JPH07157420A - Cosmetic - Google Patents

Abstract

PURPOSE:To obtain a cosmetic having effectiveness capable of being provided with improved whitening, antioxidation and hyaluronidase activity inhibiting effect in addition to an advantage in appearance and an improved moist holding property by cholesteric liquid crystals. CONSTITUTION:This cosmetic comprises a cholesteric liquid crystal compounded with >=1 extract of Adhatoda vasica, Lagerstroemia speciosa, Woodfordia fruticosa, Cymbopogon nardus, Cardiospermum halicacabum, Vetiveria zizanoides, Piper longum, Michelia champaca, Hemidesmus indicus, Piper chaba, Tinospora cordifolia, Melaleuca leucadendron, Azadirachdt indica, Murraya koenigii, Sphaeranthus indicus, Phyllanthus nuriri, Desmodium gangeticum and Smilax zeylanica. The liquid crystal or an effective component of the extract can be uniformly coated on a skin by making the liquid crystal to an aerosol and this cosmetic can be discriminated from other ones even in its appearance.

Description

Detailed Description of the Invention

[0001]

FIELD OF THE INVENTION The present invention relates to improvements in cholesteric liquid crystal cosmetic compounding agents. More specifically, in cosmetics using cholesteric liquid crystal, the color development in the skin temperature region is further improved, the skin is not irritated, the water retention ability is improved, and the addition of a herbal medicine causes a whitening effect and an antioxidant effect. The present invention relates to a cosmetic product having added effects such as action and suppression of hyaluronidase activity.

[0002]

2. Description of the Related Art A liquid crystal shows a special state that has a mechanical property of a liquid and an optical property of a crystal, and this phenomenon occurs during the transition from a solid to a liquid.
exhibiting an orophic state). A substance exhibiting this phenomenon was identified by German physicist O. Lehmann was named Liquid Crystal. When simply referring to liquid crystal, this material is meant.

The liquid crystal can be classified into three phases of smectic, nematic and cholesteric according to the molecular arrangement. In the cholesteric liquid crystal, the molecular direction of the molecular layer arranged in a plane in a certain direction changes spirally with the layer,
The molecular arrangement has a helical structure. Cholesteric liquid crystals exhibit a color because they have this helical structure, and when the pitch of the helix and the wavelength of light coincide, strong selective reflection occurs. However, not all cholesteric liquid crystals are colored, and even less are discolored over the entire visible range such as red, yellow, green, blue, and indigo.

Nevertheless, what makes cholesteric liquid crystals more useful is that the color temperature range and temperature sensitivity can be adjusted by mixing several kinds of liquid crystals or adding other substances. Thus, at present, -20 to 250
Liquid crystals with sensitivities every 3 ° C. have been obtained over the temperature range of ° C.

The importance of cholesteric liquid crystals in cosmetics is that, together with the aesthetic appearance due to this coloration phenomenon, when this formulation is applied to the skin, the cholesteryl esters give the skin a moisturizing and softening action and also a natural oil. Because it is useful as a substitute for. This is because cholesterol itself, like its esters, is a natural compound that does not harm the skin.

Most cholesteric liquid crystals are esters of cholesterol or cholesteryl with various fatty acids. As described above, the fact that liquid crystals have various advantages as a cosmetic product is disclosed in JP-A-2-223506 and JP-A-2-223506.
No. 232573, etc.

On the other hand, the plant is Adatoda bashika (A
dhatoda vasa) is a plant belonging to the genus Adatoda of the genus Lepidoptera, distributed in Punjab, Assam, India to Sri Lanka and Singapore, and is an evergreen shrub cultivated in various tropical regions. In India, it is an important medicinal plant that has been used for asthma, fever, jaundice, blood purification, etc. for more than 2000 years.

Lagerstrobin Clover
emia speciosa) is a plant of the genus Cercisaceae, which belongs to the family Liliaceae, and is a semi-deciduous tree growing in India. In India, roots are used for heat and diarrhea, and bark and leaves are used as laxatives.

Woodfodia Fruticosa (Woo
dfordia fruticosa) is a dicotyledonous net, a leaflet sub net, and a larvae of the order Lepidoptera, distributed in sunny areas in the lowlands of Sri Lanka, India. Flowers are used as dysentery, and leaves are used as medicines when a snake bites.

