JP2000302634A - Cosmetic composition - Google Patents

Abstract

PROBLEM TO BE SOLVED: To obtain a highly safe cosmetic composition capable of significantly inhibiting melanin pigment production, having whitening effect, capable of significantly scavenging/inhibiting active oxygen as well, and also capable of diminishing freckles, therefore useful as a cosmetic. SOLUTION: This cosmetic composition contains extract(s) from at least one plant selected from jasmine (Jasminum L., Oleaceae), Lagerstroemia speciosa L. (lagerstroemia L., Lythraceae), Camellia L., Theaceae, and Camellia sinensis O. Kuntze; wherein, as the above extract(s), it is recommended that that (those) from various sites (e.g. flowers, heads, ear tips, female flower tips, buds, calyxes, leaves, stems, branches, branch tips) using a solvent such an methanol either directly or after ground is used and the amount of the extract(s) to be used is >=0.001 wt.% based on this composition.

Description

DETAILED DESCRIPTION OF THE INVENTION

[0001]

TECHNICAL FIELD The present invention relates to an application to a melanin production inhibitor, an active oxygen scavenger, or a cosmetic composition containing at least one plant extract selected from jasmine, banaba, uba, and puer. Things.

[0002] The field of application is, for example, applicable to all kinds of external preparations (including preparations for animals), and specifically, ampules, capsules, pills, tablets, powders, granules, solids, 1) Pharmaceuticals, 2) of liquid, gel or air bubbles
Quasi-drugs, 3) topical or systemic skin cosmetics (e.g., basic cosmetics such as lotions, emulsions, creams, ointments, lotions, oils, packs, facial cleansers and skin cleansers, massage agents) , Cleansing agent, depilatory, depilatory, shaving treatment, after-shave lotion, pre-show lotion, shaving cream, etc.),
4) Pharmaceutical or / and cosmetic preparations applied to the scalp / hair (eg, shampoos, rinses, treatments, permanent solutions, hair dyes, hair styling agents, hair tonics, hair restoration / hair restoration, etc.), 5 ) Bath agents to be poured into bath water, 6) Others, axillary odor inhibitor, deodorant, deodorant, sanitary goods, sanitary cotton, wet tissue, mouth freshener (for example,
Brushing, mouthwash, etc.).

[0003]

2. Description of the Related Art Factors determining human skin color include the amount of melanin in the epidermis, blood flow in capillaries, pigments derived from food (carotene), and the thickness of the stratum corneum. One of the most important factors is melanin pigment. The so-called liver spots (spots), sparrow egg spots (buckwheat spots), and pigmentation of the skin after sunburn are those in which the production of melanin pigments has been significantly enhanced by the activation of pigment cells present in the skin. And for women, it is one of the major worries of the skin.

[0004] The melanin pigment is produced by melanosomes, which are organelles in pigment cells (melanocytes) present in the basal layer of the epidermis, the hair root, and the outer root sheath. In the process of melanin pigment production, tyrosine is activated by tyrosine in pigment cells (melanocytes) to oxidize tyrosine,
It is converted to dopa and dopaquinone, further autoxidized, polymerized via dopachrome and 5,6-dihydroxyindole, and finally turned into a melanin pigment. The produced melanin is secreted by the dendrites of pigment cells (melanocytes) into basal cells, which divide and rise as spinous cells, reach the stratum corneum, and fall off as the stratum corneum detaches. It is going to go.

[0005] Therefore, in order to prevent or improve skin spots, spots and freckles, and darkness of the skin, it is necessary to inhibit the production process of melanin. Alternatively, it is conceivable to make already generated melanin lighter. Therefore, various whitening components have been conventionally proposed based on these ideas. For example, kojic acid or a derivative thereof, ascorbic acid or a derivative thereof, tocopherol or a derivative thereof, glutathione, hydrogen peroxide, zinc peroxide, hydroquinone monobenzyl ether, placenta extract, silk extract or plant extract (Arnica, Altea , Aloe, Japanese gourd, Japanese radish, chamomile, licorice, gardenia, genoshoko, sicon, ginger, birch, senkyu,
Gennoshoko, psycho, sasanqua, Toki, calendula, elderberry, safflower, garlic, adlay, litchi, logwood), etc. were known.

In recent years, the production of active oxygen in a living body and various effects (diseases) caused thereby have been reported. Generally, this active oxygen is also called Activated oxygens, and is roughly classified into four types, O ²⁻ , H ₂ O ₂ , .OH, and chemiluminescence. Captured as important substances involved in defense, for example, when foreign enemies (antigens) such as bacteria, viruses, and foreign substances enter the living body, phagocytic neutrophils, monocytes, and macrophages in the blood first phagocytose. Initiating action, then active oxygen is produced to dissolve the phagocytosed foreign material in the phagocytic endoplasmic reticulum, and this produced active oxygen is responsible for dissolving the phagocytosis, while It directly exerts a bactericidal action on external enemies such as bacteria and foreign substances, and plays a role of protecting them from external enemies. In other words, it has the function of eliminating antigenic substances before the immune function works.

[0007] However, if active oxygen for self-defense is produced and secreted in excess, even normal cells are lysed and stimulated, resulting in various damage reactions. Recently, many diseases and diseases induced by active oxygen have been reported. For example, fats and oils such as cholesterol in blood are oxidized by active oxygen, and vascular disorders due to arteriosclerosis in the brain and heart (stroke, myocardial infarction, etc.) It is said that during blood trauma or cerebral trauma, blood flow is impaired due to thrombus or the like, or ischemic state in blood vessels due to rapid transient atrophy, thereby causing oxygen deprivation. Therefore, in this state, it is said that xanthine dehydrogenase in the blood vessel is converted to xanthine oxidase, which generates a large amount of active oxygen in the blood in the blood vessel, causing damage to the blood vessel wall and causing fatal damage I have.

Further, regarding the relationship between the skin and the active oxygen, for example, since the skin is an organ which is in direct contact with the outside world, the active oxygen is excessively exposed to the skin by ultraviolet rays or radiation while being susceptible to environmental factors. If the state continues, it reacts with the unsaturated fatty acids of the phospholipids of the biological membrane, and the lipid peroxides are generated. The generated lipid peroxide causes arteriosclerosis, carcinogenesis, aging, membrane destruction, protein denaturation, etc., and also causes skin inflammation, edema, wrinkles, and the like. Further, as a disease due to excess active oxygen, from a cosmetic point of view, for example, herpetic dermatitis, X-ray dermatitis, burns, trauma, solar dermatitis, contact dermatitis,
Eczema, atopic dermatitis, etc.
There is a need for a substance that eliminates excess active oxygen present in a living body. In order to prevent or improve various diseases, for example, in a living body of animals and plants, superoxide dismutase (SOD), catalase, Glutathioperoxidase and other tocopherols (vitamin E), oryzanol, plant extracts (hamamelis, melissa, emisoso, birch, sage, rosemary, age, basil, ginkgo, psycho, peonies, hange, cahig, tissou, ogon, carrot ,
Licorice, ginger) and the like were used.

[0009]

However, the above-mentioned whitening component or active oxygen-eliminating substance has poor stability and solubility in a prescription system, and produces an unpleasant odor and coloring due to sedimentation and decomposition. Effect is not enough,
Furthermore, there was a problem in terms of safety, such as rash on the skin, and it was not satisfactory.

[0010]

In view of these circumstances, the present inventors have studied the effects of inhibiting melanin production and eliminating active oxygen (S
OD) The theme of development is a useful plant having an action, and as a result, one or more plant extracts selected from jasmine, banaba, puer, and uba significantly suppress the production of melanin pigment and have a whitening effect. It was confirmed. It was also confirmed that active oxygen was also significantly eliminated and suppressed. And to reduce stains and freckles on the skin. In addition, by improving dry skin and eczema and rough skin, furthermore, by providing a highly safe melanin production inhibitor, active oxygen scavenger, or cosmetic composition that can also give gloss and tension to the skin,
The present invention has been completed.

[0011]

DESCRIPTION OF THE PREFERRED EMBODIMENTS "Jasmine" used in the present invention is defined as "Oleaceae" and "Jasminum".
L.) plants: flowers of pine squirrel (Jasminum sambac (L.) Ait.),
Head flowers, spikes, female spikes, buds, calyx are used.
J. officinale L. of the congener species, J. humil
e var.revolutum (Sims) Stokes (= J.revolutum Sim
s) "and" G. grandiflorum L = Var.grandif "
lorum (L.) Bailey "can also be used.

"Banaba" is Lythracea family.
e), a plant of the genus Lagerstroemia L .: Lagerstroem speciosa Persoon (= L.flosr
eginaeRETZ) '', leaves, foliage, branches, and branch tips, but other species of the same species, L. loudonii T. et.
B.), Lagerstroemia L.indica L. (= L.chinensis La.
m.) ", L. subcostata Koehne, L. fauriei Koehne,
(L. amabilis Makino) can also be used.

"Uva" means a plant of the family Camellia (Theaceae) and Camellia L. (Camellia sinens).
is (L.) O.Kuntze (= Thea sinensis L.)
Branches and branches are used, but fermented tea tree is collected from July to September at the end of the dry season brought by Sri Lanka's southwest monsoon, and Uba of tea tree (Assam species) is used.

[0014] The term "puer" means a camellia family (Theaceae),
Camellia (Camellia L.) Plant: Tea Tree "Camellia si"
nensis (L.) O. Kuntze (= Thea sinensis L.) "using leaves, foliage, branches and branches, but after steaming the persimmon to kill enzymes, fermented by deposited microorganisms (molds) It uses a Puer belonging to Chinese tea tree black tea.

The extracts of jasmine, banaba, uba, and puer used in the present invention are defined as various parts of each plant (flower, head flower, spike, female spike, bud, calyx, leaf, foliage, branch, branch) Exploited as it is or after crushing. Alternatively, it is extracted with a solvent as it is or after pulverization.

Examples of the extraction solvent for the plant extract include water, alcohols (eg, lower alcohols such as methanol, anhydrous ethanol and ethanol, or polyhydric alcohols such as propylene glycol and 1,3-butylene glycol), acetone and the like. Ketones, ethyl ether, dioxane, acetonitrile, esters such as ethyl acetate, organic solvents such as xylene, benzene, chloroform can be used alone or in any combination of two or more kinds. It can also be used in a state where the extracts are combined.

The plant extracts of jasmine, banaba, uba, and puer may be dried, concentrated, diluted, or mixed depending on the type and form of the melanin production inhibitor, active oxygen scavenger, or cosmetic composition to be applied. Etc. may be arbitrarily prepared.

Although the production method is not particularly limited, it is usually sufficient to be within the range of the boiling point of the solvent at normal temperature and normal pressure. After extraction, filtration or use of an ion exchange resin is carried out.
A solution, paste, gel, or powder may be obtained by decoloring and purifying. In many cases, it can be used as it is, but if necessary, further purification treatment such as deodorization and decolorization may be added as long as the effect is not affected. An activated carbon column or the like may be used, and ordinary means generally applied to the extracted substance may be arbitrarily selected.

