CN113144112B - Plant compound essential oil for removing mites and acnes as well as preparation method and application thereof - Google Patents
Plant compound essential oil for removing mites and acnes as well as preparation method and application thereof Download PDFInfo
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- CN113144112B CN113144112B CN202110623227.1A CN202110623227A CN113144112B CN 113144112 B CN113144112 B CN 113144112B CN 202110623227 A CN202110623227 A CN 202110623227A CN 113144112 B CN113144112 B CN 113144112B
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- essential oil
- compound essential
- bamboo
- plant compound
- mites
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- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation or decoction
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Abstract
The invention discloses a plant compound essential oil for removing mites and acnes, and a preparation method and application thereof. Has excellent mite killing effect; the product has no irritation to human skin, can be directly used, can also be applied to daily chemical product formula, and can effectively remove mites and acne.
Description
Technical Field
The invention relates to a plant compound essential oil for removing mites and acne, and a preparation method and application thereof.
Background
Acne, commonly known as "whelk" or "comedo", is a chronic inflammatory disease of hair follicle sebaceous glands, which occurs in young people of 15-25 years old, and is called "whelk". It is clinically characterized by the appearance of acne, papules, pustules, etc., often accompanied by seborrhea; acne removal is a process of treating and eliminating acne by applying medical technology or method.
Recent studies have shown that mites are closely related to acne. The mites parasitic on human bodies are generally divided into two types, namely hair follicle mites and sebaceous gland mites, generally, the probability of the mites infecting the head and face skin is high, the excrement of the mites can cause pore blockage to form black heads, and the skin becomes large in pores and even inflamed after a long time, so that a series of pathological changes such as acne, acne rosacea, folliculitis and the like are caused, and the health of human bodies and the beauty of the face are seriously affected. Therefore, in the process of removing acne, the mite removal is particularly important.
In the current commonly used ocular acaricidal agents, tea tree essential oil, nitazoxanol, benzyl benzoate emulsion, permethrin cream, sulfur ointment and the like are externally used; the oral administration medicines comprise metronidazole, ivermectin and the like, but the treatment medicines have various problems, such as strong irritation, easy allergy (such as tea tree essential oil), easy generation of drug resistance (such as ivermectin) of antibiotic medicines and high price, so that the development of a novel mite removing agent has important significance.
Disclosure of Invention
The invention aims to solve the problem of providing an innovative scheme aiming at the defects in the prior art, in particular to a scheme which can effectively remove mites and acne, does not cause allergy and has low cost.
In order to solve the problems, the invention adopts the following scheme: the plant compound essential oil for removing mites and acnes is characterized by being mixed essential oil extracted from the following plant components in parts by mass: 30-60 parts of schizonepeta tenuifolia, 20-40 parts of bamboo, 10-30 parts of celery seeds and 10-30 parts of orange peels.
Further, the plant compound essential oil for removing mites and acnes according to the design scheme is characterized in that the herba schizonepetae is at least one of stems, leaves and flowers of the herba schizonepetae; the bamboo is at least one of green bamboo, tabasheer and bamboo leaves.
Further, the mite and acne removing plant compound essential oil is characterized in that the mass ratio of the nepeta cataria, the bamboos, the celery seeds and the orange peels is 40: 30: 15: 15.
further, the mite and acne removing plant compound essential oil is characterized in that the mass ratio of the nepeta cataria, the bamboos, the celery seeds and the orange peels is 60: 20: 10: 10.
further, the mite and acne removing plant compound essential oil is characterized in that the mass ratio of the nepeta cataria, the bamboos, the celery seeds and the orange peels is 30: 30: 20: 20.
further, the preparation method of the plant compound essential oil for removing mites and removing acnes according to the design scheme is characterized by comprising the following steps of: a. mixing herba schizonepetae, bamboo, celery seeds and orange peels according to a mass ratio, and adding deionized water, wherein the material-liquid ratio is 1: 10-30; b. then placing the mixture into an ultrasonic generator, adjusting the ultrasonic power to 200-300W, adjusting the temperature to 50-70 ℃, and performing ultrasonic oscillation extraction for 60-120 min; c. and then transferring the essential oil to a steam distillation device, continuously heating until the system keeps a slightly boiling state, extracting for 2-4 h, and collecting the distilled volatile oil part to obtain the mite and acne removing plant compound essential oil.
