JP2000281528A - Cosmetic composition - Google Patents

Abstract

PROBLEM TO BE SOLVED: To obtain a novel and safe cosmetic composition. SOLUTION: The melanin formation inhibitor, active oxygen scavenger, lipoperoxide formation inhibitor, antiallergic agent, histamine liberation inhibitor, anticomplementary activator or cosmetic composition containing an extract from Rhei rhizoma is obtained. The cosmetic composition shows melanin formation inhibitory effect, active oxygen scavenging effect, lipoperoxide formation inhibitory effect, antiallergic effect, histamine liberation inhibitory effect or anticomplementary activation effect and exerts a stain or freckel reducing effect and a bleaching effect. Further, the skin inflammatory disease (e.g. rubor, edema, eczema or the like), skin roughness or dry skin is improved and the gloss and tension can be given to the skin. Furthermore, it can be utilized for other general foods and beverages.

Description

DETAILED DESCRIPTION OF THE INVENTION

[0001]

The present invention relates to a melanin production inhibitor, an active oxygen scavenger, a lipid peroxide production inhibitor, an antiallergic agent, a histamine release inhibitor or a cosmetic composition containing rhubarb extract. It is about.

[0002] The field of application is, for example, applicable to all kinds of external preparations (including preparations for animals), and specifically, ampules, capsules, pills, tablets, powders, granules, solids, 1) Pharmaceuticals, 2) of liquid, gel or air bubbles
Quasi-drugs, 3) topical or systemic skin cosmetics (e.g., basic cosmetics such as lotions, emulsions, creams, ointments, lotions, oils, packs, facial cleansers and skin cleansers, massage agents) , Cleansing agent, depilatory, depilatory, shaving treatment, after-shave lotion, pre-show lotion, shaving cream, etc.),
4) Pharmaceutical or / and cosmetic preparations applied to the scalp / hair (eg, shampoos, rinses, treatments, permanent solutions, hair dyes, hair styling agents, hair tonics, hair restoration / hair restoration, etc.), 5 ) Bath agents to be poured into bath water, 6) Others, axillary odor inhibitor, deodorant, deodorant, sanitary goods, sanitary cotton, wet tissue, mouth freshener (for example,
Brushing, mouthwash, etc.).

[0003]

2. Description of the Related Art Factors determining human skin color include the amount of melanin in the epidermis, blood flow in capillaries, pigments derived from food (carotene), and the thickness of the stratum corneum. One of the most important factors is melanin pigment. The so-called liver spots (spots), sparrow egg spots (buckwheat spots), and pigmentation of the skin after sunburn are those in which the production of melanin pigments has been significantly enhanced by the activation of pigment cells present in the skin. And for women, it is one of the major worries of the skin.

[0004] The melanin pigment is produced by melanosomes, which are organelles in pigment cells (melanocytes) present in the basal layer of the epidermis, the hair root, and the outer root sheath. In the process of melanin pigment production, tyrosine is activated by tyrosine in pigment cells (melanocytes) to oxidize tyrosine,
It is converted to dopa and dopaquinone, further autoxidized, polymerized via dopachrome and 5,6-dihydroxyindole, and finally turned into a melanin pigment. The produced melanin is secreted by the dendrites of pigment cells (melanocytes) into basal cells, which divide and rise as spinous cells, reach the stratum corneum, and fall off as the stratum corneum detaches. It is going to go.

[0005] Therefore, in order to prevent or improve skin spots, spots and freckles, and darkness of the skin, it is necessary to inhibit the production process of melanin. Alternatively, it is conceivable to make already generated melanin lighter. Therefore, various whitening components have been conventionally proposed based on these ideas. For example, kojic acid or a derivative thereof, ascorbic acid or a derivative thereof, tocopherol or a derivative thereof, glutathione, hydrogen peroxide, zinc peroxide, hydroquinone monobenzyl ether, placenta extract, silk extract or plant extract (Arnica, Altea , Aloe, Japanese gourd, Japanese radish, chamomile, licorice, gardenia, genoshoko, sicon, ginger, birch, senkyu,
Gennoshoko, psycho, sasanqua, Toki, calendula, elderberry, safflower, garlic, adlay, litchi, logwood), etc. were known.

In recent years, the production of active oxygen in a living body and various effects (diseases) caused thereby have been reported. Generally, this active oxygen is also called Activated oxygens, and is roughly classified into four types, O ²⁻ , H ₂ O ₂ , .OH, and chemiluminescence. Captured as important substances involved in defense, for example, when foreign enemies (antigens) such as bacteria, viruses, and foreign substances enter the living body, phagocytic neutrophils, monocytes, and macrophages in the blood first phagocytose. Initiating action, then active oxygen is produced to dissolve the phagocytosed foreign material in the phagocytic endoplasmic reticulum, and this produced active oxygen is responsible for dissolving the phagocytosis, while It directly exerts a bactericidal action on external enemies such as bacteria and foreign substances, and plays a role of protecting them from external enemies. In other words, it has the function of eliminating antigenic substances before the immune function works.

[0007] However, if active oxygen for self-defense is produced and secreted in excess, even normal cells are lysed and stimulated, resulting in various damage reactions. Recently, many diseases and diseases induced by active oxygen have been reported. For example, fats and oils such as cholesterol in blood are oxidized by active oxygen, and vascular disorders due to arteriosclerosis in the brain and heart (stroke, myocardial infarction, etc.) It is said that during blood trauma or cerebral trauma, blood flow is impaired due to thrombus or the like, or ischemic state in blood vessels due to rapid transient atrophy, thereby causing oxygen deprivation. Therefore, in this state, it is said that xanthine dehydrogenase in the blood vessel is converted to xanthine oxidase, which generates a large amount of active oxygen in the blood in the blood vessel, causing damage to the blood vessel wall and causing fatal damage I have.

Further, regarding the relationship between the skin and the active oxygen, for example, since the skin is an organ which is in direct contact with the outside world, the active oxygen is excessively exposed to the skin by ultraviolet rays or radiation while being susceptible to environmental factors. If the state continues, it reacts with the unsaturated fatty acids of the phospholipids of the biological membrane, and the lipid peroxides are generated. The generated lipid peroxide causes arteriosclerosis, carcinogenesis, aging, membrane destruction, protein denaturation, etc., and also causes skin inflammation, edema, wrinkles, and the like. Further, as a disease due to excess active oxygen, from a cosmetic viewpoint, for example, herpetic dermatitis, X-ray dermatitis, burns, trauma, solar dermatitis, contact dermatitis,
Eczema, atopic dermatitis, etc.
There is a need for a substance that eliminates excess active oxygen present in a living body. In order to prevent or improve various diseases, for example, in a living body of animals and plants, superoxide dismutase (SOD), catalase, Glutathioperoxidase and other tocopherols (vitamin E), oryzanol, plant extracts (hamamelis, melissa, emisoso, birch, sage, rosemary, age, basil, ginkgo, psycho, peonies, hange, cahig, tissou, ogon, carrot ,
Licorice, ginger) and the like were used. Examples of lipid peroxide production inhibitors include β-carotene, plant extracts (cultured cells of sesame, amacha, hypericum, hamamelis, melissa, emmeiso, birch, sage, rosemary,
Minami Minami, Agetsu, Ginkgo, green tea) were known.

On the other hand, due to the recent deterioration of environmental conditions, changes in lifestyle, and increased stress due to the complication of social life, hay fever, allergic rhinitis, bronchial asthma, atopic dermatitis, urticaria due to drugs, etc. More and more people suffer from allergic diseases, rough skin, dry skin and the like. In particular, atopic dermatitis has been attracting attention as one of the modern illnesses, with its increase being sought in not only children but also in a wide range of ages up to adults.

[0010] In order to eliminate foreign substances (antigens such as bacteria, pollen, ticks, etc.) that have entered the body, the body must protect the body by producing biological components (antibodies, lymphocytes, etc.) against it. It has an immune function that works. However, sometimes the reaction becomes too sensitive and harmful to the body,
It can cause various diseases. The disorder reaction caused by this immune function is called allergy, and is classified into immediate type and delayed type.

In the allergic reaction, the immediate onset type (types I to III) has a high frequency of onset, and mainly immunoglobulin E
(IgE) is a reaction involving antibodies. This IgE is produced against allergens that have entered the body and has a strong effector effect on mast cells and basophils. Mast cells and basophils (a type of leukocyte) Cells having granules containing pharmacologically active amines such as serotonin, the former being present around blood vessels and connective tissues, and the latter being present in blood. On these cell membranes, receptors that bind IgE antibodies are present and have the property of strongly binding to IgE antibodies, and Ig bound to mast cells and basophils.
When the same type of allergen binds again to the E antibody, a number of active substances such as histamine and serotonin are released from these cells with degranulation, causing various allergic symptoms, and itching and redness and bulging of the skin Symptoms of rash (urticaria), inflammation of the nose and eyes and itching and increased secretion of nasal discharge and tears, or symptoms of choking of the trachea and causing attacks of dyspnea (bronchial asthma) ) Are classified as allergic diseases of this type.

In immediate allergy, the process can be roughly classified into three stages, and each stage is classified according to the point of action, and attempts are made to prevent, alleviate or treat allergic diseases by administering drugs or the like. I have been. That is, when a foreign antigen enters the body, IgE antibodies are produced by immunocompetent cell lines, and the IgE antibodies are distributed in airway, skin, digestive organs and other mast cells, or in blood. Sensitization is established by sticking to basophils.
This is the reaction referred to as the first step.

Next, when the sensitized cells are again contacted with an antigen, the cells undergo morphological changes such as vacuolation, swelling, and degranulation, and release chemical transmitters such as histamine, serotonin, and SRS-A. I do. This is the second stage reaction.

The released chemical messenger acts on contraction of smooth muscles such as bronchial muscles and gastrointestinal tract, enhancement of capillary permeability, migration of neutrophils, aggregation of platelets, and the like. The process of developing allergic symptoms such as digestive allergy with diarrhea, nasal allergy, and urticaria is the third stage reaction.

Therefore, in a narrow sense, drugs acting in the first and second stages are prophylactics for allergic reactions,
Those acting in stages can be considered as symptomatic treatments. Currently, the most active research on antiallergic drugs is the development of drugs that suppress this second stage.

[0016] Type II allergy is known as a damaging reaction caused by the destruction of tissue cells by IgG and IgM antibodies. IgG and IgM antibodies acting on this system significantly activate the complement system when linked to an antigen. (Effector action). The reaction mechanism is based on the fact that IgG and IgM antibodies bind to antigen cells such as microorganisms, thereby activating the complement system and destroying target cells.

The function of the complement system is to activate the protease system on target cells in a chain, form and destroy the membrane-damaging complex (MAC), and to generate a group of fragments called anaphylatoxins. It takes complex steps such as promoting histamine release from mast cells and attracting polymorphonuclear leukocytes and macrophages to promote foreign body treatment. However, such reactions are caused by virus-infected autologous cells, tissue cells or erythrocytes to which haptens (substances that are not antigenic in nature but produce antibodies when bound to proteins, etc.) or bacteria are bound or adhered. In an immune disease, even if the cells are in their own normal cells, the living body recognizes and causes them as antigen cells. Typical types II allergic diseases include aplastic anemia and hemolytic anemia.

[0018] Type III allergy is a reaction in which a large amount of an antigen-antibody conjugate formed by binding of an antibody to an antigen is deposited on a tissue and damaged. Antibodies involved in this reaction are mainly IgG antibodies, which are reactions involving many factors such as the complement system and polymorphonuclear leukocytes, similar to type II, but the difference from type II is that the antigen is not a cell but a substance Is a major feature. still,
The reaction mechanism is that the produced antigen-antibody conjugate is deposited on tissues such as blood vessels, kidneys, joints, and skin to activate the complement system (effector effect). As a result, a large amount of anaphylatoxin is produced, which increases vascular permeability, contracts smooth muscle, and promotes the release of histamine from mast cells, resulting in inflammation.

Various test methods have been proposed according to the allergic reaction types classified in this way, and approaches to factors effective for preventing or ameliorating allergic diseases have been actively conducted.

[0020]

However, the above-mentioned whitening components, active oxygen-eliminating substances, and lipid peroxide production inhibiting substances have poor stability and solubility in the formulation system.
It was unsatisfactory because it produced unpleasant odors and coloration due to precipitation and decomposition, had insufficient effects at the biological level, and had problems in terms of safety, such as causing rash on the skin.

Many of the conventionally used antiallergic drugs are drugs relating to diseases caused by an immediate allergic reaction whose action point is relatively clear.
For example, for type I allergies, antispasmodics that relax smooth muscle, sympathomimetics that suppress the increase in capillary permeability, and antihistamines are listed. Although it is a drug that acts at a stage and is effective as a symptomatic treatment, most of it is a synthetic drug and has a problem in side effects. Furthermore, active researches have been conducted on the development of drugs effective for type II to III allergies, but at present, no specific antiallergic agent has been found yet.