The jasmine, banaba, uba, and puer plant extracts of the present invention can be contained in a melanin production inhibitor, an active oxygen scavenger, or a cosmetic composition, and the content thereof is not particularly limited. However, melanin production inhibitor, active oxygen scavenger, or the type and quality of the cosmetic composition,
Varies slightly depending on the degree of effect expected, usually 0.00
1% by weight or more (hereinafter, represented by weight%), preferably 0.2 to
20% is good. If the content is less than 0.001%, the effect cannot be expected sufficiently.

The melanin production inhibitor, active oxygen scavenger or cosmetic composition of the present invention is exemplified below, if necessary, in addition to the above-mentioned essential substances, as long as the effects of the present invention are not impaired. It can be manufactured by arbitrarily selecting and using components and additives.

(1) Various fats and oils Avocado oil, almond oil, fennel oil, perilla oil,
Olive oil, orange oil, orange luffer oil, sesame oil, cocoa butter, chamomile oil, carrot oil, cucumber oil, tallow fatty acid, kukui nut oil, safflower oil, shea butter, soybean oil, camellia oil, corn oil, rapeseed oil,
Persic oil, castor oil, cottonseed oil, peanut oil, turtle oil, mink oil, egg yolk oil, palm oil, palm kernel oil, mocro, coconut oil, tallow, lard, or hydrogenated products of these oils (hardened oil, etc.) .

(2) waxes Beeswax, carnauba wax, whale wax, lanolin, liquid lanolin, reduced lanolin, hard lanolin, candelilla wax,
Montan wax, shellac wax, rice wax, squalene, squalane, pristane, etc.

(3) Mineral oil Liquid paraffin, vaseline, paraffin, ozokelide, ceresin, microcrystalline wax and the like.

(4) Fatty acids Natural fatty acids such as lauric acid, myristic acid, palmitic acid, stearic acid, behenic acid, oleic acid, 12-hydroxystearic acid, undecylenic acid, tall oil and lanolin fatty acid, isononanoic acid, caproic acid , 2-ethylbutanoic acid, isopentanoic acid, 2-methylpentanoic acid, 2
-Synthetic fatty acids such as ethylhexanoic acid and isopentanoic acid.

(5) Alcohols Ethanol, isopiranol, lauryl alcohol,
Natural alcohols such as cetanol, stearyl alcohol, oleyl alcohol, lanolin alcohol, cholesterol, and phytosterol, and synthetic alcohols such as 2-hexyldecanol, isostearyl alcohol, and 2-octyldodecanol.

(6) Polyhydric alcohols Ethylene oxide, ethylene glycol, diethylene glycol, triethylene glycol, ethylene glycol monoethyl ether, ethylene glycol monobutyl ether, diethylene glycol monomethyl ether, diethylene glycol monoethyl ether, polyethylene glycol, propylene oxide, propylene glycol , Polypropylene glycol, 1,3-butylene glycol, glycerin, pentaerythritol, sorbitol, mannitol and the like.

(7) Esters Isopropyl myristate, isopropyl palmitate, butyl stearate, hexyl laurate, myristyl myristate, oleyl oleate, decyl oleate, octyl dodecyl myristate, hexyl decyl dimethyloctanoate, cetyl lactate, Myristyl lactate, diethyl phthalate, dibutyl phthalate, lanolin acetate, ethylene glycol monostearate, propylene glycol monostearate, propylene glycol dioleate and the like.

(8) Metal soaps Aluminum stearate, magnesium stearate, zinc stearate, calcium stearate, zinc palmitate, magnesium myristate, zinc laurate, zinc undecylenate and the like.

(9) Gum, saccharide or water-soluble polymer compound Arabic gum, benzoin gum, dammar gum, guaiac oil, Irish moss, karaya gum, tragacanth gum,
Carob gum, quinseed, agar, casein, lactose,
Fructose, sucrose or its ester, trehalose or its derivative, dextrin, gelatin, pectin, starch, carrageenan, carboxymethyl chitin or chitosan, alkylene such as ethylene oxide (C2-C4)
Oxide-added hydroxyalkyl (C2-C
4) chitin or chitosan, low molecular weight chitin or chitosan,
Chitosan salt, sulfated chitin or chitosan, phosphorylated chitin or chitosan, alginic acid or a salt thereof, hyaluronic acid or a salt thereof, chondroitin sulfate or a salt thereof, heparin, ethyl cellulose, methyl cellulose, carboxymethyl cellulose, carboxyethyl cellulose, sodium carboxyethyl cellulose, hydroxyethyl cellulose , Hydroxypropyl cellulose, nitrocellulose, crystalline cellulose, polyvinyl alcohol, polyvinyl methyl ether, polyvinyl pyrrolidone, polyvinyl methacrylate, polyacrylate, polyalkylene oxide such as polyethylene oxide and polypropylene oxide or a crosslinked polymer thereof, carboxyvinyl polymer, Polyethyleneimine and the like.

(10) Surfactant Anionic surfactant (alkyl carboxylate, alkyl sulfonate, alkyl sulfate, alkyl phosphate), cationic surfactant (alkyl amine, alkyl quaternary ammonium salt) ), Amphoteric surfactant:
Carboxylic acid type amphoteric surfactant (amino type, betaine type), sulfate ester type amphoteric surfactant, sulfonic acid type amphoteric surfactant, phosphate ester type amphoteric surfactant, nonionic surfactant (ether type nonionic Surfactants, ether ester type nonionic surfactants, ester type nonionic surfactants, block polymer type nonionic surfactants, nitrogen-containing nonionic surfactants), other surfactants (natural surfactants) , Derivatives of protein hydrolysates,
Polymer surfactants, surfactants containing titanium and silicon,
Fluorocarbon surfactants).

(11) Various vitamins Vitamin A group: retinol, retinal (vitamin A
1), dehydroretinal (vitamin A2), carotene, lycopene (provitamin A), vitamin B group: thiamine hydrochloride, thiamine sulfate (vitamin B1), riboflavin (vitamin B2), pyridoxine (vitamin B)
6), cyanocobalamin (vitamin B12), folic acids,
Nicotinic acids, pantothenic acids, biotins, choline,
Inositols, vitamin C group: ascorbic acid or derivatives thereof, vitamin D group: ergocalciferol (vitamin D2), cholecalciferol (vitamin D
3), dihydrotaxerol, vitamin E group: tocopherol or derivatives thereof, ubiquinones, vitamin K
Group: phytonadione (vitamin K1), menaquinone (vitamin K2), menadione (vitamin K3), menadiol (vitamin K4), other essential fatty acids (vitamin F), carnitine, ferulic acid, γ-oryzanol, orotic acid, vitamin Ps (Rutin, eriocitrin, hesperidin), vitamin U and the like.

(12) Various amino acids Valine, leucine, isoleucine, threonine, methionine, phenylalanine, tryptophan, lysine, glycine, alanine, asparagine, glutamine, serine, cysteine, cystine, tyrosine, proline, hydroxyproline, aspartic acid, glutamic acid , Hydroxylysine, arginine, ornithine, histidine, and the like, and their sulfates, phosphates, nitrates, citrates, and amino acid derivatives such as pyrrolidone carboxylic acid.

(13) Various additives derived from plant or animal raw materials These are processed in a conventional manner according to the type and form of the product to be added (for example, pulverization, milling, washing, hydrolysis, Fermentation, purification, squeezing, extraction, fractionation, filtration, drying, pulverization, granulation, dissolution, sterilization, pH adjustment, deodorization, decolorization, etc. You can choose to serve.

The solvent to be used for the extraction may be selected in consideration of the purpose and type of the product to be provided, the processing to be performed later, and the like. Usually, water and a water-soluble organic solvent (for example, ethanol) are used. ,Propylene glycol,
1, selected from 1,3-butylene glycol)
It is desirable to use a species or a mixture of two or more species. However, when the content of the organic solvent is not preferable depending on the application, only water may be used, or ethanol which is easily removed after the extraction may be used, and may be used alone or in an arbitrary mixed solution with water. Exploited extract may be used.

In addition, additives derived from plant or animal raw materials are
When applied to systemic or topical external preparations and cosmetics, including protection of skin and hair, moisturizing, improvement of feel and texture,
Giving flexibility, relieving irritation, relieving stress by aroma, activating cells (preventing cell aging), suppressing inflammation, improving skin and hair quality, preventing and improving rough skin, hair growth, hair growth, hair loss prevention, gloss Application, cleaning effect, alleviation of fatigue, promotion of blood flow,
In addition to cosmetic effects such as a warm bath effect, effects such as fragrance, deodorization, thickening, preservation, and buffering can be expected.