Neem (Azadirachdt)
indica) is a plant of the genus Asteraceae and is distributed in temperate regions of India, Sri Lanka, and Myanmar. This bark is used for fever, vomiting and thirst.

Philanthus Nuriri
hus nuriri) is a dicotyledonous plant net, a leaflet sub net,
It is a plant of the family Euphorbiaceae, widely distributed in the tropics, and in Sri Lanka, it is distributed as a weed in wastelands and cultivated areas. In Sri Lanka, it is used for diarrhea, jaundice and gonorrhea.

Cymbogon n
Ardus) is a monocotyledonous net, a plant of the genus Poaceae, Poaceae, and Ogarkaya, which is used as a raw material for mosquito repellents, fragrances, and soaps, and is used as an anthelmintic, a cold remedy, and an antipyretic agent in South Africa.

Desmodium Gangechikum (Desm
odium gangeticum) is a dicotyledonous net,
Used for amenorrhea and abdominal pain.

Cardiosperm
um halicacabum) is a dicotyledonous plant, a leaflet sub net, a sorghum, a family of sorghum, and a genus of Pleurotus, which is a vine that is native to South Africa but originally a perennial jaundice, gonorrhea, hives, snake. It has been used for bites of people.

Muraya Koenigi Muraya (Murraya)
koenigii) is a dicotyledonous net, a leaflet sub net, a dwarf messenger, a plant of the Rutaceae family, distributed in India and Sri Lanka, and is commonly found in arid lowlands. As a medicinal substance, it has been used for constipation, abdominal colic, diarrhea, etc.

Smilax Zeilanica (Smilax
Zeylanica) is a plant of the monocotyledonous net, liliaceae, genus Shiode, and was used for the treatment of sexually transmitted diseases, dysentery, and rheumatism.

The vetiver (Vetiberia ziza)
(Noides) is a monocotyledonous net, a plant of the family Poaceae, also known as Kasukaskaya, Kusukuskaya and the like. It grows naturally in India and Sri Lanka, and is widely cultivated in tropical Asia for the purpose of collecting aromatic essential oils. It is used as an antipyretic and fragrance.

Indian salsa (Hemidesmus i)
ndicus) is a dicotyledonous net, a joint-veined subweb, and a plant of the family Oleaceae, and is an evergreen woody vine. It is used for antipyretic, skin diseases and gynecological diseases.

Hihatu (Piper longum) is a plant of dicotyledonous net, leaflet sub net, pepper order, pepper family, pepper genus, which is mainly produced in Indonesia, Philippines, Vietnam and northern India. It is used as an aromatic stomachic, analgesic and antidiarrheal drug for headache, toothache, diarrhea, vomiting, etc.

[Chapter pepper]
a) is a plant of dicotyledonous net, leaflet subweb, pepper order, pepper family, pepper genus. It is used for digestive loss, loss of appetite, asthma, cough, etc.

[Tinospora]
cordifolia) is a plant of the family Azaleasaceae, which is a perennial climbing plant, and has been used for diuresis, laxation, malaria and the like.

[Michelia cha]
mpaca) is an evergreen tree of the dicotyledonous net, the isolated leaflet subweb, the Ranunculaceae magnoliaceae, and the genus Scutellariae. It is applied to tonicity, rheumatism and cough.

Kobano Blush tree (Melaleuc)
a leucadendron) is a plant of dicotyledonous net, leaflet sub net, Tenninka, thigh family, cobanobrush, and is an evergreen tree also known as Kayupte, also known as northern Kaypute, New Caledonia, Malaysia and India. . This bark is called the Shirasen layer and is used as a Chinese medicine. Its purpose is to apply to analgesia, nervous breakdown, insomnia, etc.

Sphalanx Index (Spha
eranthus indicus) is a plant of the Asteraceae family that is commonly found in moist areas of lowland paddy fields in India, Sri Lanka, Malaysia, Africa and China, with roots and seeds as anthelmintic agents and bark as a remedy for hemorrhoids. Grass is used as a detoxifier for fish.

[0025]

The object of the present invention is to improve cosmetics using cholesteric liquid crystals by further improving the color development in the skin temperature region and by not irritating the skin and improving the water retention ability. In addition, the present invention relates to a cosmetic product to which the effects of whitening action, antioxidant action, hyaluronidase activity suppression and the like are added by adding a crude drug.