On the other hand, the most active research on antiallergic agents involved in immediate-type allergic diseases is a drug that suppresses the release of chemical mediators and exhibits an antagonistic effect on the released chemical mediators. The development of drugs that suppress the second stage, such as drugs, has not yet been found to have sufficient efficacy.

[0023]

In view of these circumstances, the present inventors have studied the effects of suppressing melanin production and eliminating active oxygen (SO
D) The theme of the development is a useful plant that has an action, a lipid peroxide production inhibitory action, and an anti-allergic action (histamine release inhibitory action, anti-captive activity), and as a result, rhubarb extract will produce melanin pigment. Significantly suppress and have a whitening effect. Also, active oxygen should be significantly eliminated and suppressed.
In addition, the production of lipid peroxide should be suppressed. Furthermore, the effect of suppressing histamine release was confirmed. And to reduce stains and freckles on the skin. In addition, skin inflammatory diseases (for example, redness, edema, eczema, etc.), improvement of rough and dry skin, and a highly safe melanin production inhibitor and active oxygen scavenger that can give gloss and firmness to the skin, The present invention has been completed by providing a lipid peroxide production inhibitor, an antiallergic agent, a histamine release inhibitor, an anticaptor active agent or a cosmetic composition.

[0024]

BEST MODE FOR CARRYING OUT THE INVENTION The term "Rhinobi: rhubarb" used in the present invention means "Polygonaceae",
heum sp.) Plant: Rhubarb (Rheum officinale Baillo)
n) roots, rhizomes, root bark, tuberous roots, but also others, congener plants Datura (R. coreanum Nakai), Maruba rhubarb (R. rhaponticum L.), palm leaf rhubarb (R. palma
tum L.), maple rhubarb (R. tangaticum Maximowic)
z), Carambola (R. undulatum L.), Carambola (R. coreanum Nakai × R. palmmatum L.), (R.
l.), (R. macrocarpum A. Los.), (R. moorcroftiana Royl
e), (R.nobile Hook.f.etThoms.), (R.webbiannum Ro
yle), Rabbit rhubarb (R.frazenbachii Munt.), (R.tatar
Interspecific hybrids such as (icum) and (R. maximoviczii) can also be used.

The rhubarb extract used in the present invention is one obtained by extracting various parts of a plant body (root, rhizome, root bark, tuber, etc.) as they are or after pulverizing them. Alternatively, it is extracted with a solvent as it is or after pulverization.

Examples of the extraction solvent include water and alcohols (for example, lower alcohols such as methanol and ethanol,
Or polyhydric alcohols such as propylene glycol and 1,3-butylene glycol), ketones such as acetone, esters such as diethyl ether, dioxane, acetonitrile, ethyl acetate, xylene, benzene,
Organic solvents such as chloroform can be used alone or in any combination of two or more kinds, and can also be used in a state where each solvent extract is combined.

In addition, rhubarb extract is used as a melanin production inhibitor, an active oxygen scavenger, a lipid peroxide production inhibitor,
Depending on the dosage form and form of the antiallergic agent, histamine release inhibitor, antitrapping agent or cosmetic composition, drying, concentration, dilution, etc. may be optionally performed to prepare.

Although the production method is not particularly limited, it is usually sufficient if it is within the range of the boiling point of the solvent at normal temperature to normal pressure. After extraction, filtration or ion exchange resin is used to perform adsorption, decolorization, Purification may be performed to obtain a solution, paste, gel, or powder. In many cases, it can be used as it is, but if necessary, further purification treatment such as deodorization and decolorization may be added as long as the effect is not affected. An activated carbon column or the like may be used, and ordinary means generally applied to the extracted substance may be arbitrarily selected.

The rhubarb extract of the present invention can be contained in a melanin production inhibitor, an active oxygen scavenger, a lipid peroxide production inhibitor, an antiallergic agent, a histamine release inhibitor, an anticaptor active agent or a cosmetic composition. Although the content thereof is not particularly limited, a melanin production inhibitor, an active oxygen scavenger, a lipid peroxide production inhibitor, an antiallergic agent, a histamine release inhibitor, an anticaptor active agent or a cosmetic composition Slightly, depending on the type, quality and expected degree of action,
Usually, the content is 0.001% by weight or more (hereinafter, expressed as% by weight), preferably 0.2 to 20%. If the content is less than 0.001%, the effect cannot be expected sufficiently.

The melanin production inhibitor, active oxygen scavenger, lipid peroxide production inhibitor, antiallergic agent, histamine release inhibitor, antitrapping agent or cosmetic composition of the present invention comprises the above essential components In addition to the above, if necessary, components and additives exemplified below can be arbitrarily selected and used in combination within a range that does not impair the effects of the present invention.

(1) Various fats and oils Avocado oil, almond oil, fennel oil, perilla oil,
Olive oil, orange oil, orange luffer oil, sesame oil, cocoa butter, chamomile oil, carrot oil, cucumber oil, tallow fatty acid, kukui nut oil, safflower oil, shea butter, soybean oil, camellia oil, corn oil, rapeseed oil,
Persic oil, castor oil, cottonseed oil, peanut oil, turtle oil, mink oil, egg yolk oil, palm oil, palm kernel oil, mocro, coconut oil, tallow, lard, or hydrogenated products of these oils (hardened oil, etc.) .

(2) Waxes Beeswax, carnauba wax, whale wax, lanolin, liquid lanolin, reduced lanolin, hard lanolin, candelilla wax,
Montan wax, shellac wax, rice wax, squalene, squalane, pristane, etc.

(3) Mineral oil Liquid paraffin, vaseline, paraffin, ozokeride, ceresin, microcrystalline wax and the like.

(4) Fatty acids Natural fatty acids such as lauric acid, myristic acid, palmitic acid, stearic acid, behenic acid, oleic acid, 12-hydroxystearic acid, undecylenic acid, tall oil and lanolin fatty acid, isononanoic acid, caproic acid , 2-ethylbutanoic acid, isopentanoic acid, 2-methylpentanoic acid, 2
-Synthetic fatty acids such as ethylhexanoic acid and isopentanoic acid.

(5) alcohols ethanol, isopiranol, lauryl alcohol,
Natural alcohols such as cetanol, stearyl alcohol, oleyl alcohol, lanolin alcohol, cholesterol, and phytosterol, and synthetic alcohols such as 2-hexyldecanol, isostearyl alcohol, and 2-octyldodecanol.

(6) Polyhydric alcohols Ethylene oxide, ethylene glycol, diethylene glycol, triethylene glycol, ethylene glycol monoethyl ether, ethylene glycol monobutyl ether, diethylene glycol monomethyl ether, diethylene glycol monoethyl ether, polyethylene glycol, propylene oxide, propylene glycol , Polypropylene glycol, 1,3-butylene glycol, glycerin, pentaerythritol, sorbitol, mannitol and the like.

(7) Esters: Isopropyl myristate, isopropyl palmitate, butyl stearate, hexyl laurate, myristyl myristate, oleyl oleate, decyl oleate, octyl dodecyl myristate, hexyl decyl dimethyloctanoate, cetyl lactate, Myristyl lactate, diethyl phthalate, dibutyl phthalate, lanolin acetate, ethylene glycol monostearate, propylene glycol monostearate, propylene glycol dioleate and the like.

(8) Metal soaps Aluminum stearate, magnesium stearate, zinc stearate, calcium stearate, zinc palmitate, magnesium myristate, zinc laurate, zinc undecylenate and the like.

(9) Gum, sugar or water-soluble polymer compound Arabic gum, benzoin gum, dammar gum, guaiac oil, Irish moss, karaya gum, tragacanth gum,
Carob gum, quinseed, agar, casein, lactose,
Fructose, sucrose or its esters, trehalose or its derivatives, dextrin, gelatin, pectin, starch, carrageenan, carboxymethyl chitin or alkylene such as chitosan, ethylene oxide (C2-C4)
Oxide-added hydroxyalkyl (C2-C
4) chitin or chitosan, low molecular weight chitin or chitosan,
Chitosan salt, sulfated chitin or chitosan, phosphorylated chitin or chitosan, alginic acid or a salt thereof, hyaluronic acid or a salt thereof, chondroitin sulfate or a salt thereof, heparin, ethyl cellulose, methyl cellulose, carboxymethyl cellulose, carboxyethyl cellulose, sodium carboxyethyl cellulose, hydroxyethyl cellulose , Hydroxypropyl cellulose, nitrocellulose, crystalline cellulose, polyvinyl alcohol, polyvinyl methyl ether, polyvinyl pyrrolidone, polyvinyl methacrylate, polyacrylate, polyalkylene oxide such as polyethylene oxide and polypropylene oxide or a crosslinked polymer thereof, carboxyvinyl polymer, Polyethyleneimine and the like.

(10) Surfactant Anionic surfactant (alkyl carboxylate, alkyl sulfonate, alkyl sulfate, alkyl phosphate), cationic surfactant (alkyl amine salt, alkyl quaternary ammonium salt) ), Amphoteric surfactant:
Carboxylic acid type amphoteric surfactant (amino type, betaine type), sulfate ester type amphoteric surfactant, sulfonic acid type amphoteric surfactant, phosphate ester type amphoteric surfactant, nonionic surfactant (ether type nonionic Surfactants, ether ester type nonionic surfactants, ester type nonionic surfactants, block polymer type nonionic surfactants, nitrogen-containing nonionic surfactants), other surfactants (natural surfactants) , Derivatives of protein hydrolysates,
Polymer surfactants, surfactants containing titanium and silicon,
Fluorocarbon surfactants).

(11) Various vitamins Vitamin A group: retinol, retinal (vitamin A
1), dehydroretinal (vitamin A2), carotene, lycopene (provitamin A), vitamin B group: thiamine hydrochloride, thiamine sulfate (vitamin B1), riboflavin (vitamin B2), pyridoxine (vitamin B)
6), cyanocobalamin (vitamin B12), folic acids,
Nicotinic acids, pantothenic acids, biotins, choline,
Inositols, vitamin C group: ascorbic acid or derivatives thereof, vitamin D group: ergocalciferol (vitamin D2), cholecalciferol (vitamin D
3), dihydrotaxerol, vitamin E group: tocopherol or derivatives thereof, ubiquinones, vitamin K
Group: phytonadione (vitamin K1), menaquinone (vitamin K2), menadione (vitamin K3), menadiol (vitamin K4), other essential fatty acids (vitamin F), carnitine, ferulic acid, γ-oryzanol, orotic acid, vitamin Ps (Rutin, eriocitrin, hesperidin), vitamin U and the like.

(12) Various amino acids Valine, leucine, isoleucine, threonine, methionine, phenylalanine, tryptophan, lysine, glycine, alanine, asparagine, glutamine, serine, cysteine, cystine, tyrosine, proline, hydroxyproline, aspartic acid, glutamic acid , Hydroxylysine, arginine, ornithine, histidine and the like, and their sulfates, phosphates, nitrates, citrates, and amino acid derivatives such as pyrrolidone carboxylic acid.

(13) Various additives derived from plant or animal raw materials These are processed in a usual manner according to the type and form of the product to be added (for example, grinding, milling, washing, hydrolysis, Fermentation, purification, squeezing, extraction, fractionation, filtration, drying, pulverization, granulation, dissolution, sterilization, pH adjustment, deodorization, decoloration, etc. You can choose to serve.

The solvent to be used for the extraction may be selected in consideration of the purpose and type of the product to be provided, the processing to be performed later, and the like. Usually, water and a water-soluble organic solvent (eg, ethanol) are used. ,Propylene glycol,
1, selected from 1,3-butylene glycol)
It is desirable to use a species or a mixture of two or more species. However, when the content of the organic solvent is not preferable depending on the application, only water may be used, or ethanol which is easily removed after the extraction may be used, and may be used alone or in an arbitrary mixed solution with water. Exploited extract may be used.

In addition, additives derived from plant or animal raw materials are
When applied to systemic or topical external preparations and cosmetics, including protection of skin and hair, moisturizing, improvement of feel and texture,
Giving flexibility, relieving irritation, relieving stress by fragrance, activating cells (preventing cell aging), suppressing inflammation, improving skin and hair quality, preventing and improving rough skin, hair growth, hair growth, hair loss prevention, gloss Application, cleaning effect, relief of fatigue, promotion of blood flow,
In addition to cosmetic effects such as a warm bath effect, effects such as fragrance, deodorization, thickening, preservation, and buffering can be expected.

