JP2002205933A - Cosmetic composition containing extract of orchidaceous plant - Google Patents

Abstract

PROBLEM TO BE SOLVED: To obtain a new and safe antioxidant, humectant or cosmetic composition having ameliorating effects on freckles, wrinkles and a skin color, ameliorating a dry skin and a chapped skin, imparting bloom and firmness to the skin and having skin care effects and antiaging effects effective for a dryness, a crumbling, a split hair, a cut hair, lustering, or the like, of the hair. SOLUTION: The antioxidant, the humectant and the cosmetic composition comprise each one or more kinds of plant extracts selected from the plants belonging to the family Orchidaceae.

Description

DETAILED DESCRIPTION OF THE INVENTION

[0001]

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to a novel cosmetic effect of one or more plant extracts selected from orchids and the application to cosmetic compositions based thereon.

[0002]

2. Description of the Related Art In recent years, the generation of active oxygen in vivo
Various effects (diseases) caused by it have been reported.
You. Generally, this active oxygen is also called Activated oxygens.
Barred, O _Two ^-, H_TwoO_Two, OH, chemiluminescence,
All have strong bactericidal action and are involved in the self-defense of living organisms
It is considered an important substance. For example, bacteria, virus
External enemies (antigens) such as viruses and foreign substances enter the living body
Then, first, phagocytes in blood, neutrophils, monocytes,
Lophage initiates phagocytosis, then into the phagocytic endoplasmic reticulum
Active oxygen is produced to dissolve engulfed foreign matter
You. This active oxygen affects the dissolution of phagocytic foods, while
Indirectly has a bactericidal action against external enemies such as bacteria and foreign substances
And play a role in protecting the living body from external enemies.

[0003] However, if the active oxygen for self-defense is excessively produced and secreted, even normal cells can be lysed and stimulated, resulting in various damage reactions.
Recently, many diseases and diseases induced by active oxygen have been reported. For example, fats and oils such as cholesterol in the blood are oxidized by active oxygen, and vascular disorders due to arteriosclerosis in the brain and heart (stroke, myocardial infarction, etc.)
And blood flow impairment due to a thrombus or the like at the time of cerebral trauma, or ischemic state (oxygen deficiency) in blood vessels due to sudden transient atrophy.

[0004] In particular, since the skin is an organ that is in direct contact with the outside world, it is easily affected by external environmental factors such as ultraviolet rays.
It is known that various diseases are caused by the active oxygen generated thereby. For example, if the active oxygen continues to be excessive in the skin due to ultraviolet rays or radiation,
It reacts with the unsaturated fatty acids of the phospholipids of biological membranes to generate lipid peroxides, which may cause arteriosclerosis, carcinogenesis, membrane destruction, protein degeneration, skin inflammation, and edema. Is done. Furthermore, from a cosmetic point of view as a disease due to excess active oxygen, from the viewpoint of herpes dermatitis, x-ray dermatitis, burns, trauma, sunshine dermatitis, contact dermatitis, eczema, atopic dermatitis, etc. Instead, it induces an increase in glycosaminoglycans, cross-linking and reduction of collagen fibers, denaturation of elastic fibers, etc., causing the skin to lose its elasticity, causing external changes such as wrinkles and loosening. It is known that the phenomenon is promoted.

[0005] In order to prevent or ameliorate the above-mentioned diseases, substances such as superoxide dismutase (SOD), catalase, glutathione peroxidase, In addition, tocopherol (vitamin E), oryzanol, plant extracts (hamamelis, melissa, emisoso, birch, sage, rosemary, age, basil, ginkgo, psycho, peonies, hange, cahig, tissou, ogong, carrot, licorice, ginger) Its usefulness has been pointed out.

[0006] Conventionally, in order to prevent skin and hair from drying out, cosmetics and other external preparations include glycerin, propylene glycol, 1,3-butylene glycol, other polyhydric alcohols, oil and fat components, amino acids, proteins and polyhydric alcohols. Sugars,
Mucopolysaccharides and the like have been used.

[0007] The purpose of these methods is to make a film by applying it to the skin or hair, to prevent the evaporation of water, and to make it close to the natural moisturizing factor (NMF), a stratum corneum component called NMF (Natural Moisturizing Factar). It was.

[0008]

However, the active oxygen-scavenging substances mentioned above are poor in stability and solubility in a formulation system, and give off odor and color due to sedimentation and decomposition, and also have an effect at a biological level. Is not enough,
It was not satisfactory in actual use, for example, there were safety problems such as skin irritation.

Furthermore, conventional moisturizing components have not been satisfactory in terms of feel, sustained moisturizing effect, safety, and physicochemical stability. In particular, the moisturizing effect of the conventional components is temporary, and cannot be said to be a sufficient topical composition for maintaining and regenerating healthy skin or hair, such as prevention or improvement of rough skin and split ends.

[0010]

Means for Solving the Problems The inventors of the present invention have conducted intensive studies in view of these circumstances, and as a result, an extract obtained from an orchid plant has excellent usability and effective active oxygen scavenging (S).
(OD-like) action and lipid peroxide production inhibitory action, and succeeded in finding usefulness as an antioxidant, and also confirmed useful as a humectant. In addition to reducing spots and wrinkles on the skin, improving rough and dry skin,
Further, the present invention has been completed by providing a highly safe cosmetic composition capable of giving gloss and tension to the skin.

[0011] The present invention provides an antioxidant characterized by containing one or more plant extracts selected from orchids.
The present invention relates to a humectant or a cosmetic composition containing the same.

[0012] The orchid plant may be selected from the group consisting of a silane, a genus, a rhinoceros, a genus of genus, a lantern, a genus of genus, a genus of genus, a genus of a genus, a genus of radish, a genus of Oninoyara, a genus of Sakanelan, a genus of Orchis, and a genus of vanilla. The present invention relates to an antioxidant, a humectant, or a cosmetic composition containing these, which is one or more selected from the group.

[0013]

DETAILED DESCRIPTION OF THE INVENTION The orchid plants used in the present invention are as follows.
Leaves, branches, stems, bark, rhizomes, root bark, roots, root nodules or whole plants can be used, but those available as crude drugs may also be used. In addition, these hybrids and varieties can also be used.

The orchids used in the present invention include (1) plants of the genus Silane, for example, silane (Bletilla striata)
(Thunb.) Reichb.f.) (Herbal medicine name: white kyu). (2) Kinlan plants, for example, Ginran (Cephalanther)
a erecta Lindl.), Yushrun (C. erecta var.s)
ubaphylla), Kinran (C. falcata (Thunb.) Bl.), Sasabaginran (C. longibracteata Bl.), C. longifol
ia (L.) Fritsch, Kugenumaran (C. shizuoi) and the like. (3) Rhinoceros plants, for example, rhinoceros (Crem
astra appendiculata (D.Don) Makino = C. variabilis (B
l.) Nakai), Tokenran (C. unguiculata (Finet) Fine)
t) etc. (4) Plants belonging to the genus Sunran, for example, Hetkaran (Cymbidiu)
m dayanum Reichb.f.var.austro-japonicum Tuyama),
C. eburneum Lindl., Surgaran (Oran) (C.ensifoli
um (L.) Sw.), Shunlan (C. goeringii (Reichb.f.) Re
ichb.f.), C.insigne Rolfe, C. kanran Ma
kino), C. lowianum Reichb.f., Harkanran (C. × n
ishiuchiana Makino), kinryohen (C. pumilum R)
olfe), Hosairan (C. sinense (Andr.) Willd.), etc.
In addition, what is generally called cymbidium can be used. (5) Plants of the genus Swanbird, for example, Swanbird (Dactylorhiza aristata (Fisch.) Soo = Orchis aristat
a Fisch.), D. incarnata (L.) Soo, etc. (6) Plants of the genus Gypsophila, for example, Dendrobium aggregatum
Roxb., D. chrysanthum Wall.ex Lindl., D. fimbriat
um Hook.var.oculatum Hook., D. kingianumLindl., D. linawianum Rchb.f., D. loddiges
ii Rolfe, Sekkoku (D. moniliforme (L.) Sw. = D. moni
le (Thumb.) Kraenzl.), Koukisekoku (Obanasekko) (D. nobile Lindl.), Okinawan Koseki (D. ok
inawenseHatusima et Ida), D. offici
nale K. Kimura et Migo, D. phal
aenopsis Fitzg.), Taiminsekkoku (D. speciosum)
Smith.), D. tetragonum A. Cun
n.), D. tosaense Makino, etc., and those commonly called dendrobium can also be used. (7) Plants of the genus Perilla, for example, perilla (Epipactis th
unbergii A.Gray), Ezo lily of the valley (E. papillosa Fr.e)
t Sav.), Aoszlan (E. helleborine (L.) Crantz v
ar. papillosa (Franch et Sav.) Hashimoto = E. papillo
sa Franch etSav.), Hamakakiran (E. helleborine v)
ar.sayekiana) and the like. (8) Plants of the genus Rhododendron, for example, Rhododendron (Galeola)
septentrionalis), G. altissima (B
l.) Reichb.f.) etc. (9) Oninoyagara plants, for example,
rodia elata Bl.) (herbal medicine name: Tenma), Aotenma (G. el.
ata forma viridis Makino). (10) Sakanelan plants, for example, Sakanelan (Ezosakanelan) (Neottia nidus-avis (L.) LCRich.var.manshu
rica Kom. = N. papilligera Schltr.), Tsukushikaneran (N. kiusiana), Himemyouran (N. asiatica)
etc. (11) Plants of the genus Orchis, for example, Orchis chimney (Orchis chi
dori Makino = Ponerorchis chidori (Makino) Ohwi), Onoelan (O. fauriei = Chondradenia fouriei), Ochouran (O. graminifolia (Reichb.f.) Tanget Wang = P
onerorchis graminifolia Reichb.f.), Grey-headed Butterfly (O. joo-iokiana Makino = Ponerorchis joo-iokiana)
(Makino) F. Maekawa), O. latifolia L., O. mascula,
O. morio, O. purpurea and the like. (12) Vanilla plants such as Vanilla abundiflora and vanilla (V. fragrans (Salisb.) Ames. = V. planifolia And
r. = V. mexicana Mill. = V. aromatica Sw. = Myrobroma
fragrans Salisb.), Western Vanilla (V. pompona)
Schiede = V. Grandiflora Lindl.), V. tahitensis and the like.

The orchid extract used in the present invention includes:
Various parts of the plant are squeezed after being crushed or crushed. Alternatively, it is extracted with a solvent as it is or after pulverization.

Examples of the extraction solvent include water, alcohols (eg, lower alcohols such as methanol, anhydrous ethanol and ethanol, or polyhydric alcohols such as propylene glycol, 1,3-butylene glycol and glycerin), and ketones such as acetone. , Ethyl ether, dioxane, acetonitrile, esters such as ethyl acetate, organic solvents such as xylene, benzene, chloroform, etc. can be used alone or in any combination of two or more. Can also be used in a state where.

These extracts can be arbitrarily prepared by drying, concentrating, diluting, or mixing with other components, depending on the dosage form and form to be applied.

The extraction is usually carried out under normal pressure, and may be heated to increase the efficiency. After the extraction, the solution is purified by filtration and / or using a column such as an ion exchange resin to obtain a solution, paste, gel, or powder. In many cases, the extract can be used as it is, but if necessary, it is possible to carry out further purification treatments such as deodorization and decolorization as long as the effects of the present invention are not affected. In addition, as a purification treatment means such as deodorization and decolorization, an activated carbon column or the like can be used.

One or more plant extracts selected from the orchids of the present invention can be used as an antioxidant, a humectant or as a raw material to be incorporated into a cosmetic composition. The content thereof varies somewhat depending on the type of the applied dosage form, the method of use, and the expected degree of action, but is usually 0.001% by weight or more (hereinafter expressed as%) as solid content, and preferably about 0.01 to 50%.

The antioxidant, humectant or cosmetic composition according to the present invention may contain, in addition to the above-mentioned essential extract, any of the following components and additives within a range that does not impair the effects of the present invention. Can be selected and used in combination.

(1) Various fats and oils Avocado oil, almond oil, fennel oil, perilla oil,
Olive oil, orange oil, orange luffer oil, sesame oil, cocoa butter, chamomile oil, carrot oil, cucumber oil, tallow fatty acid, kukui nut oil, safflower oil, shea butter, liquid shea fat, soybean oil, camellia oil, corn oil, rapeseed Oil, persic oil, castor oil, cottonseed oil, peanut oil, turtle oil, mink oil, egg yolk oil, palm oil, palm kernel oil, mocro, coconut oil, tallow, lard, or hydrogenated products of these oils (hardened oil, etc.) )etc.

(2) waxes Beeswax, carnauba wax, whale wax, lanolin, liquid lanolin, reduced lanolin, hard lanolin, candelilla wax,
Montan wax, shellac wax, rice wax, squalene, squalane, pristane, etc.

(3) Mineral oil Liquid paraffin, vaseline, paraffin, ozokelide, ceresin, microcrystalline wax and the like.

(4) Fatty acids Natural fatty acids such as lauric acid, myristic acid, palmitic acid, stearic acid, behenic acid, oleic acid, 12-hydroxystearic acid, undecylenic acid, tall oil, lanolin fatty acid, isononanoic acid, caproic acid And synthetic fatty acids such as 2-ethylbutanoic acid, isopentanoic acid, 2-methylpentanoic acid, 2-ethylhexanoic acid and isopentanoic acid.

(5) Alcohols Ethanol, isopiranol, lauryl alcohol,
Natural alcohols such as cetanol, stearyl alcohol, oleyl alcohol, lanolin alcohol, cholesterol, phytosterol, phenoxyethanol,
2-hexyldecanol, isostearyl alcohol, 2-
Synthetic alcohols such as octyldodecanol.

(6) Polyhydric alcohols Ethylene oxide, ethylene glycol, diethylene glycol, triethylene glycol, ethylene glycol monoethyl ether, ethylene glycol monobutyl ether, diethylene glycol monomethyl ether, diethylene glycol monoethyl ether, polyethylene glycol, propylene oxide, propylene glycol , Polypropylene glycol, 1,3-butylene glycol, glycerin, pentaerythritol, sorbitol, mannitol and the like.