[0026]

[Means for Solving the Problems] In order to solve the above problems, the present inventors have screened and investigated substances that have been used for food for many years and have been confirmed to be safe for the human body. Found the substance.

That is, the present invention relates to a cholesteric liquid crystal and an adatda vashika, hawthorn crape myrtle, wood phodia fruticosa, kousuigaya, fukuenkazura, vetiver, hihatsu, kinkokuboku, indian salsa,
It was solved by including Chaba Pepper, Spodoptera litura, Kobanobushokiki, Neem, Muraya Coenigi Muraya Coenigii, Sphalanthus Indicus, Philanthus Nuriri, Desmodium Gangechicum, Smilax Zeiranica.

As the liquid crystal, cholesteryl oleate, cholesteryl butyrate, cholesteryl laurate, cholesteryl decanoate and cholesteryl nonanoate are mixed with cholesteryl 12-hydroxystearate in two or more kinds of esters selected from the group consisting of cholesteryl linoleate and cholesteryl linoleate. The liquid crystal composition disclosed by the applicant in JP-A-1-246209, such as a liquid crystal composition containing cholesteryl 12-hydroxystearate, and

A liquid crystal composition containing cholesteryl heptanoate and cholesteryl 12-hydroxystearate, or at least one selected from the group consisting of cholesteryl heptanoate, cholesteryl oleate, cholesteryl butyrate, cholesteryl laurate, cholesteryl decanoate and cholesteryl nonanoate. Applicant who compounded is Japanese Patent Application Laid-Open No. 2-2
The liquid crystal composition disclosed in Japanese Patent No. 23506 develops color as a liquid crystal in a human skin temperature region, and thus can be preferably used.

Production Example 1 300 ml of ethanol was added to 10 g of the material of Adatda vashika (dry product) and left for 5 days with occasional stirring. This was filtered and freeze-dried.

Production Example 2 300 ml of a 50% aqueous ethanol solution was added to 10 g of the material of Adatda vashika (dry product), and the mixture was left for 5 days with occasional stirring. This was filtered and freeze-dried.

Production Example 3 10 g of Adatda vashika wood (dried product) and 30 parts of purified water
Add 0 ml and heat for 3 hours. This was allowed to cool, then filtered and freeze-dried.

Production Example 4 300 g of ethanol was added to 10 g of the leaves of the Crape Myrtle Clover, which was left for 5 days with occasional stirring.
This was filtered and freeze-dried.

Production Example 5 To 10 g of Spodoptera litura leaves (dry product) was added 300 ml of a 50% ethanol aqueous solution, and the mixture was left for 5 days with occasional stirring. This was filtered and freeze-dried.

Production Example 6 10 g of the leaves of the Crape Myrtle Crape Myrtle (dry product) were added to purified water 3
Add 00 ml and heat for 3 hours. This was allowed to cool, then filtered and freeze-dried.

Production Example 7 Woodfordia Fruticosa
a. fruticosa) flowers and leaves (dry product) 10
To 300 g of ethanol, 300 ml of ethanol was added, and the mixture was left for 5 days with occasional stirring. This was filtered and freeze-dried.

Production Example 8 Woodfordi Fruticosa
a. fruticosa) flowers and leaves (dry product) 10
300 ml of 50% ethanol aqueous solution was added to g and left for 5 days with occasional stirring. This was filtered and freeze-dried.

Production Example 9 Woodfordia Fruticosa
a. fruticosa) flowers and leaves (dry product) 10
Add 300 ml of purified water to g and heat for 3 hours. This was allowed to cool, then filtered and freeze-dried.

Production Example 10 10 g of rhizome (dry product) of Spodoptera frugiperda was added to ethanol 3
00 ml was added and left for 5 days with occasional stirring. This was filtered and freeze-dried.

Production Example 11 300 g of 50% ethanol was added to 10 g of rhizome (dry product) of Spodoptera litura, and the mixture was left for 5 days with occasional stirring. This was filtered and freeze-dried.

Production Example 12 10 g of rhizome (dry matter) of Spodoptera litura is purified water 300
Add ml and heat for 3 hours. This was allowed to cool, then filtered and freeze-dried.

Production Example 13 300 g of ethanol was added to 10 g of the whole grass (dry product) of D. radix and left for 5 days with occasional stirring. This was filtered and freeze-dried.