Specific plants (crude drugs) as raw materials include
For example, almonds (Hentomo), eye (Aiba), Blue Kazura
(Seifu Fuji), Aoki (Aoki), Aokiri or Kenasia Ogiri
(Otogi), Aotsumuraji (Kibo), Acacia, Akashoma (Akashoma), Akasuguri "fruit", Akagrape, Akaminoki (Logwood), Akamegawiwa (Akabu Kashiwa), Akane
(Akane grass root), Acacia elegans or Jiou (Jihuang), Agi (Awei), Akinire (Royu skin), Akebi (Kidori), Asa (John Asako), Malva Asagao or Asagao (Toshiboshi), Hydrangea
(Hydrangea), ashitaba (morning leaves), amana (koujimitsu), azuki
(Red azuki bean), acerola, asenyaku (Asenyaku), anise, abemaki `` fruit '', avocado, ama, amacha (sweet tea), amachaworu, amadocoro (tamatake), amaranth (hiyu,
Balsam pears, Hydrangea, Senninkoku, Sugimorigeito, Hosoaoigaito, Aogaito, Haribiyu,
(Amaranthus hippochondriax), Amigasa lily or frog (shellfish), Altea, Arnica, Alpinia or Katsumadai (Sou-zuku), Aloe (lux), Aloe vera,
Angelica, apricot or Hong apricot (almond jelly), ansokko (benzoic), Igakozorina (biliary head), epimedium or yakima keisou (inyokaku), rush (lantern grass), knotweed (tiger cane root), strawberry (first place), strawberry, Figs (fructose "fruits and leaves"), figs (first), figs
(Aoiko Fuyu), Ichiyakusou (one medicinal herb), Ginkgo (Ginkgo `` seeds, leaves ''), Itohimemegi (Enshi), Carob, Inosumanus (Teirexi), Inuyuyu (Sonagainubiyu), Rice `` seed, seed coat '', Inondo `` seed '' , Ibuki-kusou-so, nettle, ylang-ylang, iwa-tobacco (Iwazuchi-chi), iwahiba or iwamatsu (makikashi), oolong tea, fennel
(Fenka), Ukiyagara (Mitsuryo), Uguisukagura `` fruit '',
Himeuikyo, Turmeric (Utsukin), Duckweed (Floating), Usubasaishin or Keirinsaishin or Shousaisaishin (Spicy), Usvenia oi, Usvenitai oi, Utsubogusa (summer dry grass), Udo or Shishiudo (Qang, Independent, Tang Independent) ), Plum (crow plum `` seed, pulp ''), plum blossom, plum blossom (chrysanthemum), unshu mandarin (chen skin), estragon, elephant grass (Ezo five valley), echina pear (hosobamurasakibarengiku), edoshida, enokitake (bamboo mushroom or ebisugusa), Cassia Tola (Keiko), Elderberry `` fruit '', Elemi, Eryngii or Pre-Lotus Erinji, Enju (Gossip, Gossip rice), Ougi or Kibana-ohgi (Asagi), Ouren (Yoren), Ookarasuri (Karokon) ), Giant horn (civil engineering incense), giant clam (self-defense), giant psyllium (vehicle, car grass), toucan ( Child), Oobanaokera or Atractylodes (Rhizoma Atractylodis Macrocephalae), Obayashi turbocharger busi "fruit", Oomi hawthorn or hawthorn (hawthorn), monarchy
(Naruko Yuri, Kagi Kurumabanaruko Yuri), Ohhisa Sanoyuki or Sasanoyuki, barley (barley), Oohoshigusa
(Cereal sperm), okazeri (snake bed), oguruma (turnover), okra `` fruit '', panax ginseng or ginseng (carrot), hypericum or periwinkle or hypericum perforatum or perforated periwinkle (branch cut grass), dragonfly (interrupted), onamimi Ears), Onigurimi, Onidokoro or Tokoro or Nagadokoro (Hikai), Oninoyagara (Tenma), Oniyuri or Sasayuri or Hakatayuri (Yuri), Ononis, Halibut
(Hihayu), Ominaeshi (losing sauce), Dutch mustard (Watercress), Dutch jelly, Dutch honeywort, olives "fruits, seeds, leaves", oregano, orange "fruits, peels",
Kaikai Soji (ripe yellow), cacao `` fruits, peels, seeds '', oysters (persimmon `` leaves ''), kagikazura (fishing hooks), oysters or kantosou (lotusenso), cassia, casino ), Gajutsu (shajutsu), Kashiwa (shaki, shaba),
Cascarilla, Cascara sagrada, Kanixa (Kin-sato), Valeriana (Kikusone), Birch or Weeping birch (White birch),
Pumpkin, Capokinoki "seed", Kahoku Sansho
(Pepper), cattail (bamboo), chamomile or roman chamomile, chamomile (herbaceous), camucam (duckling), crow squirrel or cinnamon squirrel (flowering meadow), crowsabishak (midsummer), oats mulberry, garana `` seed '', karahoo (thickness) (Pak), Karaya, Karin (Gourd), Garcinia, Kawamidori, Kawara Psycho (Koryosai, Hakubaku), Kawazusha, Kawaratake, Kawaranadeshiko (Ishitake) or Ezokawaranadeshiko (Qumugi, Quumiko), Kawarangin (Aokan), Japanese mulberry (inchinko), kansui (sweet), licorice (licorice), kantarasa, candelilla, kanto, canna, raspberry (ezo strawberry, holland strawberry, shrimp strawberry, nawashiroichigo, maple strawberry, european strawberry), kiwi `` fruit, leaf '', Kikarasuuri (Ururone), Kikyo (Kikyo, Kikyo root), Kiku
(Chrysanthemum, oak, oak), catalpa
(Azumi), Rumex (Yotei root), Pheasant (Kikomi), Kizuta, Kidachi aloe, Kidachiha, Kina, Kinoki (Shincona, Akakinoki), Yellowfin (Huangkashii), Gymnema sylvesta, Cabbage, Cabbage `` Immature fruit '', Cucumber, Gyo-ryu (Nishikawayanagi, Teriyaki), Kiraja Saponaria, Kiraya, Kiranso (Ginseng Herb), Kumquat `` Fruit '', Betel, Kinmizukiki (Sengakuriku), Guava `` Fruit '', Guayule, Quercus Infectria (Gallery), Kukui nuts, wolfberry (Gugi, gugi, gugi leaves, ground skin), cedar quail (Tenmen winter), kudzu (kuzukon), camphor tree, gooseberry `` fruit '', ginseng (yellow flower), gardenia (garashi),
Kunugi (Bokusou), Kumazasa, Kumatsuzura (Erythropogon), Clara (Bittersweet), Cranberry "fruit", Chestnut "seed, fruit,
Astringent skin ", Curculigo latifolia" Fruit ", Grapefruit" Fruit / leaf ", Buckthorn, Black stalk
(Rescue), black crab sprouts or sprouts (prolonged life grass, life prolonged skin), cloves (cloves, cloves), gumbinazuna
(Sekimei, Sekimeishi), Kaigai (Echigaku, Ikeigoho), Keito (Rooster corolla, Chicken copter), Bayberry (laurel), Kenashisarutoribara (Tobukuryo, mountain return), Gentian, Gennoshoko (Old grass), Kemponashi (Kigushi) , Koukisekikoku, Kishumitsukan (Koji, Tachibana, Obenimikan, Fukuromikan, Sagamikouji, Ponkan, Santara (Tachibana skin)), Koshinbara (Monthly flower), Kosuihakka,
Kozo `` fruit '', kohone (river bone), kohon (straw and kara straw), kouriang, kourikyo (takara ginger), cilantro `` fruit '', cucumber (huuanglian), koganebana (yellow gon), lingonberry (koshibachi), Coconut "fruit", Goshyu
(Goshuyu), goshoichigo (covered bonko), pepper (pepper), copaiba balsam, coffee `` seed, leaves '', kobushi or magnolia (spicy), burdock (burdock, burdock), kobotur,
Sesame seeds (sesame), sesame seeds (ginseng), garnish (gomiko), Sanekazura or Binankazura or Matsubusa, wheat (wheat), rice or rice bran “red bran, white bran”, rice oil, cola acuminata “seed”, cola vera "Seed", fenugreek "fruit", colombo, kondurango, kelp, konjac,
Comfrey (final barn grass), sisal (sisal asa), saxima button or syrup
(Sacred Spirits), Sakura (Oshimazakura, Yamazakura, Oyamazakura, Edhigashi, Mamezakura, Miyamazakura,
Yoshino cherry tree, takanezakura, kasumizakura, choujizakura, kohigan, satsakura, kanzakura `` leaves, flowers,
Fruit, bark (cherry bark) ''), cherries, pomegranate, sasa, sasanqua, sagemodaka (sawaka), sweet potato, sugar cane, sugar beet, sun jujube (acid jujube), saffron (red safflower, western safflower), pomelo `` fruit '', Soapwort, salmon berry `` fruit '', Sarashinasho (masuma), salvia (sage), Sawagkyo (Yamakona), Sawagulumi (Yamato), Sansouyouso, Sanshinjin (Sanjin ginseng), Sanshuyu (Yasugyu), Sansho (Sansho), Sandscon (Soybean root), Shea (Karite), Cyano (fruit), Shiitake (Shitake), Shion (Shion), Dikitaris, Shikunshi (Kimiko), Perilla or Aodiso or Chirimenzo or Catamanese (Shiso) (Leaves, perilla), rosewood, linden, Chinese pine, Chinese beetle (forsythia), shimeji (hinshimeji, shakashimeji, hatakeshimeji, oshiroishime) , Bunashimeji, honjimeshi, shirotamogitake), sycamoreus, potato, peonies (shakuyaku), shajin (shasan), janohige (wheat gate), shukushamitsu (sand sand, sand compaction), jujudama, palm `` fruit '', ginger ( Ginger), Japanese hydrangea (Tsuneyama), Shobu (iris, iris root), Shozuku `` fruit '', Shirakashi `` seed '', Shirogoshi butterfly `` seed '', White Azuki bean (chicken bone grass), White iris (Small iris),
Shirobanatsuta `` Flower '', Shirominanten (Tamimi Minami), Cinchonasakusylbra, Jinkoge (Mizuka, Mizuka, Shencho), Cinnamon, Watermelon (watermelon), Honeysuckle (Golden Flower,
Shinobazu), sorrel (acid pattern), swim berry `` fruit '', stevia, strawberry `` fruit '', suzu psycho (Xu Chang Lord), horsetail (Qing Ting), purslane (horse dent, horse tooth kenko), plum `` fruit '', pear Japanese red pine cones, larch, larch, walnuts, hawthorn, dandelion, horse chestnut (malonie),
Pear `` fruits '', snowy pear, elderflower, elderflower, juniper (juniper, juniper), yarrow (milfoil), rose, foliage, mistletoe, mint, or swordfish (Iris), Sekkoku (Ishimasu), Zeniaoi, Hirohase Nega, Senega, Seri, Celery, Sengoku
(Kawa-Kyu), Senshinren (Shinshinren), Sendan, Senburi (Drug), Senna `` fruits and leaves '', Senninsou (Otate),
Souka (grass), buckwheat “seed”, soybean potato, rhubarb
(Ohta), radish, soybean, daidai (orange, kikomi), takasaburo (dry lotus), takatodai (daigei), takawarabi (gull), dark sweet cherry `` fruit '', hollyhock,
Tachijako (Thyme, Hyoka), Tachidokoro (Hikari), Tachiyanagi, Tamarind "seed", Onion, Tamashiba (Spicy), Taranoki "Fruits, leaves, root bark", Tanjin
(Dan ginseng), Dandelion (Gaba Koei) or White dandelion or Moko dandelion, Dammar, Cherry `` fruit '', Chigaya `` fruit, root, bud '', Chikusetsu carrot (Bamboo ginseng), Chicory, Korean ginseng (daihuang), Korean ginseng ( (Wuyi), Ginseng (carrot), Artemisia (Aiba), Choreimaitake (Irei), Tsukimiso, Tsukuritake (Mushroom), Camellia, Camellia, Tsumekusa (lacquer primrose), Tsuyukusa (duckweed grass), Tsuruazuki (Red azuki bean), tsuldokudami (hyoshu crow), tsuruna (ban-an), tsujin carrot (four-leaf ginseng), tsuwabuki, daiko, teuchigurumi, duberry `` fruit '', tengusa, tencha (tencha), tendaiyaku
(Crowd drug), Pepper (Furry gourd), Pepper sparrow, Pepper
(Pan pepper), Touki (Toki), Tokinsenka (Marigold), Tonabena (River cut), Maize or Maize hair (Nanbaru hair), Tomozumomochi (Female Sadako), Toudodo or Korean gooseberry (dragon bile), Tokusa (Wood pirates), dokudami (jujutsu), radish (root spit), red sea bream or mamedaoshi or scutellaria, eucommia (mushroom `` bark, leaves, roots ''), ash (skin), tomato, tragacanth, triacanthos `` seed '', tolmentilla, Dronoki, Trolloa mallow, Niseria berry `` fruit '', potato or yam (yakuyaku),
Naginika (butcher bloom), Naginata Kouju,
Nazuna, oilseed rape, oil bean or sword bean (sword bean), jujube, jujube (daijutsu), nanawaibara (gold cherry blossom), navena
(Intermittent), nameko, narco lily (yellow), peanut (peanut), nanten (minamitenmi), nambangarashi (ramie),
Nigaki (bitter tree), bitter mugwort (bitter), nutmeg, kei or nikkei or ceylon nikkei or yabnikkei (cinnamon bark)
Or Keishi (Keishi), Chinese chive (Nirako), elderberry (bone-bearing tree `` fruit, flower, stem, leaf ''), garlic (garlic), nulde (fivefold child), leek, nemoki or neb or nebi or nemlinoki or zigokubana ( Healing), Nozami (Ohi), Noibara (Fruit), Yarrow, Nodake (Maehu), Nobara, Nomomo,
Palm, pineapple `` fruit '', hibiscus (Bussouge, Furinbussouge, Roselle), Hakamauraboshi (bone crushing), Hakusen (ringworm skin), Huckleberry `` Fruits '', Hakobe (Horuko), Hashibami (Haruko), Hashidokoro
(Roth root), basil, lotus (lotus, lotus, lotus), parsley
(Netherland jelly), naked mussel, batata, bee or medake (bamboo boiled), patchouli, mint (lightly loaded, lightly loaded leaves), barley (yokuinin), hanasuge (chimbo), banana, hana mint, hanabishi (situri, shisuturi), vanilla bins , Papaya, chickweed (mouse koji), hub "whole plant, stem, leaf",
Paprika, Hamago or Mitsuba Hamago (vine thorns), Hamasuge (Kazukiko), Hamabishi (Situriko), Hamanas (Maikai flower), Hamabo Fuu (beach windbreak), Hamamelis, Rose (rose), Haratake (Haratake, Shirooharatake, Usukimori no kasa), Haran, Parietaria, Harunile (yu bark, yu white bark, yuba), hand dai kai (maodai sea), bread tree, giant goose (sun dried), lizard carrot (party party), pecan nut, giganbana (ishiru, ganjusha) (Hana), Hikikoshi (extended life grass, life-extended skin), Hishi (Hisami), pistachio, beet, Aitsuba (stone reed), Aitusa terrestris, Hinata Konouchi (cow knee), Hinoki, Hiba, Castor, Sunflower, Bell pepper, Himeuzu ( (Tenoi), Himegama (incense blossom), Himematsutake (Kawariharatake, Hiromatsutake), Pimenta "fruit", juniper, beakyuu, hiyu "fruit", below Hey, Hiro Ha Okinagusa (Pulsatillae), loquat "fruit, leaves, stems," betel nut (large clothes skin, Biroko), Piper Kadsura (Minamito), butterbur,
Coltsfoot (winter flower, winter leaf), fujibakama (orchid), faba bean (tomato), grape `` fruit, pericarp, seeds, leaves '', beech, beetle, bamboo shoots, brassica, Brazilian carrot, black currant fruit",
Blackberry, plum `` fruit '', furcellaria, blueberry (Prunus avium), prunes, blonde psyllium, bundou (green beans), loofah, safflower (safflower),
Henneken, belladonna, berry `` fruit '', Peruvian bergen, beetwort or duckweed (Keiten), boysenberry `` fruit '', duckweed or elderweed or nendowe or haeukigi kokia (terrestrial), daffodil (horizon, acute child,
Osteoporotic grass), boufu (windbreak), spinach, physalis (Torone), honoki (Japanese magnolia, magnolia), bokeh (mochi), shirobanaokera (sojutsu), shiroboshikirinsou (Shinjing Sangei), shiroboshi renjiku, bodaiju (Bodice tree), button (peony, peony bark), hop, jojoba, white berry `` fruit '', hon-oniku (meat porcelain, large art), hon-sekko (iron bark stone,
Sparrow mountain stone), misurutennanshaw (tennanboshi), maitake (maitake), ephedra (mao), macadamia nuts, macri
(Sea grass), maguwa (mulberry white bark `` bark, leaf ''), magnolia or splengeri, matatabi (kiten tate), matsukasa, pine `` leaf, bark, root '', matsuhodo (bukuryo), mayolam (Hanahakka), Malvanojazine (Bitterfruit), Mulberry `` Fruit '', Quince, Mango, Mangosteen, Manshu Gurumi, Mandarin `` Fruit '', Mannentake (Lingzhi), Pheasant (Kikimi `` Fruit ''), Mishima Psycho (Saiko), Mizuobako or Mizuasagao (Dragon) Tongue grass), mizokokushi (half lotus), misohagi (senkakuna), beetle or elder willow (edition), honeywort, honeywort, green peppermint, mimosa, mioka,
Miracle fruit `` Fruit '', Myrrh, Myrobaran, Mukuge (Mokuge), Mukunoki, Mukuroji, Murasaki (purple root), Murasakisikibu or Omurasashikibu (purple), Murasaki maize, Murasaki nutfuji (Kumming chicken blood Fuji), Mehajiki
(Mother mother grass), Mebogi, Melaleuca, Melissa, Meliloth, Melon `` Fruit '', Moukomugi, Mosouchikku, Mokko (wood incense), Maple blossom, Peach (peach `` leaves, seeds, flowers, fruits ''), bean sprouts, morello cherry fruit",
Moroheiya (burlap), yakawamurasakiimo, yakuchi (masuchi), cornflower (cornflower), cornflower mint,
Yashabushi (arrow wheel) or Himeyashabushi or Obayashishabushi `` fruit, peel, kaho '', yachiyanagi, yatsude (octagonal metal plate), mistletoe (willow parasitism), willow (kawayanagi, tachinyanagi, weeping willow, akameyanagi, nekoyanagi, inukiyanagi, okinoyagi, oak Unryu willow, yamayama willow, yamayanagi, obyan willow, tyric willow willow, foxwood willow, dronoki), willow leaf `` leaves and stems '', yabugarashi, yabukouji (purple gold cow), yabu tobacco (tsuruisuri, tenmeisei), yamagobo han (land)
(Yamaharu), Bayberry (Plum skin), Bayberry, Eucalyptus,
Saxifraga (tiger ear grass), yucca or flevifolia, yuzu "fruit", lily, yogurusa, mugwort (autumn leaf), reigan
(Rainuma), lime `` fruit '', rye, lacanca `` fruit '', raspberry `` leaves, fruit '', latania (clameria), raccoon or shallot (scallop), lavender, longan (long-eye meat), agave ), Apple "fruits, seeds, leaves, roots", gentian, rubus or suavisimus (sweeten), litchi (lichi, lichi nucleus), lettuce (chisha), red currant "fruit", lemon "fruit", lemongrass , Forsythia or Chinese forsythia (forsythia), astragalus, coconut palm, locust (reed), loganberry "fruit", rosemary (mannen wax), rose hip
(Nobara), wasabi, warmoko (jiyu) and the like.