(7) Esters: Isopropyl myristate, isopropyl palmitate, butyl stearate, hexyl laurate, myristyl myristate, oleyl oleate, decyl oleate, octyl dodecyl myristate, hexyl decyl dimethyloctanoate, cetyl lactate, Myristyl lactate, diethyl phthalate, dibutyl phthalate, lanolin acetate, ethylene glycol monostearate, propylene glycol monostearate, propylene glycol dioleate and the like.

(8) Metal soaps Aluminum stearate, magnesium stearate, zinc stearate, calcium stearate, zinc palmitate, magnesium myristate, zinc laurate, zinc undecylenate and the like.

(9) Gum, sugar or water-soluble polymer compound Arabic gum, benzoin gum, dammar gum, guaiac oil, Irish moss, karaya gum, tragacanth gum,
Carob gum, quinseed, agar, casein, lactose,
Fructose, sucrose or an ester thereof, trehalose or a derivative thereof, dextrin, gelatin, pectin, starch, carrageenan, carboxymethyl chitin or chitosan, hydroxyalkyl (C2-C4) to which an alkylene (C2-C4) oxide such as ethylene oxide is added. )
Chitin or chitosan, low molecular weight chitin or chitosan, chitosan salt, sulfated chitin or chitosan, phosphorylated chitin or chitosan, alginic acid or its salt, hyaluronic acid or its salt, chondroitin sulfate or its salt, heparin, ethyl cellulose, methyl cellulose, carboxymethyl cellulose , Carboxyethylcellulose, sodium carboxyethylcellulose, hydroxyethylcellulose, hydroxypropylcellulose, nitrocellulose, crystalline cellulose, polyvinyl alcohol, polyvinyl methyl ether, polyvinylpyrrolidone, polyvinyl methacrylate, polyacrylate, polyalkylene oxide such as polyethylene oxide and polypropylene oxide Or its cross-linked polymer, carboxyvinyl polymer, polyethylene N'imin like.

(10) Surfactant Anionic surfactant (alkyl carboxylate, alkyl sulfonate, alkyl sulfate, alkyl phosphate), cationic surfactant (alkyl amine salt, alkyl quaternary ammonium salt) ), Amphoteric surfactant:
Carboxylic acid type amphoteric surfactant (amino type, betaine type), sulfate ester type amphoteric surfactant, sulfonic acid type amphoteric surfactant, phosphate ester type amphoteric surfactant, nonionic surfactant (ether type nonionic) Surfactants, ether ester nonionic surfactants, ester nonionic surfactants, block polymer nonionic surfactants, nitrogen-containing nonionic surfactants, and other surfactants (natural surfactants) , Derivatives of protein hydrolysates,
Polymer surfactants, surfactants containing titanium and silicon,
Fluorocarbon surfactants).

(11) Various vitamins Vitamin A group: retinol, retinal (vitamin A
1), dehydroretinal (vitamin A2), carotene, lycopene (provitamin A), vitamin B group: thiamine hydrochloride, thiamine sulfate (vitamin B1), riboflavin (vitamin B2), pyridoxine (vitamin B)
6), cyanocobalamin (vitamin B12), folic acids,
Nicotinic acids, pantothenic acids, biotins, choline,
Inositols, vitamin C group: vitamin C acid or a derivative thereof, vitamin D group: ergocalciferol (vitamin D2), cholecalciferol (vitamin D3),
Dihydrotaxelol, vitamin E group: vitamin E or its derivatives, ubiquinones, vitamin K group: phytonadione (vitamin K1), menaquinone (vitamin K
2), menadione (vitamin K3), menadiol (vitamin K4), other essential fatty acids (vitamin F), carnitine, ferulic acid, γ-oryzanol, orotic acid, vitamin Ps (rutin, eriocitrin, hesperidin), vitamin U etc.

(12) Various amino acids Valine, leucine, isoleucine, threonine, methionine, phenylalanine, tryptophan, lysine, glycine, alanine, asparagine, glutamine, serine, cysteine, cystine, tyrosine, proline, hydroxyproline, aspartic acid, glutamic acid , Hydroxylysine, arginine, ornithine, histidine, etc., and their sulfates, phosphates, nitrates, citrates,
Or amino acid derivatives such as pyrrolidone carboxylic acid.

(13) Various additives derived from plant or animal raw materials These are processed in a conventional manner according to the type and form of the product to be added (for example, grinding, milling, washing, hydrolysis, Fermentation, purification, compression, extraction, fractionation, filtration, drying, powdering, granulation, dissolution, sterilization, pH adjustment, deodorization, decolorization, etc. You can choose to serve.

[0034] The solvent used for the extraction may be selected in consideration of the purpose and type of the product to be provided, and the processing to be performed later. ,Propylene glycol,
It is preferable to use one or a mixture of two or more selected from 1,3-butylene glycol). However, when the content of the organic solvent is not preferable depending on the application,
Only water may be used, or ethanol which is easily removed after extraction may be used, and may be used alone or in any mixed solution with water, or may be extracted and extracted.

In addition, additives derived from plant or animal raw materials are
When applied to systemic or topical external preparations and cosmetics, including protection of skin and hair, moisturizing, improvement of feel and texture,
Giving flexibility, relieving irritation, relieving stress by fragrance, activating cells (preventing cell aging), suppressing inflammation, improving skin and hair quality, preventing and improving rough skin, hair growth, hair growth, hair loss prevention, gloss Application, cleaning effect, relief of fatigue, promotion of blood flow,
In addition to cosmetic effects such as warm bath effect, fragrance, deodorant, thickening,
Antiseptic and buffering effects can also be expected.

