JP2003342184A - Hyaluronidase activity inhibitor and cosmetic composition - Google Patents

Abstract

<P>PROBLEM TO BE SOLVED: To provide a new and safe hyaluronidase activity inhibitor and a cosmetic composition. <P>SOLUTION: The hyaluronidase activity inhibitor and cosmetic component are provided by containing 1 kind or ≥2 kinds selected from grape fruit, Japanese pepper and Chinese milk vetch and have the hyaluronidase inhibitory activity for imparting tension and bloom to a skin, and improving wrinkles and sag of the skin. Further, it is possible to improve inflammatory skin diseases (e.g. eczema, an itch, skin roughness, etc.). Therefore it is effective for the prevention of skin aging or dermatitis. <P>COPYRIGHT: (C)2004,JPO

Description

Detailed Description of the Invention

[0001]

TECHNICAL FIELD The present invention relates to a grape leaf,
The present invention relates to a hyaluronidase activity inhibitor containing one or more kinds of plant extracts selected from salamander and lotus root and application to a cosmetic composition.

[0002]

2. Description of the Related Art A typical change in human skin aging is wrinkles and tarmi, which is one of the major skin problems for older people and women. However, at present, most effective treatments for skin wrinkles and tarmi are not found, and various studies on aging have come to be conducted in the aging society.

At present, it is considered that the formation of wrinkles and tarmi on human skin is caused by the decrease in elasticity of the skin. However, as a specific histological phenomenon,
Collagen in the dermis, elastin, changes in extracellular matrix components such as glycosaminoglycans are mentioned, and particularly hyaluronic acid among the glycosaminoglycans is known as a high molecular weight polysaccharide widely distributed in connective tissue,
It retains a large amount of water in the skin and is in the form of gel. Therefore, it is considered that qualitative and quantitative reduction of hyaluronic acid is important in skin aging.

Further, hyaluronic acid is also an important factor for skin inflammation, and it is known that hyaluronidase, an enzyme that hydrolyzes hyaluronic acid, is present. That is, it is considered that hyaluronidase is activated during inflammation, destroys the connective tissue matrix such as hyaluronic acid, and enhances the permeability of cells and blood vessels of the inflammatory system, which is a cause of acute edema. Since it is also used as an agent, inhibiting the activity of hyaluronidase is considered to be effective in preventing skin inflammation.

[0005]

Therefore, the present invention suppresses the activity of hyaluronidase to reduce the water retention function of the skin caused by the decomposition of hyaluronic acid, the skin elasticity / tension / gloss, and the wrinkles and tarmi. It is an object of the present invention to provide an inhibitor of hyaluronidase activity, which is effective in preventing skin aging or skin inflammation, which is said to cause formation or inflammatory skin diseases (eg, eczema, pruritus, rough skin, etc.).

[0006]

[Means for Solving the Problems] As a result of the development in view of these circumstances, it was confirmed that one or more plant extracts selected from grape leaf, salamander, and lotus root extract have a hyaluronidase activity inhibitory action. did. Furthermore, the cosmetic composition containing these improves tension and luster to the skin, or improves wrinkles and tarmi, and further improves inflammatory skin diseases (e.g., eczema, itching, rough skin, etc.). It was confirmed to do. Therefore, the present invention has been completed by providing a novel and safe hyaluronidase activity inhibitor and a cosmetic composition.

[0007]

BEST MODE FOR CARRYING OUT THE INVENTION The "grape leaf" used in the present invention means the family Vitaceae and the genus Vitis.
Plant of: Grape (European Grape) (Vitis vinifera
L.) stems, leaves, branches, and vines can be used, with leaves being particularly preferred. In addition, Korean grapes of the same genus
(Manshuyama Grape) (V. amurensis Rupr.), Yama Grape (V. coignetiae Pulliat), Shrimp Crane (V. ficifolia B)
unge var.lobata (Regel) Nakai (＝ V.thunbergii Sieb.et
Zucc.)), Sankakuzu (V. flexuosa Thunb.), American grape (V. labrusca L.), (V. rotundifolia Michx.),
It is also possible to use a vine (V. saccharifera Makino) or the like.

[0008] The term "salam" used in the present invention means Rutaceae and genus Zanthoxylum.
Plants of: Salamander (Zanthoxylum piperitum DC.) Flowers, spikes, peels, fruits, cones, buds, stems, leaves, branches, branches, leaves,
Stem, bark, rhizome, root bark, root, fruit, pericarp, seed, seed coat or whole plant can be used, but pericarp is particularly preferable.
In addition, Z. ailanthoides (Z.
Sieb.et.Zucc. (＝ Fagara ailanthoides (Sieb.et Zucc.)
Engl.)), American Zanshaw (Z. americanum), Kahokzan Zhou (Z. bungeanum Maxim.), Asakura Zansho
(Z.piperitum (L.) DC.forma inerme Makino), Inuzansho (Z.schinifolium Sieb.et Zucc. (＝ Fagara schin
ifolium (Sieb.et Zucc.) Engl.)) etc. can also be used.

The term "Astragalus sieboldii (also known as astragalus, safflower)" used in the present invention means a plant of the leguminous family (Leguminosae) and genus Astragalus (Astragalus si).
nicus L.) flower, spike, pericarp, fruit, cone, bud, stem,
Leaves, branches, branches and leaves, stems, bark, rhizomes, root bark, roots, seeds or whole plants can be used, but whole plants and seeds are particularly preferable. Other plants of the same genus (A. adscendens Boiss.et Hauss
k.ex Boiss), Purple Momuzuru (A. adsurgens Pal
l.), (A.boeticus L.), (A.caryocarpus Ker-Gawl.),
(A.cicer L.), (A.falcatus Lam.), (A.glycyphyllus
L.), (A.hamomus L.), Astragalus membranaceus
(Fisch.) Bunge), (A.mexicanus DC.), Momendzuru (A.re
flexistipulus Miq.), (A.venosus Hochst.), etc. can also be used.

The extract of grape leaf, salamander, and astragalus used in the present invention is obtained by squeezing various parts of each plant as it is or after crushing. Alternatively, it is extracted with a solvent as it is or after pulverization.

The extraction solvent for the above-mentioned various plant extracts may be selected in consideration of the purpose of use, the type of product to be provided, the processing to be performed later, etc.
Water, lower alcohols such as methanol, ethanol, propyl alcohol, isopropyl alcohol, butanol, isobutanol, etc. or hydrous lower alcohols, propylene glycol, 1,3-butylene glycol, polyhydric alcohols such as glycerin or hydrous polyhydric alcohols, acetone, acetic acid It is desirable to use one or a mixture of two or more selected from various organic solvents such as ethyl. However,
When the inclusion of an organic solvent is not preferable depending on the purpose of use, water alone may be used, or ethanol that is easy to remove after extraction may be used and used alone or in any mixture with water. You can use the extracted one.
Furthermore, it can be used in a state where each solvent extract is combined.

[0012] In addition to the hydrolytic extraction of the above-mentioned various plants by enzymatic decomposition, those hydrolyzed by acid / alkali can also be used.

The production method is not particularly limited, but it is usually within the range of the boiling point of the solvent at room temperature and atmospheric pressure. After extraction, filtration or ion exchange resin is used for adsorption / adsorption.
It may be decolorized and purified to form a solution, paste, gel or powder. In many cases, it can be used as it is, but if necessary, further purification treatment such as deodorization and decolorization may be added within a range that does not affect the effect, and as a purification treatment means such as deodorization and decolorization. It suffices to use an activated carbon column or the like, and any ordinary means generally applied depending on the extraction substance may be arbitrarily selected. It is also possible to add an organic solvent such as ethanol, propylene glycol, 1,3-butylene glycol, phenoxyethanol or the like, or an arbitrary mixture thereof to the extract after extraction. The obtained extract can be used as it is, but can also be used as a paste or powder by concentrating and drying.

The various plant extracts of grape leaf, salamander and lotus root of the present invention can be contained in a hyaluronidase activity inhibitor and a cosmetic composition, and the content thereof is not particularly limited, and a hyaluronidase activity inhibitor, Slightly different depending on the type, quality and expected degree of action of the cosmetic composition. Usually, 0.0001 mass% or more (hereinafter, represented by%), preferably 0.01 to 50.0% in terms of solid content in the total amount of the preparation. good. In the case of bath agents, 200 to 3
It is recommended to consider the prescription so that the same concentration is obtained by pouring it into 00L of bath water.

The hyaluronidase activity inhibitor and cosmetic composition of the present invention may have any dosage form and form, such as capsules, powders, granules, solids, liquids, gels, bubbles, emulsions, creams, ointments and sheets. It can be mixed and used in the form.

The fields of application thereof are, for example, all kinds of external preparations (including preparations used for animals) in general, and specifically, ampoules, capsules, pills, tablets, powders, granules, solids, Liquids, gels, bubbles, emulsions, sheets, mists, sprays, etc. 1) Pharmaceuticals, 2) Quasi-drugs, 3) Topical or systemic skin cosmetics (e.g. Basic cosmetics such as water, emulsions, creams, ointments, lotions, oils, packs, facial cleansers, skin cleansers, massage agents, cleansing agents, depilatory agents, depilatory agents, shaving treatment agents, aftershave lotions, pre-shows Lotion, shaving cream,
Makeup cosmetics such as foundation, lipstick, blusher, eye shadow, eyeliner, mascara, perfume, nail enamel, nail enamel, nail enamel remover, poultice,
Plasters, tapes, sheets, patches, aerosols, etc.), 4) medicinal or / and cosmetic preparations (for example, shampoo, rinse, hair treatment, pre-hair treatment) applied to the scalp and hair. Agents, permanent liquids, hair dyes, hair styling agents, hair styling agents, hair styling agents, hair growth and nourishing agents, poultices, plasters, tapes, sheets, patches, aerosols, etc.) 5) Agents, 6) In addition, axillary deodorants, deodorants, deodorants, antiperspirants, hygiene products, sanitary cotton, wet tissues, toothpaste, mouthwash, mouthwash, etc.

The hyaluronidase activity inhibitor and cosmetic composition of the present invention may optionally contain, in addition to the above-mentioned essential components, the components and additives exemplified below as long as the effects of the present invention are not impaired. Can be selected and used in combination, the content in the formulation is not particularly specified, but usually,
0.0001 to 50% is preferable.

(1) Various fats and oils Avocado oil, almond oil, fennel oil, perilla oil,
Olive oil, orange oil, orange lafa oil, sesame oil, cocoa butter, chamomile oil, carrot oil, cucumber oil, tallow fatty acid, kukui nut oil, safflower oil, shea butter, liquid shea butter, soybean oil, camellia oil, corn oil, rapeseed Oil, Persic oil, Castor oil, Cottonseed oil, Peanut oil, Turtle oil, Mink oil, Egg yolk oil, Palm oil, Palm kernel oil, Mokurou, Palm oil, Beef tallow, Lard, Squalene,
Squalane, pristane or hydrogenated products of these oils (hardened oil, etc.), etc.

(2) Waxes Beeswax, carnauba wax, whale wax, lanolin, liquid lanolin, reduced lanolin, hard lanolin, candelilla wax,
Montan wax, shellac wax, rice wax, etc.

(3) Mineral oil Liquid paraffin, petrolatum, paraffin, ozokeride, ceresin, microcrystalline wax, etc.

(4) Fatty acids Lauric acid, myristic acid, palmitic acid, stearic acid, behenic acid, oleic acid, linoleic acid, linolenic acid,
Natural fatty acids such as docosahexaenoic acid, eicosapentaenoic acid, 12-hydroxystearic acid, undecylenic acid, tall oil, lanolin fatty acid, isononanoic acid, caproic acid, 2-ethylbutanoic acid, isopentanoic acid, 2-methylpentanoic acid, 2-ethylhexane Acids, synthetic fatty acids such as isopentanoic acid.

(5) alcohols ethanol, isopropyl alcohol, lauryl alcohol,
Natural alcohols such as cetanol, stearyl alcohol, oleyl alcohol, lanolin alcohol, cholesterol, phytosterol, phenoxyethanol, 2-
Hexyldecanol, isostearyl alcohol, 2-octyldodecanol and other synthetic alcohols.

(6) Polyhydric alcohols ethylene oxide, ethylene glycol, diethylene glycol, triethylene glycol, ethylene glycol monoethyl ether, ethylene glycol monobutyl ether, diethylene glycol monomethyl ether, diethylene glycol monoethyl ether, polyethylene glycol, propylene oxide, propylene glycol , Polypropylene glycol, 1,3-butylene glycol, pentyl glycol, glycerin, pentaerythritol, threitol, arabitol, xylitol, ribitol, galactitol, sorbitol, mannitol, lactitol, maltitol and the like.

(7) Esters Isopropyl myristate, isopropyl palmitate, butyl stearate, hexyl laurate, myristyl myristate, oleyl oleate, decyl oleate, octyldodecyl myristate, hexyldecyl dimethyloctanoate, cetyl lactate, Myristyl lactate, diethyl phthalate, dibutyl phthalate, lanolin acetate, ethylene glycol monostearate, propylene glycol monostearate, propylene glycol dioleate, etc.

(8) Metal soaps Aluminum stearate, magnesium stearate, zinc stearate, calcium stearate, zinc palmitate, magnesium myristate, zinc laurate, zinc undecylenate and the like.

(9) Gum, sugar or water-soluble polymer compound gum arabic, benzoin gum, dammar gum, guaiac butter, Irish moss, karaya gum, tragacanth gum,
Carob gum, quince seed, agar, casein, lactose,
Fructose, sucrose or an ester thereof, trehalose or a derivative thereof, dextrin, gelatin, pectin, starch, carrageenan, carboxymethyl chitin or chitosan, alkylene (C2-C4) such as ethylene oxide, hydroxyalkyl (C2-C4) added with an oxide. ) Chitin or chitosan, low molecular weight chitin or chitosan, chitosan salt,
Sulfated chitin or chitosan, phosphorylated chitin or chitosan, alginic acid or its salt, hyaluronic acid or its salt,
Chondroitin sulfate or its salt, heparin, ethyl cellulose, methyl cellulose, carboxymethyl cellulose, carboxyethyl cellulose, sodium carboxyethyl cellulose, hydroxyethyl cellulose, hydroxypropyl cellulose, nitrocellulose, crystalline cellulose, polyvinyl alcohol, polyvinyl methyl ether, polyvinyl pyrrolidone, polyvinyl methacrylate, poly Acrylate, polyalkylene oxide such as polyethylene oxide and polypropylene oxide or cross-linked polymer thereof, carboxyvinyl polymer,
Polyethyleneimine etc.

