KR101373636B1 - Composition for improving condition of skin and scalp containing fermented extracts of herb mixture - Google Patents
Composition for improving condition of skin and scalp containing fermented extracts of herb mixture Download PDFInfo
- Publication number
- KR101373636B1 KR101373636B1 KR1020110141508A KR20110141508A KR101373636B1 KR 101373636 B1 KR101373636 B1 KR 101373636B1 KR 1020110141508 A KR1020110141508 A KR 1020110141508A KR 20110141508 A KR20110141508 A KR 20110141508A KR 101373636 B1 KR101373636 B1 KR 101373636B1
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- South Korea
- Prior art keywords
- skin
- scalp
- extract
- hair
- fermentation
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Abstract
본 발명은 오이풀, 까마중, 소루쟁이, 수세미, 솔잎, 미역, 콩, 산초 및 대나무수액으로 이루어진 천연물 복합 발효 추출물과 그 제조방법, 및 상기 추출물을 유효성분으로 하는 피부 및 두피 상태 개선용 조성물에 관한 것이다.
본 발명은 천연물 유래의 추출물들의 효과로 의해 안전하게 피부자극 없이 피부질환을 개선할 수 있으며, 증상을 일시적으로 개선해주는 것이 아닌 피부가 갖고 있는 고유의 재생능력을 증가시키는데 중점을 둔 근본적인 치료가 가능할 뿐만 아니라 아토피, 알러지, 무좀, 건선, 여드름, 지루성 피부염, 가려움, 탈모방지, 발모촉진, 비듬억제, 두피염증완화 등에 효과가 있어 피부, 모발 및 두피 예방, 치료 및 개선을 위한 피부 치료제, 보습제, 피부세정제, 두피세정제, 비듬치료제, 화장료, 건강기능식품 등에 유용하게 사용될 수 있다.The present invention relates to a natural product complex fermented extract consisting of cucumber grass, yam, sprouts, loofah, pine needles, seaweed, soybean, sancho and bamboo sap, and a preparation method thereof, and a composition for improving skin and scalp condition using the extract as an active ingredient. will be.
The present invention can safely improve skin diseases without skin irritation by the effects of extracts derived from natural products, and not only temporarily improve the symptoms but also fundamental treatment that focuses on increasing the inherent regeneration of the skin. In addition, it is effective in atopic dermatitis, allergy, athlete's foot, psoriasis, acne, seborrheic dermatitis, itching, hair loss prevention, hair growth promotion, dandruff suppression, and scalp inflammation relieving skin, hair and scalp prevention, moisturizer, skin It can be usefully used in detergents, scalp cleaners, dandruff treatments, cosmetics, health foods and the like.
Description
본 발명은 천연물 복합 발효 추출물을 유효성분으로 하는 피부 및 두피 상태 개선용 조성물에 관한 것으로, 더욱 상세하게는, 오이풀, 까마중, 소루쟁이, 수세미, 솔잎, 미역, 콩, 산초 및 대나무수액으로 이루어진 피부 및 두피 상태 개선 효과를 갖는 천연물 복합 발효 추출물과 그 제조방법, 및 상기 추출물을 유효성분으로 하는 피부 및 두피 상태 개선용 조성물에 관한 것이다. The present invention relates to a composition for improving the condition of skin and scalp using the natural complex fermented extract as an active ingredient, and more specifically, the skin consisting of cucumber grass, yam, sprout, loofah, pine needles, seaweed, soybean, sancho and bamboo sap And it relates to a natural product composite fermentation extract having a scalp condition and a method for producing the same, and a composition for improving skin and scalp condition using the extract as an active ingredient.
삶의 질이 높아질수록 현대인들에게는 발생 기전을 알 수 없는 여러 질환들이 나타나는데 그 주요 원인으로는 스트레스와 환경오염을 들 수 있다. 과학문명과 기계문명의 발달이 편리함을 주는 반면 우리의 생존 문제로 연결되어 질병을 얻게 되었고, 면역력도 잃게 된다.As the quality of life gets higher, many diseases appear to be unknown to modern people. The main causes are stress and environmental pollution. While the development of scientific and mechanical civilization is convenient, it leads to our survival problems, which leads to disease and loss of immunity.
현대인의 스트레스는 신체의 리듬을 깨뜨리고 순환계의 문제를 일으켜 건강 상태의 문제를 초래하기도 하며 외형상의 피부에도 부작용으로 나타난다. The stress of the modern man can break the rhythm of the body and cause problems of the circulatory system, which can lead to the problem of the state of health, and also appear as a side effect on the appearance of the skin.
피부염이나 두피염증은 각종 오염물질, 세균에 대한 피부의 이상과민 반응, 내분비계 이상, 자율신경계 이상, 혈액순환장애 등 순환계 이상에 의한 과도한 피지생성, 모근의 영양결핍, 알레르기, 세균감염 등의 신체적 요인과, 호르몬의 영향 등의 유전적 요인과, 각종 공해, 가공식품이 주류인 음식물, 샴푸, 비누, 무스, 헤어젤, 헤어스프레이, 퍼머, 염색, 헤어드라이어, 세제 사용 등 환경적 요인 및 과도한 스트레스를 자주 받는 현대인의 정신적, 사회적 요인, 노화 등이 복합적으로 작용하여 나타나는 것으로 알려져 있다. 또한, 최근에는 남녀노소를 불문하고 각종 피부질환 현상이 증가하고 있다.Dermatitis or scalp inflammation is caused by physical problems such as excessive sebum production due to abnormal sensitization of skin to various contaminants, bacteria, endocrine system, autonomic nervous system disorders, circulatory disorders such as blood circulation disorders, malnutrition of hair roots, allergies, bacterial infections, etc. Factors, genetic factors such as hormonal effects, environmental factors such as the use of various pollutions and processed foods, shampoos, soaps, mousses, hair gels, hairsprays, perms, dyes, hair dryers and detergents It is known that the psychological, social factors, and aging of modern people who are frequently stressed appear in combination. In recent years, various skin diseases have been increasing regardless of age or gender.
