CN104825347B - A kind of medical bio whitening and spot-eliminating dressing and preparation method thereof - Google Patents
A kind of medical bio whitening and spot-eliminating dressing and preparation method thereof Download PDFInfo
- Publication number
- CN104825347B CN104825347B CN201510269860.XA CN201510269860A CN104825347B CN 104825347 B CN104825347 B CN 104825347B CN 201510269860 A CN201510269860 A CN 201510269860A CN 104825347 B CN104825347 B CN 104825347B
- Authority
- CN
- China
- Prior art keywords
- spot
- whitening
- extracting solution
- vitamin
- skin
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
- 230000002087 whitening effect Effects 0.000 title claims abstract description 70
- 238000002360 preparation method Methods 0.000 title claims abstract description 24
- GVJHHUAWPYXKBD-UHFFFAOYSA-N (±)-α-Tocopherol Chemical compound OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-UHFFFAOYSA-N 0.000 claims abstract description 72
- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 claims abstract description 68
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims abstract description 66
- 239000010495 camellia oil Substances 0.000 claims abstract description 38
- 229930003427 Vitamin E Natural products 0.000 claims abstract description 36
- WIGCFUFOHFEKBI-UHFFFAOYSA-N gamma-tocopherol Natural products CC(C)CCCC(C)CCCC(C)CCCC1CCC2C(C)C(O)C(C)C(C)C2O1 WIGCFUFOHFEKBI-UHFFFAOYSA-N 0.000 claims abstract description 36
- 235000019165 vitamin E Nutrition 0.000 claims abstract description 36
- 229940046009 vitamin E Drugs 0.000 claims abstract description 36
- 239000011709 vitamin E Substances 0.000 claims abstract description 36
- AXTGDCSMTYGJND-UHFFFAOYSA-N 1-dodecylazepan-2-one Chemical compound CCCCCCCCCCCCN1CCCCCC1=O AXTGDCSMTYGJND-UHFFFAOYSA-N 0.000 claims abstract description 35
- 239000001944 prunus armeniaca kernel oil Substances 0.000 claims abstract description 35
- ZZZCUOFIHGPKAK-UHFFFAOYSA-N D-erythro-ascorbic acid Natural products OCC1OC(=O)C(O)=C1O ZZZCUOFIHGPKAK-UHFFFAOYSA-N 0.000 claims abstract description 34
- 229930003268 Vitamin C Natural products 0.000 claims abstract description 34
- 235000019154 vitamin C Nutrition 0.000 claims abstract description 34
- 239000011718 vitamin C Substances 0.000 claims abstract description 34
- 235000011187 glycerol Nutrition 0.000 claims abstract description 33
- 235000013793 astaxanthin Nutrition 0.000 claims abstract description 30
- JEBFVOLFMLUKLF-IFPLVEIFSA-N Astaxanthin Natural products CC(=C/C=C/C(=C/C=C/C1=C(C)C(=O)C(O)CC1(C)C)/C)C=CC=C(/C)C=CC=C(/C)C=CC2=C(C)C(=O)C(O)CC2(C)C JEBFVOLFMLUKLF-IFPLVEIFSA-N 0.000 claims abstract description 25
- 229940022405 astaxanthin Drugs 0.000 claims abstract description 25
- MQZIGYBFDRPAKN-ZWAPEEGVSA-N astaxanthin Chemical compound C([C@H](O)C(=O)C=1C)C(C)(C)C=1/C=C/C(/C)=C/C=C/C(/C)=C/C=C/C=C(C)C=CC=C(C)C=CC1=C(C)C(=O)[C@@H](O)CC1(C)C MQZIGYBFDRPAKN-ZWAPEEGVSA-N 0.000 claims abstract description 25
- 239000001168 astaxanthin Substances 0.000 claims abstract description 25
- OYHQOLUKZRVURQ-NTGFUMLPSA-N (9Z,12Z)-9,10,12,13-tetratritiooctadeca-9,12-dienoic acid Chemical compound C(CCCCCCC\C(=C(/C\C(=C(/CCCCC)\[3H])\[3H])\[3H])\[3H])(=O)O OYHQOLUKZRVURQ-NTGFUMLPSA-N 0.000 claims abstract description 20
- 239000000203 mixture Substances 0.000 claims abstract description 9
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 88
- 235000019441 ethanol Nutrition 0.000 claims description 44
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 39
- QQILFGKZUJYXGS-UHFFFAOYSA-N Indigo dye Chemical compound C1=CC=C2C(=O)C(C3=C(C4=CC=CC=C4N3)O)=NC2=C1 QQILFGKZUJYXGS-UHFFFAOYSA-N 0.000 claims description 16
- 239000008213 purified water Substances 0.000 claims description 16
- 230000001954 sterilising effect Effects 0.000 claims description 9
- 238000005303 weighing Methods 0.000 claims description 9
- 238000002156 mixing Methods 0.000 claims description 8
- 239000002994 raw material Substances 0.000 claims description 8
- 239000000843 powder Substances 0.000 claims description 6
- 241000606266 Nardostachys Species 0.000 claims description 2
- 229960005150 glycerol Drugs 0.000 claims 1
- 230000000694 effects Effects 0.000 abstract description 32
- XUMBMVFBXHLACL-UHFFFAOYSA-N Melanin Chemical compound O=C1C(=O)C(C2=CNC3=C(C(C(=O)C4=C32)=O)C)=C2C4=CNC2=C1C XUMBMVFBXHLACL-UHFFFAOYSA-N 0.000 abstract description 16
- 208000003351 Melanosis Diseases 0.000 abstract description 12
- 206010008570 Chloasma Diseases 0.000 abstract description 7
- 206010025421 Macule Diseases 0.000 abstract description 5
- 230000003020 moisturizing effect Effects 0.000 abstract description 5
- 102000003425 Tyrosinase Human genes 0.000 abstract description 4
- 108060008724 Tyrosinase Proteins 0.000 abstract description 4
- 239000004615 ingredient Substances 0.000 abstract description 4
- 230000005808 skin problem Effects 0.000 abstract description 4
- 208000037259 Amyloid Plaque Diseases 0.000 abstract description 3
- 208000012641 Pigmentation disease Diseases 0.000 abstract description 3
- 230000001815 facial effect Effects 0.000 abstract description 3
- 230000019612 pigmentation Effects 0.000 abstract description 3
- 239000000126 substance Substances 0.000 abstract description 3
- 230000003213 activating effect Effects 0.000 abstract description 2
- 238000000354 decomposition reaction Methods 0.000 abstract description 2
- 238000010612 desalination reaction Methods 0.000 abstract description 2
- 201000010099 disease Diseases 0.000 abstract description 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract description 2
- 239000005556 hormone Substances 0.000 abstract description 2
- 229940088597 hormone Drugs 0.000 abstract description 2
- 150000002926 oxygen Chemical class 0.000 abstract description 2
- 230000001737 promoting effect Effects 0.000 abstract description 2
- 230000009467 reduction Effects 0.000 abstract description 2
- 230000002000 scavenging effect Effects 0.000 abstract description 2
- 210000003491 skin Anatomy 0.000 description 31
- 241000238557 Decapoda Species 0.000 description 16
- OYHQOLUKZRVURQ-HZJYTTRNSA-N Linoleic acid Chemical compound CCCCC\C=C/C\C=C/CCCCCCCC(O)=O OYHQOLUKZRVURQ-HZJYTTRNSA-N 0.000 description 13
- 235000020778 linoleic acid Nutrition 0.000 description 13
- OYHQOLUKZRVURQ-IXWMQOLASA-N linoleic acid Natural products CCCCC\C=C/C\C=C\CCCCCCCC(O)=O OYHQOLUKZRVURQ-IXWMQOLASA-N 0.000 description 13
- 239000003814 drug Substances 0.000 description 6
- 239000000463 material Substances 0.000 description 6
- 150000001514 astaxanthins Chemical class 0.000 description 5
- XEEYBQQBJWHFJM-UHFFFAOYSA-N Iron Chemical compound [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 description 4
- 239000002537 cosmetic Substances 0.000 description 4
- 238000001914 filtration Methods 0.000 description 4
- BJRNKVDFDLYUGJ-RMPHRYRLSA-N hydroquinone O-beta-D-glucopyranoside Chemical class O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1OC1=CC=C(O)C=C1 BJRNKVDFDLYUGJ-RMPHRYRLSA-N 0.000 description 4