(10) Surfactant Anionic surfactant (alkyl carboxylate, alkyl sulfonate, alkyl sulfate ester salt, alkyl phosphate ester salt), cationic surfactant (alkyl amine salt, alkyl quaternary ammonium salt) ), Amphoteric surfactant:
Carboxylic acid type amphoteric surfactant (amino type, betaine type), Sulfate ester type amphoteric surfactant, Sulfonic acid type amphoteric surfactant, Phosphate ester type amphoteric surfactant, Nonionic surfactant (Ether type nonionic Surfactants, ether ester nonionic surfactants, ester nonionic surfactants, block polymer nonionic surfactants, nitrogen-containing nonionic surfactants, other surfactants (natural surfactants) , Protein hydrolyzate derivatives,
Polymer surfactant, surfactant containing titanium / silicon,
Fluorocarbon type surfactant) etc.

(11) Various vitamins Vitamin A group: retinol, retinal (vitamin A
1), dehydroretinal (vitamin A2), carotene, lycopene (provitamin A), vitamin B group: thiamine hydrochloride, thiamine sulfate (vitamin B1), riboflavin (vitamin B2), pyridoxine (vitamin B)
6), cyanocobalamin (vitamin B12), folic acid,
Nicotinic acid, Pantothenic acid, Biotin, Choline,
Inositols, vitamin C group: vitamin C acid or its derivative, vitamin D group: ergocalciferol (vitamin D2), cholecalciferol (vitamin D3),
Dihydrotaxosterol, vitamin E group: vitamin E or its derivatives, ubiquinones, vitamin K group: phytonadione (vitamin K1), menaquinone (vitamin K)
2), menadione (vitamin K3), menadiol (vitamin K4), other, essential fatty acid (vitamin F), carnitine, ferulic acid, γ-oryzanol, orotic acid, vitamin Ps (rutin, eriocitrin, hesperidin), vitamin U etc.

(12) Various amino acids Valine, leucine, isoleucine, threonine, methionine, phenylalanine, tryptophan, lysine, glycine, alanine, asparagine, glutamine, serine, cysteine, cystine, tyrosine, proline, hydroxyproline, aspartic acid, glutamic acid , Hydroxylysine, arginine, ornithine, histidine, etc., and their sulfates, phosphates, nitrates, citrates,
Alternatively, amino acid derivatives such as pyrrolidonecarboxylic acid.

(13) Various additives derived from plant- or animal-based raw materials These are processed (eg, crushed, milled, washed, hydrolyzed, etc.) in a conventional manner depending on the product type and form to be added. Fermentation, purification, squeezing, extraction, fractionation, filtration, drying, powderization, granulation, dissolution, sterilization, pH adjustment, deodorization, decolorization, etc. are selected and combined), and various materials are selected. You can select it and use it.

The solvent used for the extraction may be selected in consideration of the purpose and type of the product to be provided, or the processing to be performed later, but usually, water, methanol, ethanol, propyl alcohol, isopropyl is used. Alcohol, lower alcohol such as butanol, isobutanol or hydrous lower alcohol, polyhydric alcohol such as propylene glycol, 1,3-butylene glycol, glycerin or hydrous polyhydric alcohol, various organic solvents such as acetone, ethyl acetate, etc. It is desirable to use one or a mixture of two or more of them. However, when the content of the organic solvent is not preferable depending on the application, only water may be used, or ethanol that is easy to remove after extraction may be used and used alone or in any mixture with water, or, Exploited extract may be used.

Additives derived from plant or animal raw materials are
When used as a systemic or topical external preparation, cosmetics, including protection of skin and hair, moisturizing, improvement of touch and texture,
Giving flexibility, alleviating irritation, alleviating stress caused by aroma, cell activation (prevention of cell aging), suppression of inflammation, improvement of skin and hair quality, prevention of rough skin and its improvement, hair growth, hair growth, hair loss prevention, gloss , Cleaning effect, relief of fatigue, promotion of blood flow,
In addition to cosmetic effects such as warm bath effect, fragrance, deodorant, thickening,
The effects of antiseptic and buffer can be expected.

In addition, in foods and drinks, such as nutritional supplementation, recovery from fatigue, tonicity, healthy and cosmetic effects such as cell activation (prevention of cell aging), taste improvement, color tone, aroma and luster impartation, stabilization, It can be used for the purpose of thickening and preserving. In addition to this, expect various various cosmetic and pharmaceutical effects of each raw material known so far, and aim to enhance the desired effect by combining these.
Alternatively, the product can be expected to have a multi-functional effect.