이러한 피부나 두피질환 현상의 치료 방법으로는 국소 도포제, 경구 복용제, 건강보조식품, 주사 약물치료 방법이 시행되고 있다. 그러나, 상기와 같은 방법들은 사용범위가 한정되어 있고, 반복적인 피부염이나 두피질환으로 인해 만성질환으로 발전할 수 있으며, 약물 치료의 효과도 일시적인 경우가 많다.Topical coatings, oral dosages, dietary supplements, and injection drug treatments are being used to treat such skin or scalp diseases. However, the methods described above are limited in scope of use, and may develop into chronic diseases due to repetitive dermatitis or scalp diseases, and the effects of drug treatment are often temporary.
또한, 피부질환의 경우에는 내성이 생겨 치료가 어렵고, 두피는 피지의 생성을 오히려 가속화시키며, 피부질환이 특히 심장질환자에는 나쁜 영향을 미치는 등의 부작용을 수반하는 폐단이 있었다.In addition, in the case of skin diseases, resistance is difficult to treat, scalp rather accelerates the production of sebum, and skin diseases, especially heart disease patients with adverse effects such as adverse effects such as adverse effects.
결국, 본 발명은 상기와 같은 문제점을 해결하기 위하여 안출된 것으로, 본 발명의 주된 목적은 피부 및 두피의 염증 예방 효과가 있을 뿐 아니라 피부 및 두피 상태를 개선할 수 있는 천연물 복합 발효 추출물을 유효성분으로 하는 피부 및 두피 상태 개선용 조성물을 제공하는데 있다.After all, the present invention was devised to solve the above problems, the main object of the present invention is not only the effect of preventing the inflammation of the skin and scalp, but also a natural complex fermented extract that can improve the skin and scalp condition active ingredient It is to provide a composition for improving skin and scalp conditions.
상기 목적을 달성하기 위하여, 본 발명은 피부 및 두피 상태 개선 효과를 갖는 천연물 복합 발효 추출물을 제공한다.In order to achieve the above object, the present invention provides a natural product complex fermentation extract having an effect of improving the skin and scalp condition.
본 발명에 있어서, 상기 천연물 복합 발효 추출물은 오이풀, 까마중, 소루쟁이, 수세미, 솔잎, 미역, 콩, 산초, 및 대나무수액에서 선택되는 어느 하나 이상을 혼합하여 물, 탄소수 1 내지 4의 저급 알코올 또는 이들의 혼합용매로 추출한 후, 그 추출물에 젖산균 또는 효모를 접종하여 발효된 것을 특징으로 하며, 이때 상기 오이풀, 까마중, 소루쟁이, 수세미, 솔잎, 미역, 콩, 산초, 및 대나무수액은 각각 1~30 : 1~10 : 1~10 : 1~10 : 1~30 : 1~10 : 1~10 : 1~10 : 1~10의 중량비로 혼합되는 것이 좋다.In the present invention, the natural product complex fermentation extract is mixed with any one or more selected from cucumber grass, walrus, russetula, loofah, pine needles, seaweed, soybean, sancho, and bamboo sap, water, lower alcohol having 1 to 4 carbon atoms or After extracting them with a mixed solvent, the extract is fermented by inoculating lactic acid bacteria or yeast, characterized in that the cucumber grass, black yam, russetula, loofah, pine needles, seaweed, soybeans, sancho, and bamboo sap each 1 ~ 30: 1 ~ 10: 1 ~ 10: 1 ~ 10: 1 ~ 30: 1 ~ 10: 1 ~ 10: 1 ~ 10: It is good to mix in a weight ratio of 1 to 10.
또한, 본 발명은 상기 천연물 복합 발효 추출물의 제조방법을 제공한다.In addition, the present invention provides a method for producing the natural product complex fermentation extract.
또한, 본 발명은 상기 천연물 복합 발효 추출물을 유효성분으로 하는 피부 및 두피 상태 개선용 조성물을 제공한다.
The present invention also provides a composition for improving skin and scalp conditions using the natural product complex fermentation extract as an active ingredient.
참고로, 본 출원은 대구테크노파크 한방지원센타 기술지원사업으로 수행되었다.For reference, this application was performed as a technical support project of Daegu Techno Park Hanban One Center.
상기와 같은 본 발명에 따르면, 천연물 유래의 추출물들의 효과로 의해 안전하게 피부자극 없이 피부질환을 개선할 수 있으며, 염증, 가려움 등을 세포 재생으로 완화하여 피부의 과민반응을 안정시킬 수 있으므로 증상을 일시적으로 개선해주는 것이 아닌 피부가 갖고 있는 고유의 재생능력을 증가시키는데 중점을 둔 근본적인 치료가 가능하다.According to the present invention as described above, the effects of extracts derived from natural products can safely improve the skin disease without skin irritation, and to relieve inflammation, itching, etc. by cell regeneration to stabilize the skin hypersensitivity reactions, so symptoms are temporarily Rather than improving it, it is possible to treat the fundamental treatment that focuses on increasing the natural regeneration of the skin.
또한, 본 발명의 천연물 복합 발효 추출물은 아토피, 알러지, 무좀, 건선, 여드름, 지루성 피부염, 가려움, 탈모방지, 발모촉진, 비듬억제, 두피염증완화 등에 효과가 있어 피부, 모발 및 두피 예방, 치료 및 개선을 위한 피부 치료제, 보습제, 피부세정제, 두피세정제, 비듬치료제, 화장료, 건강기능식품 등에 유용하게 사용될 수 있다.In addition, the natural complex fermented extract of the present invention is effective in preventing atopic dermatitis, allergy, athlete's foot, psoriasis, acne, seborrheic dermatitis, itching, hair loss, hair growth, dandruff suppression, scalp inflammation, skin, hair and scalp prevention, treatment and It can be usefully used for skin treatments, moisturizers, skin cleaners, scalp cleaners, dandruff treatments, cosmetics, health foods for improvement.