Further, the mite and acne removing plant compound essential oil is applied to preparation of daily chemical products according to the design scheme.
Further, the application of the mite-removing and acne-removing plant compound essential oil in the preparation of daily chemical products according to the design scheme is characterized in that the daily chemical products comprise water aqua, essence, emulsion, cream, gel, powder, facial mask, handmade soap, spray and wash and care products.
The invention has the following technical effects: the preparation method is simple and easy to operate, and the volatile oil part of the raw material is completely extracted. The results of in-vitro mite killing experiments on the plant compound essential oil show that the plant compound essential oil has excellent mite killing effect; and the product has no irritation to human skin, can be directly used, can also be applied to a daily chemical product formula, and can effectively remove mites and acnes.
In the plant compound essential oil extraction raw materials provided by the invention, the Nepeta cataria (Nepeta cataria) is an annual herbaceous plant, also called catnip, also called Chenopodium ambrosioides, is mainly medicinal, can be eaten as vegetables when being young and tender, and is widely distributed in China. Volatile essential oil can be extracted from fresh plants (stems, leaves, flowers and other parts) of the schizonepeta tenuifolia, and the yield is about 1.5 percent; the GC-MS technology is utilized to identify chemical components in the essential oil, more than 60 compounds can be separated and identified, the highest content of the compounds is nepetalactone, the content of the nepetalactone is about 55%, and other main components comprise germacrene, caryophyllene, pinene and the like. The nepeta tenuifolia essential oil has been reported to have a strong insect repelling effect, but other activity reports are not found; early experiments of the team show that the schizonepeta essential oil has excellent in-vitro acaricidal and antibacterial activities.
Bamboo, also known as Bamboo, known as Bambusoideae (bambuseae or bambooo); perennial gramineous bamboo subfamily plants are various in variety, including moso bamboo, dendrocalamus latiflorus, arrowbamboo and the like. The bamboo skin on the outside of the bamboo is green when fresh and is called green, and the side with yellow color in the bamboo cavity is called tabasheer; the parts of the bamboo applied by the invention are the parts of fresh bamboo leaves, bamboo green and bamboo yellow. Bamboo extract, including fresh succus Bambusae, has been reported to be applied in cosmetics because it contains flavonoids, phenolic acids, various amino acids, and aromatic components, but no application of cosmetic for removing mites and pox has been reported.
Celery belongs to an umbelliferae plant, has a academic name of Apium grauensl. Celery seeds, which are mature seeds of celery, have small body forms, are oval, are mostly brown or dark brown, and contain eucalyptol, umbelliferone, apigenin, linolenic acid, volatile oil and various minerals. Celery seeds are considered to have the effects of dispersing qi, reducing swelling, promoting urination, clearing retardation, reducing blood pressure and the like in Chinese traditional medicine.
Orange peel, the fruit peel of Citrus sinensis (L.) Osbeck) of Rutaceae; the orange peel has the effects of regulating qi, eliminating phlegm, invigorating stomach and removing food stagnation, and the peel is rich in volatile essential oil, and the sweet orange essential oil contains limonene as main ingredient, has moisturizing effect on skin, can balance pH value of skin, and has certain effect on skin growth and repair.
The invention utilizes the principle of 'monarch, minister, assistant and guide' of Chinese traditional medicine to carry out composition, wherein the herba schizonepetae is monarch drug and has excellent mite-removing and antibacterial effects, and the bamboo is minister drug and has good anti-inflammatory and antibacterial effects; the celery seeds are adjuvant drugs and have the effects of clearing heat, dissipating qi and eliminating stagnation; the pericarpium Citri Junoris is used as a messenger drug, and has effects of harmonizing the drugs, moisturizing, whitening, resisting allergy, etc., improving skin pH value of acne part, and promoting skin repair. After the 4 plant raw materials with various effects are compounded, the synergistic effect is exerted; the volatile oil obtained by co-distillation has special effects of mite removal, bacteriostasis, heat clearing, anti-inflammation, detumescence and itching relieving and the like; the extraction and separation method is simple and convenient, no organic solvent is used, the process is green and environment-friendly, and the obtained product has high content of effective substances. The physiological activity detection of the plant compound essential oil shows that the plant compound essential oil has remarkable effects of removing mites and acnes.