Production Example 14 300 g of 50% ethanol aqueous solution was added to 10 g of whole grass (dry product) of Amaranthus chinensis and left for 5 days with occasional stirring. This was filtered and freeze-dried.

Production Example 15 10 g of whole grass (dry product) of Pleurotus cornucopiae was added to purified water 30
Add 0 ml and heat for 3 hours. This was allowed to cool, then filtered and freeze-dried.

Production Example 16 To 10 g of vetiver root (dry product) was added 300 ml of a 50% aqueous ethanol solution, and the mixture was left for 5 days with occasional stirring. This was filtered and freeze-dried.

Production Example 17 300 g of 50% ethanol aqueous solution was added to 10 g of the root of a hihatu (dry product), and the mixture was left for 5 days with occasional stirring.
This was filtered and freeze-dried.

Production Example 18 300 g of a 50% ethanol aqueous solution was added to 10 g of quince flowers (dry product), and the mixture was left for 5 days with occasional stirring. This was filtered and freeze-dried.

Production Example 19 300 g of 50% ethanol aqueous solution was added to 10 g of Indian salsa root (dried product) and left for 5 days with occasional stirring. This was filtered and freeze-dried.

Production Example 20 300 g of a 50% aqueous ethanol solution was added to 10 g of the roots (dry product) of cabbage and the mixture was left for 5 days with occasional stirring. This was filtered and freeze-dried.

Production Example 21 300 ml of ethanol was added to 10 g of branches (dried product) of Pleurotus cornucopiae, and the mixture was left for 5 days with occasional stirring.
This was filtered and freeze-dried.

Production Example 22 300 g of a 50% aqueous ethanol solution was added to 10 g of branches (dried product) of Pleurotus cornucopiae and the mixture was left for 5 days with occasional stirring. This was filtered and freeze-dried.

Production Example 23 10 g of branches (dried product) of Pleurotus cornucopiae were purified water 3
Add 00 ml and heat for 3 hours. This was allowed to cool, then filtered and freeze-dried.

Production Example 24 50 g of bark (dry product) of Kobanobrushokiki
% Aqueous ethanol solution (300 ml) was added and the mixture was left for 5 days with occasional stirring. This was filtered and freeze-dried.

Production Example 25 To 10 g of neem bark (dry product) was added 300 ml of ethanol, and the mixture was left for 5 days with occasional stirring. This was filtered and freeze-dried.

Production Example 26 To 10 g of neem bark (dried product) was added 300 ml of 50% ethanol aqueous solution, and the mixture was left for 5 days with occasional stirring. This was filtered and freeze-dried.

Production Example 27 10 g of neem bark (dry product) was added to purified water 30
Add 0 ml and heat for 3 hours. This was allowed to cool, then filtered and freeze-dried.

Production Example 28 Murara koenigi
To 10 g of the branch (dried product) i), 300 ml of ethanol was added, and the mixture was left for 5 days with occasional stirring. This was filtered and freeze-dried.

Production Example 29 Murara koenigi
10 g of the branch (i) (dried product) was added with 300 ml of 50% ethanol aqueous solution, and left for 5 days with occasional stirring. This was filtered and freeze-dried.

Production Example 30 Murraya koenigi
To 10 g of the stem and branch (dried product) of i), 300 ml of purified water is added and heated for 3 hours. This was allowed to cool, then filtered and freeze-dried.

Production Example 31 Sphaeranthus Index
To 10 g of whole grass (dry product) of Us indicus) was added 300 ml of ethanol, and the mixture was left for 5 days with occasional stirring. This was filtered, evaporated and freeze-dried.

Production Example 32 Sphaeranthus Index
5 g of whole grass (dry product) of us indicus)
300 ml of 0% aqueous ethanol solution was added, and the mixture was left for 5 days with occasional stirring. This was filtered, evaporated and freeze-dried.

Production Example 33 Sphaeranthus Index
To 10 g of the whole grass (dry product) of Us indicus), 300 ml of purified water is added and heated for 3 hours. This was allowed to cool, then filtered and freeze-dried.

Production Example 34 Phyllanthus nuli
10g of whole plant (dried product)
0 ml was added and left for 5 days with occasional stirring. This was filtered and freeze-dried.