Specific plants (crude drugs) as raw materials include
For example, almonds (Hentomo), eye (Aiba), Blue Kazura
(Seifu Fuji), Aoki (Aoki), Aokiri or Kenasia Ogiri
(Otogi), Aotsujirafuji (Kibo), Acacia, Akasho (Akasho), Akasuri `` fruit '', Red clover, Red grape, Akaminoki (Logwood), Akamegawiwa (Red bud), Akaminokane or Akanekane or Akane
(Akane grass root), Acacia elegans or Jiou (Jihuang), Agi (Awei), Aki larch, Akinire (Royu skin), Aguai
Guacu, Aguahe (Omitengu palm), Akebi (Kidori), Asa (John Asahi), Maruba Asagao or Asagao (Toshibushi), Hydrangea (Hydrangea), Ashitaba (Tomorrow's leaf), Azuki (Red adzuki bean), Asunaro, Acerola, Asenyak ( Asenyaku), Achilla (Shokuyoukanna), Anise, Abiu, Abiulana, Brassica, Abemaki `` Fruit '', Avocado, Ama, Amacha (sweet tea), Amachaworu, Amadokoro (Tamatake), Amana (Kojingi), Amaranth (Hiyuyu) , Balsam pear, Papilio xanthus, Senninkoku, Sugimorigeito, Hosoaoigaito, Aougeto, Haribiyu, Amaranthus hippochondriax), Amigasa lily or Bimo (shellfish),
Aristolomelia (Yurizisen), Arcana (Alcanna), Algarrobo (Cabbage), Altea, Arnica, Alpinia or Katsumadai (Souduq), Aloe (Length), Aloe vera, Angelica, Apricot or Hong apricot (Anjin), Ansokkou (Azusa), Yellow sapote , Ikakozorina (ground bile head), Epimedium or Epimedium
(Inyokaku), Igusa (Wicked grass), Knotweed (Tiger root),
Strawberry (first place), strawberry, fig (Fig.
Leaf)), Ichihatsu (first time), Ichibi (Fruit Aoi), Ichiyakusou (one medicinal herb), Ginkgo (Ginkgo `` seed, leaf ''), Itohimemegi (Enshi), Carob, Inu-zuna (Telelexi), Inubeyu (Sorainubiyu), Rice `` seed, seed coat '', Inondo `` seed '', Ibuki-kusou-so, nettle, ylang-ylang, iwa-tobacco (iwatsuchi-chi), iwahiba or iwamatsu (makikashiwa), oolong tea, wikyo (fenka), wheat (tibusanoki), ukiyagara (miyoko) ), Uguisukagura "fruit",
Himeuikyo, turmeric (Utsukin), duckweed (buoying), Usubasaishin or Keirinsaishin or Shousaisaishin (spicy), Usvenia oi, Usvenitai oi, Utsubogusa (summer dry grass), Udo or Shishiudo (Qangji, Independent, Tang Independent) ), Unya de Gato (Unkaria, Cat's claw), Uba tea, Plum (Ume `` seed, pulp ''), Vladimir, Owaurushi (Kusaco peach), Unshu mandarin (Chen skin), Unboku, Estragon, Ezocogi (Ezo five), Echinashi
(Hoshibamurasakibarengiku), Enishida, Enokitake
(Enoki mushroom), Ebisugusa or Cassia tora (Kyoko), El Campre, Elderberry `` fruit '', Elemi, Eryngii or Pre-Lotus Eringe, Endu (Gossip, Sophora rice), Ougi or Kibana-ohgi (Ohioki), Ousei (Naruko Yuri, Kagikuruma Banaruko Yuri), Ohisasanoyuki or Sasanoyuki, Ouren (Yellow), Ogata Hawken, Ookarasuri (Karokon), Ooguruma (Public engineering incense), Ooturafuji (anti-self), Oobako (forehead child, car front grass), Oobaa (Keju Leak, Hakuto Okina), Toucan (Haruko), Toucan cactus, Oobanokera or Okera (white juku), Oobansarusubari (Banaba), Oobayashibashi "fruit", Ooishigusa (cereal grass), Oumiacatetsu, Omihacateshi or Omihasabi Hawthorn (Yamako), barley (barley), oka, okazeri (snake bed), okra `` fruit ``, Oguruma (turning over), Okurichurigotai (Yusyu sashimi, indigo stalk), Panax ginseng or Ginseng (carrot), Hypericum or Scutellaria perforatum or St. John's wort (brother's cut grass), Odorikosou (interrupted), Onamimomi (blue ear) Offspring), Onigurimi, Onidokoro or Tokoro or Nagadokoro (Hikari),
Oninoyagara (Tenma), Oniyuri or Sasayuri or Hakataliyuri (Yuri), Ononis, Halibut (Hihayu), Ominaeshi
(Losing sauce), Oyuco, Dutch mustard (Watercress), Dutch jelly, Dutch biyu, Dutch honeywort, olives "fruits, seeds, leaves", oregano, orange "fruits, peel",
Kaikei Soji (ripe ground yellow), cacao `` fruits, peels, seeds '', oysters (persimmon `` leaves ''), kagikazura (fishing hooks), oysters or kantosou (rensensou), gaku hydrangea, cassia, casino "Fruit"), gajutsu (shajutsu), Kashiwa
(Sakura tree, Sakhalin), cascallilla, cascara sagrada, gypsophila, kasenso, kanikusa (kinsato), kaniwa, carnation, kanokoso (yoshikusa root), hippopotamus, birch or weeping birch (white birch), gerbera, pumpkin, capoknoki `` seed ``, Kahokoku-sansho (shopper), Gama (bamboo), Chamomile or Roman chamomile, Kamiyadee (weed), Kamkamu (Kamokamo), Color, Karaku-Sakeman, Karasuuri or Shinakarasuri (Our melon), Karasubishak (Half-summer), Okaramugi , Guarana `` seed '', Karahoo (Thick), Karaya, Galyu, Karin (Gourd melon), Garcinia, Kawamidori, Kawara Psycho (Seirinsai, Hakubaku), Kawajisha, Kawaratake,
Kawaranadeshiko (stone bamboo) or Ezokawaranadeshiko (Quat,
Quinko), Chinese carrot (Aogo), Japanese sagebrush (Inchinko), Kansui (Sweet), Licorice (Licenzo), Kantarasa, Candelilla, Kanto, Canna, Rubus strawberry (Ezo strawberry, Dutch strawberry, Shrimp strawberry, Pear strawberry, Maple strawberry, (European strawberry), Kiwi (fruit, leaf), Kikarasuuri (Ururone), Kikyo (Kikyo, Kikyo root), Chrysanthemum (Chrysanthemum, Simakangiku, Datura), Kikutani daisy, Catalpa (Azumitsu), Japanese daisies (Yotei) , Pheasant (Kikomi), kizuta, kidachi aloe, lucky mint, kina, linden (shincona, linden), quinoa (quinoa), chinen (yellow), gymnema sylvestre,
Kimmenkaku, cabbage, cabbage `` immature fruit '', caraway, cucumber, gyoryu (Nishikawayanagi, Ichiyanagi), Kiraja saponaria, Kiraya, Kiranso (gold pea grass), kumquat `` fruit '', ginseng, kimbusen, betel, kinmizukiki ( Senpaku herb), Guapeva vermelilla, Guava `` fruit '', guayule, Quercus infectria (gallicate), cucuin nuts, wolfberry (Gugi, gugiko, gugi leaf, skeletal bark), Kusagi-kazura (Tenmen winter), Kudzu (Kuzukane) ,
Camphor tree, gooseberry `` fruit '', ginseng, yellowtail, gardenia, gardenia, kunugi, kupuas, kubeba, kumazasa, black pine, serrata, cranberry `` Fruit '', chestnut `` seed, fruit, astringent skin '', curcrigo lachifolia `` fruit '', grapefruit `` fruit / leaf '', buckthorn, black squirrel (rescue rescue), turtle bamboo grass or kurobana hinoki okoshi or hiki okoshi (extended life grass), clove (cinch, choko) ), Gunbaizuna (Sekimei, Sekimeishi),
Kaigai (Thorndust, Ikutakeho), Celosia (Rooster, Chicken),
Gekkavidin, bay (laurel), Kenashisarutibara (Tsuchukuryo, Yamakiko), gentian, gennoshoko
(Old tongue grass), Kemponashi (Kigushi), Koukisekikoku, Kishumitsukan (Koji, Tachibana, Oveni mikan, Fukuromikan, Sagamikouji, Ponkan, Santara (Tachibana bark)), Koushinbara (Monthly flower), Kosuihakka, Kozo `` Fruit '' , Kocha (tea), Kouhone (river bone), Kohon
(Straw book, Kara straw book), Koryang, Kouryokyo (Kora Kyo), Cilantro `` fruit '', Kourouen (Kohren), Koganebana (yellow gon), Cowberry (Koshibachi), Coco palm `` Fruit '',
Goshuyu (goshuyu), Goshoichigo (covered bonko), pepper
(Pepper), cosmos, copaiba balsam, coffee `` seed, leaves '', kobushi or magnolia (hot spring), burdock (burdock,
Burdock), kobotdur, sesame (sesame), sesame seeds (gensin), garnish (gomiko), sanekazura or binankazura or matsubusa, wheat (wheat), rice or rice bran "red bran, white bran", rice oil, cola acuminata " Seeds ", cola
Vera “seed”, colony lya, fenugreek “fruit”, colombo, conzlango, kelp, konjac, comfrey
(Final barn grass), sisal (sisal asa), saxima button or syna button or cinnamon
Sakura (Ooshimazakura, Yamazakura, Oyamazakura, Edhigashi, Mamezakura, Miyamazakura, Someiyoshino, Takanezakura, Kasumizakura, Kohigan, Satozakura, Kanzakura `` Leaf, flower, fruit, bark (cherry bark) ''), cherry, pomegranate, sasa, sasanqua, Sadomodaka (Sawaka), sweet potato, sugarcane, sugar beet, jujube jujube (acid jujube), saffron (banana flower, west safflower), sapodilla, sapotea marillo, pomelo `` fruit '', sabonso,
Salmon berry `` fruit '', sardine ginger (masa), salamanthus (sand sashimi), salvia (sage), sawagikyo (yamachona), sawagurumi (yamawomo), sankaku cactus,
Sangre degrad (croton), Sansuiyousou, Sansin ginseng (seven carrots), Sanshuyu (sanshuyu), sansho (sanshoyu), sanzukon (Yamazone), shea (carite), cyanoki `` fruit '', shiitake ( Shiitake mushrooms), Shion (Shien), Dikitaris, Sikunshi (Kimiko), Perilla or Aodiso or Chirimenjiso or Catamejiso (Shiso leaf, Shiso), Rosewood,
Linden, linden tree, cinnamonium (forsythia), shimeji (hinshimeji, shakashimeji, hatakeshimeji, oshiraishimeji, bunashimeji, honjimesi, shirotamogitake), shimokren (spicy), shimotsusou, potato,
Peonies (shakuyaku), shajin (shasan), jasmine (matsurika), janohige (wheat gate winter), gypsophila,
Sukushamitsu (sand flakes, shrunk sand), juzdama, palm `` fruit '', ginger (ginger), ginger hydrangea (Tsuneyama), shobu (iris, iris root), shojiku `` fruit '', shirakashi `` seed '', shirogoshi `` seed '''', White clover (clover), white adzuki (chicken bone), white iris (small iris), white banana (flower), white nana (flower), white nananten (minamitenmi), cinchona sacsylbra, ginkouge (mizuka, mikaka, shencho), cinnamon, cinnamom・ Cassia (cinnamon bark), watermelon (watermelon), honeysuckle (gold and silver flowers, Shinobi winter),
Sorrel (acid model), swimberry `` fruit '', star apple, stevia, strawberry `` fruit '', suzu psycho (Xu Chang Lord), horsetail (Qing Ting), purslane (horse dent, horse dent), plum `` fruit '', pear Japanese red pine cones, larch, larch, walnuts, hawthorn, eucalypt, dandelion,
Horse chestnut (Marronnier), pear `` fruit '',
Snowflower, elderflower,
Atlantic shrew (juniper, Juniper), Achillea millefolium (milfoil), A. rose, A. antelope, A. aegypti, A. aegypti or A. aegypti, A. horseradish, Sekisho (Iris), Sekoku (Ishiboshi), Sedron, A. , Hirohasenega, senega, seri, celery, senkyu
(River Kyu), Senshinren (Senshinren), Sendan, Sennin Cactus, Senna `` Fruits, Leaves '', Senninsou (Large Tate), Senburi (Drugs), Senboku, Soka (Grass), Zougechu, Soshinroubai, Buckwheat `` Seeds '', Soybean Potato, Rhubarb (Daio), Radish, Soybean, Daidai (Orange, Kikomi), Takasago Rurigo Thai (Southeast Aizashi), Takasaburo (Dried Lotus), Takatodai (Daigo), Takawarabi ,
Dark sweet cherry "fruit", hollyhock, hollyhock (thyme, Hyoka), hollyhock (hika), hollyhock, tamarind "seed", onion, tamashiba
(Shinyi), Tara tree `` fruit, leaf, root bark '', Tarayou (large leaf winter blue, one leaf tea, bitter tea, bitter tea), dahlia (tenjikubotan), tarui, tanshiuchiwa, tanjin (dansan), dandelion (gakkoei) Or white dandelion or moko dandelion, dammar, cherry "fruit", cypress "fruit, root,
Buds '', carrots (bamboo carrots), chicory, chancapiedra (golden ginseng), ginseng
(Ohta), Korean lance (Wuyi), Artemisia (Aiba), Choreimaitake (Irei), Japanese cricket, Tsukimisou, Tsukuritake (mushroom), Camellia, Camellia,
Tsumekusa (lacquer lacustrine), twigweed (duckweed), vine adzuki (red azuki bean), tsuldokudami (what crow), tsuruna (banyou), tsujin carrot (four-leaf ginseng), tsuwabuki, deiko, teuchigurumi, duberry `` fruit '', tulip, chocolate Nostay, Tengusa, Tencha (tencha), Tendai yak (crowd), Pepper (winter gourd), Toukagizura, Pepper (bancho), Touki (Toki), Tokinsenka (Marigold), Tounabena (River cut), Corn or corn hair (nanban hair),
Ligustrum Mochi (Female Sadako), Gourd or Datura (Ryubile), Tokusa (Wooden), Dokudami (Jyuku), Tokon (root), Toshishi or Mamedaoshi or Guinea pond, Eucommia (Tonaka `` bark, leaves, roots '') , Ash (qin peel), tomato, tragacanth, triacanthus `` seed '', eustoma, tormentilla, dronoki, troloioi, tongue bean, Niseria berry `` fruit '', potato or yamanoimo (herbal medicine), nagaikadada (butcher bloom), naginata koju, Japanese rape, oilseed rape, oilseed rape or mandarin
(Swords), Natsumikan, Jujube (daijutsu), Naniwaibara (Kinzakurako), Navena (Continuous), Nameko, Narukoyuri (Yoshisei), Peanut (peanut), Nanten (Minami Tenmi), Nanbankarashi (ramie), odor Violets, bitter oysters (bitter wood), sagebrush
(Bitter mushroom), nutmeg, kei or nikkei or Ceylon nikkei or yab nikkei (cinnamon bark) or keiseki (keishi), leek
(Niriko), elderberry (bone-bearing tree `` fruit, flower, stem, leaf ''), garlic (garlic), nurde (five times), leek, nemoki or neb or nebi or nemuriki or digokbana (health), thistle (Oji) , Noibara (real fruit), Nozenkazura (Ryoshohana),
Lacewing, Yarrow, Sawdust (Maehu), Nobara, Nomomo, Pineapple `` Fruit '', Hibiscus (Bussouge, Furinbussouge, Roselle), Hirindou,
Hauchiwa, Pau Doce, Hakayamauraboshi (bone crushing), Hakuka Yumato, Hakusen (ringworm skin), Hakuruberry `` fruit '', Hakobe (frequent radish), Hashibami (Haruko), Hashidokoro
(Roth root), basil, lotus (lotus, lotus, lotus), parsley
(Netherland jelly), naked mussel, batata, bee or medake (bamboo boiled), patchouli, mint (lightly loaded, lightly loaded leaves), barley (yokuinin), hanasuge (chimbo), banana, hana mint, hanabishi (situri, shisuturi), vanilla bins , Papaya, japonicus (rat koji), pahalobobo, hub "whole plant, stem, leaf", paprika, hamago or honeysuckle
(Vine vine), hamasuge (katsuki), hamabishi (shikoriko), hamanas (maikai flower), hamabafu (beach storm), hamamelis, palm, rose (rose), balata, balata rubber tree,
Agaric (Agaricus, Agaricus agaricus, Uskimorinocasa), Haran, Pariurus (Pleurotus japonicus), Parietaria, Balsamina (Tsurureishi, Nigari), Harunire (Yellow, Yuzhi bark, Yuba), Barbasco, Harlindou, Handaikai ), Breadfruit, giant gourd (radish), lizard ginseng (party), pecan nuts, giganbana (garland, vines), higurumadaria, higotai, ishi (hishomi), pistachio, beet, hitsuba (stone reed), Aedes aegypti, daisies (daisy), hinata nokozuchi (cow knees), hinoki, hiba, castor, sunflower,
Bell pepper, Himeuzu (Tamaoi), Himegama (Kaba), Himematsutake (Kawariharatake, Hiromatsutake), Pimenta `` Fruit '', Juniper, Biancucuum, Hyacinth `` Fruit '', Belowudo Oi, Hiroha Okinagusa (Hakuto Okina), Loquat `` Fruit,
Leaves, stems ”, betel nut (large clothing skin, betel nut), puer tea (
Tea), spruce buds (southern rattan), butterflies, coltsfoot (populations of winter flowers, copulations of winter leaves), fujibakama (orchids), fujimame (flat beans),
Fujimodoki (choujizakura, shikahana), grapes `` fruit, peel, seeds, leaves '', beech, fuyumushinatsukutake (Cordyceps sinensis), Brazilian liquorice, Brazilian carrots, black currant `` fruits '', blackberries, blanin,
Plum `` fruit '', flucellaria, blueberry (Acacia catechu), prune, floral blanka, blond psyllium, bundou (green bean), hazelnut, loofah, safflower (safflower), henneken, belladonna, berry `` fruit '', Percea, Perbianberg, Pereskia
Grandifolia, Bensui beetle or duckweed (Keiten), Boysenberry `` fruit '', Broomweed or Elderweed or Nendow or Hawakigi kokia (dermis), Baldwink (Hosen, acute child, osteophyte), Potteria sapota, potteria Lucuma, spinach, boufu (windbreak), spinach, physalis (Torone), honoki (Japanese magnolia, park), bokeh
(Gourd melon), Hosoba aburagiku (bitter gourd), Hosoba oguruma,
Hosovanaokera (Aojutsu), Hosobanokirinsou (Kageten 37), Hosobabarengiku, Bodaiju (Bodaiju), Button
(Peony `` flowers, leaves, stems, bark ''), buttonpies (peony bark), hops, jojoba, borage (ruriichisha), bordeaux, white berries `` fruits '', hon-onik (meat porcelain, daigei), hon-sekko (iron Peeling stones, sparrow mountain stones), myzuruten nansha (Tennan star), maitake (maitake), ephedra (mao), maca, macadamia nuts, margaret (mokushungiku), macri (seaman grass), maguwa (mulberry white bark) `` Bark, leaves ''), Magnolia splengeri, Masaranpouba, Masaranzuba do Ceara, Masheira de Boi, Masahua (Tamanouzenhallen, Cucumber kinrenka), Matatabi (Kiten Tate), Matsukasa, pine `` leaves, bark, Roots, Matta Oryo, Matsuhodo (Bukuryo), Matico (Cordoncillo), Mayorum (Hanamint), Malvanojadine (Bitterfruit), Mulberry "Fruit", Quince, Murray (Below mou watermelon), mango, mangosteen, mansagna (andesukamitsure), mansugurumi, mandarin `` fruit '',
Mannentake (Lingzhi), Pheasant (Kikomi `` fruits ''), Mishimasaiko (Saiko), Mizuobako or Mizuasagao (Ryugoshi),
Mizokukushi (Hanbe Lotus), Misohagi (Chisatsuna), Mizunyanagi or Shiroyanagi (Henryoku), Mitsugashiwa, Mitsuba, Midorisapote, Midorihakka, Mimosa, Myoga, Miracle Fruit `` Fruit '', Myrrh, Milobalan, Wheatwaragiku, Mukuge (Mokuge) , Mukunoki, Mukuroji (extended skin), Munya, purple (purple root), purple or purple purple
(Purple beads), purple corn, purple purple (Kunming chicken blood wisteria), megakanza opuntica, red seaweed (mother grass), red seaweed, melaleuca, melissa, melilot,
Melon `` fruit '', sagebrush, moso bamboo, moku giraffe, moje (koshoboku), ilex, mokko (wood incense), maple blossom, peach (peach `` leaves, seeds, flowers, fruits ''), bean sprouts, morello cherry , Moroheiya
(Burlap), yakawamurasakiimo, yakuchi (masuti), cornflower mackerel (cornflower), cornflower mint, yacon, yashabushi (arrow car) or himeyashabushi or giant yashabushi `` fruit, peel, kaho '', yachiyanagi, yatsude (octagonal metal) , Mistletoe (willow parasitism), willow (river willow, twill willow, weeping willow, red willow, pussy willow, dog puppy willow, kinuyanagi, kolyanagi, unryuyanagi, yamayanagi, palm, yamayanagi, obanyanagi,
(European willow, fox, willow tree)
Japanese tobacco (Tsurusui, Tenmei), Japanese pokeweed (land), Japanese alder (Yamaharu), Japanese peach (Yumemei), Japanese sagebrush, Eucalyptus, Yukinoshita (Tiger ear grass), Yucca or flevifolia, Yuzu `` fruit '', lily, Artemisia, mugwort (Aiba),
Rigan (Raimaru), lime `` fruit '', rye, lacanca `` fruit '', raspberry `` leaves, berries '', ratania (clameria), raccoon or shallot (scallop), lavender, longan (longan meat), agave (Aonouragetsu, fukurin) Agave), Ryokucha (green tea), Apple `` Fruits, seeds, leaves, roots '', Gentian, Rubus or Suabisimus (Tenryu), Ruritama thistle (Urajirohigotai, Xinjiang indigo sashimi), Reishi (Lichi, Lichi nucleus), Lettuce (Chisha), Red currant `` Fruit '', Red pitaya, Lemon `` Fruit '', Lemongrass, Forsythia or Chinese forsythia (forsythia), Astragalus, Lumbai (wax plum), Waxy palm, Lokon (Yoshi, Azuki), Loganberry `` Fruit '' , Rosemary (Mannenrou), Rosehip (Nobara), Wasabi, Cottonweed Remokou
(Chiyu) and the like.

