JP2002363088A - Elastase activity inhibitor or cosmetic composition - Google Patents

Abstract

PROBLEM TO BE SOLVED: To obtain a new and safe elastase activity inhibitor, and to prepare a cosmetic composition. SOLUTION: The elastase activity inhibitor contains one or more extracts of herbs selected from Aristolochina debilis, Pinellia ternata, Vaccinium vitis, Gentiana scabra, Cyperus rotundus, and Tribulus terrestris. The cosmetic composition contains the elastase activity inhibitor. The composition has elastase activity inhibitory action, gives luster and elasticity to skin, prevents the skin from aging, reduces wrinkles and fine wrinkles, and keeps the skin in a fresh state.

Description

DETAILED DESCRIPTION OF THE INVENTION

[0001]

BACKGROUND OF THE INVENTION 1. Field of the Invention
Crow bilberry, cowberry, gentian, namage,
The present invention relates to an application to an elastase activity inhibitor or a cosmetic composition containing one or more plant extracts selected from Tribulus terrestris.

[0002]

2. Description of the Related Art A typical change in human skin aging is wrinkles and lumps, which have become one of the major concerns for elderly people and women. However, at present, there are few effective treatments for skin wrinkles and tarmi. At present, various studies on aging are beginning to take place in an aging society.

[0003] At present, it is considered that the formation of wrinkles and lumps on human skin is caused by a decrease in the elasticity of the skin, and the factors are related to aging, drying, oxidation, and the effects of sunlight (ultraviolet rays). However, specific histological phenomena include:
Changes in extracellular matrix components such as elastin, collagen, and glycosaminoglycan in the dermis are mentioned, and it is known that changes in elastin are particularly important.

[0004] In other words, it is thought that the decrease in skin elasticity that occurs during the formation of wrinkles and tarmi involves the elastase produced and secreted from dermal fibroblasts being involved in the denaturation of the three-dimensional structure due to elastin damage. It is important to suppress the activity of elastase and to prevent denaturation of elastin, which maintains the elasticity and firmness of the skin, to prevent the formation of wrinkles and tarmi, that is, to prevent aging of the skin.

[0005]

Accordingly, the present invention suppresses the activity of elastase, restores and maintains the firmness and elasticity of the skin, thereby preventing the aging of the skin, and preventing the skin from becoming wrinkled or tarmy. It is an object of the present invention to provide an elastase activity inhibitor (an anti-aging agent) having an effect of maintaining the activity.

[0006]

In view of these circumstances, the present inventors have developed a useful plant having an elastase activity inhibitory effect as a theme of development. As a result, the present invention relates to a plant that is useful for the production of Echinacea purpurea, Raspberry shark, Cowberry, Turmeric, Hamazuge and Hamabishi. It was confirmed that one or more selected plant extracts significantly suppressed the activity of elastase. And to give the skin gloss and tension. In order to complete the present invention, the present invention provides a highly safe elastase activity inhibitor or a cosmetic composition which can maintain the skin without wrinkles and skin thinning because it prevents denaturation of elastin which is an elastic fiber. Reached.

[0007]

DETAILED DESCRIPTION OF THE INVENTION The term "Amanospermaceae (also known as horse suzukusa, mika, mokko)" used in the present invention refers to the genus Aristrochiaceae and the genus Echinacea
Plant of (Aristolochia): Eurasian sparrow (Aristolochia)
debilis Sieb.et Zucc.) peels or fruits, fruits,
Uses flowers, rhizomes and roots, but also uses A.fangchi YC Wu ex Chow et Hwang
= (A. Westlandia Hemsl.), A. heterophylla Hemsl., A. sp.
(A.kaempferi Willd.)
anchuriensis Komarov) can also be used.

"Krasubisaku (aka: Midsummer, Hange)"
Is a plant of the family Araceae (Araceae) and the genus Pinellia (Pinellia): "Pinellia ternata Breitenbach =
(P.ternata (Thunb.) Breit.) "Tuber or rhizome, corm,
Roots and stems are used, but other species of the same species (P. tri
partita Sohott) can also be used.

"Cowberry (also known as moss peach)" refers to ericaceae
(Ericaceae), a plant of the genus Vaccinium: Cowberry (V
accinium vitis-idaea L.) flowers, spikes, spikes, pericarp,
Fruit, stem, leaf, branch, branch and leaf, stem, bark, rhizome, root bark, root,
Seeds or whole plants are used, but in addition, rabbit eye blueberries (V. ashei Reade.), Highbush blueberries (V. australe Small.), Bilberries (V. myrtil)
lus L.), Kuromenoki (V.uliginosum L.), Cranberry (V. macrocarpon Ait.), Lowbush Blueberry
(V.angustifolium Ait.) Can also be used.

[0010] "Tender bean (alias: Ryutan, Ryutan)" refers to Gentianaceae, Gentian (Ge)
ntiana) Plant: Gentiana (Gentiana scabra Bunge)
Roots or rhizomes of the same species, but other species of the same species, Sasalindo (G.scabra.Bunge var.orientalis (Hara)), Tsukushi Lindow (G.scabra.Bunge var.buergeri Maxim.), Hosobarindou (G.scabra. Bunge var.stenophylla Hara) can also be used.

[0011] "Hamasuge: (alias: Hamagasuga, Kabushiko, Kobushi)" is a plant belonging to the family Cyperaceae, Cyperus, and the plant of the genus Cyperus rotundus.
L.) tubers or rhizomes, corms, roots, stems and whole plants are used.

[0012] The term "Tribulus terrestris (also known as Hamabishi, Shiturishi)" refers to Zygophyllaceae and Tribium (Trib).
ulus): The peel and fruit of Tribulus terrestris L. are used.

[0013] The extracts of Echinacea purpurea, avengers, lingonberry, euphorbia, hummus, and Tribulus terrestris used in the present invention include various parts (flowers, spikes,
Fruit, peel, fruit, ears, stem, corm, leaf, branch, foliage,
Stem, bark, rhizome, root bark, root, tuber, seed or whole plant)
Crushed and then squeezed. Alternatively, it is extracted with a solvent as it is or after pulverization.

The extraction solvent for the above-mentioned various plant extracts may be selected in consideration of the purpose and type of the product to be provided, the processing to be performed later, and the like.
Water, lower alcohols such as methanol, ethanol, propyl alcohol, isopropyl alcohol, butanol, isobutanol or water-containing lower alcohols, polyhydric alcohols such as propylene glycol, 1,3-butylene glycol, glycerin or water-containing polyhydric alcohols, acetone, acetic acid It is desirable to use one or a mixture of two or more selected from various organic solvents such as ethyl. However,
When the content of the organic solvent is not preferable due to the purpose of use, water alone may be used, or ethanol which can be easily removed after extraction may be used alone or in any mixed solution with water. It may be an extracted one.
Furthermore, it can be used in a state where each solvent extract is combined.

In addition to the above-described various plants, those obtained by hydrolysis with an acid or alkali, in addition to hydrolysis and extraction by enzymatic decomposition, can also be used.

The production method is not particularly limited, but it may be within the range of the boiling point of the solvent at normal temperature and normal pressure.
A solution, paste, gel, or powder may be obtained by decoloring and purifying. In many cases, it can be used as it is, but if necessary, further purification treatment such as deodorization and decolorization may be added as long as the effect is not affected. An activated carbon column or the like may be used, and ordinary means generally applied to the extracted substance may be arbitrarily selected. Further, an organic solvent such as ethanol, propylene glycol, 1,3-butylene glycol, or an arbitrary mixture thereof can be added to the extract after extraction. The obtained extract can be used as it is, but it can also be used as a paste or powder after concentration and drying.

[0017] The various plant extracts of the present invention can be contained in an elastase activity inhibitor and a cosmetic composition, and the content thereof is not particularly limited. Elastase activity inhibitor, the type of cosmetic composition, quality, slightly different depending on the expected degree of action,
Usually, it is 0.0001% by weight or more (hereinafter expressed as%), preferably 0.01 to 50.0% in terms of solid content in the total amount of the preparation. In the case of a bath agent, the formulation may be considered so as to be poured into 200 to 300 L of bath water so as to have the same concentration.

The elastase activity inhibitor and cosmetic composition of the present invention may be in any dosage form and form, such as capsules, powders, granules, solids, liquids, gels, air bubbles, emulsions, creams,
It can be used in the form of an ointment, a sheet or the like.

The field of application is, for example, generally applicable to various external preparations (including preparations used for animals). Specifically, ampules, capsules, pills, tablets, powders, granules, solids, 1) Pharmaceuticals, 2) Quasi-drugs, 3) Topical or systemic skin cosmetics (e.g., cosmetics) in suitable forms for use in liquids, gels, bubbles, emulsions, sheets, mist, sprays, etc. Basic cosmetics such as water, emulsions, creams, ointments, lotions, oils, and packs, facial cleansers and skin cleansers, massage agents, cleansing agents, hair removers, depilatory agents, shaving treatments, after-shave lotions, pre-shows Lotion, shaving cream,
Makeup cosmetics such as foundation, lipstick, blusher, eyeshadow, eyeliner, mascara, perfumes, nail polish, nail enamel, nail enamel remover, cataplasm,
Plasters, tapes, sheets, patches, aerosols, etc.), 4) medicinal or / and cosmetic preparations applied to the scalp / hair (eg, shampoos, rinses, hair treatments, pre-treatments) Agents, permanent solutions, hair dyes, hair styling agents, hair tonics, hair growth / hair restoration, cataplasms, plasters, tapes, sheets, patches, aerosols, etc.), 5) 6) In addition, axillary deodorants, deodorants, deodorants, antiperspirants, hygiene products, sanitary cotton, wet tissues, toothpastes, mouth fresheners, gargles and the like.

The elastase activity inhibitor and the cosmetic composition of the present invention may optionally contain, in addition to the above-mentioned essential components, the components and additives exemplified below as long as the effects of the present invention are not impaired. Can be selected and used in combination, and the content in the preparation is not particularly limited, but is usually 0.0001 to 0.0001.
50% is preferred.

(1) Various fats and oils Avocado oil, almond oil, fennel oil, perilla oil,
Olive oil, orange oil, orange luffer oil, sesame oil, cocoa butter, chamomile oil, carrot oil, cucumber oil, tallow fatty acid, kukui nut oil, safflower oil, shea butter, liquid shea fat, soybean oil, camellia oil, corn oil, rapeseed Oil, persic oil, castor oil, cottonseed oil, peanut oil, turtle oil, mink oil, egg yolk oil, palm oil, palm kernel oil, mocro, coconut oil, tallow, lard, squalene,
Squalane, pristane, hydrogenated products of these oils and fats (hardened oils, etc.) and the like.

(2) waxes Beeswax, carnauba wax, whale wax, lanolin, liquid lanolin, reduced lanolin, hard lanolin, candelilla wax,
Montan wax, shellac wax, rice wax, etc.

(3) Mineral oil Liquid paraffin, vaseline, paraffin, ozokeride, ceresin, microcrystalline wax and the like.

(4) Fatty acids Lauric acid, myristic acid, palmitic acid, stearic acid, behenic acid, oleic acid, linoleic acid, linolenic acid,
Natural fatty acids such as docosahexaenoic acid, eicosapentaenoic acid, 12-hydroxystearic acid, undecylenic acid, tall oil, and lanolin fatty acid, isononanoic acid, caproic acid, 2-ethylbutanoic acid, isopentanoic acid, 2-methylpentanoic acid, and 2-ethylhexane Synthetic fatty acids such as acids and isopentanoic acid.

(5) Alcohols Ethanol, isopiranol, lauryl alcohol,
Natural alcohols such as cetanol, stearyl alcohol, oleyl alcohol, lanolin alcohol, cholesterol, phytosterol, and phenoxyethanol;
Synthetic alcohols such as hexyldecanol, isostearyl alcohol and 2-octyldodecanol.

(6) Polyhydric alcohols Ethylene oxide, ethylene glycol, diethylene glycol, triethylene glycol, ethylene glycol monoethyl ether, ethylene glycol monobutyl ether, diethylene glycol monomethyl ether, diethylene glycol monoethyl ether, polyethylene glycol, propylene oxide, propylene glycol , Polypropylene glycol, 1,3-butylene glycol, pentyl glycol, glycerin, pentaerythritol, threitol, arabitol, xylitol, ribitol, galactitol, sorbitol, mannitol, lactitol, maltitol and the like.

(7) Esters Isopropyl myristate, isopropyl palmitate, butyl stearate, hexyl laurate, myristyl myristate, oleyl oleate, decyl oleate, octyl dodecyl myristate, hexyl decyl dimethyloctanoate, cetyl lactate, Myristyl lactate, diethyl phthalate, dibutyl phthalate, lanolin acetate, ethylene glycol monostearate, propylene glycol monostearate, propylene glycol dioleate and the like.

