CN106214501A - A kind of astaxanthin lipid nanometer capsule and preparation method thereof - Google Patents
A kind of astaxanthin lipid nanometer capsule and preparation method thereof Download PDFInfo
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- CN106214501A CN106214501A CN201610828701.3A CN201610828701A CN106214501A CN 106214501 A CN106214501 A CN 106214501A CN 201610828701 A CN201610828701 A CN 201610828701A CN 106214501 A CN106214501 A CN 106214501A
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- Prior art keywords
- astaxanthin
- lipid nanometer
- phospholipid
- nanometer capsule
- mixture
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/55—Phosphorus compounds
- A61K8/553—Phospholipids, e.g. lecithin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
- A61K8/11—Encapsulated compositions
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
- A61K8/345—Alcohols containing more than one hydroxy group
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/35—Ketones, e.g. benzophenone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/08—Anti-ageing preparations
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/56—Compounds, absorbed onto or entrapped into a solid carrier, e.g. encapsulated perfumes, inclusion compounds, sustained release forms
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- Epidemiology (AREA)
- Emergency Medicine (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Gerontology & Geriatric Medicine (AREA)
- Dermatology (AREA)
- Cosmetics (AREA)
- Medicinal Preparation (AREA)
Abstract
Present invention relates particularly to a kind of astaxanthin oil lipid nanometer capsule and preparation method thereof.The method is to be 0.1%～20% astaxanthin oil, 1%～10% phospholipid, 2%～20% dipropylene glycol, 20%～80% glycerol, 0.1%～20% mix homogeneously successively under the conditions of 50 DEG C～80 DEG C such as deionized water by percentage by weight, then processed by high pressure homogenize, i.e. can get particle diameter less than 250nm astaxanthin lipid nanometer capsule.This lipid nanometer capsule has steady quality, preparation is simple, water dispersible is good, bioavailability is high, the feature such as reproducible, can be widely used in cosmetic field.
Description
Technical field
The present invention relates to cosmetic technical field, particularly relate to a kind of lipid nanometer with astaxanthin oil as active component
Capsule and preparation method thereof.
Background technology
Astaxanthin, is the keto-acid carotenoid of a kind of non-vitamin a source, in cerise.It is widely present in biosphere, special
That in the feather of shrimp, Eriocheir sinensis, fish, frond, yeast and birds, content is higher, be carotenoid main in marine organisms body it
One.
Astaxanthin is one of the strongest Natural antioxidant, it is possible to effectively remove interior free yl, maintains organism balance,
Slowing down skin aging, protects skin health.In recent years, numerous studies prove that astaxanthin has stronger non-oxidizability, are delaying
Old and feeble aspect has positive effect.For Scavenging ability, astaxanthin is 6000 times of vitamin C efficacy, is dimension
1000 times of raw element E, are 100 times of beta-carotene effect etc., thus astaxanthin receive much concern at cosmetic field.In addition shrimp
Blue or green element also has certain health-care effect, has important value medical health care, is improving immunity, prophylaxis of tumours, cardiovascular
The aspects such as development that occur of the chronic disease such as disease, diabetes have positive facilitation.
Astaxanthin is a kind of liposoluble active thing, water solublity extreme difference, it is difficult to be applied directly to cosmetics play antioxidation,
Scavenging ability；And condition responsive to external world, be oxidized easily variable color in atmosphere, have a strong impact on products application and
Outward appearance.
Use nano-encapsulated technology can improve astaxanthin dissolubility in water and stability, and can be improved it joining
Compatibility in side.In the present invention, astaxanthin oil is prepared as lipid nanometer capsule, thus reduces the fishy smell of astaxanthin, and
Be conducive to astaxanthin to penetrate into deep skin and give full play to antioxidation.
Summary of the invention
Technical problem: it is an object of the invention to provide a kind of astaxanthin lipid nanometer capsule and preparation method thereof, thus increase
Add stability and water dispersible and the compatibility etc. of astaxanthin.
Another object of the present invention is to provide the application in anti-aging cosmetics of the astaxanthin lipid nanometer capsule.
Technical scheme: the preparation method of a kind of astaxanthin lipid nanometer capsule of the present invention, it is characterised in that: include following group
Point, percentage by weight be 0.1%～20% astaxanthin oil, 1%～10% phospholipid, 2%～20% dipropylene glycol, 20%～
80% glycerol, surplus are deionized water.
Phospholipid used by astaxanthin lipid nanometer capsule of the present invention is soybean lecithin, Ovum Gallus domesticus Flavus lecithin and hydrogenated phospholipid
In the mixture of one or more than one.
