JP2001081021A - Cosmetic composition - Google Patents

Abstract

PROBLEM TO BE SOLVED: To obtain a cosmetic composition containing a safe active oxygen scavenger, capable of mitigating fleckles, improving dermal inflammatory diseases/rough skin/dry skin and giving the skin luster/firmness by including an extract from Cassia alata Linn. and polyphenol derivatives. SOLUTION: This cosmetic composition contains (A) an extract from Cassia alata Linn. and (B) polyphenol derivatives (e.g. tannin derivatives). The ingredient A is obtained by the following practice: the stems, leaves/twigs, barks, flowers, buds, berries, skins and/or berry ears of Cassia alata Linn., a plant belonging to the leguminous family, are subjected to extraction with an appropriate solvent to extract the active ingredient therein, the resultant extraction liquid is filtered, and as necessary, the resultant filtrate is diluted, or concentrated and then evaporated to dryness. The contents of the ingredients A and B in this cosmetic composition are normally >=0.001 wt.%, pref. 0.01-10 wt.%, on a dry basis, and normally >=0.00001 wt.%, pref. 0.00005-10 wt.% respectively.

Description

DETAILED DESCRIPTION OF THE INVENTION

[0001]

TECHNICAL FIELD The present invention relates to an active oxygen scavenger, an inhibitor of lipid peroxide production, an antiallergic agent, and a pharmaceutical, quasi-drug or cosmetic product, characterized by containing an extract of oil palm and a polyphenol derivative. To various cosmetic compositions.

[0002]

2. Description of the Related Art In recent years, the production of active oxygen in a living body and various effects (diseases) caused thereby have been reported. Generally, this active oxygen is also called Activated oxygens, and includes O ²⁻ , H ₂ O ₂ , .OH, and chemiluminescence.
They are roughly classified into species, all of which have strong bactericidal action and are considered important substances involved in the self-defense of living organisms. For example, foreign enemy (antigen) such as bacteria / viruses and foreign substances
When phage enters the living body, neutrophils, monocytes, and macrophages, which are phagocytes in the blood, start phagocytosis,
In order to dissolve phagocytosed foreign substances in the phagocyte,
Active oxygen is produced, and this produced active oxygen not only dissolves phagocytic foods, but also has a bactericidal action against external enemies such as bacteria and foreign substances, and has a role to protect against external enemies. Play. In other words, it has the function of eliminating antigenic substances before the immune function works.

[0003] However, if the active oxygen for self-protection is produced and secreted in excess, even normal cells are lysed and stimulated, resulting in various damage reactions. Recently, many diseases and diseases caused by active oxygen have been reported. For example, fats and oils such as cholesterol in blood are oxidized by active oxygen, and vascular disorders due to arteriosclerosis in the brain and heart (stroke, myocardial infarction, etc.) ) And brain trauma, it is said to cause ischemic state in blood vessels due to rapid transient atrophy such as impaired blood flow due to thrombus, resulting in anoxia. Therefore, in this state, it is said that xanthine dehydrogenase in the blood vessel is converted to xanthine oxidase, which generates a large amount of active oxygen in the blood in the blood vessel, causing damage to the blood vessel wall and causing fatal damage I have.

[0004] Further, regarding the relationship between the skin and active oxygen, for example, since the skin is an organ in direct contact with the outside world, it is susceptible to environmental factors. If the state continues, it reacts with the unsaturated fatty acids of the phospholipids of the biological membrane, and the lipid peroxides are generated. It is thought that the produced lipid peroxide causes arteriosclerosis, carcinogenesis, aging, membrane destruction, protein denaturation, etc., and also causes skin inflammation, edema, wrinkles and the like. Furthermore, as a disease due to an excess of active oxygen, from a cosmetic point of view, for example, herpetic dermatitis, X-ray dermatitis, burns, trauma, solar dermatitis, contact dermatitis,
Examples include eczema and atopic dermatitis. Therefore, there is a need for a substance that eliminates excessive active oxygen existing in a living body, such as superoxide dismutase (SOD), catalase, glutathioperoxidase, and other substances such as tocopherol (vitamin E), oryzanol, and plant extract. (Hammelis, Melissa, Emmeso, Birch, Sage, Rosemary, Ages, Basil, Ginkgo, Psycho, Peony, Hange, Keihi,
Typhoids, Japanese gourds, carrots, licorice, ginger) and the like have been used. In addition, as a lipid peroxide production inhibitor, β
-Carotene, plant extracts (sesame cultured cells, amacha, Hypericum perforatum, Hamamelis, Melissa, Emmeiso, birch, sage, rosemary, Nanami, Eijitsu, Ginkgo, green tea) and the like were known.

On the other hand, due to the recent deterioration of environmental conditions, changes in lifestyle, and increased stress due to the complication of social life, hay fever, allergic rhinitis, bronchial asthma, atopic dermatitis, drug-induced urticaria, etc. More and more people suffer from allergic diseases, rough skin, dry skin and the like. In particular, atopic dermatitis has been attracting attention as one of the modern illnesses, as its increase is screaming not only in children but also in a wide range of ages up to adults.

[0006] In order to eliminate foreign substances (bacteria, pollen, ticks, etc .: antigens) originally, the living body must produce biological components (antibodies, lymphocytes, etc.) to counter it and protect the body. It has an immune function that works. However, sometimes the reaction becomes too sensitive and harmful to the body,
It can cause various diseases. The disorder reaction caused by this immune function is called allergy, and is classified into immediate type and delayed type.

[0007] In the allergic reaction, the frequency of onset is immediate type (types I to III), and mainly immunoglobulin E (I
gE) Reaction involving antibodies. This IgE is produced for allergens that have invaded the body and has a strong effector effect on mast cells and basophils.
Mast cells and basophils (a type of leukocyte) are cells having granules containing pharmacologically active amines such as histamine and serotonin, the former being present around blood vessels and connective tissues, and the latter being present in blood. On these cell membranes, there is a receptor that binds IgE antibodies and has the property of strongly binding to IgE antibodies, and when the same type of allergen binds again to IgE antibodies bound to mast cells and basophils A large number of active substances such as histamine and serotonin described above are released from the cells with degranulation, which causes various allergic symptoms. Symptoms such as redness and rash (urticaria) with itchiness on the skin, inflammation of the nose and eyes and itching and increased secretion of nasal discharge and tears, or difficulty in breathing due to congestion of the trachea Symptoms such as seizures (bronchial asthma) are classified as allergic diseases of this type.

[0008] In the case of immediate allergy, the process can be roughly classified into three stages, which are classified into each stage from the point of action, and attempts are made to prevent, alleviate or treat allergic diseases by administering drugs or the like. I have been. That is, when a foreign antigen enters the body, an IgE antibody is produced by an immunocompetent cell line, and the IgE antibody is distributed in airway, skin, digestive organs and other mast cells that are likely to cause allergic reactions, or in the blood. Sensitization is established by sticking to basophils.
This is the reaction referred to as the first step.

Next, when the sensitized cells are again contacted with an antigen, the cells undergo morphological changes such as vacuolation, swelling, and degranulation, and release chemical transmitters such as histamine, serotonin, and SRS-A. I do. This is the second stage reaction.

The released chemical messenger acts on contraction of smooth muscles such as bronchial muscles and gastrointestinal tract, enhancement of capillary permeability, migration of neutrophils, aggregation of platelets, and the like. The process of developing allergic symptoms such as gastrointestinal allergy with diarrhea, nasal allergy, and urticaria is the third stage reaction.

Therefore, in a narrow sense, drugs acting in the first and second stages are prophylactics for allergic reactions,
Those acting in stages can be considered as symptomatic treatments. Currently, the most active research on antiallergic drugs is the development of drugs that suppress this second stage.

[0012] Type II allergy is known as a damage reaction caused by the destruction of tissue cells by IgG or IgM antibodies. IgG and IgM antibodies acting on this system significantly activate the complement system when linked to an antigen. (Effector action). The reaction mechanism is based on the fact that IgG and IgM antibodies bind to antigen cells such as microorganisms, thereby activating the complement system and destroying target cells.

[0013] The function of the complement system is to activate the protease system on the target cells in a chain, to form and destroy the membrane damage complex (MAC), and to generate a group of fragments called anaphylatoxins. It takes complex steps such as promoting histamine release from mast cells and attracting polymorphonuclear leukocytes and macrophages to promote foreign body treatment. However, such reactions are caused by virus-infected autologous cells, tissue cells or erythrocytes to which haptens (substances that are not antigenic in nature but produce antibodies when bound to proteins, etc.) or bacteria are bound or adhered. In an immune disease, even if the cells are in their own normal cells, the living body recognizes and causes them as antigen cells. Typical types II allergic diseases include aplastic anemia and hemolytic anemia.

[0014] Type III allergy is a reaction in which a large amount of an antigen-antibody conjugate formed by the binding of an antibody to an antigen is deposited and damaged in a tissue. Antibodies involved in this reaction are mainly IgG antibodies, which are reactions involving many factors such as the complement system and polymorphonuclear leukocytes, similar to type II, but the difference from type II is that the antigen is not a cell but a substance Is a major feature. still,
The reaction mechanism is that the produced antigen-antibody conjugate is deposited on tissues such as blood vessels, kidneys, joints, and skin to activate the complement system (effector effect). As a result, a large amount of anaphylatoxin is produced, which increases vascular permeability, contracts smooth muscle, and promotes the release of histamine from mast cells, resulting in inflammation.

Various test methods have been proposed according to the allergic reaction types classified as described above, and approaches to factors effective for preventing or ameliorating allergic diseases have been actively conducted.

[0016]

However, the active oxygen-scavenging substance and the lipid peroxide-inhibiting substance described above have poor stability and solubility in the formulation system, and give off odor and color due to precipitation and decomposition. In addition, the effect at the biological level is not sufficient, and further, there is a problem in terms of safety such as causing rash on the skin, and it has not been satisfactory.

Many of the conventionally used antiallergic agents are agents relating to diseases caused by an immediate allergic reaction whose action point is relatively clear.
For example, for type I allergies, antispasmodics that relax smooth muscle, sympathomimetics that suppress the increase in capillary permeability, and antihistamines are listed. Although it is a drug that acts at a stage and is effective as a symptomatic treatment, most of it is a synthetic drug and has a problem in side effects. Furthermore, active researches have been conducted on the development of drugs effective for type II and III allergies, but at present, no specific antiallergic agent has been found yet.

On the other hand, the most active research on antiallergic agents involved in immediate-type allergic diseases is a drug that suppresses the release of chemical mediators and exhibits an antagonistic effect on the released chemical mediators. Although the development of drugs that suppress the second stage, such as drugs, has not been found to have sufficient efficacy at present.

[0019]

In view of these circumstances, the present inventors have found that active oxygen scavenging (SOD) action, lipid peroxide production inhibitory action, and anti-allergic action (histamine release inhibitory action, anti-captor activity) have been achieved. The theme of the development is a useful plant, and as a result, the active oxygen is significantly eliminated / suppressed by using a combination of oil palm extract and polyphenol derivative. In addition, the production of lipid peroxide should be suppressed. Furthermore, a histamine release inhibitory action and an anti-complement activity were confirmed. In addition to reducing wrinkles and wrinkles on the skin, it also improves skin inflammatory diseases (eg, redness, edema, eczema, etc.), improves rough and dry skin, and also gives the skin a gloss and firmness. The present invention has been completed by providing an active oxygen scavenger, a lipid peroxide production inhibitor, an antiallergic agent, and a cosmetic composition having a high content.

[0020]

BEST MODE FOR CARRYING OUT THE INVENTION The term "Salvia serrata: anti-bean" used in the present invention refers to a leguminous plant: saccharomyces oleracea (Cas
sia alata Linn), also known as: Golden Candle, African Mokuto, Yusuketsumei, Hane Senna, stem,
Branches and leaves, leaves, bark, flowers, flower buds, fruits, pericarp, ears and the like are used, but other congener plants such as alexandria senna, namban locust, chineberi senna, kawataketsumei, shrimp grass, habusaw, cassia tola and the like can also be used. .