As a concrete plant (crude drug) used as a raw material,
For example, almonds, ai, blue vines
(Seifufuji), Aoki (Aoki), Aogiri or Kenashiaogiri
(Wo Tung), Aozuduraji (Kibo), Aotenma, Acacia, Akasoma (Akasoma), Akasuguri `` fruit '', Red clover, Red grapes, Red amber (Logwood), Red agate wrinkle (Red bud), Red Akane or Akane or Akane (Akane). (Grassroots), Akagia jiou or jiou (ground yellow),
Agi (A Wei), Aki Larch, Akinire (Resin), Aguay Guassu, Aguahe (Amaranthus japonicus), Akebei
(Ki-dori), Asa (Asakojin), Malva Morning Glory or Morning Glory
(Dagushi), Hydrangea (hydrangea), Ashitaba (tomorrow leaf), Azuki (red azuki bean), Asunaro, Acerola, Asenyak (Asenyaku), Athira (Sakuyoukanna), anise, abiu, abiulana, canola, abemaki "fruit" ,Avocado,
Ama, Amacha (Amacha), Amacha Crane, Amadokoro (Tamatake), Amana (Kojin), Amaranthus (Hiyu, Hagatetou, Himegateto, Senninkoku, Sugimorigateu,
Hosoaogatetou, Aogaitou, Haribiyu, Aozulan, Amarantius hippocondriacus), Amigasayuri or Fritillaria (shellfish), Aristromelia (Yurizuisen), Arcana (Arcanna), Algarrobo (Cabbage), Artea, Arnica, Alpinia or Katsumadai
(Souzuku), Aloe (蘆 舆 興), Aloe vera, Angelica, Apricot or hon apricot (apricot kernel), Ansokkou (benzoin), Yellow Zapote, Igakouzorina (Gallery head), Ikariso or Yamachitakarisou (Inyoukaku), Igusa
(Wicked grass), Knotweed (Kojo root), Yew (1st place), Strawberry,
Fig (flowerless "fruits and leaves"), figs (first), hibiscus (winter aoi), Ichiyakuso (one medicinal herb), ginkgo (ginkgo biloba "seed, leaves"), Itohimehagi (distant), locust bean, Inunazuna (Taylexi) , Inubiyu (Honagainubiyu), rice "seed, seed coat", inondo "seed", Echinochloa japonica, nettle, ylang-ylang, iwatobacco (Iwabaki),
Iwahiba or Iwamatsu (wind roll), common bean, oolong tea, fennel (incense), wheat (Chibana), ukiyagara (Sanryo), Uguisukagura "fruit", Himeyokiou, turmeric (Yukin), duckweed (Ukiwa), Usubasaishin Or Keirin saishin or Sengoku saishin (spicy), mussels mallow, mung bean mallow, medusa orchid, nemophilus (summer hay), udo or shishido (invigoration, independence, indonesia), unyadegat (unkalia, cat's claw),
Uba Tea, Ume (Ume "seed, fruit pulp"), Vladimir Ogashira, Argentine (Rawberry), Unshu Mikan (Chenhide), Umboku, Estragon, Ezo-kogi (Ezo Goka), Ezo Suzuran, Echinashi (Hosobamurasakibareniku, Echinashi), Enishi Mushrooms), Ebisugusa or Cassia tora (Keiko), El Campre, Elderberry "fruit",
Elemi, Eryngii or Pre-Lotus erynge, Enju (Sophorae, Sophorae rice), Pea, Ougi or Kibanana
(Yellow radish), Naruco lily or Kagi Kurumabanaruko Yuri (Yellow), Ohihisasanoyuki or Sasanoyuki, Ouren (Yellow), Ogata Houken, Ookarasuri (Calocon),
Plantain (Civil engineering incense), Giant tsuboji (Self-defense), Plantain
(Carmaco, Carophyllum), Milk thistle (Yushu Leopard, Bald Ear), Toucan Hazel (Haruko), Toucan Cactus, Obana Ochera or Ochera (White syrup), Obana Sarsberg (Banaba), Ooba Yashaho "Fruit", "Fruit" Grains), Oomiacatetsu, Omihawthorn or Hawthorn
(Yamashiko), Omiyashi, Barley (barley), Oka, Okazeri (Heiwako), Okra "fruit", Oguruma (overturning), Oklurihigotai (Banzhou Leopard, Indigo Spin), Panax ginseng or Panax ginseng (carrot) , Hypericum perforatum or Hypericum perforatum or Hypericum perforatum (younger brother cut grass), Odorikosou (intermittent), Onami (blue ears), Onigurumi, Onidokoro or Tokoro or Nagadokoro (Hikai), Oninogagara
(Tianma), Oniyuri or Sasayuri or Hakatayuri (yuri),
Onoelan, Ononis, halibut, Ominaeshi
(Soy sauce), Oyuco, Dutch mustard (cresson), Dutch jelly, Dutch millet, Dutch honeywort, olive "fruit, seed, leaf", oregano, orange "fruit, peel",
Kaikaizou (ripe ground yellow), cacao "fruit, peel, seed", oyster (persimmon "leaf"), oyster vine (fishing hook), oyster or citrus root (rensenzo), oyster, hydrangea, cassia, casino ki ( (Fruit `` fruit ''), banyan tree (pepper), oak (camellia tree, camellia leaf), cascarilla, cascara sagrada, gypsophila, kasenso, cypress (Kinshato), kaniwa, carnation, valerian root, hippo,
Birch or weeping birch (birch), gerbera, pumpkin, kapok cypress `` seed '', kahokusansho (shusho),
Cattail, chamomile or Roman chamomile, chamomile
(Grazing), cam cam (duck), karagwa or yamawawa
(Mulberry), color, calyx salmon, crow cucumber or cinnamon cucumber (royal gourd), crow bishaku (half summer), oats, guarana "seed", callahoo (bamboo), karaya, garyu, karin (wood melon), garcinia, kawamidori, kawarasaiko (Koryo greens, white grass), kawajisha, kawaratake, kawaranadeshiko (ishitake) or ezokawaranadeshiko (red wheat, green wheat), kawaran carrot (green garlic), kawara mugwort (seaweed tinchin garlic), kansu (sweetened), kanzo (Licorice), cantara, candelilla, canto, canna, canlan, raspberry (ezo strawberry, dutch strawberry, shrimp strawberry, nawairo strawberry, maple strawberry, european raspberry),
Kiwi "fruit, leaves", squid cucumber (urine root), kyokyo
(Kikyo, Kikyo root), chrysanthemum (Chrysanthemum, chrysanthemum, chrysanthemum), Kikutanigiku, Catalpa (Azusa fruit), Rumex
(Yotei), Kizitsu (Kuromi), Kizuta, Kidachi Aloe, Kudachi Mint, Kina, Kinonaki (Shinkona, Red Kinaki), Quinua (Kinoa), Kihada (Yellow Kashiwa), Kimame, Gymnema sylvestre, Kimenkaku, cabbage, cabbage "unripe fruit" , Caraway, cucumber, gyoryu (Nishikawayanagi, Teiyanagi), Kiraja saponaria, Kiraya, Kiranso (Kenshi small grass), kumquat "fruit", kinkju, ginsekikai, kumbusen, kimuma, kimimizuki (senzuru kusa),
Kinran, Ginran, Kinryohen, Guapaba Vermelha, Guava "Fruit", Guayule, Quercus Infectria (galaxy), Kukui nuts, Kugenumaran, Cuco (lilies, limbs, limbs, cicadas), Kusagikazura Kudzu (Kudzu root), camphor tree, gooseberry "fruit", Xantheng carrot (Yellow lance), Kutiti River, Gardenia (Yamasuko), Kunugi (Garden root), Cupua, Kubeba, Kumazasa, Vermella, Clara (bitter) three),
Cranberry "fruit", chestnut "seed, fruit, astringent skin", curculigo latifolia "fruit", grapefruit "fruit / leaves", buckthorn, black hemlock (rescue required), turtle or kokibana hikoshi or hikikoshi (enrye grass), clove (clove). , Dingka), Gumbai nazuna (Sekimei, Sekimeishi), Keigai (Purple, Ginkgo), Keitou (corolla, corolla), geckavidin, bay (ken laurel), Kenashi sartoriibara (earthen 苓苓), gentiana, genchiana Birds), Kemponashi (Kigushi), Koukisekekoku, Kishikankan (Koji, Tachibana, Obenimikan, Fukuromican, Sagamikouji, Ponkan, Santara (Tachibana peel)), Koushibara (Monthly flowers), Kosui mint, Kozo `` fruit '', Kocha (Black tea), Kouhone (river bone), Kouhon (Straw book, Kara straw) (Book), Kouryan, Kouryoukyo (Kora ginger), Cilantro `` fruit '', Koren (Kuroren), Scutellaria baicalensis (yellow gon), cowberry (Koshitachi), coconut `` fruit '', Goshuyu (Wu 茱萸), Gosho strawberry (Okabonko) , Pepper, cosmos, copaiba balsam, coffee "seed, leaves", kobushi or magnolia (spicy), burdock (burdock, burdock root), koboduzu, sesame (sesame), sesame seedweed (genus), goji (salmon). , Vine vine or vine vine or pine beetle, wheat (wheat),
Rice or rice bran "Aka bran, Shiran bran", rice oil, cola acluminata "seed", cola vera "seed", Coleus Forskoli, Colonia, fenugreek "fruit", Colombo, Conzurango, konbu, konjak, konfuri (fin) Prunus), sisal (sisal asa), saihairan, sakaneran (ezosakaneran), saxima button crane or shining button crane or sinensenninsu (weapon), cherry tree (Oshima cherry tree, Yamazakura, Oyama cherry tree, Edhigashi, bean cherry tree, Miyama cherry tree, Miyama cherry tree, Soyame cherry tree, Soyame cherry tree, Somei cherry tree, Somei cherry tree, Soyame cherry tree, Somei cherry tree, Somei cherry tree, Somei cherry tree, Somei cherry tree, Somei cherry tree, Somei cherry tree, Soyame cherry tree, Soyame cherry tree, Soyame cherry tree, Somei cherry tree, Soyame cherry tree, Soyame cherry tree, Soyame cherry tree, Soyame cherry tree, Soyame cherry tree, Soyame cherry tree, Soyame cherry tree, Soyame tree cherry tree , Kohigan, Satozakura, Kanzakura "leaves, flowers, fruits, bark (cherry bark)"), cherries, pomegranates, sasa, sasabaginran, sasanqua, sadiomodaka
(Sawatari), sweet potato, sugar cane, sugar beet, rapeseed jujube (saccharin), saffron (safflower, west safflower), sapodilla, sapote amariyo, pomelo fruit, savonsou, salmon berry “fruit”, sala cinnamon (masaki), Salan citrus (sand indigo stab), salvia (sage), swordfish (mountain spinach), sour walnut (mountain walnut), Sancactus, Sangre Degrad (croton), Sankusou, Sanshichinengin (37 ginseng), Sanshuyu (Sansuyu) Yamatake mushrooms), Sandscon (mountain bean root), Shea (carite), Cyanoki "fruit", Shiitake mushrooms (Shiitake mushrooms), Shion mushrooms (Shien), Shikakumame, Digitalis, Shikunshi (Shikunushi), Shiso or Aojizo or Chimenjiso or Kamenjizo (Shiso leaf) , Shiso)),
Rosewood, linden, cinnabar cypress, syringa syringa (ream), shimeji (hinshijime, shakashimeji, hatake shimeji, oishiromijime, beech shimeji, honjimeshi, shirotataketake), shimokuren (pepper), shimotsukesaku yam, yam, potato, yam. , Jasmine (Matsurika), Dwarf mustard (Mugimon winter), Jurassic cowpea, Gypsophila paniculata, Shukshamitsu (sand kernel, crimped sand), Juzudama, palm "fruit", Shunran, Rhodo palm, ginger (ginger), Hydrangea hydrangea (Tsuneyama), Shobu (iris, iris root), Shozuku "fruit", white oak "seed", Silane (Billacquer), White-billed butterfly "seed", White clover (White clover), White adzuki bean
(Chicken bone grass), Shilobana iris (Nileus iris), Shirovanatsuta "flower", Shirobana lupine, Shirominanten (South Tenmi), Cinchona Succibula, Jinchoge (Ruikan, Zuiyoka, Chichobana), Cinnamon, Cinnamoum cassia (cinnamon skin) , Watermelon (watermelon), honeysuckle (gold and silver flower, Shinobi winter),
Sorrel (acidic), swim berry "fruit", star apple, stevia, strawberry "fruit", Suzuko (Lord Xu), horsetail (question), purslane (horse toothpaste, horse tooth machete), plum fruit "fruit", surugaran (Oran), Pinus sylvestris "cone", Larch arbutus, Astragalus vulgaris, Walnut, Hawthorn vulgaris, Vaccinium vulgaris, Dandelion vulgaris, Horse chestnut (Maloneni),
Pear "fruit", Snow flake, Elderflower (Elder), Horsetail (Juniper, Juniper), Sawmilli (Milfoil), Sardine rose, Steller's butterfly, Stunted mistletoe, Stuffed minnow or Steller's wreath, Horseradish, Sperm (Ishikon), Sekoku (Sakura Sekoku,
White-faced, White-faced, White-faced, Hong-sided, Red-faced, White-sided, Yellow-sided) (Dendrobium, Ishibune), Cedron (bowshuboku), Zeniaoi, Hirohase-nega, Senega, Seri, senkyu, celery, senkyu, celery, serikyu (Shinshinren), Sendan, Sennin Cactus, Senna "Fruits, Leaves", Senninsou (Taiwan), Senburi (Origin),
Senboku, soka (grass fruit), elephant chow, soy sauce, buckwheat "seed seed", some potatoes, broad beans, rhubarb
(Daihuang), radish, soybean, daidai (orange peel, minami), takasago rurigogotai (south indigo indigo), takasaburo (drought lotus), takatodai (daisaku), takawarabi (gupin), dark sweet cherry `` fruit ,, hollyhocks, pearl oysters (thyme, lily of the valley), sea bream (hikai), willow, willow, tamarind "seed", onion, tamshiba (spicy), taranoki "fruit, leaves, root bark", tarayou (large leaf winter blue, single leaf tea,
Ditching tea, bitter tea), dahlia (tenjiku button), tarui, tankimimame, tanchiuchiwa, tanjin (danshen), dandelion (Kankouei) or Shirobana dandelion or moco dandelion, danmaru, cherry "fruit", chigaya "fruit, root,"
Bud, Chixet carrot (Chicken ginseng), Chicory, Chanka piedra (Kidachikansou), Tulip, Choconostay, Korean thistle (Artichoke), Korean pearl oyster (Large yellow), Korean elm (Mushroom), Korean ginseng (Agar leaf) , Choreimaitake (boiled boar), Chorogi, Tsukisou, Tsukusakakaneran, Tsukutake mushroom (Mushroom), Tsuchiakebi, Camellia, Camellia japonica, Tsumekusa (lacquer grass), Tsuyakusa (duckweed grass), Tsuzukizuki (red adzuki bean),
Pleurotus chinensis, Pleurotus cornucopia L., Tsuruna (Apricot), Ginseng (Folia ginseng), Glycine soja, Tsuwabuki, Deiko, Teuchigurumi, Duberry "fruit", Agargus,
Tencha (Japanese tea), Tendaiyaku (crow), Toga (winter gourd), Tokajikazura, Capsicum (Pepper), Touki (Tomeki), Capsicum (Marigold), Toukikachi, Tounabena (river cut), corn or corn Hair (nanban hair), squirrel mochi (sadako), gentian or dwarf gentian (dragon gall), horsetail (wood bandit), dokudami
(10 medicines), turmeric (root), horsetail or bean bug or weevil, Eucommia vulgaris (Musaka "bark, leaf, root"), ash
(Qin skin), tomato, tragacanth, triacanthus `` seed '', eustoma, turmentula, doronoki, troor mallow, peanut, nigerian berry `` fruit '', yam or yam (mountain drug), nagikadada (butcher bloom), naginata koju, nazuna, Rapeseed, peanut or horizontal sticker (sword bean), jujube, jujube (large jujube),
Naniwaibara (Kinzako), Navena (interrupted), Nameko, Peanut (peanut), Nanten (Namitenmi), Nanban Karamushi
(Cara hemp), iosum violet, nigaki (Bitterwood), sagebrush (Bitterwood), nutmeg, Kei or Nikkei or Ceylon Nikkei or Yabunikei (cinnamon bark) or Keishi (Keishi), Nyohakudo, Chinese chive (Nishiko), Elderberry (bone skeleton) Tree "fruit, flower,
Stems, leaves "), garlic (garlic), nurude (quintile), leeks,
Nemoki or Nebu or Nebi or Nemuriki or Jigokubana (Joint reception), Thistle (Oyagi), Noibara (Fruit), Nosyllium chinensis (Ryoshu), Nogetou, Yarrow, Nodoke
(Former Hu), Novara, Peach, Pineapple `` Fruit '', Hibiscus (Bussouge, Furinbussouge, Roselle), Hylindo, Hauchiwa, Pau Doce, Hakamauraboshi (Hypercutting), Hakukayumato, Hakusanchidori,
Hakusen (tinea bark), Huckleberry "fruit", chickweed (prosperous), Hazel (Haruko), Hashiridokoro (roth root), basil, lotus (lotus, lotus meat, lotus root), parsley (Netherlands jelly), hadakamugi, batata, hachiku Or madake (boiled bamboo), patchouli, peppermint (light load, light load), hazelnut, pearl barley
(Yokuinin), Hanasuge (knowledge mother), banana, Hana mint,
Hanabishi (Shitsuri, Shishitsuri), Vanilla Bins, Papaya, Yellow-footed squirrel (mouse koji), Pahalobobo, Hub "Whole grass,
`` Stems, leaves '', paprika, oyster oysters, sesame or honeywort (vine vine), pipiens (kabushi), yamabishi (shitsuriko), hamanasu (maikai flower), hamaboufu (hama windbreak), hamamelis, palm, rose (rose) , Balata, balata gum, agaricus (agaricus, white-bellied agaricus, Uskimorinokasa), harlan, paliurus (Haimamatsume), parietalia, harukanran, balsamina (vine pickles, bitter melon), harunire (wooden bark, bark bark, mubari bar) Harlin Do, Handai Kai
(Katsu Omi), Panoki, Hyogi (Sho-ho), Leek Carrot (Party Participant), Pecan Nut, Higanbana (Ishigaru, Urusu Sasa), Higulmadaria, Higotai, Hishi (Hishimi), Pistachio, Beet, Hittsuba (Stone) Reed), Aedes aegypti,
Daisies (daisies), Hinako no Kozuchi (cows), Hydrangea cypress, cypress, hiba, castor, sunflower, peppers,
Himeuzu (Aoi), Himegama (Agaricus), Himematsutake (Kawariharatake, Hiromatsutake), Himemu Orchid, Pimenta "fruit", juniper, juniper, juniper "fruit",
Chickpeas, lentils, velvet aoi, pearl oysters (Bald Ears), loquat "fruits, leaves, stems", betel nuts (large skin, calyx), Pu'er tea, Futoukazura (nantan), butterburs, butterbur winter flowers, winter winter leaves ), Fujibakama (Orchid grass), Fuji bean (Foliar bean), Fujimodoki (Chrysalis japonica, cypress), Grape `` fruit, pericarp, seeds '', beech, Fuyusuminatsukutaketake (caterpillar), Brazilian licorice, Brazilian carrot, Brazilian palm, Brazilian elephant Hayashi, black currant "fruit", blackberry, branen,
Plum "fruit", fluceraria, blueberry (Prunus vulgaris), prunes, floral blanka, blonde psyllium, bundou (mung bean), hazelnut, loofah, hetkaran, safflower (safflower), Henneken, belladonna, berry "fruit", persea, pervian Berg,
Pereskia grandifolia, Bengal grass or duckweed (Keiten), Boysenberry `` fruit '', broomwood or sageweed or Nendou or Hahakiki kokia (ground silk),
Houssairan, Housengka (Fengxian, acute child, skeleton grass), Pouteria sapota, Pouteria lucuma, honoki, spinach, physalis (Torone), honoki (Japanese koboku,
(Park), bokeh (wood melon), buckwheat abragiku (bittersweet), buckwheat glutinosa, buckwheat okera (blue), buckwheat giraffe
(Keiten Sanshichi), Hosobabarengiku, Bodaiju (Bodhiju),
Button (peony `` flower, leaf, stem, bark ''), button pie (peony skin), hop, jojoba, borigy (lulichisha), bordeaux, whiteberry berry `` fruit '', hononiku (meat juyo, art), honsekoku ( Tetsuseki Ishi, Suzuyama Ishi), Maizuru Tennan Show (Tiannansei), Maitake (Maitake), Maou
(Mao), maca, macadamia nuts, margaret (moksungiku), macri (marine grass), magui (mulberry bark "bark,
Leaves ''), Magnolia splengeri, Masalanduba,
Masalansuba de Ceara, Masheila de Boi, Mashua (Tamanouzenhallen, Kyukonkinrenka), Matatabi (Tate Taki), Matsukasa, pine "leaf, bark,
Root ", Matta Orho, Matsuhodo, Matico
(Cordon sillo), Mayoram (hanahanakka), Malvano jadine (bitter ginseng), Mulberry "fruit", quince, malein (biloud moose), mango, mangosteen,
Manzanya (Andean chamomile), Manshugurumi,
Mandarin "Fruit", Ganoderma lucidum (Ganoderma lucidum), Pheasant (Fructus "Fruit"), Mishima Psycho (Saiko), Water plantain or Water morning glory (Rhinoglossus), Water stag beetle (Hanbian lotus), Misohagi
(Senkyaku), Michiyanagi or Niwayanagi (Hen), Mitsugashiwa, Mitsuba, Midori Zapote, Midorihaka, Mimosa, Mioga, Miracle Fruit "Fruit", Myrrh, Mirobalan, Strawberry, Mukuge (Makigaki), Mukunoki, Makuji
(Prolonged skin), munya, purple (purple root), purple or purple pearl (purple), purple corn,
Purple fuji wisteria (Kunming chicken blood wisteria), Megakansa opuntica, swordfish (marshmallow grass), medusa, evening primrose
(Evening primrose), Melaleuca, Melissa, Melirote, Melon "fruit", Mugwort, Misouchiku, Mokkirin,
Mojé (pepper), holly, mokko (woody incense), maple peach, peach (peach "leaf, seed, flower, fruit"), coconut, morello cherry "fruit", morohaya (burlap), Yawakawamurasaki, Yakuchi (Yasuchi), cornflower (cornflower), cornflower, yakon, yaba santa, yashabushi (arrow wheel) or Himeyashabushi or Oyabayashabushi "fruit, fruit skin, fruit ear", willow willow, yamde
(Octagonal metal plate), mistletoe (willow parasitic), willow (kawayanagi,
Willow, weeping willow, red willow, pussy willow, dogwood willow, willow willow, cory willow, unryow willow, willow willow, palm, willow willow, willow willow, weeping willow, leaf willow, dragonfly, willow, stem, willow, stem, willow
(Purple gold beef), yab tobacco (Tsuru, Tenmeisei), pokeweed (Shokuriku), yamahanoki (Yamaharu), bayberry (Yangmei skin), yamamogimo, eucalyptus, Yukinoshita (tiger ear grass), yucca or flavifolia, yuzu `` "Fruits", lilies, yellow sedges, mugwort (leaf buds), ligans (thunder maru), lime "fruits", rye, lakanka "fruits", raspberries "leaves, fruits", latania (clameria), lacquer or shallots (flasks), lavender. , Longan (dragon meat), agave (Aono agave, fukurin agave),
Ryokucha (green tea), apple "fruit, seed, leaf, root", gentian, rubus or Suavesimus (hushun), thistle (this is Vladivore Higotai, Xinjiang indigo head), litchi (lunch, leek branch), lettuce (chisha) , Red currant "fruit",
Red pitaya, lemon "fruit", lemongrass, forsythia or Chinese forsythia (ream), waxy (wax plum), wax palm, locon (reed, root), loganberry "fruit",
Rosemary (mannen wax), rose hips (novara),
Examples include wasabi, cottonweed (Japanese sage flower), and fireweed (earthen).