도 1은 손에 피부염 증세를 가진 실험 대상자에게 본 발명의 천연물 복합 발효 추출물을 사용하기 전과 사용 3개월 후의 상태를 보여주는 사진이다.
도 2는 지루성 탈모 증세를 가진 실험 대상자에게 본 발명의 천연물 복합 발효 추출물을 사용하기 전과 사용 3개월 후의 상태를 보여주는 사진이다.
도 3은 알러지 증세로 병원입원 중인 실험 대상자에게 본 발명의 천연물 복합 발효 추출물을 사용하기 전과 사용 1개월 및 3개월 후의 상태를 보여주는 사진이다.1 is a photograph showing the state before and after 3 months of use of the natural product complex fermentation extract of the present invention to the test subjects with symptoms of dermatitis in the hand.
Figure 2 is a photograph showing the state before and after 3 months of use of the natural product complex fermentation extract of the present invention to subjects with seborrheic alopecia.
Figure 3 is a photograph showing the state before and after using the natural compound fermented extract of the present invention 1 month and 3 months to test subjects who are hospitalized with allergic symptoms.
이하, 본 발명을 상세히 설명한다.Hereinafter, the present invention will be described in detail.
본 발명은 피부 및 두피 상태 개선 효과를 갖는 천연물에서 유래한 복합 발효 추출물을 제공한다.The present invention provides a complex fermentation extract derived from natural products having an effect of improving skin and scalp conditions.
본 발명에서, 상기 천연물 복합 발효 추출물은, 오이풀, 까마중, 소루쟁이, 수세미, 솔잎, 미역, 콩, 산초, 및 대나무수액에서 선택되는 어느 하나 이상인 것이 바람직하며, 상기 오이풀, 까마중, 소루쟁이, 수세미, 솔잎, 미역, 콩, 산초, 및 대나무수액은 각각 1~30 : 1~10 : 1~10 : 1~10 : 1~30 : 1~10 : 1~10 : 1~10 : 1~10의 중량비로 혼합하여 사용할 때 최적의 효과를 나타낸다. In the present invention, the natural product complex fermentation extract is preferably any one or more selected from cucumber grass, black seaweed, scallop, loofah, pine needles, seaweed, soybeans, sancho, and bamboo sap, the cucumber grass, black seaweed, slush, loofah , Pine needles, seaweed, soybeans, sancho, and bamboo sap respectively 1-30: 1-10: 1-10: 1-10: 1-30: 1-10: 1-10: 1-10: 1-10 Optimum effect is obtained when mixed in weight ratio.
상기와 같이 선택된 시료는 분말화한 후 시료 중량의 약 1 내지 20배, 바람직하게는 5 내지 15배의 물, 탄소수 1 내지 4의 저급 알코올 또는 이들의 혼합용매, 바람직하게는 물로 35 내지 120℃, 바람직하게는 95 내지 100℃에서 약 0.1 내지 48시간, 바람직하게는 1 내지 24시간 동안 교반추출, 열수추출, 냉침추출, 가온추출, 환류냉각추출 또는 초음파 추출 등의 추출방법을 사용하여, 바람직하게는 열수추출한 후, 수득한 추출액을 여과, 감암농축 또는 건조하여 추출물을 얻을 수 있다.
The sample selected as above is about 1 to 20 times the powder weight, preferably 5 to 15 times water, lower alcohol having 1 to 4 carbon atoms or a mixed solvent thereof, preferably 35 to 120 ° C. after powdering. Preferably, using an extraction method such as stirring extraction, hot water extraction, cold extraction, warm extraction, reflux cooling extraction or ultrasonic extraction for about 0.1 to 48 hours, preferably 1 to 24 hours at 95 to 100 ℃ Preferably, after extracting hot water, the obtained extract is filtered, concentrated or dried to obtain an extract.
본 발명에서 상기 '추출물'은 추출액, 정제물, 희석액, 농축액, 및 건조물을 모두 포함하여, 상기와 같이 얻어진 추출물은 젖산균 및 효모 중 하나 이상을 접종하여 30~50℃에서 24~72시간을 발효시키는 것이 바람직하다.
In the present invention, the 'extract' includes all extracts, purified products, diluents, concentrates, and dried products, the extract obtained as described above is inoculated at least one of lactic acid bacteria and yeast fermented at 24 ~ 72 hours at 30 ~ 50 ℃ It is preferable to make it.
본 발명에서 사용가능한 젖산균은 락토바실루스속 젖산균(Lactobacillus sp.), 스트렙토코쿠스속 젖산균(Streptococcus sp.), 페디오코쿠스속 젖산균(Pediococcus sp.), 류코노스톡속 젖산균(Leuconostoc sp.) 및 비피도박테리움속 젖산균(Bifidobacterium sp.)으로 구성된 군에서 선택되는 하나 이상의 균주일 수 있다. 또한, 상기 효모에는 사카로마이세스 세레비시아에(Saccharomyces sereviciae), 사카로마이세스 루시(Saccharomyces rouxii), 사카로마이세스 오비폴미스(Saccharomyces oviformis), 사카로마이세스 스테이네리(Saccharomyces steineri) 등이 포함된다. 바람직하게는 상기 젖산균으로 락토바실러스 파라카세이(Lactobacillus paracasei)를 사용하는 것이 좋다. Lactic acid bacteria that can be used in the present invention is Lactobacillus genus of lactic acid bacteria (Lactobacillus sp.), Streptococcus genus of lactic acid bacteria (Streptococcus sp.), Phedi OKO kusu in lactic acid bacteria (Pediococcus sp.), Flow Pocono stock in lactic acid (Leuconostoc sp.) And It may be one or more strains selected from the group consisting of Bifidobacterium sp. In addition, the yeast includes Saccharomyces sereviciae , Saccharomyces rouxii , Saccharomyces oviformis , Saccharomyces steineri Etc. are included. Preferably, Lactobacillus paracasei may be used as the lactic acid bacterium.