As a specific plant (crude) used as a raw material,
For example, almonds (Hentomo), eye (Aiba), Blue Kazura
(Seifu Wisteria), Aoki (Aoki), Aokiri or Kenasia Ogiri (Otogi), Aotsu-la-Fuji (Kibo), Acacia, Akashoma (Akashoma), Akasuguri "fruit", Aka-grape, Akaminoki (Logwood), Akamegashiwa (Akabu-Kashiwa) , Akane (Akane grass root), Red pheasant or Jiaowei (Jihuang), Agi (Awei), Akinire (Royu skin), Akebi (Kidori),
Asa (John Asako), Malva Asagao or Asagao (Toshiko),
Hydrangea (Apricot), Amacha (Amacha), Ashitaba (Asahiha), Amana (Kojingi), Azuki (Red azuki), Acerola, Asenyak (Asenyaku), Anise, Abemaki fruit, Avocado, Ama, Amacha (Amacha) , Amadorokoro (Jade bamboo), Amaranthus (Amaranthus, Amaranthus, Amaranthus, Arnica, Alpinia, Arnicia, Alpinia ), Aloe (log), aloe vera, angelica, apricot or hon apricot (almond jelly), ansokkou (benzuka), Igakouzolina (ground bile head), epimedium or potash (Inyokaku), rush (light heart grass), knotweed (tiger stick) , Strawberry (first place), strawberry , Figs (fructose "fruits and leaves"), figs (first), ichibi (winter aoiko), Ichiyakusou (one medicinal herb), ginkgo (ginkgo "seed and leaves"),
Itohimemegi (Enshi), Locust bean, Insect beetle (Teirexii), Inuville (Honaguinubiyu), Rice “seed, seed coat”, Inondo “seed”, Ibuki-kusou-so, nettle, ylang-ylang, iwa-tobacco, iwahiba or iwamatsu , Oolong tea, Fennel,
Ukiyagara (Mitsuryo), Uguisukagura "fruit", Himeuikyo, turmeric (Utsukin), duckweed (buoying), Usubasaishin or Keirinsaishin or Oyusaisaishin (spicy), Usvenia oi, Usvenitachioi, Utsubogusa (Summer grass) ), Udo or Shishiudo (Kang, independent, Tang alone),
Japanese apricot (Ume plum "seed, pulp"), Japanese cypress, Elephant's walnut (Kusaco peach), Unshu mandarin (Chen skin), Estragon, Ezocogi (Ezo Goka), Echinashi (Hosobamurasakibarengiku), Echinida, Enokitake (Enotake mushroom) Tola (Keiko), Elderberry "fruit", Elemi, Eryngii or Pre-Lotus Eryngi, Enju (Sophora oleracea, Sophora oleracea), Ogi or Kibanaohagi
(Astragalus), Astragalus (Yoren), Astragalus (Kurokon),
Giant horn (Public incense), giant tiger (self-defense), psyllium
(Worm child, carn grass), toucan (Haruko), Oobanokera or Okera (white jujube), Oobayashabushi "fruit", Oomisehas or hawthorne (Yamasato), Ousei (Narukoyuri, Kagikurumabanarukoyuri), Oohisasanoyuki, Osanosayuki (Barley), giant grass (cereal grass), okaseri (snake bed), oguruma (turnover), okra `` fruit '', panax ginseng or ginseng (ginseng), hypericum or hypericum perforatum or hypericum perforatum
(Brother's cut grass), Odorikosou (intermittent), Onamimomi (blue ears), Origurumi, Onidokoro or Tokoro or Nagadokoro (Hikai), Oninoyagara (Tenma), Oniyuri or Sasasayuri or Hakatayuri (Yuri), Ononis, Halibut (Hihayu) , Ominaeshi (losing sauce), Dutch mustard (Watercress), Dutch jelly, Dutch honeysuckle, olive `` fruit, seeds, leaves '', oregano, orange `` fruits, peels '', calyxio (ripe ground yellow), cacao `` fruits, peels, Seeds '', oysters (persimmons `` leaves ''), kagi kazura (crop hooks), oysters or kantorisou (lotus grass), cassia, casina ki (crops fruit `` fruits ''), gajutsu (grajutsu), Kashiwa (paju trees, porpoises) Leaves), cascarilla, cascara sagrada, kanikusa (kinsato), valerian (yoshikusa root), birch or weeping birch (white birch), pumpkin, kapok tree seed, kahoku sansho (shopper), Ma (bamboo), chamomile or roman chamomile, chamomile (weed), camu cam (camo duck), crow suri, chinara suri (roasted melon), crow bissaku (midsummer), oats, guarana seeds, karaho (thick), karaya, karin (Gourd melon), Garcinia, Kawamidori, Kawara Psycho (Kelyo greens, vermilion grass), Kawazusha, Kawaratake, Kawaranadeshiko (stone bamboo), Ezokawaranadeshiko (Qumugi, Quumiko), Kawaranginjin (blue), Kawarayomogi (Inchinchinko) , Kansui
(Sweet), licorice (licorice), cantaraasa, candelilla,
Kantou, Canna, Raspberry (Ezo strawberry, Dutch strawberry, Shrimp strawberry, Nawashiro strawberry, Maple strawberry, European Raspberry), Kiwi "Fruits, Leaves", Kikarasuri (Ururone), Kikyo (Kikyo, Kikyo root), Kiku (Chrysanthemum, Shimakaniku, Artemisia japonicus, catalpa (Azumitsu), sagebrush (shortshoe), pheasant (Kikomi), squid, scotch aloe, scotch mint, quina, scallop (sincona, red stalk), yellowfin (yellow), gymnema sylvestre, cabbage, cabbage Fruits, cucumber, gyoryu (Nishikawayanagi / Teriyanagi), Kiraja saponaria, Kiraya, Kiranso (gold pea), Kumquat "fruit", betel, beetle, Kinmizuhiki (sensakuraku), guava "fruit", guayule, quelux infe Kutria (Gallery), Kukui Nuts, Kukui (Mushroom, Mushroom, Mushroom) Leaf, ground bone bark), cedar grass (tenmon winter), vine (kuzukon), camphor tree, gooseberry "fruit", ginseng (yellow flower), gardenia (herb), kunugi (bokusou), kumazasa, black pine ), Clara (Bitter), Cranberry `` Fruit '', Chestnut `` Seeds, Fruit, Astringent Skin '', Curculigo Latifolia `` Fruit '', Grapefruit `` Fruits / Leaves '', Buckthorn, Black-tailed Mochi (rescue), Black-blossom Hioki Koshi or Hioki Koshi (Extended life) Grass / life prolonged skin), cloves (cloves, cloves), gumbinazuna (sekimei, sekimeishi), scallop (crop, crocodile spikelets), celosia (cotyledon, rooster), bayberry (laurel tree), kenashisarutoribara (dobukuryo, mountain return) ), Gentian, gennoshoko (old tomato grass), kemponashi (kigushi), koukisekokukoku, kishumitsukan (kouji, tachibana, obenimika) , Fukuremikan, Sagamikouji, ponkan, santara (Tachibanakawa)), march rose
(Monthly flower), Kosui mint, Kozo `` fruit '', Kocha
(Tea), kouhone (river bone), kouhon (straw and karawara), kouriang, kourikyo (takara ginger), cilantro "fruit", kouren (kohuangren), koganebana (yellow gon), bilberry (koshibachi), coconut "Fruit", goshuyu (goshuyu),
Gosho strawberry (covered bonito), pepper (pepper), copaiba balsam, coffee `` seed, leaves '', kobushi or magnolia (spicy), burdock (burdock, burdock), kobotdur, sesame (sesame), sesame clover (ginseng), garnish (Gomiko) Sanekazura or Binankazura or Matsubusa, wheat (wheat), rice or rice bran "red bran, white bran", rice oil, cola acuminata "seed", cola vera "seed", fenugreek "fruit", Colombo, conzulango , Kelp, konjac, konfuri (final barn grass), sisal (sisal asa), saxima button or cinnamon button or cinnamon (weird sen), cherry blossom (oshimazakura, yamazakura, oyamazakura, edhigashi, mamezakura, yamayamazakura, someiyoshino, takanekura) , Kasumi-zakura, Kura, Kohigan, Satozakura, Kanzakura , Flowers, fruits, bark (cherry bark) "), cherries, pomegranate, sasa, sasanqua, sagemodaka (sawaka), sweet potato, sugar cane, sugar beet, satsume jujube (saccharomycin), saffron (banseki, west safflower), pomelo Fruits ”, Saponsou, Salmon berry“ Fruits ”, Sarasinuma (Masahima), Salvia (Sage), Sawagikyo (Yamakona), Sawagurumi (Yamawomo),
Sansuiyousou, Sansin ginseng (37 ginseng), Sanshuyu (sanshuyu), sansho (sansho), sandscon (yamazuone), shea (carite), cyanoki `` fruit '', shiitake (shiitake), shion (shion) , Digitalis, Shikunshi (Kimiko),
Perilla or Aodiso or Chirimendiso or Catamediso
(Shiyo leaves, Shiso), rosewood, linden, Chinese pine,
Chinese forsythia (Linus forsythia), Shimeji (Hinshhimeji, Shakashimeji, Hatakeshimeji, Oshiroishishimeji, Bunashimeji, Shirotamogitake), Shimotsusukesou, Potato, Peony (Shakuyaku), Shajin (Sasan), Janohige (Motomonto), Shushamitsu , Condensed sand), juzdama, palm "fruit", ginger (ginger), jade hydrangea (Tsuneyama),
Shobu (iris, iris root), shrimp "fruit", white oak "seed", white walnut "seed", white adzuki (chicken bone grass), white iris (small iris), white banana (flower), white minant (minamitenmi), shin Konasakushirubura, Jinkoge (Mizuka, Mizuka, Shencho), Cinnamon, Watermelon (watermelon), Honeysuckle (gold and silver flowers, Shinobi),
Sorrel (acid model), swim berry "fruit", stevia, strawberry "fruit", suzu psycho (Xu Chang Lord), horsetail (question), purslane (horse dent, horse dent), plum "fruit", Scots pine "ball" Fruit, larch, vegetation, walnut, walnut, hawthorn, dandelion, horse chestnut (malonie),
Pear “fruit”, snowy pear, elderflower, elderflower, juniper (juniper
Juniper), Achillea millefolium (milfoil), A. rose, A. euphoria, A. mistletoe,
Common mint or Common mint, Horseradish, Horseradish (Ishiiri), Seccot (Ishimasu), Zeniaoi, Hirohasenega, Senega, Seri, Celery, Senkyu
(Kawa-Kyu), Senshinren (Shingenren), Sendan, Senburi (Drug), Senna "Fruits, Leaves", Senninsou (Great Tate), Soka (Grass), Buckwheat "Seeds", Somenimo, Radish, Soybean, Daidai (orange peel, kikomi), Takasaburo (Dried lotus grass), Takatodai (Daisen), Takawarabi (Inu), Dark sweet cherry "fruit", Tachiaoi, Tachijakoso (thyme, Momoka), Tachidokoro (Hikai), Tachiyanagi , Tamarind `` seed '', onion, tamshiba (hot spring), taro tree `` fruit, leaf, root bark '', tanjin (dansin),
Dandelion (Gakukohide) or white dandelion or moko dandelion, dammar, cherry "fruit", Chigaya "fruit,
Roots, buds '', ginseng (bamboo ginseng), chicory, ginseng (gomi), ginseng (buoy), ginseng (ginseng), artemisia (amyo-leaf), ginseng (boiled ginseng), thrush Japanese mushrooms (mushrooms), camellia, camellia, clover (lacquer lacustrine), camellia (ducklings), vines (red red beans), vines (red bean), vines (vegetables), vines (vegetables), vines (four-leaf ginseng), vines, deiko, teuchigurumi , Duberry "fruit", tengusa, tencha (tencha), tendaiyaku (crowd), touga (winter gourd), touoka kazura, capsicum (bank pepper), touki (toki), tokinsenka (marigold), tounabena (river) Corn), corn or corn hair (Nanbaru hair), horned rice mochi (female child), lindaceae, balsam pear (dragon gall), croaker (pirate), Dokudami (jujutsu), radish (root), toshishi or mamedaoshi or scutellaria, eucommia (mushroom "bark, leaves, roots"), ash (qin bark), tomato, tragacanth, triacanthos "seed"
Offspring, Tormentilla, Dronoki, Trolo-aoi, Niseria berry `` Fruit '', Nagaimo yam (Yakuyaku), Nagikadada (Butcher Bloom), Naginata Kouju, Nazuna, Rape, Natame bean or Natameki (sword bean), Natsumikan, Jujube (Dajutsu) ), Naniwaibara (Kanekurako), Navena (intermittent), Nameko, Narco lily (Yellow), Peanut (peanut), Nanten (Namitenmi), Nambankaramushi (ramie),
Nigaki (bitter tree), bitter mugwort (bitter), nutmeg, kei or nikkei or ceylon nikkei or yabnikkei (cinnamon bark)
Or Keishi (Keishi), Chinese Chive (Niriko), Elderberry (Bone-bearing tree "fruit, flower, stem, leaf") Garlic (garlic), Nurde (Fivefold), Leek, Nemoki or Nebu or Nebi or Nemlinoki or Jigokubana (Happiness) ), Nozami (Ohi), Noibara (Fruit), Yarrow, Nodake (Maehu), Nobara, Nomomo,
Palm, pineapple `` fruit '', hibiscus (Bussouge, Furinbussouge, Roselle), Hakamauraboshi (bone crushing), Hakusen (ringworm skin), Huckleberry `` Fruits '', Hakobe (Horuko), Hashibami (Haruko), Hashidokoro
(Roth root), basil, lotus (lotus, lotus, lotus), parsley
(Netherland jelly), naked mussels, batata, bees or medakes (bamboo-boiled), patchouli, mint (lightly-loaded, lightly-leaved leaves), pearl barley (yokuinin), hanasuge (tomochimo), banana, hanamint, hanabishi (situri, shisuturi), vanilla bins ,
Papaya, Hakogusa (rat koji), hub `` whole plant, stem,
`` Leaves '', paprika, hamago or honeysuckle (vine thorns), hamasuge (katsuki), hamabishi (situriko), hamanas (maikai flower), hamabafu (hamaki wind), hamamelis,
Roses (roses), agaric (aragaric, white agaric,
Usukimori no Kasa), Haran, Parietalia, Harunire
(Yu bark, Yu white bark, Yu leaf), Handaikai (Moudai sea), Breadfruit, Hiougi (sun dried), Hikajutsu carrot (party party), Pecan nut, Giganbana (Shirubi, Jinshasha), Hikikoshi (Enmeisou) (Long-lived skin), Hishi (Hishimi), Pistachio, Beet, Hitotsuba (Stone reed), Hitotsubashienida, Hinata Kozuchi (cow knee), Hinoki, Hiba, Castor, Sunflower, Bell pepper, Himeuzu (Tamaoi), Himegama (Kagami) , Himematsutake (Kawariharatake, Hiromatsutake), Pimenta "Fruit", Juniper, Bjakuyu, Hydrangea "Fruit", Beloyd Oy, Hiroha Okinagusa (Hakuto Okina), Loquat "Fruit,
Leaves, stems '', betel nut (large clothing skin, betel nut), sprout
(Southern rattan), Butterflies, Butterbur dandelion (Winter flowers, Wheat leaves), Fujibakama (Orchid grass), Fuji bean (Tan beans), Grape `` Fruits, peels, seeds, leaves '', Beech, Fuyusinatsutake mushroom (Nenzo) Brazilian carrot, black currant `` fruit '', blackberry, plum `` fruit '', flucellaria, blueberry (Prunus avium), prunes, blonde psyllium, bundou (green beans), loofah, safflower (safflower), henneken, belladonna, berries `` `` Fruit '', Peruvian berg, Benikea ficus (Keiten), Boysenberry `` Fruit '', Broomweed or Elderweed or Nendow or Hawakigi / Kokia (skin), Balsam (Hosen, acute child, osteophyte), Bohu (windbreak) ), Spinach, physalis (Torone), honoki (Japanese thick, park), bokeh
(Gourd), Hosovanaokera (Sojutsu), Hosobanokirinsou
(Kageten Sanshichi), Hosobabarengiku, Bodaiju (Bodai tree),
Buttons (peony, peony bark), hops, jojoba, white berries "fruit", hon-oniku (meat porcelain, large art), hon-shimeji, hon-sekkok (iron bark stone, sparrow mountain stone), meizurutennansha (tennan star), Maitake (maitake), ephedra (mao), macadamia nuts, macri (seagrass), maguwa (“mulberry bark“ bark, leaves ”), magnolia or splengeri, matatabi (kiten-tate), matsukasa, pine“ leaves, bark,
Roots, matsuhodo (bukuryo), mayola (Hanaminka), malvanozadin (bitan), mulberry `` fruit '', quince, mango, mangosteen, manshugulumi, mandarin `` fruit '', mannentake (reishi), pheasant (komimi `` fruit '') ), Mishimasaiko (Saiko), Mizuobako Mizuasagao (Ryugoshi), Mizokokushi (Harenbe Lotus), Mizohagi (Chisatsuna), Miyamanagi or Japanese willow (Trends), Mitsugashiwa, Mitsuba, Midorihakka, Mimosa, Mioka, Miracle Fruit "Fruit", Myrrh, Myrobaran, Mukuge (Mokuge), Mukunoki, Mokuji, Murasaki (purple root), Murasakikisukibu / Omurasakishikibu (purple bead), Murasaki maize, Murasaki natsufuji (Kumming chicken blood wisteria), Mehajiki (mass mother plant), Mebaugi, Melaleuca, Melissa, Meliloth, Melon "fruit", Mowberry mugwort, Moso Chic, mokko (mochi), peach (peach `` leaves, seeds, flowers, fruits ''), sprouts, morello cherries `` fruits '', moroheiya (burlap), yakawamurasakiimo, yakuchi (masuti), cornflowers (cornflowers) , Cornflower mint, yashabushi (arrow wheel) or Himeyashabushi or Obayashishabushi `` fruit, peel, ears '', yachiyanagi, yatsude (octagonal gold plate), mistletoe (willow parasitism), willow (kawayanagi, takayanagi, weeping willow, pussyllium, pussy Kinuyanagi, Koriyanagi, Unryuyanagi, Miyayamayanagi, Yamayanagi, Obayanayanagi, Tairikkinuniyanagi,
Fox willow, bonito), willow vine “leaves, stems”, yabugarashi, yabukouji (purple gold beef), yabu tobacco (crane squirrel, Tenna sperm), pokeweed (commercial land), yamahanoki (yamaharu), yamamomo (yumemei), yamamomogi, Eucalyptus, Saxifraga (tiger eargrass), Yucca or flevifolia, Yuzu `` fruit '', lily, yorogusa, mugwort (Aiba), ligan (Rainuma), lime `` fruit '', rye, lacanca `` fruit '', raspberry `` leaf, fruit , Latania (Clameria), Rakkyo Eshallot (Saihaku), Lavender, Longan (Longan meat),
Agave (Aon agave, Fukurin agave), Ryokucha (green tea), Apple "fruit, seeds, leaves, roots", Gentian, Rubus or Suavisimus (sweeten), Lacey (Lichi, Lichi nucleus), Lettuce (Chisha), Red car Land "fruit", lemon "fruit", lemongrass, forsythia (forsythia: forsythia, Chinese forsythia), astragalus, coconut, rokon (reed: 根根),
Loganberry "fruit", rosemary (mannen wax), rose hips (nobara), wasabi, waremokou (jiyu) and the like.