Other seawater, for example, seawater salt, dried seawater, inorganic salts obtained from the Dead Sea or the Atlantic or Pacific Ocean (sodium chloride, magnesium chloride, potassium chloride, etc.), sea mud or mud (fango) Species, for example, sea mud or mud of various places such as Italian Fango, German Fango, Eifel Fango, Freiburg Fango, etc. (Ingredients:
Silicon dioxide, titanium dioxide, aluminum oxide, iron oxide, manganese oxide, sodium oxide, potassium oxide, magnesium oxide, calcium oxide, strontium oxide, sodium, potassium, magnesium, calcium, chromium, iron, copper, nickel, zinc, lead, manganese,
Arsenic, water).

Examples of the seaweeds include seaweeds [green algae: Chlorella vulgaris, Chlorella pyrenoidosa, Chlorella ellipsoidia, Aonori (Usubaaonori, Susiaonori, Hiraaonori, Bouaonori, Hosoedaoonori)], and seaweed [brown algae: brown algae: Kombu alga; , Resilicon b, hosomekobu, mishitoshibu), seaweed, hirome, blue seaweed, giant kelp (macrocystis pilifera, macrocystis integrifolia, neocitys luetokeana), hijiki, hibamata), seaweed [red alga: hijirimen, maxa ( Tengsa),
Hirakusa, Omikusa, Obakusa, Katao Bakusa, Yatabegusa, Yuikiri, Shimanegusa, Tosakanori, Togekirinsai, Akumasakirinsai, Kirinsai, Zyakushinkirinsai, Tsunomata, Obatsunomata, Tochaka , Ibotsunomata, Yaleus Banori, Kagius Banori,
Suzius Banori, Hyus Banori, Akamomininori] and the like.

Other algae such as green algae (Chlamydomonas spp .: Chlamydomonas spp., Akayukimo, Dunaliella spp .: Dunaliella spp., Chlorococcus spp .: Chlorococcus, Kwanomimo spp .: Kwanomimo spp., Volvox spp. Spirogyra: Hizaori, Spirogyra, Tulsimidro, Hibimidro: Hibimidoro, Aosa: Anaoasa, Amiosa, Nagaosa, Kawanori: Kawanori,
Genus Fricciella, genus genus: medusa, asiaticum gutta, kawashiogusa, marimo, baronia: tamagobaronia, tamabaronia, tamagata: tamagatamo, iwata: husaiwata, surichogita, heraiwata, kurokita, kurokita, kurokita Sakibuchimil, Nagamir, Hiramil, and Casanori:
Casanori, Jusmo: Fusuzumo, Tamazumi,
Species of the genus Mizudzumo, Genus Genus, Genus Colecaet, Genus Genus genus, Species of the genus Cyperaceae: Species of the genus Cyperaceae, the genus of the spider genus;

Blue-green algae (Genus Lynchium: L., L., L., L .;
(Hassay, Yuremo, Racenmo (Spirulina) genus: Spirulina, Trichodesmium (Aiakashio), etc.).

Brown algae (Piraella spp .: Piraella spp., Shiomidoro spp .: Naganami spp., Isogrape spp .: Isogrape,
Genus Isogawara: Isogawara, Kuroshira Genus: Gunsenkurogashira, Kashirazaki Genus: Kashirazaki, Muchimo Genus: Muchimo, Hiramutimo, Kebelligsa, Amidixa Genus: Amidigsa, Sakibiroamiji, Sanadagusa: Sanadagusa, Fukurinamiji, Common Genus Artemisia spp.
Genus genus: genus pine, genus genus: genus genus: genus genus, genus okinawa, genus okinawazuku, genus phlebosum, genus phlebosum, genus phlebosum: genus futomozuku, genus genus moss: genus genus: genus kuromo, genus moss, genus genus Ishige, Irolo, Icmegasa: Icmegasa, Keyari: Keyari, Umibos: Umibos, Urushigusa: Urushigusa,
Betula serrata, Tobacco moss, Laminaria spp. Genus Kagomenori: Kagomenori, Muraridori: Murachidori, Shakusugusa: Sharks
Genus Genus: Genus Genus, Genus Genus: Genus Genus: Genus Genus, Genus Kayamonori, Genus Genus: Genus Genus: Genus Filiformis, Genus Turmo: Genus Tsurumo, Genus Anana: Genus Anastasia, Genus Suzume: Genus Musicum, Genus Missiscoma, Genus L. , Oni-kombu, Gohei-kombu, Naga-kombu, Pea-kombu, Ochimitsu-kombu, Toro-kombu genus: Toro-kombu, Antokume genus: Antokume, Kajime genus: Kajime, Tsuruarame, Kurome, Kikuishicombu genus: Kikuishikombu, Nejirekombu: Nekorecome genus, Kuroshimae : Nekoshikonbu,
Alame: Alame, Ainuwakame: Ainuwakame, Chigaiso, Oniwakameezoishige: Ezoishige, Yabanemoku: Yanemoku, Rapamoku: Rapamoku, Jiromoku: Uganomok, Jiromoku, Hiemomoku, Hokumoku, Tamamomoku, Tamamomoku Akamoku, Shidamoku, Hondawara, Nejimoku, Narasamo, Mametarawara, Tatsukuri, Yasumatamoku, Umitrano, Oobamoku, Fushizushimoku, Hahakimoku, Togemoku, Jolemoku, Saw-moku, Obanoki-mimoku, Genus genus:
Bulukimo, genus cynomolgus: cynomolgus etc.).

