CN102525837B - Astaxanthin-containing bacterial cellulose membrane product - Google Patents
Astaxanthin-containing bacterial cellulose membrane product Download PDFInfo
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- CN102525837B CN102525837B CN 201110350049 CN201110350049A CN102525837B CN 102525837 B CN102525837 B CN 102525837B CN 201110350049 CN201110350049 CN 201110350049 CN 201110350049 A CN201110350049 A CN 201110350049A CN 102525837 B CN102525837 B CN 102525837B
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Abstract
The invention relates to an astaxanthin-containing bacterial cellulose membrane product. The unique astaxanthin-containing bacterial cellulose membrane product is obtained by uniformly dispersing astaxanthin into a fine mesh-shaped structure of bacterial cellulose. The disadvantage that the astaxanthin cannot be stored for a long time under general preservation conditions is overcome; and meanwhile, a good beauty and skin care product with anti-aging and whitening functions is also provided for consumers. The astaxanthin in the bacterial cellulose membrane product has stable properties, the structure of the astaxanthin cannot be damaged, and the astaxanthin can be slowly and durably released to the applied skin when the product is used, and achieve good effects of resisting senility, oxidization and wrinkles, whitening and protecting sunshine. Meanwhile, the membrane product also has good water supplement and moisturizing effects due to high water retention performance of the bacterial cellulose.
Description
Technical field
The present invention relates to a kind of beauty and skin care product.
Background technology
Astaxanthin is from river crayfish shell, a kind of pink group carotene of finding in Concha Ostreae and the salmon, and chemical name is 3,3 '-dihydroxy-4,4 '-diketo-β, β '-carotene, pigment Aj067-69, CAS No:472-61-7, molecular formula C40H52O4, molecular weight 596.86.Can be blue or green, blue in vivo with protein bound.Antioxidation, defying age, antitumor, the effect of prevention cardiovascular and cerebrovascular disease are arranged.Be that the mankind find the strongest antioxidant of nature up to now, its antioxidant activity is considerably beyond existing antioxidant.
The source of astaxanthin mainly is divided into chemosynthesis and natural extract.Commonly used is the natural extract method, normally extracts astaxanthin from processing of aquatic products refuse, cultivation algae and yeast, and output is all lower.Astaxanthin can make from carotene with chemical method.Natural astaxanthin is mainly from Haematocoocus Pluvialls.
Astaxanthin is because its antioxidant activity can effectively protect skin to avoid ultraviolet (UVA, infringement UVB).It also has the ability of eliminating free radical, can prevent that Skin Cell is subjected to the damage of free radical, reduces the generation of wrinkle and freckle.So it becomes a kind of good novel cosmetic raw material with defying age, whitening function now.
But astaxanthin specific molecule structure has determined also to be easy to be subjected to the effect of light, heat, oxide etc. and has destroyed.The character instability, easy loss of activity in the cosmetics goods.
Summary of the invention
At above-mentioned defective, the invention provides a kind of Bacterial cellulose membrane product that contains astaxanthin.
Bacterial cellulose is by synthetic cellulosic general designation such as the certain micro-organisms in acetic acid Pseudomonas (Acetobacter), Agrobacterium (Agrobacterium), rhizobium (Rhizobium) and the Sarcina (Sarcina) etc., it can form unique hyperfine network structure by the biosynthesis effect of microorganism.Had a lot of distinguished characteristics, as the elastic modelling quantity of Bacterial cellulose is more than Plant fiber's the several times to ten times, and the tensile strength height; Bacterial fibers have very strong moisture holding capacity.The WRV value of the Bacterial cellulose of undried is up to more than 1000%, and the moisture holding capacity after the lyophilization still surpasses 600%.Suitable through again swelling ability and the cotton linter of 100 ℃ of dried Bacterial cellulose in water; Bacterial fibers have higher biocompatibility, adaptability and good biodegradability.The present invention namely utilizes the above-mentioned characteristic of Bacterial cellulose, by astaxanthin is dispersed in the meticulous network structure of Bacterial cellulose uniformly, has obtained the Bacterial cellulose membrane product of unique astaxanthin-containing.Solve astaxanthin is difficult for long preservation under general preservation condition defective well, offered consumer a kind of extraordinary beauty and skin care product with defying age, whitening function simultaneously again.Astaxanthin character in the described Bacterial cellulose membrane product is highly stable, and structure can not destroyed, and can slowly and muchly astaxanthin be discharged in use on the deposited skin of institute, play good defying age, antioxidation, crease-resistant, whiten and sun-proof effect.Owing to the high water retention property of Bacterial cellulose, membrane product of the present invention also has extraordinary replenishing water and preserving moisture effect simultaneously.