The active ingredient is extracted from the plant using a suitable solvent. Solvents include water, alcohols (for example, lower alcohols such as methanol, anhydrous ethanol and ethanol, or polyhydric alcohols such as propylene glycol and 1,3-butylene glycol) or ketones such as acetone, ethyl ether, dioxane, and acetonitrile. , Esters such as ethyl acetate, xylene,
Organic solvents such as benzene and chloroform can be used alone or as a mixture of two or more.
Further, it can be used in a state where each solvent extract is combined. After the extraction, the extract is filtered and, if necessary, the extract is diluted, concentrated or dried.

Although the production method is not particularly limited, it may be usually within the range of the boiling point of the solvent at normal temperature and normal pressure.
A solution, paste, gel, or powder may be obtained by decoloring and purifying. In many cases, it can be used as it is, but if necessary, further purification treatment such as deodorization and decolorization may be added as long as the effect is not affected. An activated carbon column or the like may be used, and ordinary means generally applied to the extracted substance may be arbitrarily selected.

Although the content of the oil palm extract in the present invention is not particularly limited, the types, qualities and expected effects of active oxygen scavengers, lipid peroxide production inhibitors, antiallergic agents and cosmetic compositions are considered. The dry extract content is usually 0.001% by weight or more, preferably 0.01 to 10% by weight. If the content is less than 0.001%, a sufficient effect cannot be expected.

The term "polyphenol derivative" refers to a compound having two or more phenolic hydroxyl groups and derivatives thereof, for example, phloroglucinol derivatives such as phloroglucinol, aspidine, and aspirinol; gallic acid, gallic acid Acid esters (propyl ester, isoamyl ester, octyl ester, dodecyl ester, etc.), pyrogallol, phloroglysin, catechin, epicatechin, gallocatechin, catechin gallate, gallocatechin gallate, epicatechin gallate, epigallocatechin gallate, epigallocatechin, glucogalin , Proanthocyanidins and polymers thereof, flavones (eg, rutin, quercetin, quercetagine, quercetagitin, gossypetin, etc.), ellagic acid, penta-O-galloylgue Course, tannic acid, gallotannin, ellagitannin, the like can also be used tannin derivatives, such as condensed tannins, particularly tannins derivatives of these are preferable.

Although the content of these polyphenol derivatives is not particularly limited, the type, quality and expected degree of action of active oxygen scavenger, lipid peroxide production inhibitor, antiallergic agent and cosmetic composition are considered. Depends slightly on
Usually, the content is 0.00001% by weight or more, preferably 0.00005 to 10% by weight. If the content is less than 0.00001%, a sufficient effect cannot be expected.

[0026] Crude drugs and plant extracts containing polyphenol derivatives can also be used. That is, tannin crude drugs obtained from mimosa, kepratio, cushite, asenyaku, quintessence, gallicia, and the like, and plant extracts obtained from the following protophytes and the like can be mentioned. For example,
Arnica, birch, calendula, chamomile, hamamelis, rosemary, sage, carob, henna, hop, lime, bodaige, aloe, thyme, wild thyme, calendula, horsetail, mountain gentiana,
Stinging nettle, horse chestnut, avocado, achillea millefolium, coltsfoot, peach, rose, senna, white lily, teuchigurumi, gennoshoko, red pike, button, peonies, rhinoceros, oak, oak, oak, squirrel, occidental Mugwort, saxifrage, pomegranate, oyster, tea, black tea, oolong tea, grape, katsura, kina, holtoki, cod, oak, mangrove, tsuldokudami, forsythia and the like can be mentioned.

The active ingredient is extracted from the plant using a suitable solvent. Solvents include water, alcohols (for example, lower alcohols such as methanol, anhydrous ethanol and ethanol, or polyhydric alcohols such as propylene glycol and 1,3-butylene glycol) or ketones such as acetone, ethyl ether, dioxane, and acetonitrile. , Esters such as ethyl acetate, xylene,
Organic solvents such as benzene and chloroform can be used alone or as a mixture of two or more.
Further, it can be used in a state where each solvent extract is combined. After the extraction, the extract is filtered and, if necessary, the extract is diluted, concentrated or dried.

Although the production method is not particularly limited, it may be usually within the range of the boiling point of the solvent at normal temperature and normal pressure. After extraction, filtration or use of an ion exchange resin is carried out.
A solution, paste, gel, or powder may be obtained by decoloring and purifying. In many cases, it can be used as it is, but if necessary, further purification treatment such as deodorization and decolorization may be added as long as the effect is not affected. An activated carbon column or the like may be used, and ordinary means generally applied to the extracted substance may be arbitrarily selected.

The content of the plant extract containing a polyphenol in the present invention is not particularly limited. However, the type, quality and quality of active oxygen scavenger, lipid peroxide production inhibitor, antiallergic agent and cosmetic composition are not limited. Slightly different depending on the expected degree of action, usually 0.001 as dry extract
% By weight or more, preferably 0.01 to 10% by weight. If the content is less than 0.001%, a sufficient effect cannot be expected.

The mixing ratio of the oil palm extract and the polyphenol derivative in the present invention is not particularly limited, but is usually about 1: 0.01 to 0.01: 1, preferably 0.1 to 0.01.
1: 1 to 1: 0.1 is good.

The active oxygen scavenger, lipid peroxide production inhibitor, antiallergic agent and cosmetic composition of the present invention may be used in addition to the above-mentioned essential components, if necessary, within a range that does not impair the effects of the present invention. It can be manufactured by arbitrarily selecting and using components and additives used in preparations such as pharmaceuticals, quasi-drugs, and cosmetics.

(1) Various fats and oils Avocado oil, almond oil, fennel oil, perilla oil,
Olive oil, orange oil, orange luffer oil, sesame oil, cocoa butter, chamomile oil, carrot oil, cucumber oil, tallow fatty acid, kukui nut oil, safflower oil, shea butter, liquid shea fat, soybean oil, camellia oil, corn oil, rapeseed Oil, persic oil, castor oil, cottonseed oil, peanut oil, turtle oil, mink oil, egg yolk oil, palm oil, palm kernel oil, mocro, coconut oil, tallow, lard, or hydrogenated products of these oils (hardened oil, etc.) )Such.

(2) waxes Beeswax, carnauba wax, whale wax, lanolin, liquid lanolin, reduced lanolin, hard lanolin, candelilla wax,
Montan wax, shellac wax, rice wax, squalene, squalane, pristane, etc.

(3) Mineral oil Liquid paraffin, vaseline, paraffin, ozokeride, ceresin, microcrystalline wax and the like.

(4) Fatty acids Natural fatty acids such as lauric acid, myristic acid, palmitic acid, stearic acid, behenic acid, oleic acid, 12-hydroxystearic acid, undecylenic acid, tall oil, lanolin fatty acid, isononanoic acid, caproic acid Synthetic fatty acids such as, 2-ethylbutanoic acid, isopentanoic acid, 2-methylpentanoic acid, 2-ethylhexanoic acid and isopentanoic acid.

(5) alcohols ethanol, isopiranol, lauryl alcohol,
Natural alcohols such as cetanol, stearyl alcohol, oleyl alcohol, lanolin alcohol, cholesterol, phytosterol, 2-hexyldecanol,
Synthetic alcohols such as isostearyl alcohol and 2-octyldodecanol.

(6) Polyhydric alcohols Ethylene oxide, ethylene glycol, diethylene glycol, triethylene glycol, ethylene glycol monoethyl ether, ethylene glycol monobutyl ether, diethylene glycol monomethyl ether, diethylene glycol monoethyl ether, polyethylene glycol, propylene oxide, propylene glycol , Polypropylene glycol, 1,3-butylene glycol, glycerin, pentaerythritol, sorbitol, mannitol and the like.

(7) Esters Isopropyl myristate, isopropyl palmitate, butyl stearate, hexyl laurate, myristyl myristate, oleyl oleate, decyl oleate, octyl dodecyl myristate, hexyl decyl dimethyloctanoate, cetyl lactate, Myristyl lactate, diethyl phthalate, dibutyl phthalate, lanolin acetate, ethylene glycol monostearate, propylene glycol monostearate, propylene glycol dioleate and the like.

(8) Metal soaps Aluminum stearate, magnesium stearate, zinc stearate, calcium stearate, zinc palmitate, magnesium myristate, zinc laurate, zinc undecylenate and the like.

(9) Gum, sugar or water-soluble polymer compound Arabic gum, benzoin gum, dammar gum, guaiac oil, Irish moss, karaya gum, tragacanth gum,
Carob gum, quinseed, agar, casein, lactose,
Fructose, sucrose or its ester, trehalose or its derivative, dextrin, gelatin, pectin, starch, carrageenan, carboxymethyl chitin or chitosan, alkylene such as ethylene oxide (C2-C4)
Oxide-added hydroxyalkyl (C2-C
4) chitin or chitosan, low molecular weight chitin or chitosan,
Chitosan salt, sulfated chitin or chitosan, phosphorylated chitin or chitosan, alginic acid or a salt thereof, hyaluronic acid or a salt thereof, chondroitin sulfate or a salt thereof, heparin, ethyl cellulose, methyl cellulose, carboxymethyl cellulose, carboxyethyl cellulose, sodium carboxyethyl cellulose, hydroxyethyl cellulose , Hydroxypropyl cellulose, nitrocellulose, crystalline cellulose, polyvinyl alcohol, polyvinyl methyl ether, polyvinyl pyrrolidone, polyvinyl methacrylate, polyacrylate, polyalkylene oxide such as polyethylene oxide or polypropylene oxide or a crosslinked polymer thereof, carboxyvinyl polymer, Polyethyleneimine and the like.

(10) Surfactant Anionic surfactant (alkyl carboxylate, alkyl sulfonate, alkyl sulfate, alkyl phosphate), cationic surfactant (alkyl amine salt, alkyl quaternary ammonium salt) ), Amphoteric surfactant:
Carboxylic acid type amphoteric surfactant (amino type, betaine type), sulfate ester type amphoteric surfactant, sulfonic acid type amphoteric surfactant, phosphate ester type amphoteric surfactant, nonionic surfactant (ether type nonionic) Surfactants, ether ester nonionic surfactants, ester nonionic surfactants, block polymer nonionic surfactants, nitrogen-containing nonionic surfactants, and other surfactants (natural surfactants) , Derivatives of protein hydrolysates,
Polymer surfactants, surfactants containing titanium and silicon,
Fluorocarbon surfactants).

(11) Various vitamins Vitamin A group: retinol, retinal (vitamin A
1), dehydroretinal (vitamin A2), carotene, lycopene (provitamin A), vitamin B group: thiamine hydrochloride, thiamine sulfate (vitamin B1), riboflavin (vitamin B2), pyridoxine (vitamin B)
6), cyanocobalamin (vitamin B12), folic acids,
Nicotinic acids, pantothenic acids, biotins, choline,
Inositols, vitamin C group: vitamin C acid or a derivative thereof, vitamin D group: ergocalciferol (vitamin D2), cholecalciferol (vitamin D3),
Dihydrotaxelol, vitamin E group: vitamin E or its derivatives, ubiquinones, vitamin K group: phytonadione (vitamin K1), menaquinone (vitamin K
2), menadione (vitamin K3), menadiol (vitamin K4), other essential fatty acids (vitamin F), carnitine, ferulic acid, γ-oryzanol, orotic acid, vitamin Ps (rutin, eriocitrin, hesperidin), vitamin U Such.

(12) Various amino acids Valine, leucine, isoleucine, threonine, methionine, phenylalanine, tryptophan, lysine, glycine, alanine, asparagine, glutamine, serine, cysteine, cystine, tyrosine, proline, hydroxyproline, aspartic acid, glutamic acid , Hydroxylysine, arginine, ornithine, histidine and the like, and their sulfates, phosphates, nitrates, citrates, and amino acid derivatives such as pyrrolidone carboxylic acid.

(13) Various additives derived from plant or animal raw materials These are processed in a conventional manner according to the type and form of the product to be added (for example, pulverization, milling, washing, hydrolysis, Fermentation, purification, pressing, extraction, fractionation, filtration, drying, powdering, granulation, dissolution, sterilization, pH adjustment, deodorization, decolorization, etc. You can choose to serve.