- 238000007654 immersion Methods 0.000 description 4
- GFBCWCDNXDKFRH-UHFFFAOYSA-N 4-(oxan-2-yloxy)phenol Chemical compound C1=CC(O)=CC=C1OC1OCCCC1 GFBCWCDNXDKFRH-UHFFFAOYSA-N 0.000 description 3
- 208000027418 Wounds and injury Diseases 0.000 description 3
- 238000010521 absorption reaction Methods 0.000 description 3
- 239000002253 acid Substances 0.000 description 3
- 239000004480 active ingredient Substances 0.000 description 3
- 239000003963 antioxidant agent Substances 0.000 description 3
- 230000015572 biosynthetic process Effects 0.000 description 3
- 210000004027 cell Anatomy 0.000 description 3
- 239000003795 chemical substances by application Substances 0.000 description 3
- 230000006378 damage Effects 0.000 description 3
- 229940079593 drug Drugs 0.000 description 3
- 239000000284 extract Substances 0.000 description 3
- 150000002632 lipids Chemical class 0.000 description 3
- 230000037303 wrinkles Effects 0.000 description 3
- FPIPGXGPPPQFEQ-UHFFFAOYSA-N 13-cis retinol Natural products OCC=C(C)C=CC=C(C)C=CC1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-UHFFFAOYSA-N 0.000 description 2
- 108060006004 Ascorbate peroxidase Proteins 0.000 description 2
- 102000008186 Collagen Human genes 0.000 description 2
- 108010035532 Collagen Proteins 0.000 description 2
- 229920000832 Cutin Polymers 0.000 description 2
- 239000010282 Emodin Substances 0.000 description 2
- QIGBRXMKCJKVMJ-UHFFFAOYSA-N Hydroquinone Chemical compound OC1=CC=C(O)C=C1 QIGBRXMKCJKVMJ-UHFFFAOYSA-N 0.000 description 2
- OUYCCCASQSFEME-QMMMGPOBSA-N L-tyrosine Chemical compound OC(=O)[C@@H](N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-QMMMGPOBSA-N 0.000 description 2
- 206010042496 Sunburn Diseases 0.000 description 2
- 244000269722 Thea sinensis Species 0.000 description 2
- FPIPGXGPPPQFEQ-BOOMUCAASA-N Vitamin A Natural products OC/C=C(/C)\C=C\C=C(\C)/C=C/C1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-BOOMUCAASA-N 0.000 description 2
- 230000032683 aging Effects 0.000 description 2
- FPIPGXGPPPQFEQ-OVSJKPMPSA-N all-trans-retinol Chemical compound OC\C=C(/C)\C=C\C=C(/C)\C=C\C1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-OVSJKPMPSA-N 0.000 description 2
- 230000003712 anti-aging effect Effects 0.000 description 2
- 230000003110 anti-inflammatory effect Effects 0.000 description 2
- 230000003078 antioxidant effect Effects 0.000 description 2
- 235000006708 antioxidants Nutrition 0.000 description 2
- 229960000271 arbutin Drugs 0.000 description 2
- 230000003796 beauty Effects 0.000 description 2
- 229920001436 collagen Polymers 0.000 description 2
- 239000006071 cream Substances 0.000 description 2
- RHMXXJGYXNZAPX-UHFFFAOYSA-N emodin Chemical compound C1=C(O)C=C2C(=O)C3=CC(C)=CC(O)=C3C(=O)C2=C1O RHMXXJGYXNZAPX-UHFFFAOYSA-N 0.000 description 2
- 235000019197 fats Nutrition 0.000 description 2
- OVBPIULPVIDEAO-LBPRGKRZSA-N folic acid Chemical compound C=1N=C2NC(N)=NC(=O)C2=NC=1CNC1=CC=C(C(=O)N[C@@H](CCC(O)=O)C(O)=O)C=C1 OVBPIULPVIDEAO-LBPRGKRZSA-N 0.000 description 2
- 235000020688 green tea extract Nutrition 0.000 description 2
- 229940094952 green tea extract Drugs 0.000 description 2
- 230000006872 improvement Effects 0.000 description 2
- 208000014674 injury Diseases 0.000 description 2
- 229910052742 iron Inorganic materials 0.000 description 2
- 230000004060 metabolic process Effects 0.000 description 2
- 238000000034 method Methods 0.000 description 2
- 230000003647 oxidation Effects 0.000 description 2
- 238000007254 oxidation reaction Methods 0.000 description 2
- BJRNKVDFDLYUGJ-UHFFFAOYSA-N p-hydroxyphenyl beta-D-alloside Natural products OC1C(O)C(O)C(CO)OC1OC1=CC=C(O)C=C1 BJRNKVDFDLYUGJ-UHFFFAOYSA-N 0.000 description 2
- 239000000049 pigment Substances 0.000 description 2
- 150000008442 polyphenolic compounds Chemical class 0.000 description 2
- 235000013824 polyphenols Nutrition 0.000 description 2
- 102000004169 proteins and genes Human genes 0.000 description 2
- 108090000623 proteins and genes Proteins 0.000 description 2
- 239000011669 selenium Substances 0.000 description 2
- 239000002904 solvent Substances 0.000 description 2
- 235000013616 tea Nutrition 0.000 description 2
- OUYCCCASQSFEME-UHFFFAOYSA-N tyrosine Natural products OC(=O)C(N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-UHFFFAOYSA-N 0.000 description 2
- 235000015112 vegetable and seed oil Nutrition 0.000 description 2
- 229940088594 vitamin Drugs 0.000 description 2
- 229930003231 vitamin Natural products 0.000 description 2
- 235000013343 vitamin Nutrition 0.000 description 2
- 239000011782 vitamin Substances 0.000 description 2
- 235000019155 vitamin A Nutrition 0.000 description 2
- 239000011719 vitamin A Substances 0.000 description 2
- 229940045997 vitamin a Drugs 0.000 description 2
- YYGNTYWPHWGJRM-UHFFFAOYSA-N (6E,10E,14E,18E)-2,6,10,15,19,23-hexamethyltetracosa-2,6,10,14,18,22-hexaene Chemical compound CC(C)=CCCC(C)=CCCC(C)=CCCC=C(C)CCC=C(C)CCC=C(C)C YYGNTYWPHWGJRM-UHFFFAOYSA-N 0.000 description 1
- 208000002874 Acne Vulgaris Diseases 0.000 description 1
- 235000019489 Almond oil Nutrition 0.000 description 1
- 240000001548 Camellia japonica Species 0.000 description 1
- 244000147058 Derris elliptica Species 0.000 description 1
- LCGLNKUTAGEVQW-UHFFFAOYSA-N Dimethyl ether Chemical compound COC LCGLNKUTAGEVQW-UHFFFAOYSA-N 0.000 description 1
- 102000016942 Elastin Human genes 0.000 description 1
- 108010014258 Elastin Proteins 0.000 description 1
- 208000017701 Endocrine disease Diseases 0.000 description 1
- BIVBRWYINDPWKA-VLQRKCJKSA-L Glycyrrhizinate dipotassium Chemical compound [K+].[K+].O([C@@H]1[C@@H](O)[C@H](O)[C@H](O[C@@H]1O[C@H]1CC[C@]2(C)[C@H]3C(=O)C=C4[C@@H]5C[C@](C)(CC[C@@]5(CC[C@@]4(C)[C@]3(C)CC[C@H]2C1(C)C)C)C(O)=O)C([O-])=O)[C@@H]1O[C@H](C([O-])=O)[C@@H](O)[C@H](O)[C@H]1O BIVBRWYINDPWKA-VLQRKCJKSA-L 0.000 description 1
- 206010020649 Hyperkeratosis Diseases 0.000 description 1
- 206010020651 Hyperkinesia Diseases 0.000 description 1
- 208000000269 Hyperkinesis Diseases 0.000 description 1
- 206010061218 Inflammation Diseases 0.000 description 1
- 208000001126 Keratosis Diseases 0.000 description 1
- COLNVLDHVKWLRT-QMMMGPOBSA-N L-phenylalanine Chemical compound OC(=O)[C@@H](N)CC1=CC=CC=C1 COLNVLDHVKWLRT-QMMMGPOBSA-N 0.000 description 1
- 206010027146 Melanoderma Diseases 0.000 description 1
- 108010052285 Membrane Proteins Proteins 0.000 description 1
- 102000018697 Membrane Proteins Human genes 0.000 description 1
- 239000004909 Moisturizer Substances 0.000 description 1
- 208000000112 Myalgia Diseases 0.000 description 1
- SNIXRMIHFOIVBB-UHFFFAOYSA-N N-Hydroxyl-tryptamine Chemical compound C1=CC=C2C(CCNO)=CNC2=C1 SNIXRMIHFOIVBB-UHFFFAOYSA-N 0.000 description 1
- OVBPIULPVIDEAO-UHFFFAOYSA-N N-Pteroyl-L-glutaminsaeure Natural products C=1N=C2NC(N)=NC(=O)C2=NC=1CNC1=CC=C(C(=O)NC(CCC(O)=O)C(O)=O)C=C1 OVBPIULPVIDEAO-UHFFFAOYSA-N 0.000 description 1