Phospholipid used by astaxanthin lipid nanometer capsule of the present invention is preferably the soybean lecithin of PC content >=50.
Astaxanthin lipid nanometer capsule preparation method of the present invention sequentially includes the following steps:
Step (1): make phosphorus under 40 DEG C～80 DEG C of temperature and stirring condition by formula proportion phospholipid and dipropylene glycol
Fat fully dissolves and obtains mixture I.
Step (2): add in said mixture I by astaxanthin oil by formula proportion, in 40 DEG C～80 DEG C of temperature and stirring
Under the conditions of be mixed into uniform solution and obtain mixtures II.
Step (3): by after the deionized water of formula proportion and glycerol mix homogeneously and be added in said mixture II, 40
DEG C～80 DEG C of temperature and stirring condition under be mixed into uniform solution and obtain mixtures III.
Step (4): being processed by said mixture III high pressure homogenize, high pressure homogenize pressure is 400～1000bar, circulation time
Number is 1～8 time, obtains astaxanthin lipid nanometer capsule after cooling.
Beneficial effect: compared with prior art, astaxanthin lipid nanometer capsule has the advantage that the present invention
(1) constant product quality, it is possible to decrease astaxanthin fishy smell, has resistance to cold and heat feature.
(2) water solublity improves so that the preparation of the cosmetics of astaxanthin-containing is simple, convenient.
(3) containing a large amount of glycerol in formula, improve the moistening effect of preparation.
(4) slow release astaxanthin, thus reach long-time cosmetic result.
(5) phospholipid is used to be primary emulsion due to this lipid nanometer capsule, similar to skin lipid structure, it is easy to shrimp is blue or green
Element penetrates into inside skin.
Accompanying drawing explanation
Fig. 1 is process step schematic diagram of the present invention.
Detailed description of the invention
Below the technical scheme in the embodiment of the present invention is carried out complete, detailed description, it is clear that described embodiment is
Section Example of the present invention, does not represent whole embodiment, and based on the embodiment in the present invention, this area other staff are not doing
Go out equivalency transform done under creative work premise, broadly fall into scope.Embodiment one:
Thering is provided the preparation method of a kind of astaxanthin lipid nanometer capsule, concrete steps include: by 6g phospholipid (PC60) and 12g mono-
Contracting dipropylene glycol 300r/min under the conditions of 80 DEG C stirs into homogeneous solution, then adds 5g astaxanthin oil in mixed liquor,
Stirring 5min, is eventually adding the mixed solution of 72g glycerol and 5g deionized water, and stirring 5min becomes homogeneous mixed solution.By above-mentioned
Mixing uniform solution high pressure homogenize processes, and pressure is 800bar, and cycle-index is 4 times, i.e. can get astaxanthin lipid nanometer capsule,
It is 91.63nm that this dispersion liquid records its particle diameter by photon correlation spectroscopy (PCS).
Embodiment two:
Thering is provided the preparation method of a kind of astaxanthin lipid nanometer capsule, concrete steps include: by 4g phospholipid (PC60) and 8g mono-
Contracting dipropylene glycol 300r/min under the conditions of 80 DEG C stirs into homogeneous solution, then adds 5g astaxanthin oil in mixed liquor,
Stirring 5min, is eventually adding the mixed solution of 78g glycerol and 5g deionized water, and stirring 5min becomes homogeneous mixed solution.By above-mentioned
Mixing uniform solution high pressure homogenize processes, and pressure is 800bar, and cycle-index is 4 times, i.e. can get astaxanthin lipid nanometer capsule,
It is 108.7nm that this dispersion liquid records its particle diameter by photon correlation spectroscopy (PCS).
Embodiment three:
Thering is provided the preparation method of a kind of astaxanthin lipid nanometer capsule, concrete steps include: by 5g phospholipid (PC60) and 10g mono-
Contracting dipropylene glycol 300r/min under the conditions of 80 DEG C stirs into homogeneous solution, then adds 3g astaxanthin in mixed liquor, stirs
Mixing 5min, be eventually adding the mixed solution of 73g glycerol and 9g deionized water, stirring 5min becomes homogeneous mixed solution.By above-mentioned mixed
Closing uniform solution high pressure homogenize to process, pressure is 700bar, and cycle-index is 4 times, i.e. can get translucent Vitamin E acetate
Lipid nanometer capsule, it is 111.1nm that this dispersion liquid records its particle diameter by photon correlation spectroscopy (PCS).