(8) Metal soaps Aluminum stearate, magnesium stearate, zinc stearate, calcium stearate, zinc palmitate, magnesium myristate, zinc laurate, zinc undecylenate and the like.

(9) Gum, saccharide or water-soluble polymer compound Arabic gum, benzoin gum, dammar gum, guaiac oil, Irish moss, karaya gum, tragacanth gum,
Carob gum, quinseed, agar, casein, lactose,
Fructose, sucrose or an ester thereof, trehalose or a derivative thereof, dextrin, gelatin, pectin, starch, carrageenan, carboxymethyl chitin or chitosan, hydroxyalkyl (C2-C4) to which an alkylene (C2-C4) oxide such as ethylene oxide is added. )
Chitin or chitosan, low molecular weight chitin or chitosan, chitosan salt, sulfated chitin or chitosan, phosphorylated chitin or chitosan, alginic acid or its salt, hyaluronic acid or its salt, chondroitin sulfate or its salt, heparin, ethyl cellulose, methyl cellulose, carboxymethyl cellulose , Carboxyethyl cellulose, sodium carboxyethyl cellulose, hydroxyethyl cellulose, hydroxypropyl cellulose, nitrocellulose, crystalline cellulose, polyvinyl alcohol, polyvinyl methyl ether, polyvinyl pyrrolidone, polyvinyl methacrylate, polyacrylate, polyalkylene oxide such as polyethylene oxide and polypropylene oxide Or its crosslinked polymer, carboxyvinyl polymer, polyethylene N'imin like.

(10) Surfactant Anionic surfactant (alkyl carboxylate, alkyl sulfonate, alkyl sulfate, alkyl phosphate), cationic surfactant (alkyl amine, alkyl quaternary ammonium salt) ), Amphoteric surfactant:
Carboxylic acid type amphoteric surfactant (amino type, betaine type), sulfate ester type amphoteric surfactant, sulfonic acid type amphoteric surfactant, phosphate ester type amphoteric surfactant, nonionic surfactant (ether type nonionic Surfactants, ether ester type nonionic surfactants, ester type nonionic surfactants, block polymer type nonionic surfactants, nitrogen-containing nonionic surfactants), other surfactants (natural surfactants) , Derivatives of protein hydrolysates,
Polymer surfactants, surfactants containing titanium and silicon,
Fluorocarbon surfactants).

(11) Various vitamins Vitamin A group: retinol, retinal (vitamin A
1), dehydroretinal (vitamin A2), carotene, lycopene (provitamin A), vitamin B group: thiamine hydrochloride, thiamine sulfate (vitamin B1), riboflavin (vitamin B2), pyridoxine (vitamin B)
6), cyanocobalamin (vitamin B12), folic acids,
Nicotinic acids, pantothenic acids, biotins, choline,
Inositols, vitamin C group: vitamin C acid or its derivative, vitamin D group: ergocalciferol (vitamin D2), cholecalciferol (vitamin D3),
Dihydrotaxerol, vitamin E group: vitamin E or its derivatives, ubiquinones, vitamin K group: phytonadione (vitamin K1), menaquinone (vitamin K
2), menadione (vitamin K3), menadiol (vitamin K4), other essential fatty acids (vitamin F), carnitine, ferulic acid, γ-oryzanol, orotic acid, vitamin Ps (rutin, eriocitrin, hesperidin), vitamin U etc.

(12) Various amino acids: valine, leucine, isoleucine, threonine, methionine, phenylalanine, tryptophan, lysine, glycine, alanine, asparagine, glutamine, serine, cysteine, cystine, tyrosine, proline, hydroxyproline, aspartic acid, glutamic acid , Hydroxylysine, arginine, ornithine, histidine, etc., and their sulfates, phosphates, nitrates, citrates,
Or amino acid derivatives such as pyrrolidone carboxylic acid.

(13) Various additives derived from plant or animal raw materials These are processed in a conventional manner according to the type and form of the product to be added (for example, pulverization, milling, washing, hydrolysis, Fermentation, purification, squeezing, extraction, fractionation, filtration, drying, pulverization, granulation, dissolution, sterilization, pH adjustment, deodorization, decolorization, etc. You can choose to serve.

The solvent used for the extraction may be selected in consideration of the purpose and type of the product to be provided, or the processing to be performed later, but usually, water, methanol, ethanol, propyl alcohol, isopropyl alcohol, etc. Select from alcohols, lower alcohols such as butanol and isobutanol or water-containing lower alcohols, polyhydric alcohols such as propylene glycol, 1,3-butylene glycol and glycerin or water-containing polyhydric alcohols, acetone and various organic solvents such as ethyl acetate. It is desirable to use one or a mixture of two or more of these. However, when the content of the organic solvent is not preferable depending on the application, only water may be used, or ethanol which is easily removed after extraction may be used, and may be used alone or in an arbitrary mixed solution with water, Exploited extract may be used.

In addition, additives derived from plant or animal raw materials are
When applied to systemic or topical external preparations and cosmetics, including protection of skin and hair, moisturizing, improvement of feel and texture,
Giving flexibility, relieving irritation, relieving stress by fragrance, activating cells (preventing cell aging), suppressing inflammation, improving skin and hair quality, preventing and improving rough skin, hair growth, hair growth, hair loss prevention, gloss Application, cleaning effect, alleviation of fatigue, promotion of blood flow,
In addition to cosmetic effects such as warm bath effect, fragrance, deodorant, thickening,
Antiseptic and buffering effects can also be expected.