- AQGDXJQRVOCUQX-UHFFFAOYSA-N N.[S] Chemical compound N.[S] AQGDXJQRVOCUQX-UHFFFAOYSA-N 0.000 description 1
- 244000018633 Prunus armeniaca Species 0.000 description 1
- 235000009827 Prunus armeniaca Nutrition 0.000 description 1
- QNVSXXGDAPORNA-UHFFFAOYSA-N Resveratrol Natural products OC1=CC=CC(C=CC=2C=C(O)C(O)=CC=2)=C1 QNVSXXGDAPORNA-UHFFFAOYSA-N 0.000 description 1
- BUGBHKTXTAQXES-UHFFFAOYSA-N Selenium Chemical compound [Se] BUGBHKTXTAQXES-UHFFFAOYSA-N 0.000 description 1
- 206010040829 Skin discolouration Diseases 0.000 description 1
- 206010040925 Skin striae Diseases 0.000 description 1
- BHEOSNUKNHRBNM-UHFFFAOYSA-N Tetramethylsqualene Natural products CC(=C)C(C)CCC(=C)C(C)CCC(C)=CCCC=C(C)CCC(C)C(=C)CCC(C)C(C)=C BHEOSNUKNHRBNM-UHFFFAOYSA-N 0.000 description 1
- 241000130764 Tinea Species 0.000 description 1
- 208000002474 Tinea Diseases 0.000 description 1
- LUKBXSAWLPMMSZ-OWOJBTEDSA-N Trans-resveratrol Chemical compound C1=CC(O)=CC=C1\C=C\C1=CC(O)=CC(O)=C1 LUKBXSAWLPMMSZ-OWOJBTEDSA-N 0.000 description 1
- 230000002159 abnormal effect Effects 0.000 description 1
- 238000009825 accumulation Methods 0.000 description 1
- 206010000496 acne Diseases 0.000 description 1
- 239000000654 additive Substances 0.000 description 1
- 230000000996 additive effect Effects 0.000 description 1
- 239000008168 almond oil Substances 0.000 description 1
- 230000036592 analgesia Effects 0.000 description 1
- 150000008425 anthrones Chemical class 0.000 description 1
- 230000000845 anti-microbial effect Effects 0.000 description 1
- 230000003064 anti-oxidating effect Effects 0.000 description 1
- 206010003246 arthritis Diseases 0.000 description 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical group [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 1
- 239000002199 base oil Substances 0.000 description 1
- 230000000740 bleeding effect Effects 0.000 description 1
- 210000004204 blood vessel Anatomy 0.000 description 1
- 150000001720 carbohydrates Chemical class 0.000 description 1
- BVKZGUZCCUSVTD-UHFFFAOYSA-N carbonic acid Chemical compound OC(O)=O BVKZGUZCCUSVTD-UHFFFAOYSA-N 0.000 description 1
- 230000008859 change Effects 0.000 description 1
- 230000001684 chronic effect Effects 0.000 description 1
- 239000003086 colorant Substances 0.000 description 1
- 235000018597 common camellia Nutrition 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 230000007812 deficiency Effects 0.000 description 1
- 238000005238 degreasing Methods 0.000 description 1
- 230000008021 deposition Effects 0.000 description 1
- 239000000645 desinfectant Substances 0.000 description 1
- 239000003599 detergent Substances 0.000 description 1
- 238000011161 development Methods 0.000 description 1
- 230000018109 developmental process Effects 0.000 description 1
- 238000009792 diffusion process Methods 0.000 description 1
- 229940101029 dipotassium glycyrrhizinate Drugs 0.000 description 1
- PRAKJMSDJKAYCZ-UHFFFAOYSA-N dodecahydrosqualene Natural products CC(C)CCCC(C)CCCC(C)CCCCC(C)CCCC(C)CCCC(C)C PRAKJMSDJKAYCZ-UHFFFAOYSA-N 0.000 description 1
- 239000002552 dosage form Substances 0.000 description 1
- 238000001035 drying Methods 0.000 description 1
- 235000013399 edible fruits Nutrition 0.000 description 1
- 229920002549 elastin Polymers 0.000 description 1
- 239000003995 emulsifying agent Substances 0.000 description 1
- 208000030172 endocrine system disease Diseases 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 230000002708 enhancing effect Effects 0.000 description 1
- 239000003344 environmental pollutant Substances 0.000 description 1
- 238000003912 environmental pollution Methods 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 235000013312 flour Nutrition 0.000 description 1
- 229960000304 folic acid Drugs 0.000 description 1
- 235000019152 folic acid Nutrition 0.000 description 1
- 239000011724 folic acid Substances 0.000 description 1
- 230000003779 hair growth Effects 0.000 description 1
- 230000035876 healing Effects 0.000 description 1
- 230000036541 health Effects 0.000 description 1
- 230000033444 hydroxylation Effects 0.000 description 1
- 238000005805 hydroxylation reaction Methods 0.000 description 1
- 239000003230 hygroscopic agent Substances 0.000 description 1
- 230000000774 hypoallergenic effect Effects 0.000 description 1
- 230000036737 immune function Effects 0.000 description 1
- 238000001727 in vivo Methods 0.000 description 1
- 230000004054 inflammatory process Effects 0.000 description 1
- 229910052500 inorganic mineral Inorganic materials 0.000 description 1
- 230000003993 interaction Effects 0.000 description 1
- 230000001788 irregular Effects 0.000 description 1
- 239000002085 irritant Substances 0.000 description 1
- 239000000314 lubricant Substances 0.000 description 1
- 230000001050 lubricating effect Effects 0.000 description 1
- 230000001404 mediated effect Effects 0.000 description 1
- 239000011707 mineral Substances 0.000 description 1
- 230000000116 mitigating effect Effects 0.000 description 1
- 230000001333 moisturizer Effects 0.000 description 1
- 210000004400 mucous membrane Anatomy 0.000 description 1
- 210000003205 muscle Anatomy 0.000 description 1
- 239000003921 oil Substances 0.000 description 1
- 235000019198 oils Nutrition 0.000 description 1
- 239000003883 ointment base Substances 0.000 description 1
- 239000004006 olive oil Substances 0.000 description 1
- 235000008390 olive oil Nutrition 0.000 description 1
- 230000003287 optical effect Effects 0.000 description 1
- 230000036542 oxidative stress Effects 0.000 description 1
- 229910052760 oxygen Inorganic materials 0.000 description 1
- 239000001301 oxygen Substances 0.000 description 1
- -1 oxygen radical Chemical class 0.000 description 1
- 239000008188 pellet Substances 0.000 description 1
- COLNVLDHVKWLRT-UHFFFAOYSA-N phenylalanine Natural products OC(=O)C(N)CC1=CC=CC=C1 COLNVLDHVKWLRT-UHFFFAOYSA-N 0.000 description 1
- 231100000719 pollutant Toxicity 0.000 description 1
- 230000035935 pregnancy Effects 0.000 description 1
- 230000005855 radiation Effects 0.000 description 1
- 150000003254 radicals Chemical class 0.000 description 1
- 238000011084 recovery Methods 0.000 description 1
- 230000008929 regeneration Effects 0.000 description 1
- 238000011069 regeneration method Methods 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 230000000284 resting effect Effects 0.000 description 1
- 235000021283 resveratrol Nutrition 0.000 description 1
- 229940016667 resveratrol Drugs 0.000 description 1
- 231100000241 scar Toxicity 0.000 description 1
- 230000028327 secretion Effects 0.000 description 1
- 229910052711 selenium Inorganic materials 0.000 description 1
- 230000009759 skin aging Effects 0.000 description 1
- 210000004927 skin cell Anatomy 0.000 description 1
- 230000037394 skin elasticity Effects 0.000 description 1
- 230000036559 skin health Effects 0.000 description 1
- 210000000952 spleen Anatomy 0.000 description 1
- 229940031439 squalene Drugs 0.000 description 1