Production Example 35 Phyllanthus nuli
To 10 g of the whole plant (dried product) of riri) was added 300 ml of a 50% aqueous ethanol solution, and the mixture was left for 5 days with occasional stirring. This was filtered and freeze-dried.

Production Example 36 Phyllanthus nuli
riri) 10 g of whole grass (dried product) 300 m of purified water
Add 1 and heat for 3 hours. This was allowed to cool, then filtered and freeze-dried.

Production Example 37 Desmodium Desmodium
Ganeticum) whole grass (dry product) was added to 10 g of 300 ml of ethanol, and the mixture was left for 5 days with occasional stirring. This was filtered and freeze-dried.

Production Example 38 Desmodium Desmodium
50 g of whole plant (ganeticum) (dried product)
% Aqueous ethanol solution (300 ml) was added and the mixture was left for 5 days with occasional stirring. This was filtered and freeze-dried.

Production Example 39 Desmodium Desmodium
Gangetticm) whole grass (dry product) is added to 10 g of purified water 300 ml and heated for 3 hours. This was allowed to cool, then filtered and freeze-dried.

Production Example 40 Smilax zeyla
nica) root (dried product) to 10 g ethanol 300
ml was added and left for 5 days with occasional stirring. This was filtered and freeze-dried.

Production Example 41 Smilax zeylana
Nicah) (dried product) was added to 10 g of 300% of 50% ethanol aqueous solution and left for 5 days with occasional stirring. This was filtered and freeze-dried.

[0071]

EXAMPLE An example of an actual usage will be described below, but the present invention is not limited to this example.

Example 1 parts by weight A Cholesteryl 12-hydroxystearate 3.0 Cholesteryl heptanoate 3.0 Cholesteryl oleate 2.0 Cholesteryl butyrate 1.0 B Preparation example 1 1.0 Purified water 81.9 1% Carboxyvinyl polymer Aqueous solution (neutralization) 1.0 1.3 Butylene glycol 7.0 Preservative 0.1

Example 2 A Cholesteryl 12-hydroxystearate 3.0 Cholesteryl oleate 2.0 Cholesteryl butyrate 1.0 Sterilized pearl oyster extract 1.0 B 5.0% aqueous solution of Production Example 1.0 Purified water 85.9 1% aqueous carboxyvinyl polymer solution (neutralization) 1.0 glycerin 5.0 preservative 0.1

Inhibition of tyrosinase activity (Test method) 0.9 ml of McClbaln buffer, 1.66 mM tyrosine (Tyrosin)
e) 1.0 ml of the solution of the above production example (freeze-dried product).
1 wt / v% aqueous solution (If it is difficult to dissolve, add ethanol to dissolve it, then add purified water and evaporate.
After removing ethanol, 1.0 ml (prepared to be 0.1 wt / v%) was placed in a screw vial and heated in a 37 ° C. constant temperature water bath for 5 minutes or more. Tyrosinase solution (manufactured by Sigma, mushroom-derived, 91
0.1 unit (4 units / ml) was added, and the mixture was kept warm in a 37 ° C. constant temperature water bath, and after 10 minutes, the absorbance was measured at 475 nm. As a control, pure water was added instead of the sample solution and the same measurement was performed. The final concentration of the sample in this test is 0.033%
Becomes (Calculation formula) Tyrosinase activity inhibition rate (%) = {B− (AP)} / B × 100 However, A: Absorbance of sample specimen B: Absorbance of control P: Absorbance due to coloring of sample specimen (3-fold dilution)

[0075]

[Table 1]

(Hyaluronidase activity inhibition test) (Test method) 0.4% sodium hyaluronate 0.1M
(PH 6.0) Weigh 6 g of phosphate buffer solution, and
After standing in a constant temperature water bath at ℃ for 5 minutes, 0.1 wt / v% aqueous solution of the above production example (freeze-dried product) (if it is difficult to dissolve, add ethanol and dissolve, then add purified water and evaporate to remove ethanol. After removal, 0.1 wt / v
%) Was added) and stirred
1% of 0.01% hyaluronidase (manufactured by Sigma, beef testicles, type I-S) 0.1M (pH 6.0) phosphate buffer solution was added and immediately stirred, and 6 ml of Ostwald viscosity placed in a constant temperature water bath at 37 ° C. I put it in the total. 1 minute later,
The viscosity was measured after 5 minutes, 10 minutes, 20 minutes, and 40 minutes. As a control, pure water was added instead of the sample solution and the same measurement was performed. The final concentration of the sample in this test is 0.0125
%. The results are shown in Tables 2 to 5 as indexes, with the viscosity after 1 minute being 100.