Employed astaxanthin among the present invention can be natural astaxanthin or synthesizing astaxanthin.Be preferably the astaxanthin of natural extract, effect is best.
In order to play better beautifying skin-protection function, Bacterial cellulose membrane product of the present invention can also contain other an amount of skin care ingredients, and these skin care ingredients include but not limited to have the coenzyme Q10 of crease-resistant effect and/or the arbutin of whitening function.
The preparation method that contains the Bacterial cellulose membrane product of astaxanthin of the present invention is that the astaxanthin Emulsion with mass concentration 1% is added in the Bacterial cellulose fermentation medium, and making the content astaxanthin in the culture medium is 20-500ppm; This fermentation medium static fermentation of recycling is produced Bacterial cellulose, obtains the Bacterial cellulose membrane product of astaxanthin-containing.The Bacterial cellulose membrane product that obtains thus can be enclosed in astaxanthin in its meticulous network structure, is able to the stable of retention properties; In use, can slowly and muchly discharge again.Adding other skin protection materials if desired, also is it to be added into carry out biosynthesis in the fermentation medium, and as also being added with coenzyme Q10 and/or arbutin in the culture medium, wherein the addition of coenzyme Q10 is that to make the coenzyme Q10 content in the culture medium be 10-100ppm; The addition of arbutin is that to make the arbutin content in the culture medium be 5-50ppm.This kind method is applicable to the skin protection material that molecular weight is moderate, and it is water insoluble generally speaking, or unstable chemcial property.To be added into fermentation medium after its emulsifying, in the biosynthetic process of Bacterial cellulose, it is surrounded wherein, but can not influence its chemical property; And these skin protection materials can not influence the synthetic of Bacterial cellulose yet.
Coenzyme Q10 wherein, Chinese another name: coenzyme; Ubiquinone; Ubidecarenone; Co-ferment Q10; CAS RN.:303-98-0; Molecular formula: C59H90O4; Meeting light easily decomposes; Can be widely used in industries such as food, cosmetics, dietary supplement.Be a kind of antioxidant and nonspecific immunity strengthening agent.It is water insoluble, the Emulsion that is prepared into debita spissitudo is added in the fermentation medium, in the biosynthetic process of Bacterial cellulose it is wrapped in network structure, in use, obtain slowly and muchly discharging with astaxanthin, play very effective defying age, crease-resistant effect.
Arbutin wherein, chemical name: right-hydroxy benzenes-β-the D-pyranglucoside, another name: Arbutin, Arbutin, ericalin, arbutin, Arbutosie, Ursin, Uresol, Arbutus extract, molecular formula: C12H16O7, molecular weight: 272.25, CAS number: 497-76-7.The arbutin extraction is from the leaf of Folium Vaccinii vitis-idaeae, it can infiltrate skin rapidly, when not influencing cell proliferation concentration, can suppress the activity of the tryrosinase in the skin effectively, block melanic formation, by self and the direct combination of cheese ammonia enzyme, accelerate melanic decomposition and drainage, thereby reduce skin pigment deposition, dispelling stain and freckle, and melanocyte do not produced side effect such as toxic, zest, sensitization, also have the effect of sterilization, antiinflammatory simultaneously.It is a kind of raw material of whitening safely and effectively.Arbutin can be water-soluble, but the character instability is decomposed easily.The present invention is used arbutin and astaxanthin; the strong anti-oxidation activity of astaxanthin is good protective agent for arbutin; both ideally merge in the network structure of Bacterial cellulose for it, play effectiveness simultaneously, play preserve moisture, whiten, sun-proof, the anti-ageing effect of waiting for a long time.Use the membrane product of arbutin to be preferably in the use at night.