그러나, 상기 균주나 효모의 종류는 본 발명에 따른 조성물이 피부 외용제 등의 형태로 인체에 직접 적용, 도포되므로 인체 안정성과 발효력을 고려하여 선택된 것으로, 인체 안정성 및 발효력이 인정되는 한 당업계에서 사용되는 어떠한 균주나 효모도 사용될 수 있으며, 본 발명은 상기 젖산균 및 효모의 종류에 한정되지 않는다.
However, the type of the strain or yeast is selected in consideration of the human stability and fermentation power, so that the composition according to the present invention is applied directly to the human body in the form of external preparations for skin, etc., used in the art as long as human stability and fermentation power are recognized. Any strain or yeast may be used, the present invention is not limited to the type of lactic acid bacteria and yeast.
또한, 본 발명에서 '피부 및 두피 상태 개선'은 심한 흉터를 제외한 당업계에서 피부 및 두피 질환 혹은 증상으로 분류되는 모든 피부, 두피 및 모발의 상태 개선을 의미하며, 바람직하게는 아토피 피부염, 알러지성 피부염, 화상, 무좀, 접촉성 피부염, 비듬, 원형탈모증, 지루성 피부염, 건선 등의 피부염이나 두피염증, 여성원형탈모, 소아원형탈모를 동반하는 지루성 탈모 중 어느 하나 이상의 피부 및 두피 질환 혹은 증상의 치료 및 개선을 포함한다.
In addition, the term 'improvement of skin and scalp' in the present invention means improvement of the condition of all skin, scalp and hair classified as skin and scalp disease or symptom in the art except severe scars, preferably atopic dermatitis, allergic Treatment of skin and scalp diseases or symptoms of one or more of dermatitis, burns, athlete's foot, contact dermatitis, dandruff, alopecia areata, seborrheic dermatitis, psoriasis, or scleroderma, female alopecia, and pediatric alopecia And improvements.
본 발명에서 사용되는 오이풀(Sanguisorba officinalis L)은, 장미과에 속하는 여러해살이풀로, 식물체에서 향긋한 오이냄새가 난다하여 붙여진 이름이다. 보통은 뿌리를 약으로 쓰며, 수렴, 해열, 설사, 이질, 지혈, 월경과다, 객혈, 피부병, 상처 및 화상과 열상 등에 사용된다. 또한, 뿌리에는 17%의 타닌과 사포닌이 함유되어 있으며, 잎에는 탄수화물, 단백질, 지방, 무기질, 칼슘, 철, 구리, 아연 등의 미량 원소가 많이 들어있어 상큼한 오이향과 함께 영양가도 풍부해 나물이나 생즙으로 먹으면 좋다.
Cucumber (Sanguisorba officinalis L) used in the present invention is a perennial herb belonging to the family Rosaceae, and is named after the smell of cucumbers in plants. Usually, the root is used as a medicine, and it is used for convergence, fever, diarrhea, dysentery, hemostasis, excessive menstruation, hemoptysis, skin disease, wounds and burns and lacerations. In addition, the root contains 17% of tannins and saponins, and the leaves contain a lot of trace elements such as carbohydrates, proteins, fats, minerals, calcium, iron, copper, and zinc. It is good to eat with fresh juice.
또한, 까마중(Solanum nigrum L)은 가지과에 따린 한해살이풀로, 여름철에 조그맣고 하얀 꽃이 피어 가을에 콩알만 한 열매가 까맣게 익는다. 열매에 즙이 많아 아이들이 따먹기도 하고, 어린잎은 나물로도 먹는다. 이러한 까마중은 오래 전부터 옹종, 종기, 악창을 치료하는 약으로 흔히 사용되었으며, '당본초', '도경본초', '본초강목'과 같은 옛 중국의학책에는 까마중이 열을 내리고 오줌을 잘나가게 하고 원기를 도와주며 잠을 적게 자게하고, 옹저와 종기로 인한 독과 타박상, 어혈을 다스리며, 갖가지 광석물의 독을 푸는 작용이 있다고 적혀있다. 또한, 까마중은 항암작용이 매우 센 약초 중 하나로 암치료제로 널리 사용되기도 하며, 염증을 없애고 온갖 균을 죽이며 기침을 멎게 하고 몸 안에 쌓인 독을 풀어준다. 또한, 열매에 들어있는 아트로핀 성분은 눈동자를 크게 하므로 안구조절근육이 마비되어 생기는 근시환자에게 도움이 된다.
In addition, Solanum nigrum L is an annual herb that is accorded to the branch family, and small white flowers bloom in summer and ripe in the fall. The fruit is succulent, so children eat and young leaves are eaten as herbs. These crows have long been commonly used as medicines for treating carbuncles, boils and spears.In ancient Chinese medicine books such as `` Tangbon Herb '', `` Tokyo Herb '', and `` Horum Herb '', the crow middle heats up and peees well. It is said to help rejuvenate, sleep less, control poisons, bruises, fish blood, and detoxify various minerals. It is also one of the strongest anti-cancer medicines and is widely used as a cancer treatment. It removes inflammation, kills all kinds of bacteria, stops coughing, and releases the poison accumulated in the body. In addition, the atropine component contained in the fruit makes the pupils larger, which helps myopia patients caused by paralysis of the ocular osteotomy muscles.