Red algae (Russia genus: Ushikenori, Funorinoushike, Amanori: Asakusanori, Susabinori,
Genus Upirinori, Onimanori, Tasa, Filitasa, Benitasa, Rhodocorton: Milnoveni, Akebonomozuku: Akebonomozuku, Konahada: Haikonahada, Yogorekonahada, Aokonahada, Sea Species: Acer genus, Acer genus : Larch, Fusanori: Fusanori, Nisefusanori: Nisefusanori,
Sodegarami: Sodegarami, rattles: rattle, rattle rattle, hirohatamatamaki genus: hirohatamaitadaki, tamamaidaki genus: tamaitadaki, kagikenori genus: kaginori, kakenenori, tengusa: himetenugosa, haitenugosa, haitenugosa, haitenugusaugou, haitenuganugou, haitenuganugou, haitenugusaugou Genus: hibiroudo, himehibiroudo,
Genus Isommedogi: Genus Isomomedo, Genus genus: Genus medusa, Ryumonsou: Ryumonsou, Hera Ryumon, Nisekarekususa: Genus Nisekaregusa, Okitsubara: Obaokitsubara, Akaba: Akaba, Malvaacaba, Naminohana genus
Naminohana, coral genus: rattle, mushroom, shiogosagoromo, iwanokawa: ezukiiwanokawa, kainokawa: kainokawa, kaninote: kaninote, coral genus: coral, coral, mosquito mosquito , Tambanori, slippery,
Genus Isonohana: Nuracusa, Cronulla, Stinging genus, Hirakintoki: Hirakintoki, Matagawa: Matabou, Kintoki: Chabokintoki, Kintoki, Matsunori, Komenori, Tosakamatsu, Aedes pine, Kakraitus: Genus Odonata, Genus Larva Genus Nagaobane, Funori: Hanafunori, Fukuronori, Makuhnori, Karenikusa: Kalexigusa, Tosakamomoki: Hosobanotokamodoki, Hirohanotosakamakiki, Yatsudegatomodoka, Kurosakacamodoki, Nezashinodoka, Nezashinotokada : Ezotosaka, Tsukasanori: Enashikarimenia, Otsukasanori, Hanagatakarimenia, Honooka: Hounoo, Hikagenoito: Hikagenoito, Usuginu, Nikuhono: Nikuho Noo, Benisunago genera: Benisunago, Susukakebeni genera: Susukakebeni, Okamuragusa genera:
Yamadakusa, Mirin genus: Mirin, Hosobamilin, Tosakanori genus: Kikutosaka, Ezonameshi: Ezonameshi, Isomokka genus: Isomocca, Yukari genus: Yukari, Hosoyukari, Ibaranori genus: Ibaranori, Saidaibara, Tachiibara, Kagiibanodan, Kijinotho genus Isanthus, Atsubanori: Atsubanori,
Ogonori: Ogonori, Tsurushiramo, Shiramo, Ogogonori, Mizookonori, Kabanori, Tengusamodoki: Hachijotengusamodoki, Fushikrenori: Fushikenori, Namiiwatake: Namiiwatake, Spiraea:
Sponge and genus: ssp.
Genus: crocodile, crocodile, crocodile, lotus spp .: lotus spp. The genus Taogosou: Taoyanagisou, Hanasakura, Shirotsunagi: Skullconi, Shikokonori, Hananoeda: Hanaeda, Hiratagoat: Hiratagoat, Darusu: Dars, Masagoshibari, Anadars, Weedbugsa: Uebaguni, Benifukunori
Species of sarcophagi: sarcophagia, scorpion, scorpion, scorpion genus: syllabus, smelt, ssp. Family: Habutaenori, Konohanori, Suzushironori, Usbeni genus: Usbeni, Hasuginu: Hasujiginu, Nagakonohanori: Nagakonohanori, Suzuginu: Suzuginu, Abasibaginu, Hyusbanori: Kagusubanori, Jauresubanoli, Jaureusubanoli, Jaureusubanori, Jaureusubanoli
Genus Ayanishi: Genus Ayanishi, Genus Ayaginu: Genus Ayaginu, Genus Dassia: Enashidazia, Genus Shimadagi: Genus Isohagi, Genus Shimadada, Genus Dazimodoki: Genus Dazimomodoki, Genus Itogusa: Moletogusa, Genus Genus: Makuri, Yanagina, Hana, Rana Salix var. Genus Isomegusa: Isomegusa, Suginashigusa: Suginashigusa, Isobashigenus: Isobashi, Fujimatsumo Genus: Fujimatsumo, Sawwort: Mushroom Rihiba, Kawamozuku genera: Kawamozuku, Aokawamozuku, Himekawamozuku, Ideyukogome genera: Ideyukogome, Okichimozuku genera: Okichimozuku,
Genus genus, genus chinorimo: chinorimo, genus thysinori: chisinori).

Wheel algae (Charus spider, Shiratamamo,
L. genus: L., Lychnotanus, L. genus: L., L., etc., Yellow algae (L. genus: L.).

Materials derived from animal raw materials include a cockscomb extract, a cow or human placenta extract, a pig or cow extract from the stomach, duodenum, or intestine or a decomposition product thereof, and a pig or cow spleen extract. Product or its degradation product, extract of pig or cow brain tissue, water-soluble collagen, collagen derivative such as acylated collagen, collagen hydrolyzate, elastin, elastin hydrolyzate, water-soluble elastin derivative, keratin and its decomposition product Or a derivative thereof, a silk protein and its degradation product or a derivative thereof, a pig or bovine blood cell protein degradation product (globin peptide), a pig or bovine hemoglobin degradation product (hemin, hematin, heme, protohem, heme iron, etc.),
Cow milk, casein and its decomposition products or their derivatives, skim milk powder and its decomposition products or their derivatives, lactoferrin or its decomposition products, chicken egg components, fish meat decomposition products and the like.

(14) Microbial culture metabolite Yeast metabolite, yeast extract, natto metabolite, natto extract, rice ferment extract, rice bran ferment extract, euglena extract, lactic acid fermentation product of raw milk or skim milk powder and trehalose Or a derivative thereof.

(15) α-hydroxy acids Glycolic acid, citric acid, malic acid, tartaric acid, lactic acid and the like.

(16) Inorganic pigment: anhydrous silicic acid, magnesium silicate, talc, kaolin,
Bentonite, mica, titanium mica, bismuth oxychloride, zirconium oxide, magnesium oxide, zinc oxide,
Titanium oxide, calcium carbonate, magnesium carbonate, yellow iron oxide, red iron oxide, black iron oxide, gunjou, chromium oxide,
Chromium hydroxide, carbon black, calamine, etc.

(17) UV absorber / blocker Benzophenone derivatives (2-hydroxy-4-methoxybenzophenone, 2-hydroxy-4-methoxybenzophenone-5-sulfonic acid, 2-hydroxy-4-methoxybenzophenone-5-sulfonic acid Sodium, dihydroxydimethoxybenzophenone, sodium dihydroxydimethoxybenzophenone-sulfonate, 2,4
-Dihydroxybenzophenone, tetrahydroxybenzophenone, etc.), p-aminobenzoic acid derivatives (such as paraaminobenzoic acid, ethyl paraaminobenzoate, glyceryl paraaminobenzoate, amyl paradimethylaminobenzoate, octyl paradimethylaminobenzoate), methoxycinnamic acid Derivatives (ethyl paramethoxycinnamate, isopropyl paramethoxycinnamate, octyl paramethoxycinnamate, 2-ethoxyethyl paramethoxycinnamate, sodium paramethoxycinnamate, potassium paramethoxycinnamate,
Diparamethoxycinnamate mono-2-ethylhexanoate glyceryl, etc.), salicylic acid derivatives (octyl salicylate, salicylphenyl, homomenthyl salicylate, dipropylene glycol salicylate, ethylene glycol salicylate, myristyl salicylate, methyl salicylate, etc.), anthranilic acid derivatives (methyl anthranilate) Urocanic acid derivatives (such as urocanic acid and ethyl urocanate), coumarin derivatives, amino acid compounds,
Benzotriazole derivatives, tetrazole derivatives, imidazoline derivatives, pyrimidine derivatives, dioxane derivatives, camphor derivatives, furan derivatives, pyrone derivatives,
Nucleic acid derivatives, allantoin derivatives, nicotinic acid derivatives,
Vitamin B6 derivatives, umbelliferone, esculin,
Benzyl cinnamate, sinoxate, oxybenzone, dioxybenzone, octabenzone, slisobenzone, benzoresorcinol, arbutin, guaiazulene, shikonin, baicalin, baicalein, berberine, neoheliopan, escalol, zinc oxide, talc, kaolin.

(18) Whitening agent p-aminobenzoic acid derivative, salicylic acid derivative, anthranilic acid derivative, coumarin derivative, amino acid compound,
Benzotriazole derivatives, tetrazole derivatives, imidazoline derivatives, pyrimidine derivatives, dioxane derivatives, camphor derivatives, furan derivatives, pyrone derivatives,
Nucleic acid derivatives, allantoin derivatives, nicotinic acid derivatives,
Vitamin C or a derivative thereof, vitamin E or a derivative thereof, oxybenzone, benzophenone, arbutin, guaiazulene, shikonin, baicalin, baicalein,
Berberine, placenta extract, etc.

(19) Tyrosinase activity inhibitor Vitamin C acid or its derivative, hydroquinone or its derivative (hydroquinone benzyl ether), kojic acid or its derivative, vitamin E or its derivative, N-acetyltyrosine or its derivative, glutathione, Hydrogen oxide, zinc peroxide, hydroquinone monobenzyl ether, placenta extract, silk extract, plant extract (mulberry, touki, warmoko, clara, mugwort, honeysuckle, yellowfin, dokudami, matsuhodo, barley, hydrangea, hops, hawthorn, Eucalyptus, Yarrow, Altea, Keihi, Mankeishi, Hamamelis, Yamaguwa,
Prolonged life grass, bellflower, toshishi, spermatozoa, sun dried, mahuang, senkyu, dokkatsu, psycho, bohu, hamabofu, ougon, peony skin, peonies, genoshoko, kakkon, licorice, five times child, aloe, shoma, safflower, green tea, tea, Asenyaku).

(20) Melanin pigment reduction / decomposition substance Phenylmercury hexachlorophene, mercuric oxide, mercurous chloride, aqueous hydrogen peroxide, zinc peroxide, hydroquinone or a derivative thereof (hydroquinone benzyl ether) and the like.

(21) Turnover promoting action / cell activator hydroquinone, lactic acid bacteria extract, placenta extract, reishi extract, vitamin A, vitamin E, allantoin, spleen extract, thymus extract, yeast extract, fermented milk extract, plant extract (Aloe, Ogon, Horsetail, Gentian, Burdock,
Sicon, carrot, hamamelis, hop, yokunin,
Odorikosou, Assemblage, Touki, Tokinsenka, Amacha, Hypericum, Cucumber, Periwinkle,
Rosemary, parsley).