Other seawater, for example, seawater salt, dried seawater, inorganic salt obtained from the Dead Sea or the Atlantic or Pacific Ocean (sodium chloride, magnesium chloride, potassium chloride, etc.), sea mud or mud (fango) , For example, sea mud or mud of various places such as Italian Fango, German Fango, Eifel Fango, Freiburg Fango, etc. (Ingredients: silicon dioxide, titanium dioxide, aluminum oxide, iron oxide, manganese oxide, sodium oxide, potassium oxide, magnesium oxide , Calcium oxide, strontium oxide, sodium, potassium, magnesium, calcium, chromium, iron, copper, nickel, zinc, lead, manganese, arsenic,
Wed), Shotoku stone etc.

Examples of the seaweeds include seaweeds [green algae: Chlorella vulgaris, Chlorella pyrenoidosa, Chlorella ellipsoidia, Aonori (Usubaonori, Susiaonori, Hiraaonori, Bouaoonori, Hosoedaoonori), Anaaousa algae (Aosa algae), and seaweed [Aosa] Kinds: Kombu (Macambu, Rishikonbu, Hosomekombu, Mitsuikonbu), Wakame, Hirome, Ao-Wakame, Giant kelp (Macrostistis pilifera, Macrocystis integrifolia, Neocitys luetokeana), Hijiki, Hibamata, Umiuchiwa, Usubaumiuchiwa Klebanoumi prickly pear, Akaba prickly pear, Kona prickly pear, Okina prickly pear, Usuyuki prickly pear, Echinoki prickly pear], seaweed [Red algae: Hijirimen, Maxa (Tengusa), Hiracusa, Oniku , Obakusa, Kataobakusa,
Yatabegusa, Yuikiri, Shimatengusa, Tosakanori, Togekirinsai, Akumasakirinsai, Kirinsai, Junyashinkirinsai, Tsunomata, Obatsunomata, Tochaka (Yahatsutsunomata), Ezotsunomata, Togetsunomata, Hirakotonota, Kotojita
Jareus Banori, Kagius Banori, Siusius Banori, Hyus Banori, Akamomininori] and the like.

In addition, other algae such as green algae (Chlamydomonas: Chlamydomonas, Akayukimo, Dunaliella: Dunaliella, Chlorococcus: Chlorococcus, Kwanomimo: Kwanomimo, Volvox: Ohikawawari, Volvox, Palmera, Yotsumemo, Spirogyra: Hizaori, Spirogyra, Tulsimidro, Hibimidoro: Hibimidoro, Aosa: Anaoasa, Amiosa, Nagaosa, Kawanori: Kawanori,
Genus Fricciella, genus genus: medusa, asiaticum gutta, kawashiogusa, marimo, baronia: tamagobaronia, tamabaronia, tamagata: tamagatamo, iwata: husaiwata, surichogita, heraiwata, kurokita, kurokita, kurokita Sakibuchimil, Nagamir, Hiramil, and Casanori:
Casanori, Jusmo: Fusuzumo, Tamazumi,
Species of the genus Mizudzumo, Genus Genus, Genus Colecaetus, Genus genus Tsutsumo, Artemisia spp .: Artemisia spp.

Blue-green algae (Genus Lynch: L., L., L., L .: L., mushrooms,
(Hassai, Yuremo, Racenmo (Spirulina) genus: Spirulina, Trichodesmium (Aiakashio), etc.).

Brown algae (Piraella spp .: Piraella spp., Spirogyra spp .: Namiami spp., Isogrape spp .: Isogrape,
Genus Isogawara: Isogawara, Kuroshira Genus: Gunsenkurogashira, Kashirazaki Genus: Kashirazaki, Muchimo Genus: Muchimo, Hiramutimo, Kebelligsa, Amidixa Genus: Amidigsa, Sakibiroamiji, Sanadagusa: Sanadagusa, Fukurinamiji, Common Genus Artemisia spp.
Genus genus: genus pine, genus genus: genus genus: genus genus, genus okinawa, genus okinawazuku, genus phlebosum, genus phlebosum, genus phlebosum: genus futomozuku, genus genus moss: genus genus: genus kuromo, genus moss, genus genus Ishige, Irolo, Icmegasa: Ichimegasa, Keyari: Keyari, Umibos: Umibos, Urushigusa: Ursigusa,
Betula serrata, Tobacco moss, Laminaria spp. Genus Kagomenori: Kagomenori, Muraridori: Murachidori, Shakuganusa: Shakuganusa,
Genus Genus: Genus Genus, Genus Genus: Genus Genus: Genus Genus, Genus Kayamonori, Genus Genus: Genus Genus: Genus Filiformis, Genus Turmo: Genus Tsurumo, Genus Anana: Genus Anastasia, Genus Suzume: Genus Musicum, Genus Missiscoma, Genus L. , Oni-kombu, Gohei-kombu, Naga-kombu, Pea-kombu, Ochimitsu-kombu, Toro-kombu genus: Toro-kombu, Antokume genus: Antokume, Kajime genus: Kajime, Tsuruarame, Kurome, Kikuishicombu genus: Kikuishikombu, Nejirekombu: Nekorecome genus, Kuroshimae : Nekoshikambu,
Alame: Alame, Ainuwakame: Ainuwakame, Chigaiso, Oniwakameezoishige: Ezoishige, Yabanemoku: Yanemoku, Rapamoku: Rapamoku, Jiromoku: Uganomok, Jiromoku, Hiemomoku, Hokumoku, Tamamomoku, Tamamomoku Akamoku, Shidamoku, Hondawara, Nejimoku, Narasamo, Mametarawara, Tatsukuri, Yasumatamoku, Umitrano, Oobamoku, Fushizushimoku, Hahakimoku, Togemoku, Jolemoku, Saw-moku, Obanoki-mimoku, Genus genus:
Bulukimo, genus cynomolgus: cynomolgus etc.).

Red algae (Russia genus: Ushikenori, Funorinoushike, Amanori: Asakusanori, Susabinori,
Genus Upirinori, Onimanori, Tasa, Filitasa, Benitasa, Rhodocorton: Milnoveni, Akebonomozuku: Akebonomozuku, Konahada: Haikonahada, Yogorekonahada, Aokonahada, Sea Species: Acer genus, Acer genus : Larch, Fusanori: Fusanori, Nisefusanori: Nisefusanori,
Sodegarami: Sodegarami, rattles: rattle, rattle rattle, hirohatamatamaki genus: hirohatamaitadaki, tamamaidaki genus: tamaitadaki, kagikenori genus: kaginori, kakenenori, tengusa: himetenugosa, haitenugosa, haitenugosa, haitenugusaugou, haitenuganugou, haitenuganugou, haitenugusaugou Genus: hibiroudo, himehibiroudo,
Genus Isommedogi: Genus Isomomedo, Genus genus: Genus medusa, Ryumonsou: Ryumonsou, Hera Ryumon, Nisekarekususa: Genus Nisekaregusa, Okitsubara: Obaokitsubara, Akaba: Akaba, Malvaacaba, Naminohana genus
Naminohana, coral genus: rattle, mushroom, shiogosagoromo, iwanokawa: ezukiiwanokawa, kainokawa: kainokawa, kaninote: kaninote, coral genus: coral, coral, mosquito mosquito , Tambanori, slippery,
Fudarak, Malbahudarak, Isonohana: Nuracusa,
Cranouraxa, Stinging skull, Hunting genus: Hunting ibis, Hunting genus: Hunting sword, Hunting genus: Chabo kintoki, Hunting ibis, Matsunori, Komenori, Tosakamatsu, Aedes pine, Fushikintoki, Tsunomukade, Nagakinotoki, Scutellariae, Osmanthus Nagaobabane: Nagaobabane,
Genus Funori: Hanafunori, Fukurofunori, Makunori, Kalexigusa: Kalexigusa, Sasamodoki: Hosobanotosakamaki, Hirohanokasakamuki, Yatsudegatatasakamoki, Kurosakamaki, Nezashinosakamukado, Yukasakanookado Modoki,
Genus genus, genus genus: quinohada, genus esculenta: esoteka, tsukasanori genus: enashikarimenia, ootsukasanori, hanagatakarimenija, honooo genus: honoo, genus genus: lyca genus, genus genus, genus nikonobenigo Susqueke Beni, Okamuragusa:
Yamadakusa, Mirin genus: Mirin, Hosobamilin, Tosakanori genus: Kikutosaka, Ezonameshi: Ezonameshi, Isomokka genus: Isomocca, Yukari genus: Yukari, Hosoyukari, Ibaranori genus: Ibaranori, Saidaibara, Tachiibara, Kagiibanodan, Kijinotho genus Isanthus, Atsubanori: Atsubanori,
Ogonori: Ogonori, Tsurusilamo, Shiramo, Ogogonori, Mizookonori, Kabanori, Beniogonori, Fucresinori, Murasakikabanori, Shinkaikabanori, Togekabanori, Kataogonori, Ryukyuogonori, Ryokyuogonori, Ryokyuogonori, Ryokyuogonori, Ryokyuogonori , Genus Amanita: Hachijoenaga, Fushikenori genus: Fushikunori, Namiiwatake genus: Namiiwatake, scorpion genus: Scorpion genus, Occidental genus: Okutsunori, Saimi genus: Itanisa, Saimi, Harigane, Lotus japonicus:
Lotus spiders, genus genus: Ikanoashi, Hosoibonori,
Nobonori, Black Snapper: Black Snapper, Red Snapper: Red Snapper, Hishbukuro: Hishbukuro, Madaragusa: Togemadara, Echimadara, Taoyagousou: Genus Ottawa, Scrophularia , Hirata goat: Hirata goat, Dulce: Dars, Masagoshibari, Anadalus, Uebagsa: Uebagsa, Benifukuronori: Benifukuronori, Fushinagi: Fushitsunagi, Himefushinagi,
Species of the genus Hirohafushi, Snapdragons: Snapdragons, Snapdragons, Species: igis, keiigis, crickets, nigiri, amixa, egonori:
Egonori, Futogigis, Saeda: Saeda, Chrysanthemum Genus: Chrysanthemum, Konohanori Family: Habutaenori, Konohanori, Suzushironori, Usbeni: Usveni, Hasuginu: Hasuginu, Nagakonohanori: Nagakosugino, Genus: suginanu Yareusbanori, Sujiusbanori, Hyusbanori, Usubanorimodoki: Usubanorimodoki, Ayanishiki: Ayanishiki, Ayaginu:
Ayaginu, Dassia genus: Enashidazia, Simadadia genus: Isohagi, Shimadada, Dazimodoki genus: Daziomomodoki, Itogusa genus: Moletogusa, Futoigusa, Macri genus: Macri, Yanaginori genus: Hanayanagi, Yuna, Sanaginori, Mosanyugina, Sasa, Rabbitum : Kurozozo, Kobusoso, Hanezozo, Sozonohana, Hanegusa: Hanegusa, Kanegusa, Kozanemo: Kozanemo, Isomurasaki, Hosokozanemo, Himegoge: Himegoke, Kurohimegoke, Hiodoshig, Hoshigusa Suginasugusa, Isobasho Genus: Isobasho, Fujimatsumo Genus: Fujimatsumo, Sawwort: Genus Hakezakinokawa, Kawamozuku: Kawamozuku, A Kawamozuku, Himekawamozuku,
Ideyugogome: Ideyugogome, Okitimozuku: Okitimozuku, Itogusa, Chinorimo: Chinorimo, Chisginori: Chisinori, etc.).

Axle algae (Characta spp.
Hossiturimo: Hossiturimo, Lichnotumnus, Flasks: Himegrass, Chabograss, Tripera etc., Yellow algae (Hikarimo: Hikarimo etc.) and the like.

Examples of the material derived from animal raw materials include a cockscomb extract, a cow or pig, a human placenta extract, a pig or cow stomach, duodenum or intestinal extract or a decomposition product thereof, and a cow or pig spleen. Extract or its degradation product, bovine or porcine brain tissue extract, water-soluble collagen, collagen derivatives such as acylated collagen, collagen hydrolyzate, elastin, elastin hydrolyzate, water-soluble elastin derivative,
Keratin and its degradation products or their derivatives, silk protein and its degradation products or their derivatives, swine or bovine blood cell protein degradation products (globin peptides), bovine or swine hemoglobin degradation products (hemin, hematin, heme, protohem, Heme iron), milk, casein and its decomposition products or their derivatives, skim milk powder and its decomposition products or their derivatives, lactoferrin or its decomposition products, chicken egg components, fish meat decomposition products, nucleic acid-related substances (ribonucleic acid, deoxyribonucleic acid) )etc.

(14) Microbial culture metabolite Yeast metabolite, yeast extract, natto metabolite, natto extract, rice ferment extract, rice bran (red bran, white bran) ferment extract, euglena extract, raw milk or skim milk powder Lactic acid fermentation products, trehalose or derivatives thereof.

(15) α-hydroxy acids glycolic acid, citric acid, malic acid, tartaric acid, lactic acid and the like.

(16) Inorganic pigments Silicic anhydride, magnesium silicate, talc, kaolin,
Bentonite, mica, titanium mica, bismuth oxychloride, zirconium oxide, magnesium oxide, zinc oxide,
Titanium oxide, calcium carbonate, magnesium carbonate, yellow iron oxide, red iron oxide, black iron oxide, gunjou, chromium oxide,
Chromium hydroxide, carbon black, calamine, etc.

(17) UV absorber / blocker Benzophenone derivatives (2-hydroxy-4-methoxybenzophenone, 2-hydroxy-4-methoxybenzophenone-
5-sulfonic acid, 2-hydroxy-4-methoxybenzophenone-5-sulfonic acid sodium salt, dihydroxydimethoxybenzophenone, sodium dihydroxydimethoxybenzophenone-sulfonic acid salt, 2,4-dihydroxybenzophenone, tetrahydroxybenzophenone, etc.), p-aminobenzoic acid Derivatives (paraaminobenzoic acid, ethyl paraaminobenzoate, glyceryl paraaminobenzoate, amyl paradimethylaminobenzoate, octyl paradimethylaminobenzoate), methoxycinnamic acid derivatives (ethyl paramethoxycinnamate, isopropyl paramethoxycinnamate,
Octyl paramethoxycinnamate, 2-ethoxyethyl paramethoxycinnamate, sodium paramethoxycinnamate, potassium paramethoxycinnamate, mono-2-diparamethoxycinnamate
Glyceryl ethylhexanoate, etc.), salicylic acid derivatives (octyl salicylate, salicylphenyl, homomenthyl salicylate, dipropylene glycol salicylate, ethylene glycol salicylate, myristyl salicylate,
Methyl salicylate), anthranilic acid derivatives (methyl anthranilate), urocanic acid derivatives (urocanic acid, ethyl urocanate, etc.), coumarin derivatives, amino acid compounds, benzotriazole derivatives, tetrazole derivatives, imidazoline derivatives, pyrimidine derivatives, dioxane derivatives , Camphor derivative, furan derivative, pyrone derivative, nucleic acid derivative, allantoin derivative, nicotinic acid derivative, vitamin B6 derivative, umbelliferone, esculin, benzyl cinnamate, sinoxate, oxybenzone, dioxybenzone, octabenzone, slisobenzone, benzoresorcinol, arbutin Guaiazulene, shikonin, baicalin, baicalein, berberine, neoheliopan, escalol, zinc oxide, talc, kaolin and the like.