Examples of seaweeds include seaweed [green algae: Chlorella vulgaris, Chlorella pyrenoidosa, Chlorella ellipsoidia, aonori (usubaaonori, sujiaonori, hiraaonori, bowaonori, hosoedaonori), anaosaa (sea algae), Kind: kelp (Macombus, liquorice, Hosomekonbu, Mitsuishikonbu), wakame, hirome, aowakame, giant kelp (macrocystis pilifera, macrocystis integrifolia, neocitrus ruetokeana), hijiki, hibamata, sea uchiwa, usubaumiu Kirebanoumiuchi, Akabatumiuchi, Konaumiuchiwa, Okuchiuchiwa, Usuyukiuchiwa, Echiukiumiuchiwa], Seaweed [Red algae: Hijirimen, Hakusa, Hirakusa, Onik , Obakusa, Kataobakusa,
Yatabegusa, Yukigiri, Amanita, Tosakanori, Togekirinsai, Amaxakirinsai, Giraffe, Jakushinkirinsai, Tsunomata, Obatatsunomata, Tochaka (Nyakuzuna-no-Tomashita), Ezotsunomatsuta, Togenomata, Hirasakonotoma, Kotobuki, Kotobuki, Kotobushi
[Yaleus Banori, Kagious Banori, Suzius Banori, Haius Banori, Akamomijinori] and the like.

In addition, other algae such as green algae (Chlamydomonas: Chlamydomonas, Akayukimo, Dunaliella: Dunaliella, Chlorococcus: Chlorococcus, Qualmomim: Quanonimo, Volvox: Ohigewawari, Volbox, Palmera, Yotsumeu, Genus Aomizu: Hizaori, Ao-shiro, Tsurugi-Midoro, Hibi-Midoro: Hibi-Midoro, Aosa Genus: Anaaosa, Amiosa, Nagahaosa, Kawanori: Kawanori,
Fruicula genus, Shiogusa genus: Oenothera genus, Asamidoriushigusa, Kawashiogusa, Marimo, Baronia genus: Tamagobalonia, Tamabaronia, Magatagum genus: Magata, Iwachia genus: Fusaiwaduta, Black squirrel, Mildewer, Black millet, Nematoda, Hagemonia, Nematoda. Sakibutimir, Nagamir, Hiramiru, and Kasanori:
Casanori, genus genus: Futozuzumo, Tamazuzumo,
(Mizujuzumo, Mikadzuki genus, Colecaete genus, Tsudumimo genus, Kikkokusa genus: Kikkokusa, Astragalus genus: Hitogusa, Hirohanohitohegusa, Usutoegusa, Motukihitoe, Sayamidoro, etc.

Blue-green algae (genus Suizenjinori: genus Suizenjinori, genus Algae, genus Nostoc: Kawatake, Nostoc commune,
Hassai, genus Yuremo, racenmo (spirulina) genus: spirulina, trichodesmium (aia cacio), etc.).

Brown algae (Pyraera: Pyraera, Shiomidoro: Nagamisio Midoro, Isogrape: Isogrape,
Genus Isogawara: Isogawara, Kurogashira: Gunsen Kurogashira, Kasakizaki: Kazakizaki, Muchimo: Muchimo, Hiramuchimo, Keperigusa, Astragalus: Astragalus, Sakibirohajiza, Sanyuhajihadosa, Azagusa saga: Common sage: Common clover, Common clover Prickly squirrel, Ulaboshihaha, Symphalida: Symphologus, Cyperus genus: Cyperus cypress, Konaumi uchiwa, Akabayumi uchiwa, Namikura genus: Prunus chinensis, Somexaceae genus: Somenaceae
Pinus genus: Matsumo, Nagamatsu genus: Nagamatsu moth, Okinawa mozuku genus: Okinawa mozuku, Niceft mozuku genus: Physcomit genus, Physmozuku genus: Physcomitum genus: Genus mosquito: Genus mosquito: Genus moss, Genus moss Isige, Iroro, Ichimegasa: Ichimegasa, Calligraphy: Calli, Umibosu: Umibosu, Urushigusa: Urushigusa,
Black cypress, Tobacco bug, Genus: Haemorium, Haberdoki: Haberodoki, Havanori: Havanori, Habernori: Hazelnut, Common genus: Common butterbur, Ezoburo genus: Nematode: Nephila, Rhizophora, Rhizophora, Rhizophora, Rhizophora, Rhizophora, Pleurotus vulgaris Genus Kagomenori: genus Kagomenori, genus Muralis: murachidori, genus Phalaenopsis: shark
Sardine: Sardine, Asclepias: Asclepias, Kayamonori: Kayamonori, Fennel genus: Fennel, Tsurumo: Tsurumo, Anata: Squirrel, Susume: Aedes albopictus, Missus konjac, Miscanthus, Aedes radisculent, konjac beetle, konjac beetle, scutella conserved , Onikonbu, Goheikonbu, Nagakombu, Pea kombi, Otojijimokubu, Tororokonbu genus: Tororocombu, Antocume: Antokume, Kajime: Kajime, Tsuruarame, Kurume, Chrysanthemum genus: Chrysanthemum genus: Necrochamus genus, Black konjac genus, Black locust, Black civet, : Catfish,
Genus Alame: Alame, Ainu Wakame, Ainu Wakame, Chigaiso, Oniwaka Ezo Ishige: Ezo Ishige, Yabanemoku: Yabanemoku, Rappamok: Rappamok, Jolomok: Ugananomoku, Jolomok, Hiemoku, Honduramaku, Isamanidae, Tamanashira Akamoku, Shidamok, Hondawara, Nejimoku, Narasamo, Mametawala, Tatsukuri, Yasumatamok, Umitranano, Obamamok, Fushizushimok, Hahamok, Togemoku, Yoremoku, Sugimurakoku, Sugimurakoku, Sugimurakoku, Sugimoku, Sugimoku, Sugimoku
Burukkimo, genus Kayamonori: Kayamonori, etc.).

[0039] Red algae (genus: Kensuke Nori, Funori Nousuke, genus Magnolia: Asakusanori, Susabinori,
Upruinori, Onia manori, Tasa, Fuiritha, Benitasa, Rhodocorton: Milnobeni, Akebono Mozuku: Akebono Mozuku, Konahada genus: Hikonahada, Yogorekonahazukuni Azukuniboku, Azusa konjac, Azusa konjac, Azurus chinensis, Azurus chinensis, Azulina serrata, Azurus serrata, Scorpionaceae. : Pine pine, Fusanori genus: Fusanori, False genus: False genus,
Genus Sodegari: Sodegarami, Rattle Genus: Rattle, Rattle, Hilotatamaidae: Hirohatamai Taki, Tamai Taki: Tamai Tadaki, Kagenokiri: Kagaminori, Kaburi, Hibachi, Hibachi, Hibachi, Hibachi, Hitenagao, Hitengusa, Hitenagasa, Hitenagasa, Hitenagai Genus: Hihibiroud, Hibihibiroud,
Pteridophytes: Pleurotus, Pleurotus: Pleurotus: Rumex, Ryumonsou: Ryumonsou, Hera Ryumon, Nymphalaceae: Nisekarekigusa: Okitsubara genus: Psyllium syllabus: Acacia
Naminohana, Coral Spodoptera: Rattlefish, Shiogusagoromo: Shiogusagoromo, Ivanoka genus: Etsukiiwanokawa, Kainokawa: Kainokawa, Kanitonote: Kaninote, Corydalis, Dendrobium, Scutellaria, Dioscorea, Rhizophorus, Scutellaria, Saccharomyces , Tambanori, slippery,
Fudaraku, Maruba Hudarak, Isonohana: Nurakusa,
Black knuckle, Ginkgo biloba, Japanese quince: Japanese quince, Japanese quince, Japanese quince, Japanese quince, Japanese quince, Japanese quince, Japanese quince, Japanese pine tree, Japanese pine tree Nagaobane genus: Nagaobane,
Genus: Hanafunori, Fukurofunori, Mafunori, Kaligukisa: Pachydermia japonicum, Podocarpus genus: Hosobanotokaomodoki, Hirohanotosakadoki, Yatsudegatatokadoki, Kurotosakatodoki, Katodoki, Katodoki, Katodoki, Katodoki Doki,
Himetosakadoki, Kinuhada genus: Kinuhada, Ezotosaka: Ezotosaka, Tsukasanori: Enashikarimenia, Otsukasanori, Hanagatakarimenia, Honoo: Honoo, Hichinagenasu, Nihonbunio, Nihonburonoo Pleurotus cornucopia, Okamuragusa:
Yamadagusa, Mirin: Mirin, Hosobamirin, Tosakanori: Kikutosaka, Ezonameshi: Ezonameshi, Isomokka: Isomokka, Yukari: Yukari, Hosoyukari, Ibaranori: Ibaranori, Saidaibara, Tachiibara, Kadikio Nori, Phytophthora alba Spodoptera litura, genus Astragalus: Astragalus,
Genus Ogonori: Ogonori, Cranegrass, Shiramo, Ozonori, Mizookonori, Cabana Nori, Beniogonori, Fukuroshinonori, Muranosakinogoonori, Scorpionaceae, Scutellariae, Scorpionoris , Astragalus genus: Noctuidae, Fushikrenori genus: Fushiklenori, Pleurotus genus: Pleurotus edulis, Cyprinidae: Pseudonoptera, Periwinkle genus: Periwinkle, Prunus genus: Pteris genus: Simi, Hedgehog, Lotus japonicus
Lotus japonicus, Scutellaria: squid reeds,
Novonori, Black-headed genus: Black-headed ginsou, Red-headed genus: Red-headed ginsou, Rhizoma genus: Hishibukuro, Madaragusa: Scutellaria, Etsukimadara, Taogo-nagien: Taogosou, Hanasakura, Haduna, sugi , Hiratao goat genus: Hiratao goat, dalus genus: dalus, scorpionfish, anadalus, weebagsa genus: weebagsa, benifukuronori genus: benifukuronori, fushuna genus: fushunagi, himefusutsunagi,
Broadbill, Salix genus: Spodoptera cinerea, Usbawa vulgaris, squid genus: squid, caygis, squid squid, haneigis, axusa, egonori:
Egonori, Futogigis, Saeda: Saeda, Chirimomimushi: Chirimomiji, Konohanori family: Hatabenoori, Konohanori, Suzuronori, Usubini: Usbeni, Hasugiginu: Hasujiginu, Nagausaginohagi, Hausaginohagi, Hausaginohaji, Niusakonohaji, sugi-nosagi, sugi, sugi Yaleus Banori, Suzius Banori, Haius Banori, Usbanorimodoki: Usbanorimodoki, Ayanishiki: Ayanishiki, Agianu:
Ayaginu, Dasia genus: Enashidasia, Shimadsia genus: Isohagi, Shimadaia, Dagimodi: Dagimodoki, Itogusa: Moroitogusa, Futoigusa, Makuri: Makuri, Yanaginori genus: Hana-yanagia, sagiyunayunayunayunayunayunayunayunabenyi, benna : Crosozo, Cobosozo, Hanesoso, Sozonohana, Amaranthus: Ranunculaceae, Raponica, Cozanemo: Cozanemo, Imurasaki, Hosocozanemo, Genus: Mesothraceae, Black-spotted dragonfly, Anemoneaceae, Anemoneaceae, Anemoneaceae, Anemoneaceae, Angustiaceae, Angustiaceae, Angustiformes Astragalus, Rhizophora: Rhododendron, Fujimatsumo: Fujimatsumo, Saw-toothed genus: Haeda Mushroom iris, Kawamozuku: Kawamozuku, A Kawamozuku, Himekawamozuku,
Ideyugogome genus: Ideyukogome, Ochiimozuku genus: Ochiimozuku, Otomogusa, Chichinorimo: Chinorimo, Chisujinori: Chisujinori and the like).

Axis algae (genus Chara, genus Citra,
The genus Hositchurimo: genus Hositchurimo, genus Lichnotamnus, genus Flaskula: genus Flaskula, Chaboflask, genus Tripera), yellow algae (genus Hikarimo: Hikarimo, etc.) and the like.

Materials derived from animal-derived materials include poultry extract, cow or pig, human placenta extract, cow or pig stomach, duodenum, intestine, spleen extract or decomposed product thereof, cow or pig. Brain tissue extract, collagen hydrolyzate (acid, alkali, enzyme, etc.) of cattle / pig or fish, collagen derivative such as water-soluble collagen or acylated collagen, elastin or hydrolyzate of cattle / pig or fish (Acid, alkali, enzyme, etc.) or water-soluble elastin derivative, keratin and its degradation product or their derivatives, silk protein and its degradation product or their derivatives, pig or cow blood cell protein degradation product (globin peptide), cattle or Pig hemoglobin degradation products (hemin, hematin, heme, protoheme, heme iron, etc.),
Milk, casein and its degradation products or their derivatives, skim milk powder and its degradation products or their derivatives, lactoferrin or its degradation products, chicken egg components, fish meat degradation products, nucleic acid-related substances (ribonucleic acid, deoxyribonucleic acid), etc.

As the material derived from plant or animal raw materials, any site derived from a gene recombinant or a cell fusion,
Cells, tissues, organs, metabolites, etc. can also be used.
Furthermore, for example, an undifferentiated cell group, a cell group in the process of differentiation, etc., which are obtained by culturing cells at arbitrary sites, cells, tissues, organs, etc. can also be used.

(14) Marine components Seawater such as deep water, for example, seawater salt, dried seawater, inorganic salts (sodium chloride, magnesium chloride, potassium chloride, etc.) obtained from the Dead Sea or the Atlantic or Pacific oceans, sea mud Or mud (fango), for example, sea mud or mud of various places such as Italian fango, German fango, Eifelfango, and Freiburgfango (containing components: silicon dioxide, titanium dioxide, aluminum oxide, iron oxide, manganese oxide, sodium oxide, Potassium oxide, magnesium oxide, calcium oxide, strontium oxide, sodium, potassium, magnesium, calcium, chromium, iron, copper, nickel, zinc, lead, manganese, arsenic, water), Seitoku stone, Kurodaite, etc.