(22) Astringent succinic acid, allantoin, zinc chloride, zinc sulfate, zinc oxide, calamine, zinc p-phenolsulfonate, aluminum potassium sulfate, resorcinol, ferric chloride, tannic acid (including catechin compound) Such.

(23) Active oxygen scavenger SOD, catalase, glutathione peroxidase and the like.

(24) Antioxidant Vitamin C acid or its salt, stearic acid ester, vitamin E or its derivative, nordihydroguaseletenic acid,
Butylhydroxytoluene (BHT), butylhydroxyanisole (BHA), hydroxytyrosol, parahydroxyanisole, propyl gallate, sesamol, sesamolin, gossypol and the like.

(25) Lipid peroxide production inhibitor β-carotene, plant extract (cultured sesame cells, amateur,
Hypericum, Hamamelis, Clove, Melissa, Emmeso, Birch, Sage, Rosemary, Minami Tenmi,
Ages, ginkgo, green tea) etc.

(26) Anti-inflammatory agent Ictamole, indomethacin, kaolin, salicylic acid, sodium salicylate, methyl salicylate, acetylsalicylic acid, diphenhydramine hydrochloride, d-camphor, dl-camphor, hydrocortisone, guaiazulene, camazulene, chlorpheniramine maleate, glycyrrhizin Acid or a salt thereof, glycyrrhetinic acid or a salt thereof, licorice extract, sicon extract, age extract and the like.

(27) Antibacterial, bactericidal and disinfecting agents acrinol, sulfur, calcium gluconate, chlorhexidine gluconate, sulfamine, mercurochrome, lactoferrin or a hydrolyzate thereof, alkyl diaminoethyl glycine chloride solution, triclosan, sodium hypochlorite, Chloramine T, salad powder, iodine compound,
Iodoform, sorbic acid or a salt thereof, salicylic acid, dehydroacetic acid, parahydroxybenzoic acid esters, undecylenic acid, thiamine lauryl sulfate, thiamine lauryl nitrate, phenol, cresol, p-chlorophenol, p-chloro-m-xylenol, p-chloro-m
-Cresol, thymol, phenethyl alcohol, o-
Phenylphenol, Irgasan CH3565, halocarban, hexachlorophen, chlorohexidine, ethanol, methanol, isopropyl alcohol, benzyl alcohol, ethylene glycol, propylene glycol, phenoxyethanol, chlorobutanol, isopropylmethylphenol, nonionic surfactant (polyoxyethylene lauryl ether , Polyoxyethylene nonyl phenyl ether, polyoxyethylene octyl phenyl ether, etc.), amphoteric surfactants, anionic surfactants (sodium lauryl sulfate, lauroyl sarcosine potassium, etc.), cationic surfactants (cetyltrimethylammonium bromide, benza chloride) Ruconium, benzethonium chloride, methylrosaniline chloride), formaldehyde, hexamine, Reliant Green, Malachite Green, Crystal Violet, Jarmal, Photosensitizer No. 101, Photosensitizer No. 201, Photosensitizer No. 401, N-long-chain acyl basic amino acid derivatives and their acid addition salts, zinc oxide, hinokitiol, kudin and the like.

(28) Humidifier Glycerin, propylene glycol, 1,3-butylene glycol, hyaluronic acid or a salt thereof, polyethylene glycol, chondroitin sulfate or a salt thereof, water-soluble chitin or chitosan derivative, pyrrolidone carboxylic acid or a salt thereof, lactic acid Sodium, Mini Sasanishiki extract, Bacillus natto metabolite, Natto extract, etc.

(29) Inhibitors of elastase activity diisopropyl fluorophosphate, plant extracts (Ougon, Hypericum perforatum, Clara, mulberry leaves, calyx, gennoshoko, comfrey, sage, elderberry, bollige, buttonpig), seaweed extracts and the like.

(30) Hair preparations Selenium disulfide, alkylisoquinolinium bromide solution, zinc pyrithione, biphenamine, thianthol, castal tincture, ginger tincture, capsicum tincture, quinine hydrochloride, strong aqueous ammonia, potassium bromate, bromate Sodium, thioglycolic acid and the like.

(31) Antiandrogens Estrogen (estrone, estradiol, ethinylestradiol, etc.), isoflavones, oxendrones and the like.

(32) Peripheral vascular blood flow promoter Vitamin E or a derivative thereof, assembly extract, garlic extract, carrot extract, aloe extract, gentian extract, touki extract, cepharanthin, carpronium chloride, minoxidil and the like.

(33) Topical stimulants Pepper tincture, nonylate vanillamide, cantaris tincture, ginger tincture, peppermint oil, l-menthol, camphor, benzyl nicotinate and the like.

(34) Metabolic activators Photosensitizer No. 301, hinokitiol, pantothenic acid or derivatives thereof, allantoin, placental extract, biotin, glyceride pentadecanoate and the like.

(35) Antiseborrheic agents pyridoxine or its derivatives, sulfur, vitamin B6 and the like.

(36) Keratolytic agent Resorcin, salicylic acid, lactic acid and the like.

(37) Oxidizing agent Hydrogen peroxide solution, sodium persulfate, ammonium persulfate, sodium perborate, urea peroxide, sodium percarbonate, sodium tripolyphosphate, sodium bromate, potassium bromate, pyrroline peroxide Sodium acid, sodium orthophosphate, sodium silicate hydrogen peroxide adduct, sodium sulfate sodium chloride hydrogen peroxide adduct, β-tyrosinase enzyme solution, mushroom extract and the like.

(38) Hair remover Strontium sulfate, sodium sulfide, barium sulfide,
Inorganic reducing agents such as calcium sulfide; thioglycolic acid or salts thereof (calcium thioglycolate, sodium thioglycolate, lithium thioglycolate, magnesium thioglycolate, strontium thioglycolate) and the like.

(39) Hair swelling agent Ethanolamine, urea, guanidine and the like.

(40) Dyes 5-aminoorthocresol, 2-amino-4-nitrophenol, 2-amino-5-nitrophenol, 1-
Amino-4-methylaminoanthraquinone, 3,3'-
Iminodiphenol, 2,4-diaminophenoxyethanol hydrochloride, 2,4-diaminophenol hydrochloride, toluene-2,5-diamine hydrochloride, nitroparaphenylenediamine hydrochloride, paraphenylenediamine hydrochloride, N-phenylparaphenylenediamine hydrochloride, meta-hydrochloride Phenylenediamine, orthoaminophenol, N-phenylparaphenylenediamine acetate, 1,4-diaminoanthraquinone, 2,6-diaminopyridine, 1,5-dihydroxynaphthalene, toluene-2,5-diamine, toluene
3,4-diamine, nitroparaphenylenediamine, paraaminophenol, paranitroorthophenylenediamine, paraphenylenediamine, paramethylaminophenol, picramic acid, sodium piclaminate, N,
N'-bis (4-aminophenyl) -2,5-diamino-1,4-quinonediimine, 5- (2-hydroxyethylamino) -2-methylphenol, N-phenylparaphenylenediamine, metaaminophenol, meta Phenylenediamine, 5-aminoorthocresol sulfate, 2-amino-5-nitrophenol sulfate, orthoaminophenol sulfate, orthochloroparaphenylenediamine sulfate, 4,4'-diaminodiphenylamine sulfate, 2,4-diaminophenol sulfate, sulfuric acid Toluene-2,5-
Diamine, nitroparaphenylenediamine sulfate, paraaminophenol sulfate, paranitroorthophenylenediamine sulfate, paranitrometaphenylenediamine sulfate, paraphenylenediamine sulfate, paramethylaminophenol sulfate, metaaminophenol sulfate, metaphenylenediamine sulfate, catechol, diphenylamine , Α-naphthol, hydroquinone, pyrogallol, phloroglucin, gallic acid, resorcin, tannic acid, 2-hydroxy-5-nitro-2 ', 4'-diaminoazobenzene-
Sodium 5'-sulfonate, hematein and the like.

(41) Flavors Natural animal flavors such as musk, civet, castorium, ambergris, anise essential oil, angelica essential oil, ylang-ylang essential oil, iris essential oil, fennel essential oil, orange essential oil, cananga essential oil, caraway essential oil, cardamom essential oil, Guaiac wood essential oil, cumin essential oil, black letter essential oil, cinnamon essential oil, cinnamon essential oil, geranium essential oil, copaiba balsam essential oil, coriandel essential oil, perilla essential oil, cedar wood essential oil, citronella essential oil, ginger grass essential oil, cedar essential oil, spearmint essential oil, western peppermint essential oil, Great Fengxiang essential oil, Tuberose essential oil, T-shaped essential oil, orange flower essential oil, winter green essential oil, Trobal sam essential oil, baturi essential oil, rose essential oil,
Palmarosa essential oil, Cypress essential oil, Hiba essential oil, Sandalwood essential oil, Petitgren essential oil, Bay essential oil, Vetiba essential oil, Bergamot essential oil, Peruvian balsam essential oil, Boad rose essential oil, sycamore essential oil, Mandarin essential oil, Eucalyptus essential oil, Lime essential oil, Lavender essential oil, Linaloe essential oil, Plant flavors such as lemongrass essential oil, lemon essential oil, rosemary essential oil, Japanese peppermint essential oil, and other synthetic flavors.

(42) Dyes / Colorants Red cabbage dye, red rice dye, madder dye, anato dye, squid dye, turmeric dye, orange dye, krill dye, persimmon dye, caramel, gold, silver, gardenia dye, corn dye , Onion pigment, tamarind pigment, spirulina pigment, buckwheat whole plant pigment, cherry pigment, laver pigment, hibiscus pigment, grape juice pigment, marigold pigment, purple potato pigment, purple yam pigment, lac pigment, rutin, etc.

Other hormones, sequestering agents,
pH adjuster, chelating agent, antiseptic / antibiostatic agent, cooling agent, stabilizer, emulsifier, animal / vegetable protein or its degradation product, animal / vegetable polysaccharide or its degradation product, animal / vegetable glycoprotein or Decomposed products, anti-inflammatory and anti-allergic agents, wound treatment agents,
Bubble / foaming agents, thickeners, oral agents, deodorants / deodorants, bittering agents, seasonings, enzymes, etc. are expected to be added, and combined or synergistic effects can be expected. it can.

The form of the melanin production inhibitor, active oxygen scavenger or cosmetic composition of the present invention is arbitrary, and may be capsules, powders, granules, solids, liquids, gels, bubbles, emulsions, creams, ointments. , Sheets and the like.

Specifically, for example, topical preparations for external use, lotions, emulsions, creams, ointments, lotions, oils, packs, and other basic cosmetics, facial cleansers and skin cleansers, depilatory agents, depilatory agents, aftershave lotions , Pre-show lotion, shaving cream, shampoo, rinse,
Hair treatments, hair styling agents, perm agents, hair tonics, hair dyes, hair growth / hair restorations, etc., makeup cosmetics such as foundations, lipsticks, blushers, eye shadows, eyeliners, mascaras, perfumes, bath agents , Other, toothpaste, mouth freshener / gargle, deodorant,
It can be applied to various products such as deodorant, sanitary cotton, wet tissue, and can be used for general food and drink.