(18) Whitening agent p-aminobenzoic acid derivative, salicylic acid derivative, anthranilic acid derivative, coumarin derivative, amino acid compound,
Benzotriazole derivatives, tetrazole derivatives, imidazoline derivatives, pyrimidine derivatives, dioxane derivatives, camphor derivatives, furan derivatives, pyrone derivatives,
Nucleic acid derivatives, allantoin derivatives, nicotinic acid derivatives,
Vitamin C or derivatives thereof (vitamin C phosphate magnesium salt, vitamin C glucoside, etc.), vitamin E or derivatives thereof, kojic acid or derivatives thereof, oxybenzone, benzophenone, arbutin, guaiazulene, shikonin, baicalin, baicalein, berberine, placenta extract , Ellagic acid, lucinol and the like.

(19) Tyrosinase activity inhibitor Vitamin C or a derivative thereof (vitamin C phosphate ester magnesium salt, vitamin C glucoside or the like), hydroquinone or a derivative thereof (hydroquinone benzyl ether or the like), kojic acid or a derivative thereof, vitamin E or Derivatives thereof, N-acetyltyrosine or derivatives thereof, glutathione, hydrogen peroxide, zinc peroxide, placental extract, ellagic acid, arbutin, rucinol, silk extract, plant extract (chamomile, mulberry, gardenia, touki, warmoko,
Clara, mugwort, honeysuckle, yellowfin, amberjack, matsuhodo, adlay barley, scotch, hops, hawthorn, eucalyptus, achillea millefolium, artea, calyx, mankeishi, hamamelis, yamaguwa, extended life grass, bellflower, toshishi, maizeko, sun dried, mao, Sengoku, Dokkatsu, Psycho, Bohu, Hamabofu, Ogon, Peony, Peony, Gennoshoko, Kakkon, Licorice, Gotobiko, Aloe, Shouma, Safflower, Green Tea, Black Tea, Asenyaku).

(20) Melanin pigment reduction / decomposition substance Phenylmercury hexachlorophene, mercuric oxide, mercurous chloride, aqueous hydrogen peroxide, zinc peroxide, hydroquinone or a derivative thereof (hydroquinone benzyl ether)
etc.

(21) Turnover promoting action / cell activator hydroquinone, lactic acid bacteria extract, placenta extract, reishi extract, vitamin A, vitamin E, allantoin, spleen extract, thymus extract, yeast extract, fermented milk extract, plant extract (Aloe, Ogon, horsetail, gentian, burdock,
Sicon, carrot, hamamelis, hop, yokunin,
Odrich, Assemble, Touki, Calendula officinalis, Amacha, Hypericum perforatum, Cucumber, Periwinkle,
Rosemary, parsley) etc.

(22) Astringent succinic acid, allantoin, zinc chloride, zinc sulfate, zinc oxide, calamine, zinc p-phenolsulfonate, aluminum potassium sulfate, resorcinol, ferric chloride, tannic acid (including catechin compound) etc.

(23) Active oxygen scavenger SOD, catalase, glutathione peroxidase and the like.

(24) Antioxidants Vitamin C or a salt thereof, stearic acid ester, vitamin E or a derivative thereof, nordihydroguaselethenoic acid, butylhydroxytoluene (BHT), butylhydroxyanisole (BHA), hydroxytyrosol, Parahydroxyanisole, propyl gallate, sesamol,
Sesamolin, gossypol, propolis, etc.

(25) Lipid peroxide production inhibitor β-carotene, plant extract (cultured sesame cells, amateur,
Hypericum, Hamamelis, Clove, Melissa, Emisoso, Birch, Salvia, Rosemary, Minami Tenji, Agetsu, Ginkgo, Green Tea) and the like.

(26) Anti-inflammatory agent Ictamole, indomethacin, kaolin, salicylic acid, sodium salicylate, methyl salicylate, acetylsalicylic acid, diphenhydramine hydrochloride, d-camphor,
dl-camphor, hydrocortisone, guaiazulene, camazulene, chlorpheniramine maleate, glycyrrhizic acid or a salt thereof, glycyrrhetinic acid or a salt thereof, licorice extract, sicon extract, age extract, propolis and the like.

(27) Antibacterial, bactericidal and disinfecting agents acrinol, sulfur, calcium gluconate, chlorhexidine gluconate, sulfamine, mercurochrome, lactoferrin or a hydrolyzate thereof, alkyl diaminoethyl glycine chloride solution, triclosan, sodium hypochlorite, Chloramine T, salad powder, iodine compound,
Iodoform, sorbic acid or a salt thereof, salicylic acid, dehydroacetic acid, parahydroxybenzoic acid esters, undecylenic acid, thiamine lauryl sulfate, thiamine lauryl nitrate, phenol, cresol, p-chlorophenol, p-chloro-m-xylenol, p-chloro-m-cresol, thymol, phenethyl alcohol, o-phenylphenol, irgasan CH3565, halocarban, hexachlorophen, chlorohexidine, ethanol, methanol, isopropyl alcohol, benzyl alcohol, ethylene glycol, propylene glycol, phenoxyethanol, chlorobutanol, Isopropyl methyl phenol, nonionic surfactants (polyoxyethylene lauryl ether, polyoxyethylene nonyl phenyl ether, polyoxyethylene Octyl phenyl ether, etc.), amphoteric surfactants, anionic surfactants (sodium lauryl sulfate, potassium lauroyl sarcosine, etc.),
Cationic surfactants (cetyltrimethylammonium bromide, benzalkonium chloride, benzethonium chloride, methylrosaniline chloride), formaldehyde, hexamine,
Brilliant Green, Malachite Green, Crystal Violet, Jarmal, Photosensitizer 101, Photosensitizer 201, Photosensitizer 401, N-long-chain acyl basic amino acid derivatives and their acid addition salts, zinc oxide, hinokitiol, kudin, propolis, etc. .

(28) Humidifier Glycerin, propylene glycol, 1,3-butylene glycol, hyaluronic acid or its salt, polyethylene glycol, chondroitin sulfate or its salt, water-soluble chitin or chitosan derivative, pyrrolidone carboxylic acid or its salt, lactic acid Sodium, Mini Sasanishiki extract, Bacillus natto metabolite, Natto extract, Loofah water, Birch (birch) or Sap of Akamatsu

(29) Elastase activity inhibitor diisopropyl fluorophosphate, plant extracts (Ougon, Hypericum perforatum, Clara, mulberry leaves, calyx, Gennoshoko, comfrey, salvia, Atlantic elderberry, bollige, buttonpi), seaweed extract and the like.

(30) Hair preparations Selenium disulfide, alkylisoquinolinium bromide solution, zinc pyrithione, biphenamine, thianthol, castal tincture, ginger tincture, capsicum tincture, quinine hydrochloride, strong aqueous ammonia, potassium bromate, bromate Sodium, thioglycolic acid and the like.

(31) Antiandrogens Estrogen (estrone, estradiol, ethinylestradiol, etc.), isoflavones, oxendrone, etc.

(32) Peripheral vascular blood flow promoter Vitamin E or a derivative thereof, assembly extract, garlic extract, carrot extract, aloe extract, gentian extract, touki extract, cepharanthin, carpronium chloride, minoxidil and the like.

(33) Stimulants Pepper tincture, vanillamide nonylate, tincture tincture, tincture tincture, peppermint oil, l-menthol, camphor, benzyl nicotinate and the like.

(34) Metabolic activators Photosensitizer No. 301, hinokitiol, pantothenic acid or a derivative thereof, allantoin, placental extract, biotin, pentadecanoic acid glyceride and the like.

(35) Antiseborrheic agent pyridoxine or a derivative thereof, sulfur, vitamin B6
etc.

(36) Keratolytic agents Resorcin, salicylic acid, lactic acid and the like.

(37) Oxidizing agent Hydrogen peroxide solution, sodium persulfate, ammonium persulfate, sodium perborate, urea peroxide, sodium percarbonate, sodium tripolyphosphate, sodium bromate, potassium bromate, pyrroline peroxide Sodium silicate, sodium orthophosphate, sodium silicate hydrogen peroxide adduct, sodium sulfate hydrogen peroxide adduct, sodium chloride hydrogen peroxide adduct, β-tyrosinase enzyme solution,
Mushroom extract and the like.

(38) Hair remover Strontium sulfate, sodium sulfide, barium sulfide,
Inorganic reducing agents such as calcium sulfide, thioglycolic acid or salts thereof (calcium thioglycolate, sodium thioglycolate, lithium thioglycolate, magnesium thioglycolate, strontium thioglycolate) and the like;

(39) Hair swelling agent Ethanolamine, urea, guanidine and the like.

(40) Dyes 5-aminoorthocresol, 2-amino-4-nitrophenol, 2-amino-5-nitrophenol, 1-amino-4-methylaminoanthraquinone, 3,3'-iminodiphenol ,
2,4-diaminophenoxyethanol hydrochloride, 2,4-diaminophenol hydrochloride, toluene-2,5-diamine hydrochloride, nitroparaphenylenediamine hydrochloride, paraphenylenediamine hydrochloride, N-phenylparaphenylenediamine hydrochloride, metaphenylenediamine hydrochloride, ortho Aminophenol, N-phenylparaphenylenediamine acetate, 1,4-diaminoanthraquinone, 2,6-diaminopyridine, 1,5-dihydroxynaphthalene, toluene-2,5-diamine, toluene-3,4-
Diamine, nitroparaphenylenediamine, paraaminophenol, paranitroorthophenylenediamine, paraphenylenediamine, paramethylaminophenol,
Picramic acid, sodium picramate, N, N'-bis (4-aminophenyl) -2,5-diamino-1,4-quinonediimine, 5- (2-hydroxyethylamino) -2-methylphenol, N-phenyl Paraphenylenediamine, metaaminophenol, metaphenylenediamine, 5-aminoorthocresol sulfate, 2-amino-5-nitrophenol sulfate,
Orthoaminophenol sulfate, orthochloroparaphenylenediamine sulfate, 4,4'-diaminodiphenylamine sulfate, 2,4-diaminophenol sulfate, toluene-2,5-sulfate
Diamine, nitroparaphenylenediamine sulfate, paraaminophenol sulfate, paranitroorthophenylenediamine sulfate, paranitrometaphenylenediamine sulfate, paraphenylenediamine sulfate, paramethylaminophenol sulfate, metaaminophenol sulfate, metaphenylenediamine sulfate, catechol, diphenylamine , Α-naphthol, hydroquinone, pyrogallol, phloroglucin, gallic acid, resorcin, tannic acid, 2-hydroxy
Sodium 5-5-nitro-2 ', 4'-diaminoazobenzene-5'-sulfonate, hematein and the like.

(41) Flavors Natural animal flavors such as musk, civet, castorium, ambergris, anise essential oil, angelica essential oil, ylang-ylang essential oil, iris essential oil, fennel essential oil, orange essential oil, cananga essential oil, caraway essential oil, cardamom essential oil, Guaiac wood essential oil, cumin essential oil, black letter essential oil, cinnamon essential oil, cinnamon essential oil, geranium essential oil, copaiba balsam essential oil, coriandel essential oil, perilla essential oil, cedarwood essential oil, citronella essential oil, jasmine essential oil, ginger grass essential oil, cedar essential oil, spearmint essential oil, western Mentha essential oil, Fengqiang essential oil, Tuberose essential oil, T-shaped essential oil, Orange flower essential oil, Winter green essential oil, Truval sam essential oil, Batuuri essential oil, Rose essential oil, Palmarosa essential oil, Cypress essential oil, Hiba essential oil,
Sandalwood essential oil, Petit glen essential oil, Bay essential oil, Vetiva essential oil, Bergamot essential oil, Peruvian balsam essential oil, Boad rose essential oil, Camphor essential oil, Mandarin essential oil, Eucalyptus essential oil, Lime essential oil, Lavender essential oil, Linaloe essential oil, Lemon grass essential oil, Lemon essential oil, Rosemary Vegetable flavors such as essential oils and Japanese peppermint essential oils, and other synthetic flavors.

(42) Dyes / Colorants Red cabbage dye, red rice dye, madder dye, anato dye, squid dye, turmeric dye, ende dye, krill dye, persimmon dye, caramel, gold, silver, gardenia dye, corn dye , Onion pigment, tamarind pigment, spirulina pigment, buckwheat whole plant pigment, cherry pigment, laver pigment, hibiscus pigment, grape juice pigment, marigold pigment, purple potato pigment, purple yam pigment, lac pigment, rutin and the like.

In addition, humectants, hormones, sequestering agents, pH adjusters, chelating agents, preservatives / anti-binders, fresheners, stabilizers, emulsifiers, animal and plant proteins and their decomposition products, animal and plant Vegetable polysaccharides and their degradation products, animal and vegetable glycoproteins and their degradation products, blood flow enhancers, anti-inflammatory and anti-allergic agents, cell activators, keratolytic agents, wound healing agents, foam enhancers, thickeners Agents, oral agents, deodorants / deodorants, bittering agents, seasonings, enzymes, and the like can be used, and when used in combination therewith, various additive and synergistic effects can be expected.

Further, the dosage form of the antioxidant, humectant or cosmetic composition of the present invention is arbitrary and includes capsules, powders, granules, solids, liquids, gels, air bubbles, emulsions, creams, ointments, sheets and the like. It can be in the form.