The solvent to be used for the extraction may be selected in consideration of the purpose and type of the product to be provided, the processing to be performed later, and the like. ,Propylene glycol,
It is preferable to use one or a mixture of two or more selected from among 1,3-butylene glycol). However, when the content of the organic solvent is not preferable depending on the application, only water may be used, or ethanol which is easily removed after extraction may be used, and may be used alone or in an arbitrary mixed solution with water. Exploited extract may be used.

In addition, additives derived from plant or animal raw materials are
When applied to systemic or topical external preparations and cosmetics, including protection of skin and hair, moisturizing, improvement of feel and texture,
Giving flexibility, relieving irritation, relieving stress by fragrance, activating cells (preventing cell aging), suppressing inflammation, improving skin and hair quality, preventing and improving rough skin, hair growth, hair growth, hair loss prevention, gloss Application, cleaning effect, relief of fatigue, promotion of blood flow,
In addition to cosmetic effects such as a warm bath effect, effects such as fragrance, deodorization, thickening, preservation, and buffering can be expected.

In foods and drinks, there are healthy and cosmetic effects such as nutritional supplementation, recovery from fatigue, tonicity, cell activation (prevention of cell aging), etc., improvement of taste, provision of color tone, aroma and gloss, stabilization, It can be used for purposes such as thickening and preservation. Furthermore, in addition to this, we expect various cosmetic and pharmacological effects of each raw material known so far, and aim to increase the intended effect by combining them,
Alternatively, it is possible to provide a product that is expected to have a multifunctional effect.

The specific plant (crude) used as a raw material includes
For example, almonds (Hentomo), eye (Aiba), Blue Kazura
(Seifu Fuji), Aoki (Aoki), Aokiri or Kenasia Ogiri
(Otogi), Aotsumuraji (Kibo), Acacia, Akashoma (Akashoma), Akasuguri "fruit", Akagrape, Akaminoki (Logwood), Akamegawiwa (Akabu Kashiwa), Akane
(Akane grass root), Acacia elegans or Jiou (Jihuang), Agi (Awei), Aki larch, Akinire (Royu skin), Aguahe (Omiten palm), Akebi (Kidori), Asa (Ajihito), Malva Asagao or Asagao (Towushi) ), Hydrangea (hydrangea), ashitaba (morning leaf), adzuki (red azuki bean), acerola, asenyaku (asenyaku), acira (shokuyoukanna), anise, abemaki `` fruit '', avocado, ama, amacha (sweet tea), Amachaworu, Amadokoro (Jade bamboo), Amana (Hikarigi), Amaranthus (Amaranthus), Amaranthus (Hymoptera), Senninkoku, Sugimorigeitou, Hosoaoigaito, Aogetoudo, Haribiyu, Amaranthus hippochondriacus, Amigasayuri or Birnamo Alcanna), Argarrobo (cabbage), Altea, Arnica,
Alpinia or red sea bream (Sou-zuku), aloe (lux),
Aloe vera, angelica, apricot or hon apricot (almond jelly), ansokkou (benzoic), Ikakozolina (bile head), epimedium or potato valerian (inyokaku), rush (light heart grass), knotweed (tiger stick root), yew (first place), Strawberry, fig (fructose `` fruit, leaf ''), strawberry (first time), strawberry (winter aoiko), ichiyakuso (one medicinal herb), ginkgo (ginko `` seed, leaf ''), Itohimehagi (enshi), carob, carob bean ( (Telelexi), Inubiyu (Honagainubiyu), Rice `` seed, seed coat '', Inondo `` seed '', Ibuki-kusou-so, nettle, ylang-ylang, iwa-tobacco (iwa-hi-chi-chi), iwahiba or iwa-matsu (makikashiwa), oolong tea, fennel-wheat, wheat (Chibusanoki), Ukiyagara (Mitsuryo), Uguisukagura `` fruit '', Himeuikyo, turmeric (Utsukin), duckweed (buoying), Usubasaishi Or Keirin Herba Asari or Scots. Recently (Hosokarashi), malva sylvestris, marshmallow, Prunella vulgaris (summer hay), Udo or Angelica (羌活, Udo, Tang Udo), Unyadegato (Uncaria, cat's claw), Uva tea, plum
(Umebashi `` seed, pulp ''), Vulgaris ogre, Uwaurushi (Kusaco peach), Unshu mandarin (Chin skin), Estragon, Ezocogi (Ezo Goka), Echinashi (Hosobamurasakibarengiku), Enishida, Enokitake (Enotake mushroom), Ebisugusa or Cassia tora (Keiko), Elcampre, Elderberry `` fruit '', Elemi, Eryngii or Pre-Lotus Erinji, Enju (Gossip, Sophoraceae rice), Ougi or Kibana-ohagi (Ohgi), Ouren (Yoren), Ookarasuuri
(Karokon), giant grove (civil engineering incense), giant clam (self-defense), giant psyllium (forehead child, forehead grass), toucan hazel (haruko), Obanana okera or okera (white jitsu), Obananasasurube (banaba), Obanayashabushi "fruit", Hawthorn or hawthorn (Yamakoko), Ousei (Naruko lily, Kagikurumabanarukoyuri), Oohisasanoyuki or Sasanoyuki, Barley (barley), Greater grass (Grass grass),
Oka, Okazeri (snake bed), Oguruma (turnover), Okra `` fruit '', Panax ginseng or carrot (carrot), Hypericum or Kogomebai perforated or Periwinkle (Brother's cut grass), Odorikosou (intermittent), Onamimomi (blue ears), Onigurumi, Onidokoro or Tokoro or Nagadokoro (Hikai), Oninoyagara (Tianma), Oniyuri or Sasasayuri or Hakatayuri (Yuri), Ononis, Halibut (Hibaha Yu), Ominaeshi (Loose), Oyuko, Dutch mustard (Crasson), Dutch jelly , Dutch honeybee, olives "fruits, seeds, leaves", oregano, orange "fruits, pericarp", calyxio (ripe yellow), cacao "fruits, pericarp,
Seeds '', oysters (persimmon `` leaves ''), kagi kazura (hootshoo), oysters or kantosou (rensensou), cassia, casino
(Kozoumi `` fruits ''), gajutsu (shajutsu), kasiwa (shaki), cascarilla, cascara sagrada, gypsophila, kanikusa (kinsato), kaniwa, kanokoso (valerian grass root), birch or shidare kamba (shirakaba) , Pumpkin, capoknoki "seed", kahoku sansho (shopper), tama (bamboo yellow), chamomile or roman chamomile, chamiyadee (tsukusa), camu cam
(Duck), Karaku salmon, Calla uri or Sinara cucumber (Gourd melon), Callas bishaku (Midsummer), Raspberry, Guarana `` seed '', Karahoo (Popular), Karaya, Karin (Gourd), Garcinia, Kawamidori, Kawara psycho (Koryosai) ,
Japanese white grass), Kawazusha, Kawaratake, Kawaranadeshiko (stone bamboo) or Ezokawaranadeshiko (Qumugi, Quumiko), Kawaran Ginseng (Aokko), Kawamuragi (Inchinko), Kansui (Kansai), Licorice (Lucifera), Kantarasa, Candelilla, canto, canna, raspberry (ezo strawberry, dutch strawberry, shrimp strawberry, pear strawberry, maple strawberry,
(European strawberry), Kiwi `` fruit, leaf '', Kikarasuuri (Ururone), Kikyo (Kikyo, Kikyo root), Chrysanthemum (Chrysanthemum flower), Simakangiku, Daffodilium), Catalpa (Azumino), Rigid japonica (Yotei) Pheasant (Kikomi), Kizuta, Kidachi aloe, Kidachimina, Kina, Kinoki (Shincona, Akakinoki), Quinoa (Quinoa), Kihada (Huangbashi),
Gymnema sylvesta, cabbage, cabbage `` immature fruit '', cucumber, gyoryu (Nishikawayanagi, Ichiyanagi), Kiraja saponaria, Kiraya, Kiranso (gold pea grass), kumquat `` fruit '', betel, kinmizukiki (senzaku grass), guava "Fruit", Guayule, Quercus Infectria
(Gallery), Kukui Nuts, Kukui (Gugi, Kikougi, Kikou Leaves, Skeletal Bark), Kusagi Kazura (Tenmen Winter), Kuzu (Kuzukane),
Camphor tree, gooseberry `` fruit '', ginseng, yellow gardenia, gardenia, kunugi, kupuasu,
Kumazasa, Kumamatsuura (horse whip grass), Clara (bitter butter), cranberry "fruit", chestnut "seed, fruit, astringent skin", curculigo latifolia "fruit", grapefruit "fruit /
`` Leaves '', buckthorn, black squirrel (needs rescue), black blossoms, or crab (extended life grass), cloves (cloves, cloves), gumbinazuna (sekimei, sekimeishi),
Kaigai (Thorndust, Ikutakeho), Celosia (Rooster, Chicken),
Bay laurel, kenashi sartorii rose (Tobukuryo, Yamakiko), gentian, gennoshoko (Old treasured),
Kemponashi (Kigushi), Koukisekikoku, Kishumitsukan
(Koji, Tachibana, Olivenimikan, Fukuromikan,
Sagami Koji, Ponkan, Santara (Tachibana skin)), Koshinbara (Monthly flower), Kouzi mint, Kozo `` fruit '', Kocha (tea), Kouhone (river bone), Kouhon (straw, Kara straw), Koryan, Koryokyo ( Kojiro), cilantro (fruit), coconut (kohuangren), koganebana (yellow gon), lingonberry (koshibachi), coconut palm (fruit), goshyu (goshuyu), goshoichigo (covered bonsai), pepper (pepper), kopaiba balsam , Coffee `` seed, leaves '', kobushi or magnolia (spicy), burdock (burdock, burdock), kobotdur, sesame (sesame), sesame seeds (ginseng), goji (sesame), scallop or binankazura or Matsubusa, wheat (wheat) ),
Rice or rice bran “red bran, white bran”, rice oil, cola acuminata “seed”, cola vera “seed”, fenugreek “fruit”,
Colombo, Konzulango, Kombu, Konjac, Comfrey (Shinbari grass), Sisal (Sisal Asa), Sakisima button or Sinata button or Sinensensou (Eisensen), Sakura (Oshimashima cherry, Yamazakura, Oyamazakura, Edhigashi, Mamezakura, Miyayamazakura, Someiyoshino, Takanezakura, Kasumizakura, Chojizakura, Kohigan, Satozakura, Kanzakura `` leaves, flowers, fruits, bark (cherry bark) ''), cherries, pomegranate, sasa, sasanqua, sagemodaka (sawashari), sweet potato, sugarcane,
Sugar beet, Sun jujube (acid jujube), saffron
(Bamboo safflower, West safflower), Pomelo `` fruit '', Soapwort, Salmonberry `` fruit '', Sarashina-sho (Masahima), Salvia (Sage), Sawagikyo (Yamakona), Sawagurumi (Yamagomo), Sangre degrad (Croton ), Panax ginseng, Panax ginseng (Sax carrot), Sanshuyu (sanshuyu), Sansho (Sansho), Sandzukon (Yamazone), Shea (Karite), Cyano (fruit), Shiitake (Shitake mushroom), Zion ( (Shien), Dictalis, Shikunshi (Kimiko), Perilla or Aodiso or Chirimenzo or Katamamenjiso (Shiyo-leaf, Shiso), Rosewood, Shinanoki, Shinanohonoki, Chinese Forsythia (Forsythia), Shimeji (Hinshimeji, Shakashimeji, Hatakeshimeji, Oshureshimaji) , Honjimeshi, Shimotamogitake), Spiraea, Potato, Peony (Shakuyaku), Shajin (Shasan), Jasmine (Ma Rika),
Jano-beard (Bakumon winter), Gypsophila paniculata, Sku-shamitsu (sand sand, sand compaction), Juzudama, Palm `` fruit '', ginger (ginger), jadean hydrangea (Joyama), shobu
(Irises, iris roots), shojiku `` fruits '', shirakashi `` seed '', white walnuts `` seed '', white adzuki bean (chicken bone), white iris (small iris), white napatsuta `` flower '', white nanten (minamitenmi), shinkonasakushi Rubra, Jingkoge (Mizuka, Mizuka, Shencho), Cinnamon, Cinnammom Cassia (Kihi), Watermelon (watermelon),
Honeysuckle (gold and silver flowers, Shinobi winter), sorrel (acid pattern), swim berry `` fruit '', stevia, strawberry `` fruit '', suzu psycho (Xu Chang Lord), horsetail (question thorn), suberhide (horse dent,
Horse-tooth Kenko), Plum `` fruit '', Pinus densiflora `` cones '', larch larch, eucalypt, corn walnut, eucalypt, dandelion, horse chestnut (malonie), eucalypt `` fruit '', eucalypt, (Elder), Aesculus serrata (Juniper, Juniper), Achillea millefolium (Mirfoils), Alaska roses, Alaska aurora,
Mistletoe, Common mint or Common mint, Horseradish, Sekisho (stone iris), Red pepper
(Ishi-masu), Cedron (Bowshu-boku), Gentle mallow, Hirohasenega, Senega, Seri, Celery, Senkyuu (Kawakyuu), Senshinren (Shinshinren), Sendan, Senburi (drug), Senna `` Fruits, leaves '', Senninsou (Large) Tate), souka (grass), buckwheat "seed", soybean potato, rhubarb (daisou), radish, soybean, daidai (orange peel, kikomi), takasaburo (dry lotus), takatodai (daiseki), takawarabi ),
Dark sweet cherry "fruit", hollyhock, hollyhock (thyme, morika), hollyhock (hikari), hollyhock, tamarind "seed", onion, tamashiba
(Spicy), Tara tree `` fruits, leaves, root bark '', tarwi, tanjin (dansin), dandelion (Kabukohide) or white dandelion or moko dandelion, dammar, cherry `` fruit '', tigaya `` fruit, root, bud '', chiksetsu Carrots (bamboo ginseng), chicory, chancapiedra (fat bean ginseng), daffodil (daisies), daffodil (buoy), artemisia (aussin), choreimaitake (horingu), chorogi,
Tsukimiso, Tsukuritake (mushroom), Camellia, Camellia, Tsumekusa (lacquer lacustrine), Tsumukusa (duckling grass), Tsuruazuki (red azuki bean), Tsurukudami (Hanshukara), Tsuruna (Banju),
Carrot (four-leaf ginseng), camellia, deiko, teuchigurumi, duberry `` fruit '', tengusa, tencha (tencha),
Tendai-yaku (crowd drug), touga (winter gourd), touokazuzura, pepper (bansho), touki (toki), tokinsenka
(Marigold), cornflower (river cut), corn or corn hair (nanban hair), horned rice mochi (femako),
Gentian or Korean gentian (dragon gall), horsetail
(Pirate), dokudami (jujutsu), radish (root), toshishi or beetle or pear, and eucommia (tochu `` bark,
`` Leaves, roots ''), ash (qin peel), tomato, tragacanth, triacanthos `` seed '', tormentilla, dronoki, troloioi, Niseria berry `` fruit '', potato or yam (herbal medicine), nagikadada (butcher bloom), naginata koju, Nazuna, oilseed rape, oilseed bean or sword bean (sword bean), jujube, jujube (daijutsu), nanawaibara
(Kanekurako), Navena (intermittent), Nameko, Narco lily (Yoshimi),
Peanut (peanut), Nanten (Minami Tenmi), Namban Karamushi (ramie), Nigaki (bitter tree), Japanese Artemisia (bitter), Nikuzuku, Kay or Nikkei or Ceylon Nikkei or Yabnikkei (cinnamon bark) or Keishi (Keishi), Chinese chive (Niriko), elderberry (bone-bearing tree `` fruit, flower, stem, leaf ''), garlic (garlic), nurde (five times), leek, nemoki or neb or nebi or nemuriki or digokbana (health), thistle (Oji) , Noibara (Fruit), Yarrow, Soybean (Maeko), Nobara, Nomomo, Palm, Pineapple "fruit", Hibiscus
(Bussouge, FULIN BUSOUGE, Roselle), Hi-Gindo, Hakamauraboshi (bone crushing), Hakusen (ringworm skin),
Huckleberry `` fruit '', chickweed (reproducible), hazel (haruko), hashidokoro (roth root), basil, lotus (lotus, lotus, lotus root), parsley (Netherland jelly), hamkamugi, batata, hachiku or matake (bamboo-boiled) , Patchouli, mint (light load, light load leaf), adlay (yokuinin), hanasuge (chimbo), banana, hanaminta, hanabishi (siturishi, shishitsuri), vanilla bins, papaya, japonicus (rat malt),
Pahalobobo, hub `` whole grass, stem, leaf '', paprika, hamago or honeysuckle (vine thorn), hamasuge (kosuke), hamabishi (shikoriko), hamanas (maikai flower), hamabafu (beach storm), hamamelis, rose (Rose), agaric (aragaric, agaricus agaricus, usukimori no kasa), haran, pariurus (Prunus avium), parietalia,
Balsamina (Tsurureishi, Nigauri), Harunile (Yellow, Yuhakuhide, Yuba), Harindou, Handaikai (Matsudaikai), Breadfruit, Hiougi (sun dried), Lycopodium carrot
(Party Party), Pu'er Tea (Pu-cha), Pecan Nut, Amaryllidaceae (Shirubi, Toranshasha), Hishi (Ryomi), Pistachio, Beet, Hitotsuba (Stone Reed), Hitotsubeniishida, Hinata no Kozuchi (Cow Knee) ), Cypress, Hiba, Castor, Sunflower, Bell Pepper, Himeuzu (Tenoi), Himegama (Kaba), Himematsutake
(Kawariharatake, Hiromatsutake), Pimenta `` fruit '',
Juniper, juniper, hyouyu `` fruit '', below-flower, hiroha okinagusa (bakuin), loquat `` fruit, leaf,
Stalks '', betel wax (large clothing skin, areca locust), sugar beetle (southern rattan), butterflies, coltsfoot (populations of winter flowers, coppice winter leaves), fujibakama (orchids), fujimame beans (flat beans), grapes `` fruits, peels, seeds, leaves '' , Beech, Fuyumushinatsukutake (Cordyceps), Brazilian liquorice, Brazilian carrot, Blackcurrant "fruit", Blackberry, Plum "fruit", Flucellaria, Blueberry (Prunus americana), Prune, Blonde psyllium, Bundou (green bean) , Hazelnut, loofah, safflower (safflower), henneken, belladonna, berry `` fruit '', Peruvian berg, benceisou or duckweed (Keiten), boysenberry `` fruit '', broom beetle or elderweed or endow or hakigi kokia (ground silk) , Balsam (Hosen, acute offspring, osteophyte), spinach, boufu (windbreak), spinach, ho Suzuki (Toro root), Magnolia obovata (KazuAtsushiBoku, Park), blur (quince), Hosobanaokera (Aoiokera), e buckwheat Roh Kirin Saw (Keiten thirty-seven), Hosobabarengiku, linden (菩醍 trees), button ( "flower,
Leaf, stem, bark "), buttonpi (peony bark), hop, jojoba, bordeaux, white berry" fruit ", hon-oniku
(Nikuju Ryo, Daigei), Hongsek-koku (iron bark stone, sparrow mountain stone mascara), mysurutennansha (tennan star), maitake (maitake), ephedra (mao), maca, macadamia nut, macri
(Sea grass), Magwa (mulberry white bark `` bark, leaves ''), magnolia
Splengeri, Mashua (Tamanousenharen, Kyukonkinrenka), Matatabi (Kiten Tate), Matsukasa, Pine `` leaves, bark, roots '', Matsuhod (Bukuryo), Matico (Cordon Sillo), Maryoram (Hanahakka), Malvanozadine (Bitter ), Mulberry "fruit", quince, mango,
Mangosteen, Mansagna (Andesca beetle), Mansuru walnut, Mandarin `` Fruit '', Mannentake (Lingzhi), Pheasant (Kikomi `` Fruit ''), Mishima saiko (Saiko), Mizuobako or Mizuasagao (Ryu tongoshi), Mizokoshi Lotus), misohagi (senkakuna), beet willow or elder willow
(Henshin), honeysuckle, honeysuckle, green peppermint, mimosa,
Ginger, miracle fruit `` fruit '', myrrh, mirobaran, wheat waragiku, mugwort (tree geun), mukunoki, mukuroji (extended life skin), munya, murasaki (purple root), murasakisikibu or omurasakishikibu (purple bead), murasaki maize, murasaki natsufuji Kunming chicken blood wisteria), swordfish (mother grass), scallop, melaleuca, melissa, melillot,
Melon "fruit", sagebrush, moso bamboo, moje
(Keikoboku), Mokko (Kiko), Japanese Maple,
Peach (peach `` leaves, seeds, flowers, fruits ''), sprouts, morello cherries `` fruits '', moroheiya (burlap), yakawamurasakiimo, yakuchi (masuti), cornflower (cornflower), cornflower mint, yacon, yashabushi ( Yashabushi or Himeyashabushi or Obayayashabushi `` fruit, peel, ears '', yachiyanagi, yatsude (octagonal metal plate), mistletoe (parasitic willow), willow (kawayanagi, tachinyanagi, weeping willow, red eye willow, pussy willow, inuyanagiunyagi, yinagoyanagina , Yamayama willow, palm, yamayanagi, obanyanagi, tyrichkinuyanagi, foxwood willow, bonsai), yanagitade `` leaves, stems '', yabugarashi, yabukouji (purple gold beef), yabu cigarette (tsuruisui, tenmeisei),
Pokeweed (commercial land), alder (yamaharu), yamamo (yang plum skin), sagebrush, eucalyptus, yukinoshita (tiger ear grass),
Yucca or flevifolia, Yuzu `` fruit '', lily, royal grass, mugwort (Aiba), ligan (Rainuma), lime `` fruit '', rye, lacanca `` fruit '', raspberry `` leaf,
Fruits, Latania (Crameria), Rakkyo or Shallot (Shiroi), Lavender, Longan (Longan flesh), Agave (Aono agave, Fukurin Agave), Ryokucha (green tea), Apple `` Fruits, seeds,
`` Leaves, roots '', gentian, rubus or suavisimus,
Ganoderma litchi (Lichi, Lichi nucleus), lettuce (Chisha), red currant "fruit", lemon "fruit", lemongrass, forsythia or Chinese forsythia (forsythia), astragalus, coconut palm, lokon (reed, azuki), loganberry Examples include "fruit", rosemary (mannen wax), rose hip (nobara), wasabi, and valerobium (chiyu).