(15) Microorganism culture metabolite Yeast metabolite, yeast extract, bacterial metabolite, bacterial extract, mold or actinomycete metabolite, mold or actinomycete extract, natto metabolite, natto extract, Fermented rice extract,
Fermented rice bran (red bran, white bran) extract, euglena extract or its decomposition product or water-soluble derivative thereof, trehalose or its derivative, lactic acid fermented product of raw milk or skim milk powder, fermented product of lactic acid bacterium of legumes, lactic acid bacterium of coconut plant Fermented material, etc.

(16) α-hydroxy acids Glycolic acid, citric acid, malic acid, tartaric acid, lactic acid, etc.

(17) Inorganic pigments Silicic anhydride, magnesium silicate, talc, kaolin,
Bentonite, mica, titanium mica, bismuth oxychloride, zirconium oxide, magnesium oxide, zinc oxide,
Titanium oxide, calcium carbonate, magnesium carbonate, yellow iron oxide, red iron oxide, black iron oxide, Gunjou, chromium oxide,
Chromium hydroxide, carbon black, calamine, etc.

(18) Ultraviolet absorbing / blocking agent Benzophenone derivative (2-hydroxy-4-methoxybenzophenone, 2-hydroxy-4-methoxybenzophenone-
5-sulfonic acid, sodium 2-hydroxy-4-methoxybenzophenone-5-sulfonate, dihydroxydimethoxybenzophenone, sodium dihydroxydimethoxybenzophenone-sulfonate, 2,4-dihydroxybenzophenone, tetrahydroxybenzophenone, etc.), paraaminobenzoic acid derivative ( Paraaminobenzoic acid, ethyl paraaminobenzoate, glyceryl paraaminobenzoate, amyl paradimethylaminobenzoate, octyl paradimethylaminobenzoate, etc., methoxycinnamic acid derivatives (ethyl paramethoxycinnamate, isopropyl paramethoxycinnamate, etc.)
Octyl paramethoxycinnamate, 2-ethoxyethyl paramethoxycinnamate, sodium paramethoxycinnamate, potassium paramethoxycinnamate, mono-2-diparamethoxycinnamate
Glyceryl ethylhexanoate, etc.), salicylic acid derivatives (octyl salicylate, phenyl salicylate, homomenthyl salicylate, dipropylene glycol salicylate,
Ethylene glycol salicylate, myristyl salicylate, methyl salicylate, etc.), anthranilic acid derivatives (methyl anthranilate, etc.), urocanic acid derivatives (urocanic acid, ethyl urocanate, etc.), coumarin derivatives, amino acid compounds, benzotriazole derivatives, tetrazole derivatives, imidazoline Derivative, pyrimidine derivative,
Dioxane derivative, camphor derivative, furan derivative,
Pyrone derivative, nucleic acid derivative, allantoin derivative, nicotinic acid derivative, vitamin B6 derivative, umbelliferone, esculin, benzyl cinnamate, cinoxate, oxybenzone, dioxybenzone, octabenzone, thrisobenzone, benzoresorcinol, arbutin, guaiazulene, shikonin, baicalin, Baicalein, berberine, neoheliopan, escarol, zinc oxide,
Talc, kaolin, etc.

(19) Whitening agent Para-aminobenzoic acid derivative, salicylic acid derivative, anthranilic acid derivative, coumarin derivative, amino acid compound,
Benzotriazole derivative, tetrazole derivative, imidazoline derivative, pyrimidine derivative, dioxane derivative, camphor derivative, furan derivative, pyrone derivative,
Nucleic acid derivative, allantoin derivative, nicotinic acid derivative,
Vitamin C or its derivatives (vitamin C phosphate magnesium salt, vitamin C glucoside, etc.), vitamin E or its derivatives, kojic acid or its derivatives, oxybenzone, benzophenone, arbutin, guaiazulene, shikonin, baicalin, baicalein, berberine, placenta extract. , Ellagic acid, lucinol, etc.

(20) Tyrosinase activity inhibitor Vitamin C or its derivative (vitamin C phosphate magnesium salt, vitamin C glucoside, etc.), hydroquinone or its derivative (hydroquinone benzyl ether, etc.), kojic acid or its derivative, vitamin E or Derivatives thereof, N-acetyltyrosine or its derivatives, glutathione, hydrogen peroxide, zinc peroxide, placenta extract, ellagic acid, arbutin, rucinol, silk extract, plant extracts (chamomile, mulberry, gardenia, spruce, oleander,
Clara, mugwort, honeysuckle, yellowfin, duckweed, matsuhod, pearl barley, syringa, hops, hawthorn, eucalyptus, yarrow, altea, keihi, mankeishi, hamarisu, karaguawa or yamgua, enryakushi, bellflower, toshishi, zaiko, ejaculate Mahuang, senkyu,
Dokatsu, Psycho, Bow-fu, Hama-bo-fu, Oogon, Peony skin, Peonies, Geno-shoko, Kakkon, Licorice, Quintuple, Aloe, Shouma, Safflower, Green tea, Black tea, Asakuyaku) etc.

(21) Melanin dye reducing / decomposing substance Phenyl mercury hexachlorophene, mercuric oxide, mercuric chloride, hydrogen peroxide solution, zinc peroxide, hydroquinone or its derivative (hydroquinone benzyl ether)
etc.

(22) Turnover promoting action / cell activating substance Hydroquinone, lactic acid bacterium extract, placenta extract, ganoderma lucidum extract, vitamin A, vitamin E, allantoin, spleen extract, thymus extract, yeast extract, fermented milk extract, plant extract (Aloe, dragonfly, horsetail, gentian, burdock,
Sikon, carrot, hamamelis, hop, yokinin,
Odorikosou, Assemblies, Touki, Scalendula, Amacha, Hypericum, Cucumber, Prickly Pear,
Mannenrou, parsley) etc.

(23) Astringent succinic acid, allantoin, zinc chloride, zinc sulfate, zinc oxide, calamine, zinc paraphenolsulfonate, potassium aluminum sulfate, resorcin, ferric chloride, tannic acid (including catechin compound), etc. .

(24) Active oxygen scavenger SOD, catalase, glutathione peroxidase, etc.

(25) Antioxidant Vitamin C or salt thereof, stearic acid ester, vitamin E or derivative thereof, nordihydroguaselethenoic acid, butylhydroxytoluene (BHT), butylhydroxyanisole (BHA), hydroxytyrosol, Para-hydroxyanisole, propyl gallate, sesamol,
Sesamorin, Gossypol, Propolis etc.

(26) Lipid Peroxide Production Inhibitor β-Carotene, Plant Extract (Sesame Cultured Cells, Armature,
Hypericum, Hamamelis, Clove, Melissa, Crassulaceae, Birch, Salvia, Mannenrow, Nantenmi, Ages, Ginkgo, green tea) etc.

(27) Anti-inflammatory agent Ictamol, indomethacin, kaolin, salicylic acid, sodium salicylate, methyl salicylate, acetylsalicylic acid, diphenhydramine hydrochloride, d-camphor,
dl-camphor, hydrocortisone, guaiazulene, chamazulen, chlorpheniramine maleate, glycyrrhizic acid or its salt, glycyrrhetinic acid or its salt, licorice extract, shikon extract, agets extract, propolis and the like.

(28) Antibacterial / sterilizing / disinfectant acrinol, sulfur, calcium gluconate, chlorhexidine gluconate, sulfamine, mercury chrome, lactoferrin or its hydrolyzate, alkyldiaminoethylglycine chloride solution, triclosan, sodium hypochlorite, Chloramine T, porridge powder, iodine compound,
Iodoform, sorbic acid or its salt, propionic acid or its salt, salicylic acid, dehydroacetic acid, parahydroxybenzoic acid esters, undecylenic acid, thiamine lauryl sulfate, thiamine lauryl nitrate, phenol, cresol, p-chlorophenol, p- Chloro-m-xylenol, p-chloro-m-cresol, thymol, phenethyl alcohol, O-phenylphenol, Irgasan CH3565,
Halocarban, hexachlorophene, chlorohexidine, ethanol, methanol, isopropyl alcohol, benzyl alcohol, ethylene glycol, propylene glycol, 2-phenoxyethanol, 1,2-pentanediol, zinc pyridione, chlorobutanol, isopropylmethylphenol, nonionic surfactant Agents (polyoxyethylene lauryl ether, polyoxyethylene nonylphenyl ether, polyoxyethylene octyl phenyl ether, etc.), amphoteric surfactants, anionic surfactants (sodium lauryl sulfate, lauroyl sarcosine potassium, etc.), cationic surfactants (odor Trimethylammonium chloride, benzalkonium chloride, benzethonium chloride, methylrosaniline chloride), formaldehyde, hexamine, yellowtail Ant Green, Malachite Green, Crystal Violet, Jermal, Photosensitizer No. 101, Photosensitizer No. 201, Photosensitizer No. 401, N-long chain acyl basic amino acid derivative and its acid addition salt, zinc oxide, hinokitiol, kujin, propolis, etc. .

(29) Moisturizer Glycerin, propylene glycol, 1,3-butylene glycol, polyethylene glycol, glycerin tricaprylcaprate, glycolic acid (α-hydroxy acid),
Hyaluronic acid or its salt, chondroitin sulfate or its salt, water-soluble chitin or its derivative or chitosan derivative, pyrrolidonecarboxylic acid or its salt, sodium lactate, urea, sorbitol, amino acid or its derivative (valine, leucine, isoleucine, threonine, methionine). , Phenylalanine, tryptophan, lysine, glycine, alanine, asparagine, glutamine, serine,
Cysteine, cystine, tyrosine, proline, hydroxyproline, aspartic acid, glutamic acid, hydroxylysine, arginine, ornithine, histidine, their sulfates, phosphates, nitrates, citrates or pyrrolidonecarboxylic acid), oils and fats " Avocado oil, almond oil, fennel oil, sesame oil, olive oil, orange oil, orange lafer oil, sesame oil, cacao butter, chamomile oil, carrot oil, cucumber oil, tallow fatty acid, quince seed oil, kukui nut oil, safflower oil, shea Fat, liquid shea fat, soybean oil, camellia oil, corn oil,
Rapeseed oil, jojoba oil, persic oil, castor oil, sunflower oil, cottonseed oil, peanut oil, turtle oil, tea tree oil, mink oil, egg yolk oil, palm oil, palm kernel oil, mokurou, palm oil, eucalyptus oil, beef tallow, pork Fats, squalene, squalane, pristane or hydrogenated products of these oils (hardened oil) ", waxes (beeswax, carnauba wax, whale wax, lanolin, liquid lanolin, reduced lanolin, hard lanolin, candelilla wax, montan wax, shellac wax,
Rice wax), mineral oil (liquid paraffin, petrolatum, paraffin, ozokelide, ceresin, microcristan wax), Bacillus natto metabolite, natto extract,
Silk fiber extract, plant extract (red pine sap, aloe, kudzu root,
Chamomile, licorice, cucumber, licorice, rice or rice bran, purple root,
White birch or white birch sap, assembly, mulberry bark, biwa leaf, loofah, peony bark, peony) etc.

(30) Elastase activity inhibitor diisopropyl fluorophosphate, plant extract (salmon, Hypericum, Clara, mulberry leaf, cinnamon, ginger ginger, comfrey, salvia, elderberry, bodige, button pipi), seaweed extract and the like.

(31) Hair agent Selenium disulfide, alkylisoquinolinium bromide solution, zinc pyrithione, biphenamine, thiantol, castal tincture, ginger tincture, capsicum tincture, quinine hydrochloride, strong aqueous ammonia, potassium bromate, bromate Sodium, thioglycolic acid, etc.

(32) Antiandrogens Estrogen (estron, estradiol, ethinyl estradiol, etc.), isoflavone, oxendron, etc.

(33) Peripheral blood flow promoter Vitamin E or a derivative thereof, cucumber extract, garlic extract, ginseng extract, aloe extract, gentian extract, touki extract, cepharanthin, carpronium chloride, minoxidil and the like.

(34) Stimulants Capsicum tincture, nonyl acid vanilamide, cantharis tincture, ginger tincture, peppermint oil, l-menthol, camphor, benzyl nicotinate and the like.

(35) Metabolic activator Photosensitizer No. 301, hinokitiol, pantothenic acid or its derivatives, allantoin, placenta extract, biotin, pentadecanoic acid glyceride, etc.

(36) Antiseborrheic agent pyridoxine or its derivative, sulfur, vitamin B6
etc.

(37) Keratolytic agent Resorcin, salicylic acid, lactic acid, urea, etc.

(38) Oxidizing agent Hydrogen peroxide water, sodium persulfate, ammonium persulfate, sodium perborate, urea peroxide, sodium percarbonate, sodium peroxytripolyphosphate, sodium bromate, potassium bromate, pyroline peroxide Sodium acid salt, sodium peroxyorthophosphate, sodium silicate hydrogen peroxide adduct, sodium sulfate hydrogen peroxide adduct, sodium chloride hydrogen peroxide adduct, β-tyrosinase enzyme solution,
Mushroom extract, etc.

(39) Hair remover Strontium sulfate, sodium sulfide, barium sulfide,
Inorganic reducing agents such as calcium sulfide, thioglycolic acid or salts thereof (calcium thioglycolate, sodium thioglycolate, lithium thioglycolate, magnesium thioglycolate, strontium thioglycolate) and the like.

(40) Hair swelling agent Ethanolamine, urea, guanidine, etc.