또한, 소루쟁이(Rumex crispus L)는 다른 이름으로 솔쟁이, 송구지라고도 하며, 어린잎은 나물로 먹기도 한다. 또한, 백선, 무좀, 습진 등에 효과가 있으며, 예부터 민간에서는 개선, 옴, 피부암 등의 피부병에 사용했으며, 방광염, 대장염 등에도 달여서 사용했다. 가을에 뿌리를 캐서 둥글게 말아 햇볕에 말린 것을 양제근이라고 하며, 이를 대황이라는 약재 대용으로 사용한다. 다량 복용하면 설사 등의 부작용을 유발한다.
In addition, Rumex crispus L is another name also known as solbanggi, songguji, young leaves are also eaten as herbs. In addition, it is effective in ringworm, athlete's foot, eczema, etc. Since ancient times, it has been used in the general public for skin diseases such as improvement, scabies and skin cancer. The roots are cut in the autumn and dried in the sun, which is called Yangje-geun, and it is used as a substitute for rhubarb. High doses can cause side effects such as diarrhea.
또한, 수세미(Luffa cylindrica R)은 비염 개선하고, 모유를 잘 돌게 하며, 오십견, 장염 등을 예방하고, 아토피, 피부습진 등에 효과가 있는 것으로 알려져 있다.
In addition, scrub (Luffa cylindrica R) is known to be effective in improving rhinitis, making breast milk well, preventing fifty shoulders, enteritis, and atopic dermatitis.
또한, 솔잎(Pinus densflora)에는 특히 당질이 많이 들어 있으며, 단백질, 지방질, 칼슘, 인, 철분, 비타민 A, C 등이 있다. 솔잎은 체내의 콜레스테롤 수치를 내리고, 말초신경을 확장시켜 호르몬의 분비를 높이는 등 몸의 조직을 일깨워주는 역할을 하므로 고혈압, 심근경색 등에 효과적이며, 신경을 안정시키는 효과가 있고, 감기 예방과 치료에도 큰 도움을 준다. 또한, 솔잎에는 혈장을 낮춰주는 성분인 글리코키닌도 포함하고 있어 당뇨병에 도움을 주며, 비타민 C와 철분이 풍부해 빈혈에도 좋다. 또한, 한방에서는 타박상, 불면, 부종, 피부질환 등에서 사용한다.
In addition, pine needles (Pinus densflora) contains a lot of sugar, especially protein, fat, calcium, phosphorus, iron, vitamins A, C and the like. Pine needles lower the cholesterol levels in the body and expand the peripheral nerves to increase the secretion of hormones, thereby stimulating the body's tissues.It is effective in hypertension, myocardial infarction, and stabilizes nerves. Great help In addition, pine needles contain glycokinin, a substance that lowers plasma, which helps diabetes, and is rich in vitamin C and iron, which is good for anemia. It is also used in bruises, insomnia, edema, and skin diseases.
또한, 미역(Undaria pinnatifida Harvey Suringar)은 강알카리성 식품으로 칼슘이 다량 함유되어 있으며, 알긴산, 라미나린, 후코이단, 포크스테롤, 엽록소, EPA(eicosapentaenoic acid), DHA(Docosa Hexaenoic Acid), 리놀산, 비타민 A, B1, B2 및 만니톨이 풍부하다. 혈압을 부작용 없이 뚜렷하게 낮추어주는 강압제로 널리 사용되며, 항암작용, 항응혈 작용, 해독 작용을 하는 것으로 알려져 있다.
In addition, seaweed (Undaria pinnatifida Harvey Suringar) is a strong alkaline food containing a large amount of calcium, alginic acid, laminarin, fucoidan, folksterol, chlorophyll, EPA (eicosapentaenoic acid), DHA (Docosa Hexaenoic Acid), linoleic acid, vitamin A Is rich in B1, B2 and mannitol. It is widely used as a coercive agent to lower blood pressure without any side effect and is known to have anticancer action, anticoagulant action and detoxification effect.
또한, 콩(Fabaceae)은 식량으로서 뿐만 아닐 건강식품으로서도 그 효능이 뛰어난 것으로 평가되고 있는데, 성인병을 예방하고, 혈액순환촉진 및 호르몬의 균형을 유지하는 역할을 한다. 또한, 콩에는 항암효과가 있으며, '동의보감'에서는 콩을 장기간 복용하면 보신효과가 있고, 체중이 증가하며, 위장의 열을 제거하고 장의 통증, 열독에 효과가 있으며, 대소변의 배설을 다스리고, 부종, 복부팽만 등에 효과가 있다고 하였다. 한편, 콩카루도 뱃속과 장을 다스리며, 곡물의 소화를 돕고 종기를 제거하는 효과가 있으며, 콩나물은 무릎의 동통을 다스리고 근육통을 없애준다고 하였다.
In addition, the beans (Fabaceae) is evaluated as an excellent effect not only as food, but also as a health food, it plays a role in preventing adult diseases, promoting blood circulation and maintaining the balance of hormones. In addition, the beans have an anti-cancer effect, in the 'consent bogam' the long-term use of soybeans have the effect of seeing, gaining weight, removing the heat of the stomach, intestinal pain, heat poisoning, control the excretion of urine, edema And abdominal bloating. On the other hand, kongkaru also controls the stomach and intestines, helps to digest grains and removes boils, and bean sprouts are said to control knee pain and eliminate muscle pain.