Specific plants (crude drugs) as raw materials include
For example, almonds (herring peach), eyes (blue leaves), blue moss
(Seifu Fuji), Aoki (Aoki), Aogiri or Kenasia Ogiri
(Otogi), Aotsu-la-fuji (Kibo), Aotenma, Acacia, Akasho (Akasho), Akasuguri (fruit), Red clover, Red grape, Akaminoki (Logwood), Akamegawiwa (Red bud), Akaminokane or Akane Akane or Akane (Akane) Grass root), red pheasant or pheasant (land yellow),
Agi (Awei), Aki larch, Akinire (Lolyu bark), Aguay Guacu, Aguahe (Wolverine palm), Akebi
(Kidori), Asa (Jin Asako), Malva Asagao or Asagao
(Toshiko), hydrangea (hydrangea), ashitaba (morning leaves), azuki (red azuki bean), asunaro, acerola, asenyaku (asenyaku), acira (shokuyoukanna), anise, abiu, abiulana, rape and abemaki `` fruit '' ,Avocado,
Ama, Amacha (Amacha), Amachaworu, Amadokoro (Jade bamboo), Amana (Kojingi), Amaranthus (Hyuyu, Hagaito, Himogeito, Senninkok, Sugimorigeito,
Hosoagaitou, Aoagetoi, Haribiyu, Aosuzuran, Amaranthus hippochondriax), Amigasa lily or Bimo (shellfish), Aristolomelia (Urizusensen), Arcana (Alcanna), Algarrobo (Cave), Altea, Arnica, Alpinia or Katsumadai
(Sorghum), aloe (lux), aloe vera, angelica, apricot or hon apricot (almond jelly), ansokko (benzoic acid), yellow sapote, scutellaria (biliary head), epimedium or primrose (inyokaku), rush
(Wicked grass), Knotweed (Tiger root), Yew (1st), Strawberry,
Figs (fructose `` fruits and leaves ''), Ichihatsu (primary), ichibi (winter aoiko), Ichiyakusou (one medicinal herb), ginkgo (ginko `` seed and leaves ''), Itohimehagi (enshi), carob, and locust bean (Telexa) , Inubeil (Honagainubeil), Rice `` seed, seed coat '', Inondo `` seed '', Ibuki-kusou, nettle, ylang-ylang, iwa-tobacco
Iwahiba or iwamatsu (makikashiwa), oolong tea, fennel
(Fenka), Wheat (Chibusanoki), Ukiyagara (Sanryong), Uguisukagura `` fruit '', Himeukikyo, turmeric (Utsukin), Duckweed (buoying), Usubasaishin or Keirinsaishin or Oushusaishin (spicy), Usveniaoi , Foxglove, moth orchid, moray
(Summer hay), Udo or Shishiudo (Qanggai, Independent, Tang Dungho), Unyadegato (Unkaria, Cat's claw), Uba tea, Ume (Omeme `` seed, flesh ''), Vladimir, Uwaurushi
(Kusaco peach), Unshu mandarin orange (Chen skin), Unboku,
Estragon, Ezokogi (Ezo Goka), Ezo Lily of the valley,
Echinashi (Hoshibamurasakibarengiku), Enishida, Enokitake (Enotake), Ebisugusa or Cassia Tora (Keyoshiko), Elcampre, Elderberry `` fruit '', Elemi, Elingii or Pre Lotus Elinge, Ende
(Gossip, Sophora rice), ogre or Kibana-ohgi (Astragalus), Narco lily or Kagi Kurumabanaruko lily (Yoshisei), Ohhisasanoyuki or Sasanoyuki, Oren (Yellow), Ogata Hawken, Ookarasuri (Karokon), Ooguruma (Civil) , Ootsuji rafuji (self-defense), Psyllium (vegetative child, vegetative grass), psyllium thistle (Keju sashimi, bald man), eucalyptus (Haruko), pygmy cactus, pygmy pygmy or ophylla (white jitsu), pygmy pygmy (banaba), Beetle shabushi `` fruit '', giant grasshopper (grain sperm), giant caterpillar, hawthorn hawthorn or hawthorn (yamako), barley
(Barley), oka, okazeri (snake bed), okra `` fruit '', oguruma (turnover), okururihigotai (yushu sashimi, indigo head),
Panax ginseng or Caribbean ginseng (carrot), Hypericum perforatum or Hypericum perforatum or St. John's wort (brother's cut grass), Officinalis (intermittent), Onamimi (blue ears),
Onigurumi, Onidokoro or Tokoro or Nagadokoro (Hikai), Oninoyagara (Tianma), Oniyuri or Sasasayuri or Hakatayuri (Yuri), Onoeran, Ononis, Halibut
(Hihayu), Ominaeshi (losing sauce), Oyuco, Dutch mustard (Watercress), Dutch jelly, Dutch biyu, Dutch honeywort, olive "fruit, seed, leaf", oregano, orange "fruit, pericarp," Yellow), cacao "fruit, peel, seeds", kaki (persimmon "leaf"), kagikazura
(Hooks of Choto), Persimmon or Kantriso (Rensenso), Kakiran, Gaku hydrangea, Cassia, Kasinaki (Kozou `` fruit ''), Kajutsu (Shazajutsu), Kashiwa (Yanagi, Yuzuha), Kascarilla, Kascara sagrada , Gypsophila, gypsophila, kanikusa (kinsato), kaniwa, carnation, valerian (valerian root), hippopotamus, birch or weeping birch (white birch),
Gerbera, Pumpkin, Capoknoki `` seed '', Kahoku Sansho (shopper), Gama (bamboo), Chamomile or Roman chamomile, Kamiyatsude (weed), Kamkamu (duckling), Color, Karakakeman, Ragusuri or Shinakorasuri
(Our melon), oats, guarana `` seed, '' Kalahoo (thick), Karaya, Galyu, Karin (mouse), Garcinia,
Kawamidori, Kawara Psycho (Koryo greens, white-leaved grass), Kawazashia, Kawaratake, Kawaranadeshiko (stone bamboo) or Ezokawaranadeshiko (Qumugi, Quumiko), Carrot ginseng (Blue potato), Kawamuragi (Blue potato), Kansui (sweet) , Licorice (licorice), canthala, candelilla, canto, canna,
Perilla, Raspberry (Ezo strawberry, Dutch strawberry, Shrimp strawberry, Nawashiroi strawberry, Maple strawberry, European strawberry), Kiwi `` Fruits, leaves '', Kikarasuuri (Ururone), Kikyo (Kikyo, Kikyo root), Kiku (Chrysanthemum, Chrysanthemum, Narcissus) ), Kikutaniki, Catalpa (Azumitsu), Rumex (Yotei), Pheasant (Kikomi), Kizuta, Kidachi aloe, Kidachiha, Kinna, Kinoki (Shincona, Akakinoki), Quinoa (Quinoa), Kihada (Huangbai),
Gymnema Sylvesta, Kimmenkaku, Cabbage, Cabbage "Immature Fruit", Caraway, Cucumber, Gyoryu
(Nishikawayanagi, Ichiyanagi), Kiraja Saponaria, Kiraya, Kiranso (Kinen Koso), Kumquat `` fruit '', Ginkai,
Kimbusen, betel, quince cypress (Senaku-kusa), quinran, ginkgo, kinryohen, guapeba vermelha, guava `` fruit '', guayule, quelux infectria (gallicate), cucuinuts, kugenumaran, cucumber (cucumber, cucumber, cucumber leaf, ground) Bone bark), Cedar grass (Tenmen Fuyu), Kuzu (Kakkon), Camphor tree, Gooseberry `` fruit '', Xining ginseng (Hot flower), Cutiti river,
Gardenia (Gardenia), Kunugi (Bokusou), Kupuas, Kubeba, Kumazasa, Kumatsuzura (Erythrophila), Clara (Bitterfruit), Chestnut `` seed, fruit, astringent skin '', Curculigo latifolia `` Fruit '', Grapefruit `` Fruit / leaf '', Buckthorn, black squirrel (rescue rescue), turtle bamboo sword or kurobana skull or skull (extended life grass), cloves
(Cinch, cinch), Gumbai nazuna (Sekimei, Sekimeishi), Kaigai (Ikutake, Ikutakeho), Keito (Rooster corolla, Chicken cop), Gekkavidin, Geckage (laurel), Kenashi Sartoriibara (Tokubukuryo, Yamakiko), Gentian, Gennoshoko (Old Tokusa), Kemponashi (Kigushi), Koukisekikoku, Kishumitsukan (Koji, Tachibana, Obenimikan, Fukuromikan, Sagamikouji, Ponkan, Santara
(Tachibana Skin)), Koshinbara (Monthly Flower), Kosui Minka, Kozo (Fruit), Kocha (Tea), Kouhone (Rawbone), Kouhon (Straw Book, Karawara Book), Koulyan, Koryokyo
(Kora Kyo), Cilantro `` fruit '', Kouen (Huanglian),
Koganebana (yellow gon), coconut `` fruit '', goshuyu (goshuyu), goshoichigo (covered bunko), pepper (pepper), cosmos, copaiba balsam, coffee `` seed, leaves '', kobushi or magnolia (spicy), burdock (burdock) , Burdock), coconut wool, sesame (sesame), sesame seeds (ginseng), garnish (gomiko), Sanekazura or Binankazura or Matsubusa, wheat (wheat), rice or rice bran "red bran, white bran", rice oil, cola acuminata “Seeds”, Cola Bella “Seeds”, Colony Lya, Fenugreek “Fruits”, Colombo, Consulango,
Kombu, Konjac, Comfrey (fin-bared grass), sisal
(Sisal Asa), Saihairan, Sakaneran (Ezosakaneran), Sakisima button or Sina button or Sesame ninsou (weird sac), Sakura (Oshimazakura,
Yamazakura, Oyamazakura, Edhigashi, Mamezakura, Miyamazakura, Someiyoshino, Takanezakura, Kasumizakura, Kohigan, Satozakura, Kanzakura
Flowers, fruits, bark (cherry bark) ''), cherries, pomegranates, sasa, sasabagin orchids, sasanqua, sajimodaka (sawaka),
Sweet potato, sugar cane, sugar beet, jujube jujube (acid jujube), saffron (safflower, west safflower), sapodilla,
Sapotea marillo, pomelo `` fruit '', saponso, salmon berry `` fruit '', sarashinasho (masuma), saransitou (sand indigo stalk), salvia (sage), sawagyoukyo (snowfish), sawagurumi (snow walnut), sankaku cactus, Sangre degrad (croton), Sansuiyousou, Sansin ginseng (seven carrots), Sanshuyu (sanshuyu), sansho (sanshoyu), sanzukon (Yamazone), shea (carite), cyanoki `` fruit '', shiitake ( Shiitake mushrooms), Shion (Shizono), Dikitaris, Sikunshi (Kimiko), Perilla or Aodiso or Chirimenzo or Catamejiso (Shiyo leaf, Shiso), Rosewood, Shinanoki, Shinanohoonoki, Japanese cinnamon (Linus edulis), Shimejiji
(Hinshimeji, Shakashimeji, Hatakeshimeji, Oshiroishimeji, Bunashimeji, Honjimeshi, Shirotamogitake),
Shimokure (Spirit), Spiraea, Potato, Peony (Shakuyaku), Shajin (Shasan), Jasmine (Matsurika), Janohige (Motomon winter), Scutellaria paniculata, Skushamitsu (sand sand, shrinking sand), Juzudama, Shiro Fruits, Shunlan, Ginger (Ginger), Jouzan Hydrangea (Tsuneyama), Shobu (Iris, Iris root), Shozuku (Fruits), Shirakashi (Seeds), Silane (Byanchu), Shirogoshi Butterflies (Seeds), White clover (Clover), White adzuki bean (chicken bone grass), white bean iris (small iris), white beetle `` flower '', white nananthen (minamiminami), cinchona sacyl bra, ginkgo biloba (mizuka, mizukahana, kenchohana),
Cinnamon, Cinnammom Cassia (cinnamon bark), watermelon
(Watermelon), honeysuckle (gold and silver flowers, Shinobi winter), sorrel (acid pattern), swimberry `` fruit '', star apple, stevia, strawberry `` fruit '', tin psycho (Xu Cho Lord), sugina (question thorn), suberhide (horse ken, Kento), plum "fruit", sulgaran (orange), Pinus sylvestris "cones", larch, vegetative leaves, horned walnuts, hawthorn, eucalypt, dandelion, horse chestnut (malonie), and pear berries ”
(Elder), Atlantic shrew (Juniper, Juniper), Achillea millefolium (Mirfoil), Atlantic rose, Atlantic anemone butterfly, Atlantic mistletoe, Atlantic mint or Atlantic mint, Horseradish, Sekisho
(Iris), Sec. Celery, Senkyu (River Kyu), Senshinren (Senshinren), Sendan, Sennin Cactus, Senna `` Fruits, Leaves '', Senninsou (Large Tate), Senburi (Drugs), Senboku, Soka
(Grass), Elephant Chestnut, Soshinwabai, Buckwheat `` seed '', Soybean Potato, Rhubarb (Ohaku), Radish, Soybean, Daidai (Orange skin, Kikomi), Takasagouri Rigogotai (Southeast Aizashi), Takasaburo (Dried Lotus), Takatodai (Daigei), Takawarabi (Inu), Dark Sweet Cherry `` Fruit '', Tachiaoi, Tachijakosou (Thyme, Momoka), Tachidokoro (Hikai), Tachiyanagi, Tamarind `` seed '', Onion, Tamashiba (Spirit), Taranoki Fruits, leaves, root bark ",
Tarayou (Oba Fuyu, Ichiyocha, Kuchocha, Malancha), Dahlia
(Tengiku button), Talwi, Tanshiniwa, Tanjin
(Dan ginseng), Dandelion (Bakakohide) or White dandelion or Moko dandelion, Dammar, Cherry `` fruit '', Chigaya `` fruit, root, bud '', Chikusetsu carrot (bamboo ginseng), chicory, chancapiedra (Kidachiko Mikansou), tulip, Choconostay, Korean Radish (Rhuanghuang), Korean Radish (Wuyi), Korean Artemisia (Aiba), Choreimaitake (Irei), Chorogi, Tsukimiso, Tsukusushikaneran, Tsukuritake (mushroom), Tsuchiakebi, camellia, camellia, clover Lacquer mother grass), asiatic dayflower (duckling primrose), vine adzuki (red azuki bean), tsurutsuchiakebi, tsuldokudami (what a crow), tsuruna (ban apricot), tsurin carrot (four leaf ginseng),
Tsuwabuki, Deiko, Teuchigurumi, Duberry `` Fruit '', Tengusa, Tencha (Tencha), Tendaiyaku (Cowflower), Touga (Fruit gourd), Touoka Kazura, Pepper (Pan pepper), Touki (Toki), Tokinsenka (Marigold) ), Cornflower (river cut), corn or corn hair (nanban hair), horned rice mochi (female child), tokusa (wood pirates), dokudami (jujutsu), konkon (spit root), toshishi or beetle or beetle or pear or eucommia (tochu) "Bark, leaves,
Roots), ash (qin peel), tomato, tragacanth, triacanthus `` seed '', eustoma, tormentilla, dronoki, troloioi, tongue bean, Niseria berry `` fruit '', potato or yam (herbal medicine), squid
(Butcher Bloom), Naginata Kouju, Nazuna, Rape, Natsume bean or Hatehaki (sword bean), Natsumikan, Jujube (daijutsu), Naniwaibara (Kanakurako), Navena (intermittent), Nameko, Peanut (peanut), Nanten (Nanten) Fruit), Nanban karamushi (ramie), scented violet, nigaki (bitter tree), sagebrush (bitter berry), nutmeg, kei or nikkei or ceylon nikkei or yabnikkei (cinnamon bark) or keishi (keishi),
Grey-eared plover, Chinese chive (Nirako), elderberry (bone-bearing tree `` fruit, flower, stem, leaf ''), garlic (garlic), nulde (quintuple), leek, nemuki or nebu or nebi or nemlinoki or zigokubana (health), noami ( Daiji), Noibara (real fruit), Nori Kazura (Ryoshohana), Nogateto, Yarrow, Nodake (Maehu), Nobara, Nomomo, Pineapple `` fruit '', Hibiscus (Bussouge, Furinbussouge, Roselle), Hauchiwa, Pau Dosse, Hakamau Lab (Bone Crushing), Hakuka Yumato, Hakusanchidori, Hakusen (ringworm skin), Huckleberry `` Fruit '', Hakobe (proliferate), Hazelnut (Haruko), Hashiridekoro (Roto Root), Basil, Lotus (Lotus, Lotus, Lotus), Parsley (Netherland jelly), naked mussel, batata, bee or medake (bamboo-boiled), patchouli, mint (lightly loaded, lightly loaded leaves), adlay (yokunin), Hanasuge (chimbo), banana, honey mint, vanilla bins, papaya, silkworm (rat), pahalobobo, hub `` whole plant, stem, leaf '', paprika, hakimakiran, hamagou, or honeysuckle (mothworm), hamanas (maikai) Flowers), Hamabofu (beach storm), Hamamelis, palm, rose (rose),
Balata, Balata rubber tree, Agaritake (Haratake, White agaricus, Usukimori nokasa), Haran, Pariurus (Prunus avium), Parietaria, Harkanran, Balsamina (Tsurureishi, Nigaruri), Harunire
(Yu bark, Yu white bark, Yuba), Barbasco, Handaikai (Moutaikai), Breadfruit, Hiougi (Shadow), Lycopodium carrot (Party), Pecan nut, Giganbana (Shirubin, Jinjushahana), Higulmadaria, Higotai, Hishi (Hishimi), Pistachio, Beet, Aedes (Stone reed), Aedes aegypti, Daisies (Daisy), Aesculus chinensis (Cow knee), Hinata bulbul, Hinoki, Hiba, Castor, Sunflower, Bell pepper, Himeuzu (Aoi) , Himegama (incense blossom), Himematsutake (Kawariharatake, Hiromatsutake), Himemyouran, Pimenta "fruit", juniper, beakyukyu, hiyu "fruit", belowudo oyster, hirohakinagusa (bakuinokina), loquat "fruit, leaf, stem", betel wax (Large clothes skin, betel nut), Pu'er tea, Sperm squash (southern rattan), Butterfly, Butterbur dandelion (Winter flower, Winter leaf), Fujibakama (Orchid grass), Fuji bean (Tanboshi), Fujimodoki (Chautia japonica), grape `` fruit, pericarp, seeds, leaves '', beech, sycamore (caterpillar), Brazilian liquorice, Brazilian carrot, black currant `` fruit '', blackberry, blanin ,
Plum `` fruit '', flucellaria, prune, floral blanka, blonde psyllium, bundo (green bean), hazelnut, luffa, hetsukaran, safflower (safflower), henneken, belladonna, berry `` fruit '', Persair, Perbianberg, Perezchia grandifolia, Bencap or duckweed (Keiten), boysenberry `` fruit '', duckweed or elderweed or nendaw or crested kokia (skin), spinach, daffodils
Acute offspring, osteophytes), Potteria sapota, Potteria
Lucuma, spinach, boufu (windbreak), spinach, physalis (Torone), honoki (Japanese thick and plain), bokeh (gourd),
Hosoba Aburagiku (Boyoku), Hosoba Ogura, Hosovanaokera (Aojutsu), Hosobanokirinsou (Kageten Sanshichi), Hosobabarengiku, Bodaiju (Bodaiki), Button (Peony `` flower,
`` Leaves, stems, bark ''), buttonpi (peony bark), hops, jojoba, borage (ruriticha), bordeaux, white berry `` fruit '', hon-oniku (meat ゅ ゅ, large art), hon-sekkoku
(Iron bark stone, sparrow mountain stone mascara), maizel tennanshaw (tennanboshi), maitake (maitake), ephedra (mao), maca, macadamia nut, margaret (mokushungiku), macri (seaman grass), maguwa (mulberry white) (Bark, bark, leaves)), Magnolia splengheri, Masaranpouba, Masaranzuba do Ceara, Masheira de Boi, Masahua (Tamanouzenhallen, Cucumber noodles), Matatabi (Mokuten Tate), Matsukasa, pine leaves, `` Bark, roots '', Matta Olho, Matsuhodo (Bukuryo), Matico (Cordoncillo), Mayorum (Hanamint), Malvanojadine (Difficult), Mulberry `` Fruit '', Quince, Malein (Beloudomouzuica), Mango, Mangosteen, Mansana (Andeska beetle), Mansu walnut, Mandarin `` fruit '',
Mannentake (Lingzhi), Pheasant (Kikomi `` fruits ''), Mishimasaiko (Saiko), Mizuobako or Mizuasagao (Ryugoshi),
Mizokokushi (half-edge lotus), Mihohagi (Chisatsuna), Mycian willow or Japanese willow (Henryoku), Mitsugashiwa, Mitsuba, Midorisapote, Midorihakka, Mimosa, Miyoka, Miracle fruit `` fruit '', Myrrh, Mirobaran, Mugiwaragiku, Mukuge (Mokuge) , Mukunoki, Mukuroji (prolonged skin), Munya, Purple (purple root), Purple or purple
(Purple beads), purple corn, purple purple (Kunming chicken blood wisteria), megakanza opuntica, red seaweed (mother grass), red seaweed, melaleuca, melissa, melilot,
Melon `` fruit '', sagebrush, moso bamboo, moku giraffe, moje (pepper blossom), ilex, peach blossom, peach (peach `` leaves, seeds, flowers, fruits ''), bean sprouts, morello cherry `` fruit '', moroheiya (burlap), Yakawamurasakiimo, yakuchi (masuchi), cornflower (cornflower),
Cornflower, yacon, yashabushi (arrow wheel) or himeyashabushi or giant yashabushi `` fruit, peel, kaho '', yachiyanagi, yatsude (octagonal plate), mistletoe (willow parasitism), willow (kawayanagi, tachiyanagi, weeping willow,
Red Willow, Pussy Willow, Pussy Willow, Kinuyanagi, Kolyanagi, Unryuyanagi, Miyayamayanagi, Palm, Yamanagi, Obayanayanagi, Tairikkinyanagi,
(Sweaty willows and stalks), willow litter `` leaves and stems '', yabugarashi, yabukouji (purple gold beef), yabu tobacco (crane squirrel, tenna sperm), pokeweed (commercial land), yamahanoki (yamaharu), yamamomo (yumemei), yamamogi, Eucalyptus, Saxifraga (tiger eargrass), Yucca or flevifolia, Yuzu `` fruit '', lily, yorogusa, mugwort (Aiba), ligan (Rainuma), lime `` fruit '', rye, lacanca `` fruit '', raspberry `` leaf, fruit '', Latania (Crameria), Rakkyo or shallots (scallop), lavender, longan (longan meat), agave (Aono agave, fukurin agave), ryocha (green tea), apple `` fruit,
Seeds, leaves, roots ”, lubas or suavisimus, sweet potato thistle (Urajirohigotai, Xinjiang indigo head), reishi
(Lichi, lichi nucleus), lettuce (chisha), red currant `` fruit '', red pitaya, lemon `` fruit '', lemongrass, forsythia or Chinese forsythia (serial forsythia), astragalus, waxy bean, wax palm, rocon (reed, Rone),
Loganberry "Fruit", Rosemary (Mannenrow), Rosehip (Nobara), Wasabi, Cottonweed
(Ming Monka), Waremoko (Jiyu) and the like.