- TUHBEKDERLKLEC-UHFFFAOYSA-N squalene Natural products CC(=CCCC(=CCCC(=CCCC=C(/C)CCC=C(/C)CC=C(C)C)C)C)C TUHBEKDERLKLEC-UHFFFAOYSA-N 0.000 description 1
- 230000000087 stabilizing effect Effects 0.000 description 1
- 230000035882 stress Effects 0.000 description 1
- 239000000516 sunscreening agent Substances 0.000 description 1
- 230000002195 synergetic effect Effects 0.000 description 1
- 238000012360 testing method Methods 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- 210000001519 tissue Anatomy 0.000 description 1
- 235000021081 unsaturated fats Nutrition 0.000 description 1
- 239000008158 vegetable oil Substances 0.000 description 1
- 239000004034 viscosity adjusting agent Substances 0.000 description 1
- 150000003722 vitamin derivatives Chemical class 0.000 description 1
- 239000002699 waste material Substances 0.000 description 1
- 230000010148 water-pollination Effects 0.000 description 1
- 238000009736 wetting Methods 0.000 description 1
Landscapes
- Cosmetics (AREA)
Abstract
The present invention relates to a kind of medical dressing,More particularly to a kind of medical bio whitening and spot-eliminating dressing and preparation method thereof,The present invention is with D Arbutins,Camellia oil,Linoleic acid,Apricot kernel oil,Main component of the astaxanthin as whitening spot-removing,And it is aided with azone,Glycerine,Vitamin C,The ingredients such as vitamin E,Pass through rational compatibility,The basal layer that medical bio whitening and spot-eliminating dressing obtained can not only effectively penetrate to the skin,And the activity of tyrosinase can be effectively inhibited,Efficient scavenging activated oxygen,Prevent the generation of melanin,The existing melanin of reduction decomposition simultaneously,Activating cell,The facial spot of desalination,Gradually chloasma is eliminated,Butterfly macules,The skin problem that the pigmentations such as senile plaque expelling trigger,It is repaired simultaneously since the chemical compositions such as hormone are damaged caused by skin,It is comprehensively quick so as to reach,The effect treated both principal and secondary aspect of disease,So that skin-whitening,Moisten moisturizing,Gloss is fine and smooth.Preparation method of the present invention is simple, easy to use, convenient for promoting.
Description
Technical field
The present invention relates to medical dressing technical fields, and in particular to a kind of medical bio whitening and spot-eliminating dressing and its preparation side
Method.
Background technology
Everybody has a love of beauty, and with the continuous improvement of people's living standard, people are also continuous to beautiful pursuit
It improves, for most of women, is intended to change the appearance of oneself and possesses the pale colour of skin.But come for women
It says, with advancing age, the metabolism of body slows down, and melanin can not be mediated normally, and deposit to form spot in cuticula
Point, by and form chloasma, blackspot and color spot；Life is nervous, and irregular and various environmental pollutions of working and resting are led to that itself is supported
Drag declines, and endocrine disorder makes interior free yl activate, and increases melanin abnormal secretion.And for some born skins
For partially black women, whitening is even more their unremitting pursuit.
For example, the Chinese invention patent of Application No. 201310552253.5 is disclosed a kind of skin-whitening speckle-removing cream, feature
It is, the active ingredient of following weight proportion is mainly contained in ointment bases：5 parts of β-ursin, 1 part of dipotassium glycyrrhizinate, azone
1 part.But the said goods whitening spot-removing effect is still undesirable, is also produced in the prior art without a kind of more efficiently whitening spot-removing
Product, in view of this, it is necessary to a kind of more efficiently whitening and freckle-removing product be provided, can effectively solve chloasma, butterfly macules and old
The skin problem that the pigmentations such as year spot trigger, and with notable whitening effect.
The content of the invention
In view of the above-mentioned deficiencies in the prior art, it is an object of the present invention to it is beautiful to provide a kind of good medical bio of whitening spot-removing effect
White Eradicates spot dressing.
To achieve these goals, the present invention adopts the following technical scheme that：A kind of medical bio whitening and spot-eliminating dressing, it is special
Sign is：The medical bio whitening and spot-eliminating dressing comprises the following raw materials by weight percent：
D- Arbutins 2-9%
Camellia oil 2-9%
Linoleic acid 0.5-3.5%
Azone 0.4-1.2%
Apricot kernel oil 7-15%
Glycerine 7-15%
Astaxanthin 1-5%
Vitamin C 1-4%
Vitamin E 0.1-2%
Ethyl alcohol 6-14%
Purify water surplus.
Preferably, the medical bio whitening and spot-eliminating dressing comprises the following raw materials by weight percent：
D- Arbutins 2-5%
Camellia oil 2-5%
Linoleic acid 0.5-2%
Azone 0.4-0.8%
Apricot kernel oil 7-10%
Glycerine 7-10%
Astaxanthin 1-3%
Vitamin C 1-2%
Vitamin E 0.1-1%
Ethyl alcohol 6-10%
Purify water surplus.
Another preferred, the medical bio whitening and spot-eliminating dressing comprises the following raw materials by weight percent：
D- Arbutins 5-9%
Camellia oil 5-9%
Linoleic acid 2-3.5%
Azone 0.8-1.2%
Apricot kernel oil 10-15%
Glycerine 10-15%
Astaxanthin 3-5%
Vitamin C 2-4%
Vitamin E 1-2%
Ethyl alcohol 10-14%
Purify water surplus.
It is more highly preferred to, the medical bio whitening and spot-eliminating dressing comprises the following raw materials by weight percent：
D- Arbutins 5%
Camellia oil 5%
Linoleic acid 2%
Azone 0.8%
Apricot kernel oil 10%
Glycerine 10%
Astaxanthin 3%
Vitamin C 2%
Vitamin E 1%
Ethyl alcohol 10%
Purify water surplus.
Another to be more highly preferred to, the medical bio whitening and spot-eliminating dressing comprises the following raw materials by weight percent：
D- Arbutins 4%
Camellia oil 5%
Linoleic acid 1.5%
Azone 0.9%
Apricot kernel oil 9%
Glycerine 11%
Astaxanthin 3%
Vitamin C 2%
Vitamin E 1%
Ethyl alcohol 10%
Purify water surplus.
The astaxanthin is excellent A astaxanthins.
The ethyl alcohol is the ethyl alcohol that mass fraction is 75%.
A kind of preparation method of medical bio whitening and spot-eliminating dressing, it includes following preparation process：
Step A, weigh：The D- Arbutins of weighing formula ratio, camellia oil, linoleic acid, azone, apricot kernel oil, glycerine, shrimp are blue or green
Element, vitamin C, vitamin E, ethyl alcohol, purified water；
Step B, prepare：By the load weighted D- Arbutins of step A, camellia oil, linoleic acid, azone, apricot kernel oil, glycerine, shrimp
Blue or green element, vitamin C, vitamin E, ethyl alcohol, purified water are put into container, are stirred until homogeneous, sterilizing, thus obtaining the product medical bio whitening Eradicates
Spot dressing.