Further, other seawaters, for example, seawater salts, dried seawater, inorganic salts obtained from the Dead Sea or the Atlantic or Pacific Ocean (sodium chloride, magnesium chloride, potassium chloride, etc.), sea mud / mud (fango) Species, for example, sea mud or mud of various places such as Italian Fango, German Fango, Eifel Fango, Freiburg Fango (containing components: silicon dioxide, titanium dioxide, aluminum oxide, iron oxide,
Manganese oxide, sodium oxide, potassium oxide, magnesium oxide, calcium oxide, strontium oxide, sodium, potassium, magnesium, calcium, chromium, iron, copper, nickel, zinc, lead, manganese, arsenic,
Water).

Examples of the seaweeds include seaweeds [green algae: Chlorella vulgaris, Chlorella pyrenoidosa, Chlorella ellipsoidia, Aonori (Usubaonori, Susiaonori, Hiraaonori, Bowaoonori, Hosoedaoonori), and seaweed [brown alga: Kombu algae: Brown algae: Kombu alga; , Resilicon b, hosomekobu, mishitoshibu), seaweed, hirome, blue seaweed, giant kelp (macrocystis pilifera, macrocystis integrifolia, neocitys luetokeana), hijiki, hibamata), seaweed [red alga: hijirimen, maxa ( Tengsa),
Hirakusa, Omikusa, Obakusa, Katao Bakusa, Yatabegusa, Yuikiri, Shimanegusa, Tosakanori, Togekirinsai, Akumasakirinsai, Kirinsai, Zyakushinkirinsai, Tsunomata, Obatsunomata, Tochaka , Ibotsunomata, Yaleus Banori, Kagius Banori,
Suzius Banori, Hyus Banori, Akamomininori] and the like.

Also, other algae, for example, green algae (Chlamydomonas: Chlamydomonas, Akayukimo, Dunaliella: Dunaliella, Chlorococcus: Chlorococcus, Kwanomimo: Kwanomimo, Volvox: Ohikawawari, Volvox, Palmera, Yotsumemo, Spirogyra: Hizaori, Spirogyra, Tulsimidro, Hibimidoro: Hibimidoro, Aosa: Anaoasa, Amiosa, Nagaosa, Kawanori: Kawanori,
Genus Fricciella, genus genus: medusa, asiaticum gutta, kawashiogusa, marimo, baronia: tamagobaronia, tamabaronia, tamagata: tamagatamo, iwata: husaiwata, surichogita, heraiwata, kurokita, kurokita, kurokita Sakibuchimil, Nagamir, Hiramil, and Casanori:
Casanori, Jusmo: Fusuzumo, Tamazumi,
Species of the genus Mizudzumo, Genus Genus, Genus Colecaet, Genus Genus genus, Species of the genus Cyperaceae: Species of the genus Cyperaceae, the genus of the spider genus;

Cyanobacteria (Genus L .: L., L., L., L .: L., mushrooms,
(Hassay, Yuremo, Racenmo (Spirulina) genus: Spirulina, Trichodesmium (Aiakashio), etc.).

Brown algae (Piraella spp .: Piraella spp., Spirogyra spp .: Namiami sp., Isogrape spp .: Isogrape,
Genus Isogawara: genus Isogawara, genus genus: Gunsenkurogashira, genus Kashirazaki: genus Kashirasaki, genus Genus: peaches, Hiramtimo, kebelligsa, genus Amis. Artemisia spp.
Genus genus: genus pine, genus genus: genus genus: genus genus, genus okinawa, genus okinawazuku, genus phlebosum, genus phlebosum, genus phlebosum: genus futomozuku, genus genus moss: genus genus: genus kuromo, genus moss, genus genus Ishige, Irolo, Icmegasa: Icmegasa, Keyari: Keyari, Umibos: Umibos, Urushigusa: Urushigusa,
Betula serrata, Tobacco moss, Laminaria spp. Genus Kagomenori: Kagomenori, Muraridori: Murachidori, Shakusugusa: Sharks
Genus Genus: Genus Genus, Genus Genus: Genus Genus: Genus Genus, Genus Kayamonori, Genus Genus: Genus Genus: Genus Filiformis, Genus Turmo: Genus Tsurumo, Genus Anana: Genus Anastasia, Genus Suzume: Genus Musicum, Genus Missiscoma, Genus L. , Oni-kombu, Gohei-kombu, Naga-kombu, Pea-kombu, Ochimitsu-kombu, Toro-kombu genus: Toro-kombu, Antokume genus: Antokume, Kajime genus: Kajime, Tsuruarame, Kurome, Kikuishicombu genus: Kikuishikombu, Nejirekombu: Nekorecome genus, Kuroshimae : Nekoshikonbu,
Alame: Alame, Ainuwakame: Ainuwakame, Chigaiso, Oniwakameezoishige: Ezoishige, Yabanemoku: Yanemoku, Rapamoku: Rapamoku, Jiromoku: Uganomok, Jiromoku, Hiemomoku, Hokumoku, Tamamomoku, Tamamomoku Akamoku, Shidamoku, Hondawara, Nejimoku, Narasamo, Mametarawara, Tatsukuri, Yasumatamoku, Umitrano, Oobamoku, Fushizushimoku, Hahakimoku, Togemoku, Jolemoku, Saw-moku, Obanoki-mimoku, Genus genus:
Bulukimo, genus cynomolgus: cynomolgus etc.).