Examples of the seaweeds include seaweeds [green algae: Chlorella vulgaris, Chlorella pyrenoidosa, Chlorella ellipsoidia, Aonori (Usubaonori, Susiaonori, Hiraaonori, Bowaoonori, Hosoedaoonori), Anaaousa algae [Aosa] Kinds: Kombu (Macambu, Rishikonbu, Hosomekombu, Mitsuikonbu), Wakame, Hirome, Ao-Wakame, Giant kelp (Macrostistis pilifera, Macrocystis integrifolia, Neocitys luetokeana), Hijiki, Hibamata, Umiuchiwa, Usubaumiuchiwa Klebanoumi prickly pear, Akabumi prickly pear, Konau prickly pear, Okina prickly pear, Usuki prickly pear, Echinoki prickly pear], seaweed [red algae: Hijirimen, maxa (Tengusa), hirakusa, oniku , Obakusa, Kataobakusa,
Yatabegusa, Yuikiri, Shimatengusa, Tosakanori, Togekirinsai, Akumasakirinsai, Kirinsai, Junyashinkirinsai, Tsunomata, Obatsunomata, Tochaka (Yahatsutsunomata), Ezotsunomata, Togetsunomata, Hirakotonota, Kotojita
Jareus Banori, Kagius Banori, Siusius Banori, Hyus Banori, Akamomininori] and the like.

Other algae, for example, green algae (Chlamydomonas: Chlamydomonas, Akayukimo, Dunaliella: Dunaliella, Chlorococcus: Chlorococcus, Kwanomimo: Kwanomimo, Volvox: Ohikawawari, Volvox, Palmera, Yotsumemo, Spirogyra: Hizaori, Spirogyra, Tulsimidro, Hibimidro: Hibimidoro, Aosa: Anaoasa, Amiosa, Nagaosa, Kawanori: Kawanori,
Genus Fricciella, genus genus: medusa, asiaticum gutta, kawashiogusa, marimo, baronia: tamagobaronia, tamabaronia, tamagata: tamagatamo, iwata: husaiwata, surichogita, heraiwata, kurokita, kurokita, kurokita Sakibuchimil, Nagamir, Hiramil, and Casanori:
Casanoli, Juzumo
Species of the genus Mizudzumo, Genus Genus, Genus Colecaetus, Genus genus Tsutsumo, Artemisia spp .: Artemisia spp.

Cyanobacteria (Genus L .: L., L., L., L .: L., mushrooms,
(Hassay, genus genus, genus racenmo (spirulina): spirulina, genus trichodesmium (aiakacio), etc.).

Brown algae (Piraella spp .: Piraella spp., Spirogyra spp .: Namiami sp., Isogrape spp .: Isogrape,
Genus Isogawara: Isogawara, Kuroshira Genus: Gunsenkurogashira, Kashirazaki Genus: Kashirazaki, Muchimo Genus: Muchimo, Hiramutimo, Kebelligsa, Amidixa Genus: Amidigsa, Sakibiroamiji, Sanadagusa: Sanadagusa, Fukurinamiji, Common Genus Artemisia spp.
Genus genus: genus pine, genus genus: genus genus: genus genus, genus okinawa, genus okinawazuku, genus phlebosum, genus phlebosum, genus phlebosum: genus futomozuku, genus genus moss: genus genus: genus kuromo, genus moss, genus genus Ishige, Irolo, Icmegasa: Icmegasa, Keyari: Keyari, Umibos: Umibos, Urushigusa: Urushigusa,
Betula serrata, Tobacco moss, Laminaria spp. Genus Kagomenori: Kagomenori, Muraridori: Murachidori, Shakuganusa: Shakuganusa,
Genus Genus: Genus Genus, Genus Genus: Genus Genus: Genus Genus, Genus Kayamonori, Genus Genus: Genus Genus: Genus Filiformis, Genus Turmo: Genus Tsurumo, Genus Anana: Genus Anastasia, Genus Suzume: Genus Musicum, Genus Missiscoma, Genus L. , Oni-kombu, Gohei-kombu, Naga-kombu, Pea-kombu, Ochimitsu-kombu, Toro-kombu genus: Toro-kombu, Antokume genus: Antokume, Kajime genus: Kajime, Tsuruarame, Kurome, Kikuishicombu genus: Kikuishikombu, Nejirekombu: Nekorecome genus, Kuroshimae : Nekoshikonbu,
Alame: Alame, Ainuwakame: Ainuwakame, Chigaiso, Oniwakameezoishige: Ezoishige, Yabanemoku: Yanemoku, Rapamoku: Rapamoku, Jiromoku: Uganomok, Jiromoku, Hiemomoku, Hokumoku, Tamamomoku, Tamamomoku Akamoku, Shidamoku, Hondawara, Nejimoku, Narasamo, Mametarawara, Tatsukuri, Yasumatamoku, Umitrano, Oobamoku, Fushizushimoku, Hahakimoku, Togemoku, Jolemoku, Saw-moku, Obanoki-mimoku, Genus genus:
Bulumimo, genus cynomolgus: cynomolgus etc.).

Red algae (Russula genus: Rush genus, Funorinoshiki, Amanori genus: Asakusanori, Susabinori,
Genus Upirinori, Onimanori, Tasa, Filitasa, Benitasa, Rhodocorton: Milnoveni, Akebonomozuku: Akebonomozuku, Konahada: Haikonahada, Yogorekonahada, Aokonahada, Sea Species: Acer genus, Acer genus : Larch, Fusanori: Fusanori, Nisefusanori: Nisefusanori,
Sodegarami: Sodegarami, rattles: rattle, rattle rattle, hirohatamatamaki genus: hirohatamaitadaki, tamamaidaki genus: tamaitadaki, kagikenori genus: kaginori, kakenenori, tengusa: himetenugosa, haitenugosa, haitenugosa, haitenugusaugou, haitenuganugou, haitenuganugou, haitenugusaugou Genus: hibiroudo, himebiroudo,
Genus Isommedogi: Genus Isomomedo, Genus genus: Genus medusa, Ryumonsou: Ryumonsou, Hera Ryumon, Nisekarekususa: Genus Nisekaregusa, Okitsubara: Obaokitsubara, Akaba: Akaba, Malvaacaba, Naminohana genus
Naminohana, coral genus: rattle, mushroom, shiogosagoromo, iwanokawa: ezukiiwanokawa, kainokawa: kainokawa, kaninote: kaninote, coral genus: coral, coral, mosquito mosquito , Tambanori, slippery,
Fudarak, Malbahudarak, Isonohana: Nuracusa,
Cranouraxa, Stinging skull, Hunting genus: Hunting ibis, Hunting genus: Hunting sword, Hunting genus: Chabo kintoki, Hunting ibis, Matsunori, Komenori, Tosakamatsu, Aedes pine, Fushikintoki, Tsunomukade, Nagakinotoki, Scutellariae, Osmanthus Nagaobabane: Nagaobane,
Genus Funori: Hanafunori, Fukurofunori, Makunori, Kalexigusa: Kalexigusa, Sasamodoki: Hosobanotosakamaki, Hirohanokasakamuki, Yatsudegatatasakamoki, Kurosakamaki, Nezashinosakamukado, Yukasakanookado Modoki,
Genus genus, genus genus: quinohada, genus esculenta: esoteka, tsukasanori genus: enashikarimenia, ootsukasanori, hanagatakarimenija, honooo genus: honoo, genus genus: lyca genus, genus genus, genus nikonobenigo Susqueke Beni, Okamuragusa:
Yamadakusa, Mirin genus: Mirin, Hosobamilin, Tosakanori genus: Kikutosaka, Ezonameshi: Ezonameshi, Isomokka genus: Isomocca, Yukari genus: Yukari, Hosoyukari, Ibaranori genus: Ibaranori, Saidaibara, Tachiibara, Kagiibanodan, Kijinotho genus Isanthus, Atsubanori: Atsubanori,
Ogonori: Ogonori, Tsurusilamo, Shiramo, Ogogonori, Mizookonori, Kabanori, Beniogonori, Fucresinori, Murasakikabanori, Shinkaikabanori, Togekabanori, Kataogonori, Ryukyuogonori, Ryokyuogonori, Ryokyuogonori, Ryokyuogonori, Ryokyuogonori , Genus Amanita: Hachijoenaga, Fushikenori genus: Fushikenori, Namiiwatake genus: Namiiwatake, scorpion genus: Scorpion genus, Occidental genus: Okutsunori, Saimi genus: Itanigusa, Simi, Harigane, Lotus genus:
Lotus lotus, genus genus: squid
Nobonori, Black Snapper: Black Snapper, Red Snapper: Red Snapper, Hishbukuro: Hishbukuro, Madaragusa: Togemadara, Echimadara, Taoyagousou: Genus Ottawa, Scrophularia , Hirata goat: Hirata goat, Darus: Darus, Masagoshibari, Anadals, Uebagsa: Uebagsa, Benifukuronori: Benifukuronori, Fushinagi: Fushitsunagi, Himefushinagi,
Species of the genus Hirohafushi, Snapdragon
Egonori, Futogigis, Saeda: Saeda, Chrysanthemum Genus: Chrysanthemum, Konohanori Family: Habutaenori, Konohanori, Suzushironori, Usbeni: Usveni, Hasuginu: Hasuginu, Nagakonohanori: Nagakosugino, Genus: suginanu Yaleusbanori, Sujiusbanori, Hyusbanori, Usubanorimodoki genus: Usubanorimodoki, Ayanishiki: Ayanishiki, Ayaginu:
Ayaginu, Dassia genus: Enashidazia, Simadadia genus: Isohagi, Shimadada, Dazimodoki genus: Daziomomodoki, Itogusa genus: Moletogusa, Futoigusa, Macri genus: Macri, Yanaginori genus: Hanayanagi, Yuna, Sanaginori, Mosanyugina, Sasa, Rabbitum : Kurozozo, Kobusoso, Hanezozo, Sozonohana, Hanegusa: Hanegusa, Kanegusa, Kozanemo: Kozanemo, Isomurasaki, Hosokozanemo, Himegoge: Himegoke, Kurohimegoke, Hiodoshig, Hoshigusa Suginasugusa, Isobasho Genus: Isobasho, Fujimatsumo Genus: Fujimatsumo, Sawtooth Lilium: Hatakesakinokokihiba, Kawamozuku: Kawamozuku, A Kawamozuku, Himekawamozuku,
Ideyugogome: Ideyugogome, Okitimozuku: Okitimozuku, Itogusa, Chinorimo: Chinorimo, Chisginori: Chisinori, etc.).