또한, 산초(Zanthoxylum schinifolium Siebold)는 천초, 향초자, 야초, 항초유, 분지나무, 분디나무, 민산초나무, 상초, 애초 등으로 불리기도 하며, 우리나라에서는 어린줄기와 새싹 잎을 덜 익은 과실과 함께 장채(醬彩)를 하여 먹었으며, 과실은 짜내어 점등료(點燈料) 및 향미료(香味料)로 널리 쓰인다. 유선염과 종기, 타박상, 치질, 두통, 기침에 효과가 있고, 사지슬통(四肢膝痛)을 제거하며, 풍한습비(風寒濕痺)에도 좋다. 또한, 고혈압, 항암, 강장, 모세혈관확장 등에 효과가 있다.
In addition, Sancho (Zanthoxylum schinifolium Siebold) is also called cheoncho, herb, Yacho, Hangcho oil, branch tree, Bundi tree, hyacinth, vinegar, inflorescence, etc. It is eaten together with jangchae, and the fruit is squeezed out and is widely used as lighting and flavoring. It is effective for mastitis and boils, bruises, hemorrhoids, headaches and coughs, eliminating extremity pain (四肢 膝痛), is also good for wind and wet rain (風 寒濕 痺). In addition, it is effective in hypertension, anticancer, tonic, capillary expansion and the like.
대나무는 수액보다는 줄기, 표피, 죽순 및 죽실 등이 질병 치료제로 사용되었으나, 대나무수액(Bam busoideae)은 건위, 이뇨, 신경안정 및 심장질환의 발생 억제 등에 효능이 있는 것으로 알려져 있다.Bamboo, stem, epidermis, bamboo shoots, and bamboo shoots were used for the treatment of diseases, but bamboo sap (Bam busoideae) is known to be effective in suppressing the occurrence of dry stomach, diuresis, neurostable and heart disease.
본 발명은 또한 상기 천연물에서 유래한 복합 발효 추출물을 유효성분으로 하는 피부 및 두피 상태 개선용 조성물을 제공한다.The present invention also provides a composition for improving skin and scalp condition using the complex fermented extract derived from the natural product as an active ingredient.
또한, 본 발명의 조성물은 상기 천연물 발효 추출물을 피부 및 두피의 증상 정도나 사용 용도에 따라 인체에의 독성을 미치지 않는 범위 내에서 임의의 양으로 포함할 수 있는데, 구체적으로 조성물 전체 중량을 기준으로 0.001 내지 99.99중량%로 포함할 수 있으며, 바람직하게는 0.1 내지 50중량%로 포함하는 것이 좋다.In addition, the composition of the present invention may include the natural product fermentation extract in any amount within the range that does not have toxicity to the human body depending on the degree of symptoms and use of the skin and scalp, specifically based on the total weight of the composition It may be included in 0.001 to 99.99% by weight, preferably 0.1 to 50% by weight.
또한, 본 발명의 조성물은 약제학적 또는 화장학적으로 허용되는 담체를 추가로 함유하며, 크림, 로션, 토닉, 스프레이, 에어로졸, 오일, 용액, 현탁액, 젤, 연고, 에멀젼, 참제, 페이스트 등의 통상적인 제형으로 제조될 수 있다. 본 발명의 조성물은 통상의 기제를 함유하고, 필요에 따라서 일반적으로 약품 또는 화장품 원료로서 사용되는 기타 성분이 적절히 배합될 수 있다.In addition, the compositions of the present invention further contain a pharmaceutically or cosmetically acceptable carrier, and include conventional creams, lotions, tonics, sprays, aerosols, oils, solutions, suspensions, gels, ointments, emulsions, sesame seeds, pastes and the like. It may be prepared in a phosphorus formulation. The composition of this invention contains a conventional base, and the other component generally used as a pharmaceutical or cosmetic raw material can be mix | blended suitably as needed.
본 발명의 조성물의 기제는 통상적으로 사용되는 한 어떠한 것도 사용가능하며, 그 예로 정제수, 미네랄워터, 에탄올, 글리세린, 스쿠알렌, 1,3-프로필렌글리콜, 1,3-부틸렌글리콜, 피마자유, 츠바키유 및 리퀴드 페트롤레이텀(liquid petrolatum)을 포함한다. 본 발명의 조성물에 배합되는 기타 성분의 예는 계면활성제, 유화제, 증점제, 방부제(예를 들어, 파라옥시안식향산메틸), 산화방지제, 향료 등을 포함하며 이에 한정되지는 않는다.The base of the composition of the present invention can be used as long as it is commonly used, such as purified water, mineral water, ethanol, glycerin, squalene, 1,3-propylene glycol, 1,3-butylene glycol, castor oil, Tsubaki Oils and liquid petrolatum. Examples of other components to be incorporated into the compositions of the present invention include, but are not limited to, surfactants, emulsifiers, thickeners, preservatives (eg, methyl paraoxybenzoate), antioxidants, fragrances, and the like.
본 발명의 조성물에는 상기 성분 이외에도 모낭에 영영소를 공급하는 역할을 할 수 있는 성분이나 통상적으로 사용되는 모발성장 촉진 보조성분을 포함할 수 있는데, 예를 들면 비타민류, 아미노산류, 동식물유, 염화나트륨 등을 포함하지만 이들로 한정되는 것은 아니다. 이들의 양은 전체 조성물의 0.0001 내지 10중량%, 바람직하게는 0.01 내지 1중량%로 첨가되는 것이 좋다. 이때, 비타민류는 비타민 A, 비타민 B1, 비타민 B2, 나이아신(니코틴산), 비타민 C, 비타민 E, 판토텐산 나트륨, 판토텐산 칼륨, 비오틴 H(비타민 H) 등을 모두 포함하지만 이들로 한정되는 것은 아니며, 아미노산류는 도파를 포함하나 이에 한정되는 것은 아니다. 또한, 동식물유는 마유, 난유, 올리브유, 동백유, 유채기름, 참기름, 배아유 등을 포함하지만 이들로 한정되는 것은 아니다.In addition to the above components, the composition of the present invention may include components that may serve to supply nutrients to hair follicles or hair growth promoting auxiliary components that are commonly used. For example, vitamins, amino acids, animal and vegetable oils, sodium chloride And the like, but are not limited thereto. These amounts are preferably added at 0.0001 to 10% by weight, preferably 0.01 to 1% by weight of the total composition. In this case, the vitamins include all but not limited to vitamin A, vitamin B1, vitamin B2, niacin (nicotinic acid), vitamin C, vitamin E, sodium pantothenate, potassium pantothenate, biotin H (vitamin H), and the like, amino acids The class includes, but is not limited to, waveguides. In addition, animal and vegetable oils include, but are not limited to, horse oil, egg oil, olive oil, camellia oil, rapeseed oil, sesame oil, germ oil, and the like.