Red algae (Russula genus: Bovine genus, Funorinoshiki, Amanori genus: Asakusanori, Susabinori,
Genus Upirinori, Onimanori, Tasa, Filitasa, Benitasa, Rhodocorton: Milnoveni, Akebonomozuku: Akebonomozuku, Konahada: Hikonahada, Yogorekonahada, Aokonahada, Sea Species: Acacia sylvestris, Ochryllidae, Ochryla : Pine tree, genus Fusanori: Fusanori, Nisefusanori: Nisefusanori,
Sodegarami: Sodegarami, rattles: rattles, rattles, hirohatamataki: hirohatamatamadaki, tamamaidaki: tamaitadaki, kakenokenori: kaginori, kakenenori, tengusa, swordfish, swordfish, swordfish, swordfish, swordfish, and swordfish Genus: hibiroudo, himebiroudo,
Genus genus: genus isensis, genus genus:
Genus spp., Ryumonsou spp. Genus Ikawanokawa, Genus Kanokawa: Kainokawa, Genus Kaninote: Kaninote, Coral Genus: Coralum, Mucadenori: Mucadenori, Suzukade, Catanori, Hiramukade, Kyonohimo, Sakuranori, Nikunukade, Tambanori, Tsurutsuru,
Genus Isonohana: Nurakusa, Kronurakusa, Stinging genus, Hirakintoki: Hirakintoki, Matabou: Matabou, Kintoki: Chabokintoki, Kintoki, Matsunori, Komenori, Tosakamatsu, Aedes pine, Kakureto: Genus serrata, Genus Larva Genus Nagaobane, Funori: Hanafunori, Fukuronori, Makuhnori, Karenikusa: Kalexigusa, Tosakamomoki: Hosobanotokamodoki, Hirohanotosakamakiki, Yatsudegatomodoka, Kurosakacamodoki, Nezashinodoka, Nezashinotokada : Ezotosaka, Tsukasanori: Enashikarimenia, Otsukasanori, Hanagatakarimenia, Honooo: Hokunoo, Hikagenoito: Hikagenoito, Usuginu, Nikuhono: Nikuhono Oh, Venice genus: Venice locust, Susqueke Beni: Susqueke Beni, Okamuragusa:
Yamadakusa, Mirin genus: Mirin, Hosobamirin, Tosakanori genus: Kikutosaka, Ezonameshi: Ezonameshi, Isomokka genus: Isomocca, Yukari genus: Yukari, Hosoyukari, Ibaranori genus: Ibaranori, Saidaibara, Tachiibara, Kagiinobara, Genus genus Isanthus genus, genus Atsubanori,
Ogonori: Ogonori, Tsurushiramo, Shiramo, Ogogonori, Mizookonori, Kabanori, Tengusamodoki: Hachijotengusamodoki, Fushikenori: Fushikenori, Namiiwatake: Namiiwatake, Kaimensou:
Sponges, ssp., Ssp.
Genus: crocodile, saimi, crocodile, lotus spp. The genus Thaliosa: The genus Thalassium, Hanasakura, The genus Scrophulari: The genus Scrophulari, Scynia, The genus Hananoeda: The genus Hanaeda, The genus Hirata Goat, The genus Darus: The darth, The genus Anagalus, The genus Webagsa, Wenafkuronori
Species of the genus Fushigusa: Fushigusa, Himefushiguni, Hirohatsufushiguni, Satsumagusa: Hirawagatsugiso, Usubawaginagiso, Igis genus: Aegis, Keigisu, Kariegisu, Haneigis, Amixa, Egonori, Chinosida Family: Habutaenori, Konohanori, Suzuronori, Usveni genus: Usveni, Hasuginu: Hasujiginu, Nagakonohanori: Nagakonohanori, Suzuginu: Suzuginu, Abasibaginu, Hyasubanori: Kagusubanori, Jauresubanoli, Yasuiusobanori, Jaureusubanoli, Jaureusubanoli
Genus Ayanishi, Genus Ayanishi, Genus Ayaginu: Genus Ayaginu, Genus Dasia: Enashidazia, Genus Shimadagi: Genus Isohagi, Genus Shimadada, Genus Dazimodoki: Genus Dazimomodoki, Genus Itogusa: Moletogusa, Genus Makuri: Makuri, Yanagina, Hanayana, Rana Physcomitrella japonica, moss willow, sasabayanaginori, sozo genus: kurozozo, kobsozo, hanesozo, sozonohana, hanegusa genus: hanegusa, kaneegusa, kozanemo genus: kozanemo, isomurasaki, hosokozanemo, himegogoke genus, himegogokeo genus Genus Isomegus: Isomegusa, Suzinasugusa: Suzinasugusa, Isobashou Genus: Isobasho, Fujimatsumo Genus: Fujimatsumo, Sawtooth Lilium: Scutellaria Rihiba, genus kawa-mozuku: kawa-mozuku, aokawa-mozuku, hime-ka-mozuku, genus ideyugogome: ideyukogome, okita-mozuku genus: okiti-mozuku,
Genus genus, genus chinorimo: chinorimo, genus thysinori: chisinori).

The axle algae (Characta spp.
L. genus: L., Lychnotanus, L. genus: L., L., etc., Yellow algae (L. genus: L.).

Materials derived from animal raw materials include cockscomb extract, bovine / human placenta extract, swine / cattle stomach, duodenum or intestinal extract or its decomposed product, and swine / cattle spleen extract. Or its decomposed products, extracts of swine or bovine brain tissue, water-soluble collagen, collagen derivatives such as acylated collagen, collagen hydrolysates, elastin, elastin hydrolysates, water-soluble elastin derivatives, keratin and its decomposed products Or a derivative thereof, a silk protein and its degradation product or a derivative thereof, a pig / bovine blood cell protein degradation product (globin peptide), a pig / bovine hemoglobin degradation product (hemin, hematin, heme, protohem, heme iron, etc.), milk , Casein and its decomposition products or their derivatives, skim milk powder and its decomposition products or their derivatives, lactoferrin or its decomposition products, chicken egg ingredients Such as fish meat decomposition products.

(14) Microbial culture metabolites Yeast metabolite, yeast extract, natto metabolite, natto extract, rice ferment extract, rice bran ferment extract, euglena extract, lactic acid fermentation of raw milk and skim milk powder, and trehalose Or a derivative thereof.

(15) α-hydroxy acids glycolic acid, citric acid, malic acid, tartaric acid, lactic acid and the like.

(16) Inorganic pigments Silicic anhydride, magnesium silicate, talc, kaolin,
Bentonite, mica, titanium mica, bismuth oxychloride, zirconium oxide, magnesium oxide, zinc oxide,
Titanium oxide, calcium carbonate, magnesium carbonate, yellow iron oxide, red iron oxide, black iron oxide, gunjou, chromium oxide,
Chromium hydroxide, carbon black, calamine, etc.

(17) UV absorbing / blocking agent benzophenone derivatives (2-hydroxy-4-methoxybenzophenone, 2-hydroxy-4-methoxybenzophenone-5-sulfonic acid, 2-hydroxy-4-methoxybenzophenone-5-sulfonic acid Sodium, dihydroxydimethoxybenzophenone, dihydroxydimethoxybenzophenone-sodium sulfonate, 2,4
-Dihydroxybenzophenone, tetrahydroxybenzophenone, etc.), p-aminobenzoic acid derivatives (such as paraaminobenzoic acid, ethyl paraaminobenzoate, glyceryl paraaminobenzoate, amyl paradimethylaminobenzoate, octyl paradimethylaminobenzoate), methoxycinnamic acid Derivatives (ethyl paramethoxycinnamate, isopropyl paramethoxycinnamate, octyl paramethoxycinnamate, 2-ethoxyethyl paramethoxycinnamate, sodium paramethoxycinnamate, potassium paramethoxycinnamate,
Diparamethoxycinnamate mono-2-ethylhexanoate glyceryl, etc.), salicylic acid derivatives (octyl salicylate, salicylphenyl, homomenthyl salicylate, dipropylene glycol salicylate, ethylene glycol salicylate, myristyl salicylate, methyl salicylate, etc.), anthranilic acid derivatives (methyl anthranilate) Urocanic acid derivatives (such as urocanic acid and ethyl urocanate), coumarin derivatives, amino acid compounds,
Benzotriazole derivatives, tetrazole derivatives, imidazoline derivatives, pyrimidine derivatives, dioxane derivatives, camphor derivatives, furan derivatives, pyrone derivatives,
Nucleic acid derivatives, allantoin derivatives, nicotinic acid derivatives,
Vitamin B6 derivatives, umbelliferone, esculin,
Benzyl cinnamate, sinoxate, oxybenzone, dioxybenzone, octabenzone, slisobenzone, benzoresorcinol, arbutin, guaiazulene, shikonin, baicalin, baicalein, berberine, neoheliopan, escalol, zinc oxide, talc, kaolin.

(18) Whitening agent p-aminobenzoic acid derivative, salicylic acid derivative, anthranilic acid derivative, coumarin derivative, amino acid compound,
Benzotriazole derivatives, tetrazole derivatives, imidazoline derivatives, pyrimidine derivatives, dioxane derivatives, camphor derivatives, furan derivatives, pyrone derivatives,
Nucleic acid derivatives, allantoin derivatives, nicotinic acid derivatives,
Vitamin C or a derivative thereof, vitamin E or a derivative thereof, oxybenzone, benzophenone, arbutin, guaiazulene, shikonin, baicalin, baicalein,
Berberine and others.

(19) Tyrosinase activity inhibitor Ascorbic acid or its derivative, hydroquinone or its derivative (hydroquinone benzyl ether), kojic acid or its derivative, tocopherol or its derivative, N
-Acetyltyrosine or a derivative thereof, glutathione, hydrogen peroxide, zinc peroxide, hydroquinone monobenzyl ether, placental extract, silk extract, plant extract (mulberry, corn, warmoko, clara, mugwort, honeysuckle, yellowfin, dokudami, Matsuhod, Adlay, Pompidium, Hops, Hawthorn, Eucalyptus, Achillea millefolium, Altea, Cahi, Mankeishi, Hamamerisu, Yamaguwa, Extended life grass, Bellflower, Toshishi, Tsuzukiko, Sun dried, Mao,
Sengoku, Dokkatsu, Psycho, Bohu, Hamabofu, Ogon, Peony, Peony, Gennoshoko,
Kakkon, licorice, gobiko, aloe, ginger, safflower, green tea,
Tea, asenyaku).

(20) Melanin pigment reducing / decomposing substance: phenylmercury hexachlorophene, mercuric oxide, mercuric chloride, hydrogen peroxide, zinc peroxide, hydroquinone or a derivative thereof (hydroquinone benzyl ether) and the like.

(21) Turnover promoting action / cell activator hydroquinone, lactic acid bacteria extract, placenta extract, reishi extract, vitamin A, vitamin E, allantoin, spleen extract, thymus extract, yeast extract, fermented milk extract, plant extract (Aloe, Ogon, Horsetail, Gentian, Burdock,
Sicon, carrot, hamamelis, hop, yokunin,
Odorikosou, Assemblage, Touki, Tokinsenka, Amacha, Hypericum, Cucumber, Periwinkle,
Rosemary, parsley).

(22) Astringent succinic acid, allantoin, zinc chloride, zinc sulfate, zinc oxide, calamine, zinc p-phenolsulfonate, aluminum potassium sulfate, resorcinol, ferric chloride, tannic acid (including catechin compound) Such.

(23) Active oxygen scavenger SOD, catalase, glutathione peroxidase and the like.

(24) Antioxidants ascorbic acid or a salt thereof, stearic acid ester, tocopherol or an ester derivative thereof, nordihydroguaseletenic acid, butylhydroxytoluene (BHT),
Butylhydroxyanisole (BHA), hydroxytyrosol, parahydroxyanisole, propyl gallate, sesamol, sesamolin, gossypol and the like.

(25) Lipid peroxide production inhibitor β-carotene, plant extract (cultured sesame cells, amateur,
Hypericum, Hamamelis, Clove, Melissa, Emmeso, Birch, Sage, Rosemary, Minami Tenmi,
Ages, ginkgo, green tea) etc.

(26) Anti-inflammatory agent Ictamol, indomethacin, kaolin, salicylic acid, sodium salicylate, methyl salicylate, acetylsalicylic acid, diphenhydramine hydrochloride, d-camphor, dl-camphor, hydrocortisone, guaiazulene, camazulene, chlorpheniramine maleate, glycyrrhizin Acid or a salt thereof, glycyrrhetinic acid or a salt thereof, licorice extract, sicon extract, age extract and the like.