Axle algae (Characta spp., Rhododendron spp.,
Hossiturimo: Hossiturimo, Lichnotumnus, Phalaenopsis: Himejira, Chaboflavidium, Tripera etc., Yellow algae (Hikarimo: Hikarimo etc.) and the like.

Materials derived from animal raw materials include cockscomb extract, cow or pig, human placenta extract, cow or pig stomach, duodenum, intestine, spleen extract or decomposition product thereof, cow or pig. Extract of brain tissue, collagen water (acid, alkali,
Enzymes, etc.) Decomposed products, collagen derivatives such as water-soluble collagen or acylated collagen, collagen hydrolysates, elastin, elastin hydrolysates, water-soluble elastin derivatives, keratin and its decomposed products or their derivatives, silk proteins and their degradation Products or derivatives thereof, swine or bovine blood cell proteolysates (globin peptides), bovine or swine hemoglobin hydrolysates (hemin, hematin, heme, protohem,
Heme iron), milk, casein and its decomposition products or their derivatives, skim milk powder and its decomposition products or their derivatives, lactoferrin or its decomposition products, chicken egg components, fish meat decomposition products, nucleic acid-related substances (ribonucleic acid, deoxyribonucleic acid) )
etc.

Examples of the material derived from plant or animal materials include any site derived from a genetically modified product or a cell fusion,
Cells, tissues, organs, metabolites and the like can also be used.
Furthermore, for example, undifferentiated cells or cells undergoing differentiation, which are obtained by culturing cells at any site, cell, tissue, organ, or the like, can also be used.

(14) Marine components Seawater such as deep water, for example, seawater salts, dried seawater, inorganic salts obtained from the Dead Sea or the Atlantic or Pacific Ocean (sodium chloride, magnesium chloride, potassium chloride, etc.), sea mud Or mud (Fango) s, for example, sea mud or mud (constituents: silicon dioxide, titanium dioxide, aluminum oxide, iron oxide, iron oxide, manganese oxide, sodium oxide, etc.) such as Italian fango, German fango, Eifelfango, Freiburgfango, etc. Potassium oxide, magnesium oxide, calcium oxide, strontium oxide, sodium, potassium, magnesium, calcium, chromium, iron, copper, nickel, zinc, lead, manganese, arsenic, water), saintoku stone, etc.

(15) Microbial culture metabolite yeast metabolite, yeast extract, bacterial metabolite, bacterial extract, mold or actinomycete metabolite, mold or actinomycete extract, natto metabolite, natto extract, Rice fermented extract,
Fermented rice bran (red bran, white bran) extract, euglena extract or its decomposition product or water-soluble derivative thereof, trehalose or its derivative, lactic acid fermentation product of raw milk or skim milk powder, and the like.

(16) α-hydroxy acids glycolic acid, citric acid, malic acid, tartaric acid, lactic acid and the like.

(17) Inorganic pigment: anhydrous silicic acid, magnesium silicate, talc, kaolin,
Bentonite, mica, titanium mica, bismuth oxychloride, zirconium oxide, magnesium oxide, zinc oxide,
Titanium oxide, calcium carbonate, magnesium carbonate, yellow iron oxide, red iron oxide, black iron oxide, gunjou, chromium oxide,
Chromium hydroxide, carbon black, calamine, etc.

(18) UV absorber / blocker Benzophenone derivatives (2-hydroxy-4-methoxybenzophenone, 2-hydroxy-4-methoxybenzophenone-
5-sulfonic acid, sodium 2-hydroxy-4-methoxybenzophenone-5-sulfonate, dihydroxydimethoxybenzophenone, sodium dihydroxydimethoxybenzophenone-sulfonate, 2,4-dihydroxybenzophenone, tetrahydroxybenzophenone, etc., para-aminobenzoic acid derivatives ( Paraaminobenzoic acid, ethyl paraaminobenzoate, glyceryl paraaminobenzoate, amyl paradimethylaminobenzoate, octyl paradimethylaminobenzoate, etc., methoxycinnamic acid derivatives (ethyl paramethoxycinnamate, isopropyl paramethoxycinnamate,
Octyl paramethoxycinnamate, 2-ethoxyethyl paramethoxycinnamate, sodium paramethoxycinnamate, potassium paramethoxycinnamate, mono-2-diparamethoxycinnamate
Glyceryl ethylhexanoate, etc.), salicylic acid derivatives (octyl salicylate, phenyl salicylate, homomenthyl salicylate, dipropylene glycol salicylate,
Ethylene glycol salicylate, myristyl salicylate, methyl salicylate, etc.), anthranilic acid derivatives (methyl anthranilate, etc.), urocanic acid derivatives (urocanic acid, ethyl urocanate, etc.), coumarin derivatives, amino acid compounds, benzotriazole derivatives, tetrazole derivatives, imidazolines Derivatives, pyrimidine derivatives,
Dioxane derivatives, camphor derivatives, furan derivatives,
Pyrone derivative, nucleic acid derivative, allantoin derivative, nicotinic acid derivative, vitamin B6 derivative, umbelliferone, esculin, benzyl cinnamate, sinoxate, oxybenzone, dioxybenzone, octabenzone, slisobenzone, benzoresorcinol, arbutin, guaiazulene, shikonin, baicalin, Baicalein, berberine, neoheliopan, escalol, zinc oxide,
Talc, kaolin, etc.

(19) Whitening Agents Paraaminobenzoic acid derivatives, salicylic acid derivatives, anthranilic acid derivatives, coumarin derivatives, amino acid compounds,
Benzotriazole derivatives, tetrazole derivatives, imidazoline derivatives, pyrimidine derivatives, dioxane derivatives, camphor derivatives, furan derivatives, pyrone derivatives,
Nucleic acid derivatives, allantoin derivatives, nicotinic acid derivatives,
Vitamin C or its derivatives (vitamin C phosphate magnesium salt, vitamin C glucoside, etc.), vitamin E or its derivatives, kojic acid or its derivatives, oxybenzone, benzophenone, arbutin, guaiazulene, shikonin, baicalin, baicalein, berberine, placenta extract , Ellagic acid, lucinol and the like.

(20) Tyrosinase activity inhibitor Vitamin C or a derivative thereof (vitamin C phosphate magnesium salt, vitamin C glucoside or the like), hydroquinone or a derivative thereof (hydroquinone benzyl ether or the like), kojic acid or a derivative thereof, vitamin E or Derivatives thereof, N-acetyltyrosine or derivatives thereof, glutathione, hydrogen peroxide, zinc peroxide, placental extract, ellagic acid, arbutin, rucinol, silk extract, plant extract (chamomile, mulberry, gardenia, touki, warmoko,
Clara, mugwort, honeysuckle, yellowfin, amberjack, matsuhodo, adlay barley, odorisium, hops, hawthorn, eucalyptus, achillea millefolium, althea, keihi, mankeishi, hamamelis, yamaguwa, extended life grass, bellflower, toshishi, maizeko, sun dried, mao, (Sengyu, Dokkatsu, Psycho, Bohu, Hamabofu, Ogon, Peony, Peony, Genoshoko, Kakkon, Licorice, Gotobiko, Aloe, Shouma, Safflower, Green Tea, Black Tea, Asenyaku).

(21) Melanin pigment reduction / decomposition substance Phenylmercury hexachlorophene, mercuric oxide, mercurous chloride, aqueous hydrogen peroxide, zinc peroxide, hydroquinone or a derivative thereof (hydroquinone benzyl ether)
etc.

(22) Turnover promoting action / cell activator hydroquinone, lactic acid bacteria extract, placenta extract, reishi extract, vitamin A, vitamin E, allantoin, spleen extract, thymus extract, yeast extract, fermented milk extract, plant extract (Aloe, Ogon, Horsetail, Gentian, Burdock,
Sicon, carrot, hamamelis, hop, yokunin,
Odorikosou, Assemblage, Touki, Toukensenka, Amacha, Hypericum, Cucumber, Periwinkle,
Rosemary, parsley) etc.

(23) Astringent Succinic acid, allantoin, zinc chloride, zinc sulfate, zinc oxide, calamine, zinc paraphenol sulfonate, aluminum potassium sulfate, resorcinol, ferric chloride, tannic acid (including catechin compound), etc. .

(24) Active oxygen scavenger SOD, catalase, glutathione peroxidase and the like.

(25) Antioxidant Vitamin C or a salt thereof, stearic acid ester, vitamin E or a derivative thereof, nordihydroguaselethenoic acid, butylhydroxytoluene (BHT), butylhydroxyanisole (BHA), hydroxytyrosol, Parahydroxyanisole, propyl gallate, sesamol,
Sesamolin, gossypol, propolis, etc.

(26) Lipid peroxide production inhibitor β-carotene, plant extract (cultured sesame cells, amateur,
Hypericum, Hamamelis, Clover, Melissa, Emisoso, Birch, Salvia, Rosemary, Minami Tenji, Agetsu, Ginkgo, Green Tea) and the like.

(27) Anti-inflammatory agent Ictamole, indomethacin, kaolin, salicylic acid, sodium salicylate, methyl salicylate, acetylsalicylic acid, diphenhydramine hydrochloride, d-camphor,
dl-camphor, hydrocortisone, guaiazulene, camazulene, chlorpheniramine maleate, glycyrrhizic acid or its salt, glycyrrhetinic acid or its salt, licorice extract, sicon extract, age extract, propolis and the like.

(28) Antibacterial, bactericidal and disinfecting agents acrinol, sulfur, calcium gluconate, chlorhexidine gluconate, sulfamine, mercurochrome, lactoferrin or a hydrolyzate thereof, alkyl diaminoethyl glycine chloride solution, triclosan, sodium hypochlorite, Chloramine T, salad powder, iodine compound,
Iodoform, sorbic acid or a salt thereof, propionic acid or a salt thereof, salicylic acid, dehydroacetic acid, parahydroxybenzoates, undecylenic acid, thiamine lauryl sulfate, thiamine lauryl nitrate, phenol, cresol, p-chlorophenol, p- Chloro-m-xylenol, p-chloro-m-cresol, thymol, phenethyl alcohol, O-phenylphenol, Irgasan CH3565,
Halocarban, hexachlorophen, chlorohexidine, ethanol, methanol, isopropyl alcohol, benzyl alcohol, ethylene glycol, propylene glycol, 2-phenoxyethanol, 1,2-pentanediol, zinc pyridione, chlorobutanol, isopropylmethylphenol, nonionic surfactant (Polyoxyethylene lauryl ether, polyoxyethylene nonyl phenyl ether, polyoxyethylene octyl phenyl ether, etc.), amphoteric surfactant, anionic surfactant (sodium lauryl sulfate, potassium lauroyl sarcosine, etc.), cationic surfactant (odor, etc.) Cetyltrimethylammonium chloride, benzalkonium chloride, benzethonium chloride, methylrosaniline chloride), formaldehyde, hexamine, yellowtail Ant Green, Malachite Green, Crystal Violet, Jarmal, Photosensitizer No. 101, Photosensitizer No. 201, Photosensitizer No. 401, N-long-chain acyl basic amino acid derivatives and their acid addition salts, zinc oxide, hinokitiol, kudin, propolis, etc. .