(41) Dyeing agent 5-aminoorthocresol, 2-amino-4-nitrophenol, 2-amino-5-nitrophenol, 1-amino-4-methylaminoanthraquinone, 3,3'-iminodiphenol ,
2,4-diaminophenoxyethanol hydrochloride, 2,4-diaminophenol hydrochloride, toluene-2,5-diamine hydrochloride, nitroparaphenylenediamine hydrochloride, paraphenylenediamine hydrochloride, N-phenylparaphenylenediamine hydrochloride, metaphenylenediamine hydrochloride, ortho Aminophenol, acetic acid
N-phenylparaphenylenediamine, 1,4-diaminoanthraquinone, 2,6-diaminopyridine, 1,5-dihydroxynaphthalene, toluene-2,5-diamine, toluene-3,4-diamine, nitroparaphenylenediamine, paraamino Phenol, paranitroorthophenylenediamine, paraphenylenediamine, paramethylaminophenol, piclamic acid, sodium picramate, N, N'-bis (4-
Aminophenyl) -2,5-diamino-1,4-quinonediimine,
5- (2-hydroxyethylamino) -2-methylphenol, N-phenylparaphenylenediamine, metaaminophenol, metaphenylenediamine, 5-aminoorthocresol sulfate, 2-amino-5-nitrophenol sulfate, orthoamino sulfate Phenol, orthochloroparaphenylenediamine sulfate, 4,4'-diaminodiphenylamine sulfate, 2,4-diaminophenol sulfate, toluene-2,5-sulfate
Diamine, nitroparaphenylenediamine sulfate, paraaminophenol sulfate, paranitroorthophenylenediamine sulfate, paranitrometaphenylenediamine sulfate, paraphenylenediamine sulfate, paramethylaminophenol sulfate, metaaminophenol sulfate, metaphenylenediamine sulfate, catechol, diphenylamine , Α-naphthol, hydroquinone, pyrogallol, phloroglucin, gallic acid, resorcin, tannic acid, 2-hydroxy
-5-Nitro-2 ', 4'-diaminoazobenzene-5'-sodium sulfonate, hematein, etc.

(42) Fragrances Natural animal fragrances such as musk, civet, catrium, ambergris, anise essential oil, angelica essential oil, ylang-ylang essential oil, iris essential oil, fennel essential oil, orange essential oil, cananga essential oil, caraway essential oil, cardamom essential oil, Guayakwood essential oil, cumin essential oil, black character essential oil, cinnamon essential oil, ginnamon essential oil, geranium essential oil, copaiba balsam essential oil, coriandel essential oil, perilla essential oil, cedarwood essential oil, citronella essential oil, jasmine essential oil, ginger grass essential oil, cedar essential oil, spearmint essential oil, western Mint essential oil, large scented essential oil, tuberose essential oil, clove essential oil, orange essential oil, winter green essential oil, true balsam essential oil, butchery essential oil, rose essential oil, palmarosa essential oil, cypress essential oil, hiba essential oil,
Sandalwood Essential Oil, Petit Glen Essential Oil, Bay Essential Oil, Vetiver Essential Oil, Bergamot Essential Oil, Peruvian Balsam Essential Oil, Boad Rose Essential Oil, Homou Essential Oil, Mandarin Essential Oil, Eucalyptus Essential Oil, Lime Essential Oil, Lavender Essential Oil, Linaloe Essential Oil, Lemongrass Essential Oil, Lemon Essential Oil, Rosemary Essential Oil (Mannen wax) Essential oils, vegetable flavors such as Japanese peppermint essential oil, and other synthetic flavors.

(43) Dye / Colorant Red cabbage dye, red rice dye, madder dye, annatto dye, squid dye, turmeric dye, ende dye, krill dye, persimmon dye, caramel, gold, silver, gardenia dye, corn dye , Onion pigment, tamarind pigment, spirulina pigment, whole buckwheat pigment, cherry pigment, laver pigment, hibiscus pigment, grape juice pigment, marigold pigment, purple potato pigment, purple yam pigment, lac pigment, rutin, etc.

(44) Other hormones, sequestering agents, pH adjusting agents, chelating agents, antiseptic / antifungal agents, cooling agents, stabilizers, emulsifiers, kinetic agents
Vegetable protein and its degradation product, animal / vegetable polysaccharide and its degradation product, animal / vegetable glycoprotein and its degradation product, blood flow promoter, anti-inflammatory / anti-inflammatory / anti-allergic agent, wound healing agent, Foaming agents, thickening agents, enzymes, purified water (electronic water, small clusters, etc.), oral agents, deodorizing / deodorizing agents, bitters, seasonings, etc. are listed. An additive or synergistic improvement of the invention effect or other cosmetic effect can be expected.

The method of adding the hyaluronidase activity inhibitor of the present invention to the cosmetic composition may be added in advance or may be added during the production, and may be appropriately selected in consideration of workability. good.

[0075]

EXAMPLES Hereinafter, production examples, test examples, and prescription examples will be described, but the present invention is not limited thereto.

(Production Example 1) A 50% 1,3-butylene glycol solution was added to 100 g of grape leaves, and the mixture was dipped and filtered to obtain about 1.7 kg of an extract (dry solid content: about 0.5 to 2.5%).

(Production Example 2) Mature pericarp 1 of salamander
5 L of 50% ethanol solution is added to kg, immersed at 20 to 25 ° C for 7 days and filtered. The obtained filtrate is allowed to stand at -20 ° C for 7 days and then filtered to obtain an extract (dry solid content: about
0.5-2.0%) to obtain about 4L.

(Production Example 3) After drying the whole plant and seeds of Astragalus sinensis, the whole plant is shredded. To 1 kg, add 4 kg of 30% ethanol solution and stir at room temperature with occasional stirring.
After soaking for 12 days, filter. A mixture of absolute ethanol, 1,3-butylene glycol and purified water (15: 2
2:13) 5 kg was added and mixed, and then filtered to obtain an extract (dry solid content: about 0.5 to 2.0%) of about 7.8 kg.

(Production Example 4) 100 g of various dried plants such as grape leaf, salamander and astragalus were purified water (about 80 ° C)
At about 5 hours under heating, and filtered to obtain about 1.0 kg of extract (dry solid content: about 0.1 to 2.5%).

(Production Example 5) 100 g of various dried plants such as grape leaf, salamander and lotus root were mixed with 50% ethanol solution or 50% 1,3-butylene glycol solution or 50% propylene glycol solution, or purified water (about 30 ° C). ), Extract at room temperature for 5 days and then filter to obtain about 1.0 kg of extract (dry solid content: about 0.1 to 3.0%).

(Test 1) Hyaluronidase activity inhibition test "Test method and evaluation method" To 0.1 mL of a sample, 0.05 mL of a hyaluronidase solution (final concentration 0.4 mg / mL) was added, and the mixture was allowed to stand at 37 ° C for 2 hours.
After standing for 0 minutes, the Compound 48/80 solution (final concentration 0.1 mg
/ ML) and leave it at 37 ° C for 20 minutes, then add 0.25mL of hyaluronic acid solution (final concentration 0.4mg / mL),
It was left for 0 minutes. Next, 0.4N sodium hydroxide solution 0.1mL was added to stop the reaction, and then 0.8M potassium borate solution 0.1m was added.
L was added and heated in boiling water for 3 minutes. After cooling to room temperature, 1
After adding 3 mL of a% p-dimethylaminobenzaldehyde acetic acid solution and allowing it to stand at 37 ° C. for 20 minutes, the absorbance at 585 nm was measured. As a control, a blind test in which the enzyme was replaced with purified water was provided as the solvent of the sample, and the hyaluronidase activity inhibition rate was calculated from the following formula (Equation 1) from the difference in absorbance between the sample and the blind test.
The results are shown in Fig. 1. a. Samples Samples for the hyaluronidase activity inhibition test were various plant extracts obtained in Production Examples 1 to 3 of the present invention (solid content concentration:
It adjusted to 0.5%) and used for the test.

<Equation 1> Hyaluronidase activity inhibition rate (%) = 100-{(Sample absorbance of sample-blind absorbance of sample) / (Control sample absorbance-blind absorbance of control)} × 100

(Test Results) As shown in FIG. 1, it was confirmed that the various plant extracts of grape leaf, salamander and lotus root of the present invention had an action of significantly inhibiting hyaluronidase activity.

(Test 2) Safety test (1) Primary skin irritation test Various plant extracts obtained in Production Examples 1 to 5 were prepared with purified water so that the dry solid content concentration was about 0.5%. It was applied to the skin of Japanese white rabbits whose backs were shaved (female, 3 animals per group, weight 2.3 kg). Evaluation was carried out 24, 48, and 72 hours after application using erythema and edema as indices based on the Draize criterion. As a result, no erythema or edema was observed in any of the animals, and it was judged that there was no problem with respect to primary skin irritation.

(Test 3) Safety test (2) Skin cumulative irritation test Similarly, the various plant extracts obtained in Production Examples 1 to 5 were purified with purified water so that the concentration of dry solids was about 0.5%. Prepared and shaved back Hartley guinea pigs (female, 1 group 3)
0.5 mL for once a day, 5 times a week on the skin of an animal (body weight: around 320 g)
/ Animal was applied. Application was carried out for 2 weeks and shaving was carried out on the last application day of each week. On the day after each application day and the day after the last application day, evaluation was performed using erythema and edema as indexes based on the Draize criterion. The result is 2 for all animals.
No erythema or edema was observed over the week, and it was judged that there was no problem with cumulative skin irritation.

(Test 4) Safety test (3) Single dose toxicity test The various plant extracts obtained in Production Examples 1 to 5 were adjusted with purified water to a concentration of 12.5%, and 16 mL / mouse / kg amount,
Before the test, it was orally administered to ddy mice (male and female, 5 mice per group, 5 weeks old) that had been fasted for 4 hours, and the expression and degree of toxic symptoms were observed over time. As a result, no abnormality was observed in all mice for 14 days, and the results of autopsy were also abnormal. Therefore, the LD50 was 2,000 mg / kg or more, and it was determined to be a safe substance.

(Prescription example) Production of various cosmetic compositions In accordance with the above evaluation results, the prescription examples will be shown below. showed that. Further, the present invention is not limited to these.

[0088] (Prescription example 1) Emulsion mass%     1. Squalane 5.0     2. Olive oil 5.0     3. Jojoba oil 5.0     4. Cetyl alcohol 1.5     5. Glycerin monostearate 2.0     6. Polyoxyethylene (20) cetyl ether 3.0     7. Polyoxyethylene (20) soorbitan monooleate 2.0     8.1,3-butylene glycol 1.0     9. Glycerin 2.0    10.A: Grape leaf extract of Production Example 1       B: Salmon extract of Production Example 2       C: Astragalus sinensis extract of Production Example 3       * Any one of A to C extract 5.0    11. Preservative (paraoxybenzoate) Suitable amount    12. Perfume proper amount    13. Residue to make purified water 100

[0089] (Prescription example 2) Emulsion mass%     1. Squalane 8.0     2. Jojoba oil 7.0     3. Glyceryl p-aminobenzoate 1.0     4. Ethyl urocanate 1.0     5. Vitamin C phosphate magnesium salt 1.0     6. Cetyl alcohol 1.5     7. Glycerin monostearate 2.0     8. Polyoxyethylene (20) cetyl ether 3.0     9. Polyoxyethylene (20) soorbitan monooleate 2.0    10.1,3-butylene glycol 1.0    11. Glycerin 2.0    12.1,2-Pentanediol 3.0    13. Grape leaf extract 2.0 of Production Example 1    14. Sansho extract 2.0 of Production Example 2    15. Astragalus Radix Extract 2.0 of Production Example 3    16. Hypericum leaf or stem 70% ethanol extract 1.0    17. Purple root 50% propylene glycol extract 1.0    18. Silk protein enzymatic degradation solution 1.0    19. Pork placenta water extract 1.0    20. Antibacterial / antiseptic agent (paraoxybenzoic acid ester)    21. Residue to make purified water 100

[0090] (Prescription example 3) Cosmetic oil mass%     1. Liquid paraffin 30.0     2. Squalane 20.0     3. Olive oil 20.0     4. Isopropyl palmitate 10.0     5. Grape leaf extract from Production Example 4 3.0     6. Astragalus Radix Extract 3.0 of Production Example 4     7. Grapefruit fruit or leaf hot water extract 1.0     8. Tochu leaf hot water extract 1.0     9. Soybean seed hot water extract 1.0    10. Olive oil 1.0    11. Shea butter 1.0    12.Butyl hydroxyanisole 0.1    13. Vitamin E derivative 0.1    14. Antibacterial / antiseptic (benzalkonium chloride)    15. Perfume (Rose water) Appropriate amount    16. Residue to make purified water 100

[0091] (Formulation Example 4) Flexible lotion mass%     1. Glycerin 5.0     2.1,3-butylene glycol 5.0     3. Polyoxyethylene sorbitan monolaurate (20E.O) 1.0     4. Ethanol 15.0     5. Grape leaf 30% 1,3-butylene glycol extract 2.0     6. Bodhi flower or fruit 50% 1,3-butylene glycol extract 1.0     7. Yuzu fruit 30% ethanol extract 1.0     8. Sansho peel or fruit 30% 1,2-pentanediol extract 1.0     9. Kiwi fruit 50% ethanol extract 1.0    10. Antibacterial (lactoferrin solution)    11. Antibacterial and antiseptic (paraoxybenzoic acid ester)    12. Perfume (Western light water) Suitable amount    13. Residue to make purified water 100

[0092] (Prescription example 5) Astringent lotion mass%     1. Sorbit 2.0     2.POE (20) oleyl alcohol 1.0     3. Ethanol 15.0     4.1,2-Pentanediol 3.0     5. Sansho 30% ethanol extract 3.0     6. Astragalus 30% ethanol extract 2.0     7. Soaproot leaves 50% 1,3-butylene glycol extract 2.0     8. Gentian whole plant 50% ethanol extract 2.0     9. Hamamelis leaf or bark 50% 1,3-butylene glycol extract 1.0    10. Pepper peel or fruit 30% ethanol extract 1.0    11. Cucumber fruit 50% propylene glycol extract 1.0    12. Yeast 50% 1,3-butylene glycol extract 1.0    13. Allantoin 0.2    14. Astringent (zinc sulfocarbonate) 0.2    15. Antibacterial and antiseptic (thiamin lauryl sulfate)    16. Perfume (lavender water) Suitable amount    17. Residue to make purified water 100

[0093] (Prescription example 6) Two-layer type lotion (liquid-liquid type) mass%     1. Squalane 8.0     2.POE sorbitan tetraoleate 0.3     3. Sorbitol 1.0     4. Ethanol 15.0     5. Grape leaf 70% propylene glycol extract 3.0     6. Sansho 70% propylene glycol extract 3.0     7. Astragalus 70% propylene glycol extract 3.0     8. Oolong tea leaf or stem 70% ethanol extract 2.0     9. Red radish rhizome or root bark 50% propylene glycol extract 2.0    10. Green tea leaf or stem 50% 1,3-butylene glycol extract 2.0    11. Sage whole plant 50% ethanol extract 1.0    12. Western Bodhi flower or fruit 30% ethanol extract 1.0    13. Ascorbic acid glucoside 0.2    14. Astringent (calamine) 0.1    15. Antibacterial and antiseptic (phenoxyethanol)    16. Perfume (apple water)    17. Residue to make purified water 100