(27) Antibacterial, bactericidal and disinfecting agents acrinol, sulfur, calcium gluconate, chlorhexidine gluconate, sulfamine, mercurochrome, lactoferrin or its hydrolyzate, alkyldiaminoethylglycine chloride solution, triclosan, sodium hypochlorite, Chloramine T, salad powder, iodine compound,
Iodoform, sorbic acid or a salt thereof, salicylic acid, dehydroacetic acid, parahydroxybenzoic acid esters, undecylenic acid, thiamine lauryl sulfate, thiamine lauryl nitrate, phenol, cresol, p-chlorophenol, p-chloro-m-xylenol, p-chloro-m
-Cresol, thymol, phenethyl alcohol, o-
Phenylphenol, Irgasan CH3565, halocarban, hexachlorophen, chlorohexidine, ethanol, methanol, isopropyl alcohol, benzyl alcohol, ethylene glycol, propylene glycol, phenoxyethanol, chlorobutanol, isopropylmethylphenol, nonionic surfactant (polyoxyethylene lauryl ether , Polyoxyethylene nonyl phenyl ether, polyoxyethylene octyl phenyl ether, etc.), amphoteric surfactants, anionic surfactants (sodium lauryl sulfate, lauroyl sarcosine potassium, etc.), cationic surfactants (cetyltrimethylammonium bromide, benza chloride) Ruconium, benzethonium chloride, methylrosaniline chloride), formaldehyde, hexamine, Reliant Green, Malachite Green, Crystal Violet, Jarmal, Photosensitizer No. 101, Photosensitizer No. 201, Photosensitizer No. 401, N-long-chain acyl basic amino acid derivatives and their acid addition salts, zinc oxide, hinokitiol, kudin and the like.

(28) Humidifier Glycerin, propylene glycol, 1,3-butylene glycol, hyaluronic acid or its salt, polyethylene glycol, chondroitin sulfate or its salt, water-soluble chitin or chitosan derivative, pyrrolidone carboxylic acid or its salt, lactic acid Sodium, Mini Sasanishiki extract, Bacillus natto metabolite, Natto extract, etc.

(29) Inhibitors of elastase activity Diisopropyl fluorophosphate, plant extracts (Ougon, Hypericum perforatum, Clara, Mulberry leaves, Cauliflower, Gennoshoko, Comfrey, Sage, Agaricus japonicus, Bodaiju, Pomapi) and seaweed extracts.

(30) Hair Agent Selenium disulfide, alkylisoquinolinium bromide solution, zinc pyrithione, biphenamine, thianthol, castal tincture, ginger tincture, capsicum tincture, quinine hydrochloride, strong aqueous ammonia, potassium bromate, bromate Sodium, thioglycolic acid and the like.

(31) Antiandrogens Estrogen (estrone, estradiol, ethinylestradiol, etc.), isoflavones, oxendrones and the like.

(32) Peripheral vascular blood flow promoter Vitamin E or a derivative thereof, assembly extract, garlic extract, carrot extract, aloe extract, gentian extract, touki extract, cepharanthin, carpronium chloride, minoxidil and the like.

(33) Local stimulants Pepper tincture, vanylamide nonylate, tincture tincture, tincture tincture, peppermint oil, l-menthol, camphor, benzyl nicotinate and the like.

(34) Metabolic activator Photosensitizer No. 301, hinokitiol, pantothenic acid or a derivative thereof, allantoin, placenta extract, biotin, glyceride pentadecanoate and the like.

(35) Antiseborrheic agents pyridoxine or its derivatives, sulfur, vitamin B6 and the like.

(36) Keratolytic agents Resorcin, salicylic acid, lactic acid and the like.

(37) Oxidizing agent Hydrogen peroxide solution, sodium persulfate, ammonium persulfate, sodium perborate, urea peroxide, sodium percarbonate, sodium tripolyphosphate, sodium bromate, potassium bromate, pyrroline peroxide Sodium acid, sodium orthophosphate, sodium silicate hydrogen peroxide adduct, sodium sulfate sodium chloride hydrogen peroxide adduct, β-tyrosinase enzyme solution, mushroom extract and the like.

(38) Hair remover strontium sulfate, sodium sulfide, barium sulfide,
Inorganic reducing agents such as calcium sulfide; thioglycolic acid or salts thereof (calcium thioglycolate, sodium thioglycolate, lithium thioglycolate, magnesium thioglycolate, strontium thioglycolate) and the like.

(39) Hair swelling agent Ethanolamine, urea, guanidine and the like.

(40) Dyes 5-aminoorthocresol, 2-amino-4-nitrophenol, 2-amino-5-nitrophenol, 1-
Amino-4-methylaminoanthraquinone, 3,3'-
Iminodiphenol, 2,4-diaminophenoxyethanol hydrochloride, 2,4-diaminophenol hydrochloride, toluene-2,5-diamine hydrochloride, nitroparaphenylenediamine hydrochloride, paraphenylenediamine hydrochloride, N-phenylparaphenylenediamine hydrochloride, meta-hydrochloride Phenylenediamine, orthoaminophenol, N-phenylparaphenylenediamine acetate, 1,4-diaminoanthraquinone, 2,6-diaminopyridine, 1,5-dihydroxynaphthalene, toluene-2,5-diamine, toluene-
3,4-diamine, nitroparaphenylenediamine, paraaminophenol, paranitroorthophenylenediamine, paraphenylenediamine, paramethylaminophenol, picramic acid, sodium piclaminate, N,
N'-bis (4-aminophenyl) -2,5-diamino-1,4-quinonediimine, 5- (2-hydroxyethylamino) -2-methylphenol, N-phenylparaphenylenediamine, metaaminophenol, meta Phenylenediamine, 5-aminoorthocresol sulfate, 2-amino-5-nitrophenol sulfate, orthoaminophenol sulfate, orthochloroparaphenylenediamine sulfate, 4,4'-diaminodiphenylamine sulfate, 2,4-diaminophenol sulfate, sulfuric acid Toluene-2,5-
Diamine, nitroparaphenylenediamine sulfate, paraaminophenol sulfate, paranitroorthophenylenediamine sulfate, paranitrometaphenylenediamine sulfate, paraphenylenediamine sulfate, paramethylaminophenol sulfate, metaaminophenol sulfate, metaphenylenediamine sulfate, catechol, diphenylamine , Α-naphthol, hydroquinone, pyrogallol, phloroglucin, gallic acid, resorcin, tannic acid, 2-hydroxy-5-nitro-2 ', 4'-diaminoazobenzene-
Sodium 5'-sulfonate, hematein and the like.

(41) Flavors Natural animal flavors such as musk, civet, castorium, ambergris, anise essential oil, angelica essential oil, ylang-ylang essential oil, iris essential oil, fennel essential oil, orange essential oil, cananga essential oil, caraway essential oil, cardamom essential oil, Guaiac wood essential oil, cumin essential oil, black letter essential oil, cinnamon essential oil, cinnamon essential oil, geranium essential oil, copaiba balsam essential oil, coriandel essential oil, perilla essential oil, cedarwood essential oil, citronella essential oil, jasmine essential oil, ginger grass essential oil, cedar essential oil, spearmint essential oil, western Mentha essential oil, Great Fengxiang essential oil, Tuberose essential oil, T-shape essential oil, Orange flower essential oil, Winter green essential oil, Truval sam essential oil, Batturi essential oil, Rose essential oil, Palmarosa essential oil, Cypress essential oil, Hiba essential oil,
Sandalwood essential oil, Petit glen essential oil, Bay essential oil, Vetiva essential oil, Bergamot essential oil, Peruvian balsam essential oil, Boad rose essential oil, Camphor essential oil, Mandarin essential oil, Eucalyptus essential oil, Lime essential oil, Lavender essential oil, Linaloe essential oil, Lemongrass essential oil, Lemon essential oil, Rosemary Vegetable flavors such as essential oils, Japanese peppermint essential oils, and other synthetic flavors.

(42) Dyes and Colorants Red Cabbage Dye, Red Rice Dye, Akane Dye, Anato Dye, Ikasumi Dye, Turmeric Dye, Endu Dye, Krill Dye, Persimmon Dye, Caramel, Gold, Silver, Gardenia Dye, Corn Dye , Onion pigment, tamarind pigment, spirulina pigment, buckwheat whole plant pigment, cherry pigment, laver pigment, hibiscus pigment, grape juice pigment, marigold pigment, purple potato pigment, purple yam pigment, lac pigment, rutin, etc.

Other hormones, sequestering agents,
pH adjuster, chelating agent, antiseptic / antibiostatic agent, cooling agent, stabilizer, emulsifier, animal / vegetable protein or its degradation product, animal / vegetable polysaccharide or its degradation product, animal / vegetable glycoprotein or Decomposed products, anti-inflammatory and anti-allergic agents, wound treatment agents,
Bubble / foaming agents, thickeners, oral agents, deodorants / deodorants, bittering agents, seasonings, enzymes, etc. are expected to be added, and combined or synergistic effects can be expected. it can.

The melanin production inhibitor, active oxygen scavenger, lipid peroxide production inhibitor, antiallergic agent, histamine release inhibitor, antitrapping agent or cosmetic composition of the present invention can be in any form. Yes, it can be compounded and used in the form of capsules, powders, granules, solids, liquids, gels, foams, emulsions, creams, ointments, sheets and the like.

Specifically, for example, basic cosmetics such as external preparations, lotions, emulsions, creams, ointments, lotions, oils, packs, facial cleansers and skin cleansers, depilatory agents, depilatory agents, aftershave lotions , Pre-show lotion, shaving cream, shampoo, rinse,
Hair treatments, hair styling agents, perm agents, hair tonics, hair dyes, hair growth / hair restorations, etc., makeup cosmetics such as foundations, lipsticks, blushers, eye shadows, eyeliners, mascaras, perfumes, bath agents , Other, toothpaste, mouth freshener / gargle, deodorant,
It can be applied to various products such as deodorant, sanitary cotton, wet tissue, and can be used for general food and drink.

The method of the present invention for adding to the melanin production inhibitor, active oxygen scavenger, lipid peroxide production inhibitor, antiallergic agent, histamine release inhibitor, antitrapping agent or cosmetic composition of the present invention. May be added in advance or may be added during the production, and may be appropriately selected in consideration of workability.

[0088]

EXAMPLES The present invention will be described below with reference to production examples, test examples, and prescription examples, but the present invention is not limited to these examples.

(Production Example 1) 100 g of rhubarb was purified water (about 80
C.) for about 5 hours, followed by filtration to obtain about 1.0 kg of an extract (dry solid content: about 0.3 to 2.5% by weight).

(Production Example 2) 100 g of rhubarb is immersed in a 50% ethanol solution, extracted at room temperature for 5 days and nights, and then filtered to obtain about 1.0 kg of an extract (dry solid content: about 0.3 to 2.5% by weight). .

(Production Example 3) 100 g of rhubarb in 70% ethanol solution or 30% 1,3-butylene glycol solution, or 60%
It is immersed in a propylene glycol solution or purified water (about 30 ° C.), extracted at room temperature for 5 days and nights, and then filtered to obtain about 1.0 kg of an extract (dry solid content: about 0.3 to 3.0% by weight).

(Test 1) Melanin Production Inhibition Test The present inventor evaluated melanin production inhibitory action based on B16 melanoma cells.

[Test Method and Evaluation Method] B16 melanoma cells pre-cultured for 24 hours are transferred to a fresh medium, and a 0.5% sample is added thereto, followed by culturing for 3 days. Next, the cultured cells are treated with trypsin, dissolved by heating in a 1N-NaOH, 10% DMSO solution, and the absorbance at 420 nm is measured. In addition, instead of the sample, distilled water was used as a blank, and cells to which the sample was added at the same time were subjected to an MTT reduction method (Tim Mosmann; Journal).
al. Immunological Methods, p55-63 (1983)), the MTT reduction activity of the sample-loaded cells was calculated using the MTT reduction activity of blank cells as one unit.
The amount of melanin in the sample was calculated as absorbance / MTT reducing activity (1 unit), and the inhibition rate (%) of the amount of melanin produced by the blank cells was determined by the following equation (Equation 1). The results are shown in FIG. "Sample" The sample for the melanin production inhibition test was the extract obtained in Production Example 2 of the present invention (adjusted to a solid content of 0.5%).
Was used for the test. As a comparative sample, arbutin (manufactured by Sigma) was prepared under the same conditions and used for the test.

<Equation 1> Melanin production inhibition rate (%) = ｛1
-(Sample melanin amount / blank melanin amount) x 100

(Test Results) As shown in FIG. 1, it was confirmed that the rhubarb extract of the present invention significantly suppressed the production of melanin pigment and had a high melanin production inhibitory action.
In addition, it has been confirmed that it has a higher melanin production inhibitory effect than arbutin, and can be used as a whitening agent.

(Test 2) Elimination of active oxygen (SOD-like activity)
Tests In recent years, many diseases and diseases induced by active oxygen have been reported, and it has been pointed out that removal / elimination of active oxygen (SOD activity) leads to prevention of tissue damage. In this test, the extract obtained in Production Example 2 was tested for its ability to eliminate active oxygen generated by the xanthine-xanthine oxidase system using the NBT method of the Imana et al. (Co., Ltd.).