In the above-mentioned preparation method, the fermented bacterium of Bacterial cellulose is preferably acetobacter xylinum or gluconate pyracetobacillus.Contain carbon source and nitrogenous source for the capacity of strain growth in the fermentation medium, carbon source is preferably glucose, fructose, sucrose and/or Sucus Cocois.
Bacterial cellulose membrane product of the present invention is preferred for preparing the facial film goods of human body face.During use it smoothly is attached at face, holds time more than 30 minutes, life-time service, can play extraordinary defying age, antioxidation, crease-resistant, whiten and sun-proof effect.Also can be cut into different shape, be used for being attached at each position of human body, play corresponding effect, as a kind of high-end cosmetics and skincare product.
The specific embodiment
Below in conjunction with embodiment, the specific embodiment of the present invention is described in further detail.Following examples are used for explanation the present invention, but are not used for limiting the scope of the invention.
Embodiment 1:
A kind of anti-ageing face mask product, it is to be cut into corresponding size by the bacteria cellulose film that contains astaxanthin according to the human body face size.
The preparation method of the above-mentioned bacteria cellulose film that contains astaxanthin is as follows:
Natural left-handed astaxanthin Emulsion (emulsifying of Haematocoocus Pluvialls extract) ASTA-W1(operative norm Q/YSD03-2009 with mass concentration 1%) (available from Jingzhou City's natural astaxanthin company limited) is added in the Bacterial cellulose fermentation medium, and making the content astaxanthin in the culture medium is 200ppm; Also contain carbon source and the nitrogenous source that can supply gluconate pyracetobacillus fully to grow in the fermentation medium, utilize this fermentation medium inoculation gluconate pyracetobacillus activated seed liquid, static fermentation at normal temperatures, can collect bacterial cellulose wet-coating on the culture medium upper strata in about 8-14 days, this wet film namely is the bacteria cellulose film of astaxanthin-containing.
Embodiment 2:
A kind of defying age, anti-wrinkle face mask product, it is to be cut into corresponding size by the bacteria cellulose film that contains astaxanthin and coenzyme Q10 according to the human body face size.
The preparation method of the above-mentioned bacteria cellulose film that contains astaxanthin and coenzyme Q10 is as follows:
Coenzyme Q10 powder (melt rise bio tech ltd available from Xi'an) is prepared into the Emulsion of mass concentration 1% with an amount of emulsifying agent, natural left-handed astaxanthin Emulsion (emulsifying of Haematocoocus Pluvialls extract) ASTA-W1(operative norm Q/YSD03-2009 with mass concentration 1%) (available from Jingzhou City's natural astaxanthin company limited) is added in the Bacterial cellulose fermentation medium together, making the content astaxanthin in the culture medium is 100ppm, and coenzyme Q10 content is 50ppm; Also contain carbon source and the nitrogenous source that can supply gluconate pyracetobacillus fully to grow in the fermentation medium, utilize this fermentation medium inoculation gluconate pyracetobacillus activated seed liquid, static fermentation at normal temperatures, can collect bacterial cellulose wet-coating on the culture medium upper strata in about 8-14 days, this wet film namely is the bacteria cellulose film of astaxanthin-containing and coenzyme Q10.
Embodiment 3:
A kind ofly whiten, use mask product antidotal night, it is to be cut into corresponding size by the bacteria cellulose film that contains astaxanthin and arbutin according to the human body face size.