[0094] (Prescription example 7) Carmine lotion (liquid to solid) mass%     1. Glycerin 3.0     2.1,3-butylene glycol 5.0     3. Ethanol 15.0     4. Iron oxide (red iron oxide) 0.2     5. Zinc oxide 0.5     6. Kaolin 2.0     7. Grape leaf 30% propylene glycol extract 3.0     8. Astragalus 50% propylene glycol extract 3.0     9. Peony root 50% propylene glycol extract 2.0    10. Water mallow flower or leaf 50% propylene glycol extract 2.0    11. Chamomile flower 50% propylene glycol extract 2.0    12. Comfrey leaf and stem 50% ethanol extract 1.0    13. Coltsfoot flowers or leaves 50% 1,3-butylene glycol extract 1.0    14. Pig placenta enzyme decomposition solution 1.0    15. Silk protein alkaline solution 2.0    16. Camphor 0.2    17. Phenol 0.03    18. Antibacterial / antiseptic agent (photosensitive element 201 & 401)    19. Perfume (bodhi water) Suitable amount    20. Residue of purified water 100

[0095] (Prescription example 8) Pack mass%     1. Polyvinyl alcohol 15.0     2. Carboxymethyl cellulose sodium 5.0     3. Propylene glycol 3.0     4. Ethanol 10.0     5.A: Grape leaf extract of Production Example 1       B: Salmon extract of Production Example 2       C: Astragalus sinensis extract of Production Example 3       * Any one of A to C extract 3.0     6. Panax ginseng root 30% ethanol extract 1.0     7. Grape stem or leaf 30% ethanol extract 1.0     8.Wenzhou mandarin orange peel 50% 1,3-butylene glycol extract 1.0     9. Green tea leaf hot water extract 1.0    10. Peach leaf hot water extract 1.0    11. Yeast 50% 1,3-butylene glycol extract 1.0    12. Pork placenta hot water extract 1.0    13. Antibacterial and antiseptic (paraoxybenzoic acid ester)    14. Perfume (Rose water) Appropriate amount    15. Residue to make purified water 100

[0096] (Prescription example 9) Peel-off pack mass%     1. Glycerin 5.0     2. Propylene glycol 4.0     3. Polyvinyl alcohol 15.0     4. Ethanol 8.0     5. Polyoxyethylene glycol 1.0     6. Pantothenyl ethyl ether 1.0     7. Astragalus 50% 1,3-butylene glycol extract 3.0     8. Grape leaf 50% glycerin extract 2.0     9. Safflower whole plant 50% ethanol extract 1.0    10. Dutch jelly (parsley) leaf or stem 50% ethanol extract 1.0    11. Eucalyptus leaf or stem 30% ethanol extract 1.0    12. Royal jelly 50% ethanol extract 1.0    13. Trehalose solution 1.0    14. Antibacterial and antiseptic (paraoxybenzoic acid ester)    15. Perfume (Chamomile water) Suitable amount    16. Residue to make purified water 100

[0097] (Prescription example 10) Cold cream mass%     1. White beeswax 11.0     2. Liquid paraffin 22.0     3. Lanolin 10.0     4. Olive oil 5.0     5. Chamomile oil 5.0     6. Palm oil 5.0     7. Borax 0.5     8.A: Grape leaf extract of Production Example 1       B: Salmon extract of Production Example 2       C: Astragalus sinensis extract of Production Example 3       * Any one of A to C extract 5.0     9. Achillea millefolium extract 2.0       (Ethanol: 1,3-butylene glycol = 1: 1 extraction solvent)    10. White birch bark extract 2.0       (Ethanol: 1,3-butylene glycol = 1: 1 extraction solvent)    11. Ginseng root 50% propylene glycol extract 2.0    12. Matsuhodo sclerotium 50% 1,2-butylene glycol extract 1.0    13. Soybean seed water extract 1.0    14. Yeast 50% 1,3-butylene glycol extract 2.0    15. Liquid shea fat 1.0    16. Dipotassium glycyrrhizinate 0.1    17. Antibacterial and antiseptic (acrinol) 0.1    18. Perfume (Ylang-Ylang water) Suitable amount    19. Residue to make purified water 100

[0098] (Formulation example 11) Emollient cream mass%     1. Stearic acid 2.0     2. Stearyl alcohol 7.0     3. Reduced lanolin 2.0     4. Squalane 5.0     5. Octyldodecanol 6.0     6. Polyoxyethylene cetyl ether (25E.O.) 3.0     7. Lipophilic glyceryl monostearate 2.0     8. Propylene glycol 2.0     9.1,2-Pentanediol 2.0    10. Sansho 50% propylene glycol extract 2.0    11. Astragalus 50% dipropylene glycol extract 2.0    12. Shiso leaf 50% propylene glycol extract 2.0    13. Purple root 50% propylene glycol extract 2.0    14. Soybean seed fermented soybeans 1.0    15. Glycyrrhetinic acid 0.1    16. Pig placenta enzyme decomposition solution 1.0    17. Antibacterial (lactoferrin solution) 0.5    18. Antibacterial and antiseptic (Zinc pyridione)    19. Perfume (Mugwort water) Suitable amount    20. Residue of purified water 100

[0099] (Prescription example 12) Face wash cream Mass%     1. Myristic acid 25.0     2. Stearic acid 5.0     3. Beef tallow fatty acid 5.0     4. Propylene glycol 10.0     5. Potassium hydroxide 6.0     6. Coconut oil fatty acid diethanolamide 6.0     7. Grape leaf extract 2.0 of Production Example 1     8. Sansho extract 2.0 of Production Example 2     9. Astragalus Radix Extract 2.0 of Production Example 3    10. Apple fruit 20% 1,3-butylene glycol extract 1.0    11. Rosehip fruit 30% ethanol extract 1.0    12.Kakkon hot water extract 1.0    13. Burdock root 50% 1,3-butylene glycol extract 1.0    14. Glycyrrhizic acid 1.0    15. Apricot kernel 0.1    16. Walnut shell grain 0.1    17. Antibacterial and antiseptic (2-phenoxyethanol) 0.1    18. Perfume (tokimizu) Appropriate amount    19. Residue to make purified water 100

[0100] (Prescription example 13) Face-wash cream mass%     1. Stearic acid 10.0     2. Palmitic acid 10.0     3. Myristic acid 12.0     4. Lauric acid 4.0     5. Glycerin 18.0     6. Sodium dl-pyrrolidonecarboxylate 1.0     7. Dioctyl adipate 1.0     8. Cetostearyl alcohol 3.0     9. Triethanolamine 3.0    10. Ergocalciferol 1.0    11. Oleyl alcohol 1.5    12. Lanolin derivative (EO adduct) 1.0    13. Potassium hydroxide 6.0    14.A: Grape leaf extract of Production Example 1       B: Salmon extract of Production Example 2       C: Astragalus sinensis extract of Production Example 3       * Any one of A to C extract 3.0    15. Royal Jelly Extract 1.0       (Ethanol: 1,3-butylene glycol = 1: 1 extract)    16. Oil-soluble chamomile flower or leaf extract 1.0       (Ethanol: 1,3-butylene glycol = 1: 1 extract)    17. Oil-soluble licorice root or rhizome extract 1.0       (Ethanol: 1,3-butylene glycol = 1: 1 extract)    18. Edetate 1.0    19. Glycyrrhetinic acid 1.0    20. Corn cob grain 0.1    21. Walnut shell grain 0.1    22. Antibacterial / antiseptic agent (photosensitive element 401) 0.1    23. Perfume (Mugwort water)    24. Residue to make purified water 100

[0101] (Prescription example 14) Body soap mass%     1. Potassium laurate 15.0     2. Potassium myristate 5.0     3. Propylene glycol 5.0     4. Alkanediol 1.0     5. Astragalus Radix Extract 4.0 of Production Example 3     6. Seaweed and kelp 70% 1,3-butylene glycol extract 0.5     7. Armchair leaf or stem 70% 1,3-butylene glycol extract 0.5     8. Soybean seed fermented natto fermentation liquid 0.5     9. Loquat leaf 50% dipropylene glycol extract 0.5    10. Mackerel crape myrtle leaf 20% 2,3-butylene glycol extract 0.5    11. Aloe pulp end 1.0    12. Polyethylene powder 0.5    13. Hydroxypropyl chitosan solution 0.5    14. Amino acids (arginine, glycine, glutamine, etc.) 0.5    15. Monoammonium glycyrrhizinate 0.1    16. Antibacterial / antiseptic (undecylenic acid, phenol)    17. pH adjuster    18. Perfume (lavender water) Suitable amount    19. Residue to make purified water 100

[0102] (Prescription example 15) Body soap mass%     1. Potassium laurate 15.0     2. Potassium myristate 5.0     3. Propylene glycol 5.0     4. Sansho Extract 3.0 of Production Example 2     5. Astragalus Radix Extract 3.0 of Production Example 3     6. Toki rhizome 70% 2,3-butylene glycol extract 0.5     7.Kakkon 70% 1,3-butylene glycol extract 0.5     8. Chlorella 70% 1,3-butylene glycol extract 0.5     9. Hydrolyzed collagen solution derived from fish (salmon or flounder) 0.5    10. Psyllium whole plant 50% ethanol extract 0.5    11. Amino acids (glutamine, proline, lysine, etc.) 0.5    12. Monoammonium glycyrrhizinate 0.1    13. Antibacterial and antiseptic (undecylenic acid, phenoxyethanol)    14. pH adjusting agent    15. Perfume (orange water)    16. Residue to make purified water 100

[0103] (Prescription example 16) Sunscreen cosmetics (O / W type) Mass%     1. Oxybenzone 2.0     2. Octyl para methoxycinnamate 5.0     3.Dihydroxymethoxybenzophenone 0.2     4. Squalane 10.0     5. Vaseline 5.0     6. Stearyl alcohol 3.0     7. Stearic acid 3.0     8. Glyceryl monostearate 2.0     9. Polyethyl acrylate 1.0    10.1,3-butylene glycol 6.0    11. Disodium edetate 0.1    12. Triethanolamine 1.0    13. Titanium dioxide 5.0    14. Grape leaf 50% ethanol extract 3.0    15. Astragalus 50% ethanol extract 1.0    16. White birch bark 70% dipropylene glycol extract 1.0    17. Cornflower leaf 50% propylene glycol extract 0.5    18.Kakkon 50% propylene glycol extract 0.5    19. Yuzu fruit 50% dipropylene glycol extract 0.5    20. Antibacterial and antiseptic (benzyl paraoxybenzoate)    21. Fragrance (jasmine water) Suitable amount    22. Residue of purified water 100

[0104] (Prescription example 17) Sunscreen cosmetics (oil type) Mass%     1. Liquid paraffin 70.0     2. Tetrahydroxybenzophenone 1.0     3. Cetyl octanoate 19.8     4.A: Grape leaf extract of Production Example 1       B: Salmon extract of Production Example 2       C: Astragalus sinensis extract of Production Example 3       * Any one of A to C extract 5.0     5. Chamomile flowers 10% 1,3-butylene glycol extract 1.0     6. Horse chestnut whole plant 30% 1,3-butylene glycol extract 0.5     7. Mallow flower or leaf 50% propyl alcohol extract 0.5     8. All the coix seeds 50% 1,3-butylene glycol extract 0.5     9. Meliroth flower or leaf 70% 1,3-butylene glycol extract 0.5    10.Ethyl paraaminobenzoate 0.2    11. Antioxidant (Butyl hydroxytoluene) Suitable amount    12. Perfume (Mixed perfume)

[0105] (Prescription example 18) Cream foundation (O / W type) Mass%     1. Stearic acid 4.0     2. Glycerin monostearate 3.0     3. Cetanol 1.5     4.Isopropyl myristate 7.0     5. Liquid paraffin 10.0     6. White beeswax 3.0     7. Triethanolamine 1.5     8. Glycerin 3.0     9. Bentonite 1.0    10.Titanium oxide 8.0    11.2,4-Dihydroxybenzophenone 8.0    12. Kaolin 3.0    13. Talc 3.0    14. Coloring pigment (yellow iron oxide) 1.0    15. Grape leaf 70% 1,3-butylene glycol extract 1.0    16. Astragalus 70% 1,2-Pentanediol extract 1.0    17. Dokudami leaf hot water extract dry powder 0.3    18. Yukinoshita whole plant hot water extract dry powder 0.3    19. Rhizophora rhizome or root bark 50% ethanol extract 0.3    20. Antibacterial and antiseptic (phenoxyethanol) 0.1    21. Perfume (Rose water) Suitable amount    22. Residue of purified water 100

[0106] (Prescription example 19) Shampoo mass%     1. Lauryl sulfate triethanolamine 5.0     2. Sodium polyoxyethylene lauryl ether sulfate 12.0     3.1,3-butylene glycol 4.0     4. Lauric acid diethanolamide 2.0     5. Disodium edetate 0.1     6.A: Grape leaf extract of Production Example 1       B: Salmon extract of Production Example 2       C: Astragalus sinensis extract of Production Example 3       * Any one of A to C extract 3.0     7. Mackerel clover 20% 2,3-butylene glycol extract 2.0     8. Hot water extract of root bark or rhizome 2.0     9. Iris flowers or rhizome 30% 1,4-butylene glycol extract 2.0    10. Toki root 30% 1,4-butylene glycol extract 2.0    11. Hot water extract of tomato fruit 1.0    12. Hydroxypropyl chitosan solution 1.0    13. Hyaluronic acid solution 1.0    14. Dipotassium glycyrrhizinate 0.1    15. Antibacterial and antiseptic (photosensitive element 101)    16. pH adjuster    17. Perfume (sandalwood water)    18. Residue to make purified water 100

