.
9. The preparation process of the traditional Chinese medicine compound extract for whitening skin and removing freckles according to claim 1, wherein in the step (3), the dosage of the stress yeast or aspergillus niger is 0.1-2%.
10. The application of the traditional Chinese medicine compound extracting solution for whitening and removing freckles according to any one of claims 1 to 9, which is characterized in that the traditional Chinese medicine compound extracting solution is used for preparing a whitening and freckles removing facial cream;
The whitening and freckle-removing facial cream comprises the following raw materials in parts by mass:
5-50 parts of a traditional Chinese medicine compound extracting solution according to any one of claims 1-9;
2-50 parts of purslane extract, 0.5-50 parts of emulsifier, 0.5-50 parts of humectant, 0.5-30 parts of tonic, 0.5-10 parts of thickener, 0.1-5 parts of essence and 1-95 parts of water.
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| CN113304088A (en) * | 2021-05-26 | 2021-08-27 | 上海辉文生物技术股份有限公司 | Preparation method of bletilla striata extract with repairing and whitening effects and bletilla striata extract |
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