Further, other seawaters, for example, seawater salt, dried seawater, inorganic salts obtained from the Dead Sea or the Atlantic or Pacific Ocean (sodium chloride, magnesium chloride, potassium chloride, etc.), sea mud or mud (fango) Species, for example, sea mud or mud of various places such as Italian Fango, German Fango, Eifel Fango, Freiburg Fango, etc. (Ingredients:
Silicon dioxide, titanium dioxide, aluminum oxide, iron oxide, manganese oxide, sodium oxide, potassium oxide, magnesium oxide, calcium oxide, strontium oxide, sodium, potassium, magnesium, calcium, chromium, iron, copper, nickel, zinc, lead, manganese,
Arsenic, water), Shotoku stone.

Examples of the seaweeds include seaweeds [green algae: Chlorella vulgaris, Chlorella pyrenoidsa, Chlorella ellipsoidia, Aonori (Usubaonori, Susiaonori, Hiraaonori, Bowaoonori, Hosoedaoonori), and seaweed [brown alga: Kombu algae: , Resilicon b, hosomekobu, mishitoshibu), seaweed, hirome, blue seaweed, giant kelp (macrocystis pilifera, macrocystis integrifolia, neocitys luetokeana), hijiki, hibamata), seaweed [red alga: hijirimen, maxa ( Tengsa),
Hirakusa, Omikusa, Obakusa, Katao Bakusa, Yatabegusa, Yuikiri, Shimanegusa, Tosakanori, Togekirinsai, Akumasakirinsai, Kirinsai, Zyakushinkirinsai, Tsunomata, Obatsunomata, Tochaka , Ibotsunomata, Yaleus Banori, Kagius Banori,
Sujiusbanori, haiusbanori, akaminominori] and the like.