[0107] (Prescription example 20) Rinse mass%     1. Stearyl trimethyl ammonium chloride 3.0     2. cetostearyl alcohol 3.0     3. Polyoxyethylene lanolin ether 3.0     4. Propylene glycol 5.0     5.1,2-Pentanediol 2.0     6. Astragalus 50% 1,2-pentanediol extract 3.0     7. Grape leaf 50% 2,3-butylene glycol extract 3.0     8. Clove whole plant 50% 1,2-pentanediol extract 1.0     9. Scented flower 50% 1,3-butylene glycol extract 1.0    10. Mackerel fruit 30% 1,2-butylene glycol extract 1.0    11. Yellow rhizome 50% 1,3-butylene glycol extract 1.0    12. Comfrey leaf or stem 50% 1,3-butylene glycol extract 1.0    13. Soybean seed fermented soybeans 0.5    14. Hydroxyethyl chitosan solution 0.5    15. Hydrolyzed collagen solution derived from fish (salmon or tuna) 0.5    16. Trehalose solution 0.5    17. Hydrolyzed silk solution 0.5    18. Antibacterial / antiseptic (benzalkonium chloride)    19. Fragrance (grape water) Suitable amount    20. Residue of purified water 100

[0108] (Prescription example 21) Rinse mass%     1. Stearyl trimethyl ammonium chloride 2.0     2. cetostearyl alcohol 2.0     3. Polyoxyethylene lanolin ether 3.0     4. Propylene glycol 5.0     5. Ethylene glycol 3.0     6. Sansho extract of Production Example 2 3.0     7. Astragalus Radix Extract 3.0 of Production Example 3     8. Soaproot leaves 50% 1,3-butylene glycol extract 1.0     9. Western Bodhi flower or fruit 50% 1,4-butylene glycol extract 1.0    10. Olive leaf 50% 1,2-butylene glycol extract 1.0    11. Sharon fruit or flower 50% 1,3-butylene glycol extract 1.0    12. Amakusa whole grass 50% glycerin extract 1.0    13. Bifidobacterium fermentation liquid 1.0    14. Sodium alginate 1.0    15. Trehalose solution 1.0    16. Hydrolyzed keratin solution 1.0    17. Antibacterial and antiseptic (benzalkonium chloride)    18. Perfume (Chamomile water) Suitable amount    19. Residue to make purified water 100

[0109] (Formulation Example 22) Hair liquid mass%     1. Ethanol 29.0     2. Polyoxypropylene butyl ether phosphoric acid 10.0     3. Polyoxypropylene monobutyl ether 5.0     4. Triethanolamine 1.0     5. Sunsho 30% 1,3-butylene glycol extract 3.0     6. Apricot fruit 50% glycerin extract 1.0     7. Hop female spike 50% ethanol extract 1.0     8. Melissa whole plant 50% ethanol extract 1.0     9. Usubasaicin rhizome 30% ethanol extract 1.0    10. White birch sap 1.0    11. Carpronium chloride 0.3    12. Hinokitiol 0.5    13. Keratin decomposition solution 0.5    14. Stearyl glycyrrhetinate 0.1    15. Antibacterial and antiseptic (paraben, benzalkonium chloride) appropriate amount    16. Perfume (Rosehip water) Suitable amount    17. Residue to make purified water 100

[0110] (Formulation Example 23) Hair liquid mass%     1. Ethanol 29.0     2. Polyoxypropylene butyl ether phosphoric acid 10.0     3. Polyoxypropylene monobutyl ether 5.0     4. Triethanolamine 1.0     5.1,2-hexanediol 1.0     6. Grape leaf 50% ethanol extract 3.0     7. Astragalus 50% 1,3-butylene glycol extract 3.0     8. Assembly leaf or stem 50% 1,2-butylene glycol extract 1.0     9. Ginseng root hot water extract 1.0    10. Apple fruit 30% ethanol extract 1.0    11. Sesamorin 0.3    12. Azulene 1.0    13. Antibacterial / antiseptic (paraben, benzalkonium chloride) appropriate amount    14. Perfume (orange water) Suitable amount    15. Residue to make purified water 100

[0111] (Formulation Example 24) Hair liquid mass%     1.Ethanol 40.0     2. Ethyl oleate 1.0     3. Polyoxyethylene (40) hydrogenated castor oil 2.0     4.A: Grape leaf extract of Production Example 1       B: Salmon extract of Production Example 2       C: Astragalus sinensis extract of Production Example 3       * Any one of A to C extract 5.0     5. Comfrey leaf or stem 50% ethanol extract 1.0     6. Yuzu fruit or leaf 50% ethanol extract 1.0     7. Soybean seed natto fermented liquid 1.0     8. Hamamelis leaf or stem hot water extract 1.0     9. Comfrey leaf or stem 50% ethanol extract 1.0    10. Lettuce leaf 50% ethanol extract 1.0    11. Carpronium chloride 0.3    12. Pantethine solution 0.3    13. Amino acids or their derivatives 3.0     (Lysine, alanine, pyrrolidone carboxylic acid, etc.)    14. Antibacterial and antiseptic (paraben, benzalkonium chloride) appropriate amount    15. Perfume (Rose water) Appropriate amount    16. Residue to make purified water 100

[0112] (Prescription example 25) Heartonic mass%     1.Ethanol 40.0     2. Ethyl oleate 1.0     3. Polyoxyethylene (40) hydrogenated castor oil 2.0     4. Grape leaf 30% ethanol extract 3.0     5. Astragalus 30% ethanol extract 1.0     6. Antibacterial / antiseptic (propyl paraoxybenzoate) 0.2     7. Residue to make purified water 100

[0113] (Prescription example 26) Heartonic mass%     1.l-menthol 0.2     2. Ethanol 32.5     3. Polyoxyethylene hydrogenated castor oil 0.5     4. Propylene glycol 5.0     5. Diphenhydramine hydrochloride 0.3     6.A: Grape leaf extract of Production Example 1       B: Salmon extract of Production Example 2       C: Astragalus sinensis extract of Production Example 3       * Any one of A to C extract 5.0     7. Hypericum perforatum fruit or pericarp hot water extract 1.0     8. Western Bodhi flower or leaf 50% propylene glycol extract 1.0     9. Lavender flower or flower spike hot water extract 1.0    10. Bildo Aoi rhizome or root bark 50% ethanol extract 1.0    11. Auregon rhizome or root bark 50% ethanol extract 1.0    12. Soybean seed hot water extract 1.0    13. Carboxymethyl chitin solution 1.0    14. Chicken comb extract solution 0.2    15. Pantethine solution 0.2    16. Antibacterial / antiseptic (phenoxyethanol)    17. Perfume (Rose water) Suitable amount    18. Residue to make purified water 100

[0114] (Prescription example 27) Hair growth and hair nourishing agent% by mass     1.Ethanol 60.0     2. Pepper 50% glycerin extract 5.0     3. Astragalus 50% propylene glycol extract 2.0     4. Vitamin E derivative 0.5     5. Capsicum tincture 0.5     6. Resorcin 0.5     7.Dipotassium glycyrrhizinate 0.5     8. Carboxymethyl chitin solution 0.5     9. Collagen protein enzymatic degradation solution 1.0    10. Pig hematin solution 0.5    11. Pork mucin solution 0.5    12. Amino acids (arginine, glycine, glutamine, etc.) 0.5    13. Antibacterial and antiseptic (paraben) 0.1    14. Perfume (rosemary water) Suitable amount    15. Residue to make purified water 100

[0115] (Prescription example 28) Hair growth and hair nourishing agent% by mass     1.Ethanol 60.0     2.A: Grape leaf extract of Production Example 1       B: Salmon extract of Production Example 2       C: Astragalus sinensis extract of Production Example 3       * Any one of A to C extract 3.0     3. Hot water extract of rhizome root bark or rhizome 3.0     4. Whole plant 60% ethanol extract 3.0     5. Peony rhizome or root bark 60% ethanol extract 3.0     6. Artemisia leaf or stem 50% 1,3-butylene glycol extract 1.0     7. Soybean seed natto fermented liquid 1.0     8. Whole clover 20% 2,3-butylene glycol extract 1.0     9. Pepper fruit hot water extract 1.0    10. Cantharis tincture 0.5    11. Pantothenic acid derivative 0.2    12.β-glycyrrhetinic acid 0.2    13. Resorcin 0.2    14. Hydroxyethyl chitosan solution 0.2    15. Elastin hydrolyzate 0.2    16.Keratin protein enzymatic degradation solution 0.2    17. Preservative (paraben) 0.1    18. Perfume (Bergamot water) Suitable amount    19. Residue to make purified water 100

[0116] (Prescription example 29) Granule bath agent mass%     1. Sodium hydrogen carbonate 58.0     2. Anhydrous sodium sulfate 30.0     3. Borax 5.0     4.A: Grape leaf extract of Production Example 1       B: Salmon extract of Production Example 2       C: Astragalus sinensis extract of Production Example 3       * Any one of A to C extract 3.0     5. Sorbitol 1.0     6. Peach leaf 70% ethanol extract dry powder 1.0     7. Black tea leaf 30% ethanol extract dry powder 1.0     8. Dye (Gunjo green)

[0117] (Formulation example 30) Granule bath agent mass%     1. Sodium hydrogen carbonate 58.0     2. Anhydrous sodium sulfate 30.0     3. Borax 3.0     4. Hyaluronic acid powder 3.0     5. Grape leaf hot water extract dry powder 1.0     6. Sansho hot water extract dry powder 1.0     7. Astragalus hot water extract dry powder 1.0     8. Orange peel 50% ethanol extract 1.0     9. Apple juice powder 1.0    10. Dye (Gunjou, chromium hydroxide)    11. Perfume (grape water) Suitable amount

(Formulation Example 31) Coating protectant Gauze or liniment cloth with grape leaf or salamander or Astragalus root hot water extract, antibiotics, anti-inflammatory agents, etc.
An appropriate amount of the mixed formulation solution is impregnated and attached to the wound.
Alternatively, the hot water extract of rubus rhizome or loquat leaves or whole lotus roots may be directly sprayed locally and covered with gauze or the like.

[0119] (Prescription example 32) Toothpaste mass%     1. Silicic anhydride 20.0     2.Sorbit solution 50.0     3. Glycerin 10.0     4. Grape leaf hot water extract 5.0     5. Astragalus hot water extract 5.0     6. Sodium lauryl sulfate 2.0     7. Saccharin sodium 0.05     8. Sodium carboxymethyl cellulose 1.5     9. Fragrance (cardamom water)    10. Appropriate amount of colorant    11. Purified water

[0120] (Prescription example 33) Oral cooling agent Mass%     1. Ethanol 20.0     2. Glycerin 15.0     3. Polyoxyethylene hydrogenated castor oil 1.0     4. Saccharin 0.2     5.Chlorhexidine 0.01     6.A: Grape leaf hot water extract       B: Sansho hot water extract       C: Astragalus hot water extract       * Any one of A to C extract 3.0     7. Hypericum leaf or stem hot water extract 1.0     8. Grapefruit fruit or leaf hot water extract 1.0     9. Green tea leaf hot water extract dry powder 0.1    10. Dye (Gunzhou Green) Appropriate amount    11. Residue to make purified water 100

[0121] (Prescription example 34) Dish detergent for mass%     1. Alkyl (C12) glucoside 20.0     2. Polyoxyethylene (3) dodecyl ether sulfate Na 10.0     3. Glycerin 2.0     4. Ethanol 5.0     5. Sansho hot water extract 3.0     6. Hot water extract of dried root bark of Hyogi 1.5     7. Sandalwood whole plant 50% dipropylene glycol extract 0.5     8. Residue to make purified water 100

(Test 5) Use effect test The effect of actually using the cosmetic composition of the present invention was examined. Use test is for healthy adult women 25 ~
30 people each 50 years old will be panelists, and there will be 2 daily mornings and evenings.
After washing the face and washing the face, an appropriate amount of the emulsion of Formulation Example 1 was applied to the face for 3 months. As a control, an emulsion prepared by removing various plant extracts of the present invention and formulated by the same method was used. The evaluation method was carried out according to the following criteria, and the results are shown in Tables 1 and 2 and the numerical values in the tables represent the number of people. No one complained of skin abnormality during the period of use.

[Effect of improving skin tension and gloss] Effective: Increased skin tension and gloss. Slightly effective: Skin tension and luster slightly increased. Ineffective: No change from before use.

[0124]

[Effect of Wrinkle / Talmi Improvement of Skin] Effective: Wrinkle Talumi is less noticeable. Slightly effective: Wrinkle Talmi is slightly less noticeable. Ineffective: No change from before use.

[0126]

(Test Results) As shown in Tables 1 and 2, the emulsion containing various plant extracts of grape leaf, salamander and lotus root of the present invention significantly gives the skin firmness and luster.
It was also confirmed that wrinkles and tarmi on the skin were reduced.

(Test 6) Use effect test The effect of actually using the cosmetic composition of the present invention was examined. The usage test was conducted by 30 people aged 30 to 50 years old who suffer from eczema, itchiness, and rough skin, and apply the appropriate amount of the emulsion of Prescription Example 1 to the face for 3 months after washing twice daily in the morning and at night. It was done by doing. As a control, an emulsion prepared by removing various plant extracts of the present invention and formulated by the same method was used. In addition, the evaluation method was performed according to the following criteria, and the results are shown in Table 2, and the numerical values in the table represent the number of people. No one complained of skin abnormality during the period of use.

"Eczema, rough skin improving effect" Effective: Eczema, itchiness, and rough skin were improved. Slightly effective: Eczema, itchiness and rough skin were slightly improved. Ineffective: No change from before use.

[0130]

(Test Results) As shown in Table 3, it was confirmed that the emulsion containing various plant extracts of grape leaf, salamander and lotus root of the present invention improves eczema, itchiness and rough skin.

[0132]

EFFECT OF THE INVENTION Grape leaf, salamander of the present invention,
One or more kinds of plant extracts selected from astragalus have a hyaluronidase activity inhibitory action, and a cosmetic composition containing these improves tension, luster, wrinkles and tarmi on the skin. In addition, inflammatory skin diseases (eg, eczema, pruritus, rough skin) can be improved. Therefore, it is effective for preventing skin aging or skin inflammation and can be applied to preparations in any form (medicines, quasi drugs, cosmetics). It can also be used for other general foods and drinks.

[Brief description of drawings]

FIG. 1 is a graph showing the hyaluronidase activity inhibitory rate of various plant extracts of grape leaf, salamander and lotus root of the present invention.

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Claims (2)

[Claims] 1. A hyaluronidase activity inhibitor comprising one or more plant extracts selected from grape leaf, salamander and lotus root. 2. A cosmetic composition comprising the hyaluronidase activity inhibitor according to claim 1.