On this basis, a kind of medical bio whitening and spot-eliminating dressing, the medical bio whitening and spot-eliminating dressing is by following
The raw material composition of weight percent：
D- Arbutins 2-9%
Camellia oil 2-9%
Linoleic acid 0.5-3.5%
Azone 0.4-1.2%
Apricot kernel oil 7-15%
Glycerine 7-15%
Astaxanthin 1-5%
Vitamin C 1-4%
Vitamin E 0.1-2%
Ethyl alcohol 6-14%
Rhizoma Atractylodis Macrocephalae extracting solution 2-6%
Polygoni cuspidati,radix extracting solution 1-3%
Indigo naturalis extracting solution 1-3%
Rhizoma nardostachyos extracting solution 1-3%
Purify water surplus.
A kind of preparation method of medical bio whitening and spot-eliminating dressing, it includes following preparation process：
Step A, weigh：The D- Arbutins of weighing formula ratio, camellia oil, linoleic acid, azone, apricot kernel oil, glycerine, shrimp are blue or green
Element, vitamin C, vitamin E, ethyl alcohol, Rhizoma Atractylodis Macrocephalae extracting solution, polygoni cuspidati,radix extracting solution, indigo naturalis extracting solution, rhizoma nardostachyos extracting solution, purified water；
Step B, prepare：By the load weighted D- Arbutins of step A, camellia oil, linoleic acid, azone, apricot kernel oil, glycerine, shrimp
Blue or green element, vitamin C, vitamin E, ethyl alcohol, Rhizoma Atractylodis Macrocephalae extracting solution, polygoni cuspidati,radix extracting solution, indigo naturalis extracting solution, rhizoma nardostachyos extracting solution, purifying
Water is put into container, is stirred until homogeneous, sterilizing, thus obtaining the product medical bio whitening and spot-eliminating dressing.
D- Arbutins, that is, D-Arbutin of the present invention, is one of derivative of Arbutin, can be in skin histology effectively
Ground inhibits the effect of Tyrosine ferment, and 10 times of its effect even hydroquinone, be 350 times of general Arbutin.Dynamic
In the skin test of object, this D-Arbutin can quickly and effectively allow whitening skin, and after stopping using, effect is still
It can maintain the time of nearly 8 weeks.It is local using may be significantly in 12 weeks of D-Arbutin in the clinical research of human body
Skin lightening effect, for day optical activity exposure spot and obscure colour of skin situation, even more there is good improvement.
The camellia oil of the present invention is distinctive unsaturated fat acid lipid, is obtained from tea oil tree seed.The heat of camellia seed oil
Stability is good, it may have to the defencive function of the basic nature of skin, and contains the natural anti-reflecting oxides such as carrotene and tea polyphenols
Matter, has a specific function of skin care, and it is smaller that camellia oil through experiment measures its surface tension, is approached with olive oil, diffusion system
Number is big, is easy to extension on the skin and absorbs, and is not required to additionally add emulsifier, therefore camellia oil can be as a kind of shield of good properties
Skin feed of base oil is applied.Camellia oil energy uvioresistant prevents sunburn and reduces wrinkle, very effective to chloasma sunburn
Fruit;Camellia oil contains abundant natural VE, tea polyphenols, squalene, unrighted acid etc., these all possess beauty
Anti-aging function, unrighted acid can inhibit fat, prevent three high functions, long-time service make people skin smooth,
It is moist.
The linoleic acid of the present invention is crude vegetal, can promote D- Arbutin synergistic functions, additionally it is possible to effectively be inhibited
The activity of tyrosinase reduces melanin and is formed, there is VE effects, can also moisturizing, anti-irritant, hypo-allergenic.
The azone of the present invention is used as bleeding agent, for all kinds of creams and hair care product in cosmetics；Azone is to oleophylic, hydrophily
Drug and active ingredient have it is apparent it is transdermal help oozing effect, make keratoderma and lipid interaction, reduce working substance
The phase inversion temperature of matter lipid into cutin lamellar spacing, adds mobility, makes drug or active additive in cuticula
Diffusional resistance is reduced, therefore is played the role of very strong rush and oozed.
The apricot kernel oil of the present invention is a kind of skin care and moisturizing effect rich in minerals, protein and various vitamins
Splendid vegetable oil, suitable for various skin quality.It can effectively mitigate pruitus phenomenon, eliminate redness, dryness and inflammation.Apricot
Benevolence oil can make skin recover smooth soft and fine, if long-time service can effectively eliminate striae of pregnancy.Since apricot kernel oil is extremely mild,
Therefore connecting baby can use, further for the myalgia that hyperkinesia causes, if can be strengthened with Sweet Almond Oil massage thin
Born of the same parents accumulate with oxygen function, dispelling fatigue with carbonic acid, have analgesia and abirritant effect.In addition, apricot kernel oil can anti-canthus wrinkle
Line.
Glycerine has lubricating action, and the dosage form of formation has toughness and protectiveness, makes with soapy feeling, as moisturizer
Longer wetting time can be kept, sliding capability is good, can extend agent in mucous membrane local efficacy, there is good lubricant effect；
Hygroscopic agent, viscosity modifier and solvent can be used as.
Astaxanthin is one of natural most strong in the world, the oxygen radical in effective scavenger-cell, and enhancing is thin
Born of the same parents' power of regeneration, maintains organism balance and reduces the accumulation of senile cell, cell and DNA health is protected from inside to outside, so as to protect
Skin health is protected, promotes hair growth, anti-aging alleviates sports fatigue, invigorates.The molecule knot that astaxanthin has its unique
Structure, the absorption peak of substance is exactly 470nm or so, with UVA wavelength（380-420nm）Close therefore micro astaxanthin is just
Substantial amounts of UVA can be absorbed, like the natural sun-screening agents of most perfect uniqueness on the earth, such as natural anti-sunshade bedding whole body,
Can efficiently ultraviolet radiation preventing, be quenched UV-induced free radical, reducing ultraviolet light prevents the injury of skin.Except this
In addition, it also can rapidly restore the skin destroyed by ultraviolet burn.Astaxanthin can then be obviously reduced ROS and NMP couples
The destruction of skin corium collagen, elastin ensures the eubolism of skin.
The ascorbic effect of the present invention and function：Vitamin C is formed for antibody and collagen, tissue repairing（Including some
Redox）, the metabolism of phenylalanine, tyrosine, folic acid, the utilization of iron, carbohydrate, fat, the conjunction of protein
Into maintaining immune function, hydroxylation and hydroxytryptamine, keep the complete of blood vessel, promote the institute such as nonheme iron absorption required, tie up simultaneously
Raw element C has been also equipped with anti-oxidant, Green Tea Extract, inhibits the formation of tyrosinase, so as to reach whitening, the effect of light spot.In people
In vivo, vitamin C is high-efficiency antioxidant agent, for mitigating ascorbate peroxidase enzyme（ascorbate peroxidase）Base
The oxidation stress at bottom（oxidative stress）.There are many more vitamin C participation is also required in important biosynthetic process
Effect.
The effect of the vitamin E of the present invention and function：Skin is protected, makes skin flexible.Vitamin E energy stabilizing cell membrane
Protein active structure, promote muscle normal development and keep skin elasticity, skin and body is made to maintain vigour；Vitamin
E, which enters Skin Cell, more can directly help infringement of the skin to Green Tea Extract, ultraviolet light and pollutant, reduce scar and pigment
Deposition;Accelerate the healing of wound.It slows down aging, effectively reduces the generation of wrinkle, the appearance to retain youth.Vitamin E is a kind of
Liposoluble vitamin is one of most important antioxidant, can prevent fatty compound, vitamin A, selenium（Se）, two kinds of sulphur ammonia
The sour and ascorbic oxidation of base improves the effect of vitamin A；Prevent skin because some are chronic or when recessive injury loses
Elasticity is gone until aging, prevents skin aging.
Ethyl alcohol can promote skin to absorb in cosmetics, and active ingredient is contributed to penetrate skin, that is to say, that its
Real ethyl alcohol plays the effect for promoting cosmetic effect.In addition, ethyl alcohol contributes to oil-control, promote coming off for waste and old cutin, have
Good convergence effect, ethyl alcohol is heretofore known best disinfectant, fabulous detergent and degreasing in cosmetic field
Agent.