(29) Moisturizer Glycerin, propylene glycol, 1,3-butylene glycol, hyaluronic acid or its salt, polyethylene glycol, chondroitin sulfate or its salt, water-soluble chitin or its derivative or chitosan derivative, pyrrolidone carboxylic acid or its Salt, Sodium Lactate, Mini Sasanishiki Extract, Bacillus Natto Metabolite, Natto Extract, Loofah Water, White Birch or Akamatsu Sap

(30) Inhibitors of elastase activity Diisopropyl fluorophosphate, plant extracts (Ougon, Hypericum perforatum, Clara, Mulberry leaves, Calyx, Gennoshoko, Comfrey, Salvia, Agaricus japonicus, Bodaiju, Botanpi), seaweed extracts and the like.

(31) Hair preparations Selenium disulfide, alkylisoquinolinium bromide solution, zinc pyrithione, biphenamine, thianthol, castal tincture, ginger tincture, capsicum tincture, quinine hydrochloride, strong aqueous ammonia, potassium bromate, bromate Sodium, thioglycolic acid and the like.

(32) Antiandrogens Estrogen (eg, estrone, estradiol, ethinylestradiol), isoflavones, oxendrones and the like.

(33) Peripheral vascular blood flow promoter Vitamin E or a derivative thereof, assembly extract, garlic extract, carrot extract, aloe extract, gentian extract, touki extract, cepharanthin, carpronium chloride, minoxidil and the like.

(34) Stimulants Pepper tincture, vanillamide nonylate, tincture tincture, tincture tincture, peppermint oil, l-menthol, camphor, benzyl nicotinate and the like.

(35) Metabolic activator Photosensitizer No. 301, hinokitiol, pantothenic acid or a derivative thereof, allantoin, placenta extract, biotin, pentadecanoic acid glyceride and the like.

(36) Antiseborrheic agent pyridoxine or a derivative thereof, sulfur, vitamin B6
etc.

(37) Keratolytic agent Resorcin, salicylic acid, lactic acid, urea and the like.

(38) Oxidizing agent Hydrogen peroxide solution, sodium persulfate, ammonium persulfate, sodium perborate, urea peroxide, sodium percarbonate, sodium tripolyphosphate, sodium bromate, potassium bromate, pyrroline peroxide Sodium silicate, sodium orthophosphate, sodium silicate hydrogen peroxide adduct, sodium sulfate hydrogen peroxide adduct, sodium chloride hydrogen peroxide adduct, β-tyrosinase enzyme solution,
Mushroom extract and the like.

(39) Hair remover Strontium sulfate, sodium sulfide, barium sulfide,
Inorganic reducing agents such as calcium sulfide, thioglycolic acid or salts thereof (calcium thioglycolate, sodium thioglycolate, lithium thioglycolate, magnesium thioglycolate, strontium thioglycolate) and the like;

(40) Hair swelling agent Ethanolamine, urea, guanidine and the like.

(41) Dyes 5-aminoorthocresol, 2-amino-4-nitrophenol, 2-amino-5-nitrophenol, 1-amino-4-methylaminoanthraquinone, 3,3'-iminodiphenol ,
2,4-diaminophenoxyethanol hydrochloride, 2,4-diaminophenol hydrochloride, toluene-2,5-diamine hydrochloride, nitroparaphenylenediamine hydrochloride, paraphenylenediamine hydrochloride, N-phenylparaphenylenediamine hydrochloride, metaphenylenediamine hydrochloride, ortho Aminophenol, N-phenylparaphenylenediamine acetate, 1,4-diaminoanthraquinone, 2,6-diaminopyridine, 1,5-dihydroxynaphthalene, toluene-2,5-diamine, toluene-3,4-
Diamine, nitroparaphenylenediamine, paraaminophenol, paranitroorthophenylenediamine, paraphenylenediamine, paramethylaminophenol,
Picramic acid, sodium picramate, N, N'-bis (4-aminophenyl) -2,5-diamino-1,4-quinonediimine, 5- (2-hydroxyethylamino) -2-methylphenol, N-phenyl Paraphenylenediamine, metaaminophenol, metaphenylenediamine, 5-aminoorthocresol sulfate, 2-amino-5-nitrophenol sulfate,
Orthoaminophenol sulfate, orthochloroparaphenylenediamine sulfate, 4,4'-diaminodiphenylamine sulfate, 2,4-diaminophenol sulfate, toluene-2,5-sulfate
Diamine, nitroparaphenylenediamine sulfate, paraaminophenol sulfate, paranitroorthophenylenediamine sulfate, paranitrometaphenylenediamine sulfate, paraphenylenediamine sulfate, paramethylaminophenol sulfate, metaaminophenol sulfate, metaphenylenediamine sulfate, catechol, diphenylamine , Α-naphthol, hydroquinone, pyrogallol, phloroglucin, gallic acid, resorcin, tannic acid, 2-hydroxy
-5-nitro-2 ', 4'-diaminoazobenzene-5'-sulfonic acid sodium salt, hematein and the like.

(42) Flavors Natural animal flavors such as musk, civet, castorium, ambergris, anise essential oil, angelica essential oil, ylang-ylang essential oil, iris essential oil, fennel essential oil, orange essential oil, cananga essential oil, caraway essential oil, cardamom essential oil, Guayakwood essential oil, cumin essential oil, black letter essential oil, cinnamon essential oil, cinnamon essential oil, geranium essential oil, copaiba balsam essential oil, Coriandel essential oil, perilla essential oil, cedarwood essential oil, citronella essential oil, jasmine essential oil, ginger grass essential oil, cedar essential oil, spearmint essential oil, western Mentha essential oil, Greater Fengxiang essential oil, Tuberose essential oil, T-shaped essential oil, Orange flower essential oil, Winter green essential oil, Truval sam essential oil, Batturi essential oil, Rose essential oil, Palmarosa essential oil, Cypress essential oil, Hiba essential oil,
Sandalwood essential oil, Petit glen essential oil, Bay essential oil, Vetiva essential oil, Bergamot essential oil, Peruvian balsam essential oil, Boad rose essential oil, camphor essential oil, mandarin essential oil, Eucalyptus essential oil, lime essential oil, lavender essential oil, linaloe essential oil, lemongrass essential oil, lemon essential oil, rosemary Vegetable flavors such as essential oils and Japanese peppermint essential oils, and other synthetic flavors.

(43) Dyes / Colorants Red cabbage dye, red rice dye, madder dye, anato dye, squid dye, turmeric dye, ende dye, krill dye, persimmon dye, caramel, gold, silver, gardenia dye, corn dye , Onion pigment, tamarind pigment, spirulina pigment, buckwheat whole plant pigment, cherry pigment, laver pigment, hibiscus pigment, grape juice pigment, marigold pigment, purple potato pigment, purple yam pigment, lac pigment, rutin and the like.

(44) Others Hormones, sequestering agents, pH adjusters, chelating agents, preservatives / anti-binders, fresheners, stabilizers, emulsifiers,
Vegetable protein and its degradation products, animal and vegetable polysaccharides and their degradation products, animal and vegetable glycoproteins and their degradation products, blood flow enhancers, anti-inflammatory agents, anti-inflammatory agents, anti-allergic agents, wound healing agents, Foaming agents, thickeners, enzymes, purified water (electronic water, small clusters, etc.), oral agents, deodorants / deodorants, bittering agents, seasonings, etc. are raised. An additive or synergistic improvement of the inventive or other cosmetic effects can be expected.

The method for adding the elastase activity inhibitor and the cosmetic composition of the present invention to the cosmetic composition may be added in advance or during the production, and may be appropriately selected in consideration of workability. good.

[0077]

EXAMPLES The present invention will now be described with reference to production examples, test examples, and prescription examples, but the present invention is not limited to these examples.

(Preparation Example 1) 100 g of various dried plants such as horse clover, crow stalk, lingonberry, corn bean, hamasuge, and terrestris were heated and extracted with purified water (about 80 ° C.) for about 5 hours, filtered and extracted (dried liquid). Solid content: about 0.1-2.5%)
About 1.0 kg.

(Production Example 2) 100 g of various dry plants of horseshoe clover, crow stalk, lingonberry, horse chestnut, hamasuge, terrestris were immersed in a 50% ethanol solution, extracted at room temperature for 5 days and nights, and then filtered to extract (dry) Solid content:
About 0.1-2.5%).

(Production Example 3) 100 g of various dried plants such as horse clover, crow vine, lingonberry, horse chestnut, hamasuge and terrestris were purified in 70% ethanol solution, 70% 1,3-butylene glycol solution, or 60% propylene glycol solution, or purified. After being immersed in water (about 30 ° C.) and extracted at room temperature for 5 days and nights, it is filtered and the extract (dry solid content: about 0.1 to 3.0)
%) Of about 1.0 kg.

(Test 1) Elastase activity inhibition test "Test method and evaluation method" The elastase activity inhibition effect of various plant extracts was measured using pancreatic elastase and a synthetic substrate N-succinyl-ala-ala-ala-p-nitroanilde. Was evaluated. The substrate was adjusted to 0.1 M with dimethyl sulfoxide, and a 1 mM solution diluted 100-fold with a buffer at the time of use was used. The enzyme was adjusted to 0.05 unit / mL with a buffer. 100 μL of the substrate was reacted with 50 μL of the enzyme and 50 μL of the inhibitor (sample) at 37 ° C. for 30 minutes, and then the absorbance was measured at 405 nm, and the inhibition rate was calculated by the following equation (1). The buffer was 0.05M Tris-HCl buffe
Using r (pH 8.8), the results are shown in FIG. a. Sample The elastase activity inhibition test sample was subjected to the test using the extract (solid content: adjusted to 0.01%) obtained in Production Example 2 of the present invention. As a comparative control, the same concentration of dipotassium glycyrrhizinate was used.

<Equation 1> Inhibition rate (%) = 100− (presence of inhibitor / no inhibitor) × 100

(Test Results) As shown in FIG. 1, as shown in FIG.
It was confirmed that various plant extracts of the nutsedge and Tribulus terrestris have an effect of significantly suppressing elastase activity.

(Test 2) Safety test (1) Primary skin irritation test Various plant extracts obtained in Production Examples 1 to 3 were prepared with purified water so that the dry solid concentration was about 0.5%. This was applied to the skin of a Japanese white rabbit (female, 3 animals per group, weighing about 2.3 kg) whose back was shaved. At 24, 48, and 72 hours after application, evaluation was performed using erythema and edema as indices based on the criteria of Draize. As a result, no erythema and edema were observed in all animals, and it was judged that there was no problem with regard to primary skin irritation.

(Test 3) Safety Test (2) Skin Cumulative Irritation Test Similarly, various plant extracts obtained in Production Examples 1 to 3 were purified water-purified so that the dry solid concentration was about 0.5%. Hartley guinea pigs prepared and shaved on the back (female, group 3
Once a day, 5 times a week, 0.5 mL
/ Animal was applied. Application was performed over two weeks and shaving was performed on the last application day of each week. Evaluation was performed using erythema and edema as indices based on the criteria of Draize on each application day and the day after the last application day. The result is 2 in all animals.
No erythema and edema were observed over the week, and it was judged that there was no problem with respect to the cumulative skin irritation.

(Test 4) Safety Test (3) Single Dose Toxicity Test The various plant extracts obtained in Production Examples 1 to 3 were adjusted with purified water to a concentration of 12.5%. kg quantity,
Before the test, ddy mice (male and female, 5 animals per group, 5 weeks old) which had been fasted for 4 hours were orally administered, and the appearance and degree of toxic symptoms were observed over time. As a result, no abnormality was observed in all the mice for 14 days, and no abnormalities were found in the dissection results. Therefore, the LD50 was 2,000 mg / kg or more, and it was determined that the substance was safe.

(Prescription Examples) Production of Elastase Activity Inhibitor and Cosmetic Composition In accordance with the above evaluation results, the following prescription examples are shown. Each prescription example may be one produced by a conventional method in the production of each product. , Only the blending amount is shown. Further, the present invention is not limited to these.