Also, other algae, for example, green algae (Chlamydomonas: Chlamydomonas, Akayukimo, Dunaliella: Dunaliella, Chlorococcus: Chlorococcus, Kwanomimo: Kwanomimo, Volvox: Ohikawawari, Volbox, Palmera, Yotsumemo, Spirogyra: Hizaori, Spirogyra, Tulsimidro, Hibimidoro: Hibimidoro, Aosa: Anaoasa, Amiosa, Nagaosa, Kawanori: Kawanori,
Genus Fricciella, genus genus: medusa, asiaticum gutta, kawashiogusa, marimo, baronia: tamagobaronia, tamabaronia, tamagata: tamagatamo, iwata: husaiwata, surichogita, heraiwata, kurokita, kurokita, kurokita Sakibuchimil, Nagamir, Hiramil, and Casanori:
Casanori, Jusmo: Fusuzumo, Tamazumi,
Species of the genus Mizudzumo, Genus Genus, Genus Colecaet, Genus Genus genus, Species of the genus Cyperaceae: Species of the genus Cyperaceae, the genus of the spider genus;

Cyanobacteria (Genus Suicide: Suizenori, Aomori, Nostoc: Kawatake, Ishikurage,
(Hassay, Yuremo genus, Racenmo (Spirulina) genus: Spirulina, Trichodesmium (Aiacacio) genus, etc.).

Brown algae (Piraella spp .: Piraella spp., Spirogyra spp.
Genus Isogawara: Isogawara, Kuroshira Genus: Gunsenkurogashira, Kashirazaki Genus: Kashirazaki, Muchimo Genus: Muchimo, Hiramutimo, Kebelligsa, Amidixa Genus: Amidigsa, Sakibiroamiji, Sanadagusa: Sanadagusa, Fukurinamiji, Common Genus Artemisia spp.
Genus genus: genus pine, genus genus: genus genus: genus genus, genus okinawa, genus okinawazuku, genus phlebosum, genus phlebosum, genus phlebosum: genus futomozuku, genus genus moss: genus genus: genus kuromo, genus moss, genus genus Ishige, Irolo, Icmegasa: Ichimegasa, Keyari: Keyari, Umibos: Umibos, Urushigusa: Ursigusa,
Betula serrata, Tobacco moss, Laminaria spp. Genus Kagomenori: Kagomenori, Muraridori: Murachidori, Shakusugusa: Sharks
Genus Genus: Genus Genus, Genus Genus: Genus Genus: Genus Genus, Genus Kayamonori, Genus Genus: Genus Genus: Genus Filiformis, Genus Turmo: Genus Tsurumo, Genus Anana: Genus Anastasia, Genus Suzume: Genus Musicum, Genus Missiscoma, Genus L. , Oni-kombu, Gohei-kombu, Naga-kombu, Pea-kombu, Ochimitsu-kombu, Toro-kombu genus: Toro-kombu, Antokume genus: Antokume, Kajime genus: Kajime, Tsuruarame, Kurome, Kikuishicombu genus: Kikuishikombu, Nejirekombu: Nekorecome genus, Kuroshimae : Nekoshikambu,
Alame: Alame, Ainuwakame: Ainuwakame, Chigaiso, Oniwakameezoishige: Ezoishige, Yabanemoku: Yanemoku, Rapamoku: Rapamoku, Jiromoku: Uganomok, Jiromoku, Hiemomoku, Hokumoku, Tamamomoku, Tamamomoku Akamoku, Shidamoku, Hondawara, Nejimoku, Narasamo, Mametarawara, Tatsukuri, Yasumatamoku, Umitrano, Oobamoku, Fushizushimoku, Hahakimoku, Togemoku, Jolemoku, Saw-moku, Obanoki-mimoku, Genus genus:
Bulukimo, genus cyno (Kayamonoli etc.).

Red algae (Russula genus: Rush genus, Funorinoshiki, Amanori genus: Asakusanori, Susabinori,
Genus Upirinori, Onimanori, Tasa, Filitasa, Benitasa, Rhodocorton: Milnoveni, Akebonomozuku: Akebonomozuku, Konahada: Haikonahada, Yogorekonahada, Aokonahada, Sea Species: Acer genus, Acer genus : Larch, Fusanori: Fusanori, Nisefusanori: Nisefusanori,
Sodegarami: Sodegarami, rattles: rattle, rattle rattle, hirohatamatamaki genus: hirohatamaitadaki, tamamaidaki genus: tamaitadaki, kagikenori genus: kaginori, kakenenori, tengusa: himetenugosa, haitenugosa, haitenugosa, haitenugusaugou, haitenuganugou, haitenuganugou, haitenugusaugou Genus: hibiroudo, himehibiroudo,
Genus Isommedogi: Genus Isomomedo, Genus genus: Genus medusa, Ryumonsou: Ryumonsou, Hera Ryumon, Nisekarekususa: Genus Nisekaregusa, Okitsubara: Obaokitsubara, Akaba: Akaba, Malvaacaba, Naminohana genus
Naminohana, coral genus: rattle, mushroom, shiogosagoromo, iwanokawa: ezukiiwanokawa, kainokawa: kainokawa, kaninote: kaninote, coral genus: coral, coral, mosquito mosquito , Tambanori, slippery,
Genus Isonohana: Nuracusa, Cronulla, Stinging genus, Hirakintoki: Hirakintoki, Matagawa: Matabou, Kintoki: Chabokintoki, Kintoki, Matsunori, Komenori, Tosakamatsu, Aedes pine, Kakraitus: Genus Odonata, Genus Larva Genus Nagaobane, Funori: Hanafunori, Fukuronori, Makuhnori, Karenikusa: Kalexigusa, Tosakamomoki: Hosobanotokamodoki, Hirohanotosakamakiki, Yatsudegatomodoka, Kurosakacamodoki, Nezashinodoka, Nezashinotokada : Ezotosaka, Tsukasanori: Enashikarimenia, Otsukasanori, Hanagatakarimenia, Honooka: Hounoo, Hikagenoito: Hikagenoito, Usuginu, Nikuhono: Nikuho Noo, Benisunago genera: Benisunago, Susukakebeni genera: Susukakebeni, Okamuragusa genera:
Yamadakusa, Mirin genus: Mirin, Hosobamilin, Tosakanori genus: Kikutosaka, Ezonameshi: Ezonameshi, Isomokka genus: Isomocca, Yukari genus: Yukari, Hosoyukari, Ibaranori genus: Ibaranori, Saidaibara, Tachiibara, Kagiibanodan, Kijinotho genus Isanthus, Atsubanori: Atsubanori,
Ogonori: Ogonori, Tsurushiramo, Shiramo, Ogogonori, Mizookonori, Kabanori, Tengusamodoki: Hachijotengusamodoki, Fushikrenori: Fushikenori, Namiiwatake: Namiiwatake, Spiraea:
Sponge and genus: ssp.
Genus: crocodile, crocodile, crocodile, lotus spp .: lotus spp. The genus Taogosou: Taoyanagisou, Hanasakura, Shirotsunagi: Skullconi, Shikokonori, Hananoeda: Hanaeda, Hiratagoat: Hiratagoat, Darusu: Dars, Masagoshibari, Anadars, Weedbugsa: Uebaguni, Benifukunori
Species of sarcophagi: sarcophagia, scorpion, scorpion, scorpion genus: syllabus, smelt, ssp. Family: Habutaenori, Konohanori, Suzushironori, Usbeni genus: Usbeni, Hasuginu: Hasujiginu, Nagakonohanori: Nagakonohanori, Suzuginu: Suzuginu, Abasibaginu, Hyusbanori: Kagusubanori, Jauresubanoli, Jaureusubanoli, Jaureusubanori, Jaureusubanoli
Genus Ayanishi: Genus Ayanishi, Genus Ayaginu: Genus Ayaginu, Genus Dassia: Enashidazia, Genus Shimadagi: Genus Isohagi, Genus Shimadada, Genus Dazimodoki: Genus Dazimomodoki, Genus Itogusa: Moletogusa, Genus Genus: Makuri, Yanagina, Hana, Rana Salix var. Genus Isomegusa: Isomegusa, Suginashigusa: Suginashigusa, Isobashi Genus: Isobashi, Fujimatsumo: Fujimatsumo, Sawweed: Mushroom Rihiba, Kawamozuku genera: Kawamozuku, Aokawamozuku, Himekawamozuku, Ideyukogome genera: Ideyukogome, Okichimozuku genera: Okichimozuku,
Genus genus, genus chinorimo: chinorimo, genus thysinori: chisinori).

The axle algae (Charus spider, Shiratamamo,
Hossiturimo: Hossiturimo, Lychnotanus genus, Hessian moss: Himejirasamo, Chaboshiramo, Tripera, etc., and yellow algae (Hikarimo: Hikarimo etc.).

Materials derived from animal raw materials include cockscomb extract, bovine or human placenta extract, swine or bovine stomach, duodenum or intestinal extract or decomposed product thereof, and swine or bovine spleen extract. Product or its degradation product, extract of pig or cow brain tissue, water-soluble collagen, collagen derivative such as acylated collagen, collagen hydrolyzate, elastin, elastin hydrolyzate, water-soluble elastin derivative, keratin and its decomposition product Or a derivative thereof, a silk protein and its degradation product or a derivative thereof, a pig or bovine blood cell protein degradation product (globin peptide), a pig or bovine hemoglobin degradation product (hemin, hematin, heme, protohem, heme iron, etc.),
Cow milk, casein and its decomposition products or their derivatives, skim milk powder and its decomposition products or their derivatives, lactoferrin or its decomposition products, chicken egg components, fish meat decomposition products and the like.

(14) Microbial culture metabolite Yeast metabolite, yeast extract, natto metabolite, natto extract, rice ferment extract, rice bran ferment extract, euglena extract, lactic acid fermentation of raw milk or skim milk powder, and trehalose Or a derivative thereof.

(15) α-Hydroxy acids glycolic acid, citric acid, malic acid, tartaric acid, lactic acid and the like.

(16) Inorganic pigments Silicic anhydride, magnesium silicate, talc, kaolin,
Bentonite, mica, titanium mica, bismuth oxychloride, zirconium oxide, magnesium oxide, zinc oxide,
Titanium oxide, calcium carbonate, magnesium carbonate, yellow iron oxide, red iron oxide, black iron oxide, gunjou, chromium oxide,
Chromium hydroxide, carbon black, calamine, etc.

(17) UV absorber / blocker Benzophenone derivatives (2-hydroxy-4-methoxybenzophenone, 2-hydroxy-4-methoxybenzophenone-
5-sulfonic acid, 2-hydroxy-4-methoxybenzophenone-5-sulfonic acid sodium salt, dihydroxydimethoxybenzophenone, dihydroxydimethoxybenzophenone-sodium sulfonate, 2,4-dihydroxybenzophenone, tetrahydroxybenzophenone, etc.), p-
Aminobenzoic acid derivatives (such as paraaminobenzoic acid, ethyl paraaminobenzoate, glyceryl paraaminobenzoate, amyl paradimethylaminobenzoate, octyl paradimethylaminobenzoate), and methoxycinnamic acid derivatives (ethyl paramethoxycinnamate, isopropyl paramethoxycinnamate, Octyl paramethoxycinnamate, paramethoxycinnamic acid
2-ethoxyethyl, sodium paramethoxycinnamate, potassium paramethoxycinnamate, monodiparamethoxycinnamate
Glyceryl-2-ethylhexanoate), salicylic acid derivatives (octyl salicylate, salicylphenyl, homomenthyl salicylate, dipropylene glycol salicylate, ethylene glycol salicylate, myristyl salicylate, methyl salicylate, etc.), anthranilic acid derivatives (methyl anthranilate, etc.), urocanin Acid derivatives (such as urocanic acid and ethyl urocanate), coumarin derivatives, amino acid compounds, benzotriazole derivatives, tetrazole derivatives, imidazoline derivatives, pyrimidine derivatives, dioxane derivatives, camphor derivatives, furan derivatives, pyrone derivatives, nucleic acid derivatives, allantoin derivatives, Nicotinic acid derivatives, vitamin B6 derivatives, umbelliferone, esculin, benzyl cinnamate, sinoxate, oxybenzone, diamine Kishibenzon, Okutabenzon, sulisobenzone, benzo resorcinol, arbutin, guaiazulene, shikonin, baicalin, baicalein, berberine, Neo Heliopan, ESKA roll,
Zinc oxide, talc, kaolin, etc.