Specifically, for example, basic preparations such as medicinal preparations for external use, lotions, emulsions, creams, ointments, lotions, oils, packs, etc .; , Pre-show lotion, shaving cream, shampoo, rinse,
Hair treatments, hair styling agents, perm agents, hair tonics, hair dyes, hair growth / hair restorations, etc., makeup cosmetics such as foundations, lipsticks, blushers, eye shadows, eyeliners, mascaras, perfumes, bath agents , Other, toothpaste, mouth freshener / gargle, deodorant,
Various products such as deodorants, sanitary cotton, and wet tissues can be used, and can be blended into general foods and drinks.

The method of adding to the antioxidant, humectant or cosmetic composition of the present invention may be added in advance or during the production, and may be appropriately selected in consideration of workability. Just do it.

[0078]

EXAMPLES The present invention will now be described with reference to Production Examples, Test Examples and Formulation Examples, but the present invention is not limited thereto.

(Production Example 1) Silane, sasabagin orchid, rhinoceros, hetsukaran, sulgaran, shunlan, kanran, kinryohen, hosairan, hakusanchidori, Dactylorhizaincarnata, sakurasekokuk, sekikoku, koukisekoku, honsekoku, ezozora, suzugane, aosuzurana ,
100 g of each plant of Onoelan, Ucholan, Grey-headed Butterfly, and Vanilla was heated and extracted with purified water (about 80 ° C.) for about 5 hours, filtered and extracted (dry solids: about 0.1 to 3.0%).
%) Of about 1.0-3.0 kg.

(Production Example 2) Silane, sasabagin orchid, rhinoceros, hetsukaran, sulgaran, shunlan, kanran, kinryohen, housairan, haksanchidori, Dactylorhizaincarnata, sakurasekokuk, sekokuk, koukisekoku, honsekoku, ezozuran, aosuzurana, aosuzurani ,
100 g of each plant of Onoelan, Butterfly Orchid, Grey-headed Butterfly, and Vanilla is immersed in a 50% ethanol solution, extracted at room temperature for 5 days and nights, and then filtered to obtain an extract (dry solid content: about 0.1-3.0%) of about 1.0- Get 3.0kg.

(Production Example 3) Silane, sasabagin orchid, saihairan, hetskalan, sulgaran, shunlan, kanran, kinryohen, housairan, haksanchidori, Dactylorhizaincarnata, sakurasekokuk, sekokuk, koukisekok, honsekok, ezozranz, aosuzurana ,
100 g of each plant of Onoelan, Ucholan, Grey-headed Butterfly, and Vanilla each at 50 ° C in an equal volume mixture of 30% propylene glycol solution and 30% 1,3-butylene glycol solution
And slowly extract with warming for 6 hours, and suction-filter to obtain about 1.0-3.0 kg of extract (dry solid content: 0.2-3.5%).

(Production Example 4) Silane, sasabagin orchid, rhinoceros, hetsukaran, sulgaran, shunlan, kanran, kinryohen, hosaisairan, sakusanchidori, Dactylorhizaincarnata, sakurasekokuk, sekikoku, koukisekoku, honsekoku, suzuranzia, aosuzurani, aosuzurana ,
100 g of each of Onoelan, Ucholan, Gyrophoenix, and Vanilla plants in 30% ethanol solution or 45% 1,3-
After immersion in butylene glycol solution or 50% propylene glycol solution or purified water (about 30 ° C.) and extraction at room temperature for 5 days and nights, filtration and extraction (dry solid content: about 0.1 to
2.5%) of about 1.0-3.0 kg.

(Test 1) Moisturizing Property of Plant Extract 1 In order to evaluate the moisturizing property of the plant extract of the present invention, the change over time of the water content of the stratum corneum by a monitor was determined by measuring the electric conductivity.

(Sample solution) Extract of purified water from each plant (adjusted to a solid content of 0.01%) (Measuring instrument) IMPEDANCE METER SKICON-200; manufactured by IBS Corporation (Monitor) 20-year-old woman, 22-year-old woman, 24 (Test environment) 24 ° C, 50% RH (Method) One hour before the test, enter the monitor in a thermo-hygrostat adjusted to the test environment and stabilize it. afterwards,
Apply each sample solution (1 mL) to the forearm flexion side of the monitor,
After seconds, excess water is removed and the electrical conductivity of the stratum corneum is measured over time.

FIGS. 1 to 6 show the results. It was found that the plant extract according to the present invention had a higher moisturizing effect and was maintained for a longer time than the aloe vera extract having the same solid content (comparative example).

(Test 2) Moisturizing property 2 of plant extract In order to evaluate the moisturizing property of the plant extract of the present invention, the change over time of the transepidermal water loss with a monitor was measured.

(Sample solution) Aqueous solution of 30% EtOH extract of each plant (adjusted to a solid concentration of 0.01%) (Measurement instrument) TEWAMETER TM210; COURAGE + KHAZAKA Elect
ronic Gmbh (monitor) 23-year-old woman, 29-year-old man, 24-year-old woman, 35-year-old woman, 35-year-old man (Method) Apply the aqueous solution (1 mL) of each sample to the left and right forearms flexibly three times a day. After the third application, after stabilizing for 1 hour in a thermo-hygrostat (24 ° C., 50% RH), measurement of transepidermal water loss is started. The measurement is performed at intervals of 2 seconds for 3 minutes, and the average value of all the numerical values is defined as the TEWL value of the test site.
Each blank was measured under the same conditions before sample application.

Table 1 shows the results of the average water change of the five monitors. It has been found that the plant extract according to the present invention suppresses transepidermal water evaporation and exhibits a good moisturizing effect.

(Test 3) Elimination of active oxygen (SOD-like activity)
Action test In recent years, many diseases and diseases induced by active oxygen have been reported, and it has been pointed out that removal and elimination of active oxygen leads to prevention of tissue damage. In this test,
The active ingredient of the present invention obtained in Production Example 2 was evaluated for its ability to eliminate active oxygen generated by the xanthine-xanthine oxidase system using the nitro blue tetrazolium method (Lipid peroxide experiment method, p. Publishing Co., Ltd.)
It was examined by.

"Testing method and evaluation method" [0108] To 2.5 mL of a 0.05 M sodium carbonate buffer (pH 10.2) containing 1.0 mM xanthine and 3.0 mM disodium ethylenediaminetetraacetate was added.
Add 75 mM nitro blue tetrazolium, 0.15 W / V% bovine serum albumin, and 0.1 mL of each sample solution, and leave at 25 ° C. for 10 minutes. There is a xanthine oxidase aqueous solution 0.1m which was adjusted so that the absorbance change was about 0.3 / 20 minutes in advance.
After L was added and left at 25 ° C. for 20 minutes, the reaction was stopped with a 6 mM CuCl solution, and the absorbance at 560 nm was measured. In addition, the results obtained by determining the inhibition rate by Equation 1 using the group containing the reaction stop solution before adding xanthine oxidase as a blank for each sample and control as a control, and adding the solvent of the sample solution instead of the sample as a control. As shown in FIG.

"Sample" The sample was prepared by preparing a 45% 1,3-butylene glycol solution extract of each plant so as to have a solid content concentration of 0.5%, and was subjected to a test. As a control, extracts extracted from peonies and hops which are known to have active oxygen scavenging ability by the same production method were used for the test.

<Equation 1> Active oxygen scavenging rate (%) = {1− (sample OD value−blank (sample) OD value) / (control OD value−blank (control) OD value)} ×
100

(Test Results) As shown in FIG. 7, the product of the present invention showed a stronger ability to scavenge active oxygen than the control. Therefore, the product of the present invention is considered to be useful as an active oxygen scavenger.

(Test 4) Lipid Peroxide Production Inhibition Test Lipid peroxide is a product obtained by oxidizing unsaturated fatty acids, which may damage cell membranes in vivo, inactivate various enzymes, or denature biological proteins. And so on. As a result, various adverse effects on living tissues such as acceleration of aging and cancerous changes are reported. In the skin, for example, the accumulation of lipid peroxides caused by the peroxidation of sebum causes changes in the cell membrane and mitochondrial functions of the skin,
It is said to not only induce symptoms such as melasma, primary irritant dermatitis, and atopic dermatitis, but also promote skin aging such as rough skin, wrinkles, and senile pigmentation. Suppression is regarded as important in dermatology. In this test, the amount of peroxide of linolenic acid generated by ultraviolet rays was measured by using the TBA method (Analytical, Biochemistry. Vol. 95, P351-358 (1979)), and obtained in Production Example 2. The antioxidant effect of the active ingredient of the present invention was examined.

[Test Method and Evaluation Method] A solution obtained by dissolving 0.1% linolene in 0.8% sodium lauryl sulfate
To 4.9 mL, add 0.1 mL of the test sample and irradiate with ultraviolet light for 1 hour. 1 mL of this reaction solution is placed in a centrifuge tube containing dibutylhydroxytoluene as a reaction terminator, 1 mL of thiobarbituric acid solution is added thereto, and the mixture is heated at 95 ° C. for 1 hour. After cooling, 4 mL of a butanol solution was added, shaken well, centrifuged, and the absorbance of the butanol layer at 532 nm was measured.
In addition, the solvent to which the solvent was added was used as a control, and a blank which was not irradiated with ultraviolet rays was set for each sample and the control. The results are shown in FIG. "Sample" The sample was prepared by preparing a 45% 1,3-butylene glycol solution extract of each plant so as to have a solid concentration of 0.5%, and was subjected to a test. As a comparative sample, dl-α-
Tocopherol 0.05% was used for the test.

<Equation 2> Lipid peroxide production inhibition rate (%) = ｛1− (sample OD value−blank (sample) OD value) / (control OD value−blank (control) OD)
Value)} × 100

(Test Results) As shown in FIG. 8, the product of the present invention was found to have a strong inhibitory effect on lipid peroxide production. Therefore, the product of the present invention is considered to be useful as an antioxidant.

(Test 5) Safety test (1) Primary skin irritation test The product of the present invention obtained in Production Examples 1 to 4 was prepared with purified water so that the dry solid concentration was about 1.0%. It was applied to the skin of Japanese white rabbits (female, 3 per group, weighing about 2.3 kg) whose back was shaved. The judgment was made 24, 48, and 72 hours after application by the primary irritation scoring method using erythema and edema as indices. The result was negative in all animals without any erythema and edema.

(Test 6) Safety test (2) Skin cumulative irritation test Similarly, the product of the present invention obtained in Production Examples 1 to 4 was prepared with purified water so as to have a dry solid concentration of about 1.0%. Hartley guinea pig with shaved flank (female, 3 per group)
Once a day, 5 times a week, 0.5 mL
/ Animal was applied. Application was performed over two weeks and shaving was performed on the last application day of each week. The determination was made on the day following each application day and the day after the last application day by using the primary irritancy scoring method with erythema and edema as indices. The result is 2 in all animals.
No erythema and edema were observed over the course of the week, and the test was judged negative.

(Test 7) Safety test (3) Acute toxicity test Similarly, a powder (dry solid content: about 1.0%) obtained by concentrating and drying the product of the present invention obtained in Production Examples 1 to 4 under reduced pressure was dried. Before the test, ddy mice fasted for 4 hours (male and female,
2,000 mg / kg was orally administered to a group (5 animals, 5 weeks old) at a dose of 2,000 mg / kg. as a result,
No abnormalities were observed in all mice for 14 days, and
The dissection results were not abnormal. Therefore, LD50 is 2,000mg
/ Kg or more.

(Formulation Examples) Production of Various Cosmetic Compositions The following formulation examples are shown in accordance with the above evaluation results. Was.

(Formulation Example 1) Emulsion weight% 1. Squalane 8.0 2. Jojoba oil 7.0 3. Cetyl alcohol 1.5 4. Glycerin monostearate 2.0 5. Polyoxyethylene (20) cetyl ether 3.0 6. Polyoxyethylene (20 ) Sorbitan monooleate 2.0 7.1,3-butylene glycol 1.0 8. Glycerin 2.0 9. A: Extract of silane 45% 1,3-butylene glycol B: Sasabagin orchid 45% 1,3-butylene glycol extract C: Saihylan 45% 1 , 3-butylene glycol extract D: Hetsukaran 45% 1,3-butylene glycol extract E: Sulgaran 45% 1,3-butylene glycol extract F: Shunlan 45% 1,3-butylene glycol extract G: Kanlan 45 % 1,3-butylene glycol extract H: Golden hen 45% 1,3-butylene glycol extract I: Bosailan 45% 1,3-butylene glycol extract J: Hakusan plover 45% 1,3-butyl Glycol extract K: Dactylorhiza incarnata 45% 1,3-butylene glycol extract L: Sakurasekoku 45% 1,3-butylene glycol extract M: Secoc 45% 1,3-butylene glycol extract N: Koukisekoku 45% 1,3-butylene glycol extract O: Hongsekku 45% 1,3-butylene glycol extract P: ezotuzuran 45% 1,3-butylene glycol extract Q: Aozudran 45% 1,3-butylene glycol extract R: Tsuchiakebi 45% 1,3-butylene glycol extract S: Oninoyaga 45% 1,3-butylene glycol extract T: Sakanelan 45% 1,3-butylene glycol extract U: Onoelan 45% 1,3-butylene glycol extract V : 45% 1,3-butylene glycol extract from orchid lanthanum W: 45% 1,3-butylene glycol extract from nymph butterflies X: 45% 1,3-butylene glycol extract from vanilla ※ A to X Extract or component 5.0 10. Preservative (p-hydroxybenzoate) qs 11. perfume qs 12. Purified water 100

(Formulation Example 2) Emulsion weight% 1. Squalane 8.0 2. Jojoba oil 7.0 3. Glyceryl paraaminobenzoate 1.0 4. Ethyl urocanate 1.0 5. Magnesium salt of vitamin C phosphate ester 1.0 6. Cetyl alcohol 1.5 7. Glycerin monostearate 2.0 8. Polyoxyethylene (20) cetyl ether 3.0 9. Polyoxyethylene (20) soorbitan monooleate 2.0 10.1,3-butylene glycol 1.0 11. Glycerin 2.0 12. Sasabagin orchid 45% 1,3- Butylene glycol extract 3.0 13. Dactylorhiza incarnata 45% 1,3-butylene glycol extract 3.0 14. Aozuran 45% 1,3-butylene glycol extract 3.0 15. Sakanelan 45% 1,3-butylene glycol extract 3.0 16. Hot water extract 3.0 17. Preservative (p-hydroxybenzoate) qs 18. Residual with purified water 100