On this basis, the present invention can also add a certain amount of Chinese medicine extract, the Chinese medicine extract that the present invention uses with
Above-mentioned raw materials cooperate, and whitening spot-removing effect is even better, and Chinese medicine extract used has the following effects that：
It is light that Rhizoma Atractylodis Macrocephalae has heat-clearing and damp-drying drug, desinsection, treatment skin tinea, de-black fine flour, and firm tooth black hair, promotion melanin to be metabolized
The effect of spot.Rhizoma Atractylodis Macrocephalae extracting solution is through 1 by 80 mesh Rhizoma Atractylodis Macrocephalae powder and 100 degrees Celsius of hot water:It is used after when 5 ratios mixing immersion 12 is small
80 mesh sieve net filtrations and obtain.
Resveratrol and rheum emodin in polygoni cuspidati,radix have extensive anti-oxidation characteristics, other ingredient pellet anthrones, rheum emodin
Methyl ether and Rhein all have anti-inflammatory, arthritis of dispelling and antimicrobial acivity.Polygoni cuspidati,radix extracting solution is by 80 mesh polygoni cuspidati,radix powder
End and 100 degrees Celsius of hot water are through 1:It is obtained after when 5 ratios mixing immersion 12 is small with 80 mesh sieve net filtrations.
Indigo naturalis has whitening, anti-inflammatory, the effect of going acne print.Indigo naturalis extracting solution is by 80 mesh indigo naturalis powder and 100 degrees Celsius
Hot water is through 1:It is obtained after when 5 ratios mixing immersion 12 is small with 80 mesh sieve net filtrations.
There is rhizoma nardostachyos pungent fragrant row to dissipate, it is kind open spleen it is strongly fragrant and except face it is black the effect of.Rhizoma nardostachyos extracting solution be by 80 mesh Nardostachys Roots and
100 degrees Celsius of hot water are through 1:It is obtained after when 5 ratios mixing immersion 12 is small with 80 mesh sieve net filtrations.
Purified water not only as solvent but also can be skin moisturizing.
Compared with prior art, advantageous effect is the present invention：
（1）The present invention using D- Arbutins, camellia oil, linoleic acid, apricot kernel oil, astaxanthin as whitening spot-removing it is main into
Point, and it is aided with the ingredients such as azone, glycerine, vitamin C, vitamin E, and by rational compatibility, medical bio whitening Eradicates obtained
The basal layer that spot dressing can not only effectively penetrate to the skin, and the activity of tyrosinase can be effectively inhibited, efficiently
Scavenging activated oxygen prevents the generation of melanin, while the existing melanin of reduction decomposition, and activating cell desalinates facial spot,
Gradually the skin problem that the pigmentations such as chloasma, butterfly macules, senile plaque expelling trigger is eliminated, while is repaired due to chemistry such as hormones
Ingredient is damaged caused by skin, so as to achieve the effect that comprehensively it is quick, treat both principal and secondary aspect of disease so that skin-whitening moistens moisturizing, light
It is damp fine and smooth.The present invention preparation method it is simple, easy to use, convenient for promote the advantages that.
（2）The biocompatibility of the medical bio whitening and spot-eliminating dressing of the present invention meets GB/T 16886.11-2011 will
It asks.
Specific embodiment
With reference to embodiment, the present invention is further illustrated.
Embodiment 1.
A kind of medical bio whitening and spot-eliminating dressing, the medical bio whitening and spot-eliminating dressing by following weight percent original
Material composition：
D- Arbutins 2%
Camellia oil 2%
Linoleic acid 0.5%
Azone 0.4%
Apricot kernel oil 7%
Glycerine 7%
Astaxanthin 1%
Vitamin C 1%
Vitamin E 0.1%
Ethyl alcohol 6%
Purify water surplus.
The astaxanthin is excellent A astaxanthins.
The ethyl alcohol is the ethyl alcohol that mass fraction is 75%.
A kind of preparation method of medical bio whitening and spot-eliminating dressing, it includes following preparation process：
Step A, weigh：The D- Arbutins of weighing formula ratio, camellia oil, linoleic acid, azone, apricot kernel oil, glycerine, shrimp are blue or green
Element, vitamin C, vitamin E, ethyl alcohol, purified water；
Step B, prepare：By the load weighted D- Arbutins of step A, camellia oil, linoleic acid, azone, apricot kernel oil, glycerine, shrimp
Blue or green element, vitamin C, vitamin E, ethyl alcohol, purified water are put into container, are stirred until homogeneous, sterilizing, thus obtaining the product medical bio whitening Eradicates
Spot dressing.
Embodiment 2.
A kind of medical bio whitening and spot-eliminating dressing, the medical bio whitening and spot-eliminating dressing by following weight percent original
Material composition：
D- Arbutins 5%
Camellia oil 5%
Linoleic acid 2%
Azone 0.8%
Apricot kernel oil 10%
Glycerine 10%
Astaxanthin 3%
Vitamin C 2%
Vitamin E 1%
Ethyl alcohol 10%
Purify water surplus.
The astaxanthin is excellent A astaxanthins.
The ethyl alcohol is the ethyl alcohol that mass fraction is 75%.
A kind of preparation method of medical bio whitening and spot-eliminating dressing, it includes following preparation process：
Step A, weigh：The D- Arbutins of weighing formula ratio, camellia oil, linoleic acid, azone, apricot kernel oil, glycerine, shrimp are blue or green
Element, vitamin C, vitamin E, ethyl alcohol, purified water；
Step B, prepare：By the load weighted D- Arbutins of step A, camellia oil, linoleic acid, azone, apricot kernel oil, glycerine, shrimp
Blue or green element, vitamin C, vitamin E, ethyl alcohol, purified water are put into container, are stirred until homogeneous, sterilizing, thus obtaining the product medical bio whitening Eradicates
Spot dressing.
Embodiment 3.
A kind of medical bio whitening and spot-eliminating dressing, the medical bio whitening and spot-eliminating dressing by following weight percent original
Material composition：
D- Arbutins 4%
Camellia oil 5%
Linoleic acid 1.5%
Azone 0.9%
Apricot kernel oil 9%
Glycerine 11%
Astaxanthin 3%
Vitamin C 2%
Vitamin E 1%
Ethyl alcohol 10%
Purify water surplus.
The astaxanthin is excellent A astaxanthins.
The ethyl alcohol is the ethyl alcohol that mass fraction is 75%.
A kind of preparation method of medical bio whitening and spot-eliminating dressing, it includes following preparation process：
Step A, weigh：The D- Arbutins of weighing formula ratio, camellia oil, linoleic acid, azone, apricot kernel oil, glycerine, shrimp are blue or green
Element, vitamin C, vitamin E, ethyl alcohol, purified water；
Step B, prepare：By the load weighted D- Arbutins of step A, camellia oil, linoleic acid, azone, apricot kernel oil, glycerine, shrimp
Blue or green element, vitamin C, vitamin E, ethyl alcohol, purified water are put into container, are stirred until homogeneous, sterilizing, thus obtaining the product medical bio whitening Eradicates
Spot dressing.
Embodiment 4.
A kind of medical bio whitening and spot-eliminating dressing, the medical bio whitening and spot-eliminating dressing by following weight percent original
Material composition：
D- Arbutins 9%
Camellia oil 9%
Linoleic acid 3.5%
Azone 1.2%
Apricot kernel oil 15%
Glycerine 15%
Astaxanthin 5%
Vitamin C 4%
Vitamin E 2%
Ethyl alcohol 14%
Purify water surplus.
The astaxanthin is excellent A astaxanthins.
The ethyl alcohol is the ethyl alcohol that mass fraction is 75%.
A kind of preparation method of medical bio whitening and spot-eliminating dressing it include following preparation process：
Step A, weigh：The D- Arbutins of weighing formula ratio, camellia oil, linoleic acid, azone, apricot kernel oil, glycerine, shrimp are blue or green
Element, vitamin C, vitamin E, ethyl alcohol, purified water；
Step B, prepare：By the load weighted D- Arbutins of step A, camellia oil, linoleic acid, azone, apricot kernel oil, glycerine, shrimp
Blue or green element, vitamin C, vitamin E, ethyl alcohol, purified water are put into container, are stirred until homogeneous, sterilizing, thus obtaining the product medical bio whitening Eradicates
Spot dressing.
Embodiment 5.