"Test method and evaluation method" a. After distilling off the solvent from the sample extract under reduced pressure, the solid content concentration in purified water
It was redissolved to 0.05% and used for the test. b. Measurement of active oxygen quenching ability In a small test tube, 2.5 mL of 0.05 M sodium carbonate buffer (pH 10.2),
0.75 mM nitro blue tetrazolium (NBT), 3.0 mM
Xanthine, 3.0 mM disodium ethylenediaminetetraacetate, 0.15 W / V% bovine serum albumin, and 0.1 mL each of a sample solution (the solvent for the control) were added, and the mixture was kept at 25 ° C. for 10 minutes. Adjust so that the absorbance change becomes about 0.3 / 20 min).
The absorbance at 60 nm was measured. In addition, a sample containing purified water instead of a sample was used as a control, and a blank containing a reaction stopping solution was set for each sample and control before adding xanthine oxidase. The results were shown in FIG.

<Equation 2> Active oxygen scavenging rate (%) = {1− (sample OD value−flank (sample) OD value) / (control OD value−flank (control) OD value)} ×
100

(Test Results) As shown in FIG. 2, it was confirmed that the rhubarb extract of the present invention had an excellent active oxygen scavenging effect.

(Test 3) Lipid Peroxide Production Inhibition Test Lipid peroxide is obtained by adding a peroxide, mainly hydroperoxide, to an unsaturated fatty acid which is a component of lipid. These lipid peroxides cause damage to cell membranes in vivo, inactivate various enzymes, denature biological proteins, etc., and adversely affect biological tissues. As a result, it is thought that it promotes aging and leads to diseases such as cancerous changes. In the skin, the accumulation of lipid peroxides caused by the peroxidation of sebum causes changes in the cell membrane and mitochondrial function of the skin, causing liver spots, melasma, primary irritant dermatitis, atopic dermatitis It is said to be one of the causes of various skin diseases such as skin aging (wrinkles, senile pigmentation, etc.) and rough skin. Inhibition of lipid peroxidation is regarded as important in dermatology. . In this test, the TBA method (Analytical, Biochemistry. Vol. 95, pp. 351 to 358) was used to evaluate the effect of the iron-ascorbic acid system on the peroxidation of epidermal lipids and squalene in the extract obtained in Production Example 1. (1979)).

[Test Method and Evaluation Method] Squalene was added to a 1% aqueous solution of polyoxyethylene (10) octyl phenyl ether at a concentration of 0.1%, ammonium sulfate 8M and ascorbic acid at a concentration of 38M, and dissolved. Take in a small test tube. To this is added 0.1 mL of the sample solution, placed in a thermostat at 37 ° C., and left for 3 hours. After completion of the reaction, add 1 mL of the reaction solution.
Take 0.01 mL of 4.5% dibutylhydroxytoluene and 0.67
% 2-thiobarbituric acid, 15% acetic acid aqueous solution (pH 3.5) 1m
Add L and heat at 95 ° C for 1 hour. After cooling, add 4 mL of butanol containing 15% methanol, shake well, and centrifuge. The absorbance at 534 nm of this butanol layer was measured and defined as the amount of lipid peroxide. A sample containing purified water in place of the sample was used as a control, an unreacted blank was set for each sample and the control, and the lipid peroxide production inhibition rate was determined by the following equation (Equation 3). Indicated. "Sample" A sample for the lipid peroxide production inhibition test was used for the test using the extract (solid content: adjusted to 0.1%) obtained in Production Example 2 of the present invention. As a sample for comparison, dl
An aqueous solution of -α-tocopherol (manufactured by Kishida Chemical) was prepared under the same conditions and used for the test.

<Equation 3> Lipid peroxide production inhibition rate (%) = ｛1− (sample OD value−flank (sample) OD value) / (control OD value−flank (control) OD)
Value) x 100

(Test Results) As shown in FIG. 3, it was confirmed that the rhubarb extract of the present invention had a stronger inhibitory effect on lipid peroxide production than the dl-α-tocopherol aqueous solution. Therefore, the rhubarb extract of the present invention can be used as an antioxidant.

(Test 4) Histamine Release Inhibition Test In an immediate allergic reaction, histamine and other chemical mediators are released from mast cells or basophils sensitized in the second stage. Therefore, a substance that suppresses histamine release can be expected to have an antiallergic effect. In this test, histamine releasing reagent co
Test method for releasing histamine with mpound48 / 80 (J. Soc. C
osmet.Japan, Vol.25, No.4, P.246 (1992))
The extract obtained in Production Example 2 was examined.

"Test Method and Evaluation Method" a. Sample The sample for the histamine release inhibition test is Production Example 2 of the present invention.
Using the extract (solid content concentration: adjusted to 0.5%) obtained in the above, it was subjected to a test. As a comparative sample, cromolyn (manufactured by Sigma) was prepared under the same conditions and used for the test. b. Measurement of the amount of free histamine A 0.2 mL sample was added to 1.2 mL of mast cell suspension collected from the intraperitoneal cavity of a rat (Slc: Wister male rat, about 4 to 9 weeks old).
And compound48 / 80 were added to a final concentration of 1 μg / mL, and incubated at 37 ° C. for 15 minutes. After stopping the reaction by cooling on ice, the reaction solution was centrifuged, the histamine released from the supernatant was extracted and purified, and the color was developed with o-phthaldialdehyde. The histamine release inhibition rate was determined by the following equation (Equation 4), and the results are shown in FIG.

<Equation 4> Histamine release inhibition rate (%) = ｛1− (AC / B−)
C)｝ × 100 A: Fluorescence intensity of histamine released when a histamine releasing agent was added in the presence of a sample in mast cells B: Fluorescence intensity of histamine released when a histamine releasing agent was added to mast cells C: Fluorescence intensity of histamine naturally released from mast cells (A, B and C are measured values minus blind values)

(Test Results) As shown in FIG. 4, the rhubarb extract of the present invention was confirmed to have a higher histamine release inhibitory action than cromolyn, and can be used as an antiallergic agent.

(Test 5) Anti-Complement Activity Test The complement system plays an important role in the immediate allergy involving antibodies other than the IgE antibody. Substances that affect the complement system include allergies,
It may affect image formation such as inflammation. In this test, the extract obtained in Production Example 2 was examined using an anti-complement activity measurement method using the hemolytic reaction of sensitized red blood cells as an index.

"Test Method and Evaluation Method" a. Gelatin / veronal buffer (GVB ²⁺ ) 1.7 g of sodium chloride, 0.115 g of barbital, 0.075 g of sodium barbital, 0.015 g of calcium chloride, 0.010 g of magnesium chloride
g, 0.2 g of gelatin and 100 mL of purified water were adjusted to pH 7.5, and the total amount was adjusted to 200 mL with purified water. b. Sheep red blood cell (SRBC) suspension Sheep blood is centrifuged at 2,000 rpm for 5 minutes, washed three times with physiological saline, and GVB ²⁺ is added to the sediment to prepare a 10% SRBC suspension, which is finally SRBC 3.05 to 0.25 mL of suspension
When complete hemolysis was performed by adding 0.1 mL of a 0.1% sodium carbonate solution, the absorbance at 540 nm was adjusted to 0.455. c. Anti-SRBC Mouse Serum 0.2 mL of 10% SRBC suspension was injected intravenously into the tail of IVCS male mice, 4 days later, blood was collected, serum was separated and GVB
^It was diluted 40 times with ²⁺ and used. d. Complement Guinea pig fresh serum was diluted 20-fold with GVB ²⁺ and used. e. Measurement of anti-complement activity 0.1 mL of sample in 0.5 mL of GVB ²⁺ and 0.5 mL of anti-SRBC serum, S
After 0.25 mL of the RBC suspension and 0.25 mL of the complement solution were sequentially added, the reaction was carried out in a thermostat at 37 ° C. for 60 minutes. 10 in ice water
After leaving the reaction to stand for
After centrifugation for 0 minutes to separate unlysed red blood cells, the OD value of the supernatant at 540 nm was measured. A sample containing purified water instead of a sample was used as a control, a blank containing no serum was set for each sample and control, and the complement activity inhibition rate (= anti-complement activity) was calculated by the following equation (Equation 5). And the results are shown in FIG. "Sample" The sample for the anti-complement activity test was prepared in Production Example 2 of the present invention.
Using the extract (solid content concentration: adjusted to 0.1%) obtained in the above, it was subjected to a test. As a comparative sample, dipotassium glycyrrhizinate (manufactured by Alps Chemical Industries, Ltd.) was prepared under the same conditions and used for the test.

<Equation 5> Complement activity inhibition rate (%) = {1− (sample OD value−flank (sample) OD value) / (control OD value−flank (control) OD value)} ×
100

(Test Results) As shown in FIG. 5, the rhubarb extract of the present invention was confirmed to have an excellent anti-complement activity compared to dipotassium glycyrrhizinate, and can be used as an antiallergic agent.

(Test 6) Safety test (1) Primary skin irritation test The rhubarb extract obtained in Production Examples 1 to 3 was prepared with purified water so as to have a dry solid concentration of 0.5%. Japanese white rabbit with female shaving (female, 3 per group, weight around 2.3kg)
Was applied to the skin. At 24, 48 and 72 hours after application, evaluation was performed using erythema and edema as indices based on the criteria of Draize. As a result, no erythema and edema were observed in all animals, and it was judged that there was no problem with regard to primary skin irritation.

(Test 7) Safety Test (2) Skin Cumulative Irritation Test Similarly, the rhubarb extract obtained in Production Examples 1 to 3 was prepared with purified water so that the dry solid content concentration was 0.5%. , Hartley guinea pigs with shaved backs (female, 3 per group,
0.5 mL / animal was applied to the skin once a day, 5 times a week, on the skin of about 320 g in weight). Application was performed over two weeks and shaving was performed on the last application day of each week. Evaluation was performed using erythema and edema as indices based on the criteria of Draize on each application day and the day after the last application day. As a result, no erythema or edema was observed in any of the animals for 2 weeks, and it was judged that there was no problem with respect to the cumulative skin irritation.

(Test 8) Safety test (3) Acute toxicity test A powder obtained by similarly concentrating and drying the rhubarb extract obtained in Production Examples 1 to 3 (dry solid content: 1.0%)
Was orally administered to ddy mice (male and female, 5 mice per group, 5 weeks of age) fasted for 4 hours before the test,
The appearance and degree of toxicity symptoms were observed over time. As a result, no abnormality was observed in all mice for 14 days,
The dissection results were normal. Therefore, LD50 is 2,000m
g / kg or more.

(Prescription example) Production of melanin production inhibitor, active oxygen scavenger, lipid peroxide production inhibitor, antiallergic agent, histamine release inhibitor, anticaptor active agent or cosmetic composition According to the above evaluation results In the following, the formulation example is shown,
Each formulation example may be one manufactured by a usual method in the manufacture of each product, and only the compounding amount is shown. Further, the present invention is not limited to these.

(Formulation Example 1) Emulsion Weight% 1. Squalane 8.0 2. Jojoba oil 7.0 3. Cetyl alcohol 1.5 4. Glycerin monostearate 2.0 5. Polyoxyethylene (20) cetyl ether 3.0 6. Polyoxyethylene (20 ) Soorbitan monooleate 2.0 7.1,3-butylene glycol 1.0 8. Glycerin 2.0 9. Rhubarb 50% ethanol extract 5.0 10. Preservative (paraoxybenzoate) qs 11. perfume qs 12. Purified water 100

(Formulation Example 2) Cosmetic oil weight% 1. Liquid paraffin 30.0 2. Squalane 20.0 3. Olive oil 20.0 4. Isopropyl palmitate 10.0 5. Rhubarb hot water extract 3.0 6. Aloe vera pressed extract 1.0 7. Turmeric heat Water extraction extract 1.0 8. Butyl hydroxyanisole 0.1 9. Preservative (benzalkonium chloride) proper amount 10. Perfume proper amount 11. Purified water 100 residue

(Formulation Example 3) Flexible lotion% by weight 1. Glycerin 5.0 2.1, 3-butylene glycol 5.0 3. Polyoxyethylene sorbitan monolaurate (20E.O) 1.0 4. Ethanol 15.0 5. Extraction of rhubarb 50% ethanol Liquid 3.0 6. Echinashi 30% ethanol extract 1.0 7. Emisodium 30% 1,3-butylene glycol extract 1.0 8. Antibacterial and preservative (thiamine lauryl sulfate) qs 9. perfume qs 10. Purified water 100

(Formulation Example 4) Astringent lotion weight% 1. Sorvitol 2.0 2. POE (20) oleyl alcohol 1.0 3. Ethanol 15.0 5. Rhubarb 50% 1,3-butylene glycol extract 2.0 6. Hamamelis 30% ethanol Extract 1.0 7. Allantoin 0.2 8. Astringent (zinc sulfocarbonate) 0.2 9. Antibacterial and preservative (thiamine lauryl sulfate) qs 10. perfume qs 11. Purified water 100