The preparation method of the above-mentioned bacteria cellulose film that contains astaxanthin and arbutin is as follows:
Arbutin powder (available from Guangzhou alizarin chemical industry company limited in morning) is dissolved in the following warm water of 50 degree, make the solution of mass concentration 2%, natural left-handed astaxanthin Emulsion (emulsifying of Haematocoocus Pluvialls extract) ASTA-W1(operative norm Q/YSD03-2009 with mass concentration 1%) (available from Jingzhou City's natural astaxanthin company limited) is added in the Bacterial cellulose fermentation medium together, making the content astaxanthin in the culture medium is 50ppm, and arbutin content is 50ppm; Also contain carbon source and the nitrogenous source that can supply gluconate pyracetobacillus fully to grow in the fermentation medium, utilize this fermentation medium inoculation gluconate pyracetobacillus activated seed liquid, static fermentation at normal temperatures, can collect bacterial cellulose wet-coating on the culture medium upper strata in about 8-14 days, this wet film namely is the bacteria cellulose film of astaxanthin-containing and arbutin.
Embodiment 4:
A kind of defying age, crease-resistant body film product, it is to be cut into corresponding size by the bacteria cellulose film that contains astaxanthin according to the human body size, is attached at the single piece type body film of arms and legs portion and is used for being attached at northern single piece type body film product etc. as being used for.
The preparation method of the above-mentioned bacteria cellulose film that contains astaxanthin is as follows:
The natural left-handed astaxanthin Emulsion of mass concentration 1% (emulsifying of Haematocoocus Pluvialls extract) ASTA-W1(operative norm Q/YSD03-2009) (available from Jingzhou City's natural astaxanthin company limited) is added in the Bacterial cellulose fermentation medium, and making the content astaxanthin in the culture medium is 500ppm; Also contain carbon source and the nitrogenous source that can supply gluconate pyracetobacillus fully to grow in the fermentation medium, utilize this fermentation medium inoculation gluconate pyracetobacillus activated seed liquid, static fermentation at normal temperatures, can collect bacterial cellulose wet-coating on the culture medium upper strata in about 8-14 days, this wet film namely is the bacteria cellulose film of astaxanthin-containing.
Embodiment 5:
A kind ofly whiten, defying age, crease-resistant body film product, it is to be cut into corresponding size by the bacteria cellulose film that contains astaxanthin, coenzyme Q10 and arbutin according to the human body size, is attached at the single piece type body film of arms and legs portion and is used for being attached at northern single piece type body film product etc. as being used for.
The preparation method of above-mentioned bacteria cellulose film is as follows:
Coenzyme Q10 powder (melt rise bio tech ltd available from Xi'an) is prepared into the Emulsion of mass concentration 1% with an amount of emulsifying agent, arbutin powder (available from Guangzhou alizarin chemical industry company limited in morning) is dissolved in the following warm water of 50 degree, make the solution of mass concentration 2%, natural left-handed astaxanthin Emulsion (emulsifying of Haematocoocus Pluvialls extract) ASTA-W1(operative norm Q/YSD03-2009 with mass concentration 1%) (available from Jingzhou City's natural astaxanthin company limited) is added in the Bacterial cellulose fermentation medium, making the content astaxanthin in the culture medium is 20ppm, coenzyme Q10 content is 100ppm, and arbutin content is 10ppm; Also contain carbon source and the nitrogenous source that can supply gluconate pyracetobacillus fully to grow in the fermentation medium, utilize this fermentation medium inoculation gluconate pyracetobacillus activated seed liquid, static fermentation at normal temperatures, can collect bacterial cellulose wet-coating on the culture medium upper strata in about 8-14 days, this wet film namely is the bacteria cellulose film of astaxanthin-containing, coenzyme Q10 and arbutin.