The method of adding to the melanin production inhibitor, active oxygen scavenger or cosmetic composition of the present invention may be added in advance or during the production.
What is necessary is just to select suitably in consideration of workability.

[0078]

EXAMPLES The present invention will be described below with reference to production examples, test examples, and prescription examples, but the present invention is not limited to these examples.

(Production Example 1) Jasmine, Banaba, Uba,
Each 100 g of each plant of Pu'er is heated and extracted with purified water (about 80 ° C) for about 5 hours, filtered, and the extract (dry solids:
About 0.3-2.5% by weight).

(Production Example 2) Jasmine, Banaba, Uba,
100 g of each of the Puer plants is immersed in a 50% ethanol solution, extracted at room temperature for 5 days and night, and then filtered to obtain about 1.0 kg of an extract (dry solid content: about 0.3 to 2.5% by weight).

(Production Example 3) Jasmine, Banaba, Uba,
100 g of each plant of Pu'er is immersed in 70% ethanol solution or 30% 1,3-butylene glycol solution, or 60% propylene glycol solution, or purified water (about 30 ° C),
After extraction at room temperature for 5 days and nights, the mixture is filtered to obtain about 1.0 kg of an extract (dry solid content: about 0.3 to 3.0% by weight).

(Test 1) Melanin production inhibitory test The present inventor evaluated melanin production inhibitory activity based on B16 melanoma cells.

[Test Method and Evaluation Method] B16 melanoma cells pre-cultured for 24 hours were transferred to a fresh medium, and a sample was added to the medium for 0.5 hour.
% And culture for 3 days. Next, the cultured cells are treated with trypsin, dissolved by heating in a 1N-NaOH, 10% DMSO solution, and the absorbance at 420 nm is measured. In addition, instead of the sample, distilled water was used as a blank, and cells to which the sample was added at the same time were subjected to the MTT reduction method (Tim Mosmann; Journal
f Immunological Methods p55-63 (1983)), the activity was measured, and the MTT reducing activity of the sample-loaded cells was calculated using the MTT reducing activity of the blank cells as one unit. The amount of melanin in the sample was calculated as absorbance / MTT reduction activity (1 unit), and the inhibition rate (%) of the blank cells against the amount of melanin production was determined by Equation 1. The results are shown in FIG. "Sample" As a sample for the melanin production inhibitory action test, the extract (solid content concentration: adjusted to 0.5%) obtained in Production Example 2 of the present invention was used for the test. As a comparative sample, arbutin (manufactured by Sigma) was prepared under the same conditions and used for the test.

<Equation 1> Melanin production inhibition rate (%) = ｛1− (melanin amount of sample /
Blank melanin amount)｝ × 100

(Test Results) As shown in FIG. 1, it was confirmed that the jasmine, banaba, uba, and puer plant extracts of the present invention significantly suppressed the production of melanin pigment and had a high melanin production inhibitory action. Was. In addition, it has been confirmed that they have almost the same or higher melanin production inhibitory action than arbutin, and can be used as a whitening agent.

(Test 2) Elimination of active oxygen (SOD-like activity)
Action Test In recent years, many diseases and diseases induced by active oxygen have been reported, and it has been pointed out that removal / elimination of active oxygen (SOD activity) leads to prevention of tissue damage. In this test, the extract obtained in Production Example 2 was tested for its ability to eliminate active oxygen generated by the xanthine-xanthine oxidase system using the NBT method of the Imana et al. (Co., Ltd.).

[Test Method and Evaluation Method]
2.5 mL of M sodium carbonate buffer (pH 10.2), 0.75 mM nitro blue tetrazolium (NBT), 3.0 mM xanthine, 3.0 mM disodium ethylenediaminetetraacetate, 0.15 W
/ V% bovine serum albumin and 0.1 mL each of a sample solution (the solvent for the control) were added, and the mixture was kept at 25 ° C. for 10 minutes.
0.1 mL was added, and the absorbance at 560 nm was measured. In addition, a sample containing purified water instead of a sample was used as a control. For each sample and control, a blank containing a reaction stop solution was set before adding xanthine oxidase. I asked. The results are shown in FIG. "Sample" The sample of the active oxygen scavenging action test was the extract obtained in Production Example 2 of the present invention (adjusted to a solid content of 0.01%).
Was used for the test. As a comparative sample, Eucommia extract (manufactured by Ichimaru Falcos) was prepared under the same conditions,
Used for testing.

<Equation 2> Active oxygen elimination rate (%) = {1− (sample OD value−flank (sample) OD value) / (illumination OD value−flank (control) OD value)} × 10
0

(Test Results) As shown in FIG. 2, it was confirmed that the plant extracts of jasmine, banaba, uba, and puer of the present invention significantly suppressed the production of active oxygen and had a high active oxygen scavenging effect. . Further, it has been confirmed that the active oxygen scavenger has a higher active oxygen scavenging effect than that of Eucommia, and can be used as an active oxygen scavenger.

(Test 3) Safety test (1) Primary skin irritation test Various plant extracts obtained in Production Examples 1 to 3 were prepared in purified water so that the dry solid concentration was 0.5%. Japanese white rabbit with shaved back (female, 3 per group, weight around 2.3kg)
Was applied to the skin. At 24, 48 and 72 hours after application, evaluation was performed using erythema and edema as indices based on the criteria of Draize. As a result, no erythema and edema were observed in all animals, and it was judged that there was no problem with regard to primary skin irritation.

(Test 4) Safety Test (2) Skin Cumulative Irritation Test Various plant extracts obtained in Production Examples 1 to 3 were prepared in purified water so as to have a dry solid concentration of 0.5%. Hartley guinea pig with shaved back (female, 3 per group, weight 32)
0.5 g / animal) was applied to the skin (about 0 g) once a day, 5 times a week. Application was performed over two weeks and shaving was performed on the last application day of each week. Evaluation was performed using erythema and edema as indices based on the criteria of Draize on each application day and the day after the last application day. As a result, no erythema or edema was observed in any of the animals for 2 weeks, and it was judged that there was no problem with respect to the cumulative skin irritation.

(Test 5) Safety test (3) Single dose toxicity test Various plant extracts obtained in Production Examples 1 to 3 were adjusted with purified water to a concentration of 12.5%. kg quantity,
Before the test, ddy mice (male and female, 5 animals per group, 5 weeks old) which had been fasted for 4 hours were orally administered, and the appearance and degree of toxic symptoms were observed over time. As a result, no abnormality was observed in all the mice for 14 days, and no abnormalities were found in the dissection results. Therefore, the LD50 was 2,000 mg / kg or more, and it was determined that the substance was safe.

(Prescription examples) Production of melanin production inhibitor, active oxygen scavenger or cosmetic composition According to the above evaluation results, the following formulation examples are shown. And only the compounding amount is shown. Further, the present invention is not limited to these.

(Formulation Example 1) Emulsion weight% 1. Squalane 8.0 2. Jojoba oil 7.0 3. Cetyl alcohol 1.5 4. Glycerin monostearate 2.0 5. Polyoxyethylene (20) cetyl ether 3.0 6. Polyoxyethylene (20 ) Soorbitan monooleate 2.0 7.1,3-butylene glycol 1.0 8. Glycerin 2.0 9. Banaba 70% ethanol extract 5.0 10. Preservative (paraoxybenzoate) qs 11. perfume qs 12. Purified water 100

(Formulation Example 2) Cosmetic oil weight% 1. Liquid paraffin 30.0 2. Squalane 20.0 3. Olive oil 20.0 4. Isopropyl palmitate 10.0 5. Jasmine hot water extract 3.0 6. Aloe vera pressed extract 1.0 7. Valerian fever Water extract 1.0 8. Butyl hydroxyanisole 0.1 9. Preservative (benzalkonium chloride) proper amount 10. Perfume proper amount 11. Purified water 100 residue

(Formulation Example 3) Soft lotion weight% 1. Glycerin 5.0 2.1,3-butylene glycol 5.0 3. Polyoxyethylene sorbitan monolaurate (20E.O) 1.0 4. Ethanol 15.0 5. Puer 50% ethanol extraction Liquid 3.0 6. Banaba 30% ethanol extract 1.0 7. Kumazasa 30% 1,3-butylene glycol extract 1.0 8. Antibacterial and preservative (thiamine lauryl sulfate) qs 9. perfume qs 10. Purified water 100

(Formulation Example 4) Astringent lotion weight% 1. Sorvitol 2.0 2. POE (20) oleyl alcohol 1.0 3. Ethanol 15.0 5. Banaba 50% 1,3-butylene glycol extract 2.0 6. Rubus 50% ethanol Extract 1.0 7. Hamamelis 50% ethanol extract 1.0 8. Allantoin 0.2 9. Astringent (zinc sulfocarbonate) 0.2 10. Antibacterial and preservative (thiamine lauryl sulfate) qs 11. perfume qs 12. Purified water 100 Residue

(Formulation Example 5) Two-layer type lotion (liquid to liquid type)% by weight 1. Squalane 8.0 2. POE sorbitan tetraoleate 0.3 3. Sorbit 1.0 4. Ethanol 15.0 5. Uba 30% propylene glycol extraction Liquid 2.0 6. Kiwi 30% ethanol extract 1.0 7. Ascorbic acid 0.2 8. Astringent (sodium sulfocarbonate) 0.2 9. Preservative (phenoxyethanol) qs 10. Fragrance qs 11. Purified water 100

(Formulation Example 6) Carmine lotion (liquid to solid) wt% 1. Glycerin 3.0 2.1, 3-butylene glycol 5.0 3. Ethanol 15.0 4. Iron oxide (Bengara) 0.2 5. Zinc oxide 0.5 6. Kaolin 2.0 7. Jasmine 50% propylene glycol extract 2.0 8. Placenta extract 1.0 9. Camphor 0.2 10. Phenol 0.03 11. Preservative (photosensitizer 201) qs 12. spices qs 13. purified water 100

(Formulation Example 7) Peel-off pack wt% 1. Glycerin 5.0 2. Propylene glycol 4.0 3. Polyvinyl alcohol 15.0 4. Ethanol 8.0 5. Polyoxyethylene glycol 1.0 6. Pantothenyl ethyl ether 1.0 7. Jasmine essential oil 3.0 8 Banaba 50% ethanol extract 1.0 9. Seaweed 50% ethanol extract 1.0 10. Appropriate amount of flavoring agent 11. Appropriate preservative (paraoxybenzoate) 12. Purified water 100

(Formulation Example 8) Cold cream weight% 1. Salicone beeswax 11.0 2. Liquid paraffin 22.0 3. Lanolin 10.0 4. Olive oil 15.0 5. Borax 0.5 6. Uba 50% 1,3-butylene glycol extract 1.0 7 Puer 50% 1,3-butylene glycol extract 2.0 8. Liquid shea fat 1.0 9. Hawthorn 50% 1,3-butylene glycol extract 2.0 10. Preservative (acrinol) 0.1 11. Appropriate perfume 12. Purified water 100 And the rest