(Formulation Example 5) Two-layer lotion (liquid to liquid type) weight% 1. squalane 8.0 2. POE sorbitan tetraoleate 0.3 3. sorbit 1.0 4. ethanol 15.0 5. rhubarb 50% propylene glycol extraction Solution 2.0 6. Eucalyptus 30% ethanol extract 1.0 7. Ascorbic acid 0.2 8. Astringent (sodium sulfocarbonate) 0.2 9. Preservative (phenoxyethanol) qs 10. Fragrance qs 11. Purified water 100

(Formulation Example 6) Carmine lotion (liquid to solid) wt% 1. Glycerin 3.0 2.1,3-butylene glycol 5.0 3. Ethanol 15.0 4. Iron oxide (Bengara) 0.2 5. Zinc oxide 0.5 6. Kaolin 2.0 7. Rhubarb 50% propylene glycol extract 2.0 8. Placenta extract 1.0 9. Camphor 0.2 10. Phenol 0.03 11. Preservative (photosensitizer No. 201) qs 12. spices qs 13. Purified water 100

(Formulation Example 7) Peel-off pack weight% 1. Glycerin 5.0 2. Propylene glycol 4.0 3. Polyvinyl alcohol 15.0 4. Ethanol 8.0 5. Polyoxyethylene glycol 1.0 6. Pantothenyl ethyl ether 1.0 7. Rhubarb 50% ethanol Extract 3.0 8. Seaweed 50% ethanol extract 1.0 9. Appropriate amount of perfume 10. Appropriate amount of preservative (p-hydroxybenzoate) 11. Residual to 100 purified water

(Formulation Example 8) Cold cream weight% 1. Salicone beeswax 11.0 2. Liquid paraffin 22.0 3. Lanolin 10.0 4. Olive oil 15.0 5. Borax 0.5 6. Chamomile 50% 1,3-butylene glycol extract 1.0 7 .Rice 50% 1,3-butylene glycol extract 2.0 8. Preservative (acrinol) 0.1 9. Appropriate amount of flavoring agent 10. Purified water 100

(Formulation Example 9) Face Wash Cream% by Weight 1. Myristic acid 25.0 2. Stearic acid 5.0 3. Tallow fatty acid 5.0 4. Propylene glycol 10.0 5. Potassium hydroxide 6.0 6. Coconut oil fatty acid diethanolamide 6.0 7. Wild thyme 50% 1,3-butylene glycol extract 1.0 8. Rhubarb 50% 1,3-butylene glycol extract 2.0 9. Dipotassium glycyrrhetinate 1.0 10. Lactoferrin solution 0.1 11. Preservative (salicylic acid) 0.1 12. Fragrance Appropriate amount 13 .Remaining amount of purified water 100

(Formulation Example 10) Body soap weight% 1. Potassium laurate 15.0 2. Potassium myristate 5.0 3. Propylene glycol 5.0 4. Rhubarb 70% 1,3-butylene glycol extract 0.5 5. Touki 30% 1, 3-butylene glycol extract 0.5 6. Horse chestnut 30% 1,3-butylene glycol extract 0.5 7. Polyethylene powder 0.5 8. Bacillus natto metabolite 0.5 9. Amino acids (glycine, glutamine, etc.) 0.5 10. Preservative (undecylene) Acid, phenol) Appropriate quantity 11. pH adjuster Appropriate quantity 12. Purified water 100 residue

(Formulation Example 11) Sunscreen cosmetics (O / W type)% by weight 1. Oxybenzone 2.0 2. Octyl paramethoxycinnamate 5.0 3. Squalane 10.0 4. Vaseline 5.0 5. Stearyl alcohol 3.0 6. Stearic acid 3.0 7. Glyceryl monostearate 2.0 8. Polyethyl acrylate 1.0 9.1,3-butylene glycol 6.0 10. Disodium edetate 0.1 11. Triethanolamine 99% 1.0 12. Titanium dioxide 5.0 13. Rhubarb 30% 1,3- Butylene glycol extract 0.5 14. Birch 50% ethanol extract 0.5 15. Preservative (paraben) appropriate amount 16. Purified water 100 residue

(Formulation Example 12) Sunscreen cosmetics (oil type)% by weight 1. Liquid paraffin 70.0 2. Ethyl paraaminobenzoate 1.0 3. Tetrahydroxybenzophenone 1.0 4. Cetyl octanoate 25.0 5. Rhubarb 30% 1,3 -Butylene glycol extract 0.5 6. Timpi 50% ethanol extract 0.5 7. Antioxidant (butylhydroxytoluene)

(Formulation Example 13) Shampoo wt% 1. Triethanolamine lauryl sulfate 5.0 2. Sodium polyoxyethylene lauryl ether sulfate 12.0 3.1,3-butylene glycol 4.0 4. Diethanolamide laurate 2.0 5. Disodium edetate 0.1 6. Rhubarb 50% propylene glycol extract 2.0 7. Rosemary 30% ethanol extract 1.0 8. Collagen hydrolyzate 1.0 9. Antibacterial and preservative (thiamine lauryl sulfate) qs 10. pH adjuster qs 11. Fragrance qs 12.Remaining with 100 purified water

(Formulation Example 14) Rinse weight% 1. Stearyl trimethylammonium chloride 2.0 2. Cetostearyl alcohol 2.0 3. Polyoxyethylene lanolin ether 3.0 4. Propylene glycol 5.0 5. Rhubarb 50% ethanol extract 1.0 6. Trehalo- Solution 1.0 7. Hydrolyzed silk solution 1.0 8. Peony skin 50% ethanol extract 0.5 9. Antibacterial and preservative (benzalkonium chloride) qs 10. qs flavor qs 11. Purified water 100

(Formulation Example 15) Hair liquid% by weight 1. Ethanol 29.0 2. Polyoxypropylene butyl ether phosphoric acid 10.0 3. Polyoxypropylene monobutyl ether 5.0 4. Triethanolamine 1.0 5. Rhubarb hot water extract 1.0 6. Parietaria 50% methanol extract 1.0 7. Seaweed 50% 1,3-butylene glycol extract 1.0 8. Keratin decomposition solution 1.0 9. Antibacterial and preservative (paraben, benzalkonium chloride) qs 10. spice qs 11. purified water 100 And the rest

(Formulation Example 16) Hair tonic weight% 1. Ethanol 40.0 2. Ethyl oleate 1.0 3. Polyoxyethylene (40) hydrogenated castor oil 2.0 4. Rhubarb 50% 1,3-butylene glycol extract 1.0 5. Sodium hyaluronate solution 1.0 6. Carboxymethyl chitin solution 1.0 7. Whey solution 1.0 8. Mucopolysaccharide solution 1.0 9. Antibacterial and preservative (paraben) 0.1 10. Appropriate perfume 11. Purified water 100

(Formulation Example 17) Granule bath agent weight% 1. Sodium bicarbonate 58.0 2. Anhydrous sodium sulfate 30.0 3. Borax 3.0 4. Rhubarb 70% ethanol extract 4.0 5. Chimpi 50% ethanol extract 2.0 6. 70% Ethanol extract 1.0 70. Egg extract 70% Ethanol 1.0 8. Orange juice 1.0

(Formulation Example 18) Coating protective agent A gauze or liniment cloth is impregnated with a formulation solution obtained by mixing an appropriate amount of rhubarb 30% ethanol extract, antibiotics, anti-inflammation, etc., and attached to the wound. Alternatively, a rhubarb 30% ethanol extract may be directly sprayed locally and covered with gauze or the like.

(Test 9) Use effect test The effect when the cosmetic composition of the present invention was actually used was examined. Use test is for those who are worried about spots, freckles, dark and dark, and those who are worried about dry skin, glossy and firm skin 3
The test was carried out by applying an appropriate amount of the emulsion of Formulation Example 1 to the face over three months, twice a day, in the morning and at night, after washing the face twice a day. As a control, a mixture prepared by removing the respective plant extracts of the present invention from the emulsion in the same manner was used. The evaluation was performed according to the following criteria. The results are shown in Tables 1 and 2, and the numbers in the table represent the number of persons. No one complained of abnormal skin during the use period.

"Effect of spots and freckles & skin color improvement" Effective: White spots and freckles and skin color were reduced. Slightly effective: White spots and freckles and skin color were slightly reduced. Ineffective: No change from before use.

[0136]

"Effect of improving skin feel" Efficacy: Dry skin and skin gloss / tension increased, and skin was improved. Slightly effective: Dry skin and skin gloss / tension increased slightly, and skin was improved. Ineffective: No change from before use.

[0138]

(Test Results) As shown in Tables 1 and 2, the emulsion containing the rhubarb extract of the present invention significantly improves dry skin, gives the skin a shine and firmness, and also removes stains, freckles and skin. Was also white, and it was confirmed that the color was reduced.

(Test 10) Use effect test The effect when the skin care cosmetic composition of the present invention was actually used was examined. The use test is for people suffering from eczema and rough skin.
The washing was performed twice a day, in the morning and at night, by applying an appropriate amount of the emulsion of Formulation Example 1 to the face over three months after washing the face. As a control, a mixture prepared by removing the respective plant extracts of the present invention from the emulsion in the same manner was used. The evaluation was performed according to the following criteria. The results are shown in Table 3 and the numerical values in the table represent the number of persons. No one complained of abnormal skin during the use period.

"Beautiful skin effect" Efficacy: Eczema and rough skin were improved. Somewhat effective: Eczema and rough skin were slightly improved. Ineffective: No change from before use.

[0142]

(Test Results) As shown in Table 3, it was confirmed that the emulsion containing the rhubarb extract of the present invention improved eczema and rough skin.

Industrial Applicability The melanin production inhibitor, active oxygen scavenger, lipid peroxide production inhibitor, antiallergic agent, histamine release inhibitor, anticaptor active agent or cosmetic composition containing rhubarb extract of the present invention Has an excellent inhibitory action on melanin production, a whitening effect is confirmed, and active oxygen is also significantly eliminated / suppressed, and the production of lipid peroxide is suppressed. Furthermore, the effect of suppressing histamine release was confirmed. And to reduce stains and freckles on the skin. or,
It can improve skin inflammatory diseases (for example, redness, edema, eczema, etc.), rough skin, and dry skin, and can also give the skin a gloss and firmness, and is safe for humans and animals. still,
The present invention can be used for other general foods and drinks.

[Brief description of the drawings]

FIG. 1 is a graph showing the inhibition rate of the rhubarb extract of the present invention with respect to the amount of melanin produced.

FIG. 2 is a graph showing the active oxygen scavenging effect of rhubarb extract of the present invention.

FIG. 3 is a graph showing the action of the rhubarb extract of the present invention to inhibit lipid peroxide production.

FIG. 4 is a graph showing the histamine release inhibitory effect of a rhubarb extract of the present invention.

FIG. 5 is a graph showing the anti-capturing activity of the rhubarb extract of the present invention.

──────────────────────────────────────────────────続 き Continued on the front page (51) Int.Cl. ⁷ Identification symbol FI Theme coat ゛ (Reference) A61P 37/08 A61K 31/00 637E 39/06 639C 43/00 643F A61K 35/78 643D 35/78 EF Terms (reference) 4C083 AA072 AA082 AA111 AA112 AA122 AB032 AB152 AB212 AB232 AB242 AB312 AB352 AB442 AC012 AC022 AC072 AC102 AC122 AC132 AC152 AC182 AC212 AC242 AC312 AC342 AC352 AC422 AC432 AC442 AC472 AC482 AC532 AC542 AC582 AC642 AC682 AD042 AD312 AD322 AD332 AD432 AD442 AD452 AD512 AD532 AD642 BB51 CC01 CC04 CC05 CC07 CC19 CC23 CC25 CC32 CC37 CC38 CC39 DD05 DD12 DD16 DD23 DD30 DD31 DD33 EE12 EE16 EE17 EE22 4C088 AA12 AB12 AB14 AB25 AB26 AB38 AB41 AB43 AB57 AB58 AB89

Claims (7)

[Claims] 1. A melanin production inhibitor comprising a rhubarb extract. 2. An active oxygen scavenger comprising a rhubarb extract. 3. A lipid peroxide production inhibitor comprising a rhubarb extract. 4. An antiallergic agent comprising a rhubarb extract. 5. A histamine release inhibitor comprising a rhubarb extract. 6. An anti-complementary active agent comprising a rhubarb extract. 7. A melanin production inhibitor, an active oxygen scavenger, a lipid peroxide production inhibitor, an antiallergic agent, a histamine release inhibitor, or an anti-captive activator according to any one of claims 1 to 6, A cosmetic composition comprising at least one kind.