(Formulation Example 3) Cosmetic oil weight% 1. Liquid paraffin 30.0 2. Squalane 20.0 3. Olive oil 20.0 4. Isopropyl palmitate 10.0 5. Grapefruit fruit or leaf hot water extract 3.0 6. Glycerin 30% glycerin extraction Liquid 3.0 7. Gulf hummingbird 30% glycerin extract 3.0 8. Onoelan 30% glycerin extract 2.0 9. Olive oil 1.0 10. Shea fat 1.0 11. Butylhydroxyanisole 0.1 12. Vitamin E derivative 0.1 13. Preservative (benzalkonium chloride) ) Suitable amount 14. Fragrance (musk water) Appropriate amount 15. Purified water 100 residue

(Formulation Example 4) Flexible lotion% by weight 1. Glycerin 5.0 2.1,3-butylene glycol 5.0 3. Polyoxyethylene sorbitan monolaurate (20E.O) 1.0 4. Ethanol 15.0 5. Extraction of 30% ethanol with Hetcalane Liquid 1.0 6. sulgaran 30% ethanol extract 1.0 7. lanthanum 30% 1,3-butylene glycol extract 1.0 8. snapdragon 30% 1,3-butylene glycol extract 1.0 9. chungran 45% 1,3-butylene glycol Extract 1.0 10. Red willow 50% ethanol extract 1.0 11. Ilex Guayusa 50% ethanol extract 1.0 12. Antibacterial and preservative (lactoferrin solution) qs 13. perfume (western thin water) qs 14. Purified water 100 Residue

(Formulation Example 5) Astringent lotion weight% 1. Sorvitol 2.0 2. POE (20) oleyl alcohol 1.0 3. Ethanol 15.0 4. Kokkiseki 50% 1,3-butylene glycol extract 2.0 5. Sasabagin orchid 50% Ethanol extract 2.0 6. Sihylan 50% ethanol extract 2.0 7. Sekko 45% 1,3-butylene glycol extract 2.0 8. Allantoin 0.2 9. Astringent (zinc sulfocarbonate) 0.2 10. Antibacterial and preservative (thiamine lauryl) Sulfate) Appropriate amount 11. Fragrance (lavender water) Appropriate amount 12. Purified water 100 residue

(Formulation Example 6) Two-layer type lotion (liquid to liquid type)% by weight 1. Squalane 8.0 2. POE sorbitan tetraoleate 0.3 3. Sorbit 1.0 4. Ethanol 15.0 5. Extraction with 30% ethanol Liquid 1.0 6. Honsecoku 30% glycerin extract 1.0 7. Aozuran 30% glycerin extract 1.0 8. Silane 30% 1,3-butylene glycol extract 1.0 9. Ascorbic acid 0.2 10. Astringent (calamine) 0.1 11. Preservative Reagent (phenoxyethanol) qs 12. Flavor (lemon water) qs 13. Purified water 100 residue

(Formulation Example 7) Carmine lotion (liquid to solid)% by weight 1. Glycerin 3.0 2.1,3-butylene glycol 5.0 3. Ethanol 15.0 4. Iron oxide (Bengara) 0.2 5. Zinc oxide 0.5 6. Kaolin 2.0 7. 50% propylene glycol extract from Pleurotus cerevisiae 2.0 8. 50% propylene glycol extract from Oninoyaga 2.0 9. 50% propylene glycol extract from hosailan 2.0 10. 30% onoelane ethanol solution 2.0 11. Placenta extract 2.0 12. Camphor 0.2 13. Phenol 0.03 14. Preservative (Photosensitizer 201 & 401) Appropriate amount 15. Fragrance (Bodhi tree water) Appropriate amount 16. Purified water 100 residue

(Formulation Example 8) Pack weight% 1. Polyvinyl alcohol 15.0 2. Sodium carboxymethylcellulose 5.0 3. Propylene glycol 3.0 4. Ethanol 10.0 5. Hexcalane 50% ethanol extract 2.0 6. Shunlan 50% ethanol extract 2.0 7 .Surgalane 50% ethanol extract 2.0 8. Kanran 50% ethanol extract 2.0 9. Kinchohen 50% ethanol extract 2.0 10. Silane 30% ethanol extract 2.0 11. Horaisan 30% ethanol extract 2.0 12. Preservative (Paraoxybenzoate) Appropriate amount 13.Fragrance (Toki water) Appropriate amount 14.Purified water 100 residue

(Formulation Example 9) Peel-off pack% by weight 1. Glycerin 5.0 2. Propylene glycol 4.0 3. Polyvinyl alcohol 15.0 4. Ethanol 8.0 5. Polyoxyethylene glycol 1.0 6. Pantothenyl ethyl ether 1.0 7. Hakusan plover 30% Ethanol extract 2.0 8. 50% ethanol extract from Hong Kong 2.0 9. 50% ethanol extract 2.0 10. Appropriate preservative (paraoxybenzoate) 11. Perfume (Hiba water) Appropriate amount 12. Purified water 100

(Formulation Example 10) Cold cream weight% 1. Salicone beeswax 11.0 2. Liquid paraffin 22.0 3. Lanolin 10.0 4. Olive oil 5.0 5. Chamomile oil 5.0 6. Palm oil 5.0 7. Borax 0.5 8. Dactylorhiza incarnata extraction Liquid 2.0 (Ethanol: 1,3-butylene glycol = 1: 1 extraction solvent) 9.Kokuseki extract 2.0 (Ethanol: 1,3-butylene glycol = 1: 1 extraction solvent) 10.Ezosuzuran extract 2.0 (Ethanol: 1,3-butylene glycol = 1: 1 extraction solvent) 11. Liquid shea fat 1.0 12. Preservative (acrinol) 0.1 13. Perfume (sage water) Appropriate amount 14. Purified water 100 residue

(Formulation Example 11) Emollient cream% by weight 1. Stearic acid 2.0 2. Stearyl alcohol 7.0 3. Reduced lanolin 2.0 4. Squalane 5.0 5. Octyldodecanol 6.0 6. Polyoxyethylene cetyl ether (25E.O.) 3.0 7. Lipophilic glyceryl monostearate 2.0 8. Propylene glycol 5.0 9. Honsecoku 45% 1,3-butylene glycol extract 3.0 10. Vanilla 45% 1,3-butylene glycol extract 3.0 11. Oninoyagara 45% 1, 3-butylene glycol extract 3.0 12. 45% 1,3-butylene glycol extract 3.0 13. preservative (paraben) qs 14. perfume (cinch water) qs 15. purified water 100

(Formulation Example 12) Face Wash Cream% by Weight 1. Myristic acid 25.0 2. Stearic acid 5.0 3. Tallow fatty acid 5.0 4. Propylene glycol 10.0 5. Potassium hydroxide 6.0 6. Coconut oil fatty acid diethanolamide 6.0 7. Aozuran extraction Liquid 2.0 (Ethanol: 1,3-butylene glycol = 1: 2 extraction solvent) 8. Onoelan hot water extract 2.0 9. Vanilla 30% propylene glycol extract 2.0 10. Loofah fruit or stem 50% 1,3-butylene glycol Extract 2.0 2.0 Dipotassium glycyrrhetinate 1.0 12. Preservative (salicylic acid) 0.1 13. Appropriate amount of fragrance (sage water)

(Formulation Example 13) Face wash cream weight% 1. stearic acid 10.0 2. palmitic acid 10.0 3. myristic acid 12.0 4. lauric acid 4.0 5. oleyl alcohol 1.5 6. lanolin derivative (EO adduct) 1.0 7. glycerin 18.0 8. Potassium hydroxide 6.0 9. A: Silane extract of Production Example 3 B: Sasabagin orchid extract of Production Example 3 C: Saihyran extract of Production Example 3 D: Hetsukaran extract of Production Example 3 E: Production Example 3 F: Shunran extract of Production Example 3 G: Kanran extract of Production Example 3 H: Goldfish extract of Production Example 3 I: Bosairan extract of Production Example 3 J: Hakusanchidori extract of Production Example 3 K: Dactylorhiza incarnata extract of Production Example 3 L: Sakuraseki extract of Production Example 3 M: Pepper extract of Production Example 3 N: Kokkiseki extract of Production Example 3 O: Hongsekkoku extract of Production Example 3 : Ezosuzuran extract of Production Example 3 Q: Azusulane extract of Production Example 3 R: Pleuronella edulis extract of Production Example 3 S: Ponifera extract of Production Example 3 T: Sakaneran extract of Production Example 3 U: Product of Production Example 3 Onoelan extract V: Butterfly orchid extract of Production Example 3 W: Ginkgo Butterfly extract of Production Example 3 X: Vanilla extract of Production Example 3 * Any one of A to X extract or component 5.0 10. Glycyrrhetinic acid 1.0 11 .Preservative (salicylic acid) 0.1 12.Perfume (Toki water) Appropriate amount 13.Purified water 100 residue

(Formulation Example 14) Body soap weight% 1. Potassium laurate 15.0 2. Potassium myristate 5.0 3. Propylene glycol 5.0 4. Whey 1.5 5. 45% sulgalane 1,3-butylene glycol extract 1.0 6. Shunlan 45% 1,3-butylene glycol extract 1.0 7. Kanran 45% 1,3-butylene glycol extract 1.0 8. Gourd 45% 1,3-butylene glycol extract 1.0 9. Polyethylene powder 0.5 10. Hydroxypropyl chitosan Solution 0.5 11. Amino acid (glycine, glutamine, etc.) 0.5 12. Preservative (undecylenic acid, phenol) proper amount 13. pH adjuster proper amount 14. Fragrance (lavender water) proper amount 15. Purified water 100 residue

(Formulation Example 15) Sunscreen cosmetics (O / W type)% by weight 1. Oxybenzone 2.0 2. Octyl paramethoxycinnamate 5.0 3. Squalane 10.0 4. Vaseline 5.0 5. Stearyl alcohol 3.0 6. Stearic acid 3.0 7. Glyceryl monostearate 2.0 8. Polyethyl acrylate 1.0 9.1,3-butylene glycol 6.0 10. Disodium edetate 0.1 11. Triethanolamine 1.0 12. Titanium dioxide 5.0 13. Shunran 50% dipropylene glycol extract 0.5 14. Onoelan 50% dipropylene glycol extract 0.5 15. Silane 50% dipropylene glycol extract 0.5 16. Butterfly lanthanum 50% dipropylene glycol extract 0.5 17. Mulberry bark 50% dipropylene glycol extract 0.5 18. Purple root 50 % Dipropylene glycol extract 0.5 19. Preservative (paraben) qs 20. Flavor (apple water) qs 21. Purified water 100 Residue

(Formulation Example 16) Sunscreen cosmetics (oil type)% by weight 1. Liquid paraffin 70.0 2. Ethyl paraaminobenzoate 1.0 3. Tetrahydroxybenzophenone 1.0 4. Cetyl octanoate 25.0 5. Sasabagin orchid 45% 1,3 -Butylene glycol extract 2.0 6. Dactylorhiza incarnata 45% 1,3-butylene glycol extract 2.0 7.Hetsukaran 45% 1,3-butylene glycol extract 2.0 8. Kanran 45% 1,3-butylene glycol extract 2.0 9. Saxifrage whole plant 30% 1,3-butylene glycol extract 0.5 10. Adlay whole plant 50% 1,3-butylene glycol extract 0.5 12. Fenka fruit 30% 1,3-butylene glycol extract 2.0 12. Antioxidant (Butyl hydroxytoluene) Appropriate amount 13.Perfume (Bodyju water) Appropriate amount

(Formulation Example 17) Cream foundation (O / W type) weight% 1. stearic acid 4.0 2. glyceryl monostearate 3.0 3. cetanol 1.5 4. isopropyl myristate 7.0 5. liquid paraffin 10.0 6. salami beeswax 3.0 7. Triethanolamine 1.5 8. Glycerin 3.0 9. Bentonite 1.0 10. Titanium oxide 8.0 11.2,4-dihydroxybenzophenone 8.0 12. Kaolin 3.0 13. Talc 3.0 14. Color pigment (iron iron oxide) 1.0 15. Sakurasekoku hot water Extracted dry powder 0.2 16.Ricciaceae hot water extracted dry powder 0.217 Oninoyagara hot water extracted dry powder 0.2 18.Vanilla hot water extracted dry powder 0.2 19.Kinenhen hot water extracted dry powder 0.2 20. 21. Horaisan hot water extract dry powder 0.2 22. Preservative (paraben) suitable amount 23. Fragrance (rose water) proper amount 24. Purified water 100 residue

(Formulation Example 18) Shampoo weight% 1. Triethanolamine lauryl sulfate 5.0 2. Sodium polyoxyethylene lauryl ether sulfate 12.0 3.1,3-butylene glycol 4.0 4. Diethanolamide laurate 2.0 5. Disodium edetate 0.1 6. Sasabagin orchid 45% 1,3-butylene glycol extract 2.0 7. Dactylorhiza incarnata 45% 1,3-butylene glycol extract 2.0 8. Aozuran 45% 1,3-butylene glycol extract 2.0 10. Sakanelan 45% 1,3 -Butylene glycol extract 2.0 11.Hydroxypropyl chitosan solution 2.0 12.Muko polysaccharide solution 1.0 13.Appropriate amount of antibacterial and preservative (Photosensitizer No.101) 14.Appropriate amount of pH adjuster 15.Appropriate amount of perfume (sandalwood water) 16.Purification Water 100 and the rest

(Formulation Example 19) Rinse weight% 1. Stearyltrimethylammonium chloride 2.0 2. Cetostearyl alcohol 2.0 3. Polyoxyethylene lanolin ether 3.0 4. Propylene glycol 5.0 5. 50% Nymph butterflies 50% 1,2-butylene glycol extract 1.0 6. Butterfly 50% 1,2-butylene glycol extract 1.0 7. Onoelan 50% 1,2-butylene glycol extract 1.0 8. Futandanpopo 50% 1,3-butylene glycol extract 1.0 9. Hydroxyethyl chitosan solution 1.0 10. Trehalose solution 1.0 11. Hydrolyzed silk solution 1.0 12. Appropriate amount of antibacterial and preservative (benzalkonium chloride) 13. Appropriate amount of fragrance (lavender water) 14. Residual amount of purified water 100