(18) Whitening agent p-aminobenzoic acid derivative, salicylic acid derivative, anthranilic acid derivative, coumarin derivative, amino acid compound,
Benzotriazole derivatives, tetrazole derivatives, imidazoline derivatives, pyrimidine derivatives, dioxane derivatives, camphor derivatives, furan derivatives, pyrone derivatives,
Nucleic acid derivatives, allantoin derivatives, nicotinic acid derivatives,
Vitamin C or its derivatives (vitamin C phosphate magnesium salt, vitamin C glucoside, etc.), vitamin E or its derivatives, kojic acid or its derivatives, oxybenzone, benzophenone, arbutin, guaiazulene, shikonin, baicalin, baicalein, berberine, placenta extract , Ellagic acid, lucinol and so on.

(19) Tyrosinase activity inhibitor Vitamin C or a derivative thereof (such as magnesium phosphate magnesium phosphate of vitamin C or vitamin C glucoside), hydroquinone or a derivative thereof (such as hydroquinone benzyl ether), kojic acid or a derivative thereof, vitamin E or Derivatives thereof, N-acetyltyrosine or derivatives thereof, glutathione, hydrogen peroxide, zinc peroxide, placental extract, ellagic acid, arbutin, rucinol, silk extract, plant extract (chamomile, mulberry, corn, waremokou, clara, mugwort, Honeysuckle, yellowfin, amberjack, matsuhodo, adlay, dragonflies, hops, hawthorn, eucalyptus, achillea millefolium, althea, keihi, mankeishi, hamamelis, yamaguwa, enmeisou, bellflower, toshishi, seizome, sun dried, mao, senkyu Dokkatsu, Psycho, storm, littoralis, Scutellaria, peony bark, peony, cranesbill, kudzu root, licorice, Fushi aloe, Cimicifuga, safflower, green tea, black tea, Ali elixir), and the like.

(20) Melanin pigment reducing / decomposing substance: phenylmercury hexachlorophene, mercuric oxide, mercuric chloride, hydrogen peroxide, zinc peroxide, hydroquinone or a derivative thereof (hydroquinone benzyl ether) and the like.

(21) Turnover promoting action / cell activator hydroquinone, lactic acid bacteria extract, placenta extract, reishi extract, vitamin A, vitamin E, allantoin, spleen extract, thymus extract, yeast extract, fermented milk extract, plant extract (Aloe, Ogon, horsetail, gentian, burdock,
Sicon, carrot, hamamelis, hop, yokunin,
Odrich, Assemble, Touki, Calendula officinalis, Amacha, Hypericum perforatum, Cucumber, Periwinkle,
Rosemary, parsley).

(22) Astringent succinic acid, allantoin, zinc chloride, zinc sulfate, zinc oxide, calamine, zinc p-phenolsulfonate, potassium aluminum sulfate, resorcinol, ferric chloride, tannic acid (including catechin compound) Such.

(23) Active oxygen scavenger SOD, catalase, glutathione peroxidase and the like.

(24) Antioxidants Vitamin C or a salt thereof, stearic acid ester, vitamin E or a derivative thereof, nordihydroguaselethenoic acid, butylhydroxytoluene (BHT), butylhydroxyanisole (BHA), hydroxytyrosol, Parahydroxyanisole, propyl gallate, sesamol,
Sesamolin, gossypol, etc.

(25) Lipid peroxide production inhibitor β-carotene, plant extract (cultured sesame cells, amateur,
Hypericum, Hamamelis, Clove, Melissa, Emmeso, Birch, Sage, Rosemary, Minami Amami,
Ages, ginkgo, green tea) etc.

(26) Anti-inflammatory agent Ictamole, indomethacin, kaolin, salicylic acid, sodium salicylate, methyl salicylate, acetylsalicylic acid, diphenhydramine hydrochloride, d-camphor,
dl-camphor, hydrocortisone, guaiazulene, camazulene, chlorpheniramine maleate, glycyrrhizic acid or a salt thereof, glycyrrhetinic acid or a salt thereof, licorice extract, sicon extract, age extract and the like.

(27) Antibacterial / bactericidal / disinfectant Acrynol, sulfur, calcium gluconate, chlorhexidine gluconate, sulfamine, mercurochrome, lactoferrin or its hydrolyzate, alkyl diaminoethyl glycine chloride solution, triclosan, sodium hypochlorite, Chloramine T, salad powder, iodine compound,
Iodoform, sorbic acid or a salt thereof, salicylic acid, dehydroacetic acid, parahydroxybenzoic acid esters, undecylenic acid, thiamine lauryl sulfate, thiamine lauryl nitrate, phenol, cresol, p-chlorophenol, p-chloro-m-xylenol, p-chloro-m-cresol, thymol, phenethyl alcohol, o-phenylphenol, irgasan CH3565, halocarban, hexachlorophen, chlorohexidine, ethanol, methanol, isopropyl alcohol, benzyl alcohol, ethylene glycol, propylene glycol, phenoxyethanol, chlorobutanol, Isopropyl methyl phenol, nonionic surfactants (polyoxyethylene lauryl ether, polyoxyethylene nonyl phenyl ether, polyoxyethylene Octylphenyl ether, etc.), amphoteric surfactant, anionic surfactant (sodium lauryl sulfate, lauroyl sarcosine potassium, etc.), cationic surfactant (cetyltrimethylammonium bromide, benzalkonium chloride, benzethonium chloride, methylrosaniline chloride), formaldehyde , Hexamine, brilliant green, malachite green,
Crystal Violet, Jamal, Photosensitizer 101
No. 201, Photosensitizer No. 401, N-long-chain acyl basic amino acid derivatives and their acid addition salts, zinc oxide, hinokitiol, kudin and the like.

(28) Humidifier Glycerin, propylene glycol, 1,3-butylene glycol, hyaluronic acid or its salt, polyethylene glycol, chondroitin sulfate or its salt, water-soluble chitin or chitosan derivative, pyrrolidone carboxylic acid or its salt, lactic acid Sodium, Mini Sasanishiki extract, Bacillus natto metabolite, Natto extract, etc.

(29) Elastase activity inhibitor diisopropyl fluorophosphate, plant extracts (Ougon, Hypericum perforatum, Clara, mulberry leaves, calyx, gennoshoko, comfrey, sage, Atlantic elderberry, bollige, buttonpi), seaweed extract and the like.

(30) Hair preparations Selenium disulfide, alkylisoquinolinium bromide solution, zinc pyrithione, biphenamine, thianthol, castal tincture, ginger tincture, capsicum tincture, quinine hydrochloride, strong aqueous ammonia, potassium bromate, bromate Sodium, thioglycolic acid and the like.

(31) Antiandrogens Estrogen (eg, estrone, estradiol, ethinylestradiol), isoflavones, oxendrone, etc.

(32) Peripheral vascular blood flow promoter Vitamin E or a derivative thereof, assembly extract, garlic extract, carrot extract, aloe extract, gentian extract, touki extract, cepharanthin, carpronium chloride, minoxidil and the like.

(33) Topical stimulants Pepper tincture, vanylamide nonylate, tincture tincture, tincture tincture, peppermint oil, l-menthol, camphor, benzyl nicotinate and the like.

(34) Metabolic activators Photosensitizer No. 301, hinokitiol, pantothenic acid or derivatives thereof, allantoin, placenta extract, biotin, glyceride pentadecanoate, and the like.

(35) Antiseborrheic agents Pyridoxine or its derivatives, sulfur, vitamin B6 and the like.

(36) Keratolytic agent Resorcin, salicylic acid, lactic acid and the like.

(37) Oxidizing agent Hydrogen peroxide solution, sodium persulfate, ammonium persulfate, sodium perborate, urea peroxide, sodium percarbonate, sodium tripolyphosphate, sodium bromate, potassium bromate, pyrroline peroxide Sodium silicate, sodium orthophosphate, sodium silicate hydrogen peroxide adduct, sodium sulfate sodium chloride hydrogen peroxide adduct, β-tyrosinase enzyme solution, mushroom extract, etc.

(38) Hair remover Strontium sulfate, sodium sulfide, barium sulfide,
Inorganic reducing agents such as calcium sulfide; thioglycolic acid or salts thereof (calcium thioglycolate, sodium thioglycolate, lithium thioglycolate, magnesium thioglycolate, strontium thioglycolate) and the like.

(39) Hair swelling agent Ethanolamine, urea, guanidine and the like.

(40) Dyes 5-aminoorthocresol, 2-amino-4-nitrophenol, 2-amino-5-nitrophenol, 1-amino-4-methylaminoanthraquinone, 3,3'-iminodiphenol ,
2,4-diaminophenoxyethanol hydrochloride, 2,4-diaminophenol hydrochloride, toluene-2,5-diamine hydrochloride, nitroparaphenylenediamine hydrochloride, paraphenylenediamine hydrochloride, N-phenylparaphenylenediamine hydrochloride, metaphenylenediamine hydrochloride, ortho Aminophenol, N-phenylparaphenylenediamine acetate, 1,4-diaminoanthraquinone, 2,6-diaminopyridine, 1,5-dihydroxynaphthalene, toluene-2,5-diamine, toluene-3,4-
Diamine, nitroparaphenylenediamine, paraaminophenol, paranitroorthophenylenediamine, paraphenylenediamine, paramethylaminophenol,
Picramic acid, sodium picramate, N, N'-bis (4-aminophenyl) -2,5-diamino-1,4-quinonediimine, 5- (2-hydroxyethylamino) -2-methylphenol, N-phenyl Paraphenylenediamine, metaaminophenol, metaphenylenediamine, 5-aminoorthocresol sulfate, 2-amino-5-nitrophenol sulfate,
Orthoaminophenol sulfate, orthochloroparaphenylenediamine sulfate, 4,4'-diaminodiphenylamine sulfate, 2,4-diaminophenol sulfate, toluene-2,5-sulfate
Diamine, nitroparaphenylenediamine sulfate, paraaminophenol sulfate, paranitroorthophenylenediamine sulfate, paranitrometaphenylenediamine sulfate, paraphenylenediamine sulfate, paramethylaminophenol sulfate, metaaminophenol sulfate, metaphenylenediamine sulfate, catechol, diphenylamine , Α-naphthol, hydroquinone, pyrogallol, phloroglucin, gallic acid, resorcin, tannic acid, 2-hydroxy
Sodium 5-5-nitro-2 ', 4'-diaminoazobenzene-5'-sulfonate, hematein and the like.

(41) Flavors Natural animal flavors such as musk, civet, castorium, ambergris, anise essential oil, angelica essential oil, ylang ylang essential oil, iris essential oil, fennel essential oil, orange essential oil, cananga essential oil, caraway essential oil, cardamom essential oil, Guaiac wood essential oil, cumin essential oil, black letter essential oil, cinnamon essential oil, cinnamon essential oil, geranium essential oil, copaiba balsam essential oil, coriandel essential oil, perilla essential oil, cedarwood essential oil, citronella essential oil, jasmine essential oil, ginger grass essential oil, cedar essential oil, spearmint essential oil, western Mentha essential oil, Great Fengxiang essential oil, Tuberose essential oil, T-shape essential oil, Orange flower essential oil, Winter green essential oil, Truval sam essential oil, Batturi essential oil, Rose essential oil, Palmarosa essential oil, Cypress essential oil, Hiba essential oil,
Sandalwood essential oil, Petit glen essential oil, Bay essential oil, Vetiva essential oil, Bergamot essential oil, Peruvian balsam essential oil, Boad rose essential oil, Camphor essential oil, Mandarin essential oil, Eucalyptus essential oil, Lime essential oil, Lavender essential oil, Linaloe essential oil, Lemon grass essential oil, Lemon essential oil, Rosemary Vegetable flavors such as essential oils and Japanese peppermint essential oils, and other synthetic flavors.