[0077]

[Table 2]

[0078]

[Table 3]

[0079]

[Table 4]

[0080]

[Table 5]

[0081]

[Table 6]

[0082]

[Table 7]

[0083]

[Table 8]

[0084]

[Table 9]

[0085]

[Table 10]

[0086]

[Table 11]

[0087]

[Table 12]

[0088]

[Table 13]

[0089]

[Table 14]

[0090]

[Table 15]

[0091]

[Table 16]

[0092]

[Table 17]

(Effect of Active Oxygen Suppression Test) There are various methods for measuring the effect of suppressing active oxygen, but the following method was used this time. Add 2.4 ml of the above mixture of reagents and 0.3 ml of the sample, and add xanthine oxynase. (Prepared with liquid) 0.3 ml of the liquid is added and the absorbance (560 nm) is immediately measured. (Measurement is performed in two quantiles to confirm linearity) Calculation formula Inhibition rate = ((A−B) / A) × 100 A: Change in absorbance per minute when the sample is water B: Sample Change in Absorbance Per Minute Several concentration steps were performed to search for a 50% active oxygen production inhibitory concentration. The preparation method of the sample is that the above production example (freeze-dried product) is dissolved in an aqueous solution (if it is difficult to dissolve, ethanol is added and then purified water is added, and then evaporated.
After removing ethanol, the concentration was adjusted to an appropriate concentration).

[0094]

[Table 18]

Antioxidant test The following test solutions were prepared in 50 ml test tubes with screw caps. Specimen 5 mg 2% linoleic acid ethanol solution 10 ml 0.1 M, pH 7.0 phosphate buffer 10 ml Purified water 5 ml This is left to stand in a thermostat bath at 50 ° C in the dark. The following measurements were taken before 3 days, 6 days, and 8 days before putting this in a constant temperature bath. Test solution 0.125ml, 75% ethanol 1
2.125 ml, 30% ammonium thiocyanate 0.
After 125 ml was added and stirred and left for 3 minutes, 0.125 ml of 0.02N ferrous chloride 3.5% HCl aqueous solution was added, stirred and left for 3 minutes, and the absorbance was measured at a wavelength of 500 nm. The cell length was 10 mm, and the control cell had the test solution replaced with water.

[0096]

[Table 19] * Made by Riken Vitamin Co., Ltd.

[0097]

[Table 20]

[0098]

[Table 21]

[0099]

[Table 22]

[0100]

[Table 23]

[0101]

[Table 24]

[0102]

[Table 25]

[0103]

[Table 26]

[0104]

[Table 27]

[0105]

[Table 28]

[0106]

[Table 29]

[0107]

[Table 30]

[0108]

[Table 31]

[0109]

[Table 32]

[0110]

[Table 33]

[0111]

[Table 34]

[0112]

[Table 35]

[0113]

[Table 36]

[0114]

[Table 37]

[0115]

[Table 38]

[0116]

[Table 39]

[0117]

[Effect] In any of the examples, cholesteric liquid crystal and adatoda vashika, hazelnut crape myrtle, wood phodia fruticosa, kousuigaya, fusenkazura, vetiver, hihatsu, kinkokuboku, indo salsa,
Improves appearance superiority and moisturizing properties by blending extracts of Chaba pepper, Ibonas tsujuraji, Kobanobrushoki, neem, Muraya Coenigii, Spharanthas Indexes, Firanthas nuriri, Desmodium ganghechikum, and Sumirax Zeiranika In addition to these, the effects of whitening, antioxidant, and inhibition of hyaluronidase activity can be added, and the effectiveness as a cosmetic product is increased.

Claims (1)

[Claims] Claims: 1. Cholesteric liquid crystal and adatda vashika, hawthorn crape myrtle, woodphodia fruticosa, kousugaiya, fusenkazura, vetiver, hihatsu, kinkouboku, indian salsa, chalab pepper, bonito tsutsuruji, kobanobrushoki, neemflower, muraya. Cosmetics containing one or more extracts of Coenix, Spharanthus indicus, Firanthas nuriri, Desmodium gangechikum, and Sumirax Zeiranika