Embodiment four:
Thering is provided the preparation method of a kind of astaxanthin lipid nanometer capsule, concrete steps include: by 5g phospholipid (PC60) and 10g mono-
Contracting dipropylene glycol 300r/min under the conditions of 80 DEG C stirs into homogeneous solution, then adds 4g astaxanthin oil in mixed liquor,
Stirring 5min, is eventually adding the mixed solution of 71g glycerol and 10g deionized water, and stirring 5min becomes homogeneous mixed solution.By above-mentioned
Mixing uniform solution high pressure homogenize processes, and pressure is 600bar, and cycle-index is 4 times, i.e. can get translucent vitamin E acetic acid
Ester lipid nanometer capsule, it is 140.1nm that this dispersion liquid records its particle diameter by photon correlation spectroscopy (PCS).
Claims (5)
1. an astaxanthin lipid nanometer capsule, it is characterised in that: this nanocapsule includes following components, and percentage by weight is 0.1%
～20% astaxanthin oil, 1%～10% phospholipid, 2%～20% dipropylene glycol, 20%～80% glycerol, surplus for go from
Sub-water.
2. require described astaxanthin lipid nanometer capsule according to right 1, it is characterised in that: described phospholipid is soybean lecithin, egg yolk
The mixture of the one or more than one in lecithin and hydrogenated phospholipid.
3. require described astaxanthin lipid nanometer capsule according to right 1, it is characterised in that: described phospholipid is preferably PC content >=50
Soybean lecithin.
4. the preparation method of astaxanthin lipid nanometer capsule as described in right 1 requires, it is characterised in that the method presses following step
Suddenly carry out:
Step 1: make phospholipid abundant under 40 DEG C～80 DEG C of temperature and stirring condition by formula proportion phospholipid and dipropylene glycol
Dissolving obtains mixture I；
Step 2: add in said mixture I by astaxanthin oil by formula proportion, under 40 DEG C～80 DEG C of temperature and stirring condition
It is mixed into uniform solution and obtains mixtures II；
Step 3: be added in said mixture II, at 40 DEG C～80 DEG C after the deionized water of formula proportion and glycerol mix homogeneously
It is mixed into uniform solution at temperature and stirring condition and obtains mixtures III；
Step 4: being processed by said mixture III high pressure homogenize, high pressure homogenize pressure is 400～1000bar, and cycle-index is 1
～8 times, obtain astaxanthin lipid nanometer capsule after cooling.
5. the purposes of an astaxanthin lipid nanometer capsule as claimed in claim 1, it is characterised in that: described astaxanthin lipid is received
Rice capsule is applied to anti-aging cosmetics.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610828701.3A CN106214501A (en) | 2016-09-18 | 2016-09-18 | A kind of astaxanthin lipid nanometer capsule and preparation method thereof |
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| Application Number | Priority Date | Filing Date | Title |
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| CN201610828701.3A CN106214501A (en) | 2016-09-18 | 2016-09-18 | A kind of astaxanthin lipid nanometer capsule and preparation method thereof |
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| CN106214501A true CN106214501A (en) | 2016-12-14 |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111388340A (en) * | 2020-04-13 | 2020-07-10 | 上海新高姿化妆品有限公司 | Stable astaxanthin essence and preparation method thereof |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102525837A (en) * | 2011-11-08 | 2012-07-04 | 海南光宇生物科技有限公司 | Astaxanthin-containing bacterial cellulose membrane product |
| CN104523483A (en) * | 2014-12-06 | 2015-04-22 | 广州一生美网络科技有限公司 | Antioxidant, anti-aging and anti-radiation eye pad composition and preparation method thereof |
| CN105616176A (en) * | 2016-03-21 | 2016-06-01 | 东南大学 | Phenylethyl resorcinol high-loading lipid nanocapsule and preparation method thereof |
| CN105686961A (en) * | 2016-01-19 | 2016-06-22 | 东南大学 | Pterostilbene nano-capsules and preparation method thereof |
-
2016
- 2016-09-18 CN CN201610828701.3A patent/CN106214501A/en active Pending
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102525837A (en) * | 2011-11-08 | 2012-07-04 | 海南光宇生物科技有限公司 | Astaxanthin-containing bacterial cellulose membrane product |
| CN104523483A (en) * | 2014-12-06 | 2015-04-22 | 广州一生美网络科技有限公司 | Antioxidant, anti-aging and anti-radiation eye pad composition and preparation method thereof |
| CN105686961A (en) * | 2016-01-19 | 2016-06-22 | 东南大学 | Pterostilbene nano-capsules and preparation method thereof |
| CN105616176A (en) * | 2016-03-21 | 2016-06-01 | 东南大学 | Phenylethyl resorcinol high-loading lipid nanocapsule and preparation method thereof |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111388340A (en) * | 2020-04-13 | 2020-07-10 | 上海新高姿化妆品有限公司 | Stable astaxanthin essence and preparation method thereof |
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