(Formulation Example 1) Emulsion weight% 1. Squalane 5.0 2. Olive oil 5.0 3. Jojoba oil 5.0 4. Cetyl alcohol 1.5 5. Glycerin monostearate 2.0 6. Polyoxyethylene (20) cetyl ether 3.0 7. Poly Oxyethylene (20) soorbitan monooleate 2.0 8.1,3-butylene glycol 1.0 9. Glycerin 2.0 10. A: Extract of Ranus japonicus from Production Example 2 B: Raspberry extract of Production Example 2 C: Extract of lingonberry of Production Example 2 Liquid D: Extract of corn oyster extract of Production Example 2 E: Extract of Lepidoptera of Production Example 2 F: Extract of Tribulus terrestris of Production Example 2 * Any one of extracts A to F 5.0 11. Preservative (paraoxybenzoic acid) Ester) Appropriate quantity 12.Perfume Appropriate quantity 13.Purified water 100 residue

(Formulation Example 2) Emulsion Weight% 1. Squalane 8.0 2. Jojoba oil 7.0 3. Glyceryl paraaminobenzoate 1.0 4. Ethyl urocanate 1.0 5. Magnesium salt of vitamin C phosphate ester 1.0 6. Cetyl alcohol 1.5 7. Glycerin monostearate 2.0 8. Polyoxyethylene (20) cetyl ether 3.0 9. Polyoxyethylene (20) soorbitan monooleate 2.0 10.1,3-butylene glycol 1.0 11.1,2-pentanediol 1.0 12. Glycerin 2.0 13. Raspberry extract of Production Example 2 3.0 14. Raspberry extract of Production Example 2 3.0 15. Water extract of swine placenta 3.0 16. Preservative (paraoxybenzoate) qs 17. Purified water 100 residue

(Formulation Example 3) Cosmetic oil weight% 1. Liquid paraffin 30.0 2. Squalane 20.0 3. Olive oil 20.0 4. Isopropyl palmitate 10.0 5. Grapefruit fruit or leaf hot water extract 3.0 6. Cowberry of Production Example 2 Extract 3.0 7. Tow extract extract of Production Example 2 3.0 8. Olive oil 1.0 9. Shea butter 1.0 10. Butylhydroxyanisole 0.1 11. Vitamin E derivative 0.1 12. Preservative (benzalkonium chloride) qs 13. Fragrance ( Musk water) Appropriate amount 14.Residual water to be 100

(Formulation Example 4) Flexible lotion% by weight 1. Glycerin 5.0 2.1,3-butylene glycol 5.0 3. Polyoxyethylene sorbitan monolaurate (20E.O) 1.0 4. Ethanol 15.0 5. Cowberry peel or fruit 30 % Ethanol extract 1.0 6. Rose hip fruit 30% ethanol extract 1.0 7. Grapefruit fruit or leaf 50% ethanol extract 1.0 8. Kiwi fruit 50% ethanol extract 1.0 9. Antibacterial and preservative (lactoferrin solution) qs 10 .Perfume (Western lightly loaded water) Appropriate amount 11. Purified water 100 residue

(Formulation Example 5) Astringent lotion weight% 1. Sorvitol 2.0 2. POE (20) oleyl alcohol 1.0 3. Ethanol 15.0 4. Echinacea spp. Fruit 50% 1,3-butylene glycol extract 2.0 5. Assembly whole plant 50% 1,3-butylene glycol extract 2.0 6. Clara whole plant 50% ethanol extract 1.0 7. Sage whole plant 50% ethanol extract 1.0 8. Allantoin 0.2 9. Astringent (zinc sulfocarbonate) 0.2 10. Antibacterial・ Preservative (thiamine lauryl sulfate) proper amount 11.Fragrance (lavender water) proper amount 12.Purified water 100 residue

(Formulation Example 6) Two-layer type lotion (liquid to liquid type)% by weight 1. Squalane 8.0 2. POE sorbitan tetraoleate 0.3 3. Sorbit 1.0 4. Ethanol 15.0 5. Raspberry root extract 30% ethanol extraction Solution 2.0 6. Nutsedge rhizome 30% diglycerin extract 2.0 7. Rhubarb root 30% glycerin extract 1.0 8. Fucoidan from seaweed Mozuku 0.2 9. Ascorbic acid 0.2 10. Astringent (calamine) 0.1 11. Preservative (phenoxyethanol) Appropriate amount 12.Fragrance (lemon water) Appropriate amount 13.Purified water 100 residue

(Formulation Example 7) Carmine lotion (liquid to solid) wt% 1. Glycerin 3.0 2.1,3-butylene glycol 5.0 3. Ethanol 15.0 4. Iron oxide (Bengara) 0.2 5. Zinc oxide 0.5 6. Kaolin 2.0 7.Tender beet rhizome 50% propylene glycol extract 2.0 8. Yarrow whole plant 50% propylene glycol extract 2.0 9. Panax ginseng root 50% propylene glycol extract 2.0 10. Carrot root 50% propylene glycol extract 1.0 11. Pig Placenta Enzyme Decomposition Extract 1.0 12. Camphor 0.2 13. Phenol 0.03 14. Preservative (Photosensitizer 201 & 401) Appropriate amount 15. Perfume (Bodhi tree water) Appropriate amount 16. Purified water 100

(Formulation Example 8) Pack weight% 1. Polyvinyl alcohol 15.0 2. Sodium carboxymethyl cellulose 5.0 3. Propylene glycol 3.0 4. Ethanol 10.0 5. Tribulus terrestris extract 1.0 of Preparation Example 1 6. Echinacea extract of Preparation Example 1 1.0 7. Melissa leaf or stem 50% ethanol extract 1.0 8. Royal jelly 50% ethanol extract 1.0 9. Trehalose solution 1.0 10. Dried seawater 1.0 11. Preservative (paraoxybenzoate) qs 12. Fragrance (rose) Water) Appropriate amount 13. Residual water with 100 purified water

(Formulation Example 9) Peel-off pack% by weight 1. Glycerin 5.0 2. Propylene glycol 4.0 3. Polyvinyl alcohol 15.0 4. Ethanol 8.0 5. Polyoxyethylene glycol 1.0 6. Pantothenyl ethyl ether 1.0 7. Preparation example 2 Extract of cornflower 2.0 2.0 Mint leaf or stem 50% ethanol extract 2.0 9. Spiral leaf or stem 50% ethanol extract 2.0 10. Safflower whole plant 50% ethanol extract 2.0 11. Yuzu fruit 50% ethanol extract 2.0 12. Glycyrrhetinic acid 0.1 13. Preservative (paraoxybenzoic acid ester) suitable amount 14. Fragrance (hinoki water) proper amount 15. Purified water 100 residue

(Formulation Example 10) Cold cream weight% 1. Salicone beeswax 11.0 2. Liquid paraffin 22.0 3. Lanolin 10.0 4. Olive oil 5.0 5. Chamomile oil 5.0 6. Palm oil 5.0 7. Borax 0.5 8. Extract of Rhododendron rhizome Liquid 2.0 (ethanol: 1,3-butylene glycol = 1: 1 extraction solvent) 9.Birch bark extract 2.0 (ethanol: 1,3-butylene glycol = 1: 1 extraction solvent) 10.Liquid shea fat 1.0 11.Preservative Reagent (acrinol) 0.1 12. Appropriate amount of fragrance (sage water) 13. Residual to make purified water 100

(Formulation Example 11) Emollient cream% by weight 1. Stearic acid 2.0 2. Stearyl alcohol 7.0 3. Reduced lanolin 2.0 4. Squalane 5.0 5. Octyldodecanol 6.0 6. Polyoxyethylene cetyl ether (25E.O.) 3.0 7. Lipophilic glyceryl monostearate 2.0 8. Propylene glycol 5.0 9. Biloba leaf or stem hot water extract 3.0 10. Turmeric rhizome hot water extract 3.0 11. Rose hip leaf or fruit hot water extract 3.0 12. Dokudami Leaf or stem hot water extract 3.0 13. Rosemary leaf or flower hot water extract 2.0 14. Preservative (paraben) qs 15. Fragrance (cinch water) qs 16. Purified water 100 residue

(Formulation Example 12) Face wash cream% by weight 1. Myristic acid 25.0 2. Stearic acid 5.0 3. Tallow fatty acid 5.0 4. Propylene glycol 10.0 5. Potassium hydroxide 6.0 6. Coconut oil fatty acid diethanolamide 6.0 7. Nutsedge tuber Or corm extract 2.0 (ethanol: 1,3-butylene glycol = 1: 2 extraction solvent) 8. Kakkon hot water extract 2.0 9. 20% valerian root 1,3-butylene glycol extract 2.0 10. Loofah fruit or stem 50% 1,3-butylene glycol extract 2.0 11. Dipotassium glycyrrhizinate 1.0 12. Preservative (salicylic acid) 0.1 13. Perfume (sage water) qs 14. Purified water 100

(Formulation Example 13) Face Wash Cream% by Weight 1. Stearic acid 10.0 2. Palmitic acid 10.0 3. Myristic acid 12.0 4. Lauric acid 4.0 5. Oleyl alcohol 1.5 6. Lanolin derivative (EO adduct) 1.0 7. Glycerin 18.0 8. Potassium hydroxide 6.0 9. A: Amanita japonicus extract of Production Example 2 B: Raspberry extract of Production Example 2 C: Bilberry extract of Production Example 2 D: Pea extract of Production Example 2 E: Production Example No. 2 extract F .: Tribulus terrestris extract of Production Example 2 * Extract of any one of A to F 5.0 10. Royal jelly extract 1.0 (Ethanol: 1,3-butylene glycol = 1: 1 extract) 11. Dipotassium glycyrrhizinate 0.1 12. Preservative (salicylic acid) 0.1 13. Perfume (Tokimizu) Appropriate amount 14. Purified water 100 residue

(Formulation Example 14) Body soap weight% 1. Potassium laurate 15.0 2. Potassium myristate 5.0 3. Propylene glycol 5.0 4. 70% Raspberry rhizome 1,3-butylene glycol extract 1.0 5. Calendula flower 70% 1,3-butylene glycol extract 0.5 6. Toki rhizome 70% 1,3-butylene glycol extract 0.5 7. Polyethylene powder 0.5 8. Hydroxypropyl chitosan solution 0.5 9. Amino acids (glycine, glutamine, etc.) 0.5 10 .Preservative (undecylenic acid, phenol) proper amount 11. pH adjuster proper amount 12. Flavor (lavender water) proper amount 13. Purified water 100 residue

(Formulation Example 15) Sunscreen cosmetics (O / W type)% by weight 1. Oxybenzone 2.0 2. Octyl paramethoxycinnamate 5.0 3. Squalane 10.0 4. Vaseline 5.0 5. Stearyl alcohol 3.0 6. Stearic acid 3.0 7. Glyceryl monostearate 2.0 8. Ethyl polyacrylate 1.0 9.1,3-butylene glycol 6.0 10. Disodium edetate 0.1 11. Triethanolamine 1.0 12. Titanium dioxide 5.0 13. Tritic acid extract of 50% of Tribulus terrestris fruit 0.5 14. Honeysuckle whole plant 50% dipropylene glycol extract 0.5 15. Mulberry bark 50% dipropylene glycol extract 0.5 16. Purple root 50% dipropylene glycol extract 0.5 17. Preservative (benzyl parahydroxybenzoate) qs 18 .Fragrance (apple water) Appropriate amount 19. Residual water with 100 purified water

(Formulation Example 16) Sunscreen cosmetics (oil type) wt% 1. Liquid paraffin 70.0 2. Ethyl paraaminobenzoate 1.0 3. Tetrahydroxybenzophenone 1.0 4. Cetyl octanoate 25.0 5. Cowberry fruit or pericarp 30% 1,3-butylene glycol extract 1.0 6. mallow flower or leaf 50% 1,3-butylene glycol extract 1.0 7. chrysanthemum 30% 1,3-butylene glycol extract 0.5 8. adlay whole plant 50% 1,3 -Butylene glycol extract 0.5 9. Fencil fruit 30% 1,3-butylene glycol extract 2.0 10. Appropriate amount of antioxidant (butylhydroxytoluene) 11. Appropriate amount of perfume (Bodyju water)

(Formulation Example 17) Cream foundation (O / W type) weight% 1. stearic acid 4.0 2. glyceryl monostearate 3.0 3. cetanol 1.5 4. isopropyl myristate 7.0 5. liquid paraffin 10.0 6. salami beeswax 3.0 7. Triethanolamine 1.5 8. Glycerin 3.0 9. Bentonite 1.0 10. Titanium oxide 8.0 11.2,4-Dihydroxybenzophenone 8.0 12. Kaolin 3.0 13. Talc 3.0 14. Color pigment (iron iron oxide) 1.0 15. Tow root rhizome or Root hot water extract dry powder 0.2 16. Dokudami flower flower hot water extract dry powder 0.2 17. Preservative (phenoxyethanol) qs 18. Fragrance (rose water) qs 19. Purified water 100 residue