Drawings
FIG. 1 is a bar chart of mite mortality rate of compound essential oil and single essential oil of plant.
FIG. 2 is a graph showing the acarid lethality of different concentrations of the compound essential oil.
Detailed Description
The present invention will be described in further detail with reference to the accompanying drawings.
Example 1 preparation of Compound essential oil of plants
Mixing herba Schizonepetae, bamboo, semen Apii Graveolentis, and pericarpium Citri Junoris, wherein the mixture accounts for 40g, 30g, 15g, and 15g of herba Schizonepetae, bamboo, semen Apii Graveolentis, and pericarpium Citri Junoris in 100g of the mixture respectively; 2 kg of deionized water was added; then ultrasonic oscillation is carried out, the ultrasonic power is 250W, the temperature is 60 ℃, and the ultrasonic oscillation time is 90 min; after ultrasonic oscillation is finished, transferring all the materials into a steam distillation device, continuously heating to boil, keeping a slightly boiling state for 3 hours for continuous extraction, and after extraction is finished, distilling and collecting the distilled volatile oil part to obtain the plant compound essential oil, wherein the compound essential oil is light yellow in color and clear, and the extraction yield is 1.58%; the physical and chemical properties were measured, and the refractive index (20 ℃ C.) was 1.4622 and the relative density (20 ℃ C.) was 0.893.
Example 2 preparation of Compound essential oil of plants
Mixing herba Schizonepetae, bamboo, semen Apii Graveolentis, and pericarpium Citri Junoris, wherein the mixture accounts for 60g, 20g, 10g, and 10g of 100g of herba Schizonepetae, bamboo, semen Apii Graveolentis, and pericarpium Citri Junoris; 1kg of deionized water was added; then ultrasonic oscillation is carried out, the ultrasonic power is 300W, the temperature is 70 ℃, and the ultrasonic oscillation time is 60 min; after ultrasonic oscillation is finished, all materials are transferred to a steam distillation device, heating is continuously carried out until boiling, a slightly boiling state is kept for 2 hours, continuous extraction is carried out, after extraction is finished, distillation is carried out, and the distilled volatile oil part is collected, namely the plant compound essential oil, the compound essential oil is light yellow in color and clear, the extraction yield of the essential oil is 1.36%, the physicochemical property is measured, the refractive index (20 ℃) is 1.4615, and the relative density (20 ℃) is 0.889.
Example 3 preparation of Compound essential oil of plant
Mixing herba Schizonepetae, bamboo, semen Apii graveolentis, and pericarpium Citri Junoris, wherein the mixture accounts for 30g, 20g, and 20g of 100g of herba Schizonepetae, bamboo, semen Apii graveolentis, and pericarpium Citri Junoris respectively; 3kg of deionized water was added; then ultrasonic oscillating is carried out, wherein the ultrasonic power is 200W, the temperature is 50 ℃, and the ultrasonic oscillating time is 120 min; after ultrasonic oscillation is finished, all materials are transferred to a steam distillation device, heating is continuously carried out until boiling, a slightly boiling state is kept for 4 hours, continuous extraction is carried out, after extraction is finished, distillation is carried out, and the distilled volatile oil part is the plant compound essential oil, the compound essential oil is light yellow in color and clear, the extraction yield of the essential oil is 1.92%, the physicochemical property is measured, the refractive index (20 ℃) is 1.4641, and the relative density (20 ℃) is 0.901.
Comparative examples 1-4 preparation of Single plant essential oils
100g of herba schizonepetae, 100g of bamboo, 100g of celery seed and 100g of orange peel are weighed and numbered as comparative examples 1-4 in sequence. Volatile oils of herba Schizonepetae, bamboo, semen Apii Graveolentis, and pericarpium Citri Junoris corresponding to comparative examples 1-4, which are single plant essential oils, were prepared according to the preparation method described in example 1.
Example 4 in vitro acaricidal test of 5% concentration of Compound essential oil and Single essential oil
1 materials and methods
1.1 Experimental materials
Equipment: a climatic chamber (Sanyo, MLR-350H, Japan), a stereomicroscope (Olympus, SZ2, Japan), a transparent adhesive tape, and the like.