(Formulation Example 9) Face Wash Cream% by Weight 1. Myristic acid 25.0 2. Stearic acid 5.0 3. Tallow fatty acid 5.0 4. Propylene glycol 10.0 5. Potassium hydroxide 6.0 6. Coconut oil fatty acid diethanolamide 6.0 7. Jasmine 50 % 1,3-butylene glycol extract 1.0 8. Shiitake 50% 1,3-butylene glycol extract 2.0 9. Dipotassium glycyrrhetinate 1.0 10. Lactoferrin solution 0.1 11. Preservative (salicylic acid) 0.1 12. Fragrance Appropriate amount 13. Residue with 100 purified water

(Formulation Example 10) Body soap weight% 1. Potassium laurate 15.0 2. Potassium myristate 5.0 3. Propylene glycol 5.0 4. Banaba 70% 1,3-butylene glycol extract 0.5 5. Spicy 30% 1 , 3-butylene glycol extract 0.5 6. Toki 30% 1,3-butylene glycol extract 0.5 7. Tormentilla 30% 1,3-butylene glycol extract 0.5 8. Polyethylene powder 0.5 9. Natto metabolite 0.5 10 Amino acids (glycine, glutamine, etc.) 0.5 11. Preservative (undecylenic acid, phenol) proper amount 12. pH adjuster proper amount 13. Purified water 100 residue

(Formulation Example 11) Sunscreen cosmetics (O / W type)% by weight 1. Oxybenzone 2.0 2. Octyl paramethoxycinnamate 5.0 3. Squalane 10.0 4. Vaseline 5.0 5. Stearyl alcohol 3.0 6. Stearic acid 3.0 7. Glyceryl monostearate 2.0 8. Polyethyl acrylate 1.0 9.1,3-butylene glycol 6.0 10. Disodium edetate 0.1 11. Triethanolamine 99% 1.0 12. Titanium dioxide 5.0 13. Poor 30% 1,3- Butylene glycol extract 0.5 14. Birch 50% ethanol extract 0.5 15. Safflower 50% ethanol extract 0.5 16. Preservative (paraben) qs 17. Purified water 100 residue

(Formulation Example 12) Sunscreen cosmetics (oil type)% by weight 1. Liquid paraffin 70.0 2. Ethyl paraaminobenzoate 1.0 3. Tetrahydroxybenzophenone 1.0 4. Cetyl octanoate 25.0 5. Banaba 30% 1,3 -Butylene glycol extract 0.5 6. Pine 30% 1,3-butylene glycol extract 0.5 7. Timpi 50% ethanol extract 0.5 8. Antioxidant (butylhydroxytoluene)

(Formulation Example 13) Shampoo weight% 1. Triethanolamine lauryl sulfate 5.0 2. Sodium polyoxyethylene lauryl ether sulfate 12.0 3.1,3-butylene glycol 4.0 4. Diethanolamide laurate 2.0 5. Disodium edetate 0.1 6. Banaba 50% propylene glycol extract 2.0 7. Uba 50% propylene glycol extract 2.0 8. Rosemary 30% ethanol extract 1.0 9. Collagen hydrolyzate 1.0 10. Antibacterial and preservative (thiamine lauryl sulfate) 11.Appropriate amount of pH adjuster 12.Appropriate amount of fragrance 13.Remainder to make purified water 100

(Formulation Example 14) Rinse weight% 1. Stearyltrimethylammonium chloride 2.0 2. Cetostearyl alcohol 2.0 3. Polyoxyethylene lanolin ether 3.0 4. Propylene glycol 5.0 5. Poor 50% ethanol extract 1.0 6. Aloe 50 % Ethanol extract 1.0 7. Trehalose solution 1.0 8. Hydrolyzed silk solution 1.0 9. Peony skin 50% ethanol extract 0.5 10. Antibacterial and preservative (benzalkonium chloride) qs 11. perfume qs 12. purified water 100 and the rest

(Formulation Example 15) Hair liquid weight% 1. Ethanol 29.0 2. Polyoxypropylene butyl ether phosphoric acid 10.0 3. Polyoxypropylene monobutyl ether 5.0 4. Triethanolamine 1.0 5. Jasmine hot water extract 1.0 6. Palietalia 50% methanol extract 1.0 7. Tonin 50% methanol extract 1.0 8. Seaweed 50% 1,3-butylene glycol extract 1.0 9. Keratin decomposition solution 1.0 10. Antibacterial and preservative (paraben, benzalkonium chloride) 11.Appropriate amount of fragrance 12.Purified water 100 residue

(Formulation Example 16) Hair tonic weight% 1. Ethanol 40.0 2. Ethyl oleate 1.0 3. Polyoxyethylene (40) hydrogenated castor oil 2.0 4. Banaba 50% 1,3-butylene glycol extract 1.0 5. Sodium hyaluronate solution 1.0 6. Carboxymethyl chitin solution 1.0 7. Whey solution 1.0 8. Mucopolysaccharide solution 1.0 9. Antibacterial and preservative (paraben) 0.1 10. Appropriate perfume 11. Purified water 100

(Formulation Example 17) Granule bath agent weight% 1. Sodium bicarbonate 58.0 2. Anhydrous sodium sulfate 30.0 3. Borax 3.0 4. Pual 70% ethanol extract 4.0 5. Jasmine 50% ethanol extract 2.0 6. 70% Erythrophila Ethanol Extract 1.0 7. Chamomile 70% Ethanol Extract 1.0 8. Orange Juice 1.0

(Formulation Example 18) Coating protective agent
Uva 30% ethanol extract on gauze or liniment cloth
It is impregnated with a prescription solution containing an appropriate amount of antibiotics, anti-inflammatory, etc., and attached to the wound. Alternatively, a Uba 30% ethanol extract may be directly sprayed locally and covered with gauze or the like.

(Test 6) Use effect test The effect when the cosmetic composition of the present invention was actually used was examined. Use test is for those who are worried about spots, freckles, dark and dark, and those who are worried about dry skin, glossy and firm skin 3
The test was carried out by applying an appropriate amount of the emulsion of Formulation Example 1 to the face over three months, twice a day, in the morning and at night, after washing the face twice a day. As a control, a mixture prepared by removing the respective plant extracts of the present invention from the emulsion in the same manner was used. The evaluation was performed according to the following criteria. The results are shown in Tables 1 and 2, and the numbers in the table represent the number of persons. No one complained of abnormal skin during the use period.

"Stain, freckles and skin color improving effect" Effective: The freckles, freckles and skin color were white and reduced. Slightly effective: White spots and freckles and skin color were slightly reduced. Ineffective: No change from before use.

[0114]

"Skin feel improving effect" Efficacy: Dry skin and skin gloss / tension increased, and skin was improved. Slightly effective: Dry skin and skin gloss / tension increased slightly, and skin was improved. Ineffective: No change from before use.

[0116]

(Test Results) As shown in Tables 1 and 2, the emulsion containing the jasmine, banaba, uba, and puer extracts of the present invention significantly improved dry skin, gave gloss and firmness to the skin, and Also, it was confirmed that white spots, freckles and skin color were also reduced.

(Test 10) Use effect test The effect when the skin care cosmetic composition of the present invention was actually used was examined. The use test is for people suffering from eczema and rough skin.
The washing was performed twice a day, in the morning and at night, by applying an appropriate amount of the emulsion of Formulation Example 1 to the face over three months after washing the face. As a control, a mixture prepared by removing the respective plant extracts of the present invention from the emulsion in the same manner was used. The evaluation was performed according to the following criteria. The results are shown in Table 3 and the numerical values in the table represent the number of persons. No one complained of abnormal skin during the use period.

"Beautiful skin effect" Efficacy: Eczema and rough skin were improved. Somewhat effective: Eczema and rough skin were slightly improved. Ineffective: No change from before use.

[0120]

(Test Results) As shown in Table 3, it was confirmed that the emulsion containing the jasmine, banaba, uba, and puer extract of the present invention improved eczema and rough skin.

[0122]

EFFECT OF THE INVENTION The melanin production inhibitor, active oxygen scavenger or cosmetic composition containing jasmine, banana, uba, and puer extract of the present invention has an excellent melanin production inhibitory effect and has a whitening effect whitening effect. The effect was confirmed. In addition, the active oxygen should be significantly eliminated / suppressed, and the skin should also be reduced from spots and freckles. or,
It can improve dry skin, eczema and rough skin, and can also give the skin a shine and firmness, making it safe for humans and animals. The present invention can be used for other general foods and drinks.

[Brief description of the drawings]

BRIEF DESCRIPTION OF DRAWINGS FIG. 1 is a graph showing the inhibition rate of each plant extract of jasmine, banaba, uba, and puer of the present invention on the amount of melanin produced.

FIG. 2 is a diagram showing the active oxygen scavenging effect of each of the plant extracts of jasmine, banaba, uba, and puer according to the present invention.

────────────────────────────────────────────────── ───

[Procedure amendment]

[Submission Date] June 25, 1999 (1999.6.2
5)

[Procedure amendment 1]

[Document name to be amended] Statement

[Correction target item name]

[Correction method] Change

[Correction contents]

(Formulation Example 1) Emulsion weight% 1. Squalane 8.0 2. Jojoba oil 7.0 3. Cetyl alcohol 1.5 4. Glycerin monostearate 2.0 5. Polyoxyethylene (20) cetyl ether 3.0 6. Polyoxyethylene (20 ) Soorbitan monooleate 2.0 7.1,3-butylene glycol 1.0 8. Glycerin 2.0 9. A: Jasmine 50% ethanol extract B: Banaba 50% ethanol extract C: Uba 50% ethanol extract D: Puer 50% ethanol Extract * Any one of A to D 5.0 10. Appropriate amount of fragrance and preservatives 11. Residual water with 100 purified water

──────────────────────────────────────────────────続 き Continued on the front page (51) Int.Cl. ⁷ Identification symbol FI Theme coat ゛ (Reference) A61K 35/78 A61K 35/78 CF term (Reference) 4C083 AA032 AA072 AA082 AA111 AA112 AA122 AB032 AB152 AB212 AB232 AB242 AB312 AB352 AB442 AC012 AC022 AC072 AC092 AC102 AC122 AC132 AC152 AC182 AC242 AC342 AC352 AC422 AC432 AC442 AC472 AC482 AC532 AC542 AC582 AC642 AC682 AC692 AC782 AC862 AC902 AD022 AD042 AD112 AD312 AD322 AD332 AD412 AD452 AD512 AD532 AD642 BB51 CC01 CC03 CC05 CC06 CC39 DD05 DD16 DD21 DD23 DD30 DD31 DD33 EE16 EE17 EE22 4C088 AB12 AB45 AB64 AC03 AC05 AC06 BA09 BA10 CA03 MA63 NA14 ZA89

Claims (3)

[Claims] 1. A melanin production inhibitor comprising at least one plant extract selected from jasmine, banaba, uba, and puer. 2. An active oxygen scavenger comprising at least one plant extract selected from jasmine, banana, uba, and puer. 3. A cosmetic composition comprising at least one of the melanin production inhibitor and the active oxygen scavenger according to claim 1 or 2.