(Formulation Example 18) Shampoo wt% 1. Triethanolamine lauryl sulfate 5.0 2. Sodium polyoxyethylene lauryl ether sulfate 12.0 3.1,3-butylene glycol 4.0 4. Diethanolamide laurate 2.0 5. Disodium edetate 0.1 6.Natural root extract or rhizome 20% glycerin extract 2.0 7.Rose hip fruit or leaf 20% 2,3-butylene glycol extract 2.0 8. Hamamelis bark hot water extract 2.0 9. Sandalwood heartwood 30% 1,4-butylene Glycol extract 2.0 10. Hydroxypropyl chitosan solution 2.0 11. Porcine placenta enzyme decomposition solution 2.0 12. Mucopolysaccharide solution 1.0 13. Antibacterial and preservative (photosensitive element 101) qs 14. pH adjuster qs 15. Fragrance ( Sandalwood water) Suitable amount 16. Residual water to be 100 purified water

(Formulation Example 19) Rinse weight% 1. Stearyl trimethyl ammonium chloride 2.0 2. Cetostearyl alcohol 2.0 3. Polyoxyethylene lanolin ether 3.0 4. Propylene glycol 5.0 5. Raspberry rhizome 50% 1,2-butylene glycol extraction Liquid 1.0 6. mallow leaf or branch 50% 1,2-butylene glycol extract 1.0 7. matsuhodo sclerotium 50% 1,2-butylene glycol extract 1.0 8. loquat leaf 50% 1,2-butylene glycol extract 1.0 9. Hydroxyethyl chitosan solution 1.0 10. Trehalose solution 1.0 11. Hydrolyzed silk solution 1.0 12. Antibacterial and preservative (benzalkonium chloride) qs 13. perfume (lavender water) qs 14. Purified water 100

(Formulation Example 20) Rinse weight% 1. Stearyl trimethylammonium chloride 2.0 2. Cetostearyl alcohol 2.0 3. Polyoxyethylene lanolin ether 3.0 4. Propylene glycol 5.0 5. Ethylene glycol 3.0 6. Tribulus pericarp or fruit 50% 1,3-butylene glycol extract 1.0 7. Usavasaicin rhizome 30% ethanol extract 1.0 8. Trehalose solution 1.0 9. Hydrolyzed keratin solution 1.0 10. Appropriate amount of antibacterial and preservative (benzalkonium chloride) 11. Fragrance (Chamois water) Appropriate amount 12. Residual water to be 100 purified water

(Formulation Example 21) Hair liquid% by weight 1. Ethanol 29.0 2. Polyoxypropylene butyl ether phosphoric acid 10.0 3. Polyoxypropylene monobutyl ether 5.0 4. Triethanolamine 1.0 5. Umanotsukusa root hot water extract 2.0 6. Panax ginseng root hot water extract 2.0 7. Iris root 50% ethanol extract 1.0 8. Melissa whole plant 50% ethanol extract 1.0 9. Birch sap 1.0 10. Carpronium chloride 0.3 11. Hinokitiol 0.5 12. Keratin decomposition solution 1.0 13. Antibacterial and preservative (paraben, benzalkonium chloride) proper amount 14.Fragrance (orange water) proper amount 15.Purified water 100 residue

(Formulation Example 22) Hair liquid weight% 1. Ethanol 29.0 2. Polyoxypropylene butyl ether phosphoric acid 10.0 3. Polyoxypropylene monobutyl ether 5.0 4. Triethanolamine 1.0 5. Trimethylene glycol 5.0 6. Production Example 2 Lingonberry extract 1.0 7. Lysium extract of Production Example 2 1.0 8. Parsley whole plant 50% 1,3-butylene glycol extract 0.5 9. Loquat leaf 30% ethanol extract 1.0 10. Horsetail whole plant 30% ethanol extraction Liquid 1.0 11. Azulene 1.0 12. Antibacterial and preservative (paraben, benzalkonium chloride) proper amount 13. Perfume (yuzu water) proper amount 14. Purified water 100 residue

(Formulation Example 23) Hair tonic weight% 1. Ethanol 40.0 2. Ethyl oleate 1.0 3. Polyoxyethylene (40) hydrogenated castor oil 2.0 4. A: Echinacea japonicus extract of Production Example 2 B: Production Example 2 Crow extract of Caspberry C: Extract of lingonberry extract of Preparation Example 2 D: Extract of cornflower extract of Preparation Example 2 E: Extract of Lepidoptera of Preparation Example 2 F: Extract of Tribulus terrestris of Preparation Example 2 * A to F Extract 5.0 5. Comfrey leaf or stem 50% ethanol extract 3.0 6. Citrus leaf or fruit 50% ethanol extract 3.0 7. Preservative (phenoxyethanol) qs 8. Purified water 100

(Formulation Example 24) Hair tonic weight% 1. l-menthol 0.2 2. ethanol 32.5 3. polyoxyethylene hydrogenated castor oil 0.5 4. propylene glycol 5.0 5. diphenhydramine hydrochloride 0.3 6. 2.0 7. Hot water extract of root nutsedge 2.0 8. Hot water extract of mallow flower 1.0 9. Hot water extract of cinnamon bark 1.0 10. 50% ethanol extract of burdock root 1.0 11. Carboxymethyl chitin solution 1.0 12. Vitamin E derivative 0.5 13. Antibacterial and preservative (paraben) 0.1 14. Appropriate amount of fragrance (sage water)

(Formulation Example 25) Hair restorer / hair restorer weight% 1. Ethanol 60.0 2. Tribulus terrestris fruit 50% propylene glycol extract 5.0 3. Artemisia leaf or stem 50% 1,3-butylene glycol extract 1.0 4. Vitamin E derivative 0.5 5. Pepper tincture 0.5 6. Resorcin 0.5 0.5 Dipotassium glycyrrhizinate 0.5 8. Carboxymethyl chitin solution 0.5 9. Porcine hematin solution 0.5 10. Porcine mucin solution 0.5 11. Amino acids (glycine, glutamine, etc.) 0.5 12. Antibacterial and antiseptic Reagent (paraben) 0.1 13.Perfume (rosemary water) Appropriate amount 14.Purified water 100 residue

(Formulation Example 26) Hair restorer / hair restorer% by weight 1. Ethanol 60.0 2. Ethanol extract 60% of Echinacea root 1.0 3. Ethanol extract 60% of Kakkon root 4. 4. Ethanol extract 60% of geno ginger leaf or stem 1.0 5. Cantaris tincture 0.5 6. Pantothenic acid derivative 0.5 7. Glycyrrhetinic acid 0.5 8. Resorcin 0.5 9. Salicylic acid 0.5 10. Hydroxyethyl chitosan solution 0.5 11. Elastin hydrolyzate 0.5 12. Antibacterial and preservative (paraben) 0.1 13. Fragrance (Lavender water) Appropriate amount 14. Residual water to make purified water 100

(Formulation Example 27) Granule bath agent% by weight 1. Sodium bicarbonate 58.0 2. Anhydrous sodium sulfate 30.0 3. Borax 2.0 4. Raspberry rhizome or rhizome hot water extract dry powder 5.0 5. Eucalyptus whole plant hot water Extract dry powder 5.0 6. Kemponashi fruit hot water extract dry powder 5.0 7. Pigment (Gunjo green) Appropriate amount

(Formulation Example 28) Granule bath agent% by weight 1. Sodium bicarbonate 58.0 2. Anhydrous sodium sulfate 30.0 3. Borax 4.0 4. Dried powder of soybean tuber or rhizome hot water extract 2.0 5. Mulberry leaf or stem heat Water extract dry powder 1.0 6. Satsuma mandarin peel or fruit 50% ethanol extract dry powder 1.0 7. Peach leaf 70% ethanol extract dry powder 1.0 8. Iris leaf or root 70% ethanol extract dry powder 1.0 9. Apple Juice powder 1.0 10. Pigment (Gunjo, chromium hydroxide) qs 11. Fragrance (grape water) qs

(Formulation Example 29) Coating protective agent A gauze or liniment cloth is impregnated with a formulation solution obtained by mixing an appropriate amount of a water bud root extract, an antibiotic, an anti-inflammatory agent, etc., and attached to the wound. Alternatively, the hot water extract of Echinacea purpurea root may be directly sprayed locally and covered with gauze or the like.

(Formulation Example 30) Oral freshener weight% 1. Ethanol 20.0 2. Glycerin 15.0 3. Polyoxyethylene hydrogenated castor oil 1.0 4. Saccharin 0.2 5. Chlorohexidine 0.01 6. Dry powder of corn extract extracted from Production Example 1 0.1 7. Dry powder of hot water extract of melilot flower or leaf 0.1 8. Appropriate amount of pigment (Gunjo green) 9. Residue to 100 purified water

(Formulation Example 31) Dishwashing detergent weight% 1. Alkyl (C12) glucoside 20.0 2. Polyoxyethylene (3) sodium dodecyl ether sulfate 10.0 3. Glycerin 2.0 4. Ethanol 5.0 5. Hot water extract of Tribulus terrestris fruit Dry powder 3.0 6. Rosehip fruit hot water extract dry powder 3.0 7. Cornflower head flower hot water extract dry powder 3.0 8. Purified water 100 residue

(Test 5) Use Effect Test The effect of the cosmetic composition of the present invention actually used was examined. Use test is 25 healthy adult women
A panel of 30 50-year-olds each day, morning and night
The washing was performed by applying an appropriate amount of the emulsion of Formulation Example 1 to the face over three months after washing the face. As a control, a mixture prepared by removing the various plant extracts of the present invention from the emulsion by the same method was used. The evaluation was performed according to the following criteria. The results are as shown in Table 1 and the numerical values in the table represent the number of persons.
No one complained of skin abnormalities during the use period.

"Effect of improving skin gloss and tension" Effective: Skin gloss and tension increased. Slightly effective: Skin gloss and tension increased slightly. Ineffective: No change from before use.

"Improvement effect of wrinkles and fine wrinkles" Effective: Wrinkles and fine wrinkles became inconspicuous. Somewhat effective: wrinkles and small wrinkles are slightly less noticeable. Ineffective: No change from before use.

[0122]

[Table 1]

(Test results) As shown in Table 1, the agate clover, croaker, lingonberry, eucalyptus,
It has been confirmed that the emulsion containing various plant extracts of hamasuge and terrestris significantly imparts gloss and tension to the skin, and also reduces wrinkles and fine wrinkles.

[0124]

EFFECT OF THE INVENTION The elastase activity inhibitor or cosmetic composition of the present invention containing one or more plant extracts selected from horseshoe clover, crow stalk, lingonberry, cornflower, hamasuge, terrestris has an elastase activity inhibitory action. It has been confirmed that the skin can be given a gloss and tension to prevent aging, wrinkles and fine wrinkles can be reduced, and a youthful skin condition can be maintained.
The present invention can be used for other general foods and drinks.

[Brief description of the drawings]

FIG. 1 is a diagram showing the elastase activity inhibition ratio of dipotassium glycyrrhizinate at the same concentration as various plant extracts of Echinacea purpurea, avenger, bilberry, euphorbia, hamasuge, and Tribulus terrestris, and a comparative control.

──────────────────────────────────────────────────続 き Continued on the front page (51) Int.Cl. ⁷ Identification symbol FI Theme coat ゛ (Reference) A61K 7/00 A61K 7/00 QU 7/02 7/02 A 7/06 7/06 7/075 7 / 075 7/08 7/08 7/11 7/11 7/26 7/26 7/42 7/42 7/48 7/48 7/50 7/50 A61P 17/00 A61P 17/00 17/14 17 / 14 43/00 107 43/00 107 (72) Inventor: Yuka Tsuda, 318, Asagi, Mamashou, Motosu-gun, Gifu Prefecture F-term (reference) 4C083 AA072 AA082 AA111 AA112 AA122 AA162 AB152 AB212 AB232 AB242 AB312 AB352 AB432 AB442 AC022 AC062 AC072 AC102 AC112 AC122 AC132 AC172 AC182 AC242 AC352 AC422 AC432 AC442 AC472 AC482 AC532 AC542 AC582 AC642 AC682 AC692 AC782 AC852 AC862 AC902 AD042 AD092 AD112 AD212 AD272 AD312 AD322 AD392 AD442 CC452 AD512 AD532 CC552 CC25 CC32 CC33 CC37 CC3 8 CC39 CC41 DD05 DD16 DD23 DD27 DD31 EE06 EE12 EE17 4C088 AB11 AB44 AB79 AB80 AC01 AC03 AC04 AC05 AC06 AC11 AC13 BA07 BA08 BA09 BA10 CA03 MA03 MA06 MA07 MA08 MA09 MA16 MA22 MA27 MA28 MA41 MA63 NA14 ZA59 ZA92 ZC02

Claims (2)

[Claims] 1. A member selected from the group consisting of horseshoe clover, crows, lingonberry, cornflower, hamasuge, and terrestris
An elastase activity inhibitor comprising at least one plant extract. 2. A cosmetic composition comprising the elastase activity inhibitor according to claim 1.