Experimental mites: the method for obtaining the human demodex by adopting a transparent adhesive tape pasting overnight method comprises the following specific steps: the examinee is ordered to clean the face thoroughly before sleeping, and then the transparent adhesive tapes with the length of 6 cm and the width of 1.5 cm are respectively stuck to the forehead, the cheek, the nose, the chin and the like of the examinee. And taking off the film the next day, adhering the film on a glass slide, and performing microscopic examination.
Preparing a sample to be tested: the plant compound essential oil and the single-component essential oil prepared according to the examples 1-3 and the comparative examples 1-4 are counted in total by 7 samples, which are numbered as No. 1-7 samples to be tested in sequence, are subjected to cosolvent dissolution by a small amount of cosolvent (DMSO), and are diluted by deionized water to 5% concentration for later use.
1.2 Experimental methods
1.2.1 experimental groups: the number of the liquid to be detected is 1-7, and meanwhile, a 2% metronidazole solution is used as a positive control group, and liquid paraffin is used as a blank control group. Each group of 10 demodex mites tested. The experiment was repeated 3 times for each concentration of the drug solution and the results averaged.
1.2.2 methods of observation: sucking 200 μ L of the liquid medicine with a micropipette, dropping onto a carrier, spreading the liquid medicine with a push sheet, and sticking the adhesive tape for detecting Demodex mites on the glass slide to ensure that the liquid medicine is fully contacted with the worm body. Then the glass slide is placed in an artificial climate box (the temperature is 30 ℃, the humidity is 75 percent), and the death condition of the demodex is observed under a microscope after 4 hours.
1.2.3 criteria for mortality: continuously observing under 400 times microscope for 1 min, judging the mite with the berm chela or the foot paw immobile as dead initially, and observing continuously after 30 min to confirm that the mite with the acarus still immobile is dead.
Corrected mortality rate/% = (number of living mites in blank control group-number of living mites in treatment group)/number of living mites in blank control group x 100
2 results of
TABLE 1 mite-correcting mortality rate of compound essential oil and single essential oil of plant
| Number of | Corrected mortality (%) + -SE |
| Number 1: compound essential oil (5%) | 90.41±6.04 |
| No. 2: compound essential oil (5%) | 82.33±7.16 |
| No. 3: compound essential oil (5%) | 88.12±5.28 |
| No. 4: herba Schizonepetae essential oil (5%) | 64.61±6.13 |
| No. 5: bamboo essential oil (5%) | 27.19±5.72 |
| No. 6: celery seed essential oil (5%) | 48.56±7.65 |
| No. 7: orange peel essential oil (5%) | 33.12±7.19 |
| Metronidazole group (2%) | 56.73±4.07 |
As can be seen from the results of Table 1 and figure 1, the plant compound essential oil has an obvious killing effect on human demodex at a concentration of 5%, the lethality is 80-90%, and is obviously higher than that of a positive control group, namely 2% metronidazole; the four single-plant essential oils have certain killing effect on human demodex at the concentration of 5%, and the fatality rate is 25-65%; therefore, the plant compound essential oil prepared by the invention has an obvious mite killing effect, and has a better effect than the single-component essential oil prepared in the comparative examples 1-4, which shows that the synergistic effect is exerted among all plant components after the formula is formulated.
Example 5 mite mortality test of Compound plant essential oil at different concentrations
1 materials and methods
1.1 Experimental materials
Equipment: climatic boxes (Sanyo, MLR-350H, Japan), stereomicroscopes (Olympus, SZ2, Japan), scotch tape, and the like.
Experimental mites: the method for obtaining the human demodex by adopting a transparent adhesive tape pasting overnight method comprises the following specific steps: the examinee is advised to thoroughly clean the face before sleeping, and then the transparent tapes with the length of 6 cm and the width of 1.5 cm are respectively stuck to the forehead, the cheek, the nose, the chin and the like of the examinee. And the film is taken off the next day and then adhered to a glass slide for microscopic examination.
Preparing a sample to be tested: the plant compound essential oil prepared according to the embodiment 1 is subjected to cosolvent dissolution by using a small amount of cosolvent (DMSO), and then diluted by deionized water in multiple proportions, wherein the final concentrations are 100%, 50%, 25%, 12.5%, 6.25% and 3.125% in sequence for later use.