A kind of medical bio whitening and spot-eliminating dressing, the medical bio whitening and spot-eliminating dressing by following weight percent original
Material composition：
D- Arbutins 3%
Camellia oil 3%
Linoleic acid 1%
Azone 1%
Apricot kernel oil 8%
Glycerine 8%
Astaxanthin 2%
Vitamin C 2%
Vitamin E 1%
Ethyl alcohol 7%
Rhizoma Atractylodis Macrocephalae extracting solution 3%
Polygoni cuspidati,radix extracting solution 2%
Indigo naturalis extracting solution 1%
Rhizoma nardostachyos extracting solution 1%
Purify water surplus.
A kind of preparation method of medical bio whitening and spot-eliminating dressing, it includes following preparation process：
Step A, weigh：The D- Arbutins of weighing formula ratio, camellia oil, linoleic acid, azone, apricot kernel oil, glycerine, shrimp are blue or green
Element, vitamin C, vitamin E, ethyl alcohol, Rhizoma Atractylodis Macrocephalae extracting solution, polygoni cuspidati,radix extracting solution, indigo naturalis extracting solution, rhizoma nardostachyos extracting solution, purified water；
Step B, prepare：By the load weighted D- Arbutins of step A, camellia oil, linoleic acid, azone, apricot kernel oil, glycerine, shrimp
Blue or green element, vitamin C, vitamin E, ethyl alcohol, Rhizoma Atractylodis Macrocephalae extracting solution, polygoni cuspidati,radix extracting solution, indigo naturalis extracting solution, rhizoma nardostachyos extracting solution, purifying
Water is put into container, is stirred until homogeneous, sterilizing, thus obtaining the product medical bio whitening and spot-eliminating dressing.
Embodiment 6.
A kind of medical bio whitening and spot-eliminating dressing, the medical bio whitening and spot-eliminating dressing by following weight percent original
Material composition：
D- Arbutins 8%
Camellia oil 8%
Linoleic acid 3%
Azone 1%
Apricot kernel oil 14%
Glycerine 14%
Astaxanthin 4%
Vitamin C 3%
Vitamin E 1%
Ethyl alcohol 12%
Rhizoma Atractylodis Macrocephalae extracting solution 5%
Polygoni cuspidati,radix extracting solution 2%
Indigo naturalis extracting solution 2%
Rhizoma nardostachyos extracting solution 2%
Purify water surplus.
A kind of preparation method of medical bio whitening and spot-eliminating dressing, it includes following preparation process：
Step A, weigh：The D- Arbutins of weighing formula ratio, camellia oil, linoleic acid, azone, apricot kernel oil, glycerine, shrimp are blue or green
Element, vitamin C, vitamin E, ethyl alcohol, Rhizoma Atractylodis Macrocephalae extracting solution, polygoni cuspidati,radix extracting solution, indigo naturalis extracting solution, rhizoma nardostachyos extracting solution, purified water；
Step B, prepare：By the load weighted D- Arbutins of step A, camellia oil, linoleic acid, azone, apricot kernel oil, glycerine, shrimp
Blue or green element, vitamin C, vitamin E, ethyl alcohol, Rhizoma Atractylodis Macrocephalae extracting solution, polygoni cuspidati,radix extracting solution, indigo naturalis extracting solution, rhizoma nardostachyos extracting solution, purifying
Water is put into container, is stirred until homogeneous, sterilizing, thus obtaining the product medical bio whitening and spot-eliminating dressing.
Using the product prepared by embodiment 1 to 6,180 30-55 Sui Mies is selected to use, their face has not
With color spots problem and the skin such as the chloasma of degree, freckle, butterfly macules and senile plaque expelling it is partially black the problem of.By this 180 Mies with
Machine is divided into 6 groups, wherein, first group of 30 Mies use the medical bio whitening and spot-eliminating dressing of embodiment 1,30 of second group
Ms uses the medical bio whitening and spot-eliminating dressing of embodiment 2, and the 3rd group of 30 Mies use the medical bio of embodiment 3
Whitening and spot-eliminating dressing, the 4th group of 30 Mies use the medical bio whitening and spot-eliminating dressing of embodiment 4, the 5th group of 30 female
Scholar uses the medical bio whitening and spot-eliminating dressing of embodiment 5, and the 6th group of 30 Mies are beautiful using the medical bio of embodiment 6
White Eradicates spot dressing.In addition 30 30-55 Sui Mies is selected to use the whitening and freckle-removing product of the prior art, in contrast organize seven,
This 30 Mies of control group seven can the unrestricted choice prior art other freckle removing and whitening products.
The application method of the present invention：It is warmed after daily morning and evening washed with medical bio whitening and spot-eliminating dressing 3-5g in the centre of the palm
Afterwards, it is applied on the face, is then softly massaged into absorption from inside to outside：
Control group is used according to the description of product that oneself is chosen.
Following table is using the effect after each embodiment and the whitening and freckle-removing product of control group after 30 days.
Wherein, criterion of therapeutical effect is：Recovery from illness：Face's spot disappears substantially；It is effective：Face's spot regression more than 50%；Have
Effect：Face's spot regression more than 10% or spot colors turn light；It is invalid：It is unchanged before and after treatment.
Clinical case：
Mrs Cai, 30 years old, skin formed large stretch of color spot after being subject to ultraviolet ray burn, and after this product 20 days, color spot is light
Change, be continuing with, after 45 days, color spot is desalinated significantly, and after 60 days, not seeing substantially has color spot, and skin smooth is fine and smooth.
Mrs Wang, 45 years old, face was with the concurrent chloasma of freckle, and many nti-freckle product of the black Huang of skin of face, effect is not
Ideal, using 4 course for the treatment of freckles, chloasma disappearance blee bleaches, and skin is glossy.
Mrs Li, 27 years old, face was with pregnant occasion spot during pregnancy, and using many nti-freckle product after production, point effect is undesirable, makes
It is thin out with pregnant occasion spot after this product 15 days, it is disappeared using pregnant occasion spot after 45 days, skin gloss is pale.
Ms Zhang, 44 years old, partially black on the face and have a large amount of color spots, after this product one month, facial skin is pale, and color spot is big
Big desalination.
It can be seen that the present invention has apparent whitening spot-removing effect, the pigments such as chloasma, butterfly macules can be effectively solved
The skin problem that calmness triggers, easy to use, whitening effect is notable.
Finally it should be noted that the above embodiments are merely illustrative of the technical solutions of the present invention rather than the present invention is protected
The limitation of scope is protected, although being explained in detail with reference to preferred embodiment to the present invention, those of ordinary skill in the art should
Work as understanding, technical scheme can be modified or replaced equivalently, without departing from the reality of technical solution of the present invention
Matter and scope.
Claims (2)
1. a kind of medical bio whitening and spot-eliminating dressing, it is characterised in that：The medical bio whitening and spot-eliminating dressing is by following weight
The raw material composition of percentage：
The Rhizoma Atractylodis Macrocephalae extracting solution is through 1 by 80 mesh Rhizoma Atractylodis Macrocephalae powder and 100 degrees Celsius of hot water:5 ratios mixing impregnate after filter and
；The polygoni cuspidati,radix extracting solution is through 1 by 80 mesh polygoni cuspidati,radix powder and 100 degrees Celsius of hot water:The mixing of 5 ratios is filtered after impregnating
And it obtains；The indigo naturalis extracting solution is through 1 by 80 mesh indigo naturalis powder and 100 degrees Celsius of hot water:5 ratios mixing impregnate after filter and
；The rhizoma nardostachyos extracting solution is through 1 by 80 mesh Nardostachys Roots and 100 degrees Celsius of hot water:5 ratios mixing impregnate after filter and
.