본 발명의 조성물은 피부, 모발 및 두피에 직접 도포 또는 산포하는 등의 방법에 의해 사용될 수 있다. The compositions of the present invention can be used by methods such as direct application or spreading on the skin, hair and scalp.
본 발명에서 '모발'이란, 머리의 모근 및 모낭, 머리카락 및 속눈썹과 겉눈썹, 수염, 겨드랑이, 음모, 신체 전반에 모근 및 모낭이 있는 모든 부위를 포함한다. 따라서, 본 발명은 헤어토닉, 헤어로션, 헤어크림, 헤어스프레이, 헤어무스, 헤어젤, 헤어컨디셔너, 헤어샴푸, 헤어린스, 헤어팩, 헤어트리트먼트, 눈썹발모제, 속눈썹발모제 또는 속눈썹영양제, 또는 애완동물용 샴푸 및 애완동물용 린스로 사용될 수 있다.
In the present invention, the term "hair" includes hair follicles and hair follicles of hair, hair and eyelashes, and eyelashes, beards, armpits, pubic hair, and all parts having hair roots and hair follicles throughout the body. Accordingly, the present invention provides hair tonics, hair lotions, hair creams, hair sprays, hair mousses, hair gels, hair conditioners, hair shampoos, hair rinses, hair packs, hair treatments, eyebrow regrowths, eyelash regrowths or eyelash nutrients, or pets. It can be used as a shampoo and pet rinse.
본 발명에 따른 조성물의 용량은 성별, 연령, 증상, 피부 및 두피 상태 등을 고려하여 적절히 결정되어야 한다. 바람직하게는 성인을 기준하여 1일 추출물 3~15 ㏄으로 1~5회 적용될 수 있다. The dosage of the composition according to the present invention should be appropriately determined in consideration of sex, age, symptoms, skin and scalp conditions, and the like. Preferably it can be applied 1 to 5 times 3 ~ 15 추출물 1 day extract based on the adult.
본 발명의 조성물을 가장 난치성이라고 하는 피부염 환자에게 도포하는 경우, 1~4주가 경과하면 피부염이 현저하게 감소하며, 4~12주 후부터는 거의 정상인의 수준으로 돌아왔다.When the composition of the present invention is applied to a patient with the most refractory dermatitis, dermatitis is remarkably reduced after 1 to 4 weeks, and returned to almost normal level after 4 to 12 weeks.
또한, 비듬균 지루성 피부염에 대해서도 살균효과가 탁월하여, 지루성 탈모증세가 있는 환자에게 도포한 결과, 3개월 후에는 세포재생 효과로 두피 개선과 동시에 탈모도 완치됨을 확인할 수 있었다. 따라서, 본 발명의 조성물은 탈모방지제, 발모촉진제, 육모제, 두피세정제, 비듬치료제 등에 사용 가능하다.
In addition, the bactericidal effect was also excellent against dandruff seborrheic dermatitis, and when applied to a patient with seborrheic alopecia, it was confirmed that after 3 months, the hair regeneration was simultaneously improved and the hair loss was cured. Therefore, the composition of the present invention can be used for hair loss preventing agent, hair growth promoting agent, hair growth agent, scalp cleaner, dandruff treatment agent and the like.
이하, 실시예를 통하여 본 발명을 더욱 상세히 설명하고자 한다. 이들 실시예는 오로지 본 발명을 예시하기 위한 것으로서, 본 발명의 범위가 이들 실시예에 의해 제한되는 것으로 해석되지는 않는 것은 당업계에서 통상의 지식을 가진 자에게 있어서 자명할 것이다.Hereinafter, the present invention will be described in more detail with reference to Examples. It is to be understood by those skilled in the art that these examples are for illustrative purposes only and that the scope of the present invention is not construed as being limited by these examples.
실시예. 천연물에서 유래한 복합 발효 추출물 제조Examples. Preparation of complex fermented extract derived from natural products
시중에서 구입한 오이풀, 까마중, 소루쟁이, 수세미, 솔잎, 미역, 콩, 산초 및 대나무수액을 잘 건조시켜 멸균 후 각각을 분말화 하여 10 : 5 : 5 : 5 : 10 : 5 : 5 : 3 : 2의 중량비로 혼합한 다음, 혼합 분말에서 500 g을 취하여 여기에 물 6 ℓ을 넣은 후 95~100℃에서 24시간 동안 추출하였다. Cucumbers, black walnuts, scallops, scrubbers, pine needles, seaweed, soybeans, sancho and bamboo sap, which are commercially available, are sterilized well and then each powdered and then sterilized 10: 5: 5: 5: 10: 5: 5: 3: After mixing at a weight ratio of 2, 500 g was taken from the mixed powder, and 6 L of water was added thereto, followed by extraction at 95 to 100 ° C for 24 hours.
상기 추출액은 여과 후 멸균하고, 상기 멸균된 추출액에 젖산균(Lactobacillus paracasei KW3110)을 추출액 100 ㎎당 균주 10 ㎎의 농도로 첨가하여 35~40℃를 유지하면서 72시간(3일) 동안 발효시켜 천연물 발효 추출물을 제조하였다.