(42) Dyes / Colorants Red cabbage dye, red rice dye, madder dye, anato dye, squid dye, turmeric dye, ende dye, krill dye, persimmon dye, caramel, gold, silver, gardenia dye, corn dye , Onion pigment, tamarind pigment, spirulina pigment, buckwheat whole plant pigment, cherry pigment, laver pigment, hibiscus pigment, grape juice pigment, marigold pigment, purple potato pigment, purple yam pigment, lac pigment, rutin, etc.

In addition, humectants, hormones, sequestering agents, pH adjusters, chelating agents, antiseptic / antibacterial agents, fresheners, stabilizers, emulsifiers, animal and plant proteins and their decomposed products, animal and vegetable Vegetable polysaccharides and their degradation products, animal and vegetable glycoproteins and their degradation products, blood flow promoters, anti-inflammatory agents / antiallergic agents, cell activators, keratolytic agents, wound treatment agents, foaming agents,
Examples include thickeners, oral agents, deodorants / deodorants, bitters, seasonings, enzymes, and the like. When used in combination therewith, various additive and synergistic effects can be expected.

The active oxygen scavenger, lipid peroxide production inhibitor, antiallergic agent and cosmetic composition of the present invention can be in any dosage form, including capsules, powders, granules, solids, liquids, gels, bubbles, It can be used in pharmaceuticals such as emulsions, creams, ointments and sheets, quasi-drugs, and cosmetics for skin and hair.

Specifically, for example, external preparations, basic cosmetics such as lotions, emulsions, creams, ointments, lotions, oils, packs, facial cleansers and skin cleansers, depilatory agents, depilatory agents, aftershave lotions , Pre-shave lotion, shaving cream, shampoo, rinse,
Hair treatments such as hair treatments, hair styling agents, perm agents, hair tonics, hair dyes, hair growth and hair restoration, makeup cosmetics such as foundation, lipstick, blusher, eyeshadow, eyeliner, mascara, perfumes, bath agents In addition, it can be applied to various products such as toothpaste, mouth freshener / gargle, deodorant / deodorant, sanitary cotton, wet tissue, and can be used for general food / drinks.

[0089]

EXAMPLES The present invention will now be described with reference to production examples, test examples, and prescription examples, but the present invention is not limited to these examples.

(Production Example 1) 200 g of oil palm extract was warm-extracted with purified water (about 80 ° C.) for about 5 hours or immersed in an organic solvent, extracted at room temperature for 5 days and nights, and filtered to obtain an extract ( 1.0 kg of dry solids: about 0.3-2.5% by weight).

(Production Example 2) 200 g of a plant containing a polyphenol derivative was warm-extracted with purified water (about 80 ° C.) for about 5 hours or immersed in an organic solvent, extracted at room temperature for 5 days and nights, and then filtered. Extract liquid (dry solid content: about 0.3-2.5% by weight) to about 1.
Get 0kg. (Polyphenol content about 0.5% by weight)

(Test 1) Elimination of active oxygen (SOD-like activity)
Test In recent years, many diseases and diseases induced by active oxygen have been reported, and it has been pointed out that removal and elimination of active oxygen (SOD activity) leads to prevention of tissue damage. In this test, the ability of each sample to scavenge active oxygen generated by the xanthine-xanthine oxidase system was measured by the Nara
BT method (Lipid peroxide experiment method, P.144, Medical and Dental Publishing Co., Ltd.)
It examined using.

"Test Method and Evaluation Method" a. Sample Each extract was distilled under reduced pressure to remove the solvent, then redissolved in purified water to a solid concentration of 0.1% by weight, and used for the test. When multiple extracts are used, the solvent is distilled off from each extract under reduced pressure, then mixed in equal amounts and redissolved in purified water to a solid concentration of 0.1% by weight. Provided. b. Measurement of active oxygen scavenging ability 2.5m in 0.05M sodium carbonate buffer (pH 10.2)
L, 0.75 mM nitro blue tetrazolium (NBT), 3.0
mM xanthine, 3.0 mM disodium ethylenediaminetetraacetate, 0.15 w / v% bovine serum albumin, and 0.1 mL each of the sample solution (the solvent for the control) were added, and the mixture was kept at 25 ° C for 10 minutes.
0.1 mL of an aqueous solution of xanthine oxidase (adjusted so that the change in absorbance of NBT in the control is about 0.3 / 20 minutes) was added, and the absorbance at 560 nm was measured. The sample containing purified water in place of the sample was used as a control. For each sample and control, a blank containing a reaction stop solution was set before adding xanthine oxidase. The results are shown in FIG.

<Equation 1> Active oxygen scavenging rate (%) = ｛1- (sample OD value−blank)
(Sample) OD value) / (Control OD value-Blank (Control) OD
Value) x 100

(Test Results) As shown in FIG. 1, it was confirmed that the mixture of the oil palm extract and the polyphenol derivative of the present invention had an excellent active oxygen scavenging effect.

(Test 2) Lipid Peroxide Production Inhibition Test Lipid peroxide is obtained by adding a peroxide, mainly a hydroperoxide, to an unsaturated fatty acid which is a component of lipid. These lipid peroxides cause damage to cell membranes in vivo, inactivate various enzymes, denature biological proteins, etc., and adversely affect biological tissues. As a result, it is thought that it promotes aging and leads to diseases such as cancerous changes. In the skin, the accumulation of lipid peroxides caused by the peroxidation of sebum causes changes in the cell membrane and mitochondrial function of the skin, causing liver spots, melasma, primary irritant dermatitis, atopic dermatitis It is said to be one of the causes of various skin diseases such as skin aging (wrinkles, senile pigmentation, etc.) and rough skin. Inhibition of lipid peroxidation is regarded as important in dermatology. . In this test, skin-surface lipids and iron-ascorbic acid
The inhibitory effect of squalene on peroxidation was determined by the TBA method (Analytical, Biochemistry. Vol.95, P351-35
8 (1979)).

[Test Method and Evaluation Method] Squalene was added to a 1% aqueous solution of polyoxyethylene (10) octyl phenyl ether at a concentration of 0.1%, ammonium iron sulfate at 8M and ascorbic acid at a concentration of 38M, and dissolved. Take in a small test tube. To this is added 0.1 mL of the sample solution, placed in a thermostat at 37 ° C., and left for 3 hours. After completion of the reaction, add 1 mL of the reaction solution.
Take 0.01 mL of 4.5% dibutylhydroxytoluene and 0.67
% 2-thiobarbituric acid, 15% acetic acid aqueous solution (pH 3.5) 1m
Add L and heat at 95 ° C for 1 hour. After cooling, add 4 mL of butanol containing 15% methanol, shake well, and centrifuge. The absorbance at 534 nm of this butanol layer was measured and defined as the amount of lipid peroxide. In addition, a sample containing purified water instead of the sample was used as a control, an unreacted blank was set for each sample and the control, and the inhibition rate of lipid peroxide production was determined by the following equation (Equation 2). Indicated. The solvent of each “sample” extract was distilled off under reduced pressure, then redissolved in purified water to a solid concentration of 0.1% by weight, and used for the test. When multiple extracts are used, the solvent is distilled off from each extract under reduced pressure, then mixed in equal amounts and redissolved in purified water to a solid concentration of 0.1% by weight. Provided. As a comparative sample, an aqueous dl-α-tocopherol solution (manufactured by Kishida Chemical Co., Ltd.) was prepared under the same conditions and used for the test.

<Equation 2> Lipid peroxide production inhibition rate (%) = ｛1− (sample OD value−blank (sample) OD value) / (control OD value−blank (control))
OD value)｝ × 100

(Test Results) As shown in FIG. 2, it was confirmed that the mixture of the oil palm extract and the polyphenol derivative of the present invention had a stronger inhibitory effect on lipid peroxide production than the aqueous dl-α-tocopherol solution. .

(Test 3) Histamine Release Inhibition Test In an immediate allergic reaction, chemical mediators such as histamine are released from mast cells or basophils sensitized in the second stage. Therefore, a substance that suppresses histamine release can be expected to have an antiallergic effect. In this test, histamine releasing reagent co
Test method for releasing histamine with mpound48 / 80 (J. Soc. C
osmet.Japan, Vol.25, No.4, P.246 (1992))
Each sample was examined.

"Test method and evaluation method" a. Sample Each extract was distilled under reduced pressure to remove the solvent, then redissolved in purified water to a solid concentration of 0.1% by weight, and used for the test. When multiple extracts are used, the solvent is distilled off from each extract under reduced pressure, then mixed in equal amounts and redissolved in purified water to a solid concentration of 0.1% by weight. Provided. As a comparative sample, cromolyn (manufactured by Sigma) was prepared under the same conditions and used for the test. b. Measurement of the amount of free histamine A 0.2 mL sample was added to 1.2 mL of a mast cell suspension collected from the intraperitoneal cavity of a rat (Slc: Wister male rat, about 4 to 9 weeks old).
And compound48 / 80 were added to a final concentration of 1 μg / mL, and incubated at 37 ° C. for 15 minutes. After stopping the reaction by cooling on ice, the reaction solution was centrifuged, the histamine released from the supernatant was extracted and purified, and the color was developed with o-phthaldialdehyde.The fluorescence absorbance at an excitation wavelength of 360 nm and a fluorescence wavelength of 450 nm was measured. The histamine release inhibition rate was determined by the following equation (Equation 3), and the results are shown in FIG.

<Equation 3> Histamine release inhibition rate (%) = ｛1- (AC / B−)
C)｝ × 100 A: Fluorescence intensity of histamine released when a histamine releasing agent was added in the presence of a sample in mast cells B: Fluorescence intensity of histamine released when a histamine releasing agent was added to mast cells C: Fluorescence intensity of histamine naturally released from mast cells (A, B and C are measured values minus blind values)

(Test Results) As shown in FIG. 3, it was confirmed that the mixture of the oil palm extract and the polyphenol derivative of the present invention had a higher histamine release inhibitory action than cromolyn.

(Test 4) Anti-Complement Activity Test The complement system plays an important role in the immediate allergy involving antibodies other than the IgE antibody. Substances that affect this complement system include allergies,
It may affect the formation of disease such as inflammation. In this test, the test was performed using an anti-complement activity measurement method using the hemolytic reaction of sensitized red blood cells of each sample as an index.

"Test Method and Evaluation Method" a. Gelatin / veronal buffer solution (GVB ²⁺ ) 1.7 g of sodium chloride, 0.115 g of barbital, 0.075 g of sodium barbital, 0.015 g of calcium chloride, 0.010 g of magnesium chloride, 0.2 g of gelatin, and 100 mL of purified water are adjusted to pH 7.5. Thereafter, the total amount was adjusted to 200 mL with purified water. b. Sheep red blood cell (SRBC) suspension Sheep blood is centrifuged at 2,000 rpm for 5 minutes, washed three times with physiological saline, and GVB ²⁺ is added to the sediment to prepare a 10% SRBC suspension, which is finally SRBC 3.05 to 0.25 mL of suspension
When complete hemolysis was performed by adding 0.1 mL of a 0.1% sodium carbonate solution, the absorbance at 540 nm was adjusted to 0.455. c. Anti-SRBC Mouse Serum 0.2 mL of 10% SRBC suspension was injected intravenously into the tail of IVCS male mice, 4 days later, blood was collected, serum was separated and GVB
^It was diluted 40 times with ²⁺ and used. d. Complement Guinea pig fresh serum was diluted 20-fold with GVB ²⁺ and used. e. Measurement of anti-complement activity 0.1 mL of sample in 0.5 mL of GVB ²⁺ and 0.5 mL of anti-SRBC serum, S
After 0.25 mL of the RBC suspension and 0.25 mL of the complement solution were sequentially added, the reaction was carried out in a thermostat at 37 ° C. for 60 minutes. 10 in ice water
After leaving the reaction to stand for
After centrifugation for 0 minutes to separate unlysed red blood cells, the OD value of the supernatant at 540 nm was measured. A sample containing purified water instead of a sample was used as a control, a blank containing no serum was set for each sample and control, and the complement activity inhibition rate (= anti-complement activity) was calculated by the following formula And the results are shown in FIG. The solvent of each “sample” extract was distilled off under reduced pressure, then redissolved in purified water to a solid concentration of 0.1% by weight, and used for the test. When multiple extracts are used, the solvent is distilled off from each extract under reduced pressure, then mixed in equal amounts and redissolved in purified water to a solid concentration of 0.1% by weight. Provided. As a comparative sample, dipotassium glycyrrhizinate (manufactured by Alps Chemical Industries) was prepared under the same conditions and used for the test.