2. a kind of preparation method of medical bio whitening and spot-eliminating dressing described in claim 1, it is characterised in that：It includes following
Preparation process：
Step A, weigh：The D- Arbutins of weighing formula ratio, camellia oil, linoleic acid, azone, apricot kernel oil, glycerine, astaxanthin, dimension
Raw element C, vitamin E, ethyl alcohol, Rhizoma Atractylodis Macrocephalae extracting solution, polygoni cuspidati,radix extracting solution, indigo naturalis extracting solution, rhizoma nardostachyos extracting solution, purified water；
Step B, prepare：By the load weighted D- Arbutins of step A, camellia oil, linoleic acid, azone, apricot kernel oil, glycerine, astaxanthin,
Vitamin C, vitamin E, ethyl alcohol, Rhizoma Atractylodis Macrocephalae extracting solution, polygoni cuspidati,radix extracting solution, indigo naturalis extracting solution, rhizoma nardostachyos extracting solution, purified water are put into
It in container, is stirred until homogeneous, sterilizing, thus obtaining the product medical bio whitening and spot-eliminating dressing.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510269860.XA CN104825347B (en) | 2015-05-25 | 2015-05-25 | A kind of medical bio whitening and spot-eliminating dressing and preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510269860.XA CN104825347B (en) | 2015-05-25 | 2015-05-25 | A kind of medical bio whitening and spot-eliminating dressing and preparation method thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN104825347A CN104825347A (en) | 2015-08-12 |
| CN104825347B true CN104825347B (en) | 2018-06-01 |
Family
ID=53803820
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201510269860.XA Active CN104825347B (en) | 2015-05-25 | 2015-05-25 | A kind of medical bio whitening and spot-eliminating dressing and preparation method thereof |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN104825347B (en) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106955253A (en) * | 2017-02-24 | 2017-07-18 | 覃淑兰 | A kind of preparation method of face mud |
| CN108567601A (en) * | 2017-03-13 | 2018-09-25 | 荆楚理工学院 | A kind of astaxanthin and the compound content in freckle cream of Tea Saponin |
| CN108815010A (en) * | 2018-09-26 | 2018-11-16 | 嫦娥创新（武汉）生物科技有限公司 | The composition and its cosmetics of a kind of whitening spot-removing and application |
| CN110559243B (en) * | 2019-09-26 | 2022-06-28 | 上海清轩生物科技有限公司 | Repairing and whitening composition containing camellia extract and microcapsule prepared from repairing and whitening composition |
| CN112121223B (en) * | 2020-10-16 | 2022-05-20 | 河南民兴生物科技股份有限公司 | Sericin medical dressing and production method thereof |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1408338A (en) * | 2001-09-28 | 2003-04-09 | 上海知菲化妆品有限公司 | Liposome beauty cosmetic and its producing method |
| CN102525837B (en) * | 2011-11-08 | 2013-09-11 | 海南光宇生物科技有限公司 | Astaxanthin-containing bacterial cellulose membrane product |
| CN102517174B (en) * | 2011-11-27 | 2013-08-28 | 郴州邦尔泰苏仙油脂有限公司 | Camellia facial soap |
| CN102415959A (en) * | 2011-12-04 | 2012-04-18 | 汕头市中乾网络科技有限公司 | Whitening vanishing cream |
| CN102860978A (en) * | 2012-10-12 | 2013-01-09 | 苏州谷力生物科技有限公司 | Skin whitening cream |
| CN103340792B (en) * | 2013-07-05 | 2015-04-29 | 上海珍馨化工科技有限公司 | Spikenard oil toner |
| CN104546609B (en) * | 2015-01-09 | 2017-09-19 | 湖南新金浩茶油股份有限公司 | A kind of crease-resistant nursing oil of oil tea |
-
2015
- 2015-05-25 CN CN201510269860.XA patent/CN104825347B/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| CN104825347A (en) | 2015-08-12 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN106580797B (en) | A kind of whitening and spot eliminating cream and preparation method thereof | |
| KR101373636B1 (en) | Composition for improving condition of skin and scalp containing fermented extracts of herb mixture | |
| CN104825347B (en) | A kind of medical bio whitening and spot-eliminating dressing and preparation method thereof | |
| CN102078283B (en) | Traditional Chinese medicinal nutritional emulsifiable paste for whitening skin and removing speckles | |
| CN106074206B (en) | A kind of skin care host agent, preparation method and applications | |
| KR101860307B1 (en) | Cosmetic composition for moisturizing skin containing water-soluble silicon | |
| KR101196523B1 (en) | Composition for promoting hair growth comprising fermented oriental medicine extract | |
| KR102307509B1 (en) | Composition for hairloss and scalp care | |
| CN108653013A (en) | A kind of plant moisturizing water profit after-sun frost and preparation method thereof | |
| KR101744889B1 (en) | Composition for Anti-oxidation, Whitening and Wrinkles protection | |
| CN109310724A (en) | It is a kind of for skin and/or the composition of hair nursing and/or treatment | |
| KR101168796B1 (en) | Skin care cosmetic composition | |
| KR101547758B1 (en) | Composition for preventing hair loss and promoting hair growth | |
| CN108567862A (en) | Mite killing is releived compound borneol essential oil and preparation method thereof | |
| WO2015010372A1 (en) | Cream used for treatment of acne hyperpigmentation spot and for whitening | |
| CN107441340B (en) | Hand and foot chap cream for relieving swelling, pain and itching and nourishing skin and preparation method thereof | |
| CN101822624B (en) | Composition containing thioctic acid and extract of root of red-rooted salvia and application thereof in cosmetics | |
| CN104352400A (en) | Freckle removing cream | |
| EA025061B1 (en) | Therapeutic and cosmetic emulsion cream | |
| CN109620795A (en) | A kind of whitening and spot eliminating cream and preparation method thereof of releiving of the ferment powder containing whitening | |
| KR100886879B1 (en) | Composition for applying human | |
| Trak et al. | Skin Care Secrets from Herbal World | |
| RU2384322C2 (en) | Day gel cream for dry and normal skin | |
| KR101687293B1 (en) | Cosmetic composition for improving wrinkle and atopic dermatitis and cosmetic comprising the complex composition | |
| CN108403588A (en) | Natural animal-plant skin cream |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| EXSB | Decision made by sipo to initiate substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| CB02 | Change of applicant information |
Address after: 537300, Guigang County, the Guangxi Zhuang Autonomous Region, Linjiang Industrial Park, third feeder roads and access to the South Road junction, Guangxi grand Biological Technology Co., Ltd. Applicant after: GUANGXI DAQING BIOTECHNOLOGY Co.,Ltd. Address before: 537300, Guigang County, the Guangxi Zhuang Autonomous Region, Linjiang Industrial Park, third feeder roads and access to the South Road junction, Guangxi grand Biological Technology Co., Ltd. Applicant before: GUANGXI DAQING BIOLOGICAL SCIENCE & TECHNOLOGY CO.,LTD. |
|
| COR | Change of bibliographic data | ||
| GR01 | Patent grant | ||
| GR01 | Patent grant | ||
| CP03 | Change of name, title or address |
Address after: 537000 Pingnan County Industrial Park, Guigang City, the Guangxi Zhuang Autonomous Region Patentee after: GUANGXI DAQING BIOLOGICAL SCIENCE & TECHNOLOGY CO.,LTD. Address before: 537300 the Guangxi Zhuang Autonomous Region, Guigang City, Pingnan County Linjiang Industrial Park third branch road and the junction of the South Road, Guangxi Daqing Biotechnology Co., Ltd. Patentee before: GUANGXI DAQING BIOTECHNOLOGY Co.,Ltd. |
|
| CP03 | Change of name, title or address | ||
| EE01 | Entry into force of recordation of patent licensing contract |
Application publication date: 20150812 Assignee: GUANGXI XINYE BIOLOGICAL TECHNOLOGY Co.,Ltd. Assignor: GUANGXI DAQING BIOLOGICAL SCIENCE & TECHNOLOGY CO.,LTD. Contract record no.: X2023980043753 Denomination of invention: A medical biological whitening and freckle removing dressing and its preparation method Granted publication date: 20180601 License type: Common License Record date: 20231019 |
|
| EE01 | Entry into force of recordation of patent licensing contract | ||
| PE01 | Entry into force of the registration of the contract for pledge of patent right |
Denomination of invention: A medical biological whitening and freckle removing dressing and its preparation method Effective date of registration: 20231030 Granted publication date: 20180601 Pledgee: Bank of China Limited Pingnan Branch Pledgor: GUANGXI DAQING BIOLOGICAL SCIENCE & TECHNOLOGY CO.,LTD. Registration number: Y2023980063362 |
|
| PE01 | Entry into force of the registration of the contract for pledge of patent right |