1.2 Experimental methods
1.2.1 experimental groups: the plant compound essential oil to be detected is divided into 6 concentration gradient groups, and meanwhile, a 2% metronidazole solution is used as a positive control group, and liquid paraffin is used as a blank control group. Each group of 10 demodex mites tested. The experiment was repeated 3 times for each concentration of the drug solution and the results averaged.
1.2.2 methods of observation: sucking 200 μ L of the liquid medicine with a micropipette, dropping onto a carrier, spreading the liquid medicine with a push sheet, and sticking the adhesive tape for detecting Demodex mites on the glass slide to ensure that the liquid medicine is fully contacted with the worm body. Then the glass slide is placed in an artificial climate box (the temperature is 30 ℃, the humidity is 75 percent), and the death condition of the demodex is observed under a microscope after 4 hours.
1.2.3 criteria for mortality: continuously observing under 400 times microscope for 1 min, determining death of mite with proclarm or immobile leg or paw as initial judgment, and determining death of mite with continuous observation after 30 min.
Corrected mortality rate/% = (number of live mites in control group-number of live mites in treatment group)/number of live mites in control group × 100
2 results
TABLE 2 lethality of plant compound essential oil to mites at different concentrations
| Group of | Corrected mortality (%) + - |
| 100 | 100 |
| 50 | 100 |
| 25% concentration | 97.42±6.28 |
| 12.5% concentration | 92.16±5.59 |
| 6.25% concentration | 85.32±7.12 |
| 3.125% concentration | 52.14±6.45 |
| 2% Metronidazole group | 51.36±4.38 |
As can be seen from the results in table 2 and fig. 2, the plant compound essential oil prepared in example 1 has a significant killing effect on human demodex mites, and the mite killing effect increases with the increase of the concentration. According to the curve, when the concentration of the compound essential oil is 50%, the mite mortality rate is 100%; when the concentration of the compound essential oil is 10%, the mite mortality rate is about 90%; its semi-Lethal Concentration (LC) against mites50Value) less than 3%. Experiments fully prove that the plant compound essential oil has an effect of killing human demodex mites and has extremely obvious effect. When the plant compound essential oil is applied to the formulation of daily chemical products such as cosmetics and the like, more than 3g of plant compound essential oil is recommended to be added in each 100g of preparation.
Example 6 preparation of mite and acne removing essence containing plant compound essential oil as main effective component
The mite and acne removing essence containing the plant compound essential oil for removing mites and acne is prepared, and the formula is shown in table 3.
TABLE 3 formula of essence for removing mites and acnes
| Composition (A) | Content (%) |
| Plant compound essential oil | 3 |
| Hydrogenated castor oil PEG-40 | 4.5 |
| Glycerol | 6 |
| Hamamelis mollis extractive solution | 3 |
| Bletilla striata polysaccharide | 2 |
| 1, 3-butanediol | 5 |
| Hyaluronic acid | 0.1 |
| Essence | 0.05 |
| Phenoxyethanol | 0.3 |
| Deionized water | Balance of |
The preparation process comprises the following steps: adding radix Hamamelis mollis extractive solution, rhizoma Bletillae mucopolysaccharide, and hyaluronic acid into glycerol, uniformly dispersing, adding appropriate amount of deionized water, heating and stirring to 75 deg.C, and keeping the temperature for 20-30 min; then adding 1, 3-butanediol, stirring and dissolving under the condition of heat preservation to a transparent state, and cooling after dissolving uniformly to obtain a water phase part.
Adding plant compound essential oil, essence and hydrogenated castor oil PEG-40 into another container, stirring and dissolving to obtain oil phase part; cooling the water phase part to 40-45 deg.C, adding the oil phase part into the water phase part, stirring, and maintaining the temperature for 20-30 min; and finally, adding the balance of deionized water and phenoxyethanol, uniformly stirring, standing and cooling to obtain the mite and acne removing essence.
The mite and acne removing essence is represented by one embodiment of the plant compound essential oil prepared by the invention in mite and acne removing daily chemical products, and can also be prepared into daily chemical products with mite and acne removing effects, such as water aqua, emulsion, cream, gel, powder, facial mask, manual soap, spray, washing and caring products and the like according to a common formula in the daily chemical industry.
Example 6 evaluation of Effect of the essence for removing mites and removing acne
Evaluation target: 40 young people with acne on their face and 15-25 years of age were selected, 20 male and 20 female.
The evaluation method comprises the following steps: the essence for removing mites and acnes prepared in example 5 is smeared for 3 times every morning, noon and evening by a double-blind method, and 28 days are a treatment course.
Evaluation criteria: the effect is remarkable: acne is faded by more than 70 percent; ② has certain effect: acne is faded by more than 30 percent; ③ invalid: the acne is faded by less than 30 percent.
Evaluation results were as follows: 25 cases of obvious effect, accounting for 62.5 percent; 9 cases of the drug are effective, accounting for 22.5 percent; the number of the ineffective 6 cases is 15 percent. The total effective rate reaches 85 percent; no adverse reactions such as skin allergy, redness and swelling were reported in the cases. The mite and acne removing plant compound essential oil has a good acne removing effect.
The preparation method is simple and easy to operate, and the volatile oil part of the raw material is completely extracted. The results of in-vitro mite killing experiments on the plant compound essential oil show that the plant compound essential oil has excellent mite killing effect; and the product has no irritation to human skin, can be directly used, can also be applied to a daily chemical product formula, and can effectively remove mites and acnes. And the plant component raw materials of the embodiment are simple to obtain and low in cost.
Claims (6)
1. The plant compound essential oil for removing mites and acnes is characterized by being prepared from mixed essential oil obtained by extracting the following plant components in parts by mass: 30-60 parts of schizonepeta tenuifolia, 20-40 parts of bamboo, 10-30 parts of celery seeds and 10-30 parts of orange peels; the herba Schizonepetae is at least one of stem, leaf and flower of herba Schizonepetae; the bamboo is at least one of green bamboo, tabasheer and bamboo leaves; the preparation method of the plant compound essential oil for removing mites and acne comprises the following steps: a. mixing the schizonepeta tenuifolia, the bamboo, the celery seed and the orange peel according to a mass ratio, and adding deionized water, wherein the material-liquid ratio is 1: 10-30; b. then placing the mixture into an ultrasonic generator, adjusting the ultrasonic power to 200-300W, adjusting the temperature to 50-70 ℃, and performing ultrasonic oscillation extraction for 60-120 min; c. and then transferring the mixture to a steam distillation device, continuously heating until the system keeps a slightly boiling state, extracting for 2-4 h, and collecting the distilled volatile oil part, namely the mite and acne removing plant compound essential oil.
2. The plant compound essential oil for removing mites and acnes of claim 1, which is characterized in that the mass ratio of the schizonepeta tenuifolia to the bamboo to the celery seeds to the orange peels is 40: 30: 15: 15.
3. The plant compound essential oil for removing mites and acne according to claim 1, characterized in that the mass ratio of the schizonepeta tenuifolia to the bamboo to the celery seed to the orange peel is 60: 20: 10: 10.
4. the plant compound essential oil for removing mites and acne according to claim 1, characterized in that the mass ratio of the schizonepeta tenuifolia to the bamboo to the celery seeds to the orange peels is 30: 30: 20: 20.
5. application of the plant compound essential oil for removing mites and acnes as defined in claim 1 in preparation of daily chemical products.
6. The application of the mite and acne removing plant compound essential oil in preparing daily chemical products according to claim 5, wherein the daily chemical products comprise water aqua, essence, emulsion, cream, gel, powder, facial mask and handmade soap.
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| CN111388358A (en) * | 2020-05-13 | 2020-07-10 | 黄敏 | Plant essential oil composition with mite-killing and acne-removing effects, and preparation and application thereof |
| CN111956583A (en) * | 2020-10-12 | 2020-11-20 | 中华全国供销合作总社南京野生植物综合利用研究所 | Plant combined extract for removing mites and acnes as well as preparation method and application thereof |
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| CN111388358A (en) * | 2020-05-13 | 2020-07-10 | 黄敏 | Plant essential oil composition with mite-killing and acne-removing effects, and preparation and application thereof |
| CN111956583A (en) * | 2020-10-12 | 2020-11-20 | 中华全国供销合作总社南京野生植物综合利用研究所 | Plant combined extract for removing mites and acnes as well as preparation method and application thereof |
Non-Patent Citations (1)
| Title |
|---|
| 植物提取物在化妆品中的应用及展望;杨嘉萌;《日用化学工业》;20130814;第43卷(第04期);第313-316页 * |
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