The extract was sterilized after filtration, and fermented for 72 hours (3 days) while maintaining 35-40 ° C. by adding lactic acid bacteria ( Lactobacillus paracasei KW3110) to the sterilized extract at a concentration of 10 mg strain per 100 mg of extract. An extract was prepared.
실험예 1. 피부 상태 개선 확인(1)Experimental Example 1. Confirmation of improvement of skin condition (1)
손에 피부염 증세를 가진 11명을 대상으로 1일 3~5회 상기 실시예에서 제조한 천연물 복합 발효 추출물을 1회당 3 ㏄ 정도로 하여 하루 총 9~15 ㏄를 골고루 발라 두드리는 방법으로 최초 1개월에서 3개월간 사용한 후 결과를 관찰하였다.
For 11 people with symptoms of dermatitis on their hands, 3 ~ 5 times a day of the natural product complex fermentation extract of about 3 하여 per time, and evenly spreading a total of 9 ~ 15 하루 a day by tapping the first month The results were observed after 3 months of use.
실험예 2. 두피 상태 개선 확인Experimental Example 2. Confirmation of improvement of scalp condition
지루성 탈모증세가 심한 사람 20명을 대상으로 1회 3 ㏄ 사용으로 1일 3~5회 샴푸 후 타월드라이하고, 상기 실시예에서 제조한 천연물 복합 발효 추출물을 탈모가 진행된 두피에 9~15 ㏄를 골고루 바르고 마사지 하는 방법으로 최초 1개월에서 3개월간 사용한 후 결과를 관찰하였다.
To 20 people with severe seborrheic alopecia, towel dry after shampooing 3 to 5 times a day using 3 ㏄ once a day, and evenly spread the scalp from 9 to 15 에 evenly on the scalp where the natural product fermentation extract prepared in Example After the first one to three months using a method of massage and massage, the results were observed.
실험예 3. 피부 상태 개선 확인(2)Experimental Example 3. Confirmation of improvement of skin condition (2)
병원에 알러지 증세로 입원 중인 환자 17명을 대상으로 상기 실시예에서 제조한 천연물 복합 발효 추출물을 1회당 3 ㏄ 사용으로 1일 3~5회 9~15 ㏄의 양으로 골고루 발라 두드리는 방법으로 최초 1개월에서 3개월간 사용한 후 결과를 관찰하였다.
For 17 patients hospitalized with allergies to the hospital, the natural product complex fermentation extract prepared in the above example was used by tapping evenly in an amount of 9-15 회 3 to 5 times a day by using 3 당 per dose. The results were observed after 3 months of use.
그 결과, 도 1 내지 도 3에서 나타난 바와 같이, 모든 실험대상자에서 증세가 현저히 줄어들면서 피부 및 두피 상태 개선효과가 확인되었으며, 피부자극이나 부작용은 실험기간 동안 전혀 없었다.
As a result, as shown in Figures 1 to 3, all the subjects were significantly reduced symptoms and skin and scalp condition improvement effect was confirmed, there was no skin irritation or side effects during the experiment.
이상, 본 발명의 내용의 특정한 부분을 상세히 기술하였는바, 당업계의 통상의 지식을 가진 자에게 있어서, 이러한 구체적인 기술은 단지 바람직한 실시양태일 뿐이며, 이에 의해 본 발명의 범위가 제한되는 것이 아닌 점은 명백할 것이다. 따라서, 본 발명의 실질적인 범위는 첨부된 청구항들과 그것들의 등가물에 의하여 정의된다고 할 것이다. Having described specific portions of the present invention in detail, those skilled in the art will appreciate that these specific descriptions are only for the preferred embodiment and that the scope of the present invention is not limited thereby. It will be obvious. Accordingly, the actual scope of the present invention will be defined by the appended claims and their equivalents.
Claims (8)
Cucumbers, yams, sperm, loofah, pine needles, seaweed, soybeans, and Japanese sap were mixed and extracted at a weight ratio of 10: 5: 5: 5: 10: 5: 5: 3: 2, respectively, and then the lactic acid bacteria were extracted into the extract. Lactobacillus paracasei ( Lactobacillus paracasei KW3110) as inoculated by natural fermentation extract, characterized in that it is prepared by fermentation.
The natural complex fermented extract of claim 1 as an active ingredient and includes any one or more of atopic dermatitis, allergic dermatitis, burns, athlete's foot, contact dermatitis, dandruff, alopecia areata, seborrheic dermatitis, psoriasis, scalp inflammation, and seborrheic hair loss Skin and scalp conditions, characterized by improving the skin and scalp conditions Improvement composition.
(2) 상기 혼합물을 분말화한 후 물로 추출하는 단계; 및
(3) 상기 추출액을 여과 후 젖산균으로서 락토바실러스 파라카세이(Lactobacillus paracasei KW3110)를 접종하여 발효시키는 단계;를 포함하는 것을 특징으로 하는 천연물 복합 발효 추출물 제조방법.
(1) mixing the cucumber grass, the yam, the squirrel, the scrubber, the pine needles, the seaweed, the soybean, the sancho, and the bamboo sap respectively in a weight ratio of 10: 5: 5: 5: 10: 5: 5: 3: 2;
(2) powdering the mixture and then extracting with water; And
(3) inoculating and fermenting the extract with Lactobacillus paracasei ( Lactobacillus paracasei KW3110) as lactic acid bacteria after filtration; natural product complex fermentation extract manufacturing method comprising a.
상기 발효는 30~50℃에서 24~72시간 동안 발효시키는 것을 특징으로 하는 천연물 복합 발효 추출물 제조방법.The method according to claim 6,
The fermentation is a natural product complex fermentation extract manufacturing method, characterized in that the fermentation for 30 to 50 hours at 30 ~ 50 ℃.
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