The product of above-described embodiment 1-5 is offered three groups of aspiration experimenters use, every group of 12 people, another is organized 12 people and uses the Bacterial cellulose facial film or the body film that do not add astaxanthin to organize in contrast, uses every night 1 time, uses for 2 week, and all the other maintenances are normal.Result of the test finds that three groups of experimenters' skin is Paint Gloss flexible with matched group before comparing and using, and also facial wrinkles or body skin fold alleviate the experimenter of the product of use embodiment 2, embodiment 4 and embodiment 5 to some extent to a certain extent; Skin with matched group before the experimenter of use embodiment 3 and the product of embodiment 5 also compares and uses is more pale.
The above only is preferred implementation of the present invention; should be pointed out that for those skilled in the art, under the prerequisite that does not break away from the technology of the present invention principle; can also make some improvements and modifications, these improvements and modifications also should be considered as protection scope of the present invention.
Claims (2)
1. preparation method that contains the Bacterial cellulose membrane product of astaxanthin, it is characterized in that: astaxanthin Emulsion, coenzyme Q10 and the arbutin of mass concentration 1% are added in the Bacterial cellulose fermentation medium, and making the content astaxanthin in the culture medium is that 20-500ppm, coenzyme Q10 content are that 10-100ppm, arbutin content are 5-50ppm; This fermentation medium static fermentation of recycling is produced Bacterial cellulose, obtains the Bacterial cellulose membrane product of astaxanthin-containing.
2. according to the described preparation method of claim 1, it is characterized in that: described fermented bacterium is acetobacter xylinum or gluconate pyracetobacillus.
3. according to the described preparation method of claim 1, it is characterized in that: contain carbon source and nitrogenous source for the capacity of strain growth in the described fermentation medium, carbon source is glucose, fructose, sucrose and/or Sucus Cocois.
4. the Bacterial cellulose membrane product that contains astaxanthin that makes with the described preparation method of claim 1.
5. use the facial film goods that are used for human body face of the described Bacterial cellulose membrane product preparation of claim 4.
6. use the membrane product that is used for each position of human body of the described Bacterial cellulose membrane product preparation of claim 4.
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| CN103385896B (en) * | 2013-07-23 | 2015-03-25 | 钟春燕 | Preparation method of bacterial cellulose composite flavonoid compound |
| CN103340819B (en) * | 2013-07-23 | 2014-11-19 | 海南光宇生物科技有限公司 | Preparation method of bacterial cellulose facial mask with anti-radiation effect |
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| CN104922050A (en) * | 2015-07-06 | 2015-09-23 | 哈尔滨瑞康源生物科技有限公司 | Biological fermentation primary liquid mask and preparation method and storing method thereof |
| CN106214501A (en) * | 2016-09-18 | 2016-12-14 | 东南大学 | A kind of astaxanthin lipid nanometer capsule and preparation method thereof |
| CN108743436A (en) * | 2018-06-21 | 2018-11-06 | 云南民族大学 | A kind of preparation method containing oil ben and astaxanthin suncream |
| CN108703919B (en) * | 2018-08-25 | 2021-04-27 | 素妆生物科技(上海)有限公司 | Preparation method of biological cellulose facial mask capable of keeping water for long time |
| CN109674749B (en) * | 2019-01-07 | 2023-06-20 | 东北林业大学 | High-coenzyme Q10 content oral nanometer suspension and preparation process thereof |
| CN111484902B (en) * | 2019-01-28 | 2021-09-28 | 海南光宇生物科技有限公司 | Preparation method of concentrated enzyme-containing laundry beads |
| CN111484901B (en) * | 2019-01-28 | 2021-09-28 | 海南光宇生物科技有限公司 | Enzyme-containing laundry detergent and preparation method thereof |
| CN109966189B (en) * | 2019-04-26 | 2021-12-10 | 北京科技大学 | Antioxidant moisturizing microorganism living cell preparation and skin care product containing same |
| CN111686045A (en) * | 2020-06-02 | 2020-09-22 | 北京致成生物医学科技有限公司 | Skin-tendering facial mask made of plant-derived bacterial cellulose and preparation method of facial mask |
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| CN1872022A (en) * | 2006-03-29 | 2006-12-06 | 钟春燕 | Gel face pack prepared from bacteroidal cellulose |
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