<Equation 4> Complement activity inhibition rate (%) = ｛1- (sample OD value−blank)
(Sample) OD value) / (Control OD value-Blank (Control) OD
Value) x 100

(Test Results) As shown in FIG. 4, it was confirmed that the mixture of the oil palm extract and the polyphenol derivative of the present invention had an excellent anti-complement activity as compared with dipotassium glycyrrhizinate.

(Test 5) Safety test (1) Primary skin irritation test The mixture obtained in the present invention was prepared with purified water so that the dry solid content concentration was 0.5%, and the back was shaved. It was applied to the skin of rabbits (female, 3 per group, body weight around 2.5 kg). The judgment was made 24, 48, and 72 hours after application by the primary irritation scoring method using erythema and edema as indices. The result was negative in all animals without any erythema and edema.

(Test 6) Safety test (2) Skin cumulative irritation test Similarly, the mixture obtained in the present invention was dried at a dry solid content of 0.5.
%, And applied to the skin of a Hartley-type guinea pig (female, 3 animals per group, body weight of about 330 g) with shaved flank once a day, 5 times a week, 0.5 mL / animal. did. Application was performed over two weeks and shaving was performed on the last application day of each week. The determination was made on the day following each application day and the day after the last application day by using the primary irritancy scoring method with erythema and edema as indices. As a result, all animals were judged negative without any erythema and edema over 2 weeks.

(Test 7) Safety test (3) Acute toxicity test Similarly, the powder obtained by concentrating and drying the mixture obtained in the present invention under reduced pressure (dry solid content: 1.0%) was subjected to the following tests. Ddy mice (male and female, 5 mice per group,
(5 weeks old) orally at a dose of 2,000 mg / kg, and the appearance and degree of toxicity symptoms were observed over time. As a result, no abnormalities were observed in all the mice for 14 days, and there was no abnormality in the dissection results. Therefore, the LD50 was determined to be 2,000 mg / kg or more.

(Prescription examples) Production of active oxygen scavenger, lipid peroxide production inhibitor, antiallergic agent and cosmetic composition According to the above evaluation results, the formulation examples are shown below. May be produced by a conventional method in the production of, and only the compounding amount is shown. Further, the present invention is not limited to these.

(Formulation Example 1) Emulsion weight% 1. Squalane 8.0 2. Jojoba oil 7.0 3. Cetyl alcohol 1.5 4. Glycerin monostearate 2.0 5. Polyoxyethylene (20) cetyl ether 3.0 6. Polyoxyethylene (20 ) Soorbitan monooleate 2.0 7.1,3-butylene glycol 1.0 8. Glycerin 2.0 9. Extract of 30% sunflower syrup, 1,3-butylene glycol 1.0 extract 10. Residue with 100 purified water

(Formulation Example 2) Peel-off pack (% by weight) 1. Glycerin 5.0 2. Propylene glycol 4.0 3. Polyvinyl alcohol 15.0 4. Ethanol 8.0 5. Polyoxyethylene glycol 1.0 6. Hyaluronic acid solution 1.0 7. Extraction of 50% ethanolic oil Liquid 2.0 8. Rosemary 50% ethanol extract 2.0 9. Appropriate perfume 11. Appropriate preservative (paraoxybenzoate) 12. Purified water 100

(Formulation Example 3) Cold cream weight% 1. Salicone beeswax 11.0 2. Liquid paraffin 22.0 3. Lanolin 10.0 4. Almond oil 15.0 5. Novara extract 1.0 6. Borax 0.5 7. Sunflower 30% 1,3-butylene Glycol extract 2.0 8. Aloe 50% 1,3-butylene glycol extract 1.0 9. Preservative (methyl benzoate) 0.1 10. Appropriate perfume 11. Purified water 100

(Formulation Example 4) Body soap weight% 1. Potassium laurate 15.0 2. Potassium myristate 5.0 3. Propylene glycol 5.0 4. Oil extract 50% 1,3-butylene glycol extract 1.0 5. Salvia 30% ethanol extraction Liquid 0.5 6. Amino acid (valine, leucine, etc.) 0.5 7. Preservative (propyl benzoate) qs 8. pH adjuster qs 9. Purified water 100

(Formulation Example 5) Shampoo wt% 1. Triethanolamine lauryl sulfate 5.0 2. Sodium polyoxyethylene lauryl ether sulfate 12.0 3.1,3-butylene glycol 4.0 4. Diethanolamide laurate 2.0 5. Disodium edetate 0.1 6. Extract of 30% sunflower oil, phenolic alcohol recall 2.0 7. Arnica, 30% 1,3-butylene recall extract 1.0 8. Appropriate amount of antibacterial and preservative (resorcinol) 9. Appropriate amount of pH adjuster 10. Appropriate amount of fragrance 11. Purified water 100 Residue to do

(Formulation Example 6) Rinse weight% 1. Stearyltrimethylammonium chloride 2.0 2. Cetostearyl alcohol 2.0 3. Polyoxyethylene lanolin ether 3.0 4. Propylene glycol 5.0 5. Extract of 50% sunflower tomato phenolic alcohol 1.0 6. Melissa 50% 1,3-butylene glycol extract 1.0 7. Hydrolyzed silk solution 1.0 8. Antibacterial and preservative (benzalkonium chloride) qs 9. perfume qs 10. Purified water 100

(Formulation Example 7) Hair liquid% by weight 1. Ethanol 29.0 2. Polyoxypropylene butyl ether phosphoric acid 10.0 3. Polyoxypropylene monobutyl ether 5.0 4. Triethanolamine 1.0 5. Hot water extract of oil palm oil 1.0 6. Button pi 50% ethanol extract 1.0 7. Seaweed extract 1.0 8. Hydrolyzed elastin solution 1.0 9. Antibacterial and preservative (paraben, benzalkonium chloride) qs 10. spices qs 11. Purified water 100 residue

(Formulation Example 8) Hair tonic% by weight 1. Ethanol 40.0 2. Ethyl oleate 1.0 3. Polyoxyethylene (40) hydrogenated castor oil 2.0 4. Sunflower syrup 50% 1,3-butylene glycol extract 1.0 5. Comfrey 50% 1,3-butylene glycol extract 1.0 6. Sodium hyaluronate solution 1.0 7. Carboxymethyl chitin solution 1.0 8. Whey solution 1.0 9. Mucopolysaccharide solution 1.0 10. Antibacterial and preservative (paraben) 0.1 11 Appropriate amount of fragrance 12.Purified water 100 residue

(Formulation Example 9) Agent for granule bath weight% 1. Sodium bicarbonate 58.0 2. Anhydrous sodium sulfate 30.0 3. Borax 3.0 4. Oil extract 70% ethanol 5.0 5.0 Yukinoshita 30% ethanol extract 2.0

(Formulation Example 10) Coating protective agent A gauze or liniment cloth is impregnated with a formulation solution containing an appropriate amount of a 30% ethanol extract of oil palm, 30% ethanol extract of peach leaves, antibiotics, anti-inflammatory, etc. Attach. Alternatively, a 30% ethanol extract of sunflower and a 30% ethanol extract of peach leaves may be directly applied locally and covered with gauze or the like.

(Test 8) Use effect test The effect when the cosmetic composition of the present invention was actually used was examined. The use test is a panel of 10 people aged 30 to 60 years old who are worried about spots, freckles, dark and dark, and those who are worried about dry skin and no shiny skin. This was done by applying an appropriate amount of the emulsion of Example 1 to the face for 3 months. As a control, a preparation prepared by removing the oil extract or polyphenol derivative from Formulation Example 1 in a similar manner was used. The evaluation was performed according to the following criteria.
As shown in Table 2, the numbers in the table represent the number of people. No one complained of skin abnormalities during the use period.

"Improvement of spots, wrinkles, and skin color" Effective: Stain, wrinkles and skin color are white and reduced. Slightly effective: White spots and wrinkles and skin color were slightly reduced. Ineffective: No change from before use.

[0124]

"Effect of improving skin feel" Efficacy: Dry skin and skin gloss / tension increased, and skin was improved. Slightly effective: Dry skin and skin gloss / tension increased slightly, and skin was improved. Ineffective: No change from before use.

[0126]

(Test Results) As shown in Tables 1 and 2, the emulsion containing the extract of the oil palm sunflower and the polyphenol derivative of the present invention significantly improved dry skin, gave gloss and firmness to the skin, and showed stains. ， It was confirmed that buckwheat and skin color were also white and reduced.

(Test 9) Use effect test The effect when the skin care cosmetic composition of the present invention was actually used was examined. The use test is for people suffering from eczema and rough skin.
The washing was performed twice a day, in the morning and at night, by applying an appropriate amount of the emulsion of Formulation Example 1 to the face over three months after washing the face. As a control, a preparation prepared by removing the oil extract or polyphenol derivative from Formulation Example 1 in a similar manner was used. The evaluation was performed according to the following criteria. The results are as shown in Table 3 and the numerical values in the table represent the number of persons. No one complained of skin abnormalities during the use period.

"Beautiful skin effect" Efficacy: Eczema and rough skin were improved. Somewhat effective: Eczema and rough skin were slightly improved. Ineffective: No change from before use.

[0130]

(Test Results) As shown in Table 3, it was confirmed that the emulsion containing the mixture of the oil palm extract and the polyphenol derivative of the present invention improved eczema and rough skin.

[0132]

The active oxygen scavenger, lipid peroxide production inhibitor, antiallergic agent and cosmetic composition containing the mixture of the oil palm extract and the polyphenol derivative of the present invention significantly eliminate and suppress active oxygen. In addition, to suppress the production of lipid peroxide. Furthermore, a histamine release inhibitory action and an anti-complement activity were confirmed. And to reduce skin spots and freckles on the skin. It can also improve skin inflammatory diseases (for example, redness, edema, eczema, etc.), rough skin and dry skin, and can also give the skin a gloss and firmness.
It is safe for animals. The present invention can be used for other general foods and drinks.

[Brief description of the drawings]

FIG. 1 is a diagram showing the active oxygen scavenging effect of a mixture of a sunflower extract and a polyphenol derivative of the present invention.

FIG. 2 is a graph showing the lipid peroxide production-suppressing effect of a mixture of the oil palm extract and the polyphenol derivative of the present invention.

FIG. 3 is a graph showing the histamine release inhibitory effect of a mixture of the oil palm extract and the polyphenol derivative of the present invention.

FIG. 4 is a graph showing the anti-capturing activity of a mixture of the oil palm extract and the polyphenol derivative of the present invention.

Continued on the front page (51) Int.Cl. ⁷ Identification symbol FI Theme coat II (reference) A61P 17/00 A61P 17/00 37/08 37/08 39/06 39/06 // A61K 7/06 A61K 7/06 7/08 7/08 7/50 7/50 F term (reference) 4C083 AA072 AA082 AA111 AA112 AA122 AB272 AB312 AB352 AC022 AC072 AC102 AC122 AC182 AC242 AC352 AC422 AC432 AC442 AC471 AC472 AC482 AC532 AC542 AC582 AC692 AC782 AC902 AD042 AD112 AD332 AD322 AD412 AD452 AD512 CC05 CC07 CC23 CC25 CC37 CC38 CC39 EE09 EE12 EE13 4C088 AB59 AC01 BA08 CA03 MA02 MA63 ZA89 ZB13

Claims (4)

[Claims] 1. An active oxygen scavenger characterized by containing a sunflower extract and a polyphenol derivative. 2. A lipid peroxide production inhibitor characterized by containing a sunflower extract and a polyphenol derivative. 3. An anti-allergic agent comprising an extract of oil palm and a polyphenol derivative. 4. An active oxygen scavenger according to claim 1, wherein
Any one of lipid peroxide production inhibitor and antiallergic agent
A cosmetic composition comprising at least one kind.