(Formulation Example 20) Rinse weight% 1. Stearyl trimethylammonium chloride 2.0 2. Cetostearyl alcohol 2.0 3. Polyoxyethylene lanolin ether 3.0 4. Propylene glycol 5.0 5. Ethylene glycol 3.0 6. Extraction of 50% ethylene glycol in Hetcalane Liquid 1.0 7. Sungran 45% 1,3-butylene glycol extract 1.0 8. Sulgarane 45% 1,3-butylene glycol extract 1.0 9. Kanran 45% 1,3-butylene glycol extract 1.0 10. Kinchohen 45% 1,3-butylene glycol extract 1.0 11.50% silane 1,3-butylene glycol extract 1.0 12.Horaisan 30% ethanol extract 1.0 13.trehalose solution 1.0 14.hydrolyzed keratin solution 1.0 15.antibacterial・ Preservative (benzalkonium chloride) appropriate amount 16.Fragrance (chamomile water) appropriate amount 17.Purified water 100 residue

(Formulation Example 21) Hair liquid% by weight 1. Ethanol 29.0 2. Polyoxypropylene butyl ether phosphoric acid 10.0 3. Polyoxypropylene monobutyl ether 5.0 4. Triethanolamine 1.0 5. Yuzu hot water extract 2.0 6. 50% ethanol extract 2.0 7. Aozuran 50% ethanol extract 2.0 8. Sihylan 50% ethanol extract 2.0 9. Matsuhodo sclerotium 50% ethanol extract 1.0 10. Melissa whole plant 50% ethanol extract 1.0 11. Panax ginseng root 50% ethanol extract 1.0 12. Carpronium chloride 0.3 13. Hinokitiol 0.5 14. Keratin decomposition solution 1.0 15. Antibacterial / preservative (paraben, benzalkonium chloride) qs 16. Fragrance (senkyu water) qs 17. Purified water 100 Residue to do

(Formulation Example 22) Hair liquid weight% 1. Ethanol 29.0 2. Polyoxypropylene butyl ether phosphoric acid 10.0 3. Polyoxypropylene monobutyl ether 5.0 4. Triethanolamine 1.0 5. Trimethylene glycol 5.0 6. Himeyoran 50 % Ethanol Extract 1.0 7. Perilla 50% Ethanol Extract 1.0 8. Artemisia Plover 50% Ethanol Extract 1.0 9. Parsley Whole Plant 50% 1,3-butylene glycol Extract 0.5 10. Loquat Leaf 30% Ethanol Extract 1.0 11 Azulene 1.0 12. Antibacterial and preservative (paraben, benzalkonium chloride) proper amount 13. Perfume (touki water) proper amount 14. Purified water 100 residue

(Formulation Example 23) Hair tonic weight% 1. Ethanol 40.0 2. Ethyl oleate 1.0 3. Polyoxyethylene (40) hydrogenated castor oil 2.0 4. Saihylan hot water extract 3.0 5. Tsuchiakebi hot water extract 3.0 6. Peony skin 50% ethanol extract 3.0 7. Yuzu leaf or fruit 50% ethanol extract 3.0 8. Preservative (paraben) qs 9. Purified water 100 residue

(Formulation Example 24) Hair tonic weight% 1. l-menthol 0.2 2. ethanol 32.5 3. polyoxyethylene hydrogenated castor oil 0.5 4. propylene glycol 5.0 5. diphenhydramine hydrochloride 0.3 6. Yuzu hot water extract 2.0 7 A: Silane extract of Production Example 2 B: Sasabaginran extract of Production Example 2 C: Saihylan extract of Production Example 2 D: Hetcalane extract of Production Example 2 E: Sulgaran extract of Production Example 2 F: Production Example Shunran extract of Example 2 G: Kanran extract of Example 2 H: Goldfish extract of Example 2 I: Bosairan extract of Example 2 J: Chinese lantern extract of Example 2 K: Dactylorhiza incarnata of Example 2 Extract L: Sakuraseki extract of Production Example 2 M: Pepper extract of Production Example 2 N: Kokkiseki extract of Production Example 2 O: Hongsekku extract of Production Example 2 P: Ezo of Production Example 2 Zlan extract Q: Aos duran extract of Production Example 2 R: Rhododendron extract of Production Example 2 S: Oninoyara extract of Production Example 2 T: Sakaneran extract of Production Example 2 U: Onoelan extract of Production Example 2 V: Extract of cinnamon orchid of Preparation Example 2 W: Extract of hummingbirds of Preparation Example 2 X: Vanilla extract of Preparation Example 2 * Ax or any one of the extracts or components 5.0 8. Carboxymethylchitin solution 1.0 9. Vitamin E Derivative 0.5 10. Antibacterial and preservative (paraben) 0.1 11. Appropriate amount of fragrance (sage water) 12. Purified water 100 residue

(Formulation Example 25) Hair restorer / hair restorer% by weight 1. Ethanol 60.0 2. 50% propylene glycol extract 3.0% 3. Honsecek 50% propylene glycol extract 3. 4. 50% Shunlan 50% propylene glycol extract 3.0 5. Panax ginseng root 50% propylene glycol extract 2.0 6. Artemisia leaf or stem 50% 1,3-butylene glycol extract 1.0 7. Yarrow nut 50% 1,3-butylene glycol extract 1.0 8. Vitamin E derivative 0.5 9. Pepper tincture 0.5 10. Resorcin 0.5 0.5 Dipotassium glycyrrhizinate 0.5 12. Carboxymethyl chitin solution 0.5 13. Bovine hematin solution 0.5 14. Mucin solution 0.5 15. Amino acids (glycine, glutamine, etc.) 0.5 16. Antibacterial and preservative (paraben) 0.1 17. Appropriate amount of fragrance (rosemary water) 18. Residual water to make purified water 100

(Formulation Example 26) Hair restorer / hair restorer weight% 1. Ethanol 60.0 2. Sasabagin orchid 45% 1,3-butylene glycol extract 2.0 3. Dactylorhiza incarnata 45% 1,3-butylene glycol extract 2.0 4. Aozuran 45% 1,3-butylene glycol extract 2.0 5. Sakanelan 45% 1,3-butylene glycol extract 2.0 6. Assembly (drug) whole plant 60% ethanol extract 1.0 7. Canthari tincture 0.5 8. Pantothenic acid derivative 0.5 9. Glycyrrhizic acid 0.5 10. Resorcin 0.5 0.5 Salicylic acid 0.5 12. Hydroxyethyl chitosan solution 0.5 13. Elastin hydrolyzate 0.5 14. Antibacterial and preservative (paraben) 0.1 15. Perfume (lavender water) qs 16. Purified water 100 And the rest

(Formulation Example 27) Granule bath agent weight% 1. Sodium bicarbonate 58.0 2. Anhydrous sodium sulfate 30.0 3. Borax 2.0 4. A: silane hot water extraction powder B: sasabagin orchid hot water extraction powder C: Saihairan heat Water-extracted powder D: Hetsukaran hot-water extract powder E: Surgalane hot-water extract powder F: Shunran hot-water extract powder G: Kanlan hot-water extract powder H: Golden hen hot-water extract powder I: Hosairan hot-water extract powder J: Hakusanchidori heat Water extraction powder K: Dactylorhiza incarnata hot water extraction powder L: Sakurasekoku hot water extraction powder M: Red pepper hot water extraction powder N: Kokkisekoku hot water extraction powder O: Hongsekoku hot water extraction powder P: Ezosuzuran hot water extraction powder Q: Aozuran hot water extraction powder R: Tsuchiakebi hot water extraction powder S: Oninoyara hot water extraction powder T: Sakanelan hot water extraction powder U: Onoelan hot water extraction powder V: Chouran hot water extract powder W: Nyohouchidori hot water extract powder X: Vanilla hot water extract powder ※ A to X either one extracted powder 5.0 5. dye (ultramarine green) qs

(Formulation Example 28) Granule bath agent weight% 1. Sodium bicarbonate 58.0 2. Anhydrous sodium sulfate 30.0 3. Borax 4.0 4. Dried powder extracted with hot water 3.0 3. Dried powder extracted with hot water 3.06 .Vanilla hot water extraction dry powder 3.0 7. Oninoyaga hot water extraction dry powder 3.0 8. Sekkoku hot water extraction dry powder 2.0 9. Grapefruit winter blue 70% ethanol extraction dry powder 1.0 10. Iris leaf or root 70% ethanol extraction dry powder 1.0 11. Apple juice powder 1.0 12. Pigment (Gunjo, chromium hydroxide) Appropriate amount 13. Fragrance (grape water) Appropriate amount

(Formulation Example 29) Coating protectant 45% 1,3-butylene glycol extract, 45% 1,3-butylene glycol extract, and Aozudran 45% 1,3-butylene glycol extract on gauze or liniment cloth Liquid, Sakanelan 45% 1,3-butylene glycol extract,
Impregnated with a prescription solution containing an appropriate amount of antibiotics, anti-inflammatory, etc., to provide a protective agent for clothing attached to the wound. Alternatively, the hot water extract of the Willow tree may be directly applied locally and covered with gauze or the like.

(Test 8) Use effect test (1) Procedure The emulsion, granule bath preparation, shampoo, rinse, and hair tonic prepared in the examples were used as test articles (a), and male and female panelists (1 in total)
0). As a comparative product (b), a preparation excluding the product of the present invention was prepared in the formulation of each cosmetic composition. ) Was used under the following conditions, and the answer from the questionnaire was asked.

(2) Conditions of Use Emulsion: Immediately after washing in the morning, immediately after bathing at night, and applied to the face. 3mL each, 1 time each day Granule bath agent: Bathing bath, 30g, 1 time / day Shampoo: Use for washing hair, 10mL, 1 time / day Rinse: Use immediately after shampoo, 10mL, 1 time / day Hair Tonic: used after washing hair, 10mL, once / day

(3) Questionnaire Results The results of the questionnaire are shown in Table 2.

[0134]

According to the present invention, an antioxidant and a humectant containing at least one plant extract selected from orchids of the present invention are excellent in an active oxygen scavenging effect and an inhibitory effect on lipid peroxide production. It was confirmed that it had a moisturizing property. Also,
Cosmetic compositions containing these are effective in improving spots, wrinkles, skin color, improving dry and rough skin, and giving the skin a luster and firmness. For hair, drying, pasatsuki, split ends, It has a beautiful skin effect and an anti-aging effect, which are effective for cutting hair and imparting gloss.

[Brief description of the drawings]

BRIEF DESCRIPTION OF DRAWINGS FIG. 1 is a graph showing changes over time in skin electrical conductivity of a plant extract application site of silane, sasabagin orchid, haihailan, and hetsukaran (Example: Moisturizing property 1 of plant extract).

FIG. 2 is a graph showing a change over time in skin electrical conductivity (Example: moisturizing property 1 of plant extract) at a site where a plant extract of sulgaran, shunlan, kanran, and goldfish was applied.

[Fig. 3]
It is a figure which shows the time-dependent change of the skin electric conductivity of the za incarnata and the plant extract liquid application site of Sakuragoku (Example: Moisturizing property 1 of a plant extract).

[Fig. 4] Sec., Sec., Hon.
It is a figure which shows the time-dependent change of the electrical conductivity of the skin of the site of the application of the plant extract of Ezo lily of the valley (Example: Moisturizing property 1 of the plant extract).

[Figure 5] Aozudran, Tsuchiakebi, Oninoyagara,
It is a figure which shows the time-dependent change of the skin electric conductivity (Example: Moisturizing property 1 of a plant extract) of the plant extract application site of Sakaneran.

FIG. 6 is a graph showing changes over time in skin electrical conductivity (Example: moisturizing property 1 of a plant extract) at a site where a plant extract of an onoelan, a butterfly, a butterfly, and a vanilla are applied.

FIG. 7 is a diagram showing the results of an active oxygen elimination test of the product of the present invention.

FIG. 8 is a graph showing the results of a lipid peroxide production inhibition test of the product of the present invention.

────────────────────────────────────────────────── ───

[Procedure amendment]

[Submission date] February 22, 2001 (2001.2.2)
2)

[Procedure amendment 1]

[Document name to be amended] Statement

[Correction target item name] 0020

[Correction method] Change

[Correction contents]

The antioxidant, humectant or cosmetic composition of the present invention may further contain, if necessary, the following components and additives as long as the effects of the present invention are not impaired. The drug can be produced by selecting and using any of the agents.
% Is preferred.

──────────────────────────────────────────────────続 き Continued on the front page (51) Int.Cl. ⁷ Identification symbol FI Theme coat ゛ (Reference) A61K 7/00 A61K 7/00 U 7/06 7/06 7/075 7/075 7/08 7/08 7/42 7/42 7/50 7/50 A61P 39/06 A61P 39/06 // A61K 35/78 A61K 35/78 CF term (reference) 4C083 AA072 AA082 AA111 AA112 AA122 AB032 AB102 AB172 AB212 AB232 AB242 AB312 AB352 AB432 AB442 AC012 AC022 AC062 AC072 AC102 AC122 AC132 AC182 AC242 AC422 AC432 AC442 AC472 AC482 AC532 AC542 AC552 AC582 AC642 AC682 AC692 AC792 AC852 AD042 AD092 AD112 AD272 AD322 AD412 AD442 AD452 AD512 AD532 AD552 AD642 AD662 CC04 CC05 CC06 CC07 CC23 CC25 EE28 4C088 AB89 BA08 NA14 ZA89 ZC21

Claims (5)

[Claims] 1. One or two selected from orchids
An antioxidant comprising at least one plant extract. 2. The orchid plant is a genus of silane, genus quinrane,
A plant selected from the group consisting of a plant belonging to the genus Rhinoceros, the genus Hungran, the genus Santorini, the genus Aesculus, the genus Periwinkle, the genus Rosa, the genus Oninoyaga, the genus Sakaneran, the genus Orchis, or the genus Vanilla. Item 1. The antioxidant according to Item 1. 3. One or two selected from orchids.
A humectant comprising at least one plant extract. 4. An orchid plant comprising a genus silane, a genus orchid,
A plant selected from the group consisting of a plant belonging to the genus Rhinoceros, the genus Hungran, the genus Santorini, the genus Aesculus, the genus Periwinkle, the genus Rosa, the genus Oninoyaga, the genus Sakaneran, the genus Orchis, or the genus Vanilla. Item 4. The humectant according to Item 1. 5. A cosmetic composition containing one or more selected from the antioxidants and / or humectants according to claim 1. Description: