JPH0873314A - External preparation for skin and bathing agent - Google Patents

Abstract

PURPOSE: To obtain an external preparation for skin or a bathing agent showing synergistic effects of preventing and improving allergic skin inflammation diseases, chopped skin and dryness of skin and suppressing aging of skin, by using extracted components of specific plants. CONSTITUTION: This external preparation for skin or a bathing agent is obtained by using an extracted component prepared by extracting leaves of Eriobotrya japonica Lindley with water, ethanol, 1,3-butylene glycol or a mixed solution of two or more of them and extracted components made by similarly extracting Paeonia suffruticosa Andrews and Zanthoylum piperitum De Candolle as essential components. One or more similar extracted substances selected from Paeonia suffruticosa Andrews and Perilla frutescens, Houttuynia cordata and Mentha piperita L. may be used together. The external preparation for skin or the bathing agent prevents and improves skin inflammation diseases such as flare, humid tetter, edema, boil and atopic dermatitis and troubles of skin such as chopped skin and dryness of skin. The external preparation for skin or the bathing agent can make skin texture and keep the skin healthy.

Description

Detailed Description of the Invention

The present invention relates to an allergic skin inflammatory disease,
The present invention relates to a highly safe external preparation for external use or a bath preparation which is effective in preventing and improving rough skin and dryness of the skin, and preventing aging of the skin. More specifically, the present invention provides a safe external preparation for skin or bath which exerts a synergistic effect on various efficacy of the title by using an extract component of a specific plant together.

[0002]

[Field of Industrial Application] The external preparation for skin or bath agent in the present invention means allergic skin inflammatory diseases (eg, redness, eczema, edema, swelling, atopic dermatitis, etc.), and skin such as rough skin and dry skin. It means all external preparations for the purpose of preventing or improving the above troubles. Specifically, liquids, emulsions, creams, ointments, gels, powders, granules, solids, or foams, 1) external medicines, 2) external quasi drugs, 3) topical Or skin cosmetics for the whole body, 4) medicinal and / or cosmetic preparations applied to the scalp / hair (for example, shampoos, rinses, treatments, permanent liquids, hair dressings,
Hair artic agents, hair growth and hair nourishing agents, etc.) 5) Bath agents that are used by throwing them in a bath.

[0003]

2. Description of the Related Art A living body has an immune function to protect itself by eliminating foreign substances such as pathogenic microorganisms. However, this function sometimes acts to injure the body and causes various diseases. This disorder reaction due to the immune function is particularly called an allergic reaction, and is classified into two groups of immediate type allergy and delayed type allergy according to the time from the reaction to the onset. Further, allergies are classified into four types I to IV according to the mechanism of their onset.

Type I is the most frequently occurring type of allergy and is a reaction mainly involving immunoglobulin E (IgE) antibodies. This IgE is produced against the allergen invading the body and has a strong effector action on mast cells and basophils. Mast cells and basophils (a type of white blood cell) are cells that have granules containing pharmacologically active amines such as histamine and serotonin, the former being present in the vicinity of blood vessels and connective tissue, and the latter in blood. Receptors that bind IgE antibodies are present on these cell membranes and have the property of strongly binding to IgE antibodies. When the allergen of the same species binds again to the IgE antibody bound to mast cells or basophils, many active substances such as histamine described above are released from these cells with degranulation, which causes various allergic symptoms.
Symptoms such as itchy redness or blistering rash (urticaria) on the skin, itching caused by inflammation of the nose and eyes, and nasal discharge and tears are active, or respiratory distress due to clogged trachea Symptoms causing bouts of asthma (bronchial asthma) are classified as allergic diseases of this type.

[0005] In the type I allergy, the process can be roughly divided into three stages, and each stage is classified according to each action point, and attempts to prevent, alleviate or treat allergic diseases by drug administration are made. I've been told. That is,
When a foreign antigen invades the body, IgE antibody is produced by the immunocompetent cell system, and the IgE antibody is distributed in the respiratory tract, the skin, the digestive organs, and the mast cells that are distributed in the common sites of allergic reaction,
Alternatively, sensitization is established by sticking to basophils in the blood. This is the reaction called the first stage. Next, when the antigen again contacts the sensitized cells, the cells form vacuoles, swell,
It causes morphological changes such as degranulation and releases chemical mediators called histamine, serotonin, SRS-A and the like. This is the second stage reaction. The released chemical transmitter acts on contraction of smooth muscles such as bronchial muscle and digestive tract, enhancement of capillary permeability, migration of neutrophils, aggregation of platelets, etc., resulting in asthma, low back pain and diarrhea. The process of developing allergic symptoms such as digestive allergies, nasal allergies, and urticaria is the third stage reaction.
Therefore, in a narrow sense, drugs acting in the first and second stages can be regarded as preventive drugs against allergic reaction, and drugs acting in the third stage can be regarded as symptomatic therapeutic drugs. Currently, the most active research on antiallergic agents is the development of drugs that suppress this second stage.

Type II allergy is known as a disorder reaction caused by destruction of tissue cells by IgG and IgM antibodies.
IgG and IgM antibodies that act on this system are antibodies that have the property (effector action) of significantly activating the complement system when bound to an antigen. The reaction mechanism is that IgG or IgM antibody binds to an antigen cell such as a microorganism, thereby activating the complement system and destroying the target cell. The function of the complement system is to activate the protease system on target cells in a chained manner to form and destroy the membrane disorder complex (MAC), and also to generate a group of fragments called anaphylatoxins, which induce mast cell It promotes the treatment of foreign substances through a complex process such as promoting the release of histamine from erythrocytes and attracting polymorphonuclear leukocytes and macrophages. However, such reactions may be caused by virus-infected autologous cells, or tissue cells or erythrocytes that are bound or adhered by haptens (substances that are not antigenic in themselves but produce antibodies when bound to proteins, etc.) and bacteria, as well as autologous cells. In an immune disease, the living body recognizes these cells as antigen cells and causes them, even if they are in their normal cells. Typical examples of type II allergic diseases include aplastic anemia and hemolytic anemia.

[0007] Type III allergy is a reaction in which a large amount of an antigen-antibody conjugate produced by binding an antibody to an antigen is deposited on tissues and damaged. Antibodies involved in this reaction are mainly IgG antibodies, which are reactions involving many factors such as the complement system and polymorphonuclear leukocytes like type II, but the difference from type II is that the antigen is not a cell but a substance. Can be said to be a major feature. The reaction mechanism is that the produced antigen-antibody conjugates are blood vessels, kidneys, joints,
It is deposited on tissues such as skin and activates the complement system (effector function). As a result, a large amount of anaphylatoxin is produced, which promotes vascular permeability increase, smooth muscle contraction, and histamine release from mast cells to cause inflammation. In addition, the action of phagocytic cells such as polymorphonuclear leukocytes accumulated by the action of anaphylatoxin causes a lysosomal degranulation reaction of cells, and various kinds of degrading enzymes such as proteases in lysosomes are released to the outside. Tissues and cells are damaged, and allergic inflammatory reaction is enhanced. The effect of released enzymes is not the only factor that causes damage to tissues and cells by the action of phagocytic cells. That is, the action of excess active oxygen produced by promoting respiration with phagocytosis is also emphasized. It has been pointed out that excess reactive oxygen causes adverse effects on the living body such as damage to normal tissue cells, pigmentation, and cell aging.

In Type I to III type allergies, a disorder reaction occurs in a relatively short time (a reaction appears in about 2 to 3 minutes, and the reaction strength reaches its maximum in about 10 minutes) after contact with an antigen. Although it is called immediate type allergy because it appears, the reaction classified as type IV finally begins to show a disorder reaction several hours after reacting with the antigen, and then the reaction slowly progresses and the maximum strength is reached. It takes 24 to 48 hours to reach the target, so it is called delayed-type allergy. A characteristic of type IV allergy is that lymphocytes called T cells are involved instead of the antigens found in the immediate type. That is, T sensitized by the antigen
When cells are activated by antigen again, various inflammatory factors called lymphokines (macrophage chemotactic factor, lymphocyte migration factor, macrophage activating factor,
Vascular permeability factor, etc.), and these are thought to induce and amplify the reaction. Contact skin dermatitis, which is characterized by redness, swelling, induration, and local infiltration of mononuclear cells, is well known as a skin reaction in delayed-type allergy.

[0009] Various test methods have been proposed according to the allergic reaction types classified in this way, and until now, approaches to factors effective in the prevention or amelioration of allergic diseases have been actively pursued. For example, for type I allergy, there are antispasmodics that relax smooth muscles, sympathomimetics that suppress hyperactivity of capillaries, and antihistamines. All of these are drugs that act in the third stage and are effective as symptomatic therapeutic agents, but most of them are synthetic drugs and have a problem of side effects. Further, active research has been conducted on the development of drugs effective against type II and type III allergies, but the current situation is that no specific antiallergic agent has been found yet.

[0010]

SUMMARY OF THE INVENTION In view of these circumstances,
The present inventors have allergic inflammatory diseases (particularly types I to III)
The research was started by searching for natural ingredients with less side effects and irritation as effective factors for the prevention or amelioration of. As a result, we found some factors that are thought to be effective for some plant components, and then
As a result of using them in various combinations, it was found that the combined use of certain specific plant components shows a synergistic increase in the desired effect. By applying it as an external preparation for the skin, not only the prevention or improvement of allergic diseases but also the prevention and improvement of rough skin, the softening of the skin quality and the smoothening of the skin texture (improvement of the skin quality itself) The present invention has been completed, knowing that it is also effective in such cases.

[0011]

That is, the intended effect of the above can be achieved by the following three types of external preparations for skin which are formulated by combining specific plant components. (1) A skin external preparation containing, as an essential component, an extract component of loquat leaf and at least one kind of extract component selected from sea peony or salamander. (2) As an essential component, any one selected from the extract component of Botanpi and at least one of perilla, Dokudami, and peppermint
An external preparation for the skin containing the extracted components of seeds. (3) A skin external preparation containing, as an essential component, an extract component of Dokudami and at least an extract component of mint. Hereinafter, the present invention will be described in more detail.

The "loquat leaf" used in the present invention means loquat (Rosaceae) plant loquat (Eriobotrya japonica Lindle).
y) leaves. In addition, "button pie" means button department (Paeon
iaceae) The root bark of the plant button (Paeonia suffruticosa Andrews), and "sansho" means the Rutaceae plant Zanthoxylum piperitum De Candoll.
e) or other mature fruit of the same genus plant, "Perilla frutescens" means the Labiatae plant Perilla frutescens Br
itton var.acuta Kudo) or its related plants (Labiatae)
The leaves and branch tips, "Dokudami", means
(ceae) The above-ground part or whole plant of the plant Houttuynia cordata Thunberg.
(iatae) Plant Leaf of Mentha piperita L. is used.

As the solvent for extracting the active ingredient from these plants, any one kind selected from water, ethanol and 1,3-butylene glycol can be used, or two or more kinds can be arbitrarily combined and used. The obtained extract may be optionally dried, concentrated, diluted or the like depending on the form of the applied external preparation for skin. Manufacturing examples are shown below.

[0014]

EXAMPLES Production Example 1 100 g of loquat leaf was added to 1,000 mL of a 30% ethanol (EtOH) solution,
Or 50% 1,3-butylene glycol (1,3-BG) solution 1,000 mL
And extract for 3 days at room temperature, then filter to obtain an extract (containing 1.2 to 1.9 ^w / _v % dry solids).

[0015]

[Example] Production Example 2 100 g of button beetle was added to 1,500 mL of 50% ethanol solution, or 40
% 1,3-butylene glycol solution Soak in 1,500 mL, extract at room temperature for 3 days and night, then filter to extract (dry solids
0.8-1.5 ^w / _v % included).

[0016]

[Examples] Production Example 3 100 g of the salsa gauze was added to 1,000 mL of a 50% ethanol solution, or
Immerse it in 1,000 mL of 40% 1,3-butylene glycol solution,
After extracting at room temperature for 7 days, it is filtered to obtain an extract (containing a dry solid content of 1.0 to 2.3 ^w / _v %).

[0017]

Example 4 Production Example 4 100 g of perilla was 8,000 mL of a 35% ethanol solution, or 50% 1,
Soak in 5,000 mL of 3-butylene glycol solution, extract at room temperature for 3 days, and then filter to extract (dry solid content 0.1
~ 0.22 ^w / _v % included).

[0018]

Example 5 Production Example 5 100 g of Dokudami was added to 1,000 mL of 40% ethanol solution, or 50
After dipping in 1,000 mL of a 1,3-butylene glycol solution, extract at room temperature for 7 days, then filter to extract (dry solid content).
0.6-1.2 ^w / _v % included).

[0019]

Example 6 Production Example 6 100 g of mint was immersed in 2,000 mL of purified water and 200 mL of 1,3-butylene glycol solution, respectively, extracted for 7 days at room temperature, filtered and mixed with each extract, An extract containing 1.6-3.0 ^w / _v % dry solids is obtained.

The external preparation for skin according to the present invention is produced by formulating the specified essential plant components together with the bases and additives usually used in external preparations. For example, oils include animal and vegetable oils, mineral oils, ester oils, wax oils, higher alcohols, fatty acids, silicone oils, phospholipids and the like. As the surface active agent, an anionic surface active agent, a cationic surface active agent, an amphoteric surface active agent, a nonionic surface active agent or the like is used. Others, p-aminobenzoic acid, anthranil derivative, salicylic acid derivative, coumarin derivative, amino acid compound, benzotriazole derivative, tetrazole derivative, imidazoline derivative, pyrimidine derivative, dioxane derivative, camphor derivative, furan derivative, pyrone derivative, nucleic acid derivative, allantoin UV absorbers such as derivatives, nicotinic acid derivatives, shikonin, vitamin B ₆ derivatives, ascorbic acid and its salts, stearic acid ester, tocopherol and its ester derivatives, nordihydroguaselethenoic acid, butylhydroxytoluene (BHT), butylhydroxy Antioxidants such as anisole (BHA), para-hydroxyanisole, propyl gallate, hydroxyethyl cellulose, methyl cellulose, ethyl cellulose, carboxy Methyl cellulose, carboxymethyl cellulose, gum arabic, polyvinyl alcohol, polyvinyl pyrrolidone, polyvinyl methacrylate, polyacrylic acid salts,
Carboxyvinyl polymer, carrageenan, pectin,
Alginic acid and its salts, casein, thickeners such as gelatin, glycerin, propylene glycol, 1,3-butylene glycol, hyaluronic acid and its salts, polyethylene glycol, chondroitin sulfate and its salts, water-soluble chitin or chitosan derivative, sodium lactate. Moisturizers such as, lower alcohols, polyhydric alcohols, water-soluble polymers, pH adjusters, chelating agents, antiseptic / antifungal agents, fragrances, colorants, cooling agents, stabilizers, extractions originating from animals and plants Substances, animal / vegetable proteins and their degradation products, animal / vegetable polysaccharides and their degradation products, animal / vegetable glycoproteins and their degradation products, blood flow promoters, anti-inflammatory / anti-inflammatory agents, cell activating agents, vitamins , Amino acids and their salts, keratolytic agents,
Astringents, wound healing agents, foam boosters, deodorants / deodorants, etc. may be used in combination as necessary to produce the above-mentioned various products.

In addition to the essential plant components in the external preparation for skin of the present invention, it is of course possible to additionally use a plant extract already known to have anti-inflammatory and anti-allergic actions. Plants or herbal medicines that are said to have such effects include, for example, arnica, aloe,
Angelica, Prickly pear, Turmeric, Scutellaria, Psyllium, Coptis, Hypericum, Stinkweed, Spruce, Kasitsu, Kagosou, Cuckoo, Kanosou, Birch, Chamomile, Kakuraku, Kakune, Kiku, Kuku, Kuku, Kuku, Cucurbita , Kouhon, kotsusaiho, burdock, salvia, sardine, citrus, konjac, linden, zebra, peony, jiu, shouma, juzdama,
White birch, horsetail, horse mackerel, horse chestnut, horse chestnut, elderberry, saw palmetto, millet, rainbow trout, senkyu, medusa, senburi, rhubarb, thyme, thyme, dandelion, ginseng, daffodil, tsuwabuki, touka, sugar beet, sugar beet, tomato , Trolley mallow, elderberry, carrot, thistle, parsley, hydrangea, rose, hisb, juniper, blunt, coltsfoot, humor, safflower, safflower, bodaiju, hops, horse chestnut, myrrh, swordfish, merlot, melissa, peach leaf, cornflower, mistletoe, mistletoe.
Examples include moss, eucalyptus, yukinoshita, yokinin, yomena, mugwort, lavender, gentian, forsythia, rosemary, and chamomile.

The essential plant component in the external preparation for skin of the present invention is not particularly limited in the amount to be blended, but when it is intended to improve skin trouble in a short period of time, it is usually a total amount of dry solids. It is preferable to mix it in any proportion within the range of 0.005 to 2% by weight. Further, in the case of a bath agent, the formulation may be taken into consideration so that the same concentration is obtained by throwing it in a bath water of 200 to 300 liters. On the other hand, for such various skin troubles, such as skin cosmetics and hair care agents that are used on a daily basis, for the purpose of preventive purposes only, or gradually improving by cumulative effect, Alternatively, in the case of product forms such as bath agents, the amount normally prescribed in the field (as the total dry solid content is
It is considered that the desired effect is sufficiently expected even with (0.001 to 0.5% by weight). The mixing ratio of the plant components to be used in combination is not particularly limited, but as a guideline, it is desirable to prescribe the solid content ratio to be an approximately equal ratio.

[0023]

[Examples] Histamine release inhibitory effect In a type I allergic reaction, inflammatory substances such as histamine are released from mast cells or basophils sensitized in the second step. Therefore, substances that suppress histamine release can be expected to have a preventive effect on allergic inflammatory diseases. In this test, it was examined according to a test method (J. Soc. Cosmet. Japan, 25 (4), P246 (1992)) of releasing histamine from rat mast cells with Compound 48/80 which is a histamine releasing reagent. (Test method) a. The solvent was distilled off from the sample extract under reduced pressure, and the extract was redissolved in purified water to a solid concentration of 0.1 ^w / _v % and subjected to the test. Also,
In the case of combined use, they were redissolved so that each solid content concentration became 0.1 ^w / _v %. b. Measurement of free histamine amount A sample (0.5 mL) was added to a mast cell suspension (3 mL) collected from the abdominal cavity of a rat (Slc: Wister male rat, about 7 to 9 weeks old).
mL) and Compound 48/80 (amount giving a final concentration of 1 μg / mL) were added, and the mixture was incubated at 37 ° C. for 15 minutes. After the reaction was stopped by cooling with ice, the reaction solution was centrifuged, and histamine released from the supernatant was extracted and purified, and color was developed with o-phthaldialdehyde, and the fluorescence intensity at an excitation wavelength of 350 nm and a fluorescence wavelength of 450 nm was measured. The histamine release inhibition rate was calculated by the following formula (Equation 1).

[Equation 1]

(Test Results) As shown in Table 2, it was confirmed that the combination of the specific plant components according to the present invention exhibits a synergistic effect, which greatly exceeds the sum of the histamine release inhibiting effects when each of them is used alone. It was

[Table 1]

[Table 2]

[0025]

[Examples] Anti-complement activity action Since the complement system is greatly involved in type II and type III allergic reactions, it is possible to evaluate the effect on allergy by measuring complement activity. In this test, the extracts obtained in Production Examples were examined using an anti-complement action measuring method using the hemolytic reaction of sensitized red blood cells as an index.

(Test method) a. Gelatin / Veronal buffer (GVB ²⁺ ) Sodium chloride 1.7g, barbital 0.115g, barbital sodium 0.075g, calcium chloride 0.015g, magnesium chloride 0.010g, gelatin 0.2g, purified water 100mL are mixed and adjusted to pH 7.5. Then, the total volume was adjusted to 200 mL with purified water. b. Sheep erythrocyte (SRBC) suspension The sheep blood cells were centrifuged at 2,000 rpm for 5 minutes, washed 3 times with physiological saline, and GVB ²⁺ was added to the precipitate to make a 10% SRBC suspension, and finally SRBC. 3.05 in 0.25 mL of suspension
When 0.1 mL of 0.1% sodium carbonate solution was added for complete hemolysis, the absorbance at 540 nm was adjusted to 0.455. c. 0.2 mL of 10% SRBC suspension in anti-SRBC mouse serum was intravenously injected into the tail of an IVCS male mouse, and 4 days later, blood was collected and serum was separated.
It was used after being diluted 40-fold with B ²⁺ . d. Complement Guinea pig fresh serum was diluted 20-fold with GVB ²⁺ and used. e. After the solvent was distilled off from the sample extract under reduced pressure, it was redissolved in purified water to a solid content concentration of 0.1 ^w / _v % and subjected to the test. A 0.2 ^w / _v % dipotassium glycyrrhizinate aqueous solution was used as a positive control. f. Anti-complement activity measurement GVB 2 ⁺ 1.2 mL, sample 0.1 mL + purified water 0.1 mL, total 0.2 mL
(In case of using 2 kinds in combination, 0.1 mL each, total 0.2 mL) and anti-S
RBC serum 0.5mL, SRBC suspension 0.25mL, complement solution 0.2
After adding 5 mL sequentially, the mixture was reacted for 60 minutes in a constant temperature bath at 37 ° C. After leaving the reaction solution in ice water for 10 minutes to stop the reaction, the reaction solution was centrifuged at 2,000 rpm for 10 minutes to separate unlysed red blood cells, and then the OD value of the supernatant at 540 nm was measured. It should be noted that instead of the sample, 0.2 mL of purified water was added as a control, and a blank containing no serum was set for each sample and control, and the complement inhibition rate (= anti-complement activity) was calculated by the following formula (Equation 2). ) Was asked.

[Equation 2]

(Test Results) As shown in Table 4, it was confirmed that the combination of the specific plant components according to the present invention exhibits a synergistic effect, which is much higher than the sum of anti-complementary activity when each of them is used alone. Was done.

[Table 3]

[Table 4]

[0028]

[Examples] Safety test 1) Primary skin irritation test Each of the plant extract components obtained in Production Examples 1 to 6 was readjusted to each solid content concentration, and the back was hair-removed Hartley guinea pig (5 in 1 group). It was applied to the skin of an animal (body weight: about 320 g). The evaluation was performed 24 hours after application by using the erythema and edema as indices by the primary irritant scoring method. The results are shown in the following table (Table 5), and in all animals, no erythema or edema was observed, and it was determined to be negative.

[Table 5]

[0029]

[Examples] Safety test 2) Skin cumulative irritation test Each of the plant extract components obtained in Production Examples 1 to 6 was used as a solid content at a concentration of 1 ^W / _V % (in the case of using two kinds in combination, each plant extract was extracted. Once a day on the skin of Hartley guinea pigs (female, 5 animals per group, body weight 320g) with the abdomen shaved after adjusting to an aqueous solution with a solid content of 1 ^W / _V %) 0.5 mL / animal was applied 5 times a week. The application is
Hair removal was performed over 4 weeks and on the last application day of each week. Judgment was performed on the day after the last day of each week by the scoring method for primary irritation, using erythema and edema as indexes. The results are shown in the following table (Table 6). Negative erythema and edema were not observed in all animals from 1 to 4 weeks after application, and the results were determined to be negative.

[Table 6]

[0030]

[Examples] Safety test 3) Acute toxicity test Various extracts obtained in Production Examples 1 to 6 are concentrated under reduced pressure and then dried. Before the test, 2,000 mg / kg was orally administered to ddy mice (female, 5 mice per group, body weight 28 g) that had been fasted for 4 hours, and the onset and extent of toxic symptoms were observed over time. As a result, no abnormality was observed in all mice for 14 days, and there was no abnormality in the autopsy result. LD ₅₀ is 2,
It was determined to be 000 mg / kg or more.

[0031]

Examples Production of various external preparations According to the above evaluation results, various external preparations were produced based on the combination of the plant extract components showing the synergistic effect.
The formulation examples are shown below, but the external preparation for skin according to the present invention is not limited thereto.

1) Production Example of Lotion A lotion was produced according to the following formulation. Weight% 1. Sorbit 2 2.1,3-butylene glycol 2 3. Polyethylene glycol 1000 1 4. Polyoxyethylene oleyl ether (25E.O.) 2 5. Ethanol 10 6. Loquat leaf 40% EtOH extract (solid content 1.6%) 5 7. Botanpi 40% 1,3-BG extract (solid content 1.2%) 5 8. Suitable pH adjuster 9. Preservative appropriate amount 10. Residue of purified water 100

2) Production Example of Emulsion An emulsion was produced according to the following formulation. Weight% 1. Squalane 3 2. Vaseline 1 3. Stearyl alcohol 0.3 4. Sorbitan monostearate 1.5 5. Polyoxyethylene (20) sorbitan monooleate 3 6.1,3-butylene glycol 5 7. Loquat leaf 50% 1,3-BG extract (solid content 1.7%) 58. 40% 1,3-BG extract (solid content 1.6%) 5 9 Preservative appropriate amount 10. Residue of purified water 100

3) Cream Production Example A cream was produced according to the following formulation. Weight% 1. Squalane 20 2. Beeswax 5 3. Refined jojoba oil 5 4. Glycerin monostearate 2 5. Sorbitan monostearate 2 6. Polyoxyethylene (20) sorbitan monostearate 2 7. Glycerin 5 8. Dokudami 40% 1,3-BG extract (solid content 1.2%) 5 9. Mint extract of Production Example 6 (solid content: 2.2%) 3 10. Preservative proper amount 11. Residue of purified water 100

4) Production Example of Body Soap A body soap was produced according to the following formulation. Weight% 1. Potassium laurate 15 2. Potassium myristate 5 3. Propylene glycol 5 4. Botanpi 50% 1,3-BG extract (solid content 1.1%) 5 5. Perilla purified water extract (solid content 0.2%) 10 5. pH adjuster Appropriate amount 6. Preservative proper amount 7. Residue of purified water 100

5) Shampoo Production Example A shampoo was produced according to the following formulation. Weight% 1. Lauryl sulfate triethanolamine 5 2. Polyoxyethylene lauryl ether sulfate Na 12 3.1,3-butylene glycol 4 4. Lauric acid diethanolamide 2 5. Disodium edetate 0.1 6. Botanpi 40% 1,3-BG extract (solid content 1.0%) 5 7. 7. Mint extract of Production Example 6 (solid content: 2.2%) 3 8. Preservative proper amount 9. Residue of purified water 100

6) Rinsing Production Example A rinse was produced according to the following formulation. Weight% 1. Stearyl trimethyl ammonium chloride 2 2. Cetostearyl alcohol 2 3. Polyoxyethylene lanolin ether 3 4. Propylene glycol 5 5. Botanpi 40% 1,3-BG extract (solid content 1.0%) 5 6. Dokudami 40% 1,3-BG extract (solid content 1.2%) 5 7. pH adjuster proper amount 8. Preservative proper amount 9. Residue of purified water 100

7) Production Example of Hair Liquid A hair liquid was produced according to the following formulation. Weight% 1. Ethanol 29 2. Polyoxypropylene butyl ether phosphoric acid 10 3. Polyoxypropylene monobutyl ether 5 4. Triethanolamine 1 5. Botanpi 50% EtOH extract (1.2% solids) 3 6. Loquat leaf 40% EtOH extract (solid content 1.6%) 3 7. Preservative proper amount 8. Residue of purified water 100

8) Production Example of Heartonic The Heartonic was produced by the following formulation. Weight% 1. Ethanol 40 2. Ethyl oleate 1 3. Polyoxyethylene (40) hydrogenated castor oil 2 4. Botanpi 50% EtOH extract (1.1% solids) 5 5. 5. Mint extract of Production Example 6 (solid content: 2.2%) 3 6. Perilla 35% EtOH extract (solid content 0.2%) 10 7. Residue of purified water 100

9) Production Example of Bath Agent A granule type bath agent was produced according to the following formulation. Weight% 1. Sodium hydrogen carbonate 52 2. Anhydrous sodium sulfate 25 3. Borax 2 4. Dry powder of loquat leaf 60% EtOH extract 7 5. Dry powder of Botanpi 60% EtOH extract 7 6. Dry powder of 60% EtOH extract of salamander 7

[0041]

[Example] Use test of various external preparations Male and female panelists suffering from troubles such as inflammatory diseases of the skin and head can freely use the lotion, shampoo, rinse and bath preparation produced in the examples for one month, We asked for a questionnaire survey on usability. The results are shown in the following table (Table 7).

[Table 7]

[0042]

Industrial Applicability The skin external preparation or bath preparation containing a combination of specific plant extract components according to the present invention is extremely effective for the prevention and alleviation of allergic skin inflammatory diseases and rough skin, and prevention of skin aging. And
Moreover, it is highly safe. The effect is synergistically exhibited by the combination of the plant extract components specified in the present invention. Allergic skin inflammatory diseases (eg, redness, eczema, edema, swelling, atopic dermatitis), rough skin,
It has been pointed out that skin problems such as dry skin are associated with hypersensitivity, and the number of people worried about it is increasing year by year.
In the present invention, these problems are prevented or improved,
It is intended to provide an external preparation for the skin or a bath preparation for the purpose of adjusting the texture of the skin and keeping it healthy.

─────────────────────────────────────────────────── ───Continued from the front page (51) Int.Cl. ⁶ Identification code Internal reference number FI technical display area A61K 7/50

Claims (3)

[Claims] 1. A skin external preparation or bath preparation, which is prepared by using the following (1) and (2) together as essential ingredients. (1) An extract component obtained by using loquat leaf water, ethanol, 1,3-butylene glycol, or a mixed solution of two or more thereof. (2) Extraction component obtained using one or two kinds of water, ethanol, 1,3-butylene glycol, or a mixed liquid of two or more kinds thereof selected from pearl pea and salamander. 2. An external preparation for skin or bath preparation, which is prepared by combining the following (1) and (2) as essential ingredients. (1) Extraction component obtained by using water, ethanol, 1,3-butylene glycol, or a mixture of two or more of these. (2) An extract component obtained by using one or two or more kinds of water selected from perilla, Dokudami, and mint, water, ethanol, 1,3-butylene glycol, or a mixed solution of two or more kinds thereof. 3. An external preparation for skin or bath preparation, which is prepared by combining the following (1) and (2) as essential ingredients. (1) An extract component obtained by using Dokudami water, ethanol, 1,3-butylene glycol, or a mixed solution of two or more thereof. (2) Extracted component obtained by using water of mint, ethanol, 1,3-butylene glycol, or a